What is it?
Horse chestnut is a plant. Its seed, bark, flower, and leaves are used to make medicine. Horse chestnut contains significant amounts of a poison called esculin and can cause death if eaten raw.
Be careful not to confuse aesculus hippocastanum (Horse chestnut) with aesculus californica (California buckeye) or aesculus glabra (Ohio buckeye). Some people call any of these plants horse chestnut. This information applies to aesculus hippocastanum.
Horse chestnut seed and leaf are used for treating varicose veins, hemorrhoids, and swollen veins (phlebitis).
Horse chestnut seed is used for diarrhea, fever, and enlarged prostate.
Horse chestnut seeds can be processed so that the active chemicals are separated out and concentrated. The resulting “extract” is used for treating a blood circulation problem called chronic venous insufficiency.
Horse chestnut leaf is used for eczema, menstrual pain, soft tissue swelling from bone fracture and sprains, cough, arthritis, and joint pain.
Horse chestnut branch bark is used for malaria and dysentery.
Some people apply horse chestnut branch bark to the skin for lupus and skin ulcers.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for HORSE CHESTNUT are as follows:
Likely effective for...
- Varicose veins and other circulatory problems (chronic venous insufficiency). Taking horse chestnut seed extract can reduce some symptoms of poor blood circulation, such as varicose veins, pain, tiredness, swelling in the legs, itching, and water retention.
Insufficient evidence to rate effectiveness for...
- Enlarged prostate.
- Menstrual pain.
- Soft tissue swelling from bone fracture and sprains, arthritis, joint pain, and other conditions.
- Other conditions.
More evidence is needed to rate horse chestnut for these uses.
Horse chestnut contains a substance that thins the blood. It also makes it harder for fluid to leak out of veins and capillaries and weakly promotes fluid loss through the urine to help prevent water retention (edema).
Horse chestnut is LIKELY SAFE for most people when a standardized seed extract product is used short-term. Standardized products have been tested to contain exact amounts of a verified chemical. Look for products which have had the toxic substance esculin removed. Horse chestnut products can sometimes cause side effects such as dizziness, headache, stomach upset, and itching.
Pollen from the horse chestnut flower can cause allergic reactions. Rectal (suppository) use of horse chestnut may cause inflammation and itching in the anal area.
Raw horse chestnut seed, bark, flower, and leaf are UNSAFE and can even cause death when taken by mouth. Signs of poisoning include stomach upset, kidney problems, muscle twitching, weakness, loss of coordination, enlarged eye pupils, vomiting, diarrhea, depression, paralysis, and stupor. Accidental ingestion of horse chestnut requires prompt medical attention. Children have been poisoned by drinking a tea made from the leaves and twigs or eating seeds.
Special precautions & warnings:
Pregnancy and breast-feeding: Taking the raw seed, bark, flower or leaf is UNSAFE and can lead to death. Not enough is known about the safety of using horse chestnut seed extract from which the poisonous esculin has been removed during pregnancy or breast-feeding. Stay on the safe side and avoid using horse chestnut if you are pregnant or nursing.
Diabetes: Horse chestnut might lower blood sugar. If you have diabetes, watch for signs of too low blood sugar (hypoglycemia) and check your blood sugar carefully.
Digestion problems: Horse chestnut seeds and bark can irritate the gastrointestinal (GI) tract. Don’t use it if you have bowel or stomach disorders.
Liver disease: There is one report of liver injury associated with using horse chestnut. If you have a liver condition, it’s best to avoid horse chestnut.
Latex allergy: People who are allergic to latex might also be allergic to horse chestnut.
Kidney disease: There is a concern that horse chestnut might make kidney disease worse. Don’t use it if you have kidney problems.
Be cautious with this combination.
Horse chestnut might have an effect like a water pill or "diuretic." Taking horse chestnut might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications for diabetes (Antidiabetes drugs)
Horse chestnut might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking horse chestnut along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Horse chestnut seed might slow blood clotting. Taking horse chestnut seed along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Herbs and supplements that might lower blood sugar
Horse chestnut might lower blood sugar. Taking it along with other herbs or supplements that also lower blood sugar might cause blood sugar to drop too low. Some of these herbs and supplements include alpha-lipoic acid, chromium, devil's claw, fenugreek, garlic, guar gum, Panax ginseng, psyllium, Siberian ginseng, and others.
Herbs and supplements that might slow blood clotting
Horse chestnut might slow blood clotting. Using it with other herbs that also slow blood clotting might increase the risk of bruising and bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, and others.
There are no known interactions with foods.
The following dose has been studied in scientific research:
- For poor blood circulation (chronic venous insufficiency): 300 mg of horse chestnut seed extract containing 50 mg of the active ingredient, aescin, twice daily.
Aescin, Aescine, Aesculus hippocastanum, Buckeye, Castaño de Indias, Châtaignier de Mer, Châtaignier des Chevaux, Chestnut, Escine, Faux-Châtaignier, Hippocastani Cortex, Hippocastani Flos, Hippocastani Folium, Hippocastani Semen, Hippocastanum Vulgare Gaertn, Marron Europeen, Marronnier, Marronnier Blanc, Marronnier Commun, Marronnier d'Inde, Marronnier des Chevaux, Pu, Spanish Chestnut, Venastat, Venostasin Retard, Venostat, White Chestnut.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).
To see all references for the Horse chestnut page, please go to http://www.nlm.nih.gov/medlineplus/druginfo/natural/1055.html.
- Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd..
- Comaish JS, Kersey PJ. Contact dermatitis to extract of horse chestnut (esculin). Contact Dermatitis 1980;6:150-1.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103:507-13.
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7.
- Popp W, Horak F, Jager S, et al. Horse chestnut (Aesculus hippocastanum) pollen: a frequent cause of allergic sensitization in urban children. Allergy 1992;47:380-3.
- Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
- Anon. Horse Chestnut. The Natural Pharmacist 2000. www.tnp.com/substance.asp?ID=62. (Accessed 24 June 2000).
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Bisler H, Pfeifer R, Kluken N, Pauschinger P. [Effects of horse-chestnut seed on transcapillary filtration in chronic venous insufficiency]. Dtsch Med Wochenschr 1986;111:1321-9.
- Diehm C, Vollbrecht D, Amendt K, Comberg HU. Medical edema protection-clinical benefit in patients with chronic deep vein incompetence. Vasa 1992;21:188-92.
Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse-chestnut seed extract in patients with chronic venous insufficiency. Lancet 1996;347:292-4.
- Greeske K, Pohlmann BK. Horse chestnut seed extract-an effective therapy principle in general practice. Drug therapy of chronic venous insufficiency. Fortschr Med 1996;114:196-200.
- Pittler MH, Ernst E. Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review. Arch Dermatol 1998;134:1356-60.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
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Last reviewed - 09/13/2011
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