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NIH Clinical Alerts and Advisories

NLM began offering clinical alert notices online in January 1991. Clinical alerts are provided to expedite the release of findings from the NIH-funded clinical trials where such release could significantly affect morbidity and mortality. Links to clinical alerts are provided below.

There are currently:
small yellow graphic indicating a new Clinical Alert34 clinical alerts 
8 clinical advisories

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Clinical Alerts

Commonly Used Three-drug Regimen for Idiopathic Pulmonary Fibrosis Found Harmful
NIH Stops One Treatment Arm of Trial; Other Two Treatments to Continue
National Heart, Lung, and Blood Institute (NHLBI)
October 21, 2011

Angioplasty Combined with Stenting Plus Aggressive Medical Therapy vs. Aggressive Medical Therapy Alone for Intracranial Arterial Stenosis: NINDS Stops Trial Enrollment Due to a Higher Risk of Stroke and Death in the Stented Group
National Institute of Neurological Disorders and Stroke (NINDS)
April 11, 2011

NHLBI Stops Study of Treatment for Pulmonary Hypertension in Patients with Sickle Cell Disease Due to Safety Concerns
National Heart, Lung, and Blood Institute (NHLBI)
July 28, 2009

Immunizations Are Discontinued in Two HIV Vaccine Trials
National Institute of Allergy and Infectious Diseases (NIAID)
September 21, 2007

International HIV/AIDS Trial Finds Continuous Antiretroviral Therapy Superior to Episodic Therapy
National Institute of Allergy and Infectious Diseases (NIAID)
January 18, 2006

Use of Non-Steroidal Anti-Inflammatory Drugs Suspended in Large Alzheimer's Disease Prevention Trial
National Institute on Aging (NIA)
December 22, 2004

NHLBI Stops Study Testing How Long Children with Sickle Cell Anemia Should Have Blood Transfusions to Prevent Stroke
National Heart, Lung, and Blood Institute (NHLBI)
December 6, 2004

NIH Asks Participants in Women’s Health Initiative Estrogen-Alone Study to Stop Study Pills, Begin Follow-up Phase
National Heart, Lung, and Blood Institute (NHLBI)
March 2, 2004

New Treatment Significantly Improves Long-term Outlook For Breast Cancer Survivors:
International clinical trial concludes women should consider taking letrozole after five years of tamoxifen treatment to continue to reduce risk of recurrence
National Cancer Institute (NCI)
October 9, 2003

Low Dose Warfarin Prevents Recurrence of Blood Clots - NHLBI Stops Study
National Heart, Lung, and Blood Institute (NHLBI)
February 24, 2003

NHLBI Stops Trial of Estrogen Plus Progestin Due to Increased Breast Cancer Risk, Lack of Overall Benefit
National Heart, Lung, and Blood Institute (NHLBI)
July 09, 2002

NHLBI-Funded Emphysema Study Finds Certain Patients at High Risk for Death Following Lung Surgery
National Heart, Lung, and Blood Institute (NHLBI)
August 15, 2001

Diet and Exercise Dramatically Delay Type 2 Diabetes; Diabetes Medication Metformin Also Effective
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
August 8, 2001

Chronic Lyme Disease Symptoms Not Helped by Intensive Antibiotic Treatment
National Institute of Allergy and Infectious Disease (NIAID)
June 12, 2001

Enbrel® Shown Safe, Effective in Children and Teenagers with Juvenile Rheumatoid Arthritis
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
March 17, 2000

NHLBI Stops Part of Study - High Blood Pressure Drug Performs No Better Than Standard Treatment
National Heart, Lung, and Blood Institute (NHLBI)
March 8, 2000

Periodic Transfusions Lower Stroke Risk in Children with Sickle Cell Anemia
National Heart, Lung, and Blood Institute (NHLBI)
September 18, 1997

Adjuvant Therapy of Breast Cancer - Tamoxifen Update.
National Cancer Institute (NCI)
November 30, 1995

To Ophthalmologists -- Findings from the Endophthalmitis Vitrectomy Study (EVS).
National Eye Institute (NEI)
October 13, 1995

