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I-kappa B Kinase
MeSH HeadingI-kappa B Kinase
Tree NumberD08.811.913.696.620.682.700.494
Tree NumberD12.644.360.376
Tree NumberD12.776.476.378
Scope NoteA protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
Entry TermCHUK Kinase
Entry TermConserved Helix-Loop-Helix Ubiquitous Kinase
Entry TermI Kappa B alpha-Associated Protein Kinase
Entry TermI kappa B Kinase
Entry TermIkappaB Kinase
Entry TermIkappaB Kinase alpha
Entry TermIkappaB Kinase beta
Entry TermIkappaB Kinase epsilon
Entry TermIkappaB Kinase gamma
Entry TermIkappaBalpha Kinase
Entry TermIKBKB
Entry TermIKK 1 Kinase
Entry TermIKK 2 Kinase
Entry TermIKK alpha
Entry TermIKK beta
Entry TermIKK epsilon
Entry TermIKK gamma
Entry TermIKKepsilon
Entry TermNF-kappaB Essential Modifier
Entry TermNK-kappa B-Activating Kinase NAK
See AlsoI-kappa B Proteins
Allowable QualifiersAD AE AI AN BI BL CF CH CL CS CT DE DF DU EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UL UR
Registry NumberEC 2.7.11.10
Related NumberEC 2.7.11.10
History Note2006(1997)
Date of Entry20050630
Unique IDD051550


MeSH Tree Structures

 
Enzymes and Coenzymes [D08]
   Enzymes [D08.811]
      Transferases [D08.811.913]
         Phosphotransferases [D08.811.913.696]
            Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
               Protein Kinases [D08.811.913.696.620.682]
                  Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Activin Receptors [D08.811.913.696.620.682.700.062]  +
AMP-Activated Protein Kinases [D08.811.913.696.620.682.700.085]
Bone Morphogenetic Protein Receptors [D08.811.913.696.620.682.700.109]  +
Calcium-Calmodulin-Dependent Protein Kinases [D08.811.913.696.620.682.700.125]  +
Casein Kinases [D08.811.913.696.620.682.700.140]  +
Cyclic Nucleotide-Regulated Protein Kinases [D08.811.913.696.620.682.700.150]  +
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.200]  +
DNA-Activated Protein Kinase [D08.811.913.696.620.682.700.250]
eIF-2 Kinase [D08.811.913.696.620.682.700.300]
G-Protein-Coupled Receptor Kinases [D08.811.913.696.620.682.700.364]  +
Glycogen Synthase Kinases [D08.811.913.696.620.682.700.429]  +
I-kappa B Kinase [D08.811.913.696.620.682.700.494]
Interleukin-1 Receptor-Associated Kinases [D08.811.913.696.620.682.700.526]
Lim Kinases [D08.811.913.696.620.682.700.542]
MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]  +
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]  +
Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]  +
Oncogene Protein v-akt [D08.811.913.696.620.682.700.586]
p21-Activated Kinases [D08.811.913.696.620.682.700.596]
Phytochrome A [D08.811.913.696.620.682.700.606]
Positive Transcriptional Elongation Factor B [D08.811.913.696.620.682.700.626]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]  +
Protein Kinase C [D08.811.913.696.620.682.700.725]  +
Proto-Oncogene Proteins c-akt [D08.811.913.696.620.682.700.755]
Proto-Oncogene Proteins c-bcr [D08.811.913.696.620.682.700.759]
Proto-Oncogene Proteins c-pim-1 [D08.811.913.696.620.682.700.776]
Receptor-Interacting Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700.801]  +
rho-Associated Kinases [D08.811.913.696.620.682.700.814]
Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]  +
TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931]
Vacuolar Sorting Protein VPS15 [D08.811.913.696.620.682.700.965]

