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The 1902 Biologics Control Act authorized the Hygienic Laboratory to inspect firms producing vaccines, and grant licenses to those that met rigorous standards of cleanliness and product purity. The technique to produce diphtheria antitoxin was first announced in Europe in the fall of 1894. This bottle of diphtheria antitoxin, produced by the Hygienic Laboratory and dated May 8, 1895, is the oldest known sample in the United States. It is being preserved at the Smithsonian Institution's National Museum of American History.
1895
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