10540283 1999 12 17 1999 12 17 2006 11 15

0950-382X 34 1 1999 Oct Mol. Microbiol. Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein. 24-36 The nirIX gene cluster of Paracoccus denitrificans is located between the nir and nor gene clusters encoding nitrite and nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is soluble and apparently located in the periplasm, as judged by the predicted signal sequence. NirI and NirX are homologues of NosR and NosX, proteins involved in regulation of the expression of the nos gene cluster encoding nitrous oxide reductase in Pseudomonas stutzeri and Sinorhizobium meliloti. Analysis of a NirI-deficient mutant strain revealed that NirI is involved in transcription activation of the nir gene cluster in response to oxygen limitation and the presence of N-oxides. The NirX-deficient mutant transiently accumulated nitrite in the growth medium, but it had a final growth yield similar to that of the wild type. Transcription of the nirIX gene cluster itself was controlled by NNR, a member of the family of FNR-like transcriptional activators. An NNR binding sequence is located in the middle of the intergenic region between the nirI and nirS genes with its centre located at position -41.5 relative to the transcription start sites of both genes. Attempts to complement the NirI mutation via cloning of the nirIX gene cluster on a broad-host-range vector were unsuccessful, the ability to express nitrite reductase being restored only when the nirIX gene cluster was reintegrated into the chromosome of the NirI-deficient mutant via homologous recombination in such a way that the wild-type nirI gene was present directly upstream of the nir operon. Department of Molecular Cell Physiology, Faculty of Biology, BioCentrum Amsterdam, Vrije Universiteit, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands. Saunders N F NF Houben E N EN Koefoed S S de Weert S S Reijnders W N WN Westerhoff H V HV De Boer A P AP Van Spanning R J RJ eng GENBANK AF005358 U47133 U94899 PDB P33943 Journal Article Research Support, Non-U.S. Gov't

ENGLAND Mol Microbiol 8712028 0 Bacterial Proteins 0 DNA-Binding Proteins 0 Membrane Proteins 0 NNR protein, Paracoccus denitrificans 0 NirI protein, Paracoccus denitrificans 0 NirX protein, Paracoccus denitrificans 0 Transcription Factors EC 1.7.- Nitrite Reductases IM Amino Acid Sequence Bacterial Proteins Base Sequence DNA-Binding Proteins Gene Expression Regulation, Bacterial Genetic Complementation Test Membrane Proteins chemistry genetics metabolism Molecular Sequence Data Multigene Family Mutation Nitrite Reductases genetics metabolism Paracoccus denitrificans genetics metabolism Protein Structure, Secondary Sequence Homology, Amino Acid Transcription Factors genetics metabolism Transcription, Genetic 10612833 2000 01 20 2000 01 20 2008 11 21

1098-1004 15 1 2000 Jan Hum. Mutat. Erratum: analysis of DNA elements that modulate myosin VIIa expression in humans. 114-5 Usher syndromeIb (USH1B), an autosomal recessive disorder caused by mutations in myosin VIIa (MYO7A), is characterized by congenital profound hearing loss, vestibular abnormalities and retinitis pigmentosa. Promoter elements in the 5 kb upstream of the translation start were identified using adult retinal pigment epithelium cells (ARPE-19) as a model system. A 160 bp minimal promoter within the first intron was active in ARPE-19 cells, but not in HeLa cells that do not express MYO7A. A 100 bp sequence, 5' of the first exon, and repeated with 90% homology within the first intron, appeared to modulate expression in both cell lines. Segments containing these elements were screened by heteroduplex analysis. No heteroduplexes were detected in the minimal promoter, suggesting that this sequence is conserved. A -2568 A>T transversion in the 5' 100 bp repeat, eliminating a CCAAT element, was found only in USH1B patients. However, in all 5 families, -2568 A>T was in cis with the same missense mutation in the myosin VIIa tail (Arg1240Gln), and 4 of the 5 families were Dutch. These observations suggest either 1) linkage disequilibrium or 2)that a combination of a promoter mutation with a less active myosin VIIa protein results in USH1B. Copyright 2000 Wiley-Liss, Inc. Center for Hereditary Communication Disorders, Boys Town National Research Hospital Omaha, NE, USA. ortend@boystown.org Orten D J DJ Weston M D MD Kelley P M PM Cremers C W CW Wagenaar M M Jacobson S G SG Kimberling W J WJ eng DC00677 DC NIDCD NIH HHS United States DC00982 DC NIDCD NIH HHS United States DC03351 DC NIDCD NIH HHS United States Corrected and Republished Article Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

UNITED STATES Hum Mutat 9215429 EC 3.6.1.33 myosin VIIa EC 3.6.1.4 Myosins EC 3.6.4.2 Dynein ATPase IM Hum Mutat. 1999 Oct;14(4):354 10502787 Amino Acid Substitution Cell Line Dynein ATPase Gene Expression Regulation Hearing Loss, Sensorineural genetics metabolism Hela Cells Humans Linkage Disequilibrium Mutation, Missense Myosins biosynthesis genetics Pedigree Pigment Epithelium of Eye metabolism Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Promoter Regions, Genetic Retinitis Pigmentosa genetics metabolism Syndrome Vestibular Diseases genetics metabolism 10737756 2000 04 13 2000 04 13 2004 11 17

0022-2623 43 6 2000 Mar 23 J. Med. Chem. Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs. 1234-41 The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the presence of N-methyl-D-glucamine afforded 2-(S)-(1-(R)-(3, 5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-(2- phosphoryl-3-oxo-4H,-1,2,4-triazolo)methylmorpholine, bis(N-methyl-D-glucamine) salt, 11. Incubation of 11 in rat, dog, and human plasma and in human hepatic subcellular fractions in vitro indicated that conversion to 2 would be expected to occur in vivo most readily in humans during hepatic circulation. Conversion of 11 to 2 occurred rapidly in vivo in the rat and dog with the levels of 11 being undetectable within 5 min after 1 and 8 mg/kg doses iv in the rat and within 15 min after 0.5, 2, and 32 mg/kg doses iv in the dog. Compound 11 has a 10-fold lower affinity for the human NK-1 receptor as compared to 2, but it is functionally equivalent to 2 in preclinical models of NK-1-mediated inflammation in the guinea pig and cisplatin-induced emesis in the ferret, indicating that 11 acts as a prodrug of 2. Based in part on these data, 11 was identified as a novel, water-soluble prodrug of the clinical candidate 2 suitable for intravenous administration in humans. Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Merck, Sharp & Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K. jeffrey_hale@merck.com Hale J J JJ Mills S G SG MacCoss M M Dorn C P CP Finke P E PE Budhu R J RJ Reamer R A RA Huskey S E SE Luffer-Atlas D D Dean B J BJ McGowan E M EM Feeney W P WP Chiu S H SH Cascieri M A MA Chicchi G G GG Kurtz M M MM Sadowski S S Ber E E Tattersall F D FD Rupniak N M NM Williams A R AR Rycroft W W Hargreaves R R Metzger J M JM MacIntyre D E DE eng Journal Article

UNITED STATES J Med Chem 9716531 0 2-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluoro)phenyl-4-(5-(2-phosphoryl-3-oxo-4H,-1,2,4-triazolo))methylmorpholine, bis(N-methylglucamine) salt 0 Acetals 0 Anti-Inflammatory Agents, Non-Steroidal 0 Antiemetics 0 Antineoplastic Agents 0 L 754030 0 Morpholines 0 Prodrugs 0 Receptors, Neurokinin-1 15663-27-1 Cisplatin 7732-18-5 Water IM Acetals chemical synthesis chemistry metabolism pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal chemical synthesis chemistry metabolism pharmacology Antiemetics chemical synthesis chemistry metabolism pharmacology Antineoplastic Agents Cisplatin Dogs Drug Evaluation, Preclinical Ferrets Guinea Pigs Humans Morpholines chemical synthesis chemistry metabolism pharmacology Prodrugs chemical synthesis chemistry metabolism pharmacology Rats Receptors, Neurokinin-1 antagonists & inhibitors Solubility Stereoisomerism Structure-Activity Relationship Vomiting chemically induced drug therapy Water 10854512 2000 06 29 2000 06 29 2004 11 17

1432-2218 14 1 2000 Jan Inflammatory fibroid polyp of the duodenum. 86 Duodenal inflammatory fibroid polyps (IFP) are extemely rare lesions indistinguishable from submucosal tumors by endoscopic inspection alone. Like gastric inflammatory fibroid polyps, they can be managed by endoscopic polypectomy or mucosectomy. However, preoperative diagnosis of this benign lesion is difficult. Here we present a case of duodenal IFP causing gastrointestinal bleeding that was evaluated by endoscopic ultrasound before surgical removal. On endosonography, the duodenal IFP appeared as a coarsely heterogeneous isoechoic and hypoechoic mass circumscribed by a distinct margin and arising from the third layer of the duodenal wall. The endosonographic appearance of this lesion was in marked contrast to that previously reported for gastric IFPs, which have tended to appear as hypoechoic homogeneous lesions with indistinct margins. Endosonographic evaluation of suspected IFPs before endoscopic or surgical treatment is useful. However, the endosonographic appearances of duodenal and gastric IFPs may be significantly different, possibly because of differences in the makeup of the duodenal and gastric walls. Division of Gastroenterology, ChangHua Christian Medical Center, ChangHua, Taiwan. Soon M S MS Lin O S OS eng Case Reports Journal Article 1999 11 25

UNITED STATES Surg Endosc 8806653 IM Duodenal Neoplasms complications pathology surgery Duodenitis etiology pathology surgery Endoscopy, Gastrointestinal Endosonography Female Fibroma pathology surgery Gastric Mucosa pathology Gastrointestinal Hemorrhage etiology pathology surgery Humans Intestinal Polyps complications pathology surgery Middle Aged 10972993 2000 09 26 2000 09 26 2008 11 21

0899-1987 28 4 2000 Aug Mol. Carcinog. Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines. 236-46 Germline mutations of BRCA1 and BRCA2 predispose to hereditary breast, ovarian, and possibly prostate cancer, yet structural mutations in these genes are infrequent in sporadic cancer cases. To better define the involvement of these genes in sporadic cancers, we characterized expression levels of BRCA1 and BRCA2 transcripts in cancer cell lines derived from neoplasms of the ovary, prostate, and breast and compared them with those expressed in primary cultures of normal epithelial cells established from these organs. We observed upregulation of BRCA1 and/or BRCA2 expression in six of seven ovarian cancer cell lines (OVCA420, OVCA429, OVCA432, ALST, DOV13, and SKOV3) when compared with levels found in normal ovary surface epithelial cells. Furthermore, five cancerous or immortalized prostatic epithelial cell lines (BPH-1, TSU-Pr1, LNCaP, PC-3, and DU145) also expressed higher levels of BRCA1 and/or BRCA2 mRNA than did primary cultures of normal prostatic epithelial cells. In contrast, only the estrogen receptor-positive MCF-7 cell line overexpressed these messages, whereas the estrogen receptor-negative breast cancer cell lines Hs578T, MDA-MB-231, and MDA-MB-468 showed no change in expression levels when compared with normal breast epithelial cells. In addition, expanding on our recent identification of a novel BRCA2 transcript variant carrying an in-frame exon 12 deletion (BRCA2 delta 12), we report increased expression of this variant in several ovarian, prostate, and mammary cancer cell lines (OVCA420, OVCA433, ALST, DOV13, SKOV3, TSU-Pr1, DU145, and MDA-MB-468). Most notably, high levels of BRCA2 delta 12 mRNA were detected in an estrogen receptor-positive breast cancer cell line, MCF-7, and in an androgen-independent prostate cancer cell line, DU-145. Interestingly, the wild-type BRCA2 transcript was barely detectable in DU145, which could be used as a model system for future investigations on BRCA2 delta 12 function. Taken together, our data suggest disruption of BRCA1 and/or BRCA2 gene expression in certain epithelial cancer cell lines of the ovary, prostate, and breast. Because wild-type BRCA1 and BRCA2 gene products increase during cell-cycle progression and are believed to exert growth-inhibitory action, enhanced expression of these genes in cancer cells may represent a negative feedback mechanism for curbing proliferation in fast-growing cells. At present, the functionality of BRCA2 delta 12 remains elusive. Copyright 2000 Wiley-Liss, Inc. Department of Biology, Tufts University, Medford, Massachusetts, USA. Rauh-Adelmann C C Lau K M KM Sabeti N N Long J P JP Mok S C SC Ho S M SM eng C69453 PHS HHS United States CA15576 CA NCI NIH HHS United States CA62269 CA NCI NIH HHS United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

UNITED STATES Mol Carcinog 8811105 0 BRCA1 Protein 0 BRCA2 Protein 0 Neoplasm Proteins 0 RNA, Messenger 0 Transcription Factors IM BRCA1 Protein genetics BRCA2 Protein Breast metabolism Breast Neoplasms genetics Cell Line Epithelial Cells metabolism Exons Female Gene Expression Regulation, Neoplastic Genes, BRCA1 Genetic Variation Humans Male Neoplasm Proteins genetics Ovarian Neoplasms genetics Prostatic Neoplasms genetics RNA, Messenger genetics Sequence Deletion Transcription Factors genetics Transcription, Genetic Tumor Cells, Cultured 11025314 2001 01 05 2001 01 05 2006 11 15

