What is it?
Glucosamine sulfate is a naturally occurring chemical found in the human body. It is in the fluid that is around joints. Glucosamine is also found in other places in nature. For example, the glucosamine sulfate that is put into dietary supplements is often harvested from the shells of shellfish. Glucosamine sulfate used in dietary supplements does not always come from natural sources. It can also be made in a laboratory.
Glucosamine sulfate is commonly used for arthritis. Scientists have studied it extensively for this use. It is most often used for a type of arthritis called osteoarthritis. This is the most common type of arthritis.
Over the years, people have tried glucosamine sulfate for a variety of other uses. For example, it has been tried for glaucoma and for weight loss. But glucosamine sulfate has not been adequately studied for these uses. There is no proof that glucosamine sulfate is beneficial for these conditions.
There are different forms of glucosamine including glucosamine sulfate, glucosamine hydrochloride, and N-acetyl-glucosamine. These different chemicals have some similarities; however, they may not have the same effects when taken as a dietary supplement. Most of the scientific research done on glucosamine has been done on glucosamine sulfate. The information on this page pertains to glucosamine sulfate. For information on the other forms of glucosamine, see the specific pages for each of them.
Dietary supplements that contain glucosamine often contain additional ingredients. These additional ingredients are frequently chondroitin sulfate, MSM, or shark cartilage. Some people think these combinations work better than taking just glucosamine sulfate alone. So far, researchers have found no proof that combining the additional ingredients with glucosamine adds any benefit.
Glucosamine is also in some skin creams used to control arthritis pain. These creams usually contain camphor and other ingredients in addition to glucosamine. Researchers believe that any pain relief people may experience from these creams is due to ingredients other than glucosamine. There is no evidence that glucosamine can be absorbed through the skin.
Some glucosamine sulfate products are not labeled accurately. In some cases, the amount of glucosamine actually in the product has varied from none to over 100% of the amount stated on the product’s label. Some products have contained glucosamine hydrochloride when glucosamine sulfate was listed on the label.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for GLUCOSAMINE SULFATE are as follows:
Likely effective for...
- Osteoarthritis. Most research on glucosamine sulfate has measured its effectiveness on osteoarthritis of the knee. However, there is some evidence that it might also help osteoarthritis of the hip or spine.
Some research suggests that glucosamine reduces pain of osteoarthritis in the knee about as well as the over-the-counter pain reliever acetaminophen (Tylenol). It also seems to reduce pain about as much as the nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (Motrin, Advil) and piroxicam (Feldene). However, there is a difference between glucosamine sulfate and these drugs in the time it takes to reduce pain. The NSAIDs, such as Motrin, Advil, and Feldene, relieve symptoms and reduce pain usually within about 2 weeks, but glucosamine sulfate takes about 4-8 weeks.
Glucosamine sulfate does not seem to decrease pain in everyone who takes it. Some people get no benefit. Some research shows that glucosamine sulfate might not work very well for people with more severe, long-standing osteoarthritis, or for people who are older or heavier.
In addition to relieving pain, glucosamine sulfate might also slow the breakdown of joints in people with osteoarthritis who take it long-term. Some researchers hope that glucosamine sulfate might keep osteoarthritis from getting worse as quickly as it otherwise might. There is some evidence that people who take glucosamine sulfate might be less likely to need total knee replacement surgery.
Insufficient evidence to rate effectiveness for...
- Painful bladder syndrome (Interstitial cystitis). Early research suggests that taking a specific product containing glucosamine sulfate, sodium hyaluronate, chondroitin sulfate, quercetin, and rutin (CystoProtek) four times daily for 12 months reduces symptoms of painful bladder syndrome.
- Knee pain. Early research shows that taking 1500 mg of glucosamine sulfate daily for 28 days does not reduce knee pain in athletes following a knee injury. However, it does seem to improve knee movement.
