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2014 MeSH

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C-Peptide
MeSH HeadingC-Peptide
Tree NumberD06.472.699.587.200.500.250
Tree NumberD12.644.548.586.200.500.250
Annotationfrom proinsulin only: not for peptide fragments from other proteins ( = PEPTIDE FRAGMENTS)
Scope NoteThe middle segment of proinsulin that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of proinsulin, equimolar INSULIN and C-peptide are released. C-peptide immunoassay has been used to assess pancreatic beta cell function in diabetic patients with circulating insulin antibodies or exogenous insulin. Half-life of C-peptide is 30 min, almost 8 times that of insulin.
Entry TermC-Peptide, Proinsulin
Entry TermConnecting Peptide
Entry TermProinsulin C-Peptide
Allowable QualifiersAD AE AG AI AN BI BL CF CH CL CS CT DE DF DU EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UL UR
Registry Number0
Previous Indexing Peptides (1973-1976)
Previous Indexing Proinsulin (1975-1976)
History Note84(77); was see under PEPTIDES 1977-83
Date of Entry19760416
Unique IDD002096


MeSH Tree Structures

 
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
   Hormones [D06.472]
      Peptide Hormones [D06.472.699]
         Pancreatic Hormones [D06.472.699.587]
            Insulins [D06.472.699.587.200]
               Proinsulin [D06.472.699.587.200.500]
Arrow pointing to current tree nodeC-Peptide [D06.472.699.587.200.500.250]
Insulin [D06.472.699.587.200.500.625]  +

 
Amino Acids, Peptides, and Proteins [D12]
   Peptides [D12.644]
      Peptide Hormones [D12.644.548]
         Pancreatic Hormones [D12.644.548.586]
            Insulins [D12.644.548.586.200]
               Proinsulin [D12.644.548.586.200.500]
Arrow pointing to current tree nodeC-Peptide [D12.644.548.586.200.500.250]
Insulin [D12.644.548.586.200.500.625]  +

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