0108-2701 56 ( Pt 10) 2000 Oct Multicentre hydrogen bonds in a 2:1 arylsulfonylimidazolone hydrochloride salt. 1247-50 The title compound, (S)-(+)-4-[5-(2-oxo-4, 5-dihydroimidazol-1-ylsulfonyl)indolin-1 -ylcarbonyl ]anilinium chloride (S)-(+)-1-[1-(4-aminobenzoyl)indoline-5- sulfonyl]-4-phenyl-4, 5-dihydroimidazol-2-one, C(24)H(23)N(4)O(4)S(+).Cl(-). C(24)H(22)N(4)O(4)S, crystallizes in space group C2 from a CH(3)OH/CH(2)Cl(2) solution. In the crystal structure, there are two different conformers with their terminal C(6) aromatic rings mutually oriented at angles of 67.69 (14) and 61.16 (15) degrees. The distances of the terminal N atoms (of the two conformers) from the chloride ion are 3.110 (4) and 3.502 (4) A. There are eight distinct hydrogen bonds, i.e. four N-H...Cl, three N-H...O and one N-H...N, with one N-H group involved in a bifurcated hydrogen bond with two acceptors sharing the H atom. C-H...O contacts assist in the overall hydrogen-bonding process. College of Pharmacy, Chungnam National University, Taejeon 305-764, Korea. parki@cnu.ac.kr. Park K L KL Moon B G BG Jung S H SH Kim J G JG Suh I H IH eng Journal Article Research Support, Non-U.S. Gov't

DENMARK Acta Crystallogr C 8305826 0 1-(1-(4-aminobenzoyl)indoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazol-2-one 0 Antineoplastic Agents 0 Imidazoles 0 Sulfones IM Antineoplastic Agents chemistry Crystallography, X-Ray Hydrogen Bonding Imidazoles chemistry Models, Molecular Molecular Conformation Stereoisomerism Sulfones chemistry 11056631 2000 12 01

0031-9007 85 19 2000 Nov 6 Phys. Rev. Lett. Dislocated epitaxial islands. 4088-91 Dislocation networks observed in CoSi (2) islands grown epitaxially on Si are compared with the results of dislocation-dynamics calculations. The calculations make use of the fact that image forces play a relatively minor role compared to line tension forces and dislocation-dislocation interactions. Remarkable agreement is achieved, demonstrating that this approach can be applied more generally to study dislocations in other mesostructures. IBM Watson Research Center, P.O. Box 218, Yorktown Heights, New York 10598, USA. Liu X H XH Ross F M FM Schwarz K W KW eng Journal Article

UNITED STATES Phys Rev Lett 0401141 IM 11034741 2001 01 26 2001 08 02 2007 11 15

1469-493X 4 2000 Parent-training programmes for improving maternal psychosocial health. CD002020 BACKGROUND: The prevalence of mental health problems in women is 1:3 and such problems tend to be persistent. There is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for the psychological health of the child. It is now thought that parenting programmes may have an important role to play in the improvement of maternal psychosocial health. OBJECTIVES: The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression and self-esteem. SEARCH STRATEGY: A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR). SELECTION CRITERIA: Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health. DATA COLLECTION AND ANALYSIS: A systematic critical appraisal of all included studies was undertaken using the Journal of the American Medical Association (JAMA) published criteria. The data were summarised using effect sizes but were not combined in a meta-analysis due to the small number of studies within each group and the presence of significant heterogeneity. MAIN RESULTS: A total of 22 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. These 17 studies reported on a total of 59 outcomes including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. Approximately 22% of the outcomes measured suggested significant differences favouring the intervention group. A further 40% showed differences favouring the intervention group but which failed to achieve conventional levels of statistical significance, in some cases due to the small numbers that were used. Approximately 38% of outcomes suggested no evidence of effectiveness. REVIEWER'S CONCLUSIONS: It is suggested that parenting programmes can make a significant contribution to the improvement of psychosocial health in mothers. While the critical appraisal suggests some variability in the quality of the included studies, it is concluded that there is sufficient evidence to support their use with diverse groups of parents. However, it is also suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required. Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Oxford, UK, OX3 7LF. esther.coren@dphpc.ox.ac.uk Barlow J J Coren E E eng Journal Article Review

England Cochrane Database Syst Rev 100909747 IM Cochrane Database Syst Rev. 2001;(2):CD002020 11406024 Anxiety therapy Depression therapy Female Humans Maternal Behavior psychology Mother-Child Relations Parenting Program Evaluation Randomized Controlled Trials as Topic Self Concept 99 11237011 2001 03 09 2001 03 22 2006 11 15

0028-0836 409 6822 2001 Feb 15 Nature Initial sequencing and analysis of the human genome. 860-921 The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence. Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA. lander@genome.wi.mit.edu Lander E S ES Linton L M LM Birren B B Nusbaum C C Zody M C MC Baldwin J J Devon K K Dewar K K Doyle M M FitzHugh W W Funke R R Gage D D Harris K K Heaford A A Howland J J Kann L L Lehoczky J J LeVine R R McEwan P P McKernan K K Meldrim J J Mesirov J P JP Miranda C C Morris W W Naylor J J Raymond C C Rosetti M M Santos R R Sheridan A A Sougnez C C Stange-Thomann N N Stojanovic N N Subramanian A A Wyman D D Rogers J J Sulston J J Ainscough R R Beck S S Bentley D D Burton J J Clee C C Carter N N Coulson A A Deadman R R Deloukas P P Dunham A A Dunham I I Durbin R R French L L Grafham D D Gregory S S Hubbard T T Humphray S S Hunt A A Jones M M Lloyd C C McMurray A A Matthews L L Mercer S S Milne S S Mullikin J C JC Mungall A A Plumb R R Ross M M Shownkeen R R Sims S S Waterston R H RH Wilson R K RK Hillier L W LW McPherson J D JD Marra M A MA Mardis E R ER Fulton L A LA Chinwalla A T AT Pepin K H KH Gish W R WR Chissoe S L SL Wendl M C MC Delehaunty K D KD Miner T L TL Delehaunty A A Kramer J B JB Cook L L LL Fulton R S RS Johnson D L DL Minx P J PJ Clifton S W SW Hawkins T T Branscomb E E Predki P P Richardson P P Wenning S S Slezak T T Doggett N N Cheng J F JF Olsen A A Lucas S S Elkin C C Uberbacher E E Frazier M M Gibbs R A RA Muzny D M DM Scherer S E SE Bouck J B JB Sodergren E J EJ Worley K C KC Rives C M CM Gorrell J H JH Metzker M L ML Naylor S L SL Kucherlapati R S RS Nelson D L DL Weinstock G M GM Sakaki Y Y Fujiyama A A Hattori M M Yada T T Toyoda A A Itoh T T Kawagoe C C Watanabe H H Totoki Y Y Taylor T T Weissenbach J J Heilig R R Saurin W W Artiguenave F F Brottier P P Bruls T T Pelletier E E Robert C C Wincker P P Smith D R DR Doucette-Stamm L L Rubenfield M M Weinstock K K Lee H M HM Dubois J J Rosenthal A A Platzer M M Nyakatura G G Taudien S S Rump A A Yang H H Yu J J Wang J J Huang G G Gu J J Hood L L Rowen L L Madan A A Qin S S Davis R W RW Federspiel N A NA Abola A P AP Proctor M J MJ Myers R M RM Schmutz J J Dickson M M Grimwood J J Cox D R DR Olson M V MV Kaul R R Raymond C C Shimizu N N Kawasaki K K Minoshima S S Evans G A GA Athanasiou M M Schultz R R Roe B A BA Chen F F Pan H H Ramser J J Lehrach H H Reinhardt R R McCombie W R WR de la Bastide M M Dedhia N N Blöcker H H Hornischer K K Nordsiek G G Agarwala R R Aravind L L Bailey J A JA Bateman A A Batzoglou S S Birney E E Bork P P Brown D G DG Burge C B CB Cerutti L L Chen H C HC Church D D Clamp M M Copley R R RR Doerks T T Eddy S R SR Eichler E E EE Furey T S TS Galagan J J Gilbert J G JG Harmon C C Hayashizaki Y Y Haussler D D Hermjakob H H Hokamp K K Jang W W Johnson L S LS Jones T A TA Kasif S S Kaspryzk A A Kennedy S S Kent W J WJ Kitts P P Koonin E V EV Korf I I Kulp D D Lancet D D Lowe T M TM McLysaght A A Mikkelsen T T Moran J V JV Mulder N N Pollara V J VJ Ponting C P CP Schuler G G Schultz J J Slater G G Smit A F AF Stupka E E Szustakowski J J Thierry-Mieg D D Thierry-Mieg J J Wagner L L Wallis J J Wheeler R R Williams A A Wolf Y I YI Wolfe K H KH Yang S P SP Yeh R F RF Collins F F Guyer M S MS Peterson J J Felsenfeld A A Wetterstrand K A KA Patrinos A A Morgan M J MJ de Jong P P Catanese J J JJ Osoegawa K K Shizuya H H Choi S S Chen Y J YJ Szustakowki J J International Human Genome Sequencing Consortium eng Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

England Nature 0410462 0 DNA Transposable Elements 0 Proteins 0 Proteome 63231-63-0 RNA IM Nature. 2001 Feb 15;409(6822):814-6 11236992 Nature. 2001 Feb 15;409(6822):818-20 11236994 Nature. 2001 Feb 15;409(6822):820-1 11236995 Nature. 2001 Feb 15;409(6822):822-3 11236997 Nature. 2001 Oct 18;413(6857):660 11606985 Nature 2001 Aug 2;412(6846):565 Nature 2001 Jun 7;411(6838):720 Szustakowki, J [corrected to Szustakowski, J] Animals Chromosome Mapping Conserved Sequence CpG Islands DNA Transposable Elements Databases, Factual Drug Industry Evolution, Molecular Forecasting GC Rich Sequence Gene Duplication Genes Genetic Diseases, Inborn Genetics, Medical Genome, Human Human Genome Project Humans Mutation Private Sector Proteins genetics Proteome Public Sector RNA genetics Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA methods Species Specificity 11243089 2001 03 12 2001 05 17 2006 11 15

0019-557X 43 1 1999 Jan-Mar Nutritional status of pavement dweller children of Calcutta City. 49-54 Pavement dwelling is likely to aggravate malnutrition among its residents due to extreme poverty, lack of dwelling and access to food and their exposure to polluted environment. Paucity of information about nutritional status of street children compared to that among urban slum dwellers, squatters or rural/tribal population is quite evident. The present study revealed the magnitude of Protein Energy Malnutrition (PEM) and few associated factors among a sample of 435 underfives belonging to pavement dweller families and selected randomly from clusters of such families, from each of the five geographical sectors of Calcutta city. Overall prevalence of PEM was found almost similar (about 70%) to that among other 'urban poor' children viz. slum dwellers etc., but about 16% of them were found severely undernourished (Grade III & V of IAP classification of PEM). About 35% and 70% of street dweller children had wasting and stunting respectively. Severe PEM (Grade III & IV) was more prevalent among 12-23 months old, girl child, those belonged to illiterate parents and housewife mothers rather than wage earners. It also did increase with increase of birth rate of decrease of birth interval. Department of Community Medicine, Medical College, Calcutta. Ray S K SK Mishra R R Biswas R R Kumar S S Halder A A Chatterjee T T eng Journal Article Research Support, Non-U.S. Gov't

India Indian J Public Health 0400673 IM J Child, Preschool Cluster Analysis Cross-Sectional Studies Educational Status Female Humans India epidemiology Infant Male Nutritional Status Poverty Prejudice Prevalence Protein-Energy Malnutrition epidemiology 143717 00288124 This document presents a cross-sectional survey concerning the magnitude of protein energy malnutrition (PEM) and its associated factors among 435 under-5 pavement-dwelling children in Calcutta. Results revealed that 69.43% were undernourished and that 16% of them were suffering from severe malnutrition (grade III and IV of the Indian Academy of Pediatrics criteria for PEM). The 24-35 month age group had the highest prevalence of malnutrition (82.93%) followed by the 36-47 and 12-23 month age groups with prevalences of 76.19% and 74.03%, respectively. Prevalence of severe grade malnutrition was noted to be three times higher in females (24.76%) than males (8.45%), and among families it increased in direct proportion to birth rate and inverse proportion to birth interval. Moreover, children of illiterate parents and nonworking mothers had a higher incidence of severe PEM. Simple measures such as exclusive breast-feeding and timely complementary feeding as well as measures directed toward birth spacing and limiting family size should be implemented to solve the problem of malnutrition. Age Factors Asia Child Child Nutrition Demographic Factors Developing Countries Diseases Geographic Factors Health Homeless Persons India Malnutrition Nutrition Nutrition Disorders Population Population Characteristics Research Methodology Research Report Residence Characteristics Sampling Studies Southern Asia Spatial Distribution Studies Surveys Urban Population Youth TJ: INDIAN JOURNAL OF PUBLIC HEALTH. 11238657 2001 03 12 2001 05 17 2006 11 15

