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2011 MeSH

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Drug Tolerance
MeSH HeadingDrug Tolerance
Tree NumberG07.690.812.260
Tree NumberG07.700.680.260
Annotationdifferentiate from DRUG RESISTANCE; not for tolerability ( = drug / adv eff): Manual 28.19
Scope NoteProgressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
Allowable QualifiersEH GE IM PH RE
Date of Entry19990101
Unique IDD004361


MeSH Tree Structures

 
Physiological Phenomena [G07]
   Pharmacological Phenomena [G07.690]
      Pharmacological Processes [G07.690.812]
Biotransformation [G07.690.812.097]  +
Cytoprotection [G07.690.812.195]
Depression, Chemical [G07.690.812.210]
Down-Regulation [G07.690.812.230]
Drug Interactions [G07.690.812.240]  +
Drug Tolerance [G07.690.812.260]
Tachyphylaxis [G07.690.812.260.910]
Stimulation, Chemical [G07.690.812.850]
Up-Regulation [G07.690.812.925]

 
Physiological Phenomena [G07]
   Physiological Processes [G07.700]
      Pharmacological Processes [G07.700.680]
Biotransformation [G07.700.680.097]  +
Cytoprotection [G07.700.680.195]
Depression, Chemical [G07.700.680.210]
Down-Regulation [G07.700.680.230]
Drug Interactions [G07.700.680.240]  +
Drug Tolerance [G07.700.680.260]
Tachyphylaxis [G07.700.680.260.910]
Stimulation, Chemical [G07.700.680.850]
Up-Regulation [G07.700.680.925]

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