 
Amino Acids, Peptides, and Proteins [D12]
   Peptides [D12.644]
      Intracellular Signaling Peptides and Proteins [D12.644.360]
3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]  +
3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]  +
Activating Transcription Factor 6 [D12.644.360.011]
Adaptor Proteins, Signal Transducing [D12.644.360.024]  +
Adenylate Cyclase [D12.644.360.050]
AMP-Activated Protein Kinases [D12.644.360.062]
Apoptosis Regulatory Proteins [D12.644.360.075]  +
Calcineurin [D12.644.360.087]
Calcium-Calmodulin-Dependent Protein Kinases [D12.644.360.100]  +
Casein Kinases [D12.644.360.150]  +
Cold Shock Proteins and Peptides [D12.644.360.175]
Cyclic Nucleotide-Regulated Protein Kinases [D12.644.360.200]  +
Cyclin-Dependent Kinase Inhibitor Proteins [D12.644.360.225]  +
Cyclin-Dependent Kinases [D12.644.360.250]  +
Cyclins [D12.644.360.262]  +
Dual-Specificity Phosphatases [D12.644.360.268]  +
eIF-2 Kinase [D12.644.360.275]
Focal Adhesion Protein-Tyrosine Kinases [D12.644.360.287]
G-Protein-Coupled Receptor Kinases [D12.644.360.293]  +
Glycogen Synthase Kinases [D12.644.360.300]  +
GTP-Binding Protein Regulators [D12.644.360.325]  +
Guanylate Cyclase [D12.644.360.350]
Heterotrimeric GTP-Binding Proteins [D12.644.360.375]  +
I-kappa B Kinase [D12.644.360.376]
I-kappa B Proteins [D12.644.360.378]
Interleukin-1 Receptor-Associated Kinases [D12.644.360.379]
Intracellular Calcium-Sensing Proteins [D12.644.360.381]  +
Lim Kinases [D12.644.360.390]
MAP Kinase Kinase Kinases [D12.644.360.400]  +
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]  +
Mitogen-Activated Protein Kinase Phosphatases [D12.644.360.445]  +
Mitogen-Activated Protein Kinases [D12.644.360.450]  +
Monomeric GTP-Binding Proteins [D12.644.360.525]  +
Mucin-4 [D12.644.360.534]
Olfactory Marker Protein [D12.644.360.543]
p21-Activated Kinases [D12.644.360.552]
Phosphatidylethanolamine Binding Protein [D12.644.360.562]
Phosphoinositide Phospholipase C [D12.644.360.571]  +
Phospholipase C gamma [D12.644.360.581]
Protein Phosphatase 2 [D12.644.360.583]
Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]  +
Receptor-Like Protein Tyrosine Phosphatases [D12.644.360.587]  +
rho-Associated Kinases [D12.644.360.590]
Ribosomal Protein S6 Kinases [D12.644.360.600]  +
SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.644.360.800]  +

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Intracellular Signaling Peptides and Proteins [D12.776.476]
3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]  +
3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]  +
Activating Transcription Factor 6 [D12.776.476.011]
Adaptor Proteins, Signal Transducing [D12.776.476.024]  +
Adenylate Cyclase [D12.776.476.050]
AMP-Activated Protein Kinases [D12.776.476.062]
Apoptosis Regulatory Proteins [D12.776.476.075]  +
Calcineurin [D12.776.476.087]
Calcium-Calmodulin-Dependent Protein Kinases [D12.776.476.100]  +
Casein Kinases [D12.776.476.150]  +
Class I Phosphatidylinositol 3-Kinases [D12.776.476.162]  +
Class II Phosphatidylinositol 3-Kinases [D12.776.476.168]
Class III Phosphatidylinositol 3-Kinases [D12.776.476.171]  +
Cold Shock Proteins and Peptides [D12.776.476.175]
Cyclic Nucleotide-Regulated Protein Kinases [D12.776.476.200]  +
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]  +
Cyclin-Dependent Kinases [D12.776.476.250]  +
Cyclins [D12.776.476.262]  +
Dual-Specificity Phosphatases [D12.776.476.268]  +
eIF-2 Kinase [D12.776.476.275]
Focal Adhesion Protein-Tyrosine Kinases [D12.776.476.287]
G-Protein-Coupled Receptor Kinases [D12.776.476.293]  +
Glycogen Synthase Kinases [D12.776.476.300]  +
GTP-Binding Protein Regulators [D12.776.476.325]  +
Guanylate Cyclase [D12.776.476.350]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]  +
I-kappa B Kinase [D12.776.476.378]
I-kappa B Proteins [D12.776.476.381]
Interleukin-1 Receptor-Associated Kinases [D12.776.476.384]
Intracellular Calcium-Sensing Proteins [D12.776.476.387]  +
Janus Kinases [D12.776.476.393]  +
Lim Kinases [D12.776.476.396]
MAP Kinase Kinase Kinases [D12.776.476.400]  +
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]  +
Mitogen-Activated Protein Kinase Phosphatases [D12.776.476.445]  +
Mitogen-Activated Protein Kinases [D12.776.476.450]  +
Monomeric GTP-Binding Proteins [D12.776.476.525]  +
Mucin-4 [D12.776.476.534]
Olfactory Marker Protein [D12.776.476.543]
p21-Activated Kinases [D12.776.476.548]
Phosphatidylethanolamine Binding Protein [D12.776.476.555]
Phosphoinositide Phospholipase C [D12.776.476.556]  +
Phospholipase C gamma [D12.776.476.558]
Protein Phosphatase 2 [D12.776.476.561]
Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]  +
Proto-Oncogene Proteins c-akt [D12.776.476.565]
Proto-Oncogene Proteins c-fyn [D12.776.476.571]
PTEN Phosphohydrolase [D12.776.476.590]
Receptor-Like Protein Tyrosine Phosphatases [D12.776.476.592]  +
rho-Associated Kinases [D12.776.476.595]
Ribosomal Protein S6 Kinases [D12.776.476.600]  +
SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]  +
Sirtuins [D12.776.476.900]  +
TOR Serine-Threonine Kinases [D12.776.476.925]
ZAP-70 Protein-Tyrosine Kinase [D12.776.476.950]

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