0022-1767 166 6 2001 Mar 15 J. Immunol. Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. 4083-91 Increasing evidence suggests that a continuous release of histamine from mast cells occurs in the airways of asthmatic patients and that histamine may modulate functions of other inflammatory cells such as macrophages. In the present study histamine (10(-9)-10(-6) M) increased in a concentration-dependent fashion the basal release of beta-glucuronidase (EC(50) = 8.2 +/- 3.5 x 10(-9) M) and IL-6 (EC(50) = 9.3 +/- 2.9 x 10(-8) M) from human lung macrophages. Enhancement of beta-glucuronidase release induced by histamine was evident after 30 min and peaked at 90 min, whereas that of IL-6 required 2-6 h of incubation. These effects were reproduced by the H(1) agonist (6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptane carboxamide but not by the H(2) agonist dimaprit. Furthermore, histamine induced a concentration-dependent increase of intracellular Ca(2+) concentrations ([Ca(2+)](i)) that followed three types of response, one characterized by a rapid increase, a second in which [Ca(2+)](i) displays a slow but progressive increase, and a third characterized by an oscillatory pattern. Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). These data demonstrate that histamine induces exocytosis and IL-6 production from human macrophages by activating H(1) receptor and by increasing [Ca(2+)](i) and they suggest that histamine may play a relevant role in the long-term sustainment of allergic inflammation in the airways. Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy. triggian@unina.it Triggiani M M Gentile M M Secondo A A Granata F F Oriente A A Taglialatela M M Annunziato L L Marone G G eng Journal Article Research Support, Non-U.S. Gov't

United States J Immunol 2985117R 0 Histamine Agonists 0 Histamine H1 Antagonists 0 Histamine H2 Antagonists 0 Interleukin-6 0 RNA, Messenger 0 Receptors, Histamine H1 0 Toluidines 103827-15-2 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide 51-45-6 Histamine 65119-89-3 Dimaprit 7440-70-2 Calcium EC 3.2.1.31 Glucuronidase AIM IM Calcium metabolism physiology Cytosol metabolism Dimaprit pharmacology Dose-Response Relationship, Immunologic Exocytosis immunology Glucuronidase secretion Histamine analogs & derivatives pharmacology physiology Histamine Agonists pharmacology Histamine H1 Antagonists pharmacology Histamine H2 Antagonists pharmacology Humans Interleukin-6 biosynthesis genetics secretion Lung cytology enzymology immunology metabolism Macrophages, Alveolar enzymology immunology metabolism secretion RNA, Messenger biosynthesis Receptors, Histamine H1 metabolism Toluidines pharmacology Up-Regulation immunology 11279676 2001 03 30 2001 12 07 2007 11 15

1469-493X 1 2001 Elective versus selective caesarean section for delivery of the small baby. CD000078 BACKGROUND: Elective caesarean delivery for women in preterm labour might reduce the chances of fetal or neonatal death, but it might also increase the risk of maternal morbidity. OBJECTIVES: To assess the effects of a policy of elective caesarean delivery versus selective caesarean delivery for women in preterm labour. SEARCH STRATEGY: The Cochrane Pregnancy and Childbirth Group trials register was searched. Date of last search: September 2000. SELECTION CRITERIA: Randomised trials comparing a policy of elective caesarean delivery versus expectant management with recourse to caesarean section. DATA COLLECTION AND ANALYSIS: One reviewer assessed eligibility and trial quality, and both contributed to the update. MAIN RESULTS: Six studies involving 122 women were included. All trials reported recruiting difficulties. No significant differences between elective and selective policies for caesarean delivery were found for fetal, neonatal or maternal outcomes. REVIEWER'S CONCLUSIONS: There is not enough evidence to evaluate the use of a policy for elective caesarean delivery for small babies. Randomised trials in this area are likely to continue to experience recruitment problems. However, it still may be possible to investigate elective caesarean delivery in preterm babies with cephalic presentations. Health Services Research Unit, The Polwarth Building, Foresterhill, Aberdeen, UK, AB9 2ZD. a.grant@abdn.ac.uk Grant A A Glazener C M CM eng Journal Article Review

England Cochrane Database Syst Rev 100909747 IM Cochrane Database Syst Rev. 2001;(2):CD000078 11405950 Cochrane Database Syst Rev. 2000;(2):CD000078 10796117 Cesarean Section Female Humans Infant, Newborn Infant, Premature Obstetric Labor, Premature Pregnancy Randomized Controlled Trials as Topic Surgical Procedures, Elective 21 11406024 2001 06 14 2002 02 28 2007 11 15

1469-493X 2 2001 Parent-training programmes for improving maternal psychosocial health. CD002020 BACKGROUND: Mental health problems are common, and there is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for both the short and long-term psychological health of the child. The use of parenting programmes is increasing in the UK and evidence of their effectiveness in improving outcomes for mothers is now required. OBJECTIVES: The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression, and self-esteem. SEARCH STRATEGY: A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR). SELECTION CRITERIA: Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health. DATA COLLECTION AND ANALYSIS: A systematic critical appraisal of all included studies was undertaken using a modified version of the Journal of the American Medical Association (JAMA) published criteria. The treatment effect for each outcome in each study was standardised by dividing the mean difference in post-intervention scores for the intervention and treatment group, by the pooled standard deviation, to produce an effect size. Where appropriate the results were then combined in a meta-analysis using a fixed-effect model, and 95% confidence intervals were used to assess the significance of the findings. MAIN RESULTS: A total of 23 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. The 17 studies provided a total of 59 assessments of outcome on a range of aspects of psychosocial functioning including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. There was only sufficient data, however, on five outcomes (depression; anxiety/stress; self-esteem; social support; and relationship with spouse/marital adjustment) to combine the results in a meta-analysis. The meta-analyses show statistically significant results favouring the intervention group as regards depression; anxiety/stress; self-esteem; and relationship with spouse/marital adjustment. The meta-analysis of the social support data, however, showed no evidence of effectiveness. These results suggest that parenting programmes, irrespective of the type (or content) of programme, can be effective in improving important aspects of maternal psycho-social functioning. Of the data summarising the effectiveness of the different types of parenting programmes, which it was not possible to combine in a meta-analysis, approximately 22% of the outcomes measured, showed significant differences between the intervention group and the control group. A further 40% showed medium to large non-significant differences favouring the intervention group. Approximately one-third of outcomes showed small non-significant differences or no evidence of effectiveness. A meta-analysis of the follow-up data on three outcomes was also conducted - depression, self-esteem and relationship with spouse/marital adjustment. The results show that there was a continued improvement in self-esteem, depression and marital adjustment at follow-up, although the latter two findings were not statistically significant. REVIEWER'S CONCLUSIONS: It is suggested that parenting programmes can make a significant contribution to short-term psychosocial health in mothers, and that the limited follow-up data available suggest that these are maintained over time. However, the overall paucity of long-term follow-up data points to the need for further evidence concerning the long-term effectiveness of parenting programmes on maternal mental health. Furthermore, it is suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required. Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. esther.coren@public-health.oxford.ac.uk Barlow J J Coren E E eng Journal Article Review

England Cochrane Database Syst Rev 100909747 IM Cochrane Database Syst Rev. 2004;(1):CD002020 14973981 Cochrane Database Syst Rev. 2000;(4):CD002020 11034741 Anxiety therapy Depression therapy Female Humans Maternal Behavior psychology Maternal Welfare Mother-Child Relations Parenting Program Evaluation Randomized Controlled Trials as Topic Self Concept 100 11428848 2001 06 28 2001 09 27 2007 11 15

0195-668X 22 13 2001 Jul Eur. Heart J. Indications for implantable cardioverter defibrillator (ICD) therapy. Study Group on Guidelines on ICDs of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing of the European Society of Cardiology. 1074-81 Heart Lung Center Utrecht, University Medical Center, The Netherlands. Hauer R N RN Aliot E E Block M M Capucci A A Lüderitz B B Santini M M Vardas P E PE European Society of Cardiology. Working Group on Arrhythmias and Working Group on Cardiac Pacing eng Guideline Journal Article Practice Guideline

England Eur Heart J 8006263 IM Arrhythmias, Cardiac etiology therapy Arrhythmogenic Right Ventricular Dysplasia therapy Cardiomyopathy, Dilated therapy Cardiomyopathy, Hypertrophic therapy Coronary Disease therapy Death, Sudden, Cardiac prevention & control Defibrillators, Implantable Heart Valve Diseases therapy Humans Long QT Syndrome therapy Ventricular Fibrillation therapy 11441930 2001 07 09 2001 07 19 2009 05 12

0284-186X 40 2-3 2001 Acta Oncol Assessment of quality of life during chemotherapy. 175-84 Increasingly more aggressive chemotherapy together with expected small differences between treatments with respect to objective endpoints has heightened awareness about the importance of addressing how patients experience and value the impact that treatment has had on their overall life situation. Assessment of a patient's quality of life (QoL) is now conceptually viewed as an important complement to traditional objective evaluation measures. It was therefore considered important to review the basis for the assessment of this endpoint when The Swedish Council of Technology Assessment in Health Care (SBU) performed a systematic overview of chemotherapy effects in several tumour types. The group came to the following conclusions: QoL assessments, mostly by patient self-reporting in questionnaires, have come increasingly into use during the past decade. A number of general, cancer-specific and cancer diagnosis-specific instruments have been developed. There is at present little need for development of new cancer instruments, although specific treatment modalities and tumour types may need new additional modules. A predefined hypothesis should determine the instrument to be used. Since the selection of a QoL instrument in a specific study influences both the results and the conclusions, it is essential to carefully select the instrument or instruments that have the greatest likelihood of identifying relevant differences between treatment alternatives. Interpretation of QoL data is more difficult than interpretation of objective endpoints such as survival time, objective response rates or toxicity. Despite these difficulties, QoL analyses have provided new insights into the advantages and disadvantages of various treatments not provided by traditional end-points. Some palliative treatments seemingly increase patients' QoL despite side-effects or the lack of, or marginal, increases in survival. When using potentially curative chemotherapy, it is not a matter of when the treatment should be started, but rather when it should be concluded. When using less active chemotherapy, the expected small therapeutic gains must be weighed against the QoL costs of using the therapy: does the toxicity and/or the inconvenience of the proposed treatment justify the expected gain? When it is found that the strain on the patient is greater than the effects of the cancer, treatment must be discontinued. It is not possible to determine whether or not the advantages of palliative chemotherapy are worth their costs without knowledge about patients' personal values regarding the influence on factors of relevance for QoL. The mostly used QoL questionnaires do not consider individual preferences, which therefore need to be addressed in the dialogue with the patient. QoL assessment is clearly in need of further methodological improvement before this endpoint can be regarded as fully established with respect to ability to provide unequivocally useful data in clinical trials. The multitude of questionnaires, missing data, lack of pre-study hypotheses of relevant differences between treatments and data multiplicity giving a risk for chance findings are examples of serious methodological problems. Patient response-shifts over time further complicate the interpretation of the data. Thus, QoL data, also from seemingly well-performed clinical trials, have to be interpreted cautiously. The international development during recent years has aimed at creating increased standardization of QoL measures. This has created greater possibilities to compare results from different trials. Hopefully, this also implies that it will be possible to draw firmer conclusions from QoL measurements in recently completed or ongoing trials than has been the case previously. QoL assessments are resource demanding even when short standardized questionnaires are used. Since cancer patients also generally give priority to anticancer effects over toxicity and convenience, QoL assessments in clinical trials are motivated mainly in study settings comparing treatments without expected major differences of outcome in objective endpoints. Department of Oncology, University Hospital, Lund, Sweden. Gunnars B B Nygren P P Glimelius B B SBU-group. Swedish Council of Technology Assessment in Health Care eng Journal Article Review

Norway Acta Oncol 8709065 0 Antineoplastic Agents IM Antineoplastic Agents adverse effects therapeutic use Endpoint Determination Humans Neoplasms drug therapy Outcome Assessment (Health Care) Palliative Care Patient Satisfaction Quality of Life Questionnaires 112 11442735 2001 07 09 2001 10 04 2006 11 15

