10540283 1999 12 17 1999 12 17 2006 11 15

0950-382X 34 1 1999 Oct Mol. Microbiol. Transcription regulation of the nir gene cluster encoding nitrite reductase of Paracoccus denitrificans involves NNR and NirI, a novel type of membrane protein. 24-36 The nirIX gene cluster of Paracoccus denitrificans is located between the nir and nor gene clusters encoding nitrite and nitric oxide reductases respectively. The NirI sequence corresponds to that of a membrane-bound protein with six transmembrane helices, a large periplasmic domain and cysteine-rich cytoplasmic domains that resemble the binding sites of [4Fe-4S] clusters in many ferredoxin-like proteins. NirX is soluble and apparently located in the periplasm, as judged by the predicted signal sequence. NirI and NirX are homologues of NosR and NosX, proteins involved in regulation of the expression of the nos gene cluster encoding nitrous oxide reductase in Pseudomonas stutzeri and Sinorhizobium meliloti. Analysis of a NirI-deficient mutant strain revealed that NirI is involved in transcription activation of the nir gene cluster in response to oxygen limitation and the presence of N-oxides. The NirX-deficient mutant transiently accumulated nitrite in the growth medium, but it had a final growth yield similar to that of the wild type. Transcription of the nirIX gene cluster itself was controlled by NNR, a member of the family of FNR-like transcriptional activators. An NNR binding sequence is located in the middle of the intergenic region between the nirI and nirS genes with its centre located at position -41.5 relative to the transcription start sites of both genes. Attempts to complement the NirI mutation via cloning of the nirIX gene cluster on a broad-host-range vector were unsuccessful, the ability to express nitrite reductase being restored only when the nirIX gene cluster was reintegrated into the chromosome of the NirI-deficient mutant via homologous recombination in such a way that the wild-type nirI gene was present directly upstream of the nir operon. Department of Molecular Cell Physiology, Faculty of Biology, BioCentrum Amsterdam, Vrije Universiteit, De Boelelaan 1087, NL-1081 HV Amsterdam, The Netherlands. Saunders N F NF Houben E N EN Koefoed S S de Weert S S Reijnders W N WN Westerhoff H V HV De Boer A P AP Van Spanning R J RJ eng GENBANK AF005358 U47133 U94899 PDB P33943 Journal Article Research Support, Non-U.S. Gov't

ENGLAND Mol Microbiol 8712028 0950-382X 0 Bacterial Proteins 0 DNA-Binding Proteins 0 Membrane Proteins 0 NNR protein, Paracoccus denitrificans 0 NirI protein, Paracoccus denitrificans 0 NirX protein, Paracoccus denitrificans 0 Transcription Factors EC 1.7.- Nitrite Reductases IM Amino Acid Sequence Bacterial Proteins Base Sequence DNA-Binding Proteins Gene Expression Regulation, Bacterial Genetic Complementation Test Membrane Proteins chemistry genetics metabolism Molecular Sequence Data Multigene Family Mutation Nitrite Reductases genetics metabolism Paracoccus denitrificans genetics metabolism Protein Structure, Secondary Sequence Homology, Amino Acid Transcription Factors genetics metabolism Transcription, Genetic 10612833 2000 01 20 2000 01 20 2009 11 19

1098-1004 15 1 2000 Jan Hum. Mutat. Erratum: analysis of DNA elements that modulate myosin VIIa expression in humans. 114-5 Usher syndromeIb (USH1B), an autosomal recessive disorder caused by mutations in myosin VIIa (MYO7A), is characterized by congenital profound hearing loss, vestibular abnormalities and retinitis pigmentosa. Promoter elements in the 5 kb upstream of the translation start were identified using adult retinal pigment epithelium cells (ARPE-19) as a model system. A 160 bp minimal promoter within the first intron was active in ARPE-19 cells, but not in HeLa cells that do not express MYO7A. A 100 bp sequence, 5' of the first exon, and repeated with 90% homology within the first intron, appeared to modulate expression in both cell lines. Segments containing these elements were screened by heteroduplex analysis. No heteroduplexes were detected in the minimal promoter, suggesting that this sequence is conserved. A -2568 A>T transversion in the 5' 100 bp repeat, eliminating a CCAAT element, was found only in USH1B patients. However, in all 5 families, -2568 A>T was in cis with the same missense mutation in the myosin VIIa tail (Arg1240Gln), and 4 of the 5 families were Dutch. These observations suggest either 1) linkage disequilibrium or 2)that a combination of a promoter mutation with a less active myosin VIIa protein results in USH1B. Copyright 2000 Wiley-Liss, Inc. Center for Hereditary Communication Disorders, Boys Town National Research Hospital Omaha, NE, USA. ortend@boystown.org Orten D J DJ Weston M D MD Kelley P M PM Cremers C W CW Wagenaar M M Jacobson S G SG Kimberling W J WJ eng DC00677 DC NIDCD NIH HHS United States DC00982 DC NIDCD NIH HHS United States DC03351 DC NIDCD NIH HHS United States Corrected and Republished Article Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

UNITED STATES Hum Mutat 9215429 1059-7794 EC 3.6.1.33 myosin VIIa EC 3.6.4.1 Myosins EC 3.6.4.2 Dyneins IM Hum Mutat. 1999 Oct;14(4):354 10502787 Amino Acid Substitution Cell Line Dyneins Gene Expression Regulation HeLa Cells Hearing Loss, Sensorineural genetics metabolism Humans Linkage Disequilibrium Mutation, Missense Myosins biosynthesis genetics Pedigree Pigment Epithelium of Eye metabolism Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Promoter Regions, Genetic Retinitis Pigmentosa genetics metabolism Syndrome Vestibular Diseases genetics metabolism 10737756 2000 04 13 2000 04 13 2004 11 17

0022-2623 43 6 2000 Mar 23 J. Med. Chem. Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs. 1234-41 The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the presence of N-methyl-D-glucamine afforded 2-(S)-(1-(R)-(3, 5-bis(trifluoromethyl)phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(5-(2- phosphoryl-3-oxo-4H,-1,2,4-triazolo)methylmorpholine, bis(N-methyl-D-glucamine) salt, 11. Incubation of 11 in rat, dog, and human plasma and in human hepatic subcellular fractions in vitro indicated that conversion to 2 would be expected to occur in vivo most readily in humans during hepatic circulation. Conversion of 11 to 2 occurred rapidly in vivo in the rat and dog with the levels of 11 being undetectable within 5 min after 1 and 8 mg/kg doses iv in the rat and within 15 min after 0.5, 2, and 32 mg/kg doses iv in the dog. Compound 11 has a 10-fold lower affinity for the human NK-1 receptor as compared to 2, but it is functionally equivalent to 2 in preclinical models of NK-1-mediated inflammation in the guinea pig and cisplatin-induced emesis in the ferret, indicating that 11 acts as a prodrug of 2. Based in part on these data, 11 was identified as a novel, water-soluble prodrug of the clinical candidate 2 suitable for intravenous administration in humans. Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Merck, Sharp & Dohme, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K. jeffrey_hale@merck.com Hale J J JJ Mills S G SG MacCoss M M Dorn C P CP Finke P E PE Budhu R J RJ Reamer R A RA Huskey S E SE Luffer-Atlas D D Dean B J BJ McGowan E M EM Feeney W P WP Chiu S H SH Cascieri M A MA Chicchi G G GG Kurtz M M MM Sadowski S S Ber E E Tattersall F D FD Rupniak N M NM Williams A R AR Rycroft W W Hargreaves R R Metzger J M JM MacIntyre D E DE eng Journal Article

UNITED STATES J Med Chem 9716531 0022-2623 0 2-(1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluoro)phenyl-4-(5-(2-phosphoryl-3-oxo-4H,-1,2,4-triazolo))methylmorpholine, bis(N-methylglucamine) salt 0 Acetals 0 Anti-Inflammatory Agents, Non-Steroidal 0 Antiemetics 0 Antineoplastic Agents 0 L 754030 0 Morpholines 0 Prodrugs 0 Receptors, Neurokinin-1 15663-27-1 Cisplatin 7732-18-5 Water IM Acetals chemical synthesis chemistry metabolism pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal chemical synthesis chemistry metabolism pharmacology Antiemetics chemical synthesis chemistry metabolism pharmacology Antineoplastic Agents Cisplatin Dogs Drug Evaluation, Preclinical Ferrets Guinea Pigs Humans Morpholines chemical synthesis chemistry metabolism pharmacology Prodrugs chemical synthesis chemistry metabolism pharmacology Rats Receptors, Neurokinin-1 antagonists & inhibitors Solubility Stereoisomerism Structure-Activity Relationship Vomiting chemically induced drug therapy Water 10854512 2000 06 29 2000 06 29 2004 11 17

1432-2218 14 1 2000 Jan Surg Endosc Inflammatory fibroid polyp of the duodenum. 86 Duodenal inflammatory fibroid polyps (IFP) are extemely rare lesions indistinguishable from submucosal tumors by endoscopic inspection alone. Like gastric inflammatory fibroid polyps, they can be managed by endoscopic polypectomy or mucosectomy. However, preoperative diagnosis of this benign lesion is difficult. Here we present a case of duodenal IFP causing gastrointestinal bleeding that was evaluated by endoscopic ultrasound before surgical removal. On endosonography, the duodenal IFP appeared as a coarsely heterogeneous isoechoic and hypoechoic mass circumscribed by a distinct margin and arising from the third layer of the duodenal wall. The endosonographic appearance of this lesion was in marked contrast to that previously reported for gastric IFPs, which have tended to appear as hypoechoic homogeneous lesions with indistinct margins. Endosonographic evaluation of suspected IFPs before endoscopic or surgical treatment is useful. However, the endosonographic appearances of duodenal and gastric IFPs may be significantly different, possibly because of differences in the makeup of the duodenal and gastric walls. Division of Gastroenterology, ChangHua Christian Medical Center, ChangHua, Taiwan. Soon M S MS Lin O S OS eng Case Reports Journal Article 1999 11 25

UNITED STATES Surg Endosc 8806653 0930-2794 IM Duodenal Neoplasms complications pathology surgery Duodenitis etiology pathology surgery Endoscopy, Gastrointestinal Endosonography Female Fibroma pathology surgery Gastric Mucosa pathology Gastrointestinal Hemorrhage etiology pathology surgery Humans Intestinal Polyps complications pathology surgery Middle Aged 10972993 2000 09 26 2000 09 26 2008 11 21

0899-1987 28 4 2000 Aug Mol. Carcinog. Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines. 236-46 Germline mutations of BRCA1 and BRCA2 predispose to hereditary breast, ovarian, and possibly prostate cancer, yet structural mutations in these genes are infrequent in sporadic cancer cases. To better define the involvement of these genes in sporadic cancers, we characterized expression levels of BRCA1 and BRCA2 transcripts in cancer cell lines derived from neoplasms of the ovary, prostate, and breast and compared them with those expressed in primary cultures of normal epithelial cells established from these organs. We observed upregulation of BRCA1 and/or BRCA2 expression in six of seven ovarian cancer cell lines (OVCA420, OVCA429, OVCA432, ALST, DOV13, and SKOV3) when compared with levels found in normal ovary surface epithelial cells. Furthermore, five cancerous or immortalized prostatic epithelial cell lines (BPH-1, TSU-Pr1, LNCaP, PC-3, and DU145) also expressed higher levels of BRCA1 and/or BRCA2 mRNA than did primary cultures of normal prostatic epithelial cells. In contrast, only the estrogen receptor-positive MCF-7 cell line overexpressed these messages, whereas the estrogen receptor-negative breast cancer cell lines Hs578T, MDA-MB-231, and MDA-MB-468 showed no change in expression levels when compared with normal breast epithelial cells. In addition, expanding on our recent identification of a novel BRCA2 transcript variant carrying an in-frame exon 12 deletion (BRCA2 delta 12), we report increased expression of this variant in several ovarian, prostate, and mammary cancer cell lines (OVCA420, OVCA433, ALST, DOV13, SKOV3, TSU-Pr1, DU145, and MDA-MB-468). Most notably, high levels of BRCA2 delta 12 mRNA were detected in an estrogen receptor-positive breast cancer cell line, MCF-7, and in an androgen-independent prostate cancer cell line, DU-145. Interestingly, the wild-type BRCA2 transcript was barely detectable in DU145, which could be used as a model system for future investigations on BRCA2 delta 12 function. Taken together, our data suggest disruption of BRCA1 and/or BRCA2 gene expression in certain epithelial cancer cell lines of the ovary, prostate, and breast. Because wild-type BRCA1 and BRCA2 gene products increase during cell-cycle progression and are believed to exert growth-inhibitory action, enhanced expression of these genes in cancer cells may represent a negative feedback mechanism for curbing proliferation in fast-growing cells. At present, the functionality of BRCA2 delta 12 remains elusive. Copyright 2000 Wiley-Liss, Inc. Department of Biology, Tufts University, Medford, Massachusetts, USA. Rauh-Adelmann C C Lau K M KM Sabeti N N Long J P JP Mok S C SC Ho S M SM eng C69453 PHS HHS United States CA15576 CA NCI NIH HHS United States CA62269 CA NCI NIH HHS United States Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

UNITED STATES Mol Carcinog 8811105 0899-1987 0 BRCA1 Protein 0 BRCA2 Protein 0 Neoplasm Proteins 0 RNA, Messenger 0 Transcription Factors IM BRCA1 Protein genetics BRCA2 Protein Breast metabolism Breast Neoplasms genetics Cell Line Epithelial Cells metabolism Exons Female Gene Expression Regulation, Neoplastic Genes, BRCA1 Genetic Variation Humans Male Neoplasm Proteins genetics Ovarian Neoplasms genetics Prostatic Neoplasms genetics RNA, Messenger genetics Sequence Deletion Transcription Factors genetics Transcription, Genetic Tumor Cells, Cultured 11025314 2001 01 05 2001 01 05 2006 11 15

0108-2701 56 ( Pt 10) 2000 Oct Acta Crystallogr C Multicentre hydrogen bonds in a 2:1 arylsulfonylimidazolone hydrochloride salt. 1247-50 The title compound, (S)-(+)-4-[5-(2-oxo-4, 5-dihydroimidazol-1-ylsulfonyl)indolin-1 -ylcarbonyl ]anilinium chloride (S)-(+)-1-[1-(4-aminobenzoyl)indoline-5- sulfonyl]-4-phenyl-4, 5-dihydroimidazol-2-one, C(24)H(23)N(4)O(4)S(+).Cl(-). C(24)H(22)N(4)O(4)S, crystallizes in space group C2 from a CH(3)OH/CH(2)Cl(2) solution. In the crystal structure, there are two different conformers with their terminal C(6) aromatic rings mutually oriented at angles of 67.69 (14) and 61.16 (15) degrees. The distances of the terminal N atoms (of the two conformers) from the chloride ion are 3.110 (4) and 3.502 (4) A. There are eight distinct hydrogen bonds, i.e. four N-H...Cl, three N-H...O and one N-H...N, with one N-H group involved in a bifurcated hydrogen bond with two acceptors sharing the H atom. C-H...O contacts assist in the overall hydrogen-bonding process. College of Pharmacy, Chungnam National University, Taejeon 305-764, Korea. parki@cnu.ac.kr. Park K L KL Moon B G BG Jung S H SH Kim J G JG Suh I H IH eng Journal Article Research Support, Non-U.S. Gov't

DENMARK Acta Crystallogr C 8305826 0108-2701 0 1-(1-(4-aminobenzoyl)indoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazol-2-one 0 Antineoplastic Agents 0 Imidazoles 0 Sulfones IM Antineoplastic Agents chemistry Crystallography, X-Ray Hydrogen Bonding Imidazoles chemistry Models, Molecular Molecular Conformation Stereoisomerism Sulfones chemistry 11056631 2000 12 01

0031-9007 85 19 2000 Nov 6 Phys. Rev. Lett. Dislocated epitaxial islands. 4088-91 Dislocation networks observed in CoSi (2) islands grown epitaxially on Si are compared with the results of dislocation-dynamics calculations. The calculations make use of the fact that image forces play a relatively minor role compared to line tension forces and dislocation-dislocation interactions. Remarkable agreement is achieved, demonstrating that this approach can be applied more generally to study dislocations in other mesostructures. IBM Watson Research Center, P.O. Box 218, Yorktown Heights, New York 10598, USA. Liu X H XH Ross F M FM Schwarz K W KW eng Journal Article

UNITED STATES Phys Rev Lett 0401141 0031-9007 IM 11034741 2001 01 26 2001 08 02 2007 11 15

1469-493X 4 2000 Cochrane Database Syst Rev Parent-training programmes for improving maternal psychosocial health. CD002020 The prevalence of mental health problems in women is 1:3 and such problems tend to be persistent. There is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for the psychological health of the child. It is now thought that parenting programmes may have an important role to play in the improvement of maternal psychosocial health. The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression and self-esteem. A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR). Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health. A systematic critical appraisal of all included studies was undertaken using the Journal of the American Medical Association (JAMA) published criteria. The data were summarised using effect sizes but were not combined in a meta-analysis due to the small number of studies within each group and the presence of significant heterogeneity. A total of 22 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. These 17 studies reported on a total of 59 outcomes including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. Approximately 22% of the outcomes measured suggested significant differences favouring the intervention group. A further 40% showed differences favouring the intervention group but which failed to achieve conventional levels of statistical significance, in some cases due to the small numbers that were used. Approximately 38% of outcomes suggested no evidence of effectiveness. It is suggested that parenting programmes can make a significant contribution to the improvement of psychosocial health in mothers. While the critical appraisal suggests some variability in the quality of the included studies, it is concluded that there is sufficient evidence to support their use with diverse groups of parents. However, it is also suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required. Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Oxford, UK, OX3 7LF. esther.coren@dphpc.ox.ac.uk Barlow J J Coren E E eng Journal Article Review

England Cochrane Database Syst Rev 100909747 1361-6137 IM Cochrane Database Syst Rev. 2001;(2):CD002020 11406024 Anxiety therapy Depression therapy Female Humans Maternal Behavior psychology Mother-Child Relations Parenting Program Evaluation Randomized Controlled Trials as Topic Self Concept 99 11237011 2001 03 09 2001 03 22 2006 11 15

0028-0836 409 6822 2001 Feb 15 Nature Initial sequencing and analysis of the human genome. 860-921 The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence. Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA. lander@genome.wi.mit.edu Lander E S ES Linton L M LM Birren B B Nusbaum C C Zody M C MC Baldwin J J Devon K K Dewar K K Doyle M M FitzHugh W W Funke R R Gage D D Harris K K Heaford A A Howland J J Kann L L Lehoczky J J LeVine R R McEwan P P McKernan K K Meldrim J J Mesirov J P JP Miranda C C Morris W W Naylor J J Raymond C C Rosetti M M Santos R R Sheridan A A Sougnez C C Stange-Thomann N N Stojanovic N N Subramanian A A Wyman D D Rogers J J Sulston J J Ainscough R R Beck S S Bentley D D Burton J J Clee C C Carter N N Coulson A A Deadman R R Deloukas P P Dunham A A Dunham I I Durbin R R French L L Grafham D D Gregory S S Hubbard T T Humphray S S Hunt A A Jones M M Lloyd C C McMurray A A Matthews L L Mercer S S Milne S S Mullikin J C JC Mungall A A Plumb R R Ross M M Shownkeen R R Sims S S Waterston R H RH Wilson R K RK Hillier L W LW McPherson J D JD Marra M A MA Mardis E R ER Fulton L A LA Chinwalla A T AT Pepin K H KH Gish W R WR Chissoe S L SL Wendl M C MC Delehaunty K D KD Miner T L TL Delehaunty A A Kramer J B JB Cook L L LL Fulton R S RS Johnson D L DL Minx P J PJ Clifton S W SW Hawkins T T Branscomb E E Predki P P Richardson P P Wenning S S Slezak T T Doggett N N Cheng J F JF Olsen A A Lucas S S Elkin C C Uberbacher E E Frazier M M Gibbs R A RA Muzny D M DM Scherer S E SE Bouck J B JB Sodergren E J EJ Worley K C KC Rives C M CM Gorrell J H JH Metzker M L ML Naylor S L SL Kucherlapati R S RS Nelson D L DL Weinstock G M GM Sakaki Y Y Fujiyama A A Hattori M M Yada T T Toyoda A A Itoh T T Kawagoe C C Watanabe H H Totoki Y Y Taylor T T Weissenbach J J Heilig R R Saurin W W Artiguenave F F Brottier P P Bruls T T Pelletier E E Robert C C Wincker P P Smith D R DR Doucette-Stamm L L Rubenfield M M Weinstock K K Lee H M HM Dubois J J Rosenthal A A Platzer M M Nyakatura G G Taudien S S Rump A A Yang H H Yu J J Wang J J Huang G G Gu J J Hood L L Rowen L L Madan A A Qin S S Davis R W RW Federspiel N A NA Abola A P AP Proctor M J MJ Myers R M RM Schmutz J J Dickson M M Grimwood J J Cox D R DR Olson M V MV Kaul R R Raymond C C Shimizu N N Kawasaki K K Minoshima S S Evans G A GA Athanasiou M M Schultz R R Roe B A BA Chen F F Pan H H Ramser J J Lehrach H H Reinhardt R R McCombie W R WR de la Bastide M M Dedhia N N Blöcker H H Hornischer K K Nordsiek G G Agarwala R R Aravind L L Bailey J A JA Bateman A A Batzoglou S S Birney E E Bork P P Brown D G DG Burge C B CB Cerutti L L Chen H C HC Church D D Clamp M M Copley R R RR Doerks T T Eddy S R SR Eichler E E EE Furey T S TS Galagan J J Gilbert J G JG Harmon C C Hayashizaki Y Y Haussler D D Hermjakob H H Hokamp K K Jang W W Johnson L S LS Jones T A TA Kasif S S Kaspryzk A A Kennedy S S Kent W J WJ Kitts P P Koonin E V EV Korf I I Kulp D D Lancet D D Lowe T M TM McLysaght A A Mikkelsen T T Moran J V JV Mulder N N Pollara V J VJ Ponting C P CP Schuler G G Schultz J J Slater G G Smit A F AF Stupka E E Szustakowski J J Thierry-Mieg D D Thierry-Mieg J J Wagner L L Wallis J J Wheeler R R Williams A A Wolf Y I YI Wolfe K H KH Yang S P SP Yeh R F RF Collins F F Guyer M S MS Peterson J J Felsenfeld A A Wetterstrand K A KA Patrinos A A Morgan M J MJ de Jong P P Catanese J J JJ Osoegawa K K Shizuya H H Choi S S Chen Y J YJ Szustakowki J J International Human Genome Sequencing Consortium eng Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

England Nature 0410462 0028-0836 0 DNA Transposable Elements 0 Proteins 0 Proteome 63231-63-0 RNA IM Nature. 2001 Oct 18;413(6857):660 11606985 Nature. 2001 Feb 15;409(6822):822-3 11236997 Nature. 2001 Feb 15;409(6822):818-20 11236994 Nature. 2001 Feb 15;409(6822):820-1 11236995 Nature. 2001 Feb 15;409(6822):814-6 11236992 Nature 2001 Jun 7;411(6838):720 Szustakowki, J [corrected to Szustakowski, J] Nature 2001 Aug 2;412(6846):565 Animals Chromosome Mapping Conserved Sequence CpG Islands DNA Transposable Elements Databases, Factual Drug Industry Evolution, Molecular Forecasting GC Rich Sequence Gene Duplication Genes Genetic Diseases, Inborn Genetics, Medical Genome, Human Human Genome Project Humans Mutation Private Sector Proteins genetics Proteome Public Sector RNA genetics Repetitive Sequences, Nucleic Acid Sequence Analysis, DNA methods Species Specificity 11243089 2001 03 12 2001 05 17 2006 11 15

0019-557X 43 1 1999 Jan-Mar Indian J Public Health Nutritional status of pavement dweller children of Calcutta City. 49-54 Pavement dwelling is likely to aggravate malnutrition among its residents due to extreme poverty, lack of dwelling and access to food and their exposure to polluted environment. Paucity of information about nutritional status of street children compared to that among urban slum dwellers, squatters or rural/tribal population is quite evident. The present study revealed the magnitude of Protein Energy Malnutrition (PEM) and few associated factors among a sample of 435 underfives belonging to pavement dweller families and selected randomly from clusters of such families, from each of the five geographical sectors of Calcutta city. Overall prevalence of PEM was found almost similar (about 70%) to that among other 'urban poor' children viz. slum dwellers etc., but about 16% of them were found severely undernourished (Grade III & V of IAP classification of PEM). About 35% and 70% of street dweller children had wasting and stunting respectively. Severe PEM (Grade III & IV) was more prevalent among 12-23 months old, girl child, those belonged to illiterate parents and housewife mothers rather than wage earners. It also did increase with increase of birth rate of decrease of birth interval. Department of Community Medicine, Medical College, Calcutta. Ray S K SK Mishra R R Biswas R R Kumar S S Halder A A Chatterjee T T eng Journal Article Research Support, Non-U.S. Gov't

India Indian J Public Health 0400673 0019-557X IM J Child, Preschool Cluster Analysis Cross-Sectional Studies Educational Status Female Humans India epidemiology Infant Male Nutritional Status Poverty Prejudice Prevalence Protein-Energy Malnutrition epidemiology 143717 00288124 This document presents a cross-sectional survey concerning the magnitude of protein energy malnutrition (PEM) and its associated factors among 435 under-5 pavement-dwelling children in Calcutta. Results revealed that 69.43% were undernourished and that 16% of them were suffering from severe malnutrition (grade III and IV of the Indian Academy of Pediatrics criteria for PEM). The 24-35 month age group had the highest prevalence of malnutrition (82.93%) followed by the 36-47 and 12-23 month age groups with prevalences of 76.19% and 74.03%, respectively. Prevalence of severe grade malnutrition was noted to be three times higher in females (24.76%) than males (8.45%), and among families it increased in direct proportion to birth rate and inverse proportion to birth interval. Moreover, children of illiterate parents and nonworking mothers had a higher incidence of severe PEM. Simple measures such as exclusive breast-feeding and timely complementary feeding as well as measures directed toward birth spacing and limiting family size should be implemented to solve the problem of malnutrition. Age Factors Asia Child Child Nutrition Demographic Factors Developing Countries Diseases Geographic Factors Health Homeless Persons India Malnutrition Nutrition Nutrition Disorders Population Population Characteristics Research Methodology Research Report Residence Characteristics Sampling Studies Southern Asia Spatial Distribution Studies Surveys Urban Population Youth TJ: INDIAN JOURNAL OF PUBLIC HEALTH. 11238657 2001 03 12 2001 05 17 2006 11 15

0022-1767 166 6 2001 Mar 15 J. Immunol. Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. 4083-91 Increasing evidence suggests that a continuous release of histamine from mast cells occurs in the airways of asthmatic patients and that histamine may modulate functions of other inflammatory cells such as macrophages. In the present study histamine (10(-9)-10(-6) M) increased in a concentration-dependent fashion the basal release of beta-glucuronidase (EC(50) = 8.2 +/- 3.5 x 10(-9) M) and IL-6 (EC(50) = 9.3 +/- 2.9 x 10(-8) M) from human lung macrophages. Enhancement of beta-glucuronidase release induced by histamine was evident after 30 min and peaked at 90 min, whereas that of IL-6 required 2-6 h of incubation. These effects were reproduced by the H(1) agonist (6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptane carboxamide but not by the H(2) agonist dimaprit. Furthermore, histamine induced a concentration-dependent increase of intracellular Ca(2+) concentrations ([Ca(2+)](i)) that followed three types of response, one characterized by a rapid increase, a second in which [Ca(2+)](i) displays a slow but progressive increase, and a third characterized by an oscillatory pattern. Histamine-induced beta-glucuronidase and IL-6 release and [Ca(2+)](i) elevation were inhibited by the selective H(1) antagonist fexofenadine (10(-7)-10(-4) M), but not by the H(2) antagonist ranitidine. Inhibition of histamine-induced beta-glucuronidase and IL-6 release by fexofenadine was concentration dependent and displayed the characteristics of a competitive antagonism (K(d) = 89 nM). These data demonstrate that histamine induces exocytosis and IL-6 production from human macrophages by activating H(1) receptor and by increasing [Ca(2+)](i) and they suggest that histamine may play a relevant role in the long-term sustainment of allergic inflammation in the airways. Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy. triggian@unina.it Triggiani M M Gentile M M Secondo A A Granata F F Oriente A A Taglialatela M M Annunziato L L Marone G G eng Journal Article Research Support, Non-U.S. Gov't

United States J Immunol 2985117R 0022-1767 0 Histamine Agonists 0 Histamine H1 Antagonists 0 Histamine H2 Antagonists 0 Interleukin-6 0 RNA, Messenger 0 Receptors, Histamine H1 0 Toluidines 103827-15-2 6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide 51-45-6 Histamine 65119-89-3 Dimaprit 7440-70-2 Calcium EC 3.2.1.31 Glucuronidase AIM IM Calcium metabolism physiology Cytosol metabolism Dimaprit pharmacology Dose-Response Relationship, Immunologic Exocytosis immunology Glucuronidase secretion Histamine analogs & derivatives pharmacology physiology Histamine Agonists pharmacology Histamine H1 Antagonists pharmacology Histamine H2 Antagonists pharmacology Humans Interleukin-6 biosynthesis genetics secretion Lung cytology enzymology immunology metabolism Macrophages, Alveolar enzymology immunology metabolism secretion RNA, Messenger biosynthesis Receptors, Histamine H1 metabolism Toluidines pharmacology Up-Regulation immunology 11279676 2001 03 30 2001 12 07 2007 11 15

