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Becaplermin Topical

(be kap' ler min)

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IMPORTANT WARNING:   Return to top

At this time, there is not enough information to tell if people who use becaplermin gel are more likely to develop cancer than people who do not use the medication. However, a study has shown that people who have used 3 or more tubes of becaplermin gel who have or develop cancer are more likely to die from the cancer than people who have cancer who have not used becaplermin gel.

Tell your doctor if you have or have ever had any type of cancer, especially a growth or a tumor near the ulcer that will be treated with becaplermin gel. Your doctor may tell you not to use becaplermin gel.

Talk to your doctor about the risks of using becaplermin gel.

Why is this medication prescribed?   Return to top

Becaplermin gel is used as part of a total treatment program to help heal ulcers (sores) of the foot, ankle, or leg in people who have diabetes. Becaplermin gel must be used along with good ulcer care including: removal of dead tissue by a medical professional; the use of special shoes, walkers, crutches, or wheelchairs to keep weight off the ulcer; and treatment of any infections that develop. Becaplermin cannot be used to treat ulcers that have been stitched or stapled. Becaplermin is a human platelet-derived growth factor, a substance naturally produced by the body that helps in wound healing. It works by helping to repair and replace dead skin and other tissues, attracting cells that repair wounds, and helping to close and heal the ulcer.

How should this medicine be used?   Return to top

Becaplermin comes as a gel to apply to the skin. It is usually applied once a day to the ulcer. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use becaplermin gel exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Using more gel than your doctor prescribed will not help your ulcer heal faster.

Your doctor will show you how to measure becaplermin gel and will tell you how much gel to apply. The amount of gel you will need depends on the size of your ulcer. Your doctor will examine your ulcer every 1-2 weeks, and may tell you to use less gel as your ulcer heals and grows smaller.

It may take up to 20 weeks for you to feel the full benefit of becaplermin gel. Continue to use becaplermin gel for as long as it is prescribed by your doctor, even if your ulcer appears to be healed. Your doctor will tell you when your ulcer is completely healed and no longer needs treatment with becaplermin gel.

Becaplermin gel is for use on the skin only. Do not swallow the medication. Do not apply the medication to any part of your body other than the ulcer that is being treated.

To apply becaplermin gel, follow these steps:

Other uses for this medicine   Return to top

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?   Return to top

Before using becaplermin gel,

What special dietary instructions should I follow?   Return to top

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?   Return to top

Skip the missed application and continue your regular application schedule. Do not apply extra gel to make up for a missed application.

What side effects can this medication cause?   Return to top

Becaplermin gel may cause side effects. Tell your doctor if this symptom is severe or does not go away:

Becaplermin gel may cause other side effects. Tell your doctor if you have any unusual problems while you are using this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/index.html] or by phone [1-800-332-1088].

What storage conditions are needed for this medicine?   Return to top

Keep this medication in the container it came in tightly closed, and out of reach of children. Keep it in the refrigerator at all times but do not freeze it. Do not use the gel after the expiration date marked at the bottom of the tube. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information should I know?   Return to top

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names   Return to top

  • Regranex®

Last Reviewed - 02/01/2009


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