0303-6979 28 8 2001 Aug J. Clin. Periodontol. Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches. 753-61 AIM: In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated. MATERIAL AND METHODS: 105 adult patients with moderately advanced chronic periodontitis from 3 centres participated in the trial. Each patient had to present with at least 8 periodontal sites in 2 jaw quadrants with a probing pocket depth (PPD) of > or =5 mm and bleeding following pocket probing (BoP), out of which at least 2 sites had to be > or =7 mm and a further 2 sites > or =6 mm. Following a baseline examination, including assessments of plaque, PPD, clinical attachment level (CAL) and BoP, careful instruction in oral hygiene was given. The patients were then randomly assigned to one of two treatment groups: scaling/root planing (SRP) with local analgesia or debridement (supra- and subgingival ultrasonic instrumentation without analgesia). The "SRP" group received a single episode of full-mouth supra-/subgingival scaling and root planing under local analgesia. In addition, at a 3-month recall visit, a full-mouth supra-/subgingival debridement using ultrasonic instrumentation was provided. This was followed by subgingival application of an 8.5% w/w doxycycline polymer at sites with a remaining PPD of > or =5 mm. The patients of the "debridement" group were initially subjected to a 45-minute full-mouth debridement with the use of an ultrasonic instrument and without administration of local analgesia, and followed by application of doxycycline in sites with a PPD of > or =5 mm. At month 3, sites with a remaining PPD of > or =5 mm were subjected to scaling and root planing. Clinical re-examinations were performed at 3 and 6 months. RESULTS: At 3 months, the proportion of sites showing PPD of < or =4 mm was significantly higher in the "debridement" group than in the "SRP" group (58% versus 50%; p<0.05). The CAL gain at 3 months amounted to 0.8 mm in the "debridement" group and 0.5 mm in the "SRP" group (p=0.064). The proportion of sites demonstrating a clinically significant CAL gain (> or =2 mm) was higher in the "debridement" group than in the "SRP" group (38% versus 30%; p<0.05). At the 6-month examination, no statistically significant differences in PPD or CAL were found between the two treatment groups. BoP was significantly lower for the "debridement" group than for the "SRP" group (p<0.001) both at 3- and 6 months. The mean total treatment time (baseline and 3-month) for the "SRP" patients was 3:11 h, compared to 2:00 h for the patients in the "debridement" group (p<0.001). CONCLUSION: The results indicate that simplified subgingival instrumentation combined with local application of doxycycline in deep periodontal sites can be considered as a justified approach for non-surgical treatment of chronic periodontitis. Department of Periodontology, Institute of Odontology, Göteborg University, SE 405 30 Göteborg, Sweden. wennstrom@odontologi.gu.se Wennström J L JL Newman H N HN MacNeill S R SR Killoy W J WJ Griffiths G S GS Gillam D G DG Krok L L Needleman I G IG Weiss G G Garrett S S eng fre ger Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Denmark J Clin Periodontol 0425123 0 Anti-Bacterial Agents 24390-14-5 doxycycline hyclate 564-25-0 Doxycycline D IM Adult Aged Anti-Bacterial Agents administration & dosage Chronic Disease Clinical Protocols Cost-Benefit Analysis Debridement Dental Scaling methods Doxycycline administration & dosage analogs & derivatives Drug Compounding Female Gingival Hemorrhage etiology Humans Male Middle Aged Periodontal Pocket pathology Periodontitis complications drug therapy pathology therapy Prospective Studies Root Planing methods Single-Blind Method Treatment Outcome 11488864 2001 08 07 2001 10 25 2006 11 15

0905-7161 12 4 2001 Aug Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit. 350-7 Textured implant surfaces are thought to enhance endosseous integration. Torque removal forces have been used as a biomechanical measure of anchorage, or endosseous integration, in which the greater forces required to remove implants may be interpreted as an increase in the strength of bony integration. The purpose of this study was to compare the torque resistance to removal of screw-shaped titanium implants having a dual acid-etched surface (Osseotite) with implants having either a machined surface, or a titanium plasma spray surface that exhibited a significantly more complex surface topography. Three custom screw-shaped implant types - machined, dual acid-etched (DAE), and titanium plasma sprayed (TPS) - were used in this study. Each implant surface was characterized by scanning electron microscopy and optical profilometry. One DAE implant was placed into each distal femur of eighteen adult New Zealand White rabbits along with one of the other implant types. Thus, each rabbit received two DAE implants and one each of the machined, or TPS, implants. All implants measured 3.25 mm in diameter x 4.00 mm in length without holes, grooves or slots to resist rotation. Eighteen rabbits were used for reverse torque measurements. Groups of six rabbits were sacrificed following one, two and three month healing periods. Implants were removed by reverse torque rotation with a digital torque-measuring device. Three implants with the machined surface preparation failed to achieve endosseous integration. All other implants were anchored by bone. Mean torque values for machined, DAE and TPS implants at one, two and three months were 6.00+/-0.64 N-cm, 9.07+/-0.67 N-cm and 6.73+/-0.95 N-cm; 21.86+/-1.37 N-cm, 27.63+/-3.41 N-cm and 27.40+/-3.89 N-cm; and 27.48+/-1.61 N-cm, 44.28+/-4.53 N-cm and 59.23+/-3.88 N-cm, respectively. Clearly, at the earliest time point the stability of DAE implants was comparable to that of TPS implants, while that of the machined implants was an order of magnitude lower. The TPS implants increased resistance to reverse torque removal over the three-month period. The results of this study confirm our previous results that demonstrated enhanced bony anchorage to dual acid-etched implants as compared to machined implants. Furthermore, the present results indicate that dual acid etching of titanium enhances early endosseous integration to a level which is comparable to that achieved by the topographically more complex TPS surfaces. Division of Associated Specialties, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA 90095, USA. pklok@ucla.edu Klokkevold P R PR Johnson P P Dadgostari S S Caputo A A Davies J E JE Nishimura R D RD eng fre ger Comparative Study Journal Article Research Support, Non-U.S. Gov't

Denmark Clin Oral Implants Res 9105713 0 Coated Materials, Biocompatible 0 Dental Implants 0 Sulfuric Acids 7440-32-6 Titanium 7647-01-0 Hydrochloric Acid 7664-93-9 sulfuric acid D Analysis of Variance Animals Coated Materials, Biocompatible Dental Implantation, Endosseous Dental Implants Dental Polishing Dental Prosthesis Design Device Removal Femur Hydrochloric Acid Implants, Experimental Metallurgy Osseointegration Rabbits Sulfuric Acids Surface Properties Titanium Torque 11488868 2001 08 07 2001 10 25 2006 11 15

0905-7161 12 4 2001 Aug Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. 379-84 Porous beta-phase tricalcium phosphate particles (pTCP) (Cerasorb) were used in two patients to restore or augment alveolar bone prior to the placement of dental implants. In one patient, pTCP was used to fill a large alveolar defect in the posterior mandible after the removal of a residual cyst, and in another patient to augment the sinus floor. Biopsies were taken at the time of implant placement, 9.5 and 8 months after grafting, respectively, and processed for hard tissue histology. Goldner-stained histological sections showed considerable replacement of the bone substitute by bone and bone marrow. In the 9.5 months biopsy of the mandible, 34% of the biopsy consisted of mineralised bone tissue and 29% of remaining pTCP, while the biopsy at 8 months after sinus floor augmentation consisted of 20% mineralised bone and 44% remaining pTCP. Bone and osteoid were lying in close contact with the remaining pTCP and were also seen within the micropores of the grafted particles. Tartrate resistant-acid phosphatase (TRAP) multinuclear cells, presumably osteoclasts, were found surrounding, within and in close contact with the pTCP particles, suggesting active resorption of the bone substitute. Remodelling of immature woven bone into mature lamellar bone was also found. No histological signs of inflammation were detected. The limited data presented from these two cases suggest that this graft material, possibly by virtue of its porosity and chemical nature, may be a suitable bone substitute that can biodegrade and be replaced by new mineralising bone tissue. Department of Oral Cell Biology, ACTA, Vrije Universiteit, Vander Boechorststraat 7, 1081 BT Amsterdam, Netherlands. IR.Zerbo.Ocb.ACTA@med.vu.nl Zerbo I R IR Bronckers A L AL de Lange G L GL van Beek G J GJ Burger E H EH eng fre ger Case Reports Journal Article Research Support, Non-U.S. Gov't

Denmark Clin Oral Implants Res 9105713 0 Bone Substitutes 0 Calcium Phosphates 0 beta-tricalcium phosphate 7758-87-4 tricalcium phosphate D Absorbable Implants Aged Alveolar Ridge Augmentation methods Bone Regeneration drug effects Bone Substitutes pharmacology Calcium Phosphates pharmacology Humans Male Mandible surgery Maxillary Sinus surgery Middle Aged Oral Surgical Procedures, Preprosthetic Porosity 11520209 2001 08 24 2001 09 27 2004 11 17

0022-2623 44 18 2001 Aug 30 J. Med. Chem. Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity. 3001-13 This paper describes the synthesis of a series of azo compounds able to deliver 5-aminosalicylic acid (5-ASA) and a potent platelet activating factor (PAF) antagonist in a colon-specific manner for the purpose of treating ulcerative colitis. We found it possible to add an amino group on the aromatic moiety of our reported 1-[(1-acyl-4-piperidyl)methyl]-1H-2-methylimidazo[4,5-c]pyridine derivatives or on British Biotech compounds BB-882 and BB-823 maintaining a high level of activity as PAF antagonist. A selected compound UR-12715 (49c) showed an IC(50) of 8 nM in the in vitro PAF-induced aggregation assay, and an ID(50) of 29 microg/kg in the in vivo PAF-induced hypotension test in normotensive rats. Through attachment of 49c to the 5-ASA via azo functionality we obtained UR-12746 (70). Pharmacokinetics experiments with [14C]-70 allow us to reach the following conclusions, critical in the design of these new prodrugs of 5-ASA. Neither the whole molecule 70 nor the carrier 49c were absorbed after oral administration of [14C]-70 in rat as was demonstrated by the absence of plasma levels of radioactivity and the high recovery of it in feces. Effective cleavage of azo bond (84%) by microflora in the colon is achieved. These facts ensure high topical concentrations of 5-ASA and 49c in the colon. Additionally, 70 exhibited a potent anticolitic effect in the trinitrobenzenesulfonic acid-induced colitis model in the rat. This profile suggests that UR-12746 (70) provides an attractive new approach to the treatment of ulcerative colitis. Research Center, J. Uriach & Cía.S.A., Degà Bahí 59-67, 08026 Barcelona, Spain. chem-carceller@uriach.com Carceller E E Salas J J Merlos M M Giral M M Ferrando R R Escamilla I I Ramis J J García-Rafanell J J Forn J J eng Journal Article

United States J Med Chem 9716531 0 1-((1-(3-(4-aminophenyl)-3-phenylpropenoyl)-4-piperidyl)methyl)-1H-2-methylimidazo(4,5-c)pyridine 0 Amines 0 Aminosalicylic Acids 0 Anti-Inflammatory Agents, Non-Steroidal 0 Aza Compounds 0 Azo Compounds 0 Imidazoles 0 Platelet Activating Factor 0 Prodrugs 0 Pyridines 0 UR 12746 2508-19-2 Trinitrobenzenesulfonic Acid 89-57-6 Mesalamine IM Amines chemical synthesis chemistry pharmacology Aminosalicylic Acids Animals Anti-Inflammatory Agents, Non-Steroidal chemical synthesis chemistry pharmacokinetics pharmacology Aza Compounds chemical synthesis chemistry pharmacology Azo Compounds chemical synthesis chemistry pharmacokinetics pharmacology Colitis, Ulcerative chemically induced drug therapy Drug Evaluation, Preclinical Female Hypotension drug therapy Imidazoles chemical synthesis chemistry pharmacology Male Mesalamine chemical synthesis chemistry pharmacology Platelet Activating Factor antagonists & inhibitors Platelet Aggregation drug effects Prodrugs chemical synthesis chemistry pharmacokinetics pharmacology Pyridines chemical synthesis chemistry pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Stereoisomerism Structure-Activity Relationship Trinitrobenzenesulfonic Acid 11525160 2001 08 28 2001 08 30 2004 11 17

0250-5525 124 2000 32nd Annual meeting of the Swiss Society of Nephrology. Lausanne, 14-15 December 2000. Abstracts. 1S-20S eng fre ger Congresses Overall

Switzerland Schweiz Med Wochenschr Suppl 7708316 IM Animals Humans Kidney Diseases Nephrology 11524736 2001 08 28 2001 12 12 2006 11 15

1098-1004 18 3 2001 Sep Hum. Mutat. Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome. 251 Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases. Hum Mutat 18:251, 2001. Copyright 2001 Wiley-Liss, Inc. Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk Comeglio P P Evans A L AL Brice G W GW Child A H AH eng Journal Article Research Support, Non-U.S. Gov't

United States Hum Mutat 9215429 0 Microfilament Proteins 0 fibrillin IM Hum Mutat. 2001 Dec;18(6):546-7 11748851 Adult Base Sequence Child, Preschool Female Frameshift Mutation Great Britain Humans Male Marfan Syndrome genetics Microfilament Proteins genetics Middle Aged Mutation Mutation, Missense Sequence Deletion 11543891 2001 09 06 2001 09 27 2006 11 15

0198-8859 62 9 2001 Sep Hum. Immunol. The origin of Palestinians and their genetic relatedness with other Mediterranean populations. 889-900 The genetic profile of Palestinians has, for the first time, been studied by using human leukocyte antigen (HLA) gene variability and haplotypes. The comparison with other Mediterranean populations by using neighbor-joining dendrograms and correspondence analyses reveal that Palestinians are genetically very close to Jews and other Middle East populations, including Turks (Anatolians), Lebanese, Egyptians, Armenians, and Iranians. Archaeologic and genetic data support that both Jews and Palestinians came from the ancient Canaanites, who extensively mixed with Egyptians, Mesopotamian, and Anatolian peoples in ancient times. Thus, Palestinian-Jewish rivalry is based in cultural and religious, but not in genetic, differences. The relatively close relatedness of both Jews and Palestinians to western Mediterranean populations reflects the continuous circum-Mediterranean cultural and gene flow that have occurred in prehistoric and historic times. This flow overtly contradicts the demic diffusion model of western Mediterranean populations substitution by agriculturalists coming from the Middle East in the Mesolithic-Neolithic transition. Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es Arnaiz-Villena A A Elaiwa N N Silvera C C Rostom A A Moscoso J J Gómez-Casado E E Allende L L Varela P P Martínez-Laso J J eng Comparative Study Journal Article Research Support, Non-U.S. Gov't Retracted Publication

