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2012 MeSH

MeSH Descriptor Data

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Pentostatin
MeSH HeadingPentostatin
Tree NumberD03.383.742.680.350.200.700
Tree NumberD13.570.230.677
Tree NumberD13.570.685.350.200.700
Scope NoteA potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Entry Term2'-Deoxycoformycin
Entry TermCI-825
Entry TermCo-Vidarabine
Entry TermDeoxycoformycin
Entry TermLederle Brand of Pentostatin
Entry TermNipent
Entry TermNSC-218321
Entry TermPrasfarma Brand of Pentostatin
Entry TermSupergen Brand of Pentostatin
Entry TermWarner-Lambert Brand of Pentostatin
Entry TermWyeth Brand of Pentostatin
Allowable QualifiersAA AD AE AG AI AN BI BL CF CH CL CS CT DU EC HI IM IP ME PD PK PO RE SD ST TO TU UR
Pharm. ActionAdenosine Deaminase Inhibitors
Pharm. ActionAntineoplastic Agents
CAS Type 1 NameImidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
Registry Number53910-25-1
Previous Indexing Azepines (1966-1978)
Previous Indexing Coformycin/analogs & derivatives (1979-1989)
Previous Indexing Deoxyribonucleosides (1971-1978)
History Note90; for CO-VIDARABINE use PENTOSTATIN 1982-97
Date of Entry19890525
Unique IDD015649


MeSH Tree Structures

 
Heterocyclic Compounds [D03]
   Heterocyclic Compounds, 1-Ring [D03.383]
      Pyrimidines [D03.383.742]
         Pyrimidine Nucleosides [D03.383.742.680]
            Formycins [D03.383.742.680.350]
               Coformycin [D03.383.742.680.350.200]
Arrow pointing to current tree nodePentostatin [D03.383.742.680.350.200.700]

 
Nucleic Acids, Nucleotides, and Nucleosides [D13]
   Nucleosides [D13.570]
      Deoxyribonucleosides [D13.570.230]
Deoxyadenosines [D13.570.230.229]  +
Deoxycytidine [D13.570.230.329]  +
Deoxyguanosine [D13.570.230.360]
Deoxyuridine [D13.570.230.430]  +
Dideoxynucleosides [D13.570.230.500]  +
Arrow pointing to current tree nodePentostatin [D13.570.230.677]
Thymidine [D13.570.230.855]  +

 
Nucleic Acids, Nucleotides, and Nucleosides [D13]
   Nucleosides [D13.570]
      Pyrimidine Nucleosides [D13.570.685]
         Formycins [D13.570.685.350]
            Coformycin [D13.570.685.350.200]
Arrow pointing to current tree nodePentostatin [D13.570.685.350.200.700]

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