Prazosin and polythiazide is no longer available in the U.S. If you are currently taking prazosin and polythiazide, you should call your doctor to discuss switching to another treatment.
Prazosin and polythiazide should not be the first medicine you use for high blood pressure. Your medications must be carefully adjusted to treat high blood pressure. If you have not been on any medication for high blood pressure before prazosin and polythiazide, check with your doctor again before taking it.
The combination of prazosin and polythiazide is used to treat high blood pressure. It is a combination of two medicines. Prazosin, an alpha-block antihypertensive, works by relaxing blood vessels so that blood can flow more easily through the body. Polythiazide, a thiazide diuretic ('water pill'), causes the kidneys to get rid of unneeded water and salt from the body into the urine.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
The combination of prazosin and polythiazide comes as a capsule to take by mouth. It is usually taken two to three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take prazosin and polythiazide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
The combination of prazosin and polythiazide controls high blood pressure but does not cure it. Continue to take prazosin and polythiazide even if you feel well. Do not stop taking prazosin and polythiazide without talking to your doctor.
Follow your doctor's directions. They may include following a daily exercise program or a low-salt or low-sodium diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Check with your doctor if you have missed two or more doses.
ringing in the ears
thirst or dry mouth
cramps or muscle pain
decreased or increased urination
loss of appetite
decreased sexual ability or interest
sore throat with fever
unusual bleeding or bruising
severe skin rash with peeling skin
yellowing of the skin or whites of the eyes
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to prazosin and polythiazide.
Before having laboratory tests, tell your doctor and the laboratory personnel that you are taking prazosin and polythiazide. This drug interferes with some laboratory tests.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 11/15/2014
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.