United States Hum Immunol 8010936 0 HLA Antigens 0 HLA-A Antigens 0 HLA-B Antigens 0 HLA-DQ Antigens 0 HLA-DQB1 0 HLA-DR Antigens 128338-86-3 HLA-DRB1 antigen IM Hum Immunol. 2001 Oct;62(10):1064 11600211 Suciu-Foca N, Lewis R. Hum Immunol. 2001 Oct;62(10):1063 11600210 Alleles Arabs genetics Gene Frequency Greece ethnology HLA Antigens genetics HLA-A Antigens genetics HLA-B Antigens genetics HLA-DQ Antigens HLA-DR Antigens genetics Haplotypes genetics Humans Islam Israel Jews genetics Linkage Disequilibrium Mediterranean Region Middle East Phylogeny Polymorphism, Genetic genetics 11562649 2001 09 19 2002 02 22 2005 11 16

0891-5245 15 5 2001 Sep-Oct Educating parents about normal stool pattern changes in infants. 269-74 Pediatric Nurse Practitioner Program at Ohio State University College of Nursing, Columbus, USA. Arias A A Bennison J J Justus K K Thurman D D eng Journal Article Review

United States J Pediatr Health Care 8709735 N J Pediatr Health Care. 2001 Sep-Oct;15(5):270-1 11858131 Adolescent Child Child, Preschool Consumer Satisfaction Defecation Feces chemistry Health Education methods Humans Infant Infant, Newborn Ohio Parenting 13 11567133 2001 09 21 2001 10 04 2007 03 19

0036-8075 293 5538 2001 Sep 21 Science Changes in seismic anisotropy after volcanic eruptions: evidence from Mount Ruapehu. 2231-3 The eruptions of andesite volcanoes are explosively catastrophic and notoriously difficult to predict. Yet changes in shear waveforms observed after an eruption of Mount Ruapehu, New Zealand, suggest that forces generated by such volcanoes are powerful and dynamic enough to locally overprint the regional stress regime, which suggests a new method of monitoring volcanoes for future eruptions. These results show a change in shear-wave polarization with time and are interpreted as being due to a localized stress regime caused by the volcano, with a release in pressure after the eruption. Institute of Geophysics, Victoria University of Wellington, Wellington, New Zealand. Miller V V Savage M M eng Journal Article

United States Science 0404511 11473127 2001 09 24 2001 11 01 2004 11 17

0021-9258 276 39 2001 Sep 28 J. Biol. Chem. Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium. 36520-9 We have used the highly selective alpha(4)beta(1) inhibitor 2S-[(1-benzenesulfonyl-pyrrolidine-2S-carbonyl)-amino]-4-[4-methyl-2S-(methyl-[2-[4-(3-o-tolyl-ureido)-phenyl]-acetyl]-amino)-pentanoylamino]-butyric acid (BIO7662) as a model ligand to study alpha(4)beta(1) integrin-ligand interactions on Jurkat cells. Binding of [(35)S]BIO7662 to Jurkat cells was dependent on the presence of divalent cations and could be blocked by treatment with an excess of unlabeled inhibitor or with EDTA. K(D) values for the binding of BIO7662 to Mn(2+)-activated alpha(4)beta(1) and to the nonactivated state of the integrin that exists in 1 mm Mg(2+), 1 mm Ca(2+) were <10 pm, indicating that it has a high affinity for both activated and nonactivated integrin. No binding was observed on alpha(4)beta(1) negative cells. Through an analysis of the metal ion dependences of ligand binding, several unexpected findings about alpha(4)beta(1) function were made. First, we observed that Ca(2+) binding to alpha(4)beta(1) was stimulated by the addition of BIO7662. From solution binding studies on purified alpha(4)beta(1), two types of Ca(2+)-binding sites were identified, one dependent upon and the other independent of BIO7662 binding. Second, we observed that the metal ion dependence of ligand binding was affected by the affinity of the ligand for alpha(4)beta(1). ED(50) values for the metal ion dependence of the binding of BIO7762 and the binding of a lower affinity ligand, BIO1211, differed by 2-fold for Mn(2+), 30-fold for Mg(2+), and >1000-fold for Ca(2+). Low Ca(2+) (ED(50) = 5-10 microm) stimulated the binding of BIO7662 to alpha(4)beta(1). The effects of microm Ca(2+) closely resembled the effects of Mn(2+) on alpha(4)beta(1) function. Third, we observed that the rate of BIO7662 binding was dependent on the metal ion concentration and that the ED(50) for the metal ion dependence of BIO7662 binding was affected by the concentration of the BIO7662. These studies point to an even more complex interplay between metal ion and ligand binding than previously appreciated and provide evidence for a three-component coupled equilibrium model for metal ion-dependent binding of ligands to alpha(4)beta(1). Biogen, Inc., Cambridge, Massachusetts 02142, USA. Chen L L LL Whitty A A Scott D D Lee W C WC Cornebise M M Adams S P SP Petter R C RC Lobb R R RR Pepinsky R B RB eng Journal Article 2001 07 25

United States J Biol Chem 2985121R 0 2-((1-benzenesulfonylpyrrolidine-2-carbonyl)amino)-4-(4-methyl-2-(methyl-(2-(4-(3-o-tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acid 0 Benzoic Acids 0 Cations 0 Dipeptides 0 Integrin alpha4beta1 0 Integrins 0 Ions 0 Ligands 0 Phenylurea Compounds 0 Receptors, Lymphocyte Homing 60-00-4 Edetic Acid 7439-95-4 Magnesium 7439-96-5 Manganese 7440-70-2 Calcium IM Benzoic Acids pharmacology Calcium metabolism pharmacology Cations Dipeptides pharmacology Dose-Response Relationship, Drug Edetic Acid pharmacology Humans Integrin alpha4beta1 Integrins antagonists & inhibitors chemistry metabolism Ions Jurkat Cells Kinetics Ligands Magnesium pharmacology Manganese pharmacology Models, Chemical Phenylurea Compounds pharmacology Protein Binding Receptors, Lymphocyte Homing antagonists & inhibitors chemistry metabolism Time Factors 11583040 2001 10 02 2001 10 04 2006 11 15

0084-6597 28 2000 Understanding oblique impacts from experiments, observations, and modeling. 141-67 Natural impacts in which the projectile strikes the target vertically are virtually nonexistent. Nevertheless, our inherent drive to simplify nature often causes us to suppose most impacts are nearly vertical. Recent theoretical, observational, and experimental work is improving this situation, but even with the current wealth of studies on impact cratering, the effect of impact angle on the final crater is not well understood. Although craters' rims may appear circular down to low impact angles, the distribution of ejecta around the crater is more sensitive to the angle of impact and currently serves as the best guide to obliquity of impacts. Experimental studies established that crater dimensions depend only on the vertical component of the impact velocity. The shock wave generated by the impact weakens with decreasing impact angle. As a result, melting and vaporization depend on impact angle; however, these processes do not seem to depend on the vertical component of the velocity alone. Finally, obliquity influences the fate of the projectile: in particular, the amount and velocity of ricochet are a strong function of impact angle. Lunar and Planetary Lab., University of Arizona, Tucson, 84721, USA. betty@lpl.arizona.edu Pierazzo E E Melosh H J HJ eng Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

United States Annu Rev Earth Planet Sci 100971465 S Computer Simulation Evolution, Planetary Gravitation Meteoroids Models, Theoretical Moon Planets 96 00026602 NASA Discipline Exobiology Non-NASA Center Melosh H J HJ U AZ, Tucson Grant numbers: NAGW-5159, NAGW-428. 11580607 2001 10 02 2001 10 25 2006 11 15

0031-9007 87 13 2001 Sep 24 Phys. Rev. Lett. Maximal height scaling of kinetically growing surfaces. 136101 The scaling properties of the maximal height of a growing self-affine surface with a lateral extent L are considered. In the late-time regime its value measured relative to the evolving average height scales like the roughness: h*(L) approximately L alpha. For large values its distribution obeys logP(h*(L)) approximately (-)A(h*(L)/L(alpha))(a). In the early-time regime where the roughness grows as t(beta), we find h*(L) approximately t(beta)[lnL-(beta/alpha)lnt+C](1/b), where either b = a or b is the corresponding exponent of the velocity distribution. These properties are derived from scaling and extreme-value arguments. They are corroborated by numerical simulations and supported by exact results for surfaces in 1D with the asymptotic behavior of a Brownian path. Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA. Raychaudhuri S S Cranston M M Przybyla C C Shapir Y Y eng Journal Article Research Support, U.S. Gov't, Non-P.H.S. 2001 09 05

United States Phys Rev Lett 0401141 IM Bacteria growth & development Crystallization Kinetics Models, Theoretical Surface Properties 11600210 2001 10 15 2001 10 25

0198-8859 62 10 2001 Oct Hum. Immunol. Editorial. Anthropology and genetic markers. 1063 Suciu-Foca N N Lewis R R eng Retraction of Publication

United States Hum Immunol 8010936 IM Arnaiz-Villena A, Elaiwa N, Silvera C, Rostom A, Moscoso J, Gómez-Casado E, Allende L, Varela P, Martínez-Laso J. Hum Immunol. 2001 Sep;62(9):889-900 11543891 11600211 2001 10 15 2001 10 25 2004 11 17

0198-8859 62 10 2001 Oct Hum. Immunol. Letter from the ASHI president and council. 1064 Tyan D B DB eng Comment Letter

United States Hum Immunol 8010936 IM Hum Immunol. 2001 Sep;62(9):889-900 11543891 Ethics, Medical Histocompatibility Humans Immunogenetics Publishing Societies, Medical United States 11686176 1982 01 01 1982 01 01 2007 11 15

0094-6133 1979 Jan-Feb How physicians may minimize their chances of becoming involved in an informed consent claim. 1-2 Bower John J JJ eng Journal Article

United States Malpract Dig 9879884 E Consent Forms Humans Informed Consent Jurisprudence Malpractice Records as Topic 12517 KIE BoB Subject Heading: INFORMED CONSENT 11686167 1990 10 17 1990 10 17 2007 11 15

8756-2057 25-26 1990 Jan-Apr The dilemma of the Webster decision: deconstitutionalizing the trimester system. 276-92 Kindregan Charles P CP eng Journal Article

United States Report Hum Reprod Law 100971950 E Abortion, Eugenic Abortion, Induced Abortion, Therapeutic Beginning of Human Life Civil Rights Embryonic and Fetal Development Fetal Viability Fetus Government Regulation Great Britain History Humans International Cooperation Internationality Jurisprudence Legislation as Topic Life Pregnancy Pregnant Women Privacy Religion Social Control, Formal State Government Supreme Court Decisions United States 31521 Abortion Act 1967 (Great Britain) Genetics and Reproduction Legal Approach Roe v. Wade Webster v. Reproductive Health Services 63 fn. KIE BoB Subject Heading: abortion/legal aspects 11694165 2001 11 05 2001 12 28 2006 11 07

0098-7484 286 17 2001 Nov 7 JAMA msJAMA: Breast reconstruction: one woman's choice. 2163 Bily L L eng Journal Article

United States JAMA 7501160 AIM IM Body Image Decision Making Female Humans Mammaplasty methods psychology Mastectomy psychology 11704686 2001 11 19 2001 12 28 2005 11 16

0028-4793 345 22 2001 Nov 29 N. Engl. J. Med. Recognition and management of anthrax--an update. 1621-6 Department of Medicine, Massachusetts General Hospital, Boston 02114-2696, USA. Swartz M N MN eng Journal Article Review 2001 11 06

United States N Engl J Med 0255562 0 Anthrax Vaccines 0 Penicillins AIM IM N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5 11907299 N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5 11911136 N Engl J Med. 2002 Mar 21;346(12):943-5; discusson 943-5 11911137 N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5 11911138 N Engl J Med 2002 Feb 21;346(8):634 Anthrax diagnosis drug therapy epidemiology prevention & control Anthrax Vaccines Antibiotic Prophylaxis Bacillus anthracis pathogenicity Bioterrorism Diagnosis, Differential Gastrointestinal Diseases diagnosis microbiology Humans Infection Control methods Laboratory Techniques and Procedures Meningitis, Bacterial diagnosis microbiology Penicillins therapeutic use Respiratory Tract Infections diagnosis drug therapy microbiology Skin Diseases, Bacterial diagnosis microbiology Spores, Bacterial Virulence 11 11731716 2001 12 03 2002 02 28 2005 11 16

