Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.
A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.
- Weight loss
- Muscle weakness
- Fatigue that gets worse over time
- Low blood pressure
- Patchy or dark skin
Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.
NIH: National Institute of Diabetes and Digestive and Kidney Diseases
- Addison's Disease (American Academy of Family Physicians) Available in Spanish
- Addison's Disease (Mayo Foundation for Medical Education and Research)
- Adrenal Insufficiency (Hormone Health Network) - PDF Available in Spanish
- Adrenal Insufficiency (Addison's Disease) (UpToDate)
- Adrenal Insufficiency and Addison's Disease (National Institute of Diabetes and Digestive and Kidney Diseases)
- Managing Adrenal Insufficiency (National Institutes of Health, Clinical Center) - PDF
- Genetics Home Reference: Autoimmune Addison disease (National Library of Medicine)
Journal ArticlesReferences and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Secondary adrenocortical insufficiency complicated by marked hypercalcemia and eosinophilia: a...
- Article: The contribution of online peer-to-peer communication among patients with adrenal...
- Article: A 12-year-old child with fever, headache, shock, and coma.
- Addison Disease -- see more articles
Find an Expert
- Directory of Endocrine and Metabolic Diseases Organizations (National Institute of Diabetes and Digestive and Kidney Diseases)
- Hormone Health Network
- National Institute of Diabetes and Digestive and Kidney Diseases
- 17-hydroxycorticosteroids Available in Spanish
- 24-hour urinary aldosterone excretion rate Available in Spanish
- ACTH (cosyntropin) stimulation test Available in Spanish
- ACTH blood test Available in Spanish
- Acute adrenal crisis Available in Spanish
- Addison's disease Available in Spanish
- Cortisol - urine Available in Spanish
- Cortisol level Available in Spanish