1469-493X 1 2001 Cochrane Database Syst Rev Elective versus selective caesarean section for delivery of the small baby. CD000078 Elective caesarean delivery for women in preterm labour might reduce the chances of fetal or neonatal death, but it might also increase the risk of maternal morbidity. To assess the effects of a policy of elective caesarean delivery versus selective caesarean delivery for women in preterm labour. The Cochrane Pregnancy and Childbirth Group trials register was searched. Date of last search: September 2000. Randomised trials comparing a policy of elective caesarean delivery versus expectant management with recourse to caesarean section. One reviewer assessed eligibility and trial quality, and both contributed to the update. Six studies involving 122 women were included. All trials reported recruiting difficulties. No significant differences between elective and selective policies for caesarean delivery were found for fetal, neonatal or maternal outcomes. There is not enough evidence to evaluate the use of a policy for elective caesarean delivery for small babies. Randomised trials in this area are likely to continue to experience recruitment problems. However, it still may be possible to investigate elective caesarean delivery in preterm babies with cephalic presentations. Health Services Research Unit, The Polwarth Building, Foresterhill, Aberdeen, UK, AB9 2ZD. a.grant@abdn.ac.uk Grant A A Glazener C M CM eng Journal Article Review

England Cochrane Database Syst Rev 100909747 1361-6137 IM Cochrane Database Syst Rev. 2001;(2):CD000078 11405950 Cochrane Database Syst Rev. 2000;(2):CD000078 10796117 Cesarean Section Female Humans Infant, Newborn Infant, Premature Obstetric Labor, Premature Pregnancy Randomized Controlled Trials as Topic Surgical Procedures, Elective 21 11406024 2001 06 14 2002 02 28 2007 11 15

1469-493X 2 2001 Cochrane Database Syst Rev Parent-training programmes for improving maternal psychosocial health. CD002020 Mental health problems are common, and there is evidence from a range of studies to suggest that a number of factors relating to maternal psychosocial health can have a significant effect on the mother-infant relationship, and that this can have consequences for both the short and long-term psychological health of the child. The use of parenting programmes is increasing in the UK and evidence of their effectiveness in improving outcomes for mothers is now required. The objective of this review is to address whether group-based parenting programmes are effective in improving maternal psychosocial health including anxiety, depression, and self-esteem. A range of biomedical, social science, educational and general reference electronic databases were searched including MEDLINE, EMBASE CINAHL, PsychLIT, ERIC, ASSIA, Sociofile and the Social Science Citation Index. Other sources of information included the Cochrane Library (SPECTR, CENTRAL), and the National Research Register (NRR). Only randomised controlled trials were included in which participants had been randomly allocated to an experimental and a control group, the latter being either a waiting-list, no-treatment or a placebo control group. Studies had to include at least one group-based parenting programme, and one standardised instrument measuring maternal psychosocial health. A systematic critical appraisal of all included studies was undertaken using a modified version of the Journal of the American Medical Association (JAMA) published criteria. The treatment effect for each outcome in each study was standardised by dividing the mean difference in post-intervention scores for the intervention and treatment group, by the pooled standard deviation, to produce an effect size. Where appropriate the results were then combined in a meta-analysis using a fixed-effect model, and 95% confidence intervals were used to assess the significance of the findings. A total of 23 studies were included in the review but only 17 provided sufficient data to calculate effect sizes. The 17 studies provided a total of 59 assessments of outcome on a range of aspects of psychosocial functioning including depression, anxiety, stress, self-esteem, social competence, social support, guilt, mood, automatic thoughts, dyadic adjustment, psychiatric morbidity, irrationality, anger and aggression, mood, attitude, personality, and beliefs. There was only sufficient data, however, on five outcomes (depression; anxiety/stress; self-esteem; social support; and relationship with spouse/marital adjustment) to combine the results in a meta-analysis. The meta-analyses show statistically significant results favouring the intervention group as regards depression; anxiety/stress; self-esteem; and relationship with spouse/marital adjustment. The meta-analysis of the social support data, however, showed no evidence of effectiveness. These results suggest that parenting programmes, irrespective of the type (or content) of programme, can be effective in improving important aspects of maternal psycho-social functioning. Of the data summarising the effectiveness of the different types of parenting programmes, which it was not possible to combine in a meta-analysis, approximately 22% of the outcomes measured, showed significant differences between the intervention group and the control group. A further 40% showed medium to large non-significant differences favouring the intervention group. Approximately one-third of outcomes showed small non-significant differences or no evidence of effectiveness. A meta-analysis of the follow-up data on three outcomes was also conducted - depression, self-esteem and relationship with spouse/marital adjustment. The results show that there was a continued improvement in self-esteem, depression and marital adjustment at follow-up, although the latter two findings were not statistically significant. It is suggested that parenting programmes can make a significant contribution to short-term psychosocial health in mothers, and that the limited follow-up data available suggest that these are maintained over time. However, the overall paucity of long-term follow-up data points to the need for further evidence concerning the long-term effectiveness of parenting programmes on maternal mental health. Furthermore, it is suggested that some caution should be exercised before the results are generalised to parents irrespective of the level of pathology present, and that further research is still required. Health Services Research Unit, University of Oxford, Institute of Health Sciences, Old Road, Headington, Oxford, UK, OX3 7LF. esther.coren@public-health.oxford.ac.uk Barlow J J Coren E E eng Journal Article Review

England Cochrane Database Syst Rev 100909747 1361-6137 IM Cochrane Database Syst Rev. 2004;(1):CD002020 14973981 Cochrane Database Syst Rev. 2000;(4):CD002020 11034741 Anxiety therapy Depression therapy Female Humans Maternal Behavior psychology Maternal Welfare Mother-Child Relations Parenting Program Evaluation Randomized Controlled Trials as Topic Self Concept 100 11428848 2001 06 28 2001 09 27 2007 11 15

0195-668X 22 13 2001 Jul Eur. Heart J. Indications for implantable cardioverter defibrillator (ICD) therapy. Study Group on Guidelines on ICDs of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing of the European Society of Cardiology. 1074-81 Heart Lung Center Utrecht, University Medical Center, The Netherlands. Hauer R N RN Aliot E E Block M M Capucci A A Lüderitz B B Santini M M Vardas P E PE European Society of Cardiology. Working Group on Arrhythmias and Working Group on Cardiac Pacing eng Guideline Journal Article Practice Guideline

England Eur Heart J 8006263 0195-668X IM Arrhythmias, Cardiac etiology therapy Arrhythmogenic Right Ventricular Dysplasia therapy Cardiomyopathy, Dilated therapy Cardiomyopathy, Hypertrophic therapy Coronary Disease therapy Death, Sudden, Cardiac prevention & control Defibrillators, Implantable Heart Valve Diseases therapy Humans Long QT Syndrome therapy Ventricular Fibrillation therapy 11441930 2001 07 09 2001 07 19 2009 05 12

0284-186X 40 2-3 2001 Acta Oncol Assessment of quality of life during chemotherapy. 175-84 Increasingly more aggressive chemotherapy together with expected small differences between treatments with respect to objective endpoints has heightened awareness about the importance of addressing how patients experience and value the impact that treatment has had on their overall life situation. Assessment of a patient's quality of life (QoL) is now conceptually viewed as an important complement to traditional objective evaluation measures. It was therefore considered important to review the basis for the assessment of this endpoint when The Swedish Council of Technology Assessment in Health Care (SBU) performed a systematic overview of chemotherapy effects in several tumour types. The group came to the following conclusions: QoL assessments, mostly by patient self-reporting in questionnaires, have come increasingly into use during the past decade. A number of general, cancer-specific and cancer diagnosis-specific instruments have been developed. There is at present little need for development of new cancer instruments, although specific treatment modalities and tumour types may need new additional modules. A predefined hypothesis should determine the instrument to be used. Since the selection of a QoL instrument in a specific study influences both the results and the conclusions, it is essential to carefully select the instrument or instruments that have the greatest likelihood of identifying relevant differences between treatment alternatives. Interpretation of QoL data is more difficult than interpretation of objective endpoints such as survival time, objective response rates or toxicity. Despite these difficulties, QoL analyses have provided new insights into the advantages and disadvantages of various treatments not provided by traditional end-points. Some palliative treatments seemingly increase patients' QoL despite side-effects or the lack of, or marginal, increases in survival. When using potentially curative chemotherapy, it is not a matter of when the treatment should be started, but rather when it should be concluded. When using less active chemotherapy, the expected small therapeutic gains must be weighed against the QoL costs of using the therapy: does the toxicity and/or the inconvenience of the proposed treatment justify the expected gain? When it is found that the strain on the patient is greater than the effects of the cancer, treatment must be discontinued. It is not possible to determine whether or not the advantages of palliative chemotherapy are worth their costs without knowledge about patients' personal values regarding the influence on factors of relevance for QoL. The mostly used QoL questionnaires do not consider individual preferences, which therefore need to be addressed in the dialogue with the patient. QoL assessment is clearly in need of further methodological improvement before this endpoint can be regarded as fully established with respect to ability to provide unequivocally useful data in clinical trials. The multitude of questionnaires, missing data, lack of pre-study hypotheses of relevant differences between treatments and data multiplicity giving a risk for chance findings are examples of serious methodological problems. Patient response-shifts over time further complicate the interpretation of the data. Thus, QoL data, also from seemingly well-performed clinical trials, have to be interpreted cautiously. The international development during recent years has aimed at creating increased standardization of QoL measures. This has created greater possibilities to compare results from different trials. Hopefully, this also implies that it will be possible to draw firmer conclusions from QoL measurements in recently completed or ongoing trials than has been the case previously. QoL assessments are resource demanding even when short standardized questionnaires are used. Since cancer patients also generally give priority to anticancer effects over toxicity and convenience, QoL assessments in clinical trials are motivated mainly in study settings comparing treatments without expected major differences of outcome in objective endpoints. Department of Oncology, University Hospital, Lund, Sweden. Gunnars B B Nygren P P Glimelius B B SBU-group. Swedish Council of Technology Assessment in Health Care eng Journal Article Review

Norway Acta Oncol 8709065 0284-186X 0 Antineoplastic Agents IM Antineoplastic Agents adverse effects therapeutic use Endpoint Determination Humans Neoplasms drug therapy Outcome Assessment (Health Care) Palliative Care Patient Satisfaction Quality of Life Questionnaires 112 11442735 2001 07 09 2001 10 04 2006 11 15

0303-6979 28 8 2001 Aug J. Clin. Periodontol. Utilisation of locally delivered doxycycline in non-surgical treatment of chronic periodontitis. A comparative multi-centre trial of 2 treatment approaches. 753-61 In the present 6-month multicentre trial, the outcome of 2 different approaches to non-surgical treatment of chronic periodontitis, both involving the use of a locally delivered controlled-release doxycycline, was evaluated. 105 adult patients with moderately advanced chronic periodontitis from 3 centres participated in the trial. Each patient had to present with at least 8 periodontal sites in 2 jaw quadrants with a probing pocket depth (PPD) of > or =5 mm and bleeding following pocket probing (BoP), out of which at least 2 sites had to be > or =7 mm and a further 2 sites > or =6 mm. Following a baseline examination, including assessments of plaque, PPD, clinical attachment level (CAL) and BoP, careful instruction in oral hygiene was given. The patients were then randomly assigned to one of two treatment groups: scaling/root planing (SRP) with local analgesia or debridement (supra- and subgingival ultrasonic instrumentation without analgesia). The "SRP" group received a single episode of full-mouth supra-/subgingival scaling and root planing under local analgesia. In addition, at a 3-month recall visit, a full-mouth supra-/subgingival debridement using ultrasonic instrumentation was provided. This was followed by subgingival application of an 8.5% w/w doxycycline polymer at sites with a remaining PPD of > or =5 mm. The patients of the "debridement" group were initially subjected to a 45-minute full-mouth debridement with the use of an ultrasonic instrument and without administration of local analgesia, and followed by application of doxycycline in sites with a PPD of > or =5 mm. At month 3, sites with a remaining PPD of > or =5 mm were subjected to scaling and root planing. Clinical re-examinations were performed at 3 and 6 months. At 3 months, the proportion of sites showing PPD of < or =4 mm was significantly higher in the "debridement" group than in the "SRP" group (58% versus 50%; p<0.05). The CAL gain at 3 months amounted to 0.8 mm in the "debridement" group and 0.5 mm in the "SRP" group (p=0.064). The proportion of sites demonstrating a clinically significant CAL gain (> or =2 mm) was higher in the "debridement" group than in the "SRP" group (38% versus 30%; p<0.05). At the 6-month examination, no statistically significant differences in PPD or CAL were found between the two treatment groups. BoP was significantly lower for the "debridement" group than for the "SRP" group (p<0.001) both at 3- and 6 months. The mean total treatment time (baseline and 3-month) for the "SRP" patients was 3:11 h, compared to 2:00 h for the patients in the "debridement" group (p<0.001). The results indicate that simplified subgingival instrumentation combined with local application of doxycycline in deep periodontal sites can be considered as a justified approach for non-surgical treatment of chronic periodontitis. Department of Periodontology, Institute of Odontology, Göteborg University, SE 405 30 Göteborg, Sweden. wennstrom@odontologi.gu.se Wennström J L JL Newman H N HN MacNeill S R SR Killoy W J WJ Griffiths G S GS Gillam D G DG Krok L L Needleman I G IG Weiss G G Garrett S S eng fre ger Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Denmark J Clin Periodontol 0425123 0303-6979 0 Anti-Bacterial Agents 24390-14-5 doxycycline hyclate 564-25-0 Doxycycline D IM Adult Aged Anti-Bacterial Agents administration & dosage Chronic Disease Clinical Protocols Cost-Benefit Analysis Debridement Dental Scaling methods Doxycycline administration & dosage analogs & derivatives Drug Compounding Female Gingival Hemorrhage etiology Humans Male Middle Aged Periodontal Pocket pathology Periodontitis complications drug therapy pathology therapy Prospective Studies Root Planing methods Single-Blind Method Treatment Outcome 11488864 2001 08 07 2001 10 25 2006 11 15

0905-7161 12 4 2001 Aug Clin Oral Implants Res Early endosseous integration enhanced by dual acid etching of titanium: a torque removal study in the rabbit. 350-7 Textured implant surfaces are thought to enhance endosseous integration. Torque removal forces have been used as a biomechanical measure of anchorage, or endosseous integration, in which the greater forces required to remove implants may be interpreted as an increase in the strength of bony integration. The purpose of this study was to compare the torque resistance to removal of screw-shaped titanium implants having a dual acid-etched surface (Osseotite) with implants having either a machined surface, or a titanium plasma spray surface that exhibited a significantly more complex surface topography. Three custom screw-shaped implant types - machined, dual acid-etched (DAE), and titanium plasma sprayed (TPS) - were used in this study. Each implant surface was characterized by scanning electron microscopy and optical profilometry. One DAE implant was placed into each distal femur of eighteen adult New Zealand White rabbits along with one of the other implant types. Thus, each rabbit received two DAE implants and one each of the machined, or TPS, implants. All implants measured 3.25 mm in diameter x 4.00 mm in length without holes, grooves or slots to resist rotation. Eighteen rabbits were used for reverse torque measurements. Groups of six rabbits were sacrificed following one, two and three month healing periods. Implants were removed by reverse torque rotation with a digital torque-measuring device. Three implants with the machined surface preparation failed to achieve endosseous integration. All other implants were anchored by bone. Mean torque values for machined, DAE and TPS implants at one, two and three months were 6.00+/-0.64 N-cm, 9.07+/-0.67 N-cm and 6.73+/-0.95 N-cm; 21.86+/-1.37 N-cm, 27.63+/-3.41 N-cm and 27.40+/-3.89 N-cm; and 27.48+/-1.61 N-cm, 44.28+/-4.53 N-cm and 59.23+/-3.88 N-cm, respectively. Clearly, at the earliest time point the stability of DAE implants was comparable to that of TPS implants, while that of the machined implants was an order of magnitude lower. The TPS implants increased resistance to reverse torque removal over the three-month period. The results of this study confirm our previous results that demonstrated enhanced bony anchorage to dual acid-etched implants as compared to machined implants. Furthermore, the present results indicate that dual acid etching of titanium enhances early endosseous integration to a level which is comparable to that achieved by the topographically more complex TPS surfaces. Division of Associated Specialties, Section of Periodontics, UCLA School of Dentistry, Los Angeles, CA 90095, USA. pklok@ucla.edu Klokkevold P R PR Johnson P P Dadgostari S S Caputo A A Davies J E JE Nishimura R D RD eng fre ger Comparative Study Journal Article Research Support, Non-U.S. Gov't

Denmark Clin Oral Implants Res 9105713 0905-7161 0 Coated Materials, Biocompatible 0 Dental Implants 0 Sulfuric Acids 7440-32-6 Titanium 7647-01-0 Hydrochloric Acid 7664-93-9 sulfuric acid D Analysis of Variance Animals Coated Materials, Biocompatible Dental Implantation, Endosseous Dental Implants Dental Polishing Dental Prosthesis Design Device Removal Femur Hydrochloric Acid Implants, Experimental Metallurgy Osseointegration Rabbits Sulfuric Acids Surface Properties Titanium Torque 11488868 2001 08 07 2001 10 25 2011 02 15

0905-7161 12 4 2001 Aug Clin Oral Implants Res Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. 379-84 Porous beta-phase tricalcium phosphate particles (pTCP) (Cerasorb) were used in two patients to restore or augment alveolar bone prior to the placement of dental implants. In one patient, pTCP was used to fill a large alveolar defect in the posterior mandible after the removal of a residual cyst, and in another patient to augment the sinus floor. Biopsies were taken at the time of implant placement, 9.5 and 8 months after grafting, respectively, and processed for hard tissue histology. Goldner-stained histological sections showed considerable replacement of the bone substitute by bone and bone marrow. In the 9.5 months biopsy of the mandible, 34% of the biopsy consisted of mineralised bone tissue and 29% of remaining pTCP, while the biopsy at 8 months after sinus floor augmentation consisted of 20% mineralised bone and 44% remaining pTCP. Bone and osteoid were lying in close contact with the remaining pTCP and were also seen within the micropores of the grafted particles. Tartrate resistant-acid phosphatase (TRAP) multinuclear cells, presumably osteoclasts, were found surrounding, within and in close contact with the pTCP particles, suggesting active resorption of the bone substitute. Remodelling of immature woven bone into mature lamellar bone was also found. No histological signs of inflammation were detected. The limited data presented from these two cases suggest that this graft material, possibly by virtue of its porosity and chemical nature, may be a suitable bone substitute that can biodegrade and be replaced by new mineralising bone tissue. Department of Oral Cell Biology, ACTA, Vrije Universiteit, Vander Boechorststraat 7, 1081 BT Amsterdam, Netherlands. IR.Zerbo.Ocb.ACTA@med.vu.nl Zerbo I R IR Bronckers A L AL de Lange G L GL van Beek G J GJ Burger E H EH eng Case Reports Journal Article Research Support, Non-U.S. Gov't

Denmark Clin Oral Implants Res 9105713 0905-7161 0 Bone Substitutes 0 Calcium Phosphates 0 beta-tricalcium phosphate 7758-87-4 tricalcium phosphate D Absorbable Implants Aged Alveolar Ridge Augmentation methods Bone Regeneration drug effects Bone Substitutes pharmacology Calcium Phosphates pharmacology Humans Male Mandible surgery Maxillary Sinus surgery Middle Aged Oral Surgical Procedures, Preprosthetic Porosity 11520209 2001 08 24 2001 09 27 2004 11 17

0022-2623 44 18 2001 Aug 30 J. Med. Chem. Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity. 3001-13 This paper describes the synthesis of a series of azo compounds able to deliver 5-aminosalicylic acid (5-ASA) and a potent platelet activating factor (PAF) antagonist in a colon-specific manner for the purpose of treating ulcerative colitis. We found it possible to add an amino group on the aromatic moiety of our reported 1-[(1-acyl-4-piperidyl)methyl]-1H-2-methylimidazo[4,5-c]pyridine derivatives or on British Biotech compounds BB-882 and BB-823 maintaining a high level of activity as PAF antagonist. A selected compound UR-12715 (49c) showed an IC(50) of 8 nM in the in vitro PAF-induced aggregation assay, and an ID(50) of 29 microg/kg in the in vivo PAF-induced hypotension test in normotensive rats. Through attachment of 49c to the 5-ASA via azo functionality we obtained UR-12746 (70). Pharmacokinetics experiments with [14C]-70 allow us to reach the following conclusions, critical in the design of these new prodrugs of 5-ASA. Neither the whole molecule 70 nor the carrier 49c were absorbed after oral administration of [14C]-70 in rat as was demonstrated by the absence of plasma levels of radioactivity and the high recovery of it in feces. Effective cleavage of azo bond (84%) by microflora in the colon is achieved. These facts ensure high topical concentrations of 5-ASA and 49c in the colon. Additionally, 70 exhibited a potent anticolitic effect in the trinitrobenzenesulfonic acid-induced colitis model in the rat. This profile suggests that UR-12746 (70) provides an attractive new approach to the treatment of ulcerative colitis. Research Center, J. Uriach & Cía.S.A., Degà Bahí 59-67, 08026 Barcelona, Spain. chem-carceller@uriach.com Carceller E E Salas J J Merlos M M Giral M M Ferrando R R Escamilla I I Ramis J J García-Rafanell J J Forn J J eng Journal Article

United States J Med Chem 9716531 0022-2623 0 1-((1-(3-(4-aminophenyl)-3-phenylpropenoyl)-4-piperidyl)methyl)-1H-2-methylimidazo(4,5-c)pyridine 0 Amines 0 Aminosalicylic Acids 0 Anti-Inflammatory Agents, Non-Steroidal 0 Aza Compounds 0 Azo Compounds 0 Imidazoles 0 Platelet Activating Factor 0 Prodrugs 0 Pyridines 0 UR 12746 2508-19-2 Trinitrobenzenesulfonic Acid 89-57-6 Mesalamine IM Amines chemical synthesis chemistry pharmacology Aminosalicylic Acids Animals Anti-Inflammatory Agents, Non-Steroidal chemical synthesis chemistry pharmacokinetics pharmacology Aza Compounds chemical synthesis chemistry pharmacology Azo Compounds chemical synthesis chemistry pharmacokinetics pharmacology Colitis, Ulcerative chemically induced drug therapy Drug Evaluation, Preclinical Female Hypotension drug therapy Imidazoles chemical synthesis chemistry pharmacology Male Mesalamine chemical synthesis chemistry pharmacology Platelet Activating Factor antagonists & inhibitors Platelet Aggregation drug effects Prodrugs chemical synthesis chemistry pharmacokinetics pharmacology Pyridines chemical synthesis chemistry pharmacology Rats Rats, Sprague-Dawley Rats, Wistar Stereoisomerism Structure-Activity Relationship Trinitrobenzenesulfonic Acid 11525160 2001 08 28 2001 08 30 2004 11 17

0250-5525 124 2000 Schweiz Med Wochenschr Suppl 32nd Annual meeting of the Swiss Society of Nephrology. Lausanne, 14-15 December 2000. Abstracts. 1S-20S eng fre ger Congresses Overall

Switzerland Schweiz Med Wochenschr Suppl 7708316 0250-5525 IM Animals Humans Kidney Diseases Nephrology 11524736 2001 08 28 2001 12 12 2006 11 15

1098-1004 18 3 2001 Sep Hum. Mutat. Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome. 251 Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases. Hum Mutat 18:251, 2001. Copyright 2001 Wiley-Liss, Inc. Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk Comeglio P P Evans A L AL Brice G W GW Child A H AH eng Journal Article Research Support, Non-U.S. Gov't

United States Hum Mutat 9215429 1059-7794 0 Microfilament Proteins 0 fibrillin IM Hum Mutat. 2001 Dec;18(6):546-7 11748851 Adult Base Sequence Child, Preschool Female Frameshift Mutation Great Britain Humans Male Marfan Syndrome genetics Microfilament Proteins genetics Middle Aged Mutation Mutation, Missense Sequence Deletion 11543891 2001 09 06 2001 09 27 2011 11 17

0198-8859 62 9 2001 Sep Hum. Immunol. The origin of Palestinians and their genetic relatedness with other Mediterranean populations. 889-900 The genetic profile of Palestinians has, for the first time, been studied by using human leukocyte antigen (HLA) gene variability and haplotypes. The comparison with other Mediterranean populations by using neighbor-joining dendrograms and correspondence analyses reveal that Palestinians are genetically very close to Jews and other Middle East populations, including Turks (Anatolians), Lebanese, Egyptians, Armenians, and Iranians. Archaeologic and genetic data support that both Jews and Palestinians came from the ancient Canaanites, who extensively mixed with Egyptians, Mesopotamian, and Anatolian peoples in ancient times. Thus, Palestinian-Jewish rivalry is based in cultural and religious, but not in genetic, differences. The relatively close relatedness of both Jews and Palestinians to western Mediterranean populations reflects the continuous circum-Mediterranean cultural and gene flow that have occurred in prehistoric and historic times. This flow overtly contradicts the demic diffusion model of western Mediterranean populations substitution by agriculturalists coming from the Middle East in the Mesolithic-Neolithic transition. Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain. aarnaiz@eucmax.sim.ucm.es Arnaiz-Villena A A Elaiwa N N Silvera C C Rostom A A Moscoso J J Gómez-Casado E E Allende L L Varela P P Martínez-Laso J J eng Comparative Study Journal Article Research Support, Non-U.S. Gov't Retracted Publication

United States Hum Immunol 8010936 0198-8859 0 HLA Antigens 0 HLA-A Antigens 0 HLA-B Antigens 0 HLA-DQ Antigens 0 HLA-DQ beta-Chains 0 HLA-DQB1 antigen 0 HLA-DR Antigens 0 HLA-DRB1 Chains IM Hum Immunol. 2001 Oct;62(10):1064 11600211 Suciu-Foca N, Lewis R. Hum Immunol. 2001 Oct;62(10):1063 11600210 Alleles Arabs genetics Gene Frequency Greece ethnology HLA Antigens genetics HLA-A Antigens genetics HLA-B Antigens genetics HLA-DQ Antigens HLA-DQ beta-Chains HLA-DR Antigens genetics HLA-DRB1 Chains Haplotypes genetics Humans Islam Israel Jews genetics Linkage Disequilibrium Mediterranean Region Middle East Phylogeny Polymorphism, Genetic genetics 11562649 2001 09 19 2002 02 22 2005 11 16

0891-5245 15 5 2001 Sep-Oct J Pediatr Health Care Educating parents about normal stool pattern changes in infants. 269-74 Pediatric Nurse Practitioner Program at Ohio State University College of Nursing, Columbus, USA. Arias A A Bennison J J Justus K K Thurman D D eng Journal Article Review

United States J Pediatr Health Care 8709735 0891-5245 N J Pediatr Health Care. 2001 Sep-Oct;15(5):270-1 11858131 Adolescent Child Child, Preschool Consumer Satisfaction Defecation Feces chemistry Health Education methods Humans Infant Infant, Newborn Ohio Parenting 13 11567133 2001 09 21 2001 10 04 2007 03 19

0036-8075 293 5538 2001 Sep 21 Science Changes in seismic anisotropy after volcanic eruptions: evidence from Mount Ruapehu. 2231-3 The eruptions of andesite volcanoes are explosively catastrophic and notoriously difficult to predict. Yet changes in shear waveforms observed after an eruption of Mount Ruapehu, New Zealand, suggest that forces generated by such volcanoes are powerful and dynamic enough to locally overprint the regional stress regime, which suggests a new method of monitoring volcanoes for future eruptions. These results show a change in shear-wave polarization with time and are interpreted as being due to a localized stress regime caused by the volcano, with a release in pressure after the eruption. Institute of Geophysics, Victoria University of Wellington, Wellington, New Zealand. Miller V V Savage M M eng Journal Article

United States Science 0404511 0036-8075 11473127 2001 09 24 2001 11 01 2004 11 17

0021-9258 276 39 2001 Sep 28 J. Biol. Chem. Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium. 36520-9 We have used the highly selective alpha(4)beta(1) inhibitor 2S-[(1-benzenesulfonyl-pyrrolidine-2S-carbonyl)-amino]-4-[4-methyl-2S-(methyl-[2-[4-(3-o-tolyl-ureido)-phenyl]-acetyl]-amino)-pentanoylamino]-butyric acid (BIO7662) as a model ligand to study alpha(4)beta(1) integrin-ligand interactions on Jurkat cells. Binding of [(35)S]BIO7662 to Jurkat cells was dependent on the presence of divalent cations and could be blocked by treatment with an excess of unlabeled inhibitor or with EDTA. K(D) values for the binding of BIO7662 to Mn(2+)-activated alpha(4)beta(1) and to the nonactivated state of the integrin that exists in 1 mm Mg(2+), 1 mm Ca(2+) were <10 pm, indicating that it has a high affinity for both activated and nonactivated integrin. No binding was observed on alpha(4)beta(1) negative cells. Through an analysis of the metal ion dependences of ligand binding, several unexpected findings about alpha(4)beta(1) function were made. First, we observed that Ca(2+) binding to alpha(4)beta(1) was stimulated by the addition of BIO7662. From solution binding studies on purified alpha(4)beta(1), two types of Ca(2+)-binding sites were identified, one dependent upon and the other independent of BIO7662 binding. Second, we observed that the metal ion dependence of ligand binding was affected by the affinity of the ligand for alpha(4)beta(1). ED(50) values for the metal ion dependence of the binding of BIO7762 and the binding of a lower affinity ligand, BIO1211, differed by 2-fold for Mn(2+), 30-fold for Mg(2+), and >1000-fold for Ca(2+). Low Ca(2+) (ED(50) = 5-10 microm) stimulated the binding of BIO7662 to alpha(4)beta(1). The effects of microm Ca(2+) closely resembled the effects of Mn(2+) on alpha(4)beta(1) function. Third, we observed that the rate of BIO7662 binding was dependent on the metal ion concentration and that the ED(50) for the metal ion dependence of BIO7662 binding was affected by the concentration of the BIO7662. These studies point to an even more complex interplay between metal ion and ligand binding than previously appreciated and provide evidence for a three-component coupled equilibrium model for metal ion-dependent binding of ligands to alpha(4)beta(1). Biogen, Inc., Cambridge, Massachusetts 02142, USA. Chen L L LL Whitty A A Scott D D Lee W C WC Cornebise M M Adams S P SP Petter R C RC Lobb R R RR Pepinsky R B RB eng Journal Article 2001 07 25