0031-7012 64 1 2002 Jan Pharmacology Progress in the search for ideal drugs. 1-7 The search for ideal drugs to improve patient care requires applications of modern scientific methods to both discovery and development. Using these modern methods, the pharmaceutical industry with strong academic and government collaboration has introduced in the last 25 years many new drugs that approach the ideal. After reviewing Björnsson's classification of drug action and the notion of contributory causality, this commentary defines an ideal drug from the perspectives of pharmacodynamics, pharmacokinetics, and therapeutics. Examples of new drugs for hypertension, heart disease, stroke, osteoporosis, asthma, ulcer, and migraine headaches are described. Finally, the profound implications of progress in developing ideal drugs not only for the patient but also for the academic, educational, and regulatory establishments are briefly reviewed. Copyright 2002 S. Karger AG, Basel Department of Medicine, Robert Wood Johnson Medical School, Piscataway, NJ, USA. Spector Reynold R eng Journal Article Review

Switzerland Pharmacology 0152016 0 Pharmaceutical Preparations IM Drug Industry Drug Therapy trends Humans Pharmaceutical Preparations classification Pharmacokinetics Pharmacology 25 11748851 2001 12 18 2002 03 07 2006 11 15

1098-1004 18 6 2001 Dec Hum. Mutat. Erratum: Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome. 546-7 Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases. Copyright 2001 Wiley-Liss, Inc. Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk Comeglio P P Evans A L AL Brice G W GW Child A H AH eng Corrected and Republished Article Journal Article Research Support, Non-U.S. Gov't

United States Hum Mutat 9215429 0 Microfilament Proteins 0 fibrillin 9007-49-2 DNA IM Hum Mutat. 2001 Sep;18(3):251 11524736 Adult Base Sequence Child, Preschool DNA chemistry genetics DNA Mutational Analysis Female Frameshift Mutation Great Britain Humans Male Marfan Syndrome genetics pathology Microfilament Proteins genetics Middle Aged Mutation Mutation, Missense Polymorphism, Genetic Polymorphism, Single-Stranded Conformational 11748856 2001 12 18 2002 03 07 2007 11 15

1098-1004 18 6 2001 Dec Hum. Mutat. Eight novel germline MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer families from Spain. 549 Germline mutations in the MLH1 and MSH2 genes, account for the majority of HNPCC families. We have screened such families from Spain by using DGGE analysis and subsequent direct sequencing techniques. In eight families we identified six novel MLH1 and two novel MSH2 mutations comprising one frame shift mutation (c.1420 del C), two missense mutations (L622H and R687W), two splice site mutations (c.1990-1 G>A and c.453+2 T>C and one nonsense mutation (K329X) in the MLH1 gene as well as two frame shift mutations (c.1979-1980 del AT and c.1704-1705 del AG) in the MSH2 gene. Our analysis contributes to the further characterization of the mutational spectrum of MLH1 and MSH2 genes in HNPCC families. Copyright 2001 Wiley-Liss, Inc. Laboratory of Molecular Oncology, San Carlos University Hospital, 28040 Madrid, Spain. Godino J J de La Hoya M M Diaz-Rubio E E Benito M M Caldés T T eng OMIM 114500 120435 120436 600258 600259 600678 Journal Article Research Support, Non-U.S. Gov't

United States Hum Mutat 9215429 0 Adaptor Proteins, Signal Transducing 0 Carrier Proteins 0 DNA-Binding Proteins 0 MLH1 protein, human 0 Neoplasm Proteins 0 Nuclear Proteins 0 Proto-Oncogene Proteins 9007-49-2 DNA EC 3.6.1.3 MSH2 protein, human EC 3.6.1.3 MutS Homolog 2 Protein IM Adaptor Proteins, Signal Transducing Carrier Proteins Colorectal Neoplasms, Hereditary Nonpolyposis genetics DNA chemistry genetics DNA Mutational Analysis DNA-Binding Proteins Family Health Female Germ-Line Mutation Humans Male MutS Homolog 2 Protein Neoplasm Proteins genetics Nuclear Proteins Proto-Oncogene Proteins genetics Spain 11885531 2002 02 05 2002 04 08 2006 11 15

0028-2200 99 7 1992 Jul [Microbiological diagnostics in periodontal treatment] 245-6 Periodontal diseases are bacterial infections. The rationale for the use of microbiological diagnostics in periodontal treatment of severe periodontitis patients is discussed as well as the use of adjunct antimicrobial therapy for the elimination of specific bacterial species. Uit de vakgroep Orale Microbiologie van het Academisch Centrum Tandheelkunde Amsterdam (ACTA). de Graaff J J van Winkelhoff A J AJ dut English Abstract Journal Article Review Microbiologische diagnostiek in de paradontologie.

Netherlands Ned Tijdschr Tandheelkd 0400771 0 Anti-Bacterial Agents D Actinomycetales Infections drug therapy Anti-Bacterial Agents therapeutic use Humans Hygiene Periodontal Diseases diagnosis drug therapy microbiology Periodontitis diagnosis drug therapy microbiology Risk Factors 6 12179763 1991 12 03 1991 12 03 2003 11 14

1226-0282 10 2 1990 Dec Recent changes in the population control policy and its future directions in Korea. 152-73 Cho N H NH Seo M H MH Tan B A BA eng Journal Article

KOREA, REPUBLIC OF Bogeon sahoe nonjib 9422396 J Adult Age Factors Aged Asia Birth Rate Conservation of Natural Resources Contraception Delivery of Health Care Demography Dependency (Psychology) Developing Countries Economics Employment Environment Family Planning Services Far East Fertility Health Health Manpower Health Planning Health Services Korea Maternal-Child Health Centers Organization and Administration Population Population Characteristics Population Density Population Dynamics Population Growth Primary Health Care Program Evaluation Public Policy Public Sector Research Social Welfare Socioeconomic Factors Sterilization, Reproductive 067656 00204408 The total fertility rate (TFR) in Korea decreased from 6.0 to 1.6 over the period 1960-87. A national family planning program and socioeconomic development have played roles in this decline. Should this most recent TFR prevail, the nation's population will increase to 50.2 million by 2020, shifting to negative growth thereafter. Demographic aging and labor shortages will ensue. Future population policy should consider Korea's socioeconomic conditions and its burgeoning population in relation to the available land area, and aim to maintain a minimum positive population growth rate. In this context, this paper considers future population policy directions for Korea, acknowledging that its strategies and objectives must change. Postponing reaching the goal of zero population growth rate is suggested to allow a moderate population infusion of economically active individuals. These people will help facilitate greater economic development and work to improve the quality of life in Korea. Strengthened family planning/maternal-child health programs which encourage and support temporary contraceptive methods instead of sterilization will help to achieve this goal. Improving qualitative program aspects should be the center of attention in these programs. The paper also calls upon the Korea Institute for Health and Social Affairs to strengthen its research and evaluation capabilities. Adult Age Factors Aged Asia Birth Rate Carrying Capacity Contraception Contraceptive Methods Delivery Of Health Care Demographic Aging Demographic Factors Demographic Transition Dependency Burden Developing Countries Eastern Asia Economic Development Economic Factors Environment Family Planning Family Planning Programs Fertility Fertility Measurements Fertility Rate Health Health Services Human Resources Korea Labor Force Macroeconomic Factors Maternal-child Health Services Microeconomic Factors Natural Resources Organization And Administration Policy Population Population Characteristics Population Decrease Population Dynamics Population Growth Population Policy Population Pressure Population Size Primary Health Care Program Evaluation Programs Public Sector Research Methodology Social Policy Social Welfare Socioeconomic Factors Sterilization, Sexual Total Fertility Rate--changes Zero Population Growth TJ: JOURNAL OF POPULATION, HEALTH AND SOCIAL WELFARE 12349809 2000 12 06 2000 12 06 2007 11 15

0251-7329 37 2 2000 Gender and globalization. A century in retrospect. 69-70 Chinkin C C eng Journal Article

UNITED STATES UN Chron 8305532 J Economics Evaluation Studies as Topic Interpersonal Relations Social Change Socioeconomic Factors Women's Rights 152034 00297373 In the past, power structures of the nation-State have been organized around patriarchal assumptions, granting men monopoly over power, authority, and wealth. A number of structures have been erected to achieve this imbalance, which have disguised its inequity by making it appear as natural and universal. However, with globalization, this centralization of power within the Sovereign State has been fragmented. Although globalization opens up new spaces by weakening the nation-State, subsequently making possible the undermining of traditional gender hierarchies and devising new bases for gender relations, the reality that the State is no longer the sole institution that can define identity and belonging within it has denied women the space to assert their own claims to gendered self-determination. In this regard, globalization has impacted upon gender relations in complex and contradictory ways. This paper discusses such impacts of globalization on gender relations. Overall, it has become apparent that forms of inequality still exist regardless of a State's prevailing political ideology. Their manifestations may differ, but the reality of women's subordination remains constant. Critique Economic Factors Gender Issues Gender Relations Social Change Socioeconomic Factors Women's Status World TJ: UN CHRONICLE 11831940 2002 02 08 2002 02 25 2004 11 17

0003-9950 120 2 2002 Feb Arch. Ophthalmol. Republication of color figures. 234-7 Dushku Nicholas N John Molykutty K MK Schultz Gregory S GS Reid Ted W TW eng Comment Letter

United States Arch Ophthalmol 7706534 EC 3.4.24.- Matrix Metalloproteinases AIM IM Arch Ophthalmol. 2001 May;119(5):695-706 11346397 Epithelial Cells enzymology pathology Fibroblasts enzymology pathology Humans Immunoenzyme Techniques Limbus Corneae pathology Matrix Metalloproteinases metabolism Pterygium enzymology pathology 11838066 2002 02 12 2002 02 25 2008 11 21

0023-7205 99 3 2002 Jan 17 Lakartidningen [Unequal distribution of health resources. Research is not supported with consideration to the global significance of the diseases] 148-9 josef.milerad@lakartidningen.se Milerad Josef J swe Biography Historical Article Journal Article Portraits Ojämn fördelning av hälsoresurser. Forskningspengar satsas inte i proportion till sjukdomars globala betydelse.

Sweden Lakartidningen 0027707 IM Health Care Rationing History, 20th Century Humans Nobel Prize Research Support as Topic economics organization & administration Sweden United States World Health Varmus Harold H 11858276 2002 02 21 2002 03 28 2008 11 21

0094-5765 48 5-12 2001 Mar-Jun Phase 1 research program overview. 845-51 The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd. NASA Johnson Space Center, Houston, TX, USA. Uri J J JJ Lebedev O N ON eng Journal Article

England Acta Astronaut 9890631 S Biological Science Disciplines Equipment Design Exobiology Extraterrestrial Environment Humans International Cooperation Program Evaluation Research instrumentation organization & administration Russia Space Flight instrumentation organization & administration trends Spacecraft USSR United States United States National Aeronautics and Space Administration organization & administration Weightlessness 00027286 Flight Experiment Mir Project STS Shuttle Project long duration manned short duration 11858625 2002 02 22 2002 03 06 2004 11 17

0002-838X 65 3 2002 Feb 1 Information from your family doctor. Exercise for the elderly. 427-8 eng Journal Article Patient Education Handout

United States Am Fam Physician 1272646 AIM IM Am Fam Physician. 2002 Feb 1;65(3):419-26 11858624 Aged Exercise Family Practice Health Promotion Humans 11869993 2002 02 28 2002 03 22 2004 11 17

1052-1577 27 4 2002 Feb By the way doctor... I'm 72 and was recently told that I am losing a bit of my sight because of macular degeneration. My doctor assured me that it was progressing very slowly, but also said there wasn't really anything to do about it. But I read that zinc or vitamins might help. Should I be taking them? 8 Lee Thomas H TH eng Journal Article

United States Harv Health Lett 9425764 0 Antioxidants 0 Vitamins 7440-66-6 Zinc K Aged Antioxidants therapeutic use Drug Therapy, Combination Humans Macular Degeneration prevention & control Vitamins therapeutic use Zinc therapeutic use 11876201 2002 03 04 2002 03 22 2007 11 15

1069-9422 5 3 1998 Consumer acceptance of vegetarian sweet potato products intended for space missions. 339-46 Sweet potato is one of the crops selected for NASA's Advanced Life Support Program for potential long-duration lunar/Mars missions. This article presents recipes of products made from sweet potato and determines the consumer acceptability of products containing from 6% to 20% sweet potato on a dry weight basis. These products were developed for use in nutritious and palatable meals for future space explorers. Sensory evaluation (appearance/color, aroma, texture, flavor/taste, and overall acceptability) studies were conducted to determine the consumer acceptability of vegetarian products made with sweet potato using panelists at NASA/Johnson Space Center in Houston, TX. None of these products including the controls, contained any ingredient of animal origin with the exception of sweet potato pie. A 9-point hedonic scale (9 being like extremely and 1 being dislike extremely) was used to evaluate 10 products and compare them to similar commercially available products used as controls. The products tested were pancakes, waffles, tortillas, bread, pie, pound cake, pasta, vegetable patties, doughnuts, and pretzels. All of the products were either liked moderately or liked slightly with the exception of the sweet potato vegetable patties, which were neither liked nor disliked. Mean comparisons of sensory scores of sweet potato recipes and their controls were accomplished by using the Student t-test. Because of their nutritional adequacy and consumer acceptability, these products are being recommended to NASA's Advanced Life Support Program for inclusion in a vegetarian menu plan designed for lunar/Mars space missions. Center for Food and Environmental Systems for Human Exploration of Space, George Washington Carver Agricultural Experiment Station, Tuskegee University, Tuskegee, AL 36088, USA. Wilson C D CD Pace R D RD Bromfield E E Jones G G Lu J Y JY eng Journal Article Research Support, U.S. Gov't, Non-P.H.S.

