Trimetrexate glucuronate is no longer available in the U.S. If you are currently receiving trimetrexate glucuronate, you should call your doctor to discuss switching to another treatment.
It is important to remember to take trimetrexate with leucovorin as directed by your doctor. If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Call your doctor if you miss a dose.
Your doctor has ordered the drug trimetrexate to help treat your illness. The drug can be given by injection into a vein.
infections caused by the bacteria Pneumocystis carinii in patients that do not have a fully functioning immune system
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Trimetrexate resembles a normal nutrient needed for cell growth. The Pneumocystis bacteria and cancer cells take in trimetrexate, which then interferes with their growth. You also will be given the drug leucovorin with each trimetrexate treatment. Leucovorin replaces the same needed nutrient in normal cells. Pneumocystis bacteria and cancer cells cannot use leucovorin. Take leucovorin exactly as prescribed by your doctor.
loss of appetite or weight
painful urination or red urine
black, tarry stools
unusual bruising or bleeding
shortness of breath
yellowing of the skin or eyes
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/Safety/MedWatch] or by phone [1-800-332-1088].
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
The most common side effect of trimetrexate is a decrease in the number of blood cells. Your doctor may order tests before, during, and after your treatment to see if your blood cells are affected by the drug.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Last Reviewed - 09/01/2010
AHFS® Consumer Medication Information. © Copyright, 2014. The American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.