United States J Biol Chem 2985121R 0021-9258 0 2-((1-benzenesulfonylpyrrolidine-2-carbonyl)amino)-4-(4-methyl-2-(methyl-(2-(4-(3-o-tolylureido)phenyl)acetyl)amino)pentanoylamino)butyric acid 0 Benzoic Acids 0 Cations 0 Dipeptides 0 Integrin alpha4beta1 0 Integrins 0 Ions 0 Ligands 0 Phenylurea Compounds 0 Receptors, Lymphocyte Homing 60-00-4 Edetic Acid 7439-95-4 Magnesium 7439-96-5 Manganese 7440-70-2 Calcium IM Benzoic Acids pharmacology Calcium metabolism pharmacology Cations Dipeptides pharmacology Dose-Response Relationship, Drug Edetic Acid pharmacology Humans Integrin alpha4beta1 Integrins antagonists & inhibitors chemistry metabolism Ions Jurkat Cells Kinetics Ligands Magnesium pharmacology Manganese pharmacology Models, Chemical Phenylurea Compounds pharmacology Protein Binding Receptors, Lymphocyte Homing antagonists & inhibitors chemistry metabolism Time Factors 11583040 2001 10 02 2001 10 04 2006 11 15

0084-6597 28 2000 Annu Rev Earth Planet Sci Understanding oblique impacts from experiments, observations, and modeling. 141-67 Natural impacts in which the projectile strikes the target vertically are virtually nonexistent. Nevertheless, our inherent drive to simplify nature often causes us to suppose most impacts are nearly vertical. Recent theoretical, observational, and experimental work is improving this situation, but even with the current wealth of studies on impact cratering, the effect of impact angle on the final crater is not well understood. Although craters' rims may appear circular down to low impact angles, the distribution of ejecta around the crater is more sensitive to the angle of impact and currently serves as the best guide to obliquity of impacts. Experimental studies established that crater dimensions depend only on the vertical component of the impact velocity. The shock wave generated by the impact weakens with decreasing impact angle. As a result, melting and vaporization depend on impact angle; however, these processes do not seem to depend on the vertical component of the velocity alone. Finally, obliquity influences the fate of the projectile: in particular, the amount and velocity of ricochet are a strong function of impact angle. Lunar and Planetary Lab., University of Arizona, Tucson, 84721, USA. betty@lpl.arizona.edu Pierazzo E E Melosh H J HJ eng Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

United States Annu Rev Earth Planet Sci 100971465 0084-6597 S Computer Simulation Evolution, Planetary Gravitation Meteoroids Models, Theoretical Moon Planets 96 00026602 NASA Discipline Exobiology Non-NASA Center Melosh H J HJ U AZ, Tucson Grant numbers: NAGW-5159, NAGW-428. 11580607 2001 10 02 2001 10 25 2006 11 15

0031-9007 87 13 2001 Sep 24 Phys. Rev. Lett. Maximal height scaling of kinetically growing surfaces. 136101 The scaling properties of the maximal height of a growing self-affine surface with a lateral extent L are considered. In the late-time regime its value measured relative to the evolving average height scales like the roughness: h*(L) approximately L alpha. For large values its distribution obeys logP(h*(L)) approximately (-)A(h*(L)/L(alpha))(a). In the early-time regime where the roughness grows as t(beta), we find h*(L) approximately t(beta)[lnL-(beta/alpha)lnt+C](1/b), where either b = a or b is the corresponding exponent of the velocity distribution. These properties are derived from scaling and extreme-value arguments. They are corroborated by numerical simulations and supported by exact results for surfaces in 1D with the asymptotic behavior of a Brownian path. Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA. Raychaudhuri S S Cranston M M Przybyla C C Shapir Y Y eng Journal Article Research Support, U.S. Gov't, Non-P.H.S. 2001 09 05

United States Phys Rev Lett 0401141 0031-9007 IM Bacteria growth & development Crystallization Kinetics Models, Theoretical Surface Properties 11600210 2001 10 15 2001 10 25

0198-8859 62 10 2001 Oct Hum. Immunol. Editorial. Anthropology and genetic markers. 1063 Suciu-Foca N N Lewis R R eng Retraction of Publication

United States Hum Immunol 8010936 0198-8859 IM Arnaiz-Villena A, Elaiwa N, Silvera C, Rostom A, Moscoso J, Gómez-Casado E, Allende L, Varela P, Martínez-Laso J. Hum Immunol. 2001 Sep;62(9):889-900 11543891 11600211 2001 10 15 2001 10 25 2004 11 17

0198-8859 62 10 2001 Oct Hum. Immunol. Letter from the ASHI president and council. 1064 Tyan D B DB eng Comment Letter

United States Hum Immunol 8010936 0198-8859 IM Hum Immunol. 2001 Sep;62(9):889-900 11543891 Ethics, Medical Histocompatibility Humans Immunogenetics Publishing Societies, Medical United States 11686176 1982 01 01 1982 01 01 2007 11 15

0094-6133 1979 Jan-Feb Malpract Dig How physicians may minimize their chances of becoming involved in an informed consent claim. 1-2 Bower John J JJ eng Journal Article

United States Malpract Dig 9879884 0094-6133 E Consent Forms Humans Informed Consent Jurisprudence Malpractice Records as Topic 12517 KIE BoB Subject Heading: INFORMED CONSENT 11686167 1990 10 17 1990 10 17 2007 11 15

8756-2057 25-26 1990 Jan-Apr Report Hum Reprod Law The dilemma of the Webster decision: deconstitutionalizing the trimester system. 276-92 Kindregan Charles P CP eng Journal Article

United States Report Hum Reprod Law 100971950 8756-2057 E Abortion, Eugenic Abortion, Induced Abortion, Therapeutic Beginning of Human Life Civil Rights Embryonic and Fetal Development Fetal Viability Fetus Government Regulation Great Britain History Humans International Cooperation Internationality Jurisprudence Legislation as Topic Life Pregnancy Pregnant Women Privacy Religion Social Control, Formal State Government Supreme Court Decisions United States 31521 Abortion Act 1967 (Great Britain) Genetics and Reproduction Legal Approach Roe v. Wade Webster v. Reproductive Health Services 63 fn. KIE BoB Subject Heading: abortion/legal aspects 11694165 2001 11 05 2001 12 28 2006 11 07

0098-7484 286 17 2001 Nov 7 JAMA msJAMA: Breast reconstruction: one woman's choice. 2163 Bily L L eng Journal Article

United States JAMA 7501160 0098-7484 AIM IM Body Image Decision Making Female Humans Mammaplasty methods psychology Mastectomy psychology 11704686 2001 11 19 2001 12 28 2011 11 17

0028-4793 345 22 2001 Nov 29 N. Engl. J. Med. Recognition and management of anthrax--an update. 1621-6 Department of Medicine, Massachusetts General Hospital, Boston 02114-2696, USA. Swartz M N MN eng Journal Article Review 2001 11 06

United States N Engl J Med 0255562 0028-4793 0 Anthrax Vaccines 0 Penicillins AIM IM N Engl J Med. 2002 Mar 21;346(12):943-5; discusson 943-5 11911137 N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5 11907299 N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5 11911138 N Engl J Med. 2002 Mar 21;346(12):943-5; author reply 943-5 11911136 N Engl J Med 2002 Feb 21;346(8):634 Anthrax diagnosis drug therapy epidemiology prevention & control Anthrax Vaccines Antibiotic Prophylaxis Bacillus anthracis pathogenicity Bioterrorism Clinical Laboratory Techniques Diagnosis, Differential Gastrointestinal Diseases diagnosis microbiology Humans Infection Control methods Meningitis, Bacterial diagnosis microbiology Penicillins therapeutic use Respiratory Tract Infections diagnosis drug therapy microbiology Skin Diseases, Bacterial diagnosis microbiology Spores, Bacterial Virulence 11 11731716 2001 12 03 2002 02 28 2005 11 16

0031-7012 64 1 2002 Jan Pharmacology Progress in the search for ideal drugs. 1-7 The search for ideal drugs to improve patient care requires applications of modern scientific methods to both discovery and development. Using these modern methods, the pharmaceutical industry with strong academic and government collaboration has introduced in the last 25 years many new drugs that approach the ideal. After reviewing Björnsson's classification of drug action and the notion of contributory causality, this commentary defines an ideal drug from the perspectives of pharmacodynamics, pharmacokinetics, and therapeutics. Examples of new drugs for hypertension, heart disease, stroke, osteoporosis, asthma, ulcer, and migraine headaches are described. Finally, the profound implications of progress in developing ideal drugs not only for the patient but also for the academic, educational, and regulatory establishments are briefly reviewed. Copyright 2002 S. Karger AG, Basel Department of Medicine, Robert Wood Johnson Medical School, Piscataway, NJ, USA. Spector Reynold R eng Journal Article Review

Switzerland Pharmacology 0152016 0031-7012 0 Pharmaceutical Preparations IM Drug Industry Drug Therapy trends Humans Pharmaceutical Preparations classification Pharmacokinetics Pharmacology 25 11748851 2001 12 18 2002 03 07 2006 11 15

1098-1004 18 6 2001 Dec Hum. Mutat. Erratum: Detection of six novel FBN1 mutations in British patients affected by Marfan syndrome. 546-7 Marfan syndrome (MFS), an autosomal dominant disorder of the extracellular matrix, is due to mutations in fibrillin-1 (FBN1) gene. Investigations carried out in the last decade, unveiled the unpredictability of the site of the mutation, which could be anywhere in the gene. FBN1 mutations have been reported in a spectrum of diseases related to MFS, with no clear evidence for a phenotype-genotype correlation. In this paper we analysed 10 British patients affected by MFS and we were able to characterise five novel missense mutations (C474W, C1402Y, G1987R, C2153Y, G2536R), one novel frameshift mutation (7926delC), one already described mutation (P1424A) and one FBN1 variant (P1148A) classified as a polymorphism in the Asian population. Four out of the five novel missense mutations involved either cysteines or an amino acid conserved in the domain structure. The mutation yield in this study is calculated at 80.0% (8/10), thus indicating that SSCA is a reliable and cost-effective technique for the screening of such a large gene. Our results suggest that this method is reliable to search for FBN1 mutations and that FBN1 screening could be a helpful tool to confirm and possibly anticipate the clinical diagnosis in familial cases. Copyright 2001 Wiley-Liss, Inc. Department of Cardiological Sciences, St. George's Hospital Medical School, London, UK. p.comeglio@sghms.ac.uk Comeglio P P Evans A L AL Brice G W GW Child A H AH eng Corrected and Republished Article Journal Article Research Support, Non-U.S. Gov't

United States Hum Mutat 9215429 1059-7794 0 Microfilament Proteins 0 fibrillin 9007-49-2 DNA IM Hum Mutat. 2001 Sep;18(3):251 11524736 Adult Base Sequence Child, Preschool DNA chemistry genetics DNA Mutational Analysis Female Frameshift Mutation Great Britain Humans Male Marfan Syndrome genetics pathology Microfilament Proteins genetics Middle Aged Mutation Mutation, Missense Polymorphism, Genetic Polymorphism, Single-Stranded Conformational 11748856 2001 12 18 2002 03 07 2007 11 15

1098-1004 18 6 2001 Dec Hum. Mutat. Eight novel germline MLH1 and MSH2 mutations in hereditary non-polyposis colorectal cancer families from Spain. 549 Germline mutations in the MLH1 and MSH2 genes, account for the majority of HNPCC families. We have screened such families from Spain by using DGGE analysis and subsequent direct sequencing techniques. In eight families we identified six novel MLH1 and two novel MSH2 mutations comprising one frame shift mutation (c.1420 del C), two missense mutations (L622H and R687W), two splice site mutations (c.1990-1 G>A and c.453+2 T>C and one nonsense mutation (K329X) in the MLH1 gene as well as two frame shift mutations (c.1979-1980 del AT and c.1704-1705 del AG) in the MSH2 gene. Our analysis contributes to the further characterization of the mutational spectrum of MLH1 and MSH2 genes in HNPCC families. Copyright 2001 Wiley-Liss, Inc. Laboratory of Molecular Oncology, San Carlos University Hospital, 28040 Madrid, Spain. Godino J J de La Hoya M M Diaz-Rubio E E Benito M M Caldés T T eng OMIM 114500 120435 120436 600258 600259 600678 Journal Article Research Support, Non-U.S. Gov't

United States Hum Mutat 9215429 1059-7794 0 Adaptor Proteins, Signal Transducing 0 Carrier Proteins 0 DNA-Binding Proteins 0 MLH1 protein, human 0 Neoplasm Proteins 0 Nuclear Proteins 0 Proto-Oncogene Proteins 9007-49-2 DNA EC 3.6.1.3 MSH2 protein, human EC 3.6.1.3 MutS Homolog 2 Protein IM Adaptor Proteins, Signal Transducing Carrier Proteins Colorectal Neoplasms, Hereditary Nonpolyposis genetics DNA chemistry genetics DNA Mutational Analysis DNA-Binding Proteins Family Health Female Germ-Line Mutation Humans Male MutS Homolog 2 Protein Neoplasm Proteins genetics Nuclear Proteins Proto-Oncogene Proteins genetics Spain 11885531 2002 02 05 2002 04 08 2006 11 15

0028-2200 99 7 1992 Jul Ned Tijdschr Tandheelkd [Microbiological diagnostics in periodontal treatment]. 245-6 Periodontal diseases are bacterial infections. The rationale for the use of microbiological diagnostics in periodontal treatment of severe periodontitis patients is discussed as well as the use of adjunct antimicrobial therapy for the elimination of specific bacterial species. Uit de vakgroep Orale Microbiologie van het Academisch Centrum Tandheelkunde Amsterdam (ACTA). de Graaff J J van Winkelhoff A J AJ dut English Abstract Journal Article Review Microbiologische diagnostiek in de paradontologie.

Netherlands Ned Tijdschr Tandheelkd 0400771 0028-2200 0 Anti-Bacterial Agents D Actinomycetales Infections drug therapy Anti-Bacterial Agents therapeutic use Humans Hygiene Periodontal Diseases diagnosis drug therapy microbiology Periodontitis diagnosis drug therapy microbiology Risk Factors 6 12179763 1991 12 03 1991 12 03 2003 11 14

1226-0282 10 2 1990 Dec Bogeon sahoe nonjib Recent changes in the population control policy and its future directions in Korea. 152-73 Cho N H NH Seo M H MH Tan B A BA eng Journal Article

KOREA, REPUBLIC OF Bogeon sahoe nonjib 9422396 1226-0282 J Adult Age Factors Aged Asia Birth Rate Conservation of Natural Resources Contraception Delivery of Health Care Demography Dependency (Psychology) Developing Countries Economics Employment Environment Family Planning Services Far East Fertility Health Health Manpower Health Planning Health Services Korea Maternal-Child Health Centers Organization and Administration Population Population Characteristics Population Density Population Dynamics Population Growth Primary Health Care Program Evaluation Public Policy Public Sector Research Social Welfare Socioeconomic Factors Sterilization, Reproductive 067656 00204408 The total fertility rate (TFR) in Korea decreased from 6.0 to 1.6 over the period 1960-87. A national family planning program and socioeconomic development have played roles in this decline. Should this most recent TFR prevail, the nation's population will increase to 50.2 million by 2020, shifting to negative growth thereafter. Demographic aging and labor shortages will ensue. Future population policy should consider Korea's socioeconomic conditions and its burgeoning population in relation to the available land area, and aim to maintain a minimum positive population growth rate. In this context, this paper considers future population policy directions for Korea, acknowledging that its strategies and objectives must change. Postponing reaching the goal of zero population growth rate is suggested to allow a moderate population infusion of economically active individuals. These people will help facilitate greater economic development and work to improve the quality of life in Korea. Strengthened family planning/maternal-child health programs which encourage and support temporary contraceptive methods instead of sterilization will help to achieve this goal. Improving qualitative program aspects should be the center of attention in these programs. The paper also calls upon the Korea Institute for Health and Social Affairs to strengthen its research and evaluation capabilities. Adult Age Factors Aged Asia Birth Rate Carrying Capacity Contraception Contraceptive Methods Delivery Of Health Care Demographic Aging Demographic Factors Demographic Transition Dependency Burden Developing Countries Eastern Asia Economic Development Economic Factors Environment Family Planning Family Planning Programs Fertility Fertility Measurements Fertility Rate Health Health Services Human Resources Korea Labor Force Macroeconomic Factors Maternal-child Health Services Microeconomic Factors Natural Resources Organization And Administration Policy Population Population Characteristics Population Decrease Population Dynamics Population Growth Population Policy Population Pressure Population Size Primary Health Care Program Evaluation Programs Public Sector Research Methodology Social Policy Social Welfare Socioeconomic Factors Sterilization, Sexual Total Fertility Rate--changes Zero Population Growth TJ: JOURNAL OF POPULATION, HEALTH AND SOCIAL WELFARE 12349809 2000 12 06 2000 12 06 2007 11 15

0251-7329 37 2 2000 UN Chron Gender and globalization. A century in retrospect. 69-70 Chinkin C C eng Journal Article

UNITED STATES UN Chron 8305532 0251-7329 J Economics Evaluation Studies as Topic Interpersonal Relations Social Change Socioeconomic Factors Women's Rights 152034 00297373 In the past, power structures of the nation-State have been organized around patriarchal assumptions, granting men monopoly over power, authority, and wealth. A number of structures have been erected to achieve this imbalance, which have disguised its inequity by making it appear as natural and universal. However, with globalization, this centralization of power within the Sovereign State has been fragmented. Although globalization opens up new spaces by weakening the nation-State, subsequently making possible the undermining of traditional gender hierarchies and devising new bases for gender relations, the reality that the State is no longer the sole institution that can define identity and belonging within it has denied women the space to assert their own claims to gendered self-determination. In this regard, globalization has impacted upon gender relations in complex and contradictory ways. This paper discusses such impacts of globalization on gender relations. Overall, it has become apparent that forms of inequality still exist regardless of a State's prevailing political ideology. Their manifestations may differ, but the reality of women's subordination remains constant. Critique Economic Factors Gender Issues Gender Relations Social Change Socioeconomic Factors Women's Status World TJ: UN CHRONICLE 11831940 2002 02 08 2002 02 25 2004 11 17

0003-9950 120 2 2002 Feb Arch. Ophthalmol. Republication of color figures. 234-7 Dushku Nicholas N John Molykutty K MK Schultz Gregory S GS Reid Ted W TW eng Comment Letter

United States Arch Ophthalmol 7706534 0003-9950 EC 3.4.24.- Matrix Metalloproteinases AIM IM Arch Ophthalmol. 2001 May;119(5):695-706 11346397 Epithelial Cells enzymology pathology Fibroblasts enzymology pathology Humans Immunoenzyme Techniques Limbus Corneae pathology Matrix Metalloproteinases metabolism Pterygium enzymology pathology 11838066 2002 02 12 2002 02 25 2008 11 21

0023-7205 99 3 2002 Jan 17 Lakartidningen [Unequal distribution of health resources. Research is not supported with consideration to the global significance of the diseases]. 148-9 josef.milerad@lakartidningen.se Milerad Josef J swe Biography Historical Article Journal Article Portraits Ojämn fördelning av hälsoresurser. Forskningspengar satsas inte i proportion till sjukdomars globala betydelse.

Sweden Lakartidningen 0027707 0023-7205 IM Health Care Rationing History, 20th Century Humans Nobel Prize Research Support as Topic economics organization & administration Sweden United States World Health Varmus Harold H 11858276 2002 02 21 2002 03 28 2008 11 21

0094-5765 48 5-12 2001 Mar-Jun Acta Astronaut Phase 1 research program overview. 845-51 The Phase 1 research program was unprecedented in its scope and ambitious in its objectives. The National Aeronautics and Space Administration committed to conducting a multidisciplinary long-duration research program on a platform whose capabilities were not well known, not to mention belonging to another country. For the United States, it provided the first opportunity to conduct research in a long-duration space flight environment since the Skylab program in the 1970's. Multiple technical as well as cultural challenges were successfully overcome through the dedicated efforts of a relatively small cadre of individuals. The program developed processes to successfully plan, train for and execute research in a long-duration environment, with significant differences identified from short-duration space flight science operations. Between August 1994 and June 1998, thousands of kilograms of research hardware was prepared and launched to Mir, and thousands of kilograms of hardware and data products were returned to Earth. More than 150 Principal Investigators from eight countries were involved in the program in seven major research disciplines: Advanced Technology; Earth Sciences; Fundamental Biology; Human Life Sciences; International Space Station Risk Mitigation; Microgravity; and Space Sciences. Approximately 75 long-duration investigations were completed on Mir, with additional investigations performed on the Shuttle flights that docked with Mir. The flight phase included the participation of seven US astronauts and 20 Russian cosmonauts. The successful completion of the Phase 1 research program not only resulted in high quality science return but also in numerous lessons learned to make the ISS experience more productive. The cooperation developed during the program was instrumental in its success. c2001 AIAA. Published by Elsevier Science Ltd. NASA Johnson Space Center, Houston, TX, USA. Uri J J JJ Lebedev O N ON eng Journal Article

England Acta Astronaut 9890631 0094-5765 S Biological Science Disciplines Equipment Design Exobiology Extraterrestrial Environment Humans International Cooperation Program Evaluation Research instrumentation organization & administration Russia Space Flight instrumentation organization & administration trends Spacecraft USSR United States United States National Aeronautics and Space Administration organization & administration Weightlessness 00027286 Flight Experiment Mir Project STS Shuttle Project long duration manned short duration 11858625 2002 02 22 2002 03 06 2004 11 17

0002-838X 65 3 2002 Feb 1 Am Fam Physician Information from your family doctor. Exercise for the elderly. 427-8 eng Journal Article Patient Education Handout

United States Am Fam Physician 1272646 0002-838X AIM IM Am Fam Physician. 2002 Feb 1;65(3):419-26 11858624 Aged Exercise Family Practice Health Promotion Humans 11869993 2002 02 28 2002 03 22 2004 11 17

1052-1577 27 4 2002 Feb Harv Health Lett By the way doctor... I'm 72 and was recently told that I am losing a bit of my sight because of macular degeneration. My doctor assured me that it was progressing very slowly, but also said there wasn't really anything to do about it. But I read that zinc or vitamins might help. Should I be taking them? 8 Lee Thomas H TH eng Journal Article

United States Harv Health Lett 9425764 1052-1577 0 Antioxidants 0 Vitamins 7440-66-6 Zinc K Aged Antioxidants therapeutic use Drug Therapy, Combination Humans Macular Degeneration prevention & control Vitamins therapeutic use Zinc therapeutic use 11876201 2002 03 04 2002 03 22 2007 11 15

1069-9422 5 3 1998 Life Support Biosph Sci Consumer acceptance of vegetarian sweet potato products intended for space missions. 339-46 Sweet potato is one of the crops selected for NASA's Advanced Life Support Program for potential long-duration lunar/Mars missions. This article presents recipes of products made from sweet potato and determines the consumer acceptability of products containing from 6% to 20% sweet potato on a dry weight basis. These products were developed for use in nutritious and palatable meals for future space explorers. Sensory evaluation (appearance/color, aroma, texture, flavor/taste, and overall acceptability) studies were conducted to determine the consumer acceptability of vegetarian products made with sweet potato using panelists at NASA/Johnson Space Center in Houston, TX. None of these products including the controls, contained any ingredient of animal origin with the exception of sweet potato pie. A 9-point hedonic scale (9 being like extremely and 1 being dislike extremely) was used to evaluate 10 products and compare them to similar commercially available products used as controls. The products tested were pancakes, waffles, tortillas, bread, pie, pound cake, pasta, vegetable patties, doughnuts, and pretzels. All of the products were either liked moderately or liked slightly with the exception of the sweet potato vegetable patties, which were neither liked nor disliked. Mean comparisons of sensory scores of sweet potato recipes and their controls were accomplished by using the Student t-test. Because of their nutritional adequacy and consumer acceptability, these products are being recommended to NASA's Advanced Life Support Program for inclusion in a vegetarian menu plan designed for lunar/Mars space missions. Center for Food and Environmental Systems for Human Exploration of Space, George Washington Carver Agricultural Experiment Station, Tuskegee University, Tuskegee, AL 36088, USA. Wilson C D CD Pace R D RD Bromfield E E Jones G G Lu J Y JY eng Journal Article Research Support, U.S. Gov't, Non-P.H.S.