United States Life Support Biosph Sci 9431217 S Diet, Vegetarian psychology Ecological Systems, Closed Evaluation Studies as Topic Food Habits psychology Food Preferences psychology Food Technology Humans Ipomoea batatas Life Support Systems Menu Planning Nutritive Value Space Flight United States United States National Aeronautics and Space Administration Weightlessness 00027330 NASA Discipline Life Support Systems Non-NASA Center Mortley D G DG Tuskegee U, AL Grant numbers: NCC 9-51, ALX-FS-2. 11892742 2002 03 13 2002 03 18 2009 07 23

0012-1606 242 2 2002 Feb 15 Dev. Biol. The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis. 376-87 Recent studies on the structural composition of mammalian sperm heads have shown a congregate of unidentified proteins occupying the periphery of the mammalian sperm nucleus, forming a layer of condensed cytosol. These proteins are the perinuclear theca (PT) and can be categorized into SDS-soluble and SDS-insoluble components. The present study focused on identifying the major SDS-insoluble PT protein, which we localized to the subacrosomal layer of bovine spermatozoa and cloned by immunoscreening a bull testicular cDNA library. The isolated clones encode a protein of 122 amino acids that bears 67% similarity with histone H2B and contains a predicted histone fold motif. The novel amino terminus of the protein contains a potential bipartite nuclear targeting sequence. Hence, we identified this prominent subacrosomal component as a novel H2B variant, SubH2Bv. Northern blot analyses of SubH2Bv mRNA expression showed that it is testis-specific and is also present in murid testes. Immunocytochemical analysis showed SubH2Bv intimately associates, temporally and spatially, with acrosome formation. While the molecular features of SubH2Bv are common to nuclear proteins, it is never seen developmentally within the nucleus of the spermatid. Considering its developmental and molecular characteristics, we have postulated roles of SubH2Bv in acrosome assembly and acrosome-nuclear docking. Copyright 2001 Academic Press. Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada, K7L 3N6. Aul Ritu B RB Oko Richard J RJ eng Corrected and Republished Article Journal Article Research Support, Non-U.S. Gov't

United States Dev Biol 0372762 0 DNA, Complementary 0 Histones 0 RNA, Messenger 63231-63-0 RNA IM Dev Biol. 2001 Nov 15;239(2):376-87 11784042 Acrosome chemistry metabolism ultrastructure Amino Acid Motifs Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Western Cattle DNA, Complementary metabolism Electrophoresis, Polyacrylamide Gel Histones chemistry Immunoblotting Immunohistochemistry Male Mice Molecular Sequence Data RNA metabolism RNA, Messenger metabolism Rats Reverse Transcriptase Polymerase Chain Reaction Seminiferous Epithelium metabolism Sequence Homology, Amino Acid Spermatogenesis Spermatozoa chemistry Testis metabolism 11909345 2002 03 22 2002 05 16 2003 11 03

0031-9007 88 10 2002 Mar 11 Phys. Rev. Lett. Measurement of B --> K*gamma branching fractions and charge asymmetries. 101805 The branching fractions of the exclusive decays B0-->K(*0)gamma and B+-->K(*+)gamma are measured from a sample of (22.74+/-0.36)x10(6) BB decays collected with the BABAR detector at the PEP-II asymmetric e(+)e(-) collider. We find B (B0-->K(*0)gamma) = [4.23+/-0.40(stat)+/-0.22(syst)]x10(-5), B(B+-->K(*+)gamma) = [3.83+/-0.62(stat)+/-0.22(syst)]x10(-5) and constrain the CP-violating charge asymmetry to be -0.170<A(CP)(B-->K(*)gamma)<0.082 at 90% C.L. Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux, France. Aubert B B Boutigny D D Gaillard J-M JM Hicheur A A Karyotakis Y Y Lees J P JP Robbe P P Tisserand V V Palano A A Chen G P GP Chen J C JC Qi N D ND Rong G G Wang P P Zhu Y S YS Eigen G G Reinertsen P L PL Stugu B B Abbott B B Abrams G S GS Borgland A W AW Breon A B AB Brown D N DN Button-Shafer J J Cahn R N RN Clark A R AR Gill M S MS Gritsan A V AV Groysman Y Y Jacobsen R G RG Kadel R W RW Kadyk J J Kerth L T LT Kluth S S Kolomensky Yu G YG Kral J F JF LeClerc C C Levi M E ME Liu T T Lynch G G Meyer A B AB Momayezi M M Oddone P J PJ Perazzo A A Pripstein M M Roe N A NA Romosan A A Ronan M T MT Shelkov V G VG Telnov A V AV Wenzel W A WA Zisman M S MS Bright-Thomas P G PG Harrison T J TJ Hawkes C M CM Knowles D J DJ O'Neale S W SW Penny R C RC Watson A T AT Watson N K NK Deppermann T T Goetzen K K Koch H H Krug J J Kunze M M Lewandowski B B Peters K K Schmuecker H H Steinke M M Andress J C JC Barlow N R NR Bhimji W W Chevalier N N Clark P J PJ Cottingham W N WN De Groot N N Dyce N N Foster B B McFall J D JD Wallom D D Wilson F F FF Abe K K Hearty C C Mattison T S TS McKenna J A JA Thiessen D D Jolly S S McKemey A K AK Tinslay J J Blinov V E VE Bukin A D AD Bukin D A DA Buzykaev A R AR Golubev V B VB Ivanchenko V N VN Korol A A AA Kravchenko E A EA Onuchin A P AP Salnikov A A AA Serednyakov S I SI Skovpen Yu I YI Telnov V I VI Yushkov A N AN Best D D Lankford A J AJ Mandelkern M M McMahon S S Stoker D P DP Ahsan A A Arisaka K K Buchanan C C Chun S S Branson J G JG MacFarlane D B DB Prell S S Rahatlou Sh Sh Raven G G Sharma V V Campagnari C C Dahmes B B Hart P A PA Kuznetsova N N Levy S L SL Long O O Lu A A Richman J D JD Verkerke W W Witherell M M Yellin S S Beringer J J Dorfan D E DE Eisner A M AM Frey A A Grillo A A AA Grothe M M Heusch C A CA Johnson R P RP Kroeger W W Lockman W S WS Pulliam T T Sadrozinski H H Schalk T T Schmitz R E RE Schumm B A BA Seiden A A Turri M M Walkowiak W W Williams D C DC Wilson M G MG Chen E E Dubois-Felsmann G P GP Dvoretskii A A Hitlin D G DG Metzler S S Oyang J J Porter F C FC Ryd A A Samuel A A Weaver M M Yang S S Zhu R Y RY Devmal S S Geld T L TL Jayatilleke S S Mancinelli G G Meadows B T BT Sokoloff M D MD Barillari T T Bloom P P Dima M O MO Fahey S S Ford W T WT Johnson D R DR Nauenberg U U Olivas A A Park H H Rankin P P Roy J J Sen S S Smith J G JG van Hoek W C WC Wagner D L DL Blouw J J Harton J L JL Krishnamurthy M M Soffer A A Toki W H WH Wilson R J RJ Zhang J J Brandt T T Brose J J Colberg T T Dahlinger G G Dickopp M M Dubitzky R S RS Hauke A A Maly E E Müller-Pfefferkorn R R Otto S S Schubert K R KR Schwierz R R Spaan B B Wilden L L Behr L L Bernard D D Bonneaud G R GR Brochard F F Cohen-Tanugi J J Ferrag S S Roussot E E T'Jampens S S Thiebaux Ch Ch Vasileiadis G G Verderi M M Anjomshoaa A A Bernet R R Khan A A Lavin D D Muheim F F Playfer S S Swain J E JE Falbo M M Borean C C Bozzi C C Dittongo S S Folegani M M Piemontese L L Treadwell E E Anulli F F Baldini-Ferroli R R Calcaterra A A de Sangro R R Falciai D D Finocchiaro G G Patteri P P Peruzzi I M IM Piccolo M M Xie Y Y Zallo A A Bagnasco S S Buzzo A A Contri R R Crosetti G G Fabbricatore P P Farinon S S Lo Vetere M M Macri M M Monge M R MR Musenich R R Pallavicini M M Parodi R R Passaggio S S Pastore F C FC Patrignani C C Pia M G MG Priano C C Robutti E E Santroni A A Morii M M Bartoldus R R Dignan T T Hamilton R R Mallik U U Cochran J J Crawley H B HB Fischer P-A PA Lamsa J J Meyer W T WT Rosenberg E I EI Benkebil M M Grosdidier G G Hast C C Höcker A A Lacker H M HM Laplace S S Lepeltier V V Lutz A M AM Plaszczynski S S Schune M H MH Trincaz-Duvoid S S Valassi A A Wormser G G Bionta R M RM Brigljević V V VV Lange D J DJ Mugge M M Shi X X van Bibber K K Wenaus T J TJ Wright D M DM Wuest C R CR Carroll M M Fry J R JR Gabathuler E E Gamet R R George M M Kay M M Payne D J DJ Sloane R J RJ Touramanis C C Aspinwall M L ML Bowerman D A DA Dauncey P D PD Egede U U Eschrich I I Gunawardane N J W NJ Nash J A JA Sanders P P Smith D D Azzopardi D E DE Back J J JJ Dixon P P Harrison P F PF Potter R J L RJ Shorthouse H W HW Strother P P Vidal P B PB Williams M I MI Cowan G G George S S Green M G MG Kurup A A Marker C E CE McGrath P P McMahon T R TR Ricciardi S S Salvatore F F Scott I I Vaitsas G G Brown D D Davis C L CL Allison J J Barlow R J RJ Boyd J T JT Forti A C AC Fullwood J J Jackson F F Lafferty G D GD Savvas N N Simopoulos E T ET Weatherall J H JH Farbin A A Jawahery A A Lillard V V Olsen J J Roberts D A DA Schieck J R JR Blaylock G G Dallapiccola C C Flood K T KT Hertzbach S S SS Kofler R R Moore T B TB Staengle H H Willocq S S Brau B B Cowan R R Sciolla G G Taylor F F Yamamoto R K RK Milek M M Patel P M PM Trischuk J J Lanni F F Palombo F F Bauer J M JM Booke M M Cremaldi L L Eschenburg V V Kroeger R R Reidy J J Sanders D A DA Summers D J DJ Martin J P JP Nief J Y JY Seitz R R Taras P P Zacek V V Nicholson H H Sutton C S CS Cartaro C C Cavallo N N De Nardo G G Fabozzi F F Gatto C C Lista L L Paolucci P P Piccolo D D Sciacca C C LoSecco J M JM Alsmiller J R G JR Gabriel T A TA Handler T T Brau J J Frey R R Iwasaki M M Sinev N B NB Strom D D Colecchia F F Dal Corso F F Dorigo A A Galeazzi F F Margoni M M Michelon G G Morandin M M Posocco M M Rotondo M M Simonetto F F Stroili R R Torassa E E Voci C C Benayoun M M Briand H H Chauveau J J David P P de La Vaissière Ch Ch Del Buono L L Hamon O O Le Diberder F F Leruste Ph P Lory J J Roos L L Stark J J Versillé S S Manfredi P F PF Re V V Speziali V V Frank E D ED Gladney L L Guo Q H QH Panetta J H JH Angelini C C Batignani G G Bettarini S S Bondioli M M Carpinelli M M Forti F F Giorgi M A MA Lusiani A A Martinez-Vidal F F Morganti M M Neri N N Paoloni E E Rama M M Rizzo G G Sandrelli F F Simi G G Triggiani G G Walsh J J Haire M M Judd D D Paick K K Turnbull L L Wagoner D E DE Albert J J Bula C C Elmer P P Lu C C McDonald K T KT Miftakov V V Schaffner S F SF Smith A J S AJ Tumanov A A Varnes E W EW Cavoto G G del Re D D Faccini R R Ferrarotto F F Ferroni F F Fratini K K Lamanna E E Leonardi E E Mazzoni M A MA Morganti S S Piredda G G Safai Tehrani F F Serra M M Voena C C Christ S S Waldi R R Adye T T Franek B B Geddes N I NI Gopal G P GP Xella S M SM Aleksan R R De Domenico G G Emery S S Gaidot A A Ganzhur S F SF Giraud P-F PF Hamel Monchenault G G Kozanecki W W Langer M M London G W GW Mayer B B Serfass B B Vasseur G G Yèche Ch Ch Zito M M Copty N N Purohit M V MV Singh H H Yumiceva F X FX Adam I I Anthony P L PL Aston D D Baird K K Berger J P JP Bloom E E Boyarski A M AM Bulos F F Calderini G G Claus R R Convery M R MR Coupal D P DP Coward D H DH Dorfan J J Doser M M Dunwoodie W W Field R C RC Glanzman T T Godfrey G L GL Gowdy S J SJ Grosso P P Himel T T Hryn'ova T T Huffer M E ME Innes W R WR Jessop C P CP Kelsey M H MH Kim P P Kocian M L ML Langenegger U U Leith D W G S DW Luitz S S Luth V V Lynch H L HL Marsiske H H Menke S S Messner R R Moffeit K C KC Mount R R Muller D R DR O'Grady C P CP Perl M M Petrak S S Quinn H H Ratcliff B N BN Robertson S H SH Rochester L S LS Roodman A A Schietinger T T Schindler R H RH Schwiening J J Seeman J T JT Serbo V V VV Snyder A A Soha A A Spanier S M SM Stelzer J J Su D D Sullivan M K MK Tanaka H A HA Va'vra J J Wagner S R SR Weinstein A J R AJ Wienands U U Wisniewski W J WJ Wright D H DH Young C C CC Burchat P R PR Cheng C H CH Kirkby D D Meyer T I TI Roat C C De Silva A A Henderson R R Bugg W W Cohn H H Weidemann A W AW Izen J M JM Kitayama I I Lou X C XC Turcotte M M Bianchi F F Bona M M Di Girolamo B B Gamba D D Smol A A Zanin D D Bosisio L L Della Ricca G G Lanceri L L Pompili A A Poropat P P Vuagnin G G Panvini R S RS Brown C M CM Kowalewski R R Roney J M JM Band H R HR Charles E E Dasu S S Di Lodovico F F Eichenbaum A M AM Hu H H Johnson J R JR Liu R R Nielsen J J Pan Y Y Prepost R R Scott I J IJ Sekula S J SJ von Wimmersperg-Toeller J H JH Wu S L SL Yu Z Z Zobernig H H Kordich T M B TM Neal H H BABAR Collaborations eng Journal Article 2002 02 26

