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Glyburide

(glye' byoor ide)

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Why is this medication prescribed?   Return to top

Glyburide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood), particularly in people whose diabetes cannot be controlled by diet alone. Glyburide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must produce insulin for this medication to work. Glyburide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?   Return to top

Glyburide comes in tablets to take by mouth. It is usually taken once a day with breakfast or twice a day (when a large daily dose is required). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glyburide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take glyburide even if you feel well. Do not stop taking glyburide without talking to your doctor.

What special precautions should I follow?   Return to top

Before taking glyburide,

What special dietary instructions should I follow?   Return to top

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet.

Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are taking glyburide.

What should I do if I forget a dose?   Return to top

Before you start taking glyburide, ask your doctor what to do if you forget to take a dose. Write these directions down so you can refer to them later.

As a general rule, take the missed dose as soon as you remember it unless it is almost time for the next dose. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?   Return to top

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:

If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.

Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of these symptoms:

Glyburide may cause side effects. If you experience any of the following symptoms, call your doctor immediately:

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?   Return to top

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose   Return to top

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?   Return to top

Studies have shown that people who take oral antidiabetic drugs have a higher rate of death caused by heart problems than people whose diabetes is treated with diet and insulin. Talk to your doctor about the possible risks, benefits, and alternatives of taking glyburide for your condition.

Keep all appointments with your doctor and the laboratory. Your blood sugar and glycosylated hemoglobin (HbA1c) should be checked regularly to determine your response to glyburide. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names   Return to top

  • Diabeta®
  • Glynase®
  • Micronase®

Brand names of combination products   Return to top

  • Glucovance® (containing Glyburide and Metformin)

Last Revised - 10/01/2007
Last Reviewed - 08/01/2007


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