United States Life Support Biosph Sci 9431217 1069-9422 S Diet, Vegetarian psychology Ecological Systems, Closed Evaluation Studies as Topic Food Habits psychology Food Preferences psychology Food Technology Humans Ipomoea batatas Life Support Systems Menu Planning Nutritive Value Space Flight United States United States National Aeronautics and Space Administration Weightlessness 00027330 NASA Discipline Life Support Systems Non-NASA Center Mortley D G DG Tuskegee U, AL Grant numbers: NCC 9-51, ALX-FS-2. 11892742 2002 03 13 2002 03 18 2009 07 23

0012-1606 242 2 2002 Feb 15 Dev. Biol. The major subacrosomal occupant of bull spermatozoa is a novel histone H2B variant associated with the forming acrosome during spermiogenesis. 376-87 Recent studies on the structural composition of mammalian sperm heads have shown a congregate of unidentified proteins occupying the periphery of the mammalian sperm nucleus, forming a layer of condensed cytosol. These proteins are the perinuclear theca (PT) and can be categorized into SDS-soluble and SDS-insoluble components. The present study focused on identifying the major SDS-insoluble PT protein, which we localized to the subacrosomal layer of bovine spermatozoa and cloned by immunoscreening a bull testicular cDNA library. The isolated clones encode a protein of 122 amino acids that bears 67% similarity with histone H2B and contains a predicted histone fold motif. The novel amino terminus of the protein contains a potential bipartite nuclear targeting sequence. Hence, we identified this prominent subacrosomal component as a novel H2B variant, SubH2Bv. Northern blot analyses of SubH2Bv mRNA expression showed that it is testis-specific and is also present in murid testes. Immunocytochemical analysis showed SubH2Bv intimately associates, temporally and spatially, with acrosome formation. While the molecular features of SubH2Bv are common to nuclear proteins, it is never seen developmentally within the nucleus of the spermatid. Considering its developmental and molecular characteristics, we have postulated roles of SubH2Bv in acrosome assembly and acrosome-nuclear docking. Copyright 2001 Academic Press. Department of Anatomy and Cell Biology, Queen's University, Kingston, Ontario, Canada, K7L 3N6. Aul Ritu B RB Oko Richard J RJ eng Corrected and Republished Article Journal Article Research Support, Non-U.S. Gov't

United States Dev Biol 0372762 0012-1606 0 DNA, Complementary 0 Histones 0 RNA, Messenger 63231-63-0 RNA IM Dev Biol. 2001 Nov 15;239(2):376-87 11784042 Acrosome chemistry metabolism ultrastructure Amino Acid Motifs Amino Acid Sequence Animals Base Sequence Blotting, Northern Blotting, Western Cattle DNA, Complementary metabolism Electrophoresis, Polyacrylamide Gel Histones chemistry Immunoblotting Immunohistochemistry Male Mice Molecular Sequence Data RNA metabolism RNA, Messenger metabolism Rats Reverse Transcriptase Polymerase Chain Reaction Seminiferous Epithelium metabolism Sequence Homology, Amino Acid Spermatogenesis Spermatozoa chemistry Testis metabolism 11909345 2002 03 22 2002 05 16 2003 11 03

0031-9007 88 10 2002 Mar 11 Phys. Rev. Lett. Measurement of B --> K*gamma branching fractions and charge asymmetries. 101805 The branching fractions of the exclusive decays B0-->K(*0)gamma and B+-->K(*+)gamma are measured from a sample of (22.74+/-0.36)x10(6) BB decays collected with the BABAR detector at the PEP-II asymmetric e(+)e(-) collider. We find B (B0-->K(*0)gamma) = [4.23+/-0.40(stat)+/-0.22(syst)]x10(-5), B(B+-->K(*+)gamma) = [3.83+/-0.62(stat)+/-0.22(syst)]x10(-5) and constrain the CP-violating charge asymmetry to be -0.170<A(CP)(B-->K(*)gamma)<0.082 at 90% C.L. Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux, France. Aubert B B Boutigny D D Gaillard J-M JM Hicheur A A Karyotakis Y Y Lees J P JP Robbe P P Tisserand V V Palano A A Chen G P GP Chen J C JC Qi N D ND Rong G G Wang P P Zhu Y S YS Eigen G G Reinertsen P L PL Stugu B B Abbott B B Abrams G S GS Borgland A W AW Breon A B AB Brown D N DN Button-Shafer J J Cahn R N RN Clark A R AR Gill M S MS Gritsan A V AV Groysman Y Y Jacobsen R G RG Kadel R W RW Kadyk J J Kerth L T LT Kluth S S Kolomensky Yu G YG Kral J F JF LeClerc C C Levi M E ME Liu T T Lynch G G Meyer A B AB Momayezi M M Oddone P J PJ Perazzo A A Pripstein M M Roe N A NA Romosan A A Ronan M T MT Shelkov V G VG Telnov A V AV Wenzel W A WA Zisman M S MS Bright-Thomas P G PG Harrison T J TJ Hawkes C M CM Knowles D J DJ O'Neale S W SW Penny R C RC Watson A T AT Watson N K NK Deppermann T T Goetzen K K Koch H H Krug J J Kunze M M Lewandowski B B Peters K K Schmuecker H H Steinke M M Andress J C JC Barlow N R NR Bhimji W W Chevalier N N Clark P J PJ Cottingham W N WN De Groot N N Dyce N N Foster B B McFall J D JD Wallom D D Wilson F F FF Abe K K Hearty C C Mattison T S TS McKenna J A JA Thiessen D D Jolly S S McKemey A K AK Tinslay J J Blinov V E VE Bukin A D AD Bukin D A DA Buzykaev A R AR Golubev V B VB Ivanchenko V N VN Korol A A AA Kravchenko E A EA Onuchin A P AP Salnikov A A AA Serednyakov S I SI Skovpen Yu I YI Telnov V I VI Yushkov A N AN Best D D Lankford A J AJ Mandelkern M M McMahon S S Stoker D P DP Ahsan A A Arisaka K K Buchanan C C Chun S S Branson J G JG MacFarlane D B DB Prell S S Rahatlou Sh Sh Raven G G Sharma V V Campagnari C C Dahmes B B Hart P A PA Kuznetsova N N Levy S L SL Long O O Lu A A Richman J D JD Verkerke W W Witherell M M Yellin S S Beringer J J Dorfan D E DE Eisner A M AM Frey A A Grillo A A AA Grothe M M Heusch C A CA Johnson R P RP Kroeger W W Lockman W S WS Pulliam T T Sadrozinski H H Schalk T T Schmitz R E RE Schumm B A BA Seiden A A Turri M M Walkowiak W W Williams D C DC Wilson M G MG Chen E E Dubois-Felsmann G P GP Dvoretskii A A Hitlin D G DG Metzler S S Oyang J J Porter F C FC Ryd A A Samuel A A Weaver M M Yang S S Zhu R Y RY Devmal S S Geld T L TL Jayatilleke S S Mancinelli G G Meadows B T BT Sokoloff M D MD Barillari T T Bloom P P Dima M O MO Fahey S S Ford W T WT Johnson D R DR Nauenberg U U Olivas A A Park H H Rankin P P Roy J J Sen S S Smith J G JG van Hoek W C WC Wagner D L DL Blouw J J Harton J L JL Krishnamurthy M M Soffer A A Toki W H WH Wilson R J RJ Zhang J J Brandt T T Brose J J Colberg T T Dahlinger G G Dickopp M M Dubitzky R S RS Hauke A A Maly E E Müller-Pfefferkorn R R Otto S S Schubert K R KR Schwierz R R Spaan B B Wilden L L Behr L L Bernard D D Bonneaud G R GR Brochard F F Cohen-Tanugi J J Ferrag S S Roussot E E T'Jampens S S Thiebaux Ch Ch Vasileiadis G G Verderi M M Anjomshoaa A A Bernet R R Khan A A Lavin D D Muheim F F Playfer S S Swain J E JE Falbo M M Borean C C Bozzi C C Dittongo S S Folegani M M Piemontese L L Treadwell E E Anulli F F Baldini-Ferroli R R Calcaterra A A de Sangro R R Falciai D D Finocchiaro G G Patteri P P Peruzzi I M IM Piccolo M M Xie Y Y Zallo A A Bagnasco S S Buzzo A A Contri R R Crosetti G G Fabbricatore P P Farinon S S Lo Vetere M M Macri M M Monge M R MR Musenich R R Pallavicini M M Parodi R R Passaggio S S Pastore F C FC Patrignani C C Pia M G MG Priano C C Robutti E E Santroni A A Morii M M Bartoldus R R Dignan T T Hamilton R R Mallik U U Cochran J J Crawley H B HB Fischer P-A PA Lamsa J J Meyer W T WT Rosenberg E I EI Benkebil M M Grosdidier G G Hast C C Höcker A A Lacker H M HM Laplace S S Lepeltier V V Lutz A M AM Plaszczynski S S Schune M H MH Trincaz-Duvoid S S Valassi A A Wormser G G Bionta R M RM Brigljević V V VV Lange D J DJ Mugge M M Shi X X van Bibber K K Wenaus T J TJ Wright D M DM Wuest C R CR Carroll M M Fry J R JR Gabathuler E E Gamet R R George M M Kay M M Payne D J DJ Sloane R J RJ Touramanis C C Aspinwall M L ML Bowerman D A DA Dauncey P D PD Egede U U Eschrich I I Gunawardane N J W NJ Nash J A JA Sanders P P Smith D D Azzopardi D E DE Back J J JJ Dixon P P Harrison P F PF Potter R J L RJ Shorthouse H W HW Strother P P Vidal P B PB Williams M I MI Cowan G G George S S Green M G MG Kurup A A Marker C E CE McGrath P P McMahon T R TR Ricciardi S S Salvatore F F Scott I I Vaitsas G G Brown D D Davis C L CL Allison J J Barlow R J RJ Boyd J T JT Forti A C AC Fullwood J J Jackson F F Lafferty G D GD Savvas N N Simopoulos E T ET Weatherall J H JH Farbin A A Jawahery A A Lillard V V Olsen J J Roberts D A DA Schieck J R JR Blaylock G G Dallapiccola C C Flood K T KT Hertzbach S S SS Kofler R R Moore T B TB Staengle H H Willocq S S Brau B B Cowan R R Sciolla G G Taylor F F Yamamoto R K RK Milek M M Patel P M PM Trischuk J J Lanni F F Palombo F F Bauer J M JM Booke M M Cremaldi L L Eschenburg V V Kroeger R R Reidy J J Sanders D A DA Summers D J DJ Martin J P JP Nief J Y JY Seitz R R Taras P P Zacek V V Nicholson H H Sutton C S CS Cartaro C C Cavallo N N De Nardo G G Fabozzi F F Gatto C C Lista L L Paolucci P P Piccolo D D Sciacca C C LoSecco J M JM Alsmiller J R G JR Gabriel T A TA Handler T T Brau J J Frey R R Iwasaki M M Sinev N B NB Strom D D Colecchia F F Dal Corso F F Dorigo A A Galeazzi F F Margoni M M Michelon G G Morandin M M Posocco M M Rotondo M M Simonetto F F Stroili R R Torassa E E Voci C C Benayoun M M Briand H H Chauveau J J David P P de La Vaissière Ch Ch Del Buono L L Hamon O O Le Diberder F F Leruste Ph P Lory J J Roos L L Stark J J Versillé S S Manfredi P F PF Re V V Speziali V V Frank E D ED Gladney L L Guo Q H QH Panetta J H JH Angelini C C Batignani G G Bettarini S S Bondioli M M Carpinelli M M Forti F F Giorgi M A MA Lusiani A A Martinez-Vidal F F Morganti M M Neri N N Paoloni E E Rama M M Rizzo G G Sandrelli F F Simi G G Triggiani G G Walsh J J Haire M M Judd D D Paick K K Turnbull L L Wagoner D E DE Albert J J Bula C C Elmer P P Lu C C McDonald K T KT Miftakov V V Schaffner S F SF Smith A J S AJ Tumanov A A Varnes E W EW Cavoto G G del Re D D Faccini R R Ferrarotto F F Ferroni F F Fratini K K Lamanna E E Leonardi E E Mazzoni M A MA Morganti S S Piredda G G Safai Tehrani F F Serra M M Voena C C Christ S S Waldi R R Adye T T Franek B B Geddes N I NI Gopal G P GP Xella S M SM Aleksan R R De Domenico G G Emery S S Gaidot A A Ganzhur S F SF Giraud P-F PF Hamel Monchenault G G Kozanecki W W Langer M M London G W GW Mayer B B Serfass B B Vasseur G G Yèche Ch Ch Zito M M Copty N N Purohit M V MV Singh H H Yumiceva F X FX Adam I I Anthony P L PL Aston D D Baird K K Berger J P JP Bloom E E Boyarski A M AM Bulos F F Calderini G G Claus R R Convery M R MR Coupal D P DP Coward D H DH Dorfan J J Doser M M Dunwoodie W W Field R C RC Glanzman T T Godfrey G L GL Gowdy S J SJ Grosso P P Himel T T Hryn'ova T T Huffer M E ME Innes W R WR Jessop C P CP Kelsey M H MH Kim P P Kocian M L ML Langenegger U U Leith D W G S DW Luitz S S Luth V V Lynch H L HL Marsiske H H Menke S S Messner R R Moffeit K C KC Mount R R Muller D R DR O'Grady C P CP Perl M M Petrak S S Quinn H H Ratcliff B N BN Robertson S H SH Rochester L S LS Roodman A A Schietinger T T Schindler R H RH Schwiening J J Seeman J T JT Serbo V V VV Snyder A A Soha A A Spanier S M SM Stelzer J J Su D D Sullivan M K MK Tanaka H A HA Va'vra J J Wagner S R SR Weinstein A J R AJ Wienands U U Wisniewski W J WJ Wright D H DH Young C C CC Burchat P R PR Cheng C H CH Kirkby D D Meyer T I TI Roat C C De Silva A A Henderson R R Bugg W W Cohn H H Weidemann A W AW Izen J M JM Kitayama I I Lou X C XC Turcotte M M Bianchi F F Bona M M Di Girolamo B B Gamba D D Smol A A Zanin D D Bosisio L L Della Ricca G G Lanceri L L Pompili A A Poropat P P Vuagnin G G Panvini R S RS Brown C M CM Kowalewski R R Roney J M JM Band H R HR Charles E E Dasu S S Di Lodovico F F Eichenbaum A M AM Hu H H Johnson J R JR Liu R R Nielsen J J Pan Y Y Prepost R R Scott I J IJ Sekula S J SJ von Wimmersperg-Toeller J H JH Wu S L SL Yu Z Z Zobernig H H Kordich T M B TM Neal H H BABAR Collaborations eng Journal Article 2002 02 26

United States Phys Rev Lett 0401141 0031-9007 11916658 2002 03 27 2002 04 15 2007 11 15

1070-910X 9 7 2002 Mar Harv Womens Health Watch By the way, doctor. A few months ago, I was surprised to read that a new study has raised a question about the value of screening mammograms. Is that true? I thought the importance of having such mammograms was well-established. I'm 52 and have been getting annual mammograms for 10 years. Should I stop? 8 Robb-Nicholson Celeste C eng Journal Article

United States Harv Womens Health Watch 9423147 1070-910X K Breast Neoplasms mortality radiography Clinical Trials as Topic standards Female Humans Mammography Middle Aged Patient Education as Topic Research Design 11966386 2002 04 22 2002 05 02 2007 11 15

0098-7484 287 16 2002 Apr 24 JAMA The 2001 Bethesda System: terminology for reporting results of cervical cytology. 2114-9 The Bethesda 2001 Workshop was convened to evaluate and update the 1991 Bethesda System terminology for reporting the results of cervical cytology. A primary objective was to develop a new approach to broaden participation in the consensus process. Forum groups composed of 6 to 10 individuals were responsible for developing recommendations for discussion at the workshop. Each forum group included at least 1 cytopathologist, cytotechnologist, clinician, and international representative to ensure a broad range of views and interests. More than 400 cytopathologists, cytotechnologists, histopathologists, family practitioners, gynecologists, public health physicians, epidemiologists, patient advocates, and attorneys participated in the workshop, which was convened by the National Cancer Institute and cosponsored by 44 professional societies. More than 20 countries were represented. Literature review, expert opinion, and input from an Internet bulletin board were all considered in developing recommendations. The strength of evidence of the scientific data was considered of paramount importance. Bethesda 2001 was a year-long iterative review process. An Internet bulletin board was used for discussion of issues and drafts of recommendations. More than 1000 comments were posted to the bulletin board over the course of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to the public. Postworkshop recommendations were posted on the bulletin board for a last round of critical review prior to finalizing the terminology. Bethesda 2001 was developed with broad participation in the consensus process. The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology. EPN Room 2130, 6130 Executive Blvd, Bethesda, MD 20892, USA. ds87v@nih.gov Solomon Diane D Davey Diane D Kurman Robert R Moriarty Ann A O'Connor Dennis D Prey Marianne M Raab Stephen S Sherman Mark M Wilbur David D Wright Thomas T Jr Young Nancy N Forum Group Members Bethesda 2001 Workshop eng Consensus Development Conference Consensus Development Conference, NIH Guideline Journal Article Review

United States JAMA 7501160 0098-7484 AIM IM JAMA. 2002 Apr 24;287(16):2140-1 11966390 Cervical Intraepithelial Neoplasia classification pathology Female Humans Laboratories standards Quality Control Terminology as Topic Uterine Cervical Dysplasia classification pathology Uterine Cervical Neoplasms diagnosis pathology Vaginal Smears classification standards 28 11953811 2002 05 09 2002 05 24 2008 11 21

1432-2218 16 5 2002 May Surg Endosc Disruptive visions: surgeon responsibility during the era of change. 733-4 Satava R M RM eng Editorial

Germany Surg Endosc 8806653 0930-2794 IM Biomedical Technology Commerce trends Delivery of Health Care trends General Surgery standards trends Health Services Needs and Demand trends Humans 12038483 2002 05 30 2002 07 26 2008 11 21

0273-1177 26 12 2000 Adv Space Res Planetary protection issues for Mars sample acquisition flight projects. 1911-6 The planned NASA sample acquisition flight missions to Mars pose several interesting planetary protection issues. In addition to the usual forward contamination procedures for the adequate protection of Mars for the sake of future missions, there are reasons to ensure that the sample is not contaminated by terrestrial microbes from the acquisition mission. Recent recommendations by the Space Studies Board (SSB) of the National Research Council (United States), would indicate that the scientific integrity of the sample is a planetary protection concern (SSB, 1997). Also, as a practical matter, a contaminated sample would interfere with the process for its release from quarantine after return for distribution to the interested scientists. These matters are discussed in terms of the first planned acquisition mission. c2001 COSPAR Published by Elsevier Science Ltd. All rights reserved. Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA. Barengoltz J B JB eng Journal Article Research Support, U.S. Gov't, Non-P.H.S.

United States Adv Space Res 9878935 0273-1177 7722-84-1 Hydrogen Peroxide S Containment of Biohazards Environmental Microbiology Extraterrestrial Environment Hot Temperature Hydrogen Peroxide Mars Space Flight standards Spacecraft Specimen Handling Sterilization methods United States United States National Aeronautics and Space Administration standards 00027913 NASA Center JPL NASA Discipline Exobiology Barengoltz J B JB JPL 12101218 2002 07 08 2002 08 12 2006 11 15

0021-9258 277 28 2002 Jul 12 J. Biol. Chem. Interaction between FtsZ and FtsW of Mycobacterium tuberculosis. 24983-7 The recruitment of FtsZ to the septum and its subsequent interaction with other cell division proteins in a spatially and temporally controlled manner are the keys to bacterial cell division. In the present study, we have tested the hypothesis that FtsZ and FtsW of Mycobacterium tuberculosis could be binding partners. Using gel renaturation, pull-down, and solid-phase assays, we confirm that FtsZ and FtsW interact through their C-terminal tails, which carry extensions absent in their Escherichia coli counterparts. Crucial to these interactions is the cluster of aspartate residues Asp(367) to Asp(370) of FtsZ, which most likely interact with a cluster of positively charged residues in the C-terminal tail of FtsW. Mutations of the aspartate residues 367-370 showed that changing three aspartate residues to alanine resulted in complete loss of interaction. This is the first demonstration of the direct interaction between FtsZ and FtsW. We speculate that this interaction between FtsZ and FtsW could serve to anchor FtsZ to the membrane and link septum formation to peptidoglycan synthesis in M. tuberculosis. The findings assume particular significance in view of the global efforts to explore new targets in M. tuberculosis for chemotherapeutic intervention. Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata 700009, India. Datta Pratik P Dasgupta Arunava A Bhakta Sanjib S Basu Joyoti J eng Journal Article Research Support, Non-U.S. Gov't 2002 05 06

United States J Biol Chem 2985121R 0021-9258 0 Bacterial Proteins 0 Cytoskeletal Proteins 0 DNA Primers 0 FtsZ protein, Bacteria 0 Membrane Proteins 125724-13-2 FtsW protein, Bacteria IM Amino Acid Sequence Bacterial Proteins chemistry metabolism Base Sequence Cytoskeletal Proteins DNA Primers Membrane Proteins Molecular Sequence Data Mycobacterium tuberculosis metabolism Protein Binding 12145319 2002 07 29 2002 09 16 2005 11 17

0021-9258 277 31 2002 Aug 2 J. Biol. Chem. Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly. 28271-9 The regulation of SNARE complex assembly likely plays an important role in governing the specificity as well as the timing of membrane fusion. Here we identify a novel brain-enriched protein, amisyn, with a tomosyn- and VAMP-like coiled-coil-forming domain that binds specifically to syntaxin 1a and syntaxin 4 both in vitro and in vivo, as assessed by co-immunoprecipitation from rat brain. Amisyn is mostly cytosolic, but a fraction co-sediments with membranes. The amisyn coil domain can form SNARE complexes of greater thermostability than can VAMP2 with syntaxin 1a and SNAP-25 in vitro, but it lacks a transmembrane anchor and so cannot act as a v-SNARE in this complex. The amisyn coil domain prevents the SNAP-25 C-terminally mediated rescue of botulinum neurotoxin E inhibition of norepinephrine exocytosis in permeabilized PC12 cells to a greater extent than it prevents the regular exocytosis of these vesicles. We propose that amisyn forms nonfusogenic complexes with syntaxin 1a and SNAP-25, holding them in a conformation ready for VAMP2 to replace it to mediate the membrane fusion event, thereby contributing to the regulation of SNARE complex formation. Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305-5345, USA. Scales Suzie J SJ Hesser Boris A BA Masuda Esteban S ES Scheller Richard H RH eng GENBANK AF391153 Journal Article 2002 05 24

United States J Biol Chem 2985121R 0021-9258 0 Carrier Proteins 0 Membrane Proteins 0 Nerve Tissue Proteins 0 Qa-SNARE Proteins 0 Recombinant Fusion Proteins 0 SNAP25 protein, human 0 SNARE Proteins 0 STX1A protein, human 0 STXBP6 protein, human 0 Snap25 protein, rat 0 Stx1a protein, rat 0 Synaptosomal-Associated Protein 25 0 Syntaxin 1 0 Vesicular Transport Proteins 51-41-2 Norepinephrine EC 2.5.1.18 Glutathione Transferase IM Amino Acid Sequence Animals Binding Sites Carrier Proteins chemistry genetics physiology Exocytosis Glutathione Transferase genetics HeLa Cells Humans Kinetics Membrane Proteins chemistry metabolism physiology Molecular Sequence Data Nerve Tissue Proteins chemistry metabolism Norepinephrine antagonists & inhibitors secretion PC12 Cells Pheochromocytoma Protein Structure, Secondary Qa-SNARE Proteins Rats Recombinant Fusion Proteins metabolism SNARE Proteins Sequence Alignment Sequence Homology, Amino Acid Synaptosomal-Associated Protein 25 Syntaxin 1 Thermodynamics Vesicular Transport Proteins 12159900 2002 08 03 2002 08 22 2007 11 15

0362-4331 2002 Jul 2 NY Times (Print) Weighing medical ethics for many years to come: a conversation with Harold Shapiro. Interview by Howard Markel. F6 Shapiro Harold H eng Interview Newspaper Article

United States NY Times (Print) 9877126 0362-4331 E Advisory Committees Bioethical Issues Biomedical Research Biotechnology Cloning, Organism Conflict of Interest Embryo Research Embryo, Mammalian cytology Financing, Government Health Priorities Human Experimentation Humans Research Support as Topic Stem Cells United States 103061 VF 2.1 Bioethics and Professional Ethics National Bioethics Advisory Commission Popular Approach/Source KIE Bib: bioethics 12174865 2002 08 13 2002 08 21 2004 11 17

1145-0762 11 2 2000 Jun J Int Bioethique Physicians' attitudes towards medical ethics issues in Turkey. 57-67 Dept. of Deontology, Faculty of Medicine, University of Ankara, Tip. Fak. Dekanligi, Morfoloji Terleskesi, Anakara, Sihhiye - 06100 Turkey. Pelin S S SS Arda B B eng Journal Article

France J Int Bioethique 9015754 1145-0762 E Abortion, Induced Animal Experimentation Animals Attitude of Health Personnel Bioethical Issues Biomedical Research Complementary Therapies Confidentiality Data Collection Ethics, Medical Ethics, Research Euthanasia Humans Physician-Patient Relations Physicians psychology Prejudice Reproductive Techniques, Assisted Truth Disclosure Turkey 102894 Bioethics and Professional Ethics Empirical Approach Pelin, Serap Sahinoglu; Arda, Berna KIE Bib: bioethics; medical ethics 12192682 2002 08 22 2002 09 09 2006 11 15

0018-9251 35 3 1999 Jul IEEE Trans Aerosp Electron Syst Intelligent control of a planning system for astronaut training. 1055-70 This work intends to design, analyze and solve, from the systems control perspective, a complex, dynamic, and multiconstrained planning system for generating training plans for crew members of the NASA-led International Space Station. Various intelligent planning systems have been developed within the framework of artificial intelligence. These planning systems generally lack a rigorous mathematical formalism to allow a reliable and flexible methodology for their design, modeling, and performance analysis in a dynamical, time-critical, and multiconstrained environment. Formulating the planning problem in the domain of discrete-event systems under a unified framework such that it can be modeled, designed, and analyzed as a control system will provide a self-contained theory for such planning systems. This will also provide a means to certify various planning systems for operations in the dynamical and complex environments in space. The work presented here completes the design, development, and analysis of an intricate, large-scale, and representative mathematical formulation for intelligent control of a real planning system for Space Station crew training. This planning system has been tested and used at NASA-Johnson Space Center. Johnson Space Center, USA. Ortiz J J Chen G G eng Journal Article Research Support, U.S. Gov't, Non-P.H.S.

United States IEEE Trans Aerosp Electron Syst 9876802 0018-9251 S Algorithms Artificial Intelligence Astronauts education Humans Inservice Training Space Flight education Spacecraft Systems Analysis Time Management United States United States National Aeronautics and Space Administration 00028138 Grant numbers: DAAG55-98-1-0198. 12211241 2002 09 03 2002 09 13 2007 03 19

1095-9203 297 5586 2002 Aug 30 Science Mycobacterium leprae and demyelination. 1475-6; author reply 1475-6 Ottenhoff Tom H M TH eng Comment Letter

United States Science 0404511 0036-8075 IM Science. 2002 May 3;296(5569):927-31 11988579 Bacterial Adhesion Demyelinating Diseases immunology microbiology pathology Humans Leprosy immunology microbiology pathology Mycobacterium leprae pathogenicity physiology Schwann Cells microbiology 12211266 2002 09 03 2002 09 25 2004 11 17

1054-6863 12 1 2002 Mar Kennedy Inst Ethics J Public policy and the sale of human organs. 47-64 Gill and Sade, in the preceding article in this issue of the Kennedy Institute of Ethics Journal, argue that living individuals should be free from legal constraints against selling their organs. The present commentary responds to several of their claims. It explains why an analogy between kidneys and blood fails; why, as a matter of public policy, we prohibit the sale of human solid organs, yet allow the sale of blood; and why their attack on Kant's putative argument against the sale of human body parts is misplaced. Finally, it rejects the claim that the state is entitled to interfere with the actions of individuals only if such actions would harm others. We draw certain lines grounded in what Rawls has termed "public reason" beyond which we do not give effect to the autonomous self-regarding decisions of individuals. Public resistance to the sale of human body parts, no matter how voluntary or well informed, is grounded in the conviction that such a practice would diminish human dignity and our sense of solidarity. A system of organ donation, in contrast, conveys our respect for persons and honors our common humanity. Kennedy Institute of Ethics, Georgetown University, Washington, DC, USA. Cohen Cynthia B CB eng Journal Article

United States Kennedy Inst Ethics J 9109135 1054-6863 E Blood Donors Commodification Ethical Analysis Fees and Charges Human Body Humans Kidney Kidney Transplantation economics Living Donors Public Policy Tissue and Organ Procurement economics United States 103573 Analytical Approach Health Care and Public Health 24 refs. 4 fn. KIE Bib: blood donation; organ and tissue donation 12219757 2002 09 09 2002 09 13 2006 09 26

1225-505X 10 1 2001 Jun Uisahak Development of neurophysiology in the early twentieth century: Charles Scott Sherrington and The Integrative action of the nervous system. 1-21 Department of the Medical History and Medical Humanities, Seoul National University College of Medicine. Kim O J OJ eng Biography Historical Article Journal Article

Korea (South) Uisahak 9605018 1225-505X Q Books history Great Britain History, 19th Century History, 20th Century Neurophysiology history Sherrington C S CS 12227380 2002 09 12 2002 09 13 2004 11 17

0269-8897 15 1 2002 Mar Sci Context Paracelsus, Paracelsianism, and the secularization of the worldview. 9-27 This paper examines Paracelsus and Paracelsianism in the light of the ideas of Max Weber concerning the social consequences of the Reformation, with special reference to his theories of Entzauberung and secularization. He linked these tendencies both to the rise of capitalism and the growth of experimental science. The detailed case study of Paracelsus' account of diseases linked with saints, in common with his interpretation of many other conditions, demonstrates that he self-consciously extended the boundaries of medicine and eroded the role of magic and witchcraft associated with the church. On the other hand, Paracelsus adopted the Neoplatonic worldview, was immersed in popular magic, and evolved a system of medicine that self-consciously revolved around magic. These factors seem to place a distinct limit on his role in the demystification of knowledge. However, the magic of Paracelsus entailed a decisive break with the entrenched elitist and esoteric tradition of the occultists and hermeticists. It is argued that this reconstructed magic re-establishes the credentials of Paracelsus as a significant contributor to the disenchantment and secularization of the worldview. All Souls College, Oxford. Webster Charles C eng Biography Historical Article Journal Article

England Sci Context 8904113 0269-8897 Q Europe History, 17th Century History, 20th Century History, Early Modern 1451-1600 Magic history Medicine Philosophy history Religion and Medicine Sciatica history Paracelsus Weber Max M 12230355 2002 09 16 2002 09 25 2005 11 17

1539-3704 137 6 2002 Sep 17 Ann. Intern. Med. Screening for osteoporosis in postmenopausal women: recommendations and rationale. 526-8 U.S. Preventive Services Task Force eng Guideline Journal Article Practice Guideline

United States Ann Intern Med 0372351 0003-4819 AIM IM Ann Intern Med. 2003 Apr 15;138(8):689; author reply 389-90 12693905 Ann Intern Med. 2002 Sep 17;137(6):I59 12230384 Age Factors Aged Female Fractures, Bone etiology prevention & control Humans Mass Screening Middle Aged Osteoporosis, Postmenopausal complications diagnosis Risk Factors 12230384 2002 09 16 2002 09 25 2005 11 17

1539-3704 137 6 2002 Sep 17 Ann. Intern. Med. Summaries for patients. Screening for osteoporosis: recommendations from the U.S. Preventive Services Task Force. I59 eng Journal Article Patient Education Handout

United States Ann Intern Med 0372351 0003-4819 AIM IM Ann Intern Med. 2002 Sep 17;137(6):526-8 12230355 Ann Intern Med. 2002 Sep 17;137(6):529-41 12230356 Aged Bone Density Evidence-Based Medicine Female Fractures, Bone etiology prevention & control Humans Mass Screening Middle Aged Osteoporosis, Postmenopausal complications diagnosis therapy Risk Factors United States 12369570 2002 10 07 2003 02 21 2008 11 21

8750-7587 93 4 2002 Oct J. Appl. Physiol. Human unilateral lower limb suspension as a model for spaceflight effects on skeletal muscle. 1563-5; author reply 1565-6 Adams Gregory R GR eng Comment Letter

United States J Appl Physiol 8502536 0161-7567 IM S J Appl Physiol. 2002 Jul;93(1):354-60 12070225 Bed Rest Humans Immobilization Leg Muscle Fibers, Skeletal physiology Muscle, Skeletal physiology Space Flight Weight-Bearing NASA Discipline Musculoskeletal Non-NASA Center Flight Experiment STS-78 Shuttle Project manned short duration Adams G R GR U CA, Irvine Fitts R H RH Vanderbilt U, Nashville, TN 12416895 2002 11 05 2003 04 01 2007 11 14

1528-9117 8 5 2002 Sep-Oct Cancer J Radiotherapy alone for lymphocyte-predominant Hodgkin's disease. 377-83 The purpose of the study was to analyze the results with radiotherapy alone in a select group of asymptomatic adults with nonbulky, early-stage lymphocyte-predominant Hodgkin's disease. Between 1963 and 1995, 36 patients with nonbulky stage IA (N = 27) or IIA (N = 9) supradiaphragmatic (N = 27) or subdiaphragmatic (N = 9) lymphocyte-predominant Hodgkin's disease were treated with radiotherapy alone. Eleven of the patients underwent laparotomy. Limited-field radiotherapy involving only one side of the diaphragm and extended-field radiotherapy encompassing both sides of the diaphragm were used in 28 and 8 cases, respectively. Median dose to involved areas was 40.0 Gy given daily in 20 2.0-Gy fractions. Salvage treatmentconsisted of MOPP (mechlorethamine, vincristine, prednisone, procarbazine), CVPP/ABDIC (cyclophosphamide, vinblastine, procarbazine and prednisone/doxorubicin, bleomycin, dacarbazine, lomustine, and prednisone), or ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy and/or involved-field radiotherapy. Median follow-up was 8.8 years (range, 3.0-34.4 years). None of the 15 patients with supradiaphragmatic disease who received limited-field radiotherapy to regions that did not include the mediastinal or hilar nodes subsequently experienced relapse there. Only one of 20 patients who received supradiaphragmatic limited-field radiotherapy alone experienced relapse in the paraaortic nodes or spleen. The 5-year relapse-free and overall survival rates for the 20 patients with stage IA lymphocyte-predominant Hodgkin's disease treated with involved-field or regional radiotherapy were 95% and 100%, respectively. There were no cases of severe or life-threatening cardiac toxicity. No solid tumors have been observed in-field in patients treated with limited-field radiotherapy, even though they have been followed up longer than those treated with extended-field radiotherapy (median follow-up, 11.6 vs 5.5 years); two solid tumors have developed in-field in patients who received extended-field radiotherapy. Involved-field or regional radiotherapy alone may be adequate in stage IA lymphocyte-predominant Hodgkin's disease patients. Longer follow-up will help to more clearly define the risks of cardiac toxicity and solid tumors that result from involved-field or regional radiotherapy, which appear to be low based on follow-up to date. Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston 77030-4009, USA. Schlembach Pamela J PJ Wilder Richard B RB Jones Dan D Ha Chul S CS Fayad Luis E LE Younes Anas A Hagemeister Fredrick F Hess Mark M Cabanillas Fernando F Cox James D JD eng CA 16672 CA NCI NIH HHS United States CA 6294 CA NCI NIH HHS United States Journal Article Research Support, U.S. Gov't, P.H.S.

