Toremifene may cause QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome (an inherited condition in which a person is more likely to have QT prolongation) or you have or have ever had low levels of potassium or magnesium in your blood, an irregular heartbeat, heart failure, or liver disease. Tell your doctor and pharmacist if you are taking amitriptyline (Elavil); antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), or voriconazole (Vfend); clarithromycin (Biaxin, in Prevpac); erythromycin (E.E.S., E-Mycin, Erythrocin); granisetron (Kytril); haloperidol (Haldol); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for irregular heartbeat such as amiodarone (Cordarone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Procanbid, Pronestyl), quinidine, and sotalol (Betapace, Betapace AF); levofloxacin (Levaquin); nefazodone; ofloxacin; ondansetron (Zofran); telithromycin (Ketek); thioridazine; and venlafaxine (Effexor). If you experience any of the following symptoms, stop taking toremifene and call your doctor immediately: fast, pounding, or irregular heartbeat; fainting; loss of consciousness; or seizures.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to toremifene. Your doctor also may order electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take toremifene.
Talk to your doctor about the risks of taking toremifene.
Toremifene is used to treat breast cancer that has spread to other parts of the body in women who have experienced menopause ('change of life'; end of monthly menstrual periods). Toremifene is in a class of medications called nonsteroidal antiestrogens. It works by blocking the activity of estrogen (a female hormone) in the breast. This may stop the growth of some breast tumors that need estrogen to grow.
Toremifene comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take toremifene at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take toremifene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Do not eat grapefruit or drink grapefruit juice while you are taking this medicine.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
blurred or abnormal vision
sensitivity to light or seeing halos around lights
difficulty seeing at night
fading or yellowing of colors
swelling of the hands, feet, ankles, or lower legs
pelvic pain or pressure
unusual vaginal discharge
muscle pain or weakness
loss of appetite
Some people who took toremifene developed cancer of the lining of the uterus. There is not enough information to tell if toremifene caused these people to develop cancer. Talk to your doctor about the risks of taking this medication.
Toremifene may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
hallucinations (seeing things or hearing voices that do not exist)
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 09/15/2011
AHFS® Consumer Medication Information. © Copyright, 2015. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.