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Integrin alpha4beta1
MeSH HeadingIntegrin alpha4beta1
Tree NumberD12.776.395.550.200.625.347
Tree NumberD12.776.543.550.200.625.347
Tree NumberD12.776.543.750.705.408.530.500
Tree NumberD12.776.543.750.705.408.850.299
Tree NumberD12.776.543.750.705.877.347
Tree NumberD23.050.301.264.035.850.347
Tree NumberD23.050.301.350.625.347
Tree NumberD23.101.100.110.850.347
Scope NoteIntegrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Entry Termalpha4beta1 Integrin
Entry TermCD49d-CD29
Entry TermIntegrin alpha(4)beta(1)
Entry TermIntegrin Heterodimer alpha4beta1
Entry TermVery Late Activation Antigen-4
Entry TermVery Late Antigen-4
Entry TermVLA-4
Allowable QualifiersAD AG AI AN BI BL CH CL DE DF GE HI IM IP ME PH RE TU UL
Registry Number0
Previous Indexing Integrins (1991-2002)
Previous Indexing Receptors, Lymphocyte Homing (1991-2002)
History Note2003; use INTEGRIN ALPHA4BETA1 (NM) 1991-2002
Date of Entry20020702
Unique IDD039041


MeSH Tree Structures

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Glycoproteins [D12.776.395]
         Membrane Glycoproteins [D12.776.395.550]
            Cell Adhesion Molecules [D12.776.395.550.200]
               Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
Antigens, CD44 [D12.776.395.550.200.625.144]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D12.776.395.550.200.625.347]
Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
L-Selectin [D12.776.395.550.200.625.903]

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Membrane Proteins [D12.776.543]
         Membrane Glycoproteins [D12.776.543.550]
            Cell Adhesion Molecules [D12.776.543.550.200]
               Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
Antigens, CD44 [D12.776.543.550.200.625.144]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D12.776.543.550.200.625.347]
Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
L-Selectin [D12.776.543.550.200.625.903]

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Membrane Proteins [D12.776.543]
         Receptors, Cell Surface [D12.776.543.750]
            Receptors, Immunologic [D12.776.543.750.705]
               Integrins [D12.776.543.750.705.408]
                  Receptors, Fibronectin [D12.776.543.750.705.408.530]
Integrin alpha2beta1 [D12.776.543.750.705.408.530.249]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D12.776.543.750.705.408.530.500]
Integrin alpha5beta1 [D12.776.543.750.705.408.530.750]

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Membrane Proteins [D12.776.543]
         Receptors, Cell Surface [D12.776.543.750]
            Receptors, Immunologic [D12.776.543.750.705]
               Integrins [D12.776.543.750.705.408]
                  Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
Integrin alpha1beta1 [D12.776.543.750.705.408.850.099]
Integrin alpha2beta1 [D12.776.543.750.705.408.850.199]
Integrin alpha3beta1 [D12.776.543.750.705.408.850.249]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D12.776.543.750.705.408.850.299]
Integrin alpha5beta1 [D12.776.543.750.705.408.850.349]
Integrin alpha6beta1 [D12.776.543.750.705.408.850.674]

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Membrane Proteins [D12.776.543]
         Receptors, Cell Surface [D12.776.543.750]
            Receptors, Immunologic [D12.776.543.750.705]
               Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
Antigens, CD44 [D12.776.543.750.705.877.144]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D12.776.543.750.705.877.347]
Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
L-Selectin [D12.776.543.750.705.877.903]

 
Biological Factors [D23]
   Antigens [D23.050]
      Antigens, Surface [D23.050.301]
         Antigens, Differentiation [D23.050.301.264]
            Antigens, CD [D23.050.301.264.035]
               Receptors, Lymphocyte Homing [D23.050.301.264.035.850]
Antigens, CD44 [D23.050.301.264.035.850.144]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D23.050.301.264.035.850.347]
Lymphocyte Function-Associated Antigen-1 [D23.050.301.264.035.850.550]
L-Selectin [D23.050.301.264.035.850.903]

 
Biological Factors [D23]
   Antigens [D23.050]
      Antigens, Surface [D23.050.301]
         Cell Adhesion Molecules [D23.050.301.350]
            Receptors, Lymphocyte Homing [D23.050.301.350.625]
Antigens, CD44 [D23.050.301.350.625.144]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D23.050.301.350.625.347]
Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
L-Selectin [D23.050.301.350.625.903]

 
Biological Factors [D23]
   Biological Markers [D23.101]
      Antigens, Differentiation [D23.101.100]
         Antigens, CD [D23.101.100.110]
            Receptors, Lymphocyte Homing [D23.101.100.110.850]
Antigens, CD44 [D23.101.100.110.850.144]
Arrow pointing to current tree nodeIntegrin alpha4beta1 [D23.101.100.110.850.347]
Lymphocyte Function-Associated Antigen-1 [D23.101.100.110.850.550]
L-Selectin [D23.101.100.110.850.903]

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