United States Cancer J 100931981 1528-9117 11056-06-7 Bleomycin 13010-47-4 Lomustine 23214-92-8 Doxorubicin 4342-03-4 Dacarbazine 51-75-2 Mechlorethamine 53-03-2 Prednisone 57-22-7 Vincristine 671-16-9 Procarbazine 865-21-4 Vinblastine ABDIC protocol ABVD protocol CVPP protocol MOPP protocol IM Cancer J. 2002 Sep-Oct;8(5):367-8 12416892 Adolescent Adult Antineoplastic Combined Chemotherapy Protocols administration & dosage therapeutic use Bleomycin administration & dosage Combined Modality Therapy Dacarbazine administration & dosage Doxorubicin administration & dosage Female Hodgkin Disease drug therapy radiotherapy Humans Lomustine administration & dosage Male Mechlorethamine administration & dosage Middle Aged Prednisone administration & dosage Procarbazine administration & dosage Radiotherapy Dosage Retrospective Studies Salvage Therapy methods Survival Analysis Treatment Outcome Vinblastine administration & dosage Vincristine administration & dosage 12501715 2002 12 27 2003 01 08 2005 11 16

0559-7765 29 1 1998 Jan Sheng Li Ke Xue Jin Zhan [Mechanism of bone mineral loss in microgravity]. 84-6 Cui W W chi Journal Article Review

China Sheng Li Ke Xue Jin Zhan 20730140R 0559-7765 IM S Bone Demineralization, Pathologic etiology Humans Space Flight Weightlessness adverse effects Weightlessness Simulation adverse effects 10 Cosmos 1129 Project Cosmos 2044 Project Flight Experiment STS-51B Shuttle Project STS-54 Shuttle Project manned short duration unmanned 12599353 2003 02 24 2003 03 10 2007 11 15

0025-4282 53 4 1994 MD Law Rev The new Uniform Health Care Decisions Act: paving a health care decisions superhighway? 1238-54 American Bar Association, Commission on Legal Problems of the Elderly, USA. Sabatino C P CP eng Journal Article

United States MD Law Rev 100971842 0025-4282 E Advance Directives legislation & jurisprudence Decision Making Humans Legislation, Medical Life Support Care Personal Autonomy Proxy legislation & jurisprudence Records as Topic United States 106309 Special Issue Death and Euthanasia Legal Approach Uniform Health-Care Decisions Act Uniform Rights of the Terminally Ill Act Sabatino, Charles P 102 fn. KIE Bib: advance directives 12599354 2003 02 24 2003 03 10 2004 11 17

0025-4282 53 4 1994 MD Law Rev The right to refuse life-sustaining medical treatment: national trend and recent changes in Maryland law. 1306-43 Goldmeier K E KE eng Journal Article

United States MD Law Rev 100971842 0025-4282 E Decision Making Euthanasia, Passive legislation & jurisprudence Family psychology Humans Legal Guardians legislation & jurisprudence Life Support Care Maryland Persistent Vegetative State Right to Die legislation & jurisprudence Treatment Refusal legislation & jurisprudence United States 106310 Special Issue Death and Euthanasia Legal Approach Mack v. Mack Goldmeier, Karen E 235 fn. KIE Bib: allowing to die/legal aspects; treatment refusal 12742516 2003 05 13 2009 02 27

1879-0712 468 2 2003 May 9 Eur. J. Pharmacol. S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. 93-101 Mitochondrial Ca(2+) accumulation can induce a sudden increase in the permeability of the inner membrane. This phenomenon is due to the generation of a large nonselective ion channel, termed the permeability transition pore (PTP), which contributes to cellular injury during ischemia and reperfusion. Inhibition of PTP generation constitutes a relevant pharmacological target to protect a cell from death. In this study, we examined the effect of S-15176 ((N-[(3,5-di-tertiobutyl-4-hydroxy-1-thiophenyl)]-3-propyl-N'-(2,3,4-trimethoxybenzyl)piperazine), a novel anti-ischemic agent, on PTP in rat liver mitochondria. S-15176 prevented PTP opening generated by various triggering agents, as attested by the concentration-dependent inhibition of mitochondrial swelling, of mitochondrial membrane potential dissipation and of NADPH oxidation. These effects were associated with an increase in the Ca(2+) loading capacity of mitochondria. S-15176 was a strong inhibitor of lipid peroxidation, but experiments with another trimetazidine derivative devoid of antioxidant activity indicated that this activity was not essential to the inhibitory effect. Binding studies demonstrated that [3H]S-15176 bound to mitochondrial binding sites, especially those localized in the inner membrane. These sites were shared by several well-known inhibitors of PTP opening. These results demonstrate that the mechanism by which S-15176 protects mitochondria against the deleterious effects of ischemia-reperfusion involves inhibition of PTP opening and provide evidence that the drug operates through low structural specificity binding sites located in the inner mitochondrial membrane. Département de Pharmacologie, Faculté de Médecine de Paris XII, Créteil, France Elimadi Aziz A Jullien Vincent V Tillement Jean Paul JP Morin Didier D eng Journal Article Research Support, Non-U.S. Gov't

Netherlands Eur J Pharmacol 1254354 0014-2999 0 Antioxidants 0 Mitochondrial Membrane Transport Proteins 0 Piperazines 0 S 15176 0 mitochondrial permeability transition pore 53-59-8 NADP 7440-70-2 Calcium IM Animals Antioxidants pharmacology Binding Sites Calcium metabolism Lipid Peroxidation drug effects Male Membrane Potential, Mitochondrial drug effects Mitochondria, Liver drug effects metabolism Mitochondrial Membrane Transport Proteins drug effects metabolism NADP metabolism Oxidation-Reduction Piperazines pharmacology Rats Rats, Wistar 12742518 2003 05 13 2009 02 27

1879-0712 468 2 2003 May 9 Eur. J. Pharmacol. Behavioral effects of rimcazole analogues alone and in combination with cocaine. 109-19 Several sigma receptor ligands have been reported to also have affinity for the dopamine transporter, among them rimcazole (9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole dihydrochloride). However, rimcazole lacks behavioral effects like those of other dopamine uptake inhibitors, such as cocaine and GBR 12909 (1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride). Because of this profile, the interactions with cocaine of rimcazole and several of its novel analogues were assessed. The compounds studied were rimcazole, its N-methyl analogue, SH 1-73 (9-[3-(cis-3,5-dimethyl-4-methyl-1-piperazinyl)-propyl]carbazole hydrobromide), the dibrominated analogue, SH 1-76 (3,6-dibromo-9-[3-(cis-3,5-dimethyl-1-piperazinyl)-propyl]carbazole hydrochloride), and the N-propylphenyl analogues, SH 3-24 ([3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]diphenylamine hydrochloride) and SH 3-28 (9-[3-(cis-3,5-dimethyl-4-[3-phenylpropyl]-1-piperazinyl)-propyl]carbazole hydrobromide). The former has a diphenyl-amine group in place of the carbazole moiety of rimcazole, giving the compound additional structural similarity to GBR 12909. The rimcazole analogues produced dose-related decreases in locomotor activity, and also decreased cocaine-stimulated activity in mice. In rats trained to discriminate 10 mg/kg cocaine (i.p.) from saline injections, cocaine and GBR 12909 each produced a dose-related increase in cocaine-appropriate responding. Cocaine also increased rates of responding. SH 3-28 decreased cocaine-appropriate responding at the cocaine training dose to about 58% (SH 3-28) with two of five subjects selecting the cocaine response key. Neither rimcazole nor SH 3-24 produced a significant attenuation of the discriminative effects of cocaine. Rimcazole and its analogs all attenuated the increases in rates of responding produced by cocaine. In contrast to effects obtained with rimcazole analogs, GBR 12909 potentiated the cocaine-induced increases in locomotor activity and operant behavior, as well as the discriminative-stimulus effects of cocaine. The present results indicate that analogues of rimcazole can attenuate the behavioral effects of cocaine, and though the mechanism for these effects is not presently clear, it is possible that this attenuation maybe mediated by actions of the rimcazole analogues at the dopamine transporter and/or sigma receptors. Department of Health and Human Services, Medications Discovery Research Branch, NIDA Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. jkatz@intra.nida.nih.gov Katz Jonathan L JL Libby Therissa A TA Kopajtic Theresa T Husbands Stephen M SM Newman Amy Hauck AH eng Journal Article Research Support, N.I.H., Extramural

Netherlands Eur J Pharmacol 1254354 0014-2999 0 Carbazoles 0 Dopamine Plasma Membrane Transport Proteins 0 Dopamine Uptake Inhibitors 0 Receptors, sigma 50-36-2 Cocaine 75859-04-0 rimcazole IM Animals Behavior, Animal drug effects Carbazoles administration & dosage agonists pharmacology Cocaine administration & dosage pharmacology Conditioning, Operant drug effects Dopamine Plasma Membrane Transport Proteins drug effects metabolism Dopamine Uptake Inhibitors administration & dosage pharmacology Dose-Response Relationship, Drug Male Mice Motor Activity drug effects Rats Rats, Sprague-Dawley Receptors, sigma drug effects metabolism Structure-Activity Relationship 12742519 2003 05 13 2009 02 27 2010 11 18

1879-0712 468 2 2003 May 9 Eur. J. Pharmacol. Risperidone reduces limited access alcohol drinking in alcohol-preferring rats. 121-7 An atypical antipsychotic drug risperidone reduced ethanol drinking of ethanol-preferring Alko, Alcohol (AA) rats in a limited access paradigm. Its effect was transient at a dose known to preferentially antagonize the 5-HT(2) receptors (0.1 mg/kg, s.c.), but long-lasting when the dose was increased to 1.0 mg/kg that also blocks dopamine D(2) receptors. Risperidone also reduced dose-dependently locomotor activity and limited access saccharin intake of the AA rats, indicating that its effect on ethanol drinking was not selective. Risperidone at 0.1 mg/kg given before four successive daily ethanol-drinking sessions significantly reduced the ethanol intake. These data from an animal model of high ethanol intake suggest that risperidone should be tested in various populations of alcoholics for reducing ethanol consumption. Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland Ingman Kimmo K Honkanen Aapo A Hyytiä Petri P Huttunen Matti O MO Korpi Esa R ER eng Journal Article Research Support, Non-U.S. Gov't

Netherlands Eur J Pharmacol 1254354 0014-2999 0 Antipsychotic Agents 0 Receptors, Dopamine D2 0 Serotonin 5-HT2 Receptor Antagonists 106266-06-2 Risperidone 81-07-2 Saccharin IM Alcohol Drinking prevention & control Alcoholism drug therapy Animals Antipsychotic Agents administration & dosage pharmacology Disease Models, Animal Dose-Response Relationship, Drug Male Motor Activity drug effects Rats Receptors, Dopamine D2 antagonists & inhibitors Risperidone administration & dosage pharmacology Saccharin Self Administration Serotonin 5-HT2 Receptor Antagonists 14594616 2003 11 03 2004 02 02 2004 11 17

1087-2108 9 4 2003 Oct Dermatol. Online J. Epidermal nevus. 43 A 20-year-old woman presented with an asymptomatic, life-long, verrucous, hyperpigmented plaque on the face and neck that corresponded to the lines of Blaschko. Histopathologic examination shows an epidermal nevus. This nevus presents a challenge in management because of the location and extent of the lesion. Ronald O. Perelman Department of Dermatology, New York University, USA. Cassetty Christopher T CT Leonard Aimee L AL eng Case Reports Journal Article

United States Dermatol Online J 9610776 1087-2108 IM Adult Facial Neoplasms pathology therapy Female Humans Nevus pathology therapy Skin Neoplasms pathology therapy 14668029 2003 12 11

1024-5332 8 6 2003 Dec Hematology Clopidogrel: Interactions with the P2Y12 Receptor and Clinical Relevance. 359-65 Dorsam Robert T RT Murugappan Swaminathan S Ding Zhongren Z Kunapuli Satya P SP eng Journal Article

England Hematology 9708388 1024-5332 IM 14668030 2003 12 11

1024-5332 8 6 2003 Dec Hematology Platelet counts and interleukin-6 (IL-6) promoter polymorphism in patients with Gaucher disease. 367-8 Elstein Deborah D Altarescu Gheona G Zimran Ari A eng Journal Article

England Hematology 9708388 1024-5332 IM 14695699 2003 12 26 2005 04 12 2006 11 15

1226-0479 9 4 2003 Dec Taehan Kan Hakhoe Chi [The significance of urine sodium measurement after furosemide administration in diuretics-unresponsive patients with liver cirrhosis]. 324-31 The diagnosis of refractory ascites means a poor prognosis for patients with liver cirrhosis. The definition of refractory ascites has already been established, but using the dosage of diuretics that correlates with the definition of refractory ascites in an out-patient department will lower the compliance of the patient, as well as causing serious complications, such as hepatic encephalopathy and hyponatremia, as the dosage of diuretics is increased. Due to this fact, it is very difficult to apply this definition of refractory ascites to patients in a domestic out-patient department. In this study, in situations where there are difficulties in applying the diuretics dosage according to definition of refractory ascites, we tried to find out whether measuring the value of urine sodium after the administration of intravenous furosemide can be the standard in early differentiation of the response to diuretics treatment. We reviewed 16 cases of liver cirrhosis with ascites and classified them into two groups by the response to diuretics. The diuretics-responsive ascites group was 8 cases and the diuretics-unresponsive ascites group consisted of 8 cases. After admission, we examined the patients' CBC, biochemical liver function test, spot urine sodium, and 24 hour creatinine clearance. After the beginning of the experiment, all diuretic therapy was stopped for 3 days. Daily we examined the patients' CBC, biochemical liver function test, and in the 3rd experiment day, we measured 24-hour urine volume and sodium. In the 4th experiment day, after sampling for ADH, plasma renin activity and plasma aldosterone level, we administrated the furosemide 80 mg I.V, and measured the amount of 8 hour urine volume and sodium. The plasma aldosterone level was significantly higher in the diuretics- unresponsive ascites group than in the diuretics-responsive ascites group. In the 4th experiment day, the amount of urine volume and sodium was very significantly lower in the diuretics-unresponsive ascites group than in the diuretics-responsive ascites group (1297.5 +/-80.9 vs 2003.7 +/-114.6 ml, p<0.005, 77.3 +/-8.2 vs 211.8 +/-12.6 mEq, p<0.001). In out-patient departments, the measurement of urine sodium 8 hours after administrating 80 mg of intravenous furosemide, will help in differentiating ascites patients with lower treatment response to diuretics. Research Institute of Digestive Disease, Hanyang University College of Medicine, Seoul, Korea. Cho Hyun Seok HS Park Geun Tae GT Kim Young Hoon YH Shim Sung Gon SG Kim Jin Bae JB Lee Oh Young OY Choi Ho Soon HS Hahm Joon Soo JS Lee Min Ho MH kor English Abstract Journal Article

Korea (South) Taehan Kan Hakhoe Chi 9607534 1226-0479 0 Diuretics 54-31-9 Furosemide 7440-23-5 Sodium IM Adult Aged Ascites drug therapy etiology urine Diuretics administration & dosage Female Furosemide administration & dosage Humans Infusions, Intravenous Liver Cirrhosis complications Male Middle Aged Sodium urine 14729922 2004 01 19 2004 02 11 2009 11 18

1362-4962 32 1 2004 Nucleic Acids Res. Local homology recognition and distance measures in linear time using compressed amino acid alphabets. 380-5 Methods for discovery of local similarities and estimation of evolutionary distance by identifying k-mers (contiguous subsequences of length k) common to two sequences are described. Given unaligned sequences of length L, these methods have O(L) time complexity. The ability of compressed amino acid alphabets to extend these techniques to distantly related proteins was investigated. The performance of these algorithms was evaluated for different alphabets and choices of k using a test set of 1848 pairs of structurally alignable sequences selected from the FSSP database. Distance measures derived from k-mer counting were found to correlate well with percentage identity derived from sequence alignments. Compressed alphabets were seen to improve performance in local similarity discovery, but no evidence was found of improvements when applied to distance estimates. The performance of our local similarity discovery method was compared with the fast Fourier transform (FFT) used in MAFFT, which has O(L log L) time complexity. The method for achieving comparable coverage to FFT is revealed here, and is more than an order of magnitude faster. We suggest using k-mer distance for fast, approximate phylogenetic tree construction, and show that a speed improvement of more than three orders of magnitude can be achieved relative to standard distance methods, which require alignments. bob@drive5.com Edgar Robert C RC eng Journal Article 2004 01 16

England Nucleic Acids Res 0411011 0305-1048 0 Amino Acids 0 Proteins IM Proteins. 2000 Feb 1;38(2):149-64 10656262 J Mol Biol. 2003 Feb 7;326(1):317-36 12547212 Mol Biol Evol. 2002 Jan;19(1):8-13 11752185 Nucleic Acids Res. 2002 Jul 15;30(14):3059-66 12136088 Nucleic Acids Res. 1998 Jan 1;26(1):316-9 9399863 Bioinformatics. 2003 Mar 1;19(4):513-23 12611807 Protein Eng. 2003 May;16(5):323-30 12826723 Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10915-9 1438297 Comput Appl Biosci. 1992 Jun;8(3):275-82 1633570 J Mol Biol. 1991 Jun 5;219(3):555-65 2051488 J Mol Biol. 1990 Oct 5;215(3):403-10 2231712 Proc Natl Acad Sci U S A. 1988 Apr;85(8):2444-8 3162770 Mol Biol Evol. 1987 Jul;4(4):406-25 3447015 J Theor Biol. 1986 Mar 21;119(2):205-18 3461222 Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 7984417 Proc Int Conf Intell Syst Mol Biol. 1996;4:230-40 8877523 Protein Eng. 2000 Mar;13(3):149-52 10775656 Algorithms Amino Acids analysis Computational Biology methods Evolution, Molecular Molecular Sequence Data Phylogeny Proteins chemistry Sequence Alignment methods Sequence Homology, Amino Acid Software Time Factors PMC373290 14744982 2004 01 27 2004 02 02 2009 11 18

1362-4962 32 1 2004 Nucleic Acids Res. Superior 5' homogeneity of RNA from ATP-initiated transcription under the T7 phi 2.5 promoter. e14 Transcription from the commonly used GTP- initiating T7 class III promoter phi6.5 frequently produces heterogeneous RNA at both 3' and 5' ends. We demonstrate here that RNA transcripts from the T7 class II promoter phi2.5 have superior 5' homogeneity over those from the phi6.5 promoter, with comparable total RNA yields. The overall homogeneity of RNA transcripts is improved to different degrees depending on RNA sequences, although transcription under phi2.5 does not affect the 3' heterogeneity of RNA. In combination with 3' RNA trimming by DNAzymes or ribozymes, this ATP- initiated transcription system based on the T7 phi2.5 promoter can provide excellent quality of RNA for applications requiring a high degree of RNA size homogeneity. Department of Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS 39406-5043, USA. Coleman Tricia M TM Wang Guocan G Huang Faqing F eng Journal Article Research Support, U.S. Gov't, Non-P.H.S. 2004 01 15

England Nucleic Acids Res 0411011 0305-1048 0 3' Untranslated Regions 0 5' Untranslated Regions 0 RNA, Viral 56-65-5 Adenosine Triphosphate IM RNA. 1999 May;5(5):618-21 10334331 RNA. 1999 Sep;5(9):1268-72 10496227 Curr Opin Struct Biol. 2000 Jun;10(3):298-302 10851189 Biochemistry. 2000 Dec 19;39(50):15548-55 11112541 Methods. 2001 Mar;23(3):201-5 11243833 Nucleic Acids Res. 2002 Jun 15;30(12):e56 12060694 Chem Biol. 2002 Nov;9(11):1227-36 12445773 Methods Enzymol. 1995;261:350-80 8569503 Methods Enzymol. 1995;261:300-22 8569501 Nature. 1994 Nov 3;372(6501):68-74 7969422 Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3680-4 7682716 J Mol Biol. 1995 Jun 2;249(2):398-408 7540213 Science. 1998 Oct 9;282(5387):259-64 9841391 RNA. 1998 Oct;4(10):1313-7 9769105 Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4262-6 9113977 Science. 1996 Sep 20;273(5282):1678-85 8781224 Nucleic Acids Res. 1996 Mar 1;24(5):977-8 8600468 Nucleic Acids Res. 2003 Feb 1;31(3):e8 12560511 Nucleic Acids Res. 2003 Aug 1;31(15):e82 12888534 Nature. 1992 Jan 9;355(6356):184-6 1370345 Nucleic Acids Res. 1992 Sep 11;20(17):4515-23 1383928 RNA. 2003 Dec;9(12):1562-70 14624011 J Biol Chem. 1988 Dec 5;263(34):18123-7 3192528 Nucleic Acids Res. 1987 Nov 11;15(21):8783-98 3684574 J Mol Biol. 1983 Jun 5;166(4):477-535 6864790 3' Untranslated Regions genetics metabolism 5' Untranslated Regions genetics metabolism Adenosine Triphosphate metabolism pharmacology Bacteriophage T7 genetics Base Sequence Gene Expression Regulation, Viral Molecular Sequence Data Molecular Weight Promoter Regions, Genetic genetics RNA, Viral chemistry genetics metabolism Transcription, Genetic drug effects PMC373309 14749521 2004 01 29 2004 02 23 2004 11 17

1539-6150 2004 4 2004 Jan 28 Sci Aging Knowledge Environ Hampering a heartbreaker. Antibiotic might stem injury from heart attack. nf13 A TV ad urges people who think they're having a heart attack to pop an aspirin before rushing to the emergency room. They might be even better off taking antibiotics, according to a new study. The work shows that an antibiotic stems a previously untreatable form of heart damage not by killing bugs but by suppressing cellular enzymes. Leslie Mitch M eng News 2004 01 28

United States Sci Aging Knowledge Environ 101146039 1539-6150 0 Enzyme Inhibitors 56-75-7 Chloramphenicol IM Animals Chloramphenicol therapeutic use Enzyme Inhibitors therapeutic use Humans Myocardial Infarction enzymology prevention & control Myocardial Ischemia enzymology prevention & control Myocardial Reperfusion Injury enzymology prevention & control Rats 14991249 2004 04 16 2005 03 15

0364-2348 33 5 2004 May Skeletal Radiol. Spontaneous resolution of solitary osteochondroma in the young adult. 303-5 Spontaneous resolution of a solitary osteochondroma is rare. Such a case is presented in a patient nearing skeletal maturity. Based on a search of the English literature this is the first such report in a patient of this age. Department of Orthopaedics, Queen Alexandra Hospital, Portsmouth, UK. Reston S C SC Savva N N Richards R H RH eng Case Reports Journal Article 2004 02 26

Germany Skeletal Radiol 7701953 0364-2348 IM Adolescent Bone Neoplasms diagnosis Femur radiography Follow-Up Studies Humans Male Osteochondroma diagnosis Remission, Spontaneous 11431089 2004 04 20 2005 06 08

0924-7947 7 2001 Arch Gerontol Geriatr Suppl An investigation on behavioral problems in centenarians. 375-8 Department of Aging Science, Policlinico Umberto I, University La Sapienza, Roma, Italy. Tafaro L L Cicconetti P P Martella S S Tedeschi G G Zannino G G Troisi G G Pastena I I Fioravanti M M Marigliano V V eng Journal Article

Ireland Arch Gerontol Geriatr Suppl 8911786 0924-7947 15110832 2004 04 27 2004 12 10 2006 11 15

0968-0896 12 10 2004 May 15 Bioorg. Med. Chem. Aminyl and iminyl radicals from arylhydrazones in the photo-induced DNA cleavage. 2509-15 Photolytic cleavage of the nitrogen-nitrogen single bond in benzaldehyde phenylhydrazones produced aminyl (R2N*) and iminyl (R2C=N*) radicals. This photochemical property was utilized in the development of hydrazones as photo-induced DNA-cleaving agents. Irradiation with 350 nm UV light of arylhydrazones bearing substituents of various types in a phosphate buffer solution containing the supercoiled circular phiX174 RFI DNA at pH 6.0 resulted in single-strand cleavage of DNA. Attachment of the electron-donating OMe group to arylhydrazones increased their DNA-cleaving activity. Results from systematic studies indicate that both the aminyl and the iminyl radicals possessed DNA-cleaving ability. Institute of Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan, ROC. jrhwu@mx.nthu.edu.tw Hwu Jih Ru JR Lin Chun Chieh CC Chuang Shih Hsien SH King Ke Yung KY Su Tzu-Rong TR Tsay Shwu-Chen SC eng Journal Article Research Support, Non-U.S. Gov't

England Bioorg Med Chem 9413298 0968-0896 0 Hydrazones IM DNA Damage Hydrazones chemical synthesis chemistry Molecular Structure Photolysis 15117668 2004 04 30 2004 05 10

0022-2895 22 3 1990 Sep J Mot Behav The First Conference on Motor Control in Down Syndrome. 444-6 Latash M L ML eng Journal Article

United States J Mot Behav 0236512 0022-2895 15206831 2004 06 21 2004 07 29 2007 11 14

0896-4289 29 3 2003 Fall Behav Med Warm partner contact is related to lower cardiovascular reactivity. 123-30 The authors investigated the relationship between brief warm social and physical contact among cohabitating couples and blood pressure (BP) reactivity to stress in a sample of healthy adults (66 African American, 117 Caucasian; 74 women, 109 men). Prior to stress, the warm contact group underwent a 10-minute period of handholding while viewing a romantic video. Followed by a 20-second hug with their partner, while the no contact group rested quietly for 10 minutes and 20 seconds. In response to a public speaking task, individuals receiving prestress partner contact demonstrated lower systolic BP diastolic BP, and heart rate increases compared with the no contact group. The effects of warm contact were comparable for men and women and were greater for African Americans compared with Caucasians. These findings suggest that affectionate relationships with a supportive partner may contribute to lower reactivity to stressful life events and may partially mediate the benefit of marital support on better cardiovascular health. Department of Psychiatry, University of North Carolina at Chapel Hill, 27599-7175, USA. karen_grewen@med.unc.edu Grewen Karen M KM Anderson Bobbi J BJ Girdler Susan S SS Light Kathleen C KC eng HL64927 HL NHLBI NIH HHS United States RR00046 RR NCRR NIH HHS United States Journal Article Research Support, U.S. Gov't, P.H.S.