United States Phys Rev Lett 0401141 11916658 2002 03 27 2002 04 15 2007 11 15

1070-910X 9 7 2002 Mar By the way, doctor. A few months ago, I was surprised to read that a new study has raised a question about the value of screening mammograms. Is that true? I thought the importance of having such mammograms was well-established. I'm 52 and have been getting annual mammograms for 10 years. Should I stop? 8 Robb-Nicholson Celeste C eng Journal Article

United States Harv Womens Health Watch 9423147 K Breast Neoplasms mortality radiography Clinical Trials as Topic standards Female Humans Mammography Middle Aged Patient Education as Topic Research Design 11966386 2002 04 22 2002 05 02 2007 11 15

0098-7484 287 16 2002 Apr 24 JAMA The 2001 Bethesda System: terminology for reporting results of cervical cytology. 2114-9 OBJECTIVES: The Bethesda 2001 Workshop was convened to evaluate and update the 1991 Bethesda System terminology for reporting the results of cervical cytology. A primary objective was to develop a new approach to broaden participation in the consensus process. PARTICIPANTS: Forum groups composed of 6 to 10 individuals were responsible for developing recommendations for discussion at the workshop. Each forum group included at least 1 cytopathologist, cytotechnologist, clinician, and international representative to ensure a broad range of views and interests. More than 400 cytopathologists, cytotechnologists, histopathologists, family practitioners, gynecologists, public health physicians, epidemiologists, patient advocates, and attorneys participated in the workshop, which was convened by the National Cancer Institute and cosponsored by 44 professional societies. More than 20 countries were represented. EVIDENCE: Literature review, expert opinion, and input from an Internet bulletin board were all considered in developing recommendations. The strength of evidence of the scientific data was considered of paramount importance. CONSENSUS PROCESS: Bethesda 2001 was a year-long iterative review process. An Internet bulletin board was used for discussion of issues and drafts of recommendations. More than 1000 comments were posted to the bulletin board over the course of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to the public. Postworkshop recommendations were posted on the bulletin board for a last round of critical review prior to finalizing the terminology. CONCLUSIONS: Bethesda 2001 was developed with broad participation in the consensus process. The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology. EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA. ds87v@nih.gov Solomon Diane D Davey Diane D Kurman Robert R Moriarty Ann A O'Connor Dennis D Prey Marianne M Raab Stephen S Sherman Mark M Wilbur David D Wright Thomas T Jr Young Nancy N Forum Group Members Bethesda 2001 Workshop eng Consensus Development Conference Consensus Development Conference, NIH Guideline Journal Article Review

United States JAMA 7501160 AIM IM JAMA. 2002 Apr 24;287(16):2140-1 11966390 Cervical Intraepithelial Neoplasia classification pathology Female Humans Laboratories standards Quality Control Terminology as Topic Uterine Cervical Dysplasia classification pathology Uterine Cervical Neoplasms diagnosis pathology Vaginal Smears classification standards 28 11953811 2002 05 09 2002 05 24 2008 11 21

1432-2218 16 5 2002 May Disruptive visions: surgeon responsibility during the era of change. 733-4 Satava R M RM eng Editorial

Germany Surg Endosc 8806653 IM Biomedical Technology Commerce trends Delivery of Health Care trends General Surgery standards trends Health Services Needs and Demand trends Humans 12038483 2002 05 30 2002 07 26 2008 11 21

0273-1177 26 12 2000 Adv Space Res Planetary protection issues for Mars sample acquisition flight projects. 1911-6 The planned NASA sample acquisition flight missions to Mars pose several interesting planetary protection issues. In addition to the usual forward contamination procedures for the adequate protection of Mars for the sake of future missions, there are reasons to ensure that the sample is not contaminated by terrestrial microbes from the acquisition mission. Recent recommendations by the Space Studies Board (SSB) of the National Research Council (United States), would indicate that the scientific integrity of the sample is a planetary protection concern (SSB, 1997). Also, as a practical matter, a contaminated sample would interfere with the process for its release from quarantine after return for distribution to the interested scientists. These matters are discussed in terms of the first planned acquisition mission. c2001 COSPAR Published by Elsevier Science Ltd. All rights reserved. Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. Barengoltz J B JB eng Journal Article Research Support, U.S. Gov't, Non-P.H.S.

United States Adv Space Res 9878935 7722-84-1 Hydrogen Peroxide S Containment of Biohazards Environmental Microbiology Extraterrestrial Environment Hot Temperature Hydrogen Peroxide Mars Space Flight standards Spacecraft Specimen Handling Sterilization methods United States United States National Aeronautics and Space Administration standards 00027913 NASA Center JPL NASA Discipline Exobiology Barengoltz J B JB JPL 12101218 2002 07 08 2002 08 12 2006 11 15

0021-9258 277 28 2002 Jul 12 J. Biol. Chem. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. 24983-7 The recruitment of FtsZ to the septum and its subsequent interaction with other cell division proteins in a spatially and temporally controlled manner are the keys to bacterial cell division. In the present study, we have tested the hypothesis that FtsZ and FtsW of Mycobacterium tuberculosis could be binding partners. Using gel renaturation, pull-down, and solid-phase assays, we confirm that FtsZ and FtsW interact through their C-terminal tails, which carry extensions absent in their Escherichia coli counterparts. Crucial to these interactions is the cluster of aspartate residues Asp(367) to Asp(370) of FtsZ, which most likely interact with a cluster of positively charged residues in the C-terminal tail of FtsW. Mutations of the aspartate residues 367-370 showed that changing three aspartate residues to alanine resulted in complete loss of interaction. This is the first demonstration of the direct interaction between FtsZ and FtsW. We speculate that this interaction between FtsZ and FtsW could serve to anchor FtsZ to the membrane and link septum formation to peptidoglycan synthesis in M. tuberculosis. The findings assume particular significance in view of the global efforts to explore new targets in M. tuberculosis for chemotherapeutic intervention. Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, India. Datta Pratik P Dasgupta Arunava A Bhakta Sanjib S Basu Joyoti J eng Journal Article Research Support, Non-U.S. Gov't 2002 05 06

United States J Biol Chem 2985121R 0 Bacterial Proteins 0 Cytoskeletal Proteins 0 DNA Primers 0 FtsZ protein, Bacteria 0 Membrane Proteins 125724-13-2 FtsW protein, Bacteria IM Amino Acid Sequence Bacterial Proteins chemistry metabolism Base Sequence Cytoskeletal Proteins DNA Primers Membrane Proteins Molecular Sequence Data Mycobacterium tuberculosis metabolism Protein Binding 12145319 2002 07 29 2002 09 16 2005 11 17

0021-9258 277 31 2002 Aug 2 J. Biol. Chem. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. 28271-9 The regulation of SNARE complex assembly likely plays an important role in governing the specificity as well as the timing of membrane fusion. Here we identify a novel brain-enriched protein, amisyn, with a tomosyn- and VAMP-like coiled-coil-forming domain that binds specifically to syntaxin 1a and syntaxin 4 both in vitro and in vivo, as assessed by co-immunoprecipitation from rat brain. Amisyn is mostly cytosolic, but a fraction co-sediments with membranes. The amisyn coil domain can form SNARE complexes of greater thermostability than can VAMP2 with syntaxin 1a and SNAP-25 in vitro, but it lacks a transmembrane anchor and so cannot act as a v-SNARE in this complex. The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles. We propose that amisyn forms nonfusogenic complexes with syntaxin 1a and SNAP-25, holding them in a conformation ready for VAMP2 to replace it to mediate the membrane fusion event, thereby contributing to the regulation of SNARE complex formation. Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5345, USA. Scales Suzie J SJ Hesser Boris A BA Masuda Esteban S ES Scheller Richard H RH eng GENBANK AF391153 Journal Article 2002 05 24

United States J Biol Chem 2985121R 0 Carrier Proteins 0 Membrane Proteins 0 Nerve Tissue Proteins 0 Qa-SNARE Proteins 0 Recombinant Fusion Proteins 0 SNAP25 protein, human 0 SNARE Proteins 0 STX1A protein, human 0 STXBP6 protein, human 0 Snap25 protein, rat 0 Stx1a protein, rat 0 Synaptosomal-Associated Protein 25 0 Syntaxin 1 0 Vesicular Transport Proteins 51-41-2 Norepinephrine EC 2.5.1.18 Glutathione Transferase IM Amino Acid Sequence Animals Binding Sites Carrier Proteins chemistry genetics physiology Exocytosis Glutathione Transferase genetics Hela Cells Humans Kinetics Membrane Proteins chemistry metabolism physiology Molecular Sequence Data Nerve Tissue Proteins chemistry metabolism Norepinephrine antagonists & inhibitors secretion PC12 Cells Pheochromocytoma Protein Structure, Secondary Qa-SNARE Proteins Rats Recombinant Fusion Proteins metabolism SNARE Proteins Sequence Alignment Sequence Homology, Amino Acid Synaptosomal-Associated Protein 25 Syntaxin 1 Thermodynamics Vesicular Transport Proteins 12159900 2002 08 03 2002 08 22 2007 11 15

0362-4331 2002 Jul 2 Weighing medical ethics for many years to come: a conversation with Harold Shapiro. Interview by Howard Markel. F6 Shapiro Harold H eng Interview Newspaper Article

United States NY Times (Print) 9877126 E Advisory Committees Bioethical Issues Biomedical Research Biotechnology Cloning, Organism Conflict of Interest Embryo Research Embryo, Mammalian cytology Financing, Government Health Priorities Human Experimentation Humans Research Support as Topic Stem Cells United States 103061 VF 2.1 Bioethics and Professional Ethics National Bioethics Advisory Commission Popular Approach/Source KIE Bib: bioethics 12174865 2002 08 13 2002 08 21 2004 11 17

1145-0762 11 2 2000 Jun Physicians' attitudes towards medical ethics issues in Turkey. 57-67 Dept. of Deontology, Faculty of Medicine, University of Ankara, Tip. Fak. Dekanligi, Morfoloji Terleskesi, Anakara, Sihhiye - 06100 Turkey. Pelin S S SS Arda B B eng Journal Article

France J Int Bioethique 9015754 E Abortion, Induced Animal Experimentation Animals Attitude of Health Personnel Bioethical Issues Biomedical Research Complementary Therapies Confidentiality Data Collection Ethics, Medical Ethics, Research Euthanasia Humans Physician-Patient Relations Physicians psychology Prejudice Reproductive Techniques, Assisted Truth Disclosure Turkey 102894 Bioethics and Professional Ethics Empirical Approach Pelin, Serap Sahinoglu; Arda, Berna KIE Bib: bioethics; medical ethics 12192682 2002 08 22 2002 09 09 2006 11 15

0018-9251 35 3 1999 Jul Intelligent control of a planning system for astronaut training. 1055-70 This work intends to design, analyze and solve, from the systems control perspective, a complex, dynamic, and multiconstrained planning system for generating training plans for crew members of the NASA-led International Space Station. Various intelligent planning systems have been developed within the framework of artificial intelligence. These planning systems generally lack a rigorous mathematical formalism to allow a reliable and flexible methodology for their design, modeling, and performance analysis in a dynamical, time-critical, and multiconst