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Mucopolysaccharidosis II
MeSH HeadingMucopolysaccharidosis II
Tree NumberC10.597.606.643.455.750
Tree NumberC16.320.322.500.750
Tree NumberC16.320.400.525.750
Tree NumberC16.320.565.202.715.645
Tree NumberC16.320.565.595.600.645
Tree NumberC17.300.550.575.645
Tree NumberC18.452.648.202.715.645
Tree NumberC18.452.648.595.600.645
AnnotationDF: MPS II
Scope NoteSystemic lysosomal storage disease marked by progressive physical deterioration and caused by a deficiency of L-sulfoiduronate sulfatase. This disease differs from MUCOPOLYSACCHARIDOSIS I by slower progression, lack of corneal clouding, and X-linked rather than autosomal recessive inheritance. The mild form produces near-normal intelligence and life span. The severe form usually causes death by age 15.
Entry TermGargoylism, Hunter Syndrome
Entry TermHunter Syndrome Gargoylism
Entry TermHunter's Syndrome
Entry TermIduronate 2-Sulfatase Deficiency
Entry TermIduronate Sulfatase Deficiency
Entry TermMucopolysaccharidosis 2
Entry TermMucopolysaccharidosis Type 2
Entry TermSulfoiduronate Sulfatase Deficiency
See AlsoIduronate Sulfatase
See AlsoMucopolysaccharidosis I
Allowable QualifiersBL CF CI CL CO DH DI DT EC EH EM EN EP ET GE HI IM ME MI MO NU PA PC PP PS PX RA RH RI RT SU TH UR US VE VI
Entry VersionMPS II
Previous Indexing Mucopolysaccharidosis I (1966-1991)
History Note1992; for MUCOPOLYSACCHARIDOSIS 2 and HUNTER'S SYNDROME use LIPOCHONDRODYSTROPHY 1976-1991
Date of Entry19910621
Unique IDD016532


MeSH Tree Structures

 
Nervous System Diseases [C10]
   Neurologic Manifestations [C10.597]
      Neurobehavioral Manifestations [C10.597.606]
         Intellectual Disability [C10.597.606.643]
            Mental Retardation, X-Linked [C10.597.606.643.455]
Adrenoleukodystrophy [C10.597.606.643.455.124]
Coffin-Lowry Syndrome [C10.597.606.643.455.249]
Fragile X Syndrome [C10.597.606.643.455.500]
Glycogen Storage Disease Type IIb [C10.597.606.643.455.562]
Lesch-Nyhan Syndrome [C10.597.606.643.455.625]
Menkes Kinky Hair Syndrome [C10.597.606.643.455.687]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C10.597.606.643.455.750]
Pyruvate Dehydrogenase Complex Deficiency Disease [C10.597.606.643.455.875]
Rett Syndrome [C10.597.606.643.455.937]

 
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
   Genetic Diseases, Inborn [C16.320]
      Genetic Diseases, X-Linked [C16.320.322]
         Mental Retardation, X-Linked [C16.320.322.500]
Adrenoleukodystrophy [C16.320.322.500.124]
Classical Lissencephalies and Subcortical Band Heterotopias [C16.320.322.500.186]
Coffin-Lowry Syndrome [C16.320.322.500.249]
Fragile X Syndrome [C16.320.322.500.500]
Lesch-Nyhan Syndrome [C16.320.322.500.625]
Menkes Kinky Hair Syndrome [C16.320.322.500.687]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C16.320.322.500.750]
Pyruvate Dehydrogenase Complex Deficiency Disease [C16.320.322.500.875]
Rett Syndrome [C16.320.322.500.937]

 
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
   Genetic Diseases, Inborn [C16.320]
      Heredodegenerative Disorders, Nervous System [C16.320.400]
         Mental Retardation, X-Linked [C16.320.400.525]
Adrenoleukodystrophy [C16.320.400.525.124]
Coffin-Lowry Syndrome [C16.320.400.525.249]
Fragile X Syndrome [C16.320.400.525.500]
Lesch-Nyhan Syndrome [C16.320.400.525.625]
Menkes Kinky Hair Syndrome [C16.320.400.525.687]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C16.320.400.525.750]
Pyruvate Dehydrogenase Complex Deficiency Disease [C16.320.400.525.875]
Rett Syndrome [C16.320.400.525.937]

 
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
   Genetic Diseases, Inborn [C16.320]
      Metabolism, Inborn Errors [C16.320.565]
         Carbohydrate Metabolism, Inborn Errors [C16.320.565.202]
            Mucopolysaccharidoses [C16.320.565.202.715]
Mucopolysaccharidosis I [C16.320.565.202.715.640]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C16.320.565.202.715.645]
Mucopolysaccharidosis III [C16.320.565.202.715.650]
Mucopolysaccharidosis IV [C16.320.565.202.715.655]
Mucopolysaccharidosis VI [C16.320.565.202.715.670]
Mucopolysaccharidosis VII [C16.320.565.202.715.675]

 
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
   Genetic Diseases, Inborn [C16.320]
      Metabolism, Inborn Errors [C16.320.565]
         Lysosomal Storage Diseases [C16.320.565.595]
            Mucopolysaccharidoses [C16.320.565.595.600]
Mucopolysaccharidosis I [C16.320.565.595.600.640]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C16.320.565.595.600.645]
Mucopolysaccharidosis III [C16.320.565.595.600.650]
Mucopolysaccharidosis IV [C16.320.565.595.600.655]
Mucopolysaccharidosis VI [C16.320.565.595.600.670]
Mucopolysaccharidosis VII [C16.320.565.595.600.675]

 
Skin and Connective Tissue Diseases [C17]
   Connective Tissue Diseases [C17.300]
      Mucinoses [C17.300.550]
         Mucopolysaccharidoses [C17.300.550.575]
Mucopolysaccharidosis I [C17.300.550.575.640]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C17.300.550.575.645]
Mucopolysaccharidosis III [C17.300.550.575.650]
Mucopolysaccharidosis IV [C17.300.550.575.655]
Mucopolysaccharidosis VI [C17.300.550.575.670]
Mucopolysaccharidosis VII [C17.300.550.575.675]

 
Nutritional and Metabolic Diseases [C18]
   Metabolic Diseases [C18.452]
      Metabolism, Inborn Errors [C18.452.648]
         Carbohydrate Metabolism, Inborn Errors [C18.452.648.202]
            Mucopolysaccharidoses [C18.452.648.202.715]
Mucopolysaccharidosis I [C18.452.648.202.715.640]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C18.452.648.202.715.645]
Mucopolysaccharidosis III [C18.452.648.202.715.650]
Mucopolysaccharidosis IV [C18.452.648.202.715.655]
Mucopolysaccharidosis VI [C18.452.648.202.715.670]
Mucopolysaccharidosis VII [C18.452.648.202.715.675]

 
Nutritional and Metabolic Diseases [C18]
   Metabolic Diseases [C18.452]
      Metabolism, Inborn Errors [C18.452.648]
         Lysosomal Storage Diseases [C18.452.648.595]
            Mucopolysaccharidoses [C18.452.648.595.600]
Mucopolysaccharidosis I [C18.452.648.595.600.640]
Arrow pointing to current tree nodeMucopolysaccharidosis II [C18.452.648.595.600.645]
Mucopolysaccharidosis III [C18.452.648.595.600.650]
Mucopolysaccharidosis IV [C18.452.648.595.600.655]
Mucopolysaccharidosis VI [C18.452.648.595.600.670]
Mucopolysaccharidosis VII [C18.452.648.595.600.675]

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