- Multiple sclerosis. Early research shows that taking 1000 mg of glucosamine sulfate by mouth daily for 6 months might reduce the relapse of multiple sclerosis.
- Temporomandibular joint (TMJ) arthritis. TMJ is the joint in the jaw that dentists often check for clicking and proper alignment. It can be a factor related to jaw pain, chewing, yawning, and talking. Some research shows that taking glucosamine sulfate works about as well as the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen (Motrin, Advil, etc) for relieving jaw pain. In some people, pain relief appears to continue for up to 90 days after glucosamine sulfate is discontinued. However, research suggests that when 1200 mg of glucosamine sulfate is taken by mouth daily for 6 months, TMJ pain and the ability to open the jaw are not improved.
- Weight loss.
More evidence is needed to rate glucosamine sulfate for these uses.
Glucosamine sulfate is a chemical found in the human body. It is used by the body to produce a variety of other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints.
Joints are cushioned by the fluid and cartilage that surround them. In some people with osteoarthritis, the cartilage breaks down and becomes thin. This results in more joint friction, pain, and stiffness. Researchers think that taking glucosamine supplements may either increase the cartilage and fluid surrounding joints or help prevent breakdown of these substances, or maybe both.
Some researchers think the “sulfate” part of glucosamine sulfate is also important. Sulfate is needed by the body to produce cartilage. This is one reason why researchers believe that glucosamine sulfate might work better than other forms of glucosamine such as glucosamine hydrochloride or N-acetyl glucosamine. These other forms do not contain sulfate.
Glucosamine sulfate is LIKELY SAFE when used appropriately by mouth in adults.
Glucosamine sulfate is POSSIBLY SAFE when injected into the muscle as a shot twice weekly for up to 6 weeks or when applied to the skin in combination with chondroitin sulfate, shark cartilage, and camphor for up to 8 weeks.
Glucosamine sulfate can cause some mild side effects including nausea, heartburn, diarrhea, and constipation. Uncommon side effects are drowsiness, skin reactions, and headache. These are rare.
Special precautions & warnings:
Pregnancy or breast-feeding: There is not enough reliable scientific information available to know if glucosamine sulfate is safe to take during pregnancy or while breast-feeding. Until more is known, do not take glucosamine sulfate while pregnant or breast-feeding.
Asthma: There is one report linking an asthma attack with taking glucosamine. It is not known for sure if glucosamine was the cause of the asthma attack. Until more is known, people with asthma should be cautious about taking products that contain glucosamine.
Diabetes: Some early research suggested that glucosamine sulfate might raise blood sugar in people with diabetes. However, more recent and more reliable research now shows that glucosamine sulfate does not seem to affect blood sugar control in people with type 2 diabetes. Glucosamine appears to be safe for most people with diabetes, but blood sugar should be monitored closely.
High cholesterol: Animal research suggests that glucosamine may increase cholesterol levels. In contrast, glucosamine does not seem to increase cholesterol levels in humans. However, some early research suggests that glucosamine might increase insulin levels. This might cause cholesterol levels to increase. To be cautious, if you take glucosamine sulfate and have high cholesterol, monitor your cholesterol levels closely.
High blood pressure: Early research suggests that glucosamine sulfate can increase insulin levels. This might cause blood pressure to increase. However, more reliable research suggests that glucosamine sulfate does not increase blood pressure. To be cautious, if you take glucosamine sulfate and have high blood pressure, monitor your blood pressure closely.
Shellfish allergy: Because some glucosamine sulfate products are made from the shells of shrimp, lobsters or crabs, there is concern that glucosamine products might cause allergic reactions in people who are allergic to shellfish. However, allergic reactions in people with shellfish allergy are typically caused by the meat of shellfish, not the shell. There are no reports of allergic reactions to glucosamine in people who are allergic to shellfish. There is also some information that people with shellfish allergy can safely take glucosamine products.
Surgery: Glucosamine sulfate might affect blood sugar levels and might interfere with blood sugar control during and after surgery. Stop taking glucosamine sulfate at least 2 weeks before a scheduled surgery.
Do not take this combination.
Warfarin (Coumadin) is used to slow blood clotting. There are several reports showing that taking glucosamine sulfate with or without chondroitin increases the effect of warfarin (Coumadin), making blood clotting even slower. This can cause bruising and bleeding that can be serious. Don't take glucosamine sulfate if you are taking warfarin (Coumadin). Many natural medicines can interact with warfarin (Coumadin).
Be cautious with this combination.
Medications for cancer (Antimitotic chemotherapy)
Some medications for cancer work by decreasing how fast cancer cells can copy themselves. Some scientists think that glucosamine sulfate might increase how fast tumor cells can copy themselves. Taking glucosamine sulfate along with some medications for cancer might decrease the effectiveness of these medications for cancer. Any person who is receiving chemotherapy should talk with their health provider before taking glucosamine sulfate.
Some of these medications are etoposide (VP16, VePesid), teniposide (VM26), and doxorubicin (Adriamycin).
Be watchful with this combination.
Acetaminophen (Tylenol, others)
There is some concern that taking glucosamine sulfate and acetaminophen (Tylenol, others) together might affect how well each works. However, more information is needed to know if this interaction is a big concern. For now, most experts say it is okay to use both together.
Medications for diabetes (Antidiabetes drugs)
There has been concern that glucosamine sulfate might increase blood sugar in people with diabetes. There was also the concern that glucosamine sulfate might decrease how well diabetes medications work. However, research now shows that glucosamine sulfate probably does not increase blood sugar in people with diabetes. Therefore, glucosamine sulfate probably does not interfere with diabetes medications. To be cautious, if you take glucosamine sulfate and have diabetes, monitor your blood sugar closely.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
The following doses have been studied in scientific research:
- Osteoarthritis: 1500 mg once daily or 500 mg three times daily.
- Temporomandibular joint (TMJ) arthritis: 500 mg three times daily.
2-Amino-2-Deoxy-Beta-D-Glucopyranose, 2-Amino-2-Deoxy-D-Glucose Sulfate, 2-amino-2-deoxyglucose sulfate, Amino Monosaccharide, Chitosamine, Chlorure de Potassium-Sulfate de Glucosamine, D-Glucosamine, D-Glucosamine Sulfate, D-Glucosamine Sulphate, G6S, Glucosamine, Glucosamine Potassium Sulfate, Glucosamine Sulfate 2KCl, Glucosamine Sulfate-Potassium Chloride, Glucosamine Sulphate, Glucosamine Sulphate KCl, Glucosamine-6-Phosphate, GS, Mono-Sulfated Saccharide, Poly-(1->3)-N-Acetyl-2-Amino-2-Deoxy-3-O-Beta-D-Glucopyranurosyl-4-(or 6-) Sul, Saccharide Mono-Sulfaté, Saccharide Sulfaté, Sulfate de Glucosamine, Sulfate de Glucosamine 2KCl, SG, Sulfated Monosaccharide, Sulfated Saccharide, Sulfato de Glucosamina.
Glucosamine Hydrochloride and N-Acetyl Glucosamine are different than Glucosamine Sulfate. For information on these different products, see the Glucosamine Hydrochloride and N-Acetyl Glucosamine listings.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).
To see all references for the Glucosamine sulfate page, please go to http://www.nlm.nih.gov/medlineplus/druginfo/natural/807.html.
- Vlad, S. C., LaValley, M. P., McAlindon, T. E., and Felson, D. T. Glucosamine for pain in osteoarthritis: why do trial results differ? Arthritis Rheum 2007;56:2267-2277. View abstract.
- Reginster, J. Y. The efficacy of glucosamine sulfate in osteoarthritis: financial and nonfinancial conflict of interest. Arthritis Rheum 2007;56:2105-2110. View abstract.
- Frestedt, J. L., Walsh, M., Kuskowski, M. A., and Zenk, J. L. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial. Nutr J 2008;7:9. View abstract.
- Wandel, S., Juni, P., Tendal, B., Nuesch, E., Villiger, P. M., Welton, N. J., Reichenbach, S., and Trelle, S. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ 2010;341:c4675. View abstract.
- Lee, Y. H., Woo, J. H., Choi, S. J., Ji, J. D., and Song, G. G. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int 2010;30:357-363. View abstract.
- Theoharides, T. C., Kempuraj, D., Vakali, S., and Sant, G. R. Treatment of refractory interstitial cystitis/painful bladder syndrome with CystoProtek--an oral multi-agent natural supplement. Can J Urol 2008;15:4410-4414. View abstract.
- Villacis, J., Rice, T. R., Bucci, L. R., El-Dahr, J. M., Wild, L., Demerell, D., Soteres, D., and Lehrer, S. B. Do shrimp-allergic individuals tolerate shrimp-derived glucosamine? Clin Exp Allergy 2006;36:1457-1461. View abstract.
- Ostergaard, K., Hviid, T., and Hyllested-Winge, J. L. [The effect of glucosamine sulphate on the blood levels of cholesterol or triglycerides--a clinical study]. Ugeskr Laeger 2007;169:407-410. View abstract.
- Cahlin, B. J. and Dahlstrom, L. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:760-766. View abstract.
- Shaygannejad, V., Janghorbani, M., Savoj, M. R., and Ashtari, F. Effects of adjunct glucosamine sulfate on relapsing-remitting multiple sclerosis progression: preliminary findings of a randomized, placebo-controlled trial. Neurol Res 2010;32:981-985. View abstract.
Ostojic, S. M., Arsic, M., Prodanovic, S., Vukovic, J., and Zlatanovic, M. Glucosamine administration in athletes: effects on recovery of acute knee injury. Res Sports Med 2007;15:113-124. View abstract.
- Rozendaal, R. M., Uitterlinden, E. J., van Osch, G. J., Garling, E. H., Willemsen, S. P., Ginai, A. Z., Verhaar, J. A., Weinans, H., Koes, B. W., and Bierma-Zeinstra, S. M. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial. Osteoarthritis Cartilage 2009;17:427-432. View abstract.
- Marti-Bonmati, L., Sanz-Requena, R., Rodrigo, J. L., Alberich-Bayarri, A., and Carot, J. M. Glucosamine sulfate effect on the degenerated patellar cartilage: preliminary findings by pharmacokinetic magnetic resonance modeling. Eur Radiol 2009;19:1512-1518. View abstract.
- Rovati LC, Giacovelli G, Annefeld N, and et al. A large, randomized, placebo-controlled, double-blind study of glucosamine sulfate vs piroxocam and vs their association on the kinetics of the symptomatic effect in knee osteoarthritis. Osteoarth Cartilage 1994;2(suppl 1):56.
- Nandhakumar J. Efficacy, tolerability, and safety of a multicomponent antiinflammatory with glucosamine hydrochloride vs glucosamine sulfate vs an NSAID in the treatment of knee osteoarthritis--a randomized, prospective, double-blind, comparative study. Integr Med Clin J 2009;8:32-38.
- Muller-Fassbender, H., Bach, G. L., Haase, W., Rovati, L. C., and Setnikar, I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2:61-69. View abstract.
- Towheed, T. E. and Anastassiades, T. P. Glucosamine therapy for osteoarthritis. J Rheumatol 1999;26:2294-2297. View abstract.
- Kreder, H. J. Glucosamine and chondroitin were found to improve outcomes in patients with osteoarthritis. J Bone Joint Surg Am 2000;82:1323. View abstract.
- Zhang, W., Nuki, G., Moskowitz, R. W., Abramson, S., Altman, R. D., Arden, N. K., Bierma-Zeinstra, S., Brandt, K. D., Croft, P., Doherty, M., Dougados, M., Hochberg, M., Hunter, D. J., Kwoh, K., Lohmander, L. S., and Tugwell, P. OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010;18:476-499. View abstract.
- Petersen, S. G., Beyer, N., Hansen, M., Holm, L., Aagaard, P., Mackey, A. L., and Kjaer, M. Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. Arch Phys Med Rehabil 2011;92:1185-1193. View abstract.
- Noack, W., Fischer, M., Forster, K. K., Rovati, L. C., and Setnikar, I. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage 1994;2:51-59. View abstract.
- Giordano N, Fioravanti A, Papakostas P, et al. The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Curr Ther Res Clin Exp 2009;70:185-196. View abstract.
- Zhu, Y., Zou, J., Xiao, D., Fan, H., Yu, C., Zhang, J., Yang, J., and Guo, D. Bioequivalence of two formulations of glucosamine sulfate 500-mg capsules in healthy male Chinese volunteers: an open-label, randomized-sequence, single-dose, fasting, two-way crossover study. Clin Ther 2009;31:1551-1558. View abstract.
- Bruyere O, Pavelka K, Rovati LC, et al. Total joint replacement after glucosamine sulphate treatment in knee osteoarthritis: results of a mean 8-year observation of patients from two previous 3-year, randomised, placebo-controlled trials. Osteoarthritis Cartilage 2008;16:254-60. View abstract.
- Bijlsma JWJ, Lafeber FPJG. Glucosamine sulfate in osteoarthritis: The jury is still out. Ann Intern Med 2008;148:315-6. View abstract.
- Rozendaal RM, Koes BW, van Osch GJVM, et al. Effect of glucosamine sulfate on hip osteoarthritis: A randomized trial. Ann Intern Med 2008;148:268-77. View abstract.
- Persiani S, Rotini R, Trisolino G, et al. Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose. Osteoarthritis Cartilage 2007;15:764-72. View abstract.
- Yue QY, Strandell J, Myrberg O. Concomitant use of glucosamine may potential the effect of warfarin. The Uppsala Monitoring Centre. Available at: www.who-umc.org/graphics/9722.pdf (Accessed 28 April 2008).
- Knudsen J, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: Case report and review of the literature and MedWatch database. Pharmacotherapy 2008;28:540-8. View abstract.
- Muniyappa R, Karne RJ, Hall G, et al. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes 2006;55:3142-50. View abstract.
- Tannock LR, Kirk EA, King VL, et al. Glucosamine supplementation accelerates early but not late atherosclerosis in LDL receptor-deficient mice. J Nutr 2006;136:2856-61. View abstract.
- Pham T, Cornea A, Blick KE, et al. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 2007;333:333-9. View abstract.
- Stumpf JL, Lin SW. Effect of glucosamine on glucose control. Ann Pharmacother 2006;40:694-8. View abstract.
- Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5. View abstract.
- Towheed TE, Maxwell L, Anastassiades TP, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2005;:CD002946. View abstract.
- Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Ann Pharmacother 2005;39:1080-7. View abstract.
- Qiu GX, Weng XS, Zhang K, et al. [A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride/sulfate in the treatment of knee osteoarthritis]. Zhonghua Yi Xue Za Zhi 2005;85:3067-70. View abstract.
- Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum 2007;56:555-67. View abstract.
- Theodosakis J. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol 2004;31:826. View abstract.
- Zhang W, Doherty M, Arden N, et al. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis 2005;64:669-81. View abstract.
- Towheed TE, Anastassiades TP, Shea B, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev 2001;1:CD002946. View abstract.
- McAlindon T. Why are clinical trials of glucosamine no longer uniformly positive? Rheum Dis Clin North Am 2003;29:789-801. View abstract.
- Cibere J, Kopec JA, Thorne A, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum 2004;51:738-45. View abstract.
- McAlindon T, Formica M, LaValley M, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med 2004;117:643-9. View abstract.
- Bruyere O, Pavelka K, Rovati LC, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 2004;11:138-43. View abstract.
- Gray HC, Hutcheson PS, Slavin RG. Is glucosamine safe in patients with seafood allergy (letter)? J Allergy Clin Immunol 2004;114:459-60. View abstract.
- Tannis AJ, Barban J, Conquer JA. Effect of glucosamine supplementation on fasting and non-fasting plasma glucose and serum insulin concentrations in healthy individuals. Osteoarthritis Cartilage 2004;12:506-11. View abstract.
- Weimann G, Lubenow N, Selleng K, et al. Glucosamine sulfate does not crossreact with the antibodies of patients with heparin-induced thrombocytopenia. Eur J Haematol 2001;66:195-9. View abstract.
- Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford) 2002;41:279-84. . View abstract.
- Rozenfeld V, Crain JL, Callahan AK. Possible augmentation of warfarin effect by glucosamine-chondroitin. Am J Health Syst Pharm 2004;61:306-307. View abstract.
- Towheed TE. Current status of glucosamine therapy in osteoarthritis. Arthritis Rheum 2003;49:601-4. View abstract.
- Guillaume MP, Peretz A. Possible association between glucosamine treatment and renal toxicity: comment on the letter by Danao-Camara. Arthritis Rheum 2001;44:2943-4. View abstract.
- Danao-Camara T. Potential side effects of treatment with glucosamine and chondroitin. Arthritis Rheum 2000;43:2853. View abstract.
- Cohen M, Wolfe R, Mai T, Lewis D. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol 2003;30:523-8.. View abstract.
- Yu JG, Boies SM, Olefsky JM. The effect of oral glucosamine sulfate on insulin sensitivity in human subjects. Diabetes Care 2003;26:1941-2. View abstract.
- Setnikar I, Rovati LC. Absorption, distribution, metabolism and excretion of glucosamine sulfate. A review. Arzneimittelforschung 2001;51:699-725. View abstract.
- Hoffer LJ, Kaplan LN, Hamadeh MJ, et al. Sulfate could mediate the therapeutic effect of glucosamine sulfate. Metabolism 2001;50:767-70.. View abstract.
- Braham R, Dawson B, Goodman C. The effect of glucosamine supplementation on people experiencing regular knee pain. Br J Sports Med 2003;37:45-9.. View abstract.
- Scroggie DA, Albright A, Harris MD. The effect of glucosamine-chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Arch Intern Med 2003;163:1587-90.. View abstract.
- Richy F, Bruyere O, Ethgen O, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med 2003;163:1514-22.. View abstract.
- Tallia AF, Cardone DA. Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam Pract 2002;15:481-4.. View abstract.
- Russell RL, Pacelli KA, Kennedy KA. The development of multiple drug resistance in EMT6 cells after treatment with Brefeldin A (B), Tunicamycin (T), Hypoxia (H), 2-deoxyglucose (D), or Glucosamine (G). FASEB J 1993;7:A690.
- Tiku ML, Narla H, Karry SK, et al. Glucosamine Inhibits Advanced Lipoxidation Reaction and Chemical Modification of Lipoproteins by Scavenging Reactive Carbonyl Intermediates. American College of Rheumatology Meeting; October 25-29, 2002. Abstract 11.
- Alvarez-Soria MA, Largo R, Diez-Ortego E, et al. Glucosamine Inhibits IL-1ß-induced NF-kappa B Activation in Human Osteoarthritic chondrocytes. American College of Rheumatology Meeting; October 25-29, 2002. Abstract 118.
- Ganu VA, Hu SI, Strassman J, et al. Inhibitors of N-glycosylation Reduce Cytokine-induced Production of Matrix Metalloproteinases, Nitric oxide, and PGE