Rizatriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Rizatriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and stopping the release of certain natural substances that cause pain, nausea, and other symptoms of migraine. Rizatriptan does not prevent migraine attacks.
Rizatriptan comes as a tablet and an orally disintegrating tablet to take by mouth. It should be taken at the first sign of a migraine headache. If you are at risk for heart disease and you have never taken rizatriptan before, you may need to take the first dose in your doctor's office. Usually only one dose is needed. If pain is not relieved with the first dose, your doctor may prescribe a second dose to be taken 2 hours after the first dose. Do not take more than 30 mg of rizatriptan in any 24-hour period. If you are also taking propranolol (Inderal), you should not take more than 15 mg of rizatriptan in any 24-hour period. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rizatriptan exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.
The orally disintegrating tablet should not be removed from the package until just before it is taken. The packet should be opened with dry hands, and the orally disintegrating tablet should be placed on the tongue, where it will dissolve and be swallowed with saliva.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Rizatriptan is not for routine use. Use it only to relieve a migraine headache as soon as symptoms appear.
tingling or numb feeling
muscle pain or cramps
flushing (feeling of warmth)
chest pain, tightness, or heaviness
fast or irregular heartbeats
throat pain or tightness
redness, swelling, or itching of the eyelids, face, or lips
changes in vision
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Do not remove tablets from the blister pack until just before use. Store the medication at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Keep all appointments with your doctor and the laboratory.
Read the patient information that comes with your prescription before you begin to take rizatriptan, and read it again every time you have your prescription filled in case the patient information changes.
Call your doctor if you continue to have migraine headache symptoms after the first dose.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Reviewed - 09/01/2010
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.