MedlinePlus Drug Information: Glimepiride

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Other drug names:	A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9

Glimepiride

(glye' me pye ride)

Contents of this page:
Why is this medication prescribed? How should this medicine be used? What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose? What side effects can this medication cause?	What storage conditions are needed for this medicine? In case of emergency/overdose What other information should I know? Brand names

IMPORTANT WARNING: Return to top

Oral hypoglycemic drugs, including glimepiride, have been associated with increased cardiovascular mortality. Talk to your doctor about the possible risks, benefits, and alternatives of using this drug for your condition.

Why is this medication prescribed? Return to top

Glimepiride is used with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Glimepiride stimulates your pancreas to make more insulin and also makes your body more sensitive to insulin. Glimepiride may be used with or without insulin.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used? Return to top

Glimepiride comes as a tablet to take by mouth. It is usually taken once a day. The tablet should be taken with breakfast or the first big meal of the day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glimepiride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take glimepiride even if you feel well. Do not stop taking glimepiride without talking to your doctor.

What special precautions should I follow? Return to top

Before taking glimepiride,

tell your doctor and pharmacist if you are allergic to glimepiride or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), dexamethasone (Decadron), diuretics ('water pills'), estrogens, isoniazid (INH), MAO inhibitors [phenelzine (Nardil) and tranylcypromine (Parnate)], medications for high blood pressure or heart disease, niacin, oral contraceptives, phenytoin (Dilantin), prednisone, probenecid (Benemid), and vitamins.
tell your doctor if you have or have ever had kidney disease or ketoacidosis.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking glimepiride, call your doctor immediately.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking glimepiride.

What special dietary instructions should I follow? Return to top

Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthful diet.

Alcohol may cause a decrease in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are taking glimepiride.

What should I do if I forget a dose? Return to top

Take the missed dose as soon as you remember it. If you will be having a snack soon, take a dose with the snack. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause? Return to top

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

You may experience hypoglycemia (low blood sugar) while you are taking this medication. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:

shakiness
dizziness or lightheadedness
sweating
nervousness or irritability
sudden changes in behavior or mood
headache
numbness or tingling around the mouth
weakness
pale skin
hunger
clumsy or jerky movements

If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.

confusion
seizures
loss of consciousness

Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):

extreme thirst
frequent urination
extreme hunger
weakness
blurred vision

If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of the these symptoms:

dry mouth
upset stomach and vomiting
shortness of breath
breath that smells fruity
decreased consciousness

Glimepiride may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine? Return to top

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose Return to top

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know? Return to top

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to glimepiride. Your doctor will also tell you how to check your response to this medication by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to be sure you get proper treatment in an emergency.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names Return to top

Amaryl®

Last Revised - 05/01/2007
Last Reviewed - 08/01/2007

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS^® Consumer Medication Information. © Copyright, 2008. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.