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Crizotinib

pronounced as(kriz oh' ti nib)

Why is this medication prescribed?

Crizotinib is used to treat certain types of non-small cell lung cancer that has spread to nearby tissues or to other parts of the body. Crizotinib is in a class of medications called kinase inhibitors. It works by blocking the action of a certain naturally occurring substance that may be needed to help cancer cells multiply.

How should this medicine be used?

Crizotinib comes as a capsule to take by mouth. It is usually taken with or without food twice a day. Take crizotinib at around the same times every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take crizotinib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not split, chew, or crush them. Do not touch capsules that are broken or crushed.

Your doctor may temporarily or permanently stop your treatment, decrease the dose, or tell you take your medication less often if you experience serious side effects of crizotinib. Tell your doctor how you are feeling during your treatment.

Continue to take crizotinib even if you feel well. Do not stop taking crizotinib without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

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This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

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Before taking crizotinib,

  • tell your doctor and pharmacist if you are allergic to crizotinib, any other medications, or any of the ingredients in crizotinib capsules. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antibiotics such as clarithromycin (Biaxin); certain antifungal medications such as itraconaozole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); chloroquine (Aralen); chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); droperidol (Inapsine); ergotamine (Ergomar, in Cafergot, in Migergot); erythromycin (E.E.S., Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); flecainide (Tambocor); certain medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, and phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Pronestyl); quinidine (in Nuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, in Rifater); sirolimus (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); and vandetanib (Caprelsa). Many other medications may also interact with crizotinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor what herbal products you are taking, especially St. John's wort.
  • tell your doctor if you have or have ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow heartbeat, heart failure, or liver or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use birth control so that you or your partner will not become pregnant during your treatment with crizotinib and for 90 days after your treatment. Talk to your doctor about which method of birth control you should use. If you become pregnant while taking crizotinib, call your doctor immediately.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking crizotinib.
  • you should know that crizotinib may cause vision problems, dizziness, and excessive tiredness. Do not drive a car or operate machinery until you know how this medication affects you.

What special dietary instructions should I follow?

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Do not eat grapefruit or drink grapefruit juice while taking this medication.

What should I do if I forget a dose?

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Take the missed dose as soon as you remember it. However, if it is less than 6 hours before you are scheduled to take your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

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Crizotinib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • diarrhea

  • constipation

  • stomach pain

  • sores in the mouth

  • change in ability to taste food

  • heartburn

  • headache

  • numbness, burning, or tingling in the hands or feet

  • difficulty falling asleep or staying asleep

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • shortness of breath

  • cough

  • fever

  • swelling of the arms, hands, feet, ankles, or lower legs

  • chest pain

  • slow heartbeat

  • rash

  • weakness

  • excessive tiredness

  • pain in the right upper part of the stomach

  • nausea

  • vomiting

  • yellowing of the skin or eyes

  • dark urine

  • itching

  • fever

  • unusual bleeding or bruising

  • double vision

  • blurred vision

  • sensitivity to light

  • seeing sudden flashes of light

  • seeing new or increased floaters (spots in your vision)

Crizotinib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].

What should I know about storage and disposal of this medication?

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Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

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In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

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Keep all appointments with your doctor and the laboratory. Your doctor will order a lab test before you begin your treatment to see whether your cancer can be treated with crizotinib and will also order certain lab tests during your treatment to check your body's response to crizotinib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

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  • Xalkori®

Last Revised - 06/15/2012

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AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.