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The view of alcoholism as a single disorder arising from purely environmental causes or the result of "moral" weakness has been changing rapidly in light of recent evidence concerning genetic factors that predispose the development of alcoholism. Working with animal models of alcohol tolerance and dependence, intramural scientists of the National Institute on Alcohol Abuse and Alcoholism have been able to investigate the addictive process at the cellular and subcellular levels. Clinical studies using recently developed classifications of alcoholics are beginning to yield results about the differing contributions of environmental and biologic factors.
c. 1980
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