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Janus Kinases
MeSH HeadingJanus Kinases
Tree NumberD08.811.913.696.620.682.725.124
Tree NumberD12.776.476.393
Scope NoteA family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.
Entry TermJAK Kinases
Allowable QualifiersAD AE AI AN BI BL CF CH CL CS CT DE DF DU EC GE HI IM IP ME PD PH PK PO RE SD SE ST TO TU UL UR
Registry NumberEC 2.7.10.2
History Note2007
Date of Entry20060705
Unique IDD053612


MeSH Tree Structures

 
Enzymes and Coenzymes [D08]
   Enzymes [D08.811]
      Transferases [D08.811.913]
         Phosphotransferases [D08.811.913.696]
            Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
               Protein Kinases [D08.811.913.696.620.682]
                  Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Focal Adhesion Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.049]  +
Arrow pointing to current tree nodeJanus Kinases [D08.811.913.696.620.682.725.124]
Janus Kinase 1 [D08.811.913.696.620.682.725.124.100]
Janus Kinase 2 [D08.811.913.696.620.682.725.124.200]
Janus Kinase 3 [D08.811.913.696.620.682.725.124.300]
TYK2 Kinase [D08.811.913.696.620.682.725.124.650]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]  +
Proto-Oncogene Proteins c-fes [D08.811.913.696.620.682.725.300]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]  +
Proto-Oncogene Proteins c-abl [D08.811.913.696.620.682.725.500]  +
src-Family Kinases [D08.811.913.696.620.682.725.800]  +
ZAP-70 Protein-Tyrosine Kinase [D08.811.913.696.620.682.725.900]

 
Amino Acids, Peptides, and Proteins [D12]
   Proteins [D12.776]
      Intracellular Signaling Peptides and Proteins [D12.776.476]
3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]  +
3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]  +
Activating Transcription Factor 6 [D12.776.476.011]
Adaptor Proteins, Signal Transducing [D12.776.476.024]  +
Adenylate Cyclase [D12.776.476.050]
AMP-Activated Protein Kinases [D12.776.476.062]
Apoptosis Regulatory Proteins [D12.776.476.075]  +
Axin Signaling Complex [D12.776.476.081]  +
Calcineurin [D12.776.476.087]
Calcium-Calmodulin-Dependent Protein Kinases [D12.776.476.100]  +
Casein Kinases [D12.776.476.150]  +
Class I Phosphatidylinositol 3-Kinases [D12.776.476.162]  +
Class II Phosphatidylinositol 3-Kinases [D12.776.476.168]
Class III Phosphatidylinositol 3-Kinases [D12.776.476.171]  +
Cold Shock Proteins and Peptides [D12.776.476.175]
Cyclic Nucleotide-Regulated Protein Kinases [D12.776.476.200]  +
Cyclin-Dependent Kinase Inhibitor Proteins [D12.776.476.225]  +
Cyclin-Dependent Kinases [D12.776.476.250]  +
Cyclins [D12.776.476.262]  +
Dual-Specificity Phosphatases [D12.776.476.268]  +
eIF-2 Kinase [D12.776.476.275]
Focal Adhesion Protein-Tyrosine Kinases [D12.776.476.287]
G-Protein-Coupled Receptor Kinases [D12.776.476.293]  +
Glycogen Synthase Kinases [D12.776.476.300]  +
GTP-Binding Protein Regulators [D12.776.476.325]  +
Guanylate Cyclase [D12.776.476.350]
Heterotrimeric GTP-Binding Proteins [D12.776.476.375]  +
I-kappa B Kinase [D12.776.476.378]
I-kappa B Proteins [D12.776.476.381]
Interleukin-1 Receptor-Associated Kinases [D12.776.476.384]
Intracellular Calcium-Sensing Proteins [D12.776.476.387]  +
Arrow pointing to current tree nodeJanus Kinases [D12.776.476.393]
Janus Kinase 1 [D12.776.476.393.100]
Janus Kinase 2 [D12.776.476.393.200]
Janus Kinase 3 [D12.776.476.393.300]
TYK2 Kinase [D12.776.476.393.650]
Lim Kinases [D12.776.476.396]
MAP Kinase Kinase Kinases [D12.776.476.400]  +
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]  +
Mitogen-Activated Protein Kinase Phosphatases [D12.776.476.445]  +
Mitogen-Activated Protein Kinases [D12.776.476.450]  +
Monomeric GTP-Binding Proteins [D12.776.476.525]  +
Mucin-4 [D12.776.476.534]
Olfactory Marker Protein [D12.776.476.543]
p21-Activated Kinases [D12.776.476.548]
Phosphatidylethanolamine Binding Protein [D12.776.476.555]
Phosphoinositide Phospholipase C [D12.776.476.556]  +
Phospholipase C gamma [D12.776.476.558]
Protein Phosphatase 2 [D12.776.476.561]
Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]  +
Proto-Oncogene Proteins c-akt [D12.776.476.565]
Proto-Oncogene Proteins c-fyn [D12.776.476.571]
PTEN Phosphohydrolase [D12.776.476.590]
Receptor-Like Protein Tyrosine Phosphatases [D12.776.476.592]  +
rho-Associated Kinases [D12.776.476.595]
Ribosomal Protein S6 Kinases [D12.776.476.600]  +
SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]  +
Sirtuins [D12.776.476.900]  +
TOR Serine-Threonine Kinases [D12.776.476.925]
ZAP-70 Protein-Tyrosine Kinase [D12.776.476.950]

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