Skip Navigation Bar

Leasing Toxicological, Chemical and Directory Data

Content and Specifications
CCRIS, ChemIDplus Subset, DIRLINE®, GENE-TOX, HSDB® Subset, and TOXLINE® Subset
Click on each database name above for a description of that database. All are available for distribution in XML format via ftp.

Special note for ChemIDplus Subset: ChemIDplus structure and toxicity data available online at NLM are not available for distribution to licensees, nor does it include data with the source tag of USPDDN available in the web versions of ChemIDplus. Contact Terri Markward ( of the U.S. Pharmacopeial Convention, Inc., the provider of USPDDN data for ChemIDplus, for information about leasing USPDDN data directly from USP.

Special note for TOXLINE Subset: This database consists of various subfiles. The only one with restrictions is the IPA archival subfile (NLM does not currently add IPA data to TOXLINE Subset). The American Society of Health-System Pharmacists (ASHP) was the producer of IPA, which has since been acquired by Thomson Reuters. A special arrangement between Thomson Reuters and NLM's licensees is required before NLM may distribute IPA data. TOXLINE Subset licensees who wish to obtain this subfile from NLM should contact Thomson Reuters (; telephone: 800.336.4474). Any exception to the restrictions will be made by the data supplier. If you wish to receive IPA data, you should inform NLM that your arrangements have been made when the license paperwork is first submitted and again when your license profile is updated each subsequent year.

Special note for HSDB® Subset: Emergency Medical Treatment (EMT) information which contains portions of the POISINDEX┬« and MEDITEXT databases is not available for distribution to licensees. To obtain this information, contact Truven Health Analytics at

Sample NLM Data
Sample data is available for prospective NLM data licensees. A license agreement is not needed for sample data.

How to Lease
NLM leases CCRIS, ChemIDplus Subset, DIRLINE®, GENE-TOX, HSDB® Subset and TOXLINE® Subset to U.S. and non-US individuals or organizations.

To request a license, complete and submit the License Request Form after reading and accepting the electronic License Agreement for NLM Data.

Alternative to Leasing
CCRIS, GENE-TOX, HSDB Subset, ChemIDplus Subset, and TOXLINE Subset records may be downloaded from the Toxicology Data Network (TOXNET). DIRLINE records may be downloaded from DIRLINE: Directory of Health Organizations