United States Behav Med 8804264 0896-4289 IM Adult Affect Blood Pressure physiology Body Temperature Female Heart Rate physiology Humans Life Change Events Male Marriage psychology Middle Aged Speech Spouses Touch 15228064 2004 07 01 2004 08 06 2005 11 16

1080-6032 15 2 2004 Summer Wilderness Environ Med Acute coronary ischemia following centipede envenomation: case report and review of the literature. 109-12 This is the first known case report of electrocardiographic (ECG) changes suggestive of coronary vasospasm following a centipede envenomation. A 60-year-old man presented to the emergency department (ED) 1 hour after being stung by a 12-cm centipede. He complained of right great toe pain that did not radiate to his leg. The patient had no known ischemic heart disease. He did not describe any exertional symptoms but admitted experiencing weakness. During the ED course, concurrent with obtaining peripheral intravenous access, the patient experienced diaphoresis, dizziness, hypotension, and bradycardia. His ECG showed new ST-T wave changes, which suggested an acute ischemic process. The patient's blood pressure was 89/60 mm Hg, his pulse rate was 47 beats/min, and his respiration rate was 28 breaths/min. In the following hours, ECG findings returned to baseline. His blood pressure improved gradually with fluid resuscitation after approximately 5 hours. Cardiac markers returned to normal in the 13th hour after the event, and the patient underwent exercise stress testing, which was negative. The patient was discharged with cardiology follow-up. Adult patients with centipede envenomation should be closely monitored in anticipation of possible myocardial ischemia due to vasospasm, hypotension, and myocardial toxic effects of the venom. A child receiving the same amount of venom would be potentially at greater risk. Dokuz Eylul University School of Medicine, Department of Emergency Medicine, Inciralti, Izmir, Turkey. mozsarac@hotmail.com Ozsarac Murat M Karcioglu Ozgur O Ayrik Cuneyt C Somuncu Fatih F Gumrukcu Serhat S eng Case Reports Journal Article Review

United States Wilderness Environ Med 9505185 1080-6032 IM Animals Arachnidism complications diagnosis therapy Arthropods Diagnosis, Differential Electrocardiography Emergency Treatment Humans Male Middle Aged Myocardial Ischemia complications diagnosis therapy 18 15278624 2004 07 27 2005 02 07 2009 11 03

0913-8668 5 3 1991 Jul J Anesth Hypoxic ventilatory response in cats lightly anesthetized with ketamine: effects of halothane and sevoflurane in low concentrations. 233-8 The effect of low concentration sevoflurane and halothane on the ventilatory response to isocapnic hypoxia was studied in sixteen cats. The cats were divided into two groups, sevoflurane group and halothane group, of eight subjects each. As parameters of the hypoxic ventilatory response, A value [the slope of the hyperbolic curve, V(E) = V(0) + A/(Pa(O)(2)-32)] and ratio of V(50) (the minute volume obtained from the hyperbolic equation when Pa(O)(2) = 50 mmHg) to V(0) were studied. These two parameters were examined at three states, sedative state with ketamine as the control, ketamine plus 0.1 MAC inhalation anesthetic, and ketamine plus 0.5 MAC inhalation anesthetic. In the sevoflurane group, the A values were 4789 +/- 1518, 2187 +/- 1214, 1730 +/- 880 (mean +/- SE. ml.min(-1).mmHg) at the control state, 0.1 MAC and 0.5 MAC, respectively. In the halothane group, the A values were 6411 +/- 2368, 2529 +/- 842 and 2372 +/- 545, respectively. The ratios of V(50) to V(0) were 1.32 +/- 0.09, 1.22 +/- 0.09, 1.25 +/- 0.08 in the sevoflurane group, 1.47 +/- 0.18, 1.32 +/- 0.11, 1.54 +/- 0.18 in the halothane group, respectively. The A value at 0.1 MAC of the halothane group was less than the control value significantly. This proved that even low concentration halothane depressed the hypoxic ventilatory responses. The depression of hypoxic ventilatory response could cause postanesthetic hypoventilation. On the other hand, we could not find significant depression on the hypoxic ventilatory response in the sevoflurane group, but we should notice that variances of the hypoxic ventilatory response were large. Department of Anesthesiology and Critical Care Medicine, Hamamatsu University School of Medicine, Japan. Tamura C C Doi M M Ikeda K K eng Journal Article

Japan J Anesth 8905667 0913-8668 15284444 2004 08 12 2004 09 29 2010 09 21

0027-8424 101 32 2004 Aug 10 Proc. Natl. Acad. Sci. U.S.A. Tubular precipitation and redox gradients on a bubbling template. 11537-41 Tubular structures created by precipitation abound in nature, from chimneys at hydrothermal vents to soda straws in caves. Their formation is controlled by chemical gradients within which precipitation occurs, defining a surface that templates the growing structure. We report a self-organized periodic templating mechanism producing tubular structures electrochemically in iron-ammonium-sulfate solutions; iron oxides precipitate on the surface of bubbles that linger at the tube rim and then detach, leaving behind a ring of material. The acid-base and redox gradients spontaneously generated by diffusion of ammonia from the bubble into solution organize radial compositional layering within the tube wall, a mechanism studied on a larger scale by complex Liesegang patterns of iron oxides formed as ammonia diffuses through a gel containing FeSO(4). When magnetite forms within the wall, a tube may grow curved in an external magnetic field. Connections with free-boundary problems in speleothem formation are emphasized. Department of Soil, Water, and Environmental Science, Program in Applied Mathematics, University of Arizona, Tucson, AZ 85721, USA. Stone David A DA Goldstein Raymond E RE eng Journal Article 2004 07 29

United States Proc Natl Acad Sci U S A 7505876 0027-8424 J Geol Soc London. 1997 May;154(3):377-402 11541234 Nature. 2002 May 9;417(6885):139 12000951 Philos Trans R Soc Lond B Biol Sci. 2003 Jan 29;358(1429):59-83; discussion 83-5 12594918 J Am Chem Soc. 2003 Apr 9;125(14):4338-41 12670257 Science. 2003 Oct 24;302(5645):580-1 14576411 Science. 2004 Mar 12;303(5664):1656-8 15016997 PMC511016 5757641 1970 03 22 1970 03 22 2003 11 14

15 1968 Tr Inst Fiz Akad Nauk Gruz Ssr [The effect of immediate stimulation of the hippocampus on reflex reactions in animals]. 86-96 Tevzadze V G VG geo Journal Article O vliianii neposredstvennogo razdrazheniia gippokampa na reflektornye reaktsii zhivotnykh.

USSR Tr Inst Fiz Akad Nauk Gruz Ssr 7507618 IM Animals Dogs Electric Stimulation Hippocampus physiology Reflex 973217 1976 12 03 1976 12 03 2002 11 13

0095-3814 3 1 1976 Fall Top Health Care Financ Hospital debt management and cost reimbursement. 69-81 Blume F R FR eng Journal Article

UNITED STATES Top Health Care Financ 7509107 0095-3814 IM Accounting Economics, Hospital Hospital Administration United States 3549656 1987 05 15 1987 05 15 2006 11 15

0021-8820 40 1 1987 Jan J. Antibiot. Semisynthetic beta-lactam antibiotics. III. Effect on antibacterial activity and comt-susceptibility of chlorine-introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid. 22-8 The resistance of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2- phenylacetamido]penicillanic acid (1a) to metabolism by catechol-O-methyl-transferase (COMT) was increased by introduction of the chlorine atom into the catechol moiety. Penicillins (1b-1d) having one or two chlorine atoms at the positions adjacent to the hydroxyl group were found to have greater stability to COMT. This resulted in greater efficiency in vivo in experimental Pseudomonas aeruginosa and Escherichia coli infections. In vitro activities were essentially unchanged. Ohi N N Aoki B B Kuroki T T Matsumoto M M Kojima K K Nehashi T T eng Comparative Study Journal Article

JAPAN J Antibiot (Tokyo) 0151115 0021-8820 0 Anti-Bacterial Agents 0 Indicators and Reagents 0 Penicillins 0 beta-Lactams 88852-54-4 6-(2-(3-(5-chloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid 92773-65-4 6-(2-(3-(2-chloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid 92773-66-5 6-(2-(3-(2,5-dichloro-3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido)-2-phenylacetamido)penicillanic acid EC 2.1.1.6 Catechol O-Methyltransferase IM Animals Anti-Bacterial Agents chemical synthesis pharmacology Bacteria drug effects Catechol O-Methyltransferase antagonists & inhibitors Escherichia coli Infections drug therapy Indicators and Reagents Male Mice Mice, Inbred Strains Microbial Sensitivity Tests Penicillins chemical synthesis pharmacology therapeutic use Pseudomonas Infections drug therapy Structure-Activity Relationship beta-Lactams 1875346 1991 09 25 1991 09 25 2008 11 21

0022-2623 34 8 1991 Aug J. Med. Chem. 3-Hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors. 7. Modification of the hexahydronaphthalene moiety of simvastatin: 5-oxygenated and 5-oxa derivatives. 2489-95 Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and acutely in vivo for oral effectiveness as inhibitors of cholesterogenesis in the rat. Of the compounds selected for further biological evaluation, the 6 beta-methyl-5-oxa 10 and 5 alpha-hydroxy 16 derivatives of 3,4,4a,5-tetrahydro 2a, as well as, the 6 beta-epimer 14 of 16 proved orally active as hypocholesterolemic agents in cholestyramine-primed dogs. Subsequent acute oral metabolism studies in dogs demonstrated that compounds 14 and 16 evoke lower peak plasma drug activity and area-under-the-curve values than does compound 10 and led to the selection of 14 and 16 for toxicological evaluation. Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486. Duggan M E ME Alberts A W AW Bostedor R R Chao Y S YS Germershausen J I JI Gilfillan J L JL Halczenko W W Hartman G D GD Hunt V V Imagire J S JS eng Journal Article

UNITED STATES J Med Chem 9716531 0022-2623 0 6-(2-(8-(2,2-dimethylbutyryl)oxy)-2,6-dimethyl-5-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 0 Acetates 0 Anticholesteremic Agents 0 Hydroxymethylglutaryl-CoA Reductase Inhibitors 57-88-5 Cholesterol 75330-75-5 Lovastatin 7782-44-7 Oxygen 79902-63-9 Simvastatin IM Acetates metabolism Animals Anticholesteremic Agents chemical synthesis pharmacokinetics pharmacology Chemical Phenomena Chemistry Cholesterol biosynthesis Dogs Hydroxymethylglutaryl-CoA Reductase Inhibitors Kinetics Lovastatin analogs & derivatives chemical synthesis chemistry pharmacokinetics pharmacology Male Molecular Conformation Molecular Structure Oxygen Rats Simvastatin Structure-Activity Relationship 1669026 1993 11 15 1993 11 15 2008 11 21

0377-8231 Anniv No Pt 1 1991 Bull. Mem. Acad. R. Med. Belg. [150th Anniversary Celebration of the Royal Academy of Medicine of Belgium. Part 1. Bruxelles, 26-28 September 1991]. 1-191 fre Congresses Overall Portraits Célébration du CL Anniversaire de l'Académie Royal de Médecine de Belgique. Première partie. Bruxelles, 26-28 septembre 1991.

BELGIUM Bull Mem Acad R Med Belg 7608462 0377-8231 IM Academies and Institutes Belgium 8219565 1993 12 08 1993 12 08 2004 11 17

1051-0443 4 5 1993 Sep-Oct J Vasc Interv Radiol Transcatheter manipulation of asymmetrically opened titanium Greenfield filters. 687-90 The problem of asymmetric opening of the modified hook titanium Greenfield inferior vena cava filter necessitating transcatheter manipulation was evaluated in a retrospective study. Titanium Greenfield filters were placed in 166 patients over a 36-month period. The radiographic reports of all patients were reviewed to identify cases in which the filter failed to open symmetrically after deployment and catheter or wire manipulation of the filter was performed. The reports and angiograms from these patients were reviewed with respect to the circumstances surrounding filter placement and methods to achieve more symmetric opening. Transcatheter manipulation of asymmetrically opened filters was performed in 15 of 166 cases (9%). In 12 of these patients, acceptable and uneventful opening of the filter was achieved with a guide wire, pigtail catheter, or occlusion balloon catheter. In one case manipulation only partly improved orientation of the limbs, while in another case successful manipulation was complicated by distal migration. In the final case, the asymmetric filter covered only part of the lumen of the vena cava despite manipulations and a second filter was placed for optimal caval interruption. No specific cause for incomplete expansion was identified in any case. Marked asymmetry in opening of the modified hook titanium Greenfield filter that warrants manipulation occurs infrequently, but recognition and proper management may be important to ensure optimal caval interruption. Department of Radiology, University of California at San Diego 92103. Moore B S BS Valji K K Roberts A C AC Bookstein J J JJ eng Journal Article

UNITED STATES J Vasc Interv Radiol 9203369 1051-0443 7440-32-6 Titanium IM J Vasc Interv Radiol. 1993 Sep-Oct;4(5):617-20 8219555 J Vasc Interv Radiol. 1994 May-Jun;5(3):526-7 8054760 J Vasc Interv Radiol. 1994 May-Jun;5(3):528-32 8054761 Catheterization, Central Venous Humans Titanium Vena Cava Filters Vena Cava, Inferior radiography 8119288 1994 04 01 1994 04 01 2007 07 23

0014-2956 220 1 1994 Feb 15 Eur. J. Biochem. Purification and characterisation of a water-soluble ferrochelatase from Bacillus subtilis. 201-8 Bacillus subtilis ferrochelatase is encoded by the hemH gene of the hemEHY gene cluster and catalyses the incorporation of Fe2+ into protoporphyrin IX. B. subtilis ferrochelatase produced in Escherichia coli was purified. It was found to be a monomeric, water-soluble enzyme of molecular mass 35 kDa which in addition to Fe2+ can incorporate Zn2+ and Cu2+ into protoporphyrin IX. Chemical modification experiments indicated that the single cysteine residue in the ferrochelatase is required for enzyme activity although it is not a conserved residue compared to other ferrochelatases. In growing B. subtilis, the ferrochelatase constitutes approximately 0.05% (by mass) of the total cell protein, which corresponds to some 600 ferrochelatase molecules/cell. The turnover number of isolated ferrochelatase, 18-29 min-1, was found to be consistent with the rate of haem synthesis in exponentially growing cells (0.2 mol haem formed/min/mol enzyme). It is concluded that the B. subtilis ferrochelatase has enzymic properties which are similar to those of other characterised ferrochelatases of known primary structure, i.e. ferrochelatases of the mitochondrial inner membrane of yeast and mammalian cells. However, in contrast to these enzymes the B. subtilis enzyme is a water-soluble protein and should be more amenable to structural analysis. Department of Microbiology, Lund University, Sweden. Hansson M M Hederstedt L L eng Journal Article Research Support, Non-U.S. Gov't

GERMANY Eur J Biochem 0107600 0014-2956 7732-18-5 Water EC 4.99.1.1 Ferrochelatase IM hemE hemH hemY Amino Acid Sequence Bacillus subtilis enzymology genetics Catalysis Cloning, Molecular Escherichia coli enzymology genetics Ferrochelatase genetics isolation & purification metabolism Gene Deletion Genes, Bacterial Kinetics Molecular Sequence Data Molecular Weight Solubility Water 11537092 1995 06 16 1995 06 16 2008 11 21

0033-183X 163 1991 Protoplasma Cytoplasmic calcium levels in protoplasts from the cap and elongation zone of maize roots. 181-8 Calcium has been implicated as a key component in the signal transduction process of root gravitropism. We measured cytoplasmic free calcium in protoplasts isolated from the elongation zone and cap of primary roots of light-grown, vertically oriented seedlings of Zea mays L. Protoplasts were loaded with the penta-potassium salts of fura-2 and indo-1 by incubation in acidic solutions of these calcium indicators. Loading increased with decreasing pH but the pH dependence was stronger for indo-1 than for fura-2. In the case of fura-2, loading was enhanced only at the lowest pH (4.5) tested. Dyes loaded in this manner were distributed predominantly in the cytoplasm as indicated by fluorescence patterns. As an alternative method of loading, protoplasts were incubated with the acetoxymethylesters of fura-2 and indo-1. Protoplasts loaded by this method exhibited fluorescence both in the cytoplasm and in association with various organelles. Cytoplasmic calcium levels measured using spectrofluorometry, were found to be 160 +/- 40 nM and 257 +/- 27 nM, respectively, in populations of protoplasts from the root cap and elongation zone. Cytoplasmic free calcium did not increase upon addition of calcium to the incubation medium, indicating that the passive permeability to calcium was low. Department of Plant Biology, Ohio State University, Columbus. Kiss H G HG Evans M L ML Johnson J D JD eng DMB 8608673 MB BHP HRSA HHS United States Journal Article Research Support, U.S. Gov't, Non-P.H.S.

AUSTRIA Protoplasma 9806853 0033-183X 0 Fluorescent Dyes 0 Indoles 7440-70-2 Calcium 96314-96-4 indo-1 96314-98-6 Fura-2 S Calcium analysis physiology Cytoplasm chemistry Fluorescent Dyes Fura-2 Gravitropism physiology Gravity Sensing physiology Indoles Plant Root Cap cytology growth & development physiology Plant Roots cytology growth & development physiology Protoplasts chemistry physiology Signal Transduction Zea mays cytology growth & development physiology 00015446 NASA Discipline Number 40-50 NASA Discipline Plant Biology NASA Program Space Biology Non-NASA Center Evans M L ML Ohio St U, Columbus, Dept Physiological Chemistry Grant numbers: NAGW 297 11540070 1995 12 11 1995 12 11 2011 11 17

0735-2689 6 1 1987 CRC Crit Rev Plant Sci Calcium messenger system in plants. 47-103 Department of Horticulture, Washington State University, Pullman, USA. Poovaiah B W BW Reddy A S AS eng DCB-8502215 DC NIDCD NIH HHS United States Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

UNITED STATES CRC Crit Rev Plant Sci 9889759 0735-2689 0 Calcium-Binding Proteins 0 Calmodulin 0 Plant Growth Regulators 7440-70-2 Calcium EC 2.7.11.17 Calcium-Calmodulin-Dependent Protein Kinases S Amino Acid Sequence Calcium physiology Calcium-Binding Proteins physiology Calcium-Calmodulin-Dependent Protein Kinases metabolism Calmodulin metabolism Gene Expression Regulation, Plant Gravitropism physiology Molecular Sequence Data Plant Cells Plant Growth Regulators metabolism Plant Physiological Phenomena Plants genetics Second Messenger Systems Signal Transduction physiology 363 00012050 The purpose of this review is to delineate the ubiquitous and pivotal role of Ca2+ in diverse physiological processes. Emphasis will be given to the role of Ca2+ in stimulus-response coupling. In addition to reviewing the present status of research, our intention is to critically evaluate the existing data and describe the newly developing areas of Ca2+ research in plants. NASA Edited NASA Discipline Number 40-30 NASA Discipline Plant Biology NASA Program Space Biology Non-NASA Center Poovaiah B W BW WA St U, Pullman, Dept Horticulture Grant numbers: NAG-10-0032 8655018 1996 07 30 1996 07 30 2008 11 21

0017-0011 67 1 1996 Jan Ginekol. Pol. [Effect of fetal and neonatal growth on the occurrence of some diseases in adults]. 34-6 The findings of many authors show that reduced fetal growth is followed by increased mortality from cardiovascular disease in adult life. They are further evidence that cardiovascular disease originates, among other risk factors, through programming of the bodies structure and metabolism during fetal and early post-natal life. Wrong maternal nutrition may have an important influence on programming. Katedry i Zakładu Chemii i Analizy Leków, AM w Katowicach. Jendryczko A A Poreba R R pol English Abstract Journal Article Retracted Publication Review Wpływ przebiegu rozwoju płodu i noworodka na ujawnienie sie niektórych chorób okresu dorosłego.

POLAND Ginekol Pol 0374641 0017-0011 IM Ginekol Pol. 1998 Jul;69(7):561 9867475 Ginekol Pol. 1998 Jul;69(7):559-60 9867474 Adult Cardiovascular Diseases etiology mortality Child Development physiology Embryonic and Fetal Development physiology Fetal Growth Retardation complications physiopathology Humans Infant, Newborn Nutritional Physiological Phenomena Risk Factors Survival Rate 11 9110943 1996 10 23 1996 10 23 2011 11 17

1059-2725 Doc No 200-201 1996 Jul 30 Online J Curr Clin Trials Conservative management of mechanical neck disorders. A systematic overview and meta-analysis. [34457 words; 185 paragraphs] This overview reports the efficacy of conservative treatments (drug therapy, manual therapy, patient education, physical medicine modalities) in reducing pain in adults with mechanical neck disorders. Computerized bibliographic database searches from 1985 to December 1993, information requests from authors, and bibliography screenings were used to identify published and unpublished research. Applying strict criteria, two investigators independently reviewed the blinded articles. Each selected trial was evaluated independently for methodologic quality. Twenty-four randomized controlled trials (RCTs) and eight before-after studies met our selection criteria. Twenty RCTs rated moderately strong or better in terms of methodologic quality. Five trials using manual therapy in combination with other treatments were clinically similar, were statistically not heterogeneous (p = 0.98), and were combined to yield an effect size of -0.6 (95% CI: -0.9, -0.4), equivalent to a 16 point improvement on a 100 point pain scale. Four RCTs using physical medicine modalities were combined using the inverse chi-square method: two using electromagnetic therapy produced a significant reduction in pain (p < 0.01); and two using laser therapy did not differ significantly from a placebo (p = 0.63). Little or no scientific evidence exists for other therapies, including such commonly used treatments as medication, rest and exercise. Within the limits of methodologic quality, the best available evidence supports the use of manual therapies in combination with other treatments for short-term relief of neck pain. There is some support for the use of electromagnetic therapy and against the use of laser therapy. In general, other interventions have not been studied in enough detail adequately to assess efficacy or effectiveness. This overview provides the foundation for an evidence-based approach to practice. More robust design and methodology should be used in future research, in particular, the use of valid and reliable outcomes measures. Chedoke-McMaster Hospitals & Schools of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada. Gross A R AR Aker P D PD Goldsmith C H CH Peloso P P eng Journal Article Meta-Analysis Research Support, Non-U.S. Gov't

UNITED STATES Online J Curr Clin Trials 9300367A 1059-2725 IM Acupuncture Therapy Adult Chiropractic Databases, Bibliographic Humans Manipulation, Orthopedic Neck Injuries Pain drug therapy rehabilitation Pain Management Patient Education as Topic Physical Therapy Modalities Randomized Controlled Trials as Topic Reproducibility of Results Wounds and Injuries drug therapy rehabilitation therapy 11612527 1991 03 18 1991 03 18 2007 11 15

0032-4728 44 3 1990 Nov Popul Stud (Camb) On the origins of the United States Government's international population policy. 385-99 Donaldson P J PJ eng Historical Article Journal Article

ENGLAND Popul Stud (Camb) 0376427 0032-4728 E Q QO Demography History, Modern 1601- Politics Statistics as Topic history United States World Health 36117 Agency for International Development Genetics and Reproduction 50 fn. KIE Bib: population control 11620107 1988 11 16 1988 11 16 2007 11 15

0511-0726 24 1984 A A G Bijdr Demographic transition in the Netherlands: a statisticsl analysis of regional differences in the level and development of the birth rate and of fertility, 1850-1890. 1-57 Boonstra O W OW van der Woude A M AM eng Historical Article Journal Article

NETHERLANDS A A G Bijdr 100966038 0511-0726 Q QO Demography History, Modern 1601- Netherlands Statistics as Topic history 11675721 1976 07 01 1976 07 01 2007 11 15

0024-2160 2 2 1974 Jun Library (Lond) Thomas Dover's "Ancient physician's legacy". 228 Payne L M LM eng Biography Historical Article Journal Article

ENGLAND Library (Lond) 100969413 0024-2160 Q QO Bibliography as Topic Great Britain History, Modern 1601- Printing history Dover T T 8863847 1996 11 25 1996 11 25 2009 11 19

0026-895X 50 4 1996 Oct Mol. Pharmacol. Mechanism of extracellular ATP-induced proliferation of vascular smooth muscle cells. 1000-9 The mitogenic effect of extracellular ATP was examined in cultured rat aortic smooth muscle cells (VSMCs). ATP, 2-methylthio-ATP, and ADP stimulated [3H]thymidine and [3H]leucine incorporation and cell growth. AMP, adenosine, UTP, and P2x agonists showed little of these effects. Reactive blue 2, a P2Y purinoceptor antagonist, was effective in suppressing the mitogenic effect of ATP and 2-methylthio-ATP, indicating that extracellular ATP-induced VSMC proliferation is mediated by P2Y purinoceptors. The P2Y purinoceptor activation was coupled to a pertussis toxin (PTX)-insensitive G protein (Gq) and triggered phosphoinositide hydrolysis with subsequent activation of protein kinase C (PKC), Raf-1, and mitogen-activated protein kinase (MAPK) in VSMCs. In response to ATP, both 42-and 44-kDa MAPKs were activated, and tyrosine was phosphorylated. Western blot analysis using PKC isozyme-specific antibodies indicated that VSMCs express PKC-alpha, PKC-delta, and PKC-zeta. A complete down-regulation of PKC-alpha and PKC-delta was seen after 24-hr treatment with 12-O-tetradecanoylphorbol-13-acetate. When cells were pretreated with 12-O-tetradecanoyl-phorbol-13-acetate for 24 hr and subsequently challenged with ATP, Raf-1 activation and 42-kDa as well as 44-kDa MAPK tyrosine phosphorylation failed to be induced. These results demonstrate that ATP-induced Raf-1 and MAPK activations involve the activation of PKC-alpha and PKC-delta. P2Y purinoceptor stimulation with ATP also caused accumulation of c-fos and c-myc mRNAs. Both Reactive blue 2 and staurosporine significantly blocked this increase by ATP. In conclusion, the mitogenic effect of ATP seemed to be triggered by activation of the Gq protein-coupled P2Y purinoceptor that led to the formation of inositol trisphosphate and activation of PKC. PKC and, in turn, Raf-1 and MAPK were then activated, leading eventually to DNA synthesis and cell proliferation. Department of Pharmacology, Chang Gung College of Medicine and Technology, Kwei-San, Tao-Yuan, Taiwan. smyu@cguaplo.cgu.edu Yu S M SM Chen S F SF Lau Y T YT Yang C M CM Chen J C JC eng In Vitro Journal Article Research Support, Non-U.S. Gov't Retracted Publication

UNITED STATES Mol Pharmacol 0035623 0026-895X 0 Proto-Oncogene Proteins 0 RNA, Messenger 0 Receptors, Purinergic P2 0 Transcription Factors 10028-17-8 Tritium 50-89-5 Thymidine 56-65-5 Adenosine Triphosphate 61-90-5 Leucine 9007-49-2 DNA EC 2.7.11.1 Protein-Serine-Threonine Kinases EC 2.7.11.1 Proto-Oncogene Proteins c-raf EC 2.7.11.13 Protein Kinase C EC 2.7.11.17 Calcium-Calmodulin-Dependent Protein Kinases EC 3.6.1.- GTP-Binding Proteins IM Mol Pharmacol 1997 Mar;51(3):533 Wu D, Yang CM, Lau YT, Chen JC. Mol Pharmacol. 1998 Feb;53(2):346 9499167 Adenosine Triphosphate pharmacology Animals Aorta cytology drug effects metabolism Calcium-Calmodulin-Dependent Protein Kinases metabolism Cell Count Cell Division drug effects Cells, Cultured DNA biosynthesis Enzyme Activation Extracellular Space metabolism GTP-Binding Proteins metabolism physiology Leucine metabolism Muscle, Smooth, Vascular cytology drug effects metabolism Protein Kinase C metabolism Protein-Serine-Threonine Kinases metabolism Proto-Oncogene Proteins metabolism Proto-Oncogene Proteins c-raf RNA, Messenger metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P2 physiology Signal Transduction physiology Stimulation, Chemical Thymidine metabolism Transcription Factors biosynthesis Tritium 8941094 1997 01 02 1997 01 02 2004 11 17

0009-7322 94 11 1996 Dec 1 Circulation Assessment of myocardial viability in patients with chronic coronary artery disease. Rest-4-hour-24-hour 201Tl tomography versus dobutamine echocardiography. 2712-9 To date, late redistribution after resting 201Tl injection has not been evaluated. In addition, the concordance between resting 201Tl imaging and dobutamine echocardiography in identifying viable myocardium has not been assessed. Forty patients with coronary artery disease underwent rest-4-hour-24-hour 201Tl tomography and dobutamine echocardiography (5 to 10 micrograms.kg-1.min-1). Late redistribution occurred in 46 (21%) of 219 persistent defects at 4 hours. Systolic function and contractile reserve were similar among persistent defects at 4 hours with and without late redistribution. Contractile reserve was more frequent in segments with normal 201Tl uptake (59%), completely reversible defects (53%), or mild to moderate defects at 4 hours (56%) compared with severe defects (14%; P < .02 versus all). Of 105 hypokinetic segments, 99 (94%) were viable by 201Tl, and 88 (84%) showed contractile reserve. In contrast, of 155 akinetic segments, 119 (77%) were viable by 201Tl, but only 34 (22%) had contractile reserve. Concordance between 201Tl and dobutamine was 82% in hypokinetic segments but 43% in akinetic segments. In 109 revascularized segments, positive accuracy for functional recovery was 72% for 201Tl and 92% for dobutamine, whereas negative accuracy was 100% and 65%, respectively. Sensitivity was 100% for 201Tl and 79% for dobutamine. Late redistribution occurs in one fifth of persistent defects at 4 hours, and it does not correlate to systolic function or contractile reserve. Dobutamine and 201Tl yield concordant information in the majority of hypokinetic segments, whereas concordance is low in akinetic segments. Dobutamine demonstrates higher positive accuracy and sensitivity in predicting recovery of dysfunctional myocardium, whereas 201Tl shows higher negative predictive accuracy but reduced positive accuracy. Division of Cardiology, Federico II University Medical School, Naples, Italy. Perrone-Filardi P P Pace L L Prastaro M M Squame F F Betocchi S S Soricelli A A Piscione F F Indolfi C C Crisci T T Salvatore M M Chiariello M M eng Journal Article

