For female patients:
Do not take mifepristone if you are pregnant or plan to become pregnant. Mifepristone can cause loss of the pregnancy. You must have a negative pregnancy test before starting treatment with mifepristone and before beginning treatment again if you stop taking it for more than 14 days. If you can become pregnant, you will need to avoid becoming pregnant during your treatment with mifepristone. You must use acceptable forms of birth control during your treatment and for at least 1 month after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable. If you think you are pregnant, you miss a menstrual period, or you have sex without using birth control while taking mifepristone or within 1 month after your treatment, call your doctor immediately.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to mifepristone.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with mifepristone and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Talk to your doctor about the risk(s) of taking mifepristone.
Mifepristone (Korlym) is used to treat hyperglycemia (high blood sugar) in people with a certain type of Cushing's syndrome in which the body makes too much cortisol (a hormone) and who have failed surgery or cannot have surgery to treat this condition. Mifepristone is in a class of medications called cortisol receptor blockers. It works by blocking the activity of cortisol.
Mifepristone is also available as another product (Mifeprex) that is used alone or in combination with another medication to end an early pregnancy. This monograph only gives information about mifepristone (Korlym) used to control hyperglycemia in people with a certain type of Cushing's syndrome. If you are using mifepristone to terminate a pregnancy, read the monograph entitled mifepristone (Mifeprex), which has been written about this product.
Mifepristone comes as a tablet to take by mouth. It is usually taken once a day with a meal. Take mifepristone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mifepristone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the tablets whole; do not split, chew, or crush them. Tell your doctor or pharmacist if you are not able to swallow the tablets whole.
Your doctor will start you on a low dose of mifepristone and gradually increase your dose, not more often than once every 2 to 4 weeks. If you stop taking mifepristone, call your doctor. Your doctor may have to start you again on the lowest dose of mifepristone and gradually increase your dose.
Mifepristone can control your condition but does not cure it. It may take 6 weeks or longer before you feel the full benefit of mifepristone. Continue to take mifepristone even if you feel well.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Do not eat grapefruit or drink grapefruit juice while you are taking this medication.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
joint or muscle pain
swelling of the hands, feet, ankles, or lower legs
loss of appetite
dizziness or lightheadedness
unusual tiredness or weakness
nervousness or irritability
muscle weakness, aches, or cramps
rapid, irregular, or pounding heartbeats
unexpected vaginal bleeding or spotting
shortness of breath
Mifepristone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking mifepristone.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Revised - 02/15/2014
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.