Bypass Over Angioplasty for Patients With Diabetes.
National Heart, Lung, and Blood Institute (NHLBI)
September 21, 1995

Drug Treatment for Sickle Cell Anemia Announced January 30, 1995.
National Heart, Lung, and Blood Institute (NHLBI)
January 30, 1995

National Eye Institute Announces Ischemic Optic Neuropathy Decompression Trial (IONDT) Findings.
National Eye Institute (NEI)
January 3, 1995

Clinical Advisory on Carotid Endarterectomy for Patients With Asymptomatic Carotid Artery Stenosis.
National Institute of Neurological Disorders and Stroke (NINDS)
September 28, 1994

Important Therapeutic Information on the Benefit of Zidovudine (AZT) for the Prevention of the Transmission of HIV from Mother to Infant.
National Institute of Allergy and Infectious Diseases (NIAID)
February 22, 1994

Important Therapeutic Information on Treatment of HIV Infection in HIV-Infected Patients Who Are Intolerant of or Have Failed Zidovudine Therapy.
National Institute of Allergy and Infectious Diseases (NIAID)
February 1, 1993

Findings from the Optic Neuritis Treatment Trial.
National Eye Institute (NEI)
February 28, 1992

Findings of the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial.
National Eye Institute (NEI)
October 29, 1991

Important Therapeutic Information on Prevention of Recurrent Pneumocystis Carinii Pneumonia in Persons with AIDS.
National Institute of Allergy and Infectious Diseases (NIAID)
October 21, 1991

Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.
National Heart, Lung, and Blood Institute (NHLBI)
July 31, 1991

Results of the NHLBI and NIA clinical trial of the efficacy of antihypertensive treatment for isolated systolic hypertension in those aged 60 years and older.
National Heart, Lung, and Blood Institute (NHLBI)
National Institute on Aging (NIA)
June 26, 1991

Benefits of adjuvant therapy for rectal cancer.
National Cancer Institute (NCI)
March 13, 1991

Benefit of carotid endarterectomy for patients with high-grade stenosis of the internal carotid artery.
National Institute of Neurological Disorders and Stroke (NINDS)
February 26, 1991

Results of the NICHD clinical trial of the efficacy of intravenous immunoglobulin (IVIG) for the prophylaxis of serious bacterial infections in symptomatic HIV-infected children.
National Institute of Child Health and Human Development (NICHD)
January 18, 1991

Clinical Advisories

Secondary Prevention of Small Subcortical Strokes Trial: NINDS Stops Treatment with Combination Antiplatelet Therapy (Clopidogrel plus Aspirin) Due to Higher Risk of Major Hemorrhage and Death
National Institute of Neurological Disorders and Stroke (NINDS)
September 19, 2011

NCI Issues Clinical Announcement for Preferred Method of Treatment for Advanced Ovarian Cancer
National Cancer Institute (NCI)
January 4, 2006

Important Interim Results from a Phase III, Randomized, Double-Blind Comparison of Three Protease-Inhibitor-Sparing Regimens for the Initial Treatment of HIV Infection (AACTG Protocol A5095)
National Institute of Allergy and Infectious Diseases (NIAID)
March 13, 2003

Women with Rare Lung Disease Found to Also Have High Prevalence of Meningiomas, First Study to Document Tumor Connection; Possible Hormonal Cause
National Heart, Lung, and Blood Institute (NHLBI)
October 18, 2001

Antioxidant Vitamins and Zinc Reduce Risk of Vision Loss from Age-Related Macular Degeneration
Same Nutrients Have No Effect on the Development of Cataract
National Eye Institute (NEI)
October 15, 2001

NIDCD/VA Clinical Trial Finding Can Benefit Millions with Hearing Loss
National Institute on Deafness and Other Communication Disorders (NIDCD)
October 10, 2000

Treating Hypertension in the Patient with Type 2 Diabetes
National Heart, Lung, and Blood Institute (NHLBI)
May 30, 2000

NHLBI Issues New Clinical Advisory on Systolic Blood Pressure
National Heart, Lung, and Blood Institute (NHLBI)
May 4, 2000

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