UNITED STATES Circulation 0147763 0009-7322 0 Thallium Radioisotopes 34368-04-2 Dobutamine AIM IM Circulation. 1997 Oct 21;96(8):2740-2 9355926 Circulation. 1996 Dec 1;94(11):2681-4 8941086 Circulation. 1996 Dec 1;94(11):2674-80 8941085 Circulation. 1996 Dec 1;94(11):2685-8 8941087 Aged Cell Survival Chronic Disease Circadian Rhythm Coronary Disease physiopathology radionuclide imaging ultrasonography Dobutamine diagnostic use Echocardiography Follow-Up Studies Heart radionuclide imaging Humans Male Middle Aged Myocardial Contraction Myocardial Revascularization Rest Systole Thallium Radioisotopes diagnostic use pharmacokinetics Time Factors Ventricular Dysfunction, Left radionuclide imaging therapy ultrasonography 10168751 1997 08 28 1997 08 28 2006 11 15

0168-8510 40 3 1997 Jun Health Policy Health technology assessment: decentralized and fragmented in the US compared to other countries. 177-98 This paper presents the results of the first comprehensive international survey to catalogue health technology assessment (HTA) activities. By 1995, there were formal HTA programs in 24 countries established mostly in the late 1980s and early 1990s. European countries generally have one or two federal or provincial HTA programs each, Canada has an extensive network of federal and regional organizations coordinated by a central body and the US has 53 HTA organizations, the vast majority of which are in the private sector. While the commitment of the US government to HTA has been erratic, the private sector has been witness to an expansion of HTA activities by insurance companies, hospitals, medical/device manufacturers, consulting firms and health professional societies. In contrast to other developed countries, the current state of technology assessment in the US is decentralized, fragmented and duplicative. We conclude by discussing the importance of a US HTA agency at the national level. Medical Technology and Practice Patterns Institute, WHO Collaborating Center on Health Technology Assessment, Washington, DC 20007, USA. Perry S S Thamer M M eng Comparative Study Journal Article Research Support, Non-U.S. Gov't

IRELAND Health Policy 8409431 0168-8510 H Health Policy 1997 Dec;42(3):269-90 Canada Diffusion of Innovation Europe Health Care Surveys Health Policy Information Services Private Sector Technology Assessment, Biomedical legislation & jurisprudence methods organization & administration statistics & numerical data United States United States Office of Technology Assessment 9394824 1998 01 02 1998 01 02 2006 11 15

0014-2980 27 11 1997 Nov Eur. J. Immunol. Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells. 2959-64 In this work we have microdissected lamina propria plasma cells and used polymerase chain reaction and sequencing to investigate immunoglobulin (Ig) gene rearrangements and mutations in human intestine. In addition, specific primers were designed for individual Ig gene rearrangements to analyze the distribution of related B cell and plasma cell clones at different sites along the bowel. Confirming our earlier work, intestinal IgVH genes were highly mutated in plasma cells from older individuals (> 30 years). IgVH genes were significantly less mutated in samples taken from patients aged 11-30 years, and there were fewer mutations again in samples from young children (< 11 years). In age-matched specimens the number of mutations was equivalent in the duodenum and colon. Using complementarity-determining region 3 primers to amplify specific Ig gene rearrangements, evidence was also found for the existence of related lamina propria plasma cells along the small bowel and colon, although these were quite scarce. In addition, analysis of the numbers of related clones in a random sampling from discrete areas of lamina propria indicates that the local population is diverse. These results suggest that the highly mutated IgVH genes in adult intestinal plasma cells are a consequence of chronic antigen exposure with age. Duodenal plasma cells are as highly mutated as colonic plasma cells, despite the fact that the upper bowel has no indigenous microbial flora (the stimulus for intestinal plasma cells). They also show that the plasma cell population is diverse and can be widely disseminated along the bowel. Department of Histopathology, UMDS, London, Great Britain. Dunn-Walters D K DK Boursier L L Spencer J J eng GENBANK Z93128 Z93129 Z93130 Z93131 Z93132 Z93133 Z93134 Z93135 Z93136 Z93137 Z93138 Z93139 Z93140 Z93141 Z93142 Z93143 Z93144 Z93145 Z93146 Z93147 Z93148 Z93149 Z93150 Z93151 Z93152 Z93153 Z93154 Z93155 Z93156 Z93157 Journal Article Research Support, Non-U.S. Gov't

GERMANY Eur J Immunol 1273201 0014-2980 0 Immunoglobulin Heavy Chains 0 Immunoglobulin Variable Region IM Adolescent Adult Aged Aged, 80 and over Aging genetics immunology Base Sequence Child Colon immunology metabolism Duodenum immunology metabolism Gene Rearrangement immunology Genes, Immunoglobulin Humans Immunoglobulin Heavy Chains genetics Immunoglobulin Variable Region genetics Infant Intestinal Mucosa cytology immunology Middle Aged Molecular Sequence Data Mutation Organ Specificity genetics immunology Plasma Cells immunology metabolism 9482442 1998 03 18 1998 03 18 2004 11 17

0140-6736 351 9101 1998 Feb 14 Lancet A woman with nodules in her lungs. 494 Department of Medicine, Turku University Central Hospital, Finland. Järveläinen H H Vainionpää H H Kuopio T T Lehtonen A A eng Case Reports Journal Article

ENGLAND Lancet 2985213R 0140-6736 0 Powders 7631-86-9 Silicon Dioxide AIM IM Lancet 1998 Mar 7;351(9104):760 Lancet 1998 Jun 27;351(9120):1968 Aged Female Humans Naturopathy Powders Silicon Dioxide administration & dosage Silicosis etiology radiography 9505772 1998 03 24 1998 03 24 2004 11 17

0007-0912 80 1 1998 Jan Br J Anaesth Myocardial ischaemia after coronary artery bypass grafting: early vs late extubation. 20-5 The technique of early extubation after coronary artery bypass grafting is increasing in popularity, but its safety and effect on myocardial ischaemia remain to be established. In a randomized, prospective study, patients undergoing routine elective coronary artery bypass grafting were managed with either early or late tracheal extubation. The incidence and severity of electrocardiographic myocardial ischaemia were compared. Data were analysed from 85 patients (43 early extubation; 42 late extubation). Median time to extubation was 110 min in the early extubation patients and 757 min in the late extubation patients. After correction for randomization bias, there were no significant differences between groups in ischaemic burden, maximal ST-segment deviation, incidence of ischaemia and area under the ST deviation-time curve (integral of ST deviation and time). Similarly, there were no differences between groups in postoperative creatine kinase MB-isoenzyme concentrations and duration of stay in the ICU or hospital. Therefore, this study provides evidence for the safety of early extubation after routine coronary artery bypass grafting. Cardiothoracic Centre Liverpool-NHS Trust. Berry P D PD Thomas S D SD Mahon S P SP Jackson M M Fox M A MA Fabri B B Weir W I WI Russell G N GN eng Clinical Trial Journal Article Randomized Controlled Trial

ENGLAND Br J Anaesth 0372541 0007-0912 IM Br J Anaesth 1998 Apr;80(4):572 Br J Anaesth 1998 Jul;81(1):111 Adult Aged Coronary Artery Bypass adverse effects Electrocardiography Female Humans Intubation, Intratracheal methods Male Middle Aged Myocardial Ischemia etiology Postoperative Care methods Postoperative Period Prospective Studies Treatment Outcome 9575322 1998 05 12 1998 05 12 2007 11 15

0002-838X 57 8 1998 Apr 15 Am Fam Physician Lumbar spine stenosis: a common cause of back and leg pain. 1825-34, 1839-40 Lumbar spine stenosis most commonly affects the middle-aged and elderly population. Entrapment of the cauda equina roots by hypertrophy of the osseous and soft tissue structures surrounding the lumbar spinal canal is often associated with incapacitating pain in the back and lower extremities, difficulty ambulating, leg paresthesias and weakness and, in severe cases, bowel or bladder disturbances. The characteristic syndrome associated with lumbar stenosis is termed neurogenic intermittent claudication. This condition must be differentiated from true claudication, which is caused by atherosclerosis of the pelvofemoral vessels. Although many conditions may be associated with lumbar canal stenosis, most cases are idiopathic. Imaging of the lumbar spine performed with computed tomography or magnetic resonance imaging often demonstrates narrowing of the lumbar canal with compression of the cauda equina nerve roots by thickened posterior vertebral elements, facet joints, marginal osteophytes or soft tissue structures such as the ligamentum flavum or herniated discs. Treatment for symptomatic lumbar stenosis is usually surgical decompression. Medical treatment alternatives, such as bed rest, pain management and physical therapy, should be reserved for use in debilitated patients or patients whose surgical risk is prohibitive as a result of concomitant medical conditions. University Hospitals of Cleveland/Case Western Reserve University, Cleveland, Ohio, USA. Alvarez J A JA Hardy R H RH Jr eng Journal Article Review

UNITED STATES Am Fam Physician 1272646 0002-838X AIM IM Am Fam Physician. 1999 Jan 15;59(2):280, 283-4 9930124 Diagnosis, Differential Humans Low Back Pain etiology Lumbosacral Region Pain etiology Patient Education as Topic Spinal Stenosis complications diagnosis physiopathology therapy Teaching Materials 13 9626910 1998 08 12 1998 08 12 2006 11 15

0047-1828 62 5 1998 May Jpn. Circ. J. Hepatitis C virus infection and heart diseases: a multicenter study in Japan. 389-91 As a collaborative research project of the Committees for the Study of Idiopathic Cardiomyopathy, a questionnaire was sent out to 19 medical institutions in Japan in order to examine the possible association between hepatitis C virus (HCV) infection and cardiomyopathies. Hepatitis C virus antibody was found in 74 of 697 patients (10.6%) with hypertrophic cardiomyopathy (mean age, 57.7 years) and in 42 of 663 patients (6.3%) with dilated cardiomyopathy (mean age, 56.5 years); these prevalences were significantly higher than that found in volunteer blood donors in Japan (2.4%, 50-59 years of age, each p<0.0001). The prevalence was significantly higher in patients suffering from hypertrophic cardiomyopathy as opposed to those with dilated cardiomyopathy (p<0.01). The presence of HCV antibody was detected in 650 of 11,967 patients (5.4%) patients seeking care in 5 academic hospitals. Various cardiac abnormalities were found among these patients, arrhythmias being the most frequent. These observations suggest that HCV infection is an important cause of a variety of otherwise unexplained heart diseases. Kyoto University, Japan. Matsumori A A Ohashi N N Hasegawa K K Sasayama S S Eto T T Imaizumi T T Izumi T T Kawamura K K Kawana M M Kimura A A Kitabatake A A Matsuzaki M M Nagai R R Tanaka H H Hiroe M M Hori M M Inoko H H Seko Y Y Sekiguchi M M Shimotohno K K Sugishita Y Y Takeda N N Takihara K K Tanaka M M Yokoyama M M eng Journal Article Multicenter Study Research Support, Non-U.S. Gov't

AUSTRALIA Jpn Circ J 7806868 0047-1828 0 Hepatitis C Antibodies IM Cardiomyopathies epidemiology etiology virology Heart virology Heart Diseases epidemiology etiology virology Hepacivirus immunology Hepatitis C complications Hepatitis C Antibodies blood Humans Japan epidemiology Middle Aged Myocardium immunology pathology Prevalence Questionnaires 9627170 1998 08 25 1998 08 25 2006 11 15

1435-2443 383 1 1998 Mar Langenbecks Arch Surg Outcome of patients with sepsis and septic shock after ICU treatment. 44-8 OBJECTIVE: Today, sepsis syndrome is the leading cause of death in adult, non-coronary intensive care units (ICUs) and is of great clinical importance. The purpose of this review was to evaluate recent prospective studies concerning the short- and long-term prognosis of patients suffering from systemic inflammatory-response syndrome (SIRS), sepsis, severe sepsis and septic shock. It has been shown in multicentre prospective surveys that 1% and 0.3% of all patients admitted to hospitals suffer, respectively, from bacteraemia alone and bacteraemia with severe sepsis. This rate increases, of course, when only admissions to the ICUs are considered: the above-mentioned rates increase then by a factor of 8 and 30, respectively. Thus, approximately 10% of patients in the ICU suffer from sepsis, 6% from severe sepsis and 2-3% from septic shock. SIRS occurs more frequently and its occurrence ranges from 40% to 70% of all patients admitted to ICUs. Thereby, 40-70% suffering from SIRS progress to a more severe septic-disease state. The overall prognosis is still poor, despite the recent advances in ICU treatment. The mortality rate of SIRS ranges from 6% to 7% and in septic shock amounts to over 50%. In particular, abdominal sepsis exhibits the highest mortality rate with 72%. The long-term prognosis is equally poor; only approximately 30% survived the first year after hospital admission. CONCLUSION: The prognosis of sepsis and septic shock remains poor, despite the advances in ICU treatment. Although prognostic factors have been identified for some patients, groups have not yet been able to identify the immediate or long-term prognosis for the majority of these septic patients. Department of General Surgery, University of Ulm, Germany. Schoenberg M H MH Weiss M M Radermacher P P eng Journal Article Review

GERMANY Langenbecks Arch Surg 9808285 1435-2443 IM Adult Bacteremia mortality therapy Cause of Death Female Humans Intensive Care Male Prognosis Prospective Studies Shock, Septic mortality therapy Surgical Wound Infection mortality therapy Survival Rate Systemic Inflammatory Response Syndrome mortality therapy 21 9634358 1998 06 18 1998 06 18 2004 03 31

0022-1899 177 6 1998 Jun J. Infect. Dis. Retraction: A rabbit model for human cytomeglovirus--induced chorioretinal disease (J Infect Dis 1993;168:336-44). 1778 Dunkel E C EC Scheer D I DI Zhu Q Q Whitley R J RJ Schaffer P A PA Pavan-Langston D D Whitely R J RJ eng Retraction of Publication

UNITED STATES J Infect Dis 0413675 0022-1899 AIM IM J Infect Dis 1998 Aug;178(2):601 Whitely RJ [corrected to Whitley RJ] Dunkel EC, de Freitas D, Scheer DI, Siegel ML, Zhu Q, Whitley RJ, Schaffer PA, Pavan-Langston D. J Infect Dis. 1993 Aug;168(2):336-44 8393056 9861576 1999 03 29 1999 03 29 2010 02 25

0268-1315 13 6 1998 Nov Int Clin Psychopharmacol Cardiac side-effects of two selective serotonin reuptake inhibitors in middle-aged and elderly depressed patients. 263-7 Selective serotonin reuptake inhibitors (SSRIs) are the 'new' drugs of first choice for the treatment of depression in the older patient. Systematic studies on the effects of SSRIs on cardiac function are scarce, despite the high prevalence of cardiac disorders in the older depressed patient. This is a study which systematically assessed cardiac function by echocardiography in middle-aged and elderly depressed patients treated with SSRI. In a double-blind randomized trial, 20 patients were assigned to receive fluvoxamine 100 mg/day [DOSAGE ERROR CORRECTED] or fluoxetine 20 mg/day [DOSAGE ERROR CORRECTED] for 6 weeks. Cardiac function was assessed by left ventricle ejection fraction, aortic flow integral and early or passive/late or active mitral inflow, and electrocardiography. Neither SSRI significantly affected cardiac function. Compared with patients without a history of myocardial infarction and/or hypertension, patients with such a history showed a significant improvement in left ventricular ejection fraction. Despite our small study sample, these data indicate that both fluoxetine and fluvoxamine do not affect cardiac function adversely. Department of Psychiatry, Maastricht University Hospital, The Netherlands. Strik J J JJ Honig A A Lousberg R R Cheriex E C EC Van Praag H M HM eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

ENGLAND Int Clin Psychopharmacol 8609061 0268-1315 0 Serotonin Uptake Inhibitors 54739-18-3 Fluvoxamine 54910-89-3 Fluoxetine IM Int Clin Psychopharmacol 1999 Mar;14(2):138 Dosage error in published abstract; MEDLINE/PubMed abstract corrected Aged Aged, 80 and over Cardiovascular Diseases chemically induced physiopathology Depressive Disorder complications drug therapy Double-Blind Method Echocardiography Electrocardiography drug effects Female Fluoxetine adverse effects therapeutic use Fluvoxamine adverse effects therapeutic use Humans Male Middle Aged Serotonin Uptake Inhibitors adverse effects therapeutic use 9885794 1999 03 29 1999 03 29 2011 05 18

0893-133X 20 2 1999 Feb Neuropsychopharmacology Antipsychotic potential of CCK-based treatments: an assessment using the prepulse inhibition model of psychosis. 141-9 Systemic injections of cholecystokinin (CCK), a "gut-brain" peptide, have been shown to modulate brain dopamine function and produce neuroleptic-like effects on such dopamine-regulated behaviors as locomotor activity. However, clinical trials of CCK agonists in schizophrenia patients showed mixed results. To re-examine the antipsychotic potential of CCK-based treatments, we examined systemic injections of CCK analogs in an animal model with strong face and construct validity for sensorimotor-gating deficits seen in schizophrenia patients and with strong predictive validity for antipsychotic drug activity. Prepulse inhibition (PPI) occurs when a weak acoustic lead stimulus ("prepulse") inhibits the startle response to a sudden loud sound ("pulse"). PPI is significantly reduced in schizophrenia patients and rats treated with dopamine agonists. Antipsychotics reverse decreased PPI in rats to a degree highly correlated with their clinical efficacy. Subcutaneous (s.c.) injections of caerulein (10 micrograms/kg) a mixed CCKA/B agonist, partially reversed amphetamine-induced reduction of PPI; whereas, s.c. haloperidol (0.5 mg/kg) totally reversed amphetamine-induced disruption of PPI. Caerulein's effect on PPI was blocked by pretreatment with a CCKA antagonist (devazepide) but not a CCKB antagonist (L-365,260). CCK-4, a preferential CCKB agonist, had no significant effect on PPI. These results suggest that caerulein produces a weak neuroleptic-like effect on PPI that is mediated by stimulation of CCKA receptors. Possible circuities in this effect are discussed. In a separate experiment, s.c. caerulein produced to a more potent neuroleptic-like profile on amphetamine-induced hyperlocomotion, suggesting that selection of preclinical paradigms may be important in evaluating the antipsychotic potential of CCK-based treatments. Department of Psychiatry, University of California, San Diego, La Jolla 92093-8620, USA. Feifel D D Reza T T Robeck S S eng Journal Article Research Support, Non-U.S. Gov't

UNITED STATES Neuropsychopharmacology 8904907 0006-3223 0 Antipsychotic Agents 0 Gastrointestinal Agents 0 Receptors, Cholecystokinin 17650-98-5 Caerulein 1947-37-1 Tetragastrin 52-86-8 Haloperidol 9011-97-6 Cholecystokinin IM Animals Antipsychotic Agents administration & dosage therapeutic use Behavior, Animal drug effects Caerulein therapeutic use Cholecystokinin physiology Gastrointestinal Agents therapeutic use Haloperidol administration & dosage therapeutic use Injections, Subcutaneous Male Motor Activity drug effects Psychotic Disorders drug therapy psychology Rats Rats, Sprague-Dawley Receptors, Cholecystokinin antagonists & inhibitors drug effects Startle Reaction drug effects Tetragastrin antagonists & inhibitors pharmacology 9929727 1999 04 28 1999 04 28 2004 11 17

0300-2896 34 11 1998 Dec Arch. Bronconeumol. [Tobacco control in children, adolescents and young people: knowledge, prevention and action]. 564 de Granda Orive J I JI Peña Miguel T T Morato Arnáiz A A spa Comment Letter La lucha contra el tabaco en los niños, adolescentes y jóvenes: conocimiento, prevención y actuación.

SPAIN Arch Bronconeumol 0354720 0300-2896 IM Arch Bronconeumol. 1998 Apr;34(4):199-203 9611655 Adolescent Adult Child Female Health Knowledge, Attitudes, Practice Humans Male Smoking prevention & control 10078868 1999 06 09 1999 06 09 2005 11 17

0041-0101 37 2 1999 Feb Toxicon Bibliography of toxinology. 399-404 eng Bibliography

ENGLAND Toxicon 1307333 0041-0101 0 Toxins, Biological IM Toxins, Biological 10083987 1999 05 11 1999 05 11 2004 11 17

0832-610X 46 2 1999 Feb Can J Anaesth Complete airway obstruction. 99-104 Crosby E T ET eng fre Comment Editorial

CANADA Can J Anaesth 8701709 0832-610X 0 Anesthetics, Local IM Can J Anaesth. 1999 Feb;46(2):176-8 10083999 Airway Obstruction etiology surgery Anesthesiology education Anesthetics, Local administration & dosage Cervical Vertebrae injuries Conscious Sedation adverse effects methods Humans Intubation, Intratracheal adverse effects instrumentation methods Laryngoscopes Laryngoscopy adverse effects methods Tracheostomy 10097079 1999 05 12 1999 05 12 2009 11 18

0027-8424 96 7 1999 Mar 30 Proc. Natl. Acad. Sci. U.S.A. Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species. 3578-83 The genome sequence of the extremely thermophilic archaeon Methanococcus jannaschii provides a wealth of data on proteins from a thermophile. In this paper, sequences of 115 proteins from M. jannaschii are compared with their homologs from mesophilic Methanococcus species. Although the growth temperatures of the mesophiles are about 50 degrees C below that of M. jannaschii, their genomic G+C contents are nearly identical. The properties most correlated with the proteins of the thermophile include higher residue volume, higher residue hydrophobicity, more charged amino acids (especially Glu, Arg, and Lys), and fewer uncharged polar residues (Ser, Thr, Asn, and Gln). These are recurring themes, with all trends applying to 83-92% of the proteins for which complete sequences were available. Nearly all of the amino acid replacements most significantly correlated with the temperature change are the same relatively conservative changes observed in all proteins, but in the case of the mesophile/thermophile comparison there is a directional bias. We identify 26 specific pairs of amino acids with a statistically significant (P < 0.01) preferred direction of replacement. Department of Microbiology, University of Illinois, B103 Chemical and Life Sciences Laboratory, 601 South Goodwin Avenue, Urbana, IL 61801, USA. Haney P J PJ Badger J H JH Buldak G L GL Reich C I CI Woese C R CR Olsen G J GJ eng GENBANK AF078607 AF078608 AF078609 AF078610 AF078611 AF078612 AF078613 AF078614 AF078615 AF078616 AF078617 AF078618 AF078619 AF078620 AF078621 AF078622 AF078623 AF078624 AF078625 AF078626 AF078627 AF078628 AF078629 AF078630 AF078631 AF078632 AF078633 AF078634 AF078635 AF078636 GM07283 GM NIGMS NIH HHS United States Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

UNITED STATES Proc Natl Acad Sci U S A 7505876 0027-8424 0 Bacterial Proteins IM S Biochemistry. 1991 Jul 23;30(29):7142-53 1854726 Biochemistry. 1991 Jan 15;30(2):589-94 1988046 Biochemistry. 1990 Aug 7;29(31):7133-55 2207096 J Mol Biol. 1990 Oct 5;215(3):403-10 2231712 Science. 1990 Mar 16;247(4948):1306-10 2315699 Biochemistry. 1990 Mar 6;29(9):2403-8 2337607 Proteins. 1989;5(1):22-37 2664764 Biochemistry. 1989 Sep 5;28(18):7205-13 2684274 J Mol Biol. 1989 Mar 20;206(2):397-406 2716053 Adv Protein Chem. 1988;39:191-234 3072868 J Mol Biol. 1988 Feb 5;199(3):525-37 3127592 Nature. 1988 Dec 15;336(6200):651-6 3200317 J Biol Chem. 1988 Mar 5;263(7):3086-91 3257756 Proc Natl Acad Sci U S A. 1986 Nov;83(21):8069-72 3464944 J Theor Biol. 1973 Jun;39(3):645-51 4354159 Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2056-60 9482837 Biochemistry. 1979 Dec 11;18(25):5698-703 518863 J Theor Biol. 1968 Nov;21(2):170-201 5700434 J Theor Biol. 1967 Aug;16(2):187-211 6048539 J Mol Biol. 1982 May 5;157(1):105-32 7108955 Eur J Biochem. 1982 Nov 15;128(2-3):565-75 7151796 Eur J Biochem. 1980 Jul;108(2):581-6 7408869 J Biochem. 1980 Dec;88(6):1895-8 7462208 Appl Environ Microbiol. 1995 Jul;61(7):2762-4 7618889 Eur J Biochem. 1995 May 1;229(3):688-95 7758464 J Mol Biol. 1995 Mar 3;246(4):511-21 7877172 J Mol Biol. 1994 Dec 2;244(3):332-50 7966343 Nat Genet. 1993 Mar;3(3):266-72 8485583 J Bacteriol. 1996 Feb;178(3):723-7 8550506 Structure. 1995 Nov 15;3(11):1147-58 8591026 Nucleic Acids Res. 1996 Jan 1;24(1):1-5 8594554 Biochemistry. 1996 Feb 27;35(8):2597-609 8611563 Protein Eng. 1995 Aug;8(8):779-89 8637847 Science. 1996 Aug 23;273(5278):1058-73 8688087 Protein Eng. 1996 Jan;9(1):27-36 9053899 Proteins. 1997 May;28(1):117-30 9144797 J Mol Biol. 1997 Jun 20;269(4):631-43 9217266 Gene. 1997 Dec 31;205(1-2):309-16 9461405 Proc Natl Acad Sci U S A. 1992 May 1;89(9):3751-5 1570293 Nature. 1975 May 15;255(5505):256-9 1143325 J Theor Biol. 1975 Mar;50(1):167-83 1127956 Science. 1974 Sep 6;185(4154):862-4 4843792 Crit Rev Biochem Mol Biol. 1991;26(1):1-52 1678690 Acclimatization Amino Acid Sequence Amino Acid Substitution Bacterial Proteins chemistry genetics Methanococcus genetics metabolism Molecular Sequence Data Protein Conformation Species Specificity Temperature PMC22336 NASA Discipline Exobiology Non-NASA Center Woese C R CR U IL, Urbana 10101342 1999 04 15 1999 04 15 2007 11 15

0733-8627 17 1 1999 Feb Emerg. Med. Clin. North Am. Evaluation of the patient with extremity trauma: an evidence based approach. 77-95, viii This article reviews relevant literature to provide evidence based guidelines for the evaluation of patients with extremity trauma in the emergency department. The development of clinical decision rules for extremity trauma in the ankle and knee, and guidelines for obtaining postreduction radiographs of shoulder dislocations and nursemaid's elbows are discussed. Division of Emergency Medicine, Northwestern University Medical School, Chicago, Illinois, USA. Kaufman D D Leung J J eng Journal Article

UNITED STATES Emerg Med Clin North Am 8219565 0733-8627 IM Ankle Injuries etiology radiography therapy Decision Support Techniques Emergencies Extremities injuries radiography Fractures, Bone etiology radiography therapy Humans Knee Injuries etiology radiography therapy Practice Guidelines as Topic Shoulder Dislocation etiology radiography therapy 10188493 1999 04 13 1999 04 13 2004 11 17

1354-5760 5 8 1998 Dec-1999 Jan Nurs Manag (Harrow) Women's health osteopathy: an alternative view. 6-9 Hyne J J eng Journal Article

ENGLAND Nurs Manag (Harrow) 9433248 1354-5760 N Female Great Britain Humans Osteopathic Medicine methods State Medicine Women's Health 10192114 1999 06 01 1999 06 01 2007 01 29

0031-7144 54 3 1999 Mar Pharmazie Antimicrobial activity of some Nepalese medicinal plants. 232-4 Institute of Pharmacy, Ernst-Moritz-Arndt-University, Greifswald, Germany. Rajbhandari M M Schöpke T T eng Journal Article Research Support, Non-U.S. Gov't

GERMANY Pharmazie 9800766 0031-7144 0 Anti-Bacterial Agents 0 Plant Extracts IM Anti-Bacterial Agents isolation & purification pharmacology Gram-Positive Bacteria drug effects Microbial Sensitivity Tests Nepal Plant Extracts pharmacology Plants, Medicinal chemistry 10192115 1999 06 01 1999 06 01 2007 01 29

0031-7144 54 3 1999 Mar Pharmazie Different kinetics of hydroquinone depletion in various medicinal plant tissue cultures producing arbutin. 234-5 Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic. Jahodár L L Dusková J J Polásek M M Papugová P P eng Journal Article

GERMANY Pharmazie 9800766 0031-7144 0 Hydroquinones 497-76-7 Arbutin IM Arbutin analysis biosynthesis Culture Techniques Flow Injection Analysis Hydroquinones analysis chemistry Kinetics Plants, Medicinal metabolism 10331748 1999 06 01 1999 06 01 2009 11 11

0031-9023 79 5 1999 May Phys Ther Looking for the Forrest. 454-5 Rothstein J M JM eng Editorial

UNITED STATES Phys Ther 0022623 0031-9023 AIM IM Empathy Humans Knowledge Physical Therapy Modalities Professional-Patient Relations Social Change Violence psychology 10331749 1999 06 01 1999 06 01 2009 11 11

0031-9023 79 5 1999 May Phys Ther Effects of side lying on lung function in older individuals. 456-66 Body positioning exerts a strong effect on pulmonary function, but its effect on other components of the oxygen transport pathway are less well understood, especially the effects of side-lying positions. This study investigated the interrelationships between side-lying positions and indexes of lung function such as spirometry, alveolar diffusing capacity, and inhomogeneity of ventilation in older individuals. Nineteen nonsmoking subjects (mean age=62.8 years, SD=6.8, range=50-74) with no history of cardiac or pulmonary disease were tested over 2 sessions. The test positions were sitting and left side lying in one session and sitting and right side lying in the other session. In each of the positions, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), single-breath pulmonary diffusing capacity (DLCO/VA), and the slope of phase III (DN2%/L) of the single-breath nitrogen washout test to determine inhomogeneity of ventilation were measured. Compared with measurements obtained in the sitting position, FVC and FEV1 were decreased equally in the side-lying positions, but no change was observed in DLCO/VA or DN2%/L. Side-lying positions resulted in decreases in FVC and FEV1, which is consistent with the well-documented effects of the supine position. These findings further support the need for prescriptive rather than routine body positioning of patients with risks of cardiopulmonary compromise and the need to use upright positions in which lung volumes and capacities are maximized. Family Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Manning F F Dean E E Ross J J Abboud R T RT eng Journal Article Research Support, Non-U.S. Gov't

UNITED STATES Phys Ther 0022623 0031-9023 AIM IM S Aged physiology Breath Tests Female Forced Expiratory Volume physiology Heart Diseases prevention & control Humans Lung Diseases prevention & control Male Middle Aged Posture physiology Predictive Value of Tests Pulmonary Diffusing Capacity physiology Spirometry Vital Capacity physiology 10389168 1999 07 15 1999 07 15 2006 11 15

0869-8139 85 1 1999 Jan Ross Fiziol Zh Im I M Sechenova [Ethanol modifies the ion selectivity of sodium channels in the rat sensory neurons]. 110-8 Ethanol was shown to decrease the reversal potential of tetrodotoxin-resistant (TTXr) and TTX-sensitive channels in short-term culture of the dorsal root ganglion cells. The ethanol led to alterations in ionic selectivity of the TTXr channels (its shifting from the X-th Eisenmann selectivity sequence to the XI-th one). The data obtained suggest that the findings were due to selectivity filter modification because of disturbed hydrogen bounds in the channel macromolecule. I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, Russia. Krylov B V BV Vilin Iu Iu IuIu Katina I E IE Podzorova S A SA rus English Abstract Journal Article Etanol modifitsiruet ionnuiu izbiratel'nost' natrievykh kanalov sensornykh neĭronov krysy.

RUSSIA Ross Fiziol Zh Im I M Sechenova 9715665 0869-8139 0 Cations 0 Sodium Channels 4368-28-9 Tetrodotoxin 64-17-5 Ethanol IM Animals Cations metabolism Cells, Cultured Ethanol pharmacology Ganglia, Spinal cytology Ion Channel Gating Neurons, Afferent drug effects metabolism Patch-Clamp Techniques Rats Rats, Wistar Sodium Channels drug effects Tetrodotoxin pharmacology 14796701 1951 12 01 2004 02 15 2008 11 21

0028-0836 166 4234 1950 Dec 23 Nature Reduction by molecular hydrogen of acetoacetate to butyrate by butyric acid bacteria. 1077-8 COHEN G N GN COHEN-BAZIRE G G eng Journal Article

Not Available Nature 0410462 0028-0836 0 Acetoacetates 107-92-6 Butyric Acid 541-50-4 acetoacetic acid OM Acetoacetates Bacteria Butyric Acid 5120:27591:5:76:156 ACETOACETIC ACID BACTERIA BUTYRIC ACID 14817685 1951 12 01 2004 02 15 2010 01 25

47 52 1950 Dec 29 Sven Lakartidn [The beriberi heart]. 3017-23 PALMBORG G G und Journal Article Om beriberihjärta.

Not Available Sven Lakartidn 0030130 OM Beriberi Heart Diseases 5120:49529:96:423 BERIBERI HEART IN VARIOUS DISEASES 13072632 1953 12 01 2003 05 01 2009 11 11

217 2 1953 Jan 5 Naunyn Schmiedebergs Arch Exp Pathol Pharmakol [Pharmacology of phosphoric acid esters; diethylthiophosphoric acid ester of ethylthioglycol]. 144-52 WIRTH W W und Journal Article Zur Pharmakologie der Phosphorsäureester; diathylthiophosphorsäureester des Athylthioglykol Systox-Wirkstoff.

Not Available Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 0054224 0 Insecticides 0 Phosphates OM Insecticides Phosphates 5324:43336:331:494 INSECTICIDES PHOSPHATES 13634534 1959 12 01 2000 07 01 2006 11 15

0014-2565 71 6 1958 Dec 31 Rev Clin Esp [Physiopathology of phosphorus and calcium changes and of bone lesions in glomerular nephropathies]. 365-77 LICHTWITZ A A DE SEZE S S PARLIER R R HIOCO D D BORDIER P P STRAUSS M M FERGOLA-MIRAVET L L spa Journal Article Fisiopatología de las modificaciones fosfocálcicas y de las lesiones óseas en las nefropatías glomerulares.

Not Available Rev Clin Esp 8608576 0014-2565 7440-70-2 Calcium 7723-14-0 Phosphorus OM Bone Diseases physiology Calcium metabolism Glomerulonephritis physiology Phosphorus metabolism 5936:8365:92:105:226:416 BONE DISEASES/physiology CALCIUM/metabolism GLOMERULONEPHRITIS/physiology PHOSPHORUS/metabolism 14177620 1964 11 01 1996 12 01 2006 11 15

0016-5662 68 1963 Dec 31 Gazz Int Med Chir [JEJUNAL BIOPSY AND LIPEMIA TOLERANCE TEST IN CIRRHOTIC PATIENTS]. SUPPL:4309-22 CESAREBASILE R R GABBRIELLI L L COLAVOLPE V V RULLI V V ita Journal Article BIOPSIA DIGIUNALE E LIPEMIA DA CARICO DEL CIRROTICO.

ITALY Gazz Int Med Chir 0373000 0016-5662 0 Chylomicrons 0 Lipids 0 Lipoproteins OM Ascites Chylomicrons Diabetes Mellitus Gastric Acidity Determination Gastritis Hepatitis A Jaundice Jejunum Lipid Metabolism Lipids blood Lipoproteins Liver Cirrhosis Malaria Pathology Pleurisy Protein Deficiency ASCITES BLOOD LIPIDS CHYLOMICRONS DIABETES MELLITUS GASTRIC ACIDITY DETERMINATION GASTRITIS HEPATITIS, INFECTIOUS JAUNDICE JEJUNUM LIPID METABOLISM LIPOPROTEINS LIVER CIRRHOSIS MALARIA PATHOLOGY PLEURISY PROTEIN DEFICIENCY 14316043 1965 10 01 1996 12 01 2010 05 11

0042-0255 59 1965 Dec-1966 Jan Univ Toronto Undergrad Dent J THE RESPONSIBILITY OF THE DENTIST AND THE DENTAL PROFESSION WITH RESPECT TO JAW FRACTURES. 5-11 PHILLIPS H H eng Journal Article

CANADA Univ Toronto Undergrad Dent J 7905911 0042-0255 D OM Dentists Fracture Fixation Fractures, Bone Interprofessional Relations Jaw Mandibular Injuries Maxillofacial Injuries Practice Management, Dental DENTISTS FRACTURE FIXATION FRACTURES INTERPROFESSIONAL RELATIONS JAW MANDIBULAR INJURIES MAXILLOFACIAL INJURIES PRACTICE MANAGEMENT, DENTAL 14337379 1965 12 01 1996 12 01 2005 11 16

0002-9378 93 1965 Oct 1 Am. J. Obstet. Gynecol. SEROTONIN CONTENT OF HUMAN PLACENTA AND FETUS DURING PREGNANCY. 411-5 KOREN Z Z PFEIFER Y Y SULMAN F G FG eng Journal Article

UNITED STATES Am J Obstet Gynecol 0370476 0002-9378 50-67-9 Serotonin OM Cesarean Section Fetus Histocytochemistry Metabolism Placenta Pregnancy Serotonin ABORTION CESAREAN SECTION FETUS HISTOCYTOCHEMISTRY METABOLISM PLACENTA PREGNANCY SEROTONIN 15611660 2005 03 01 2006 03 23 2006 11 15

1551-4005 4 1 2005 Jan Cell Cycle Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG. 3-5 Understanding the biological mechanisms underlying aging and cancer predisposition remains a fundamentally important goal in biomedicine. The generation of a PASG hypomorphic mutant mouse model shows that PASG, an SNF2 family member, is essential for properly maintaining normal DNA methylation and gene expression patterns. Disruption of PASG leads to decreased incorporation of BrdU, accumulation of senescence-associated tumor suppressor genes, and increased senescence-associated beta-galactosidase as well as age-related phenotypes. These observations demonstrate that PASG plays a critical role in maintenance of tissue homeostasis, normal growth and longevity. Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Sun Lin-Quan LQ Arceci Robert J RJ eng Journal Article 2005 01 03

United States Cell Cycle 101137841 1551-4005 59-14-3 Bromodeoxyuridine 9007-49-2 DNA EC 2.1.1.- Methyltransferases EC 3.2.1.23 beta-Galactosidase EC 3.6.1.- DNA Helicases EC 5.99.- Hells protein, mouse IM Animals Bromodeoxyuridine metabolism Cell Aging genetics Cell Cycle genetics physiology Cell Proliferation DNA metabolism DNA Helicases antagonists & inhibitors genetics physiology DNA Methylation Epigenesis, Genetic Gene Expression Regulation, Developmental Homeostasis genetics physiology Longevity genetics Methyltransferases physiology Mice Mice, Mutant Strains Mutation beta-Galactosidase metabolism 15611661 2005 03 01 2006 03 23 2009 11 19

1551-4005 4 1 2005 Jan Cell Cycle TrkAIII. A novel hypoxia-regulated alternative TrkA splice variant of potential physiological and pathological importance. 8-9 Nerve growth factor receptor TrkA is critical for development and maturation of central and peripheral nervous systems, regulating proliferation, differentiation and apoptosis. In cancer, TrkA frequently exhibits suppressor activity in nonmutated form and oncogenic activity upon mutation. Our identification of a novel hypoxia-regulated alternative TrkAIII splice variant, expressed by neural crest-derived neuroblastic tumors, that exhibits neuroblastoma tumor promoting activity, adds significantly to our understanding of potential TrkA involvement in cancer. Our observation that hypoxia, which characterizes the tumor micro-environment, stimulates alternative TrkAIII splicing, provides a way by which TrkA tumor suppressing signals may convert to tumor promoting signals during progression and is consistent with conservation and pathological subversion by neural crest-derived neuroblastic tumors of a mechanism of potential physiological importance to normal neural stem/neural crest progenitors. Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy. Tacconelli Antonella A Farina Antonietta R AR Cappabianca Lucia L Gulino Alberto A Mackay Andrew R AR eng Journal Article 2005 01 05

United States Cell Cycle 101137841 1551-4005 0 DNA, Neoplasm EC 2.7.10.1 Receptor, trkA IM Alternative Splicing Cell Differentiation genetics Cell Hypoxia Cell Line, Tumor Cell Proliferation DNA, Neoplasm genetics Gene Expression Regulation, Neoplastic Genetic Variation Humans Neoplastic Stem Cells pathology physiology Neural Crest cytology physiology Neuroblastoma genetics pathology physiopathology Receptor, trkA genetics physiology Signal Transduction genetics 15611667 2005 03 01 2006 03 23

1551-4005 4 1 2005 Jan Cell Cycle Replication timing of human chromosome 6. 172-6 Genomic microarrays have been used to assess DNA replication timing in a variety of eukaryotic organisms. A replication timing map of the human genome has already been published at a 1Mb resolution. Here we describe how the same method can be used to assess the replication timing of chromosome 6 with a greater resolution using an array of overlapping tile path clones. We report the replication timing map of the whole of chromosome 6 in general, and the MHC region in particular. Positive correlations are observed between replication timing and a number of genomic features including GC content, repeat content and transcriptional activity. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. Woodfine Kathryn K Beare David M DM Ichimura Koichi K Debernardi Silvana S Mungall Andrew J AJ Fiegler Heike H Collins V Peter VP Carter Nigel P NP Dunham Ian I eng Journal Article 2005 01 05

United States Cell Cycle 101137841 1551-4005 71-30-7 Cytosine 73-40-5 Guanine 9007-49-2 DNA IM Cell Line Chromosome Mapping Chromosomes, Human, Pair 6 genetics physiology Cytosine analysis DNA chemistry genetics DNA Repeat Expansion DNA Replication Timing Epigenesis, Genetic G1 Phase genetics physiology Gene Expression Regulation Guanine analysis Humans Major Histocompatibility Complex genetics Oligonucleotide Array Sequence Analysis methods S Phase genetics physiology Transcription, Genetic 15739502 2005 03 02 2010 04 15

1000-8713 15 5 1997 Sep Se Pu [The determination of olaquindox in feeds by HPLC]. 440-1 A liquid chromatographic procedure for the determination of olaquindox in feeds is described. Chromatography was performed on a PC8-10/S2504 (4.0 mm i.d. x 250 mm, 10 microm, Shimadzu Co.) column at 30 degrees C by using a mobile phase of methanol:water (20:80, V/V ) with a flow rate of 0.8 mL/min and UV detection at 260 nm. Acetanilide was used as internal standard. Olaquindox was extracted with dimethylformamide (DMF) from the feeds. The average recoveries of olaquindox were 98.58%-101.63% and the relative standard deviations were 2.67%-4.25%. The method is simple, rapid, reliable and inexpensive. Institute of Applied Chemistry, Nanchang University, Nanchang, 330047. Li L L Qiu S S chi English Abstract Evaluation Studies Journal Article Research Support, Non-U.S. Gov't

China Se Pu 9424804 1000-8713 0 Food Additives 0 Quinoxalines 23696-28-8 olaquindox IM Animal Feed analysis Chromatography, High Pressure Liquid methods Food Additives analysis Quinoxalines analysis 15810377 2005 04 06 2010 05 21

1000-0593 17 5 1997 Oct Guang Pu Xue Yu Guang Pu Fen Xi [Study on cleavage mechanisms of dimer (t-Bu)2NO in several solvent phases]. 124-7 In this paper, we studied the cleavage products of dimer t-BuNO in aqueous and organic solutions using method of 1HNMR and UV-Vis, analyzed the reactive kinetics, put forward that dimer (t-Bu)2NO homolytically cleavaged in nonpolar organic solution, and that dimer (t-Bu)2NO homolytically and heterolyticall cleavaged in a competitive manner in polar aqueous solution. Cancer Research Institute, Hunan Medical University, Changsha. Ma X X Tang J J chi English Abstract Journal Article

China Guang Pu Xue Yu Guang Pu Fen Xi 9424805 1000-0593 15968009 2005 06 21 2005 06 27 2007 11 14

1539-3704 142 12 Pt 1 2005 Jun 21 Ann. Intern. Med. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. 953-62 There is concern that exogenous female hormones may worsen disease activity in women with systemic lupus erythematosus (SLE). To evaluate the effect of hormone replacement therapy (HRT) on disease activity in postmenopausal women with SLE. Randomized, double-blind, placebo-controlled noninferiority trial conducted from March 1996 to June 2002. 16 university-affiliated rheumatology clinics or practices in 11 U.S. states. 351 menopausal patients (mean age, 50 years) with inactive (81.5%) or stable-active (18.5%) SLE. Interventions: 12 months of treatment with active drug (0.625 mg of conjugated estrogen daily, plus 5 mg of medroxyprogesterone for 12 days per month) or placebo. The 12-month follow-up rate was 82% for the HRT group and 87% for the placebo group. The primary end point was occurrence of a severe flare as defined by Safety of Estrogens in Lupus Erythematosus, National Assessment-Systemic Lupus Erythematosus Disease Activity Index composite. Severe flare was rare in both treatment groups: The 12-month severe flare rate was 0.081 for the HRT group and 0.049 for the placebo group, yielding an estimated difference of 0.033 (P = 0.23). The upper limit of the 1-sided 95% CI for the treatment difference was 0.078, within the prespecified margin of 9% for noninferiority. Mild to moderate flares were significantly increased in the HRT group: 1.14 flares/person-year for HRT and 0.86 flare/person-year for placebo (relative risk, 1.34; P = 0.01). The probability of any type of flare by 12 months was 0.64 for the HRT group and 0.51 for the placebo group (P = 0.01). In the HRT group, there were 1 death, 1 stroke, 2 cases of deep venous thrombosis, and 1 case of thrombosis in an arteriovenous graft; in the placebo group, 1 patient developed deep venous thrombosis. Findings are not generalizable to women with high-titer anticardiolipin antibodies, lupus anticoagulant, or previous thrombosis. Adding a short course of HRT is associated with a small risk for increasing the natural flare rate of lupus. Most of these flares are mild to moderate. The benefits of HRT can be balanced against the risk for flare because HRT did not significantly increase the risk for severe flare compared with placebo. Hospital for Joint Diseases, New York University School of Medicine, New York, New York, USA. jill.buyon@nyumc.org Buyon Jill P JP Petri Michelle A MA Kim Mimi Y MY Kalunian Kenneth C KC Grossman Jennifer J Hahn Bevra H BH Merrill Joan T JT Sammaritano Lisa L Lockshin Michael M Alarcón Graciela S GS Manzi Susan S Belmont H Michael HM Askanase Anca D AD Sigler Lisa L Dooley Mary Anne MA Von Feldt Joan J McCune W Joseph WJ Friedman Alan A Wachs Jane J Cronin Mary M Hearth-Holmes Michelene M Tan Mark M Licciardi Frederick F eng ClinicalTrials.gov NCT00000419 AR 43727 AR NIAMS NIH HHS United States M01 RR00052 RR NCRR NIH HHS United States M01 RR00096 RR NCRR NIH HHS United States U01 AR42540 AR NIAMS NIH HHS United States Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.

United States Ann Intern Med 0372351 0003-4819 0 Estrogens, Conjugated (USP) 520-85-4 Medroxyprogesterone AIM IM Ann Intern Med. 2005 Jun 21;142(12 Pt 1):1014-5 15968016 Ann Intern Med. 2005 Jun 21;142(12 Pt 1):I22 15968006 Adolescent Aged Aged, 80 and over Double-Blind Method Estrogen Replacement Therapy adverse effects Estrogens, Conjugated (USP) therapeutic use Female Follow-Up Studies Humans Lupus Erythematosus, Systemic physiopathology Medroxyprogesterone therapeutic use Middle Aged Postmenopause Risk Factors 16779244 2006 06 16 2007 02 15 2011 10 07

1942-597X 2005 AMIA Annu Symp Proc MeSH Speller + askMEDLINE: auto-completes MeSH terms then searches MEDLINE/PubMed via free-text, natural language queries. 957 Medical terminology is challenging even for healthcare personnel. Spelling errors can make searching MEDLINE/PubMed ineffective. We developed a utility that provides MeSH term and Specialist Lexicon Vocabulary suggestions as it is typed on a search page. The correctly spelled term can be incorporated into a free-text, natural language search or used as a clinical queries search. Office of High Performance Computing and Communications, National Library of Medicine, 8600 Rockville Pike, Bethesda, Maryland 20894, USA. Fontelo Paul P Liu Fang F Ackerman Michael M eng Z99 LM999999 LM NLM NIH HHS United States Journal Article

United States AMIA Annu Symp Proc 101209213 1559-4076 IM J Med Internet Res. 2003 Dec 11;5(4):e31 14713659 JAMA. 1998 Oct 21;280(15):1336-8 9794314 Information Storage and Retrieval methods Medical Subject Headings Natural Language Processing PubMed PMC1513542 16776646 2006 06 16 2006 08 09 2008 11 21

0248-4900 98 7 2006 Jul Biol. Cell Books for free? How can this be? - A PubMed resource you may be overlooking. 439-43 The NCBI (National Center for Biotechnology Information) at the National Institutes of Health collects a wide range of molecular biological data, and develops tools and databases to analyse and disseminate this information. Many life scientists are familiar with the website maintained by the NCBI (http://www.ncbi.nlm.nih.gov), because they use it to search GenBank for homologues of their genes of interest or to search the PubMed database for scientific literature of interest. There is also a database called the Bookshelf that includes searchable popular life science textbooks, medical and research reference books and NCBI reference materials. The Bookshelf can be useful for researchers and educators to find basic biological information. This article includes a representative list of the resources currently available on the Bookshelf, as well as instructions on how to access the information in these resources. Department of Biology, The Catholic University of America, Washington, DC 20064, USA. corsi@cua.edu Corsi Ann K AK eng Journal Article

England Biol Cell 8108529 0248-4900 IM Biological Science Disciplines Books Humans Internet National Library of Medicine (U.S.) PubMed Reference Books Reference Books, Medical Textbooks as Topic United States 16888359 2006 08 04 2006 09 28 2009 11 18

1064-3745 338 2006 Methods Mol. Biol. Mining microarray data at NCBI's Gene Expression Omnibus (GEO)*. 175-90 The Gene Expression Omnibus (GEO) at the National Center for Biotechnology Information (NCBI) has emerged as the leading fully public repository for gene expression data. This chapter describes how to use Web-based interfaces, applications, and graphics to effectively explore, visualize, and interpret the hundreds of microarray studies and millions of gene expression patterns stored in GEO. Data can be examined from both experiment-centric and gene-centric perspectives using user-friendly tools that do not require specialized expertise in microarray analysis or time-consuming download of massive data sets. The GEO database is publicly accessible through the World Wide Web at http://www.ncbi.nlm.nih.gov/geo. National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA. Barrett Tanya T Edgar Ron R eng Journal Article

United States Methods Mol Biol 9214969 1064-3745 IM Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13618-23 15353598 Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W213-6 15215383 Nucleic Acids Res. 2002 Jan 1;30(1):207-10 11752295 Science. 2003 Jun 13;300(5626):1749-51 12805549 Nucleic Acids Res. 2005 Jan 1;33(Database issue):D562-6 15608262 Nucleic Acids Res. 2005 Jan 1;33(Database issue):D39-45 15608222 PLoS Biol. 2004 Dec;2(12):e427 15562319 Methods Enzymol. 1996;266:141-62 8743683 J Mol Biol. 1990 Oct 5;215(3):403-10 2231712 Algorithms Animals Cluster Analysis Data Interpretation, Statistical Databases, Genetic Gene Expression Profiling statistics & numerical data Humans Information Storage and Retrieval Internet National Library of Medicine (U.S.) Oligonucleotide Array Sequence Analysis statistics & numerical data Software United States NIHMS12705 PMC1619899 16923641 2006 08 22 2007 01 25

0803-9488 60 4 2006 Nord J Psychiatry The use of PubMed/Medline in psychiatry. 3: Searching PubMed. 310-5 This paper is the third in a series of three, intended as a tutorial in the use of PubMed/Medline for an inexperienced user. The papers have the following contents: I--a description of NLM, Medline, PubMed and the system of Medical Subject Headings (MeSH), which form the basis for the indexing of scientific articles, books and other items at NLM. II--A description and a tutorial of the PubMed search window. III--The present article deals mainly with the searching for references in PubMed. Ways of restricting and concentrating the search are presented, and exercises are proposed. A reader may also find guidance for a search for medical books in the NLM Catalog, and in the use of tools like Related Articles, Bookshelf, and Index. With eating disorders as an example, more information is presented on the use of MeSH terms. Division of Psychiatry, Department of Clinical Neuroscience, Lund University, Sweden. sten.theander@med.lu.se Theander Sten S SS eng Journal Article Research Support, Non-U.S. Gov't

Norway Nord J Psychiatry 100927567 0803-9488 IM MEDLINE Medical Subject Headings Psychiatry PubMed 16949478 2006 09 04 2006 09 21

1558-3597 48 5 2006 Sep 5 J. Am. Coll. Cardiol. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). e247-346 European Heart Rhythm Association Heart Rhythm Society Zipes Douglas P DP Camm A John AJ Borggrefe Martin M Buxton Alfred E AE Chaitman Bernard B Fromer Martin M Gregoratos Gabriel G Klein George G Moss Arthur J AJ Myerburg Robert J RJ Priori Silvia G SG Quinones Miguel A MA Roden Dan M DM Silka Michael J MJ Tracy Cynthia C Smith Sidney C SC Jr Jacobs Alice K AK Adams Cynthia D CD Antman Elliott M EM Anderson Jeffrey L JL Hunt Sharon A SA Halperin Jonathan L JL Nishimura Rick R Ornato Joseph P JP Page Richard L RL Riegel Barbara B Priori Silvia G SG Blanc Jean-Jacques JJ Budaj Andrzej A Camm A John AJ Dean Veronica V Deckers Jaap W JW Despres Catherine C Dickstein Kenneth K Lekakis John J McGregor Keith K Metra Marco M Morais Joao J Osterspey Ady A Tamargo Juan Luis JL Zamorano José Luis JL American College of Cardiology American Heart Association Task Force European Society of Cardiology Committee for Practice Guidelines eng Journal Article Practice Guideline

United States J Am Coll Cardiol 8301365 0735-1097 0 Anti-Arrhythmia Agents AIM IM Anti-Arrhythmia Agents therapeutic use Cardiac Output, Low Cardiomyopathies complications Catheter Ablation Death, Sudden, Cardiac etiology prevention & control Defibrillators, Implantable Electrocardiography Heart Arrest etiology therapy Heart Function Tests Humans Tachycardia, Ventricular complications drug therapy physiopathology Ventricular Fibrillation complications drug therapy physiopathology 17059514 2006 10 24 2007 05 07

0269-2813 24 9 2006 Nov 1 Aliment. Pharmacol. Ther. Effectiveness of an 'half elemental diet' as maintenance therapy for Crohn's disease: A randomized-controlled trial. 1333-40 Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative therapy is needed for patients intolerant or resistant to thiopurines. To evaluate the effectiveness of home enteral nutrition as a maintenance therapy regimen in which half of the daily calorie requirement is provided by an elemental diet and the remaining half by a free diet. We refer to this home enteral nutrition therapy as 'half elemental diet'. Between 2002 and 2005, 51 patients in remission from two hospitals were randomly assigned to a half elemental diet group (n = 26) or a free diet group (n = 25). The primary outcome measure of this study was the occurrence of relapse over the 2-year period. The relapse rate in the half elemental diet group was significantly lower [34.6% vs. 64.0%; multivariate hazard ratio 0.40 (95% CI: 0.16-0.98)] than that in the free diet group after a mean follow-up of 11.9 months. Compliance was similar in the two groups. No adverse event occurred in any of the patients throughout the study. This randomized-controlled trial shows the effectiveness of an half elemental diet, which is a promising maintenance therapy for Crohn's disease patients. Division of Gastroenterology, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. stakagi@int3.med.tohoku.ac.jp Takagi S S Utsunomiya K K Kuriyama S S Yokoyama H H Takahashi S S Iwabuchi M M Takahashi H H Takahashi S S Kinouchi Y Y Hiwatashi N N Funayama Y Y Sasaki I I Tsuji I I Shimosegawa T T eng Journal Article Randomized Controlled Trial

England Aliment Pharmacol Ther 8707234 0269-2813 IM Adult Crohn Disease diet therapy Enteral Nutrition methods Female Follow-Up Studies Food, Formulated Humans Male Parenteral Nutrition methods Recurrence Treatment Outcome 17712873 2007 08 21 2007 08 22 2007 10 01

1432-2218 21 6 2007 Jun Surg Endosc Crura ultrastructural alterations in patients with hiatal hernia: a pilot study. 907-11 Unit of Surgical Digestive Physiopathology, Second University of Naples, via Pansini 5, I-80131 Naples, Italy. landino.fei@tin.it Fei L L del Genio G G Brusciano L L Esposito V V Cuttitta D D Pizza F F Rossetti G G Trapani V V Filippone G G Moccia F F Francesco M M del Genio A A eng Journal Article

Germany Surg Endosc 8806653 0930-2794 IM Surg Endosc. 2007 Aug;21(8):1473 Francesco, M [removed]; Moccia, F [added] Adult Biopsy Connective Tissue ultrastructure Diaphragm abnormalities ultrastructure Female Gastroesophageal Reflux etiology surgery Hernia, Hiatal etiology surgery Humans Male Microscopy, Electron, Transmission Middle Aged Muscle, Skeletal ultrastructure Recurrence 17713168 2007 08 23 2007 10 19 2007 11 30

1359-6535 12 5 2007 Antivir. Ther. (Lond.) Declining prevalence of HIV-1 drug resistance in treatment-failing patients: a clinical cohort study. 835-9 A major barrier to successful viral suppression in HIV type 1 (HIV-1)-infected individuals is the emergence of virus resistant to antiretroviral drugs. We explored the evolution of genotypic drug resistance prevalence in treatment-failing patients from 1999 to 2005 in a clinical cohort. Prevalence of major International AIDS Society-USA HIV-1 drug resistance mutations was measured over calendar years in a population with treatment failure and undergoing resistance testing. Predictors of the presence of resistance mutations were analysed by logistic regression. Significant reductions of the prevalence of resistance to all three drug classes examined were observed. This was accompanied by a reduction in the proportion of treatment-failing patients. Independent predictors of drug resistance were the earlier calendar year, prior use of suboptimal nucleoside analogue therapy, male sex and higher CD4 levels at testing. In a single clinical cohort, we observed a decrease in the prevalence of resistance to all three examined antiretroviral drug classes over time. If this finding is confirmed in multicentre cohorts it may translate into reduced transmission of drug-resistant virus from treated patients. Institute of Clinical Infectious Diseases, Catholic University, Rome, Italy. simona.digiambenedetto@rm.unicatt.it Di Giambenedetto Simona S Bracciale Laura L Colafigli Manuela M Colatigli Manuela M Cattani Paola P Pinnetti Carmen C Pannetti Carmen C Bacarelli Alessandro A Prosperi Mattia M Fadda Giovanni G