Anagrelide is used to decrease the number of platelets (a type of blood cell that is needed to control bleeding) in the blood of patients who have a bone marrow disorder, in which the body makes too many of one or more types of blood cells, such as essential thrombocythemia (condition in which the body makes too many platelets) or polycythemia vera (condition in which the body makes too many red blood cells and sometimes too many platelets). Anagrelide is in a class of medications called platelet-reducing agents. It works by slowing the production of platelets in the body.
Anagrelide comes as a capsule to take by mouth. It is usually taken with or without food two to four times a day. Take anagrelide at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take anagrelide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Your doctor will probably start you on a low dose of anagrelide and gradually increase your dose, not more often than once a week. Your doctor may change your dose during your treatment based upon your body's response to the medication. Follow these directions carefully.
Anagrelide may help control your condition but will not cure it. Continue to take anagrelide even if you feel well. Do not stop taking anagrelide without talking to your doctor. If you suddenly stop taking anagrelide, the number of platelets in your blood will increase and you may experience symptoms.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
loss of appetite
difficulty falling asleep or staying asleep
lack of energy or sleepiness
muscle, joint or back pain
ringing in the ears
unusual bleeding or bruising
blood in urine or stool
black or tarry stools
fluttering sensation in the chest
fast, forceful, or irregular heartbeats
swelling of the arms, hands, feet, ankles or lower legs
slow or difficult speech
weakness or numbness of an arm or leg
pain, burning, or tingling in the hands or feet
changes in vision
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light or excess heat and moisture (not in the bathroom).Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
unusual bleeding or bruising
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to anagrelide.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Reviewed - 09/01/2010
AHFS® Consumer Medication Information. © Copyright, 2013. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.