Skip navigation
MedlinePlus Trusted Health Information for You U.S. National Library of MedicineNational Institutes of Health
Contact Us FAQs Site Map About MedlinePlus
español Home Health Topics Drugs & Supplements Medical Encyclopedia Dictionary News Directories Other Resources

Other drug names:  A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z  0-9

Diphenhydramine Topical

(dye fen hye' dra meen)

Printer-friendly versionE-mail this page to a friend

Contents of this page:

Why is this medication prescribed?   Return to top

Diphenhydramine, an antihistamine, is used to relieve the itching of insect bites, sunburns, bee stings, poison ivy, poison oak, and minor skin irritation.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?   Return to top

Diphenhydramine topical comes in cream, lotion, gel, and spray to be applied to the skin. It is used three or four times a day. Follow the directions on the package or on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use diphenhydramine exactly as directed. Do not use more or less of it or use it more often than directed by your doctor.

Thoroughly clean the infected area, allow it to dry, and then gently rub the medication in until most of it disappears. Use just enough medication to cover the affected area. You should wash your hands after applying the medication.

Do not apply diphenhydramine on chicken pox or measles, and do not use it on a child younger than 2 years of age unless directed to do so by a doctor.

What special precautions should I follow?   Return to top

Before using diphenhydramine,

What should I do if I forget a dose?   Return to top

Apply the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not apply a double dose to make up for a missed one.

What side effects can this medication cause?   Return to top

Diphenhydramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

What storage conditions are needed for this medicine?   Return to top

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). The spray is flammable. Keep it away from flames and extreme heat. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information should I know?   Return to top

Keep all appointments with your doctor. Diphenhydramine is for external use only. Do not let diphenhydramine get into your eyes, nose, or mouth, and do not swallow it. Do not apply dressings, bandages, cosmetics, lotions, or other skin medications to the area being treated unless your doctor tells you.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

Tell your doctor if your skin condition becomes severe or does not go away.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names   Return to top

  • Benadryl® Itch
  • Benadryl® Itch Stopping Cream Extra Strength
  • Benadryl® Itch Stopping Cream Original Strength
  • Benadryl® Itch Stopping Extra Strength Spray
  • Benadryl® Itch Stopping Gel Extra Strength
  • Benadryl® Itch Stopping Gel Original Strength
  • Benadryl® Itch Stopping Original Strength Spray
  • Dermamycin®

Brand names of combination products   Return to top

  • Dermamycin® Spray (containing Diphenhydramine Hydrochloride and Menthol)
  • Dermarest® Maximum Strength (containing Diphenhydramine Hydrochloride and Resorcinol)
  • Dermarest® Plus (containing Diphenhydramine Hydrochloride and Menthol)
  • Di-Delamine® (containing Diphenhydramine Hydrochloride and Tripelennamine)

Last Reviewed - 09/01/2008


ASHP Logo
American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS® Consumer Medication Information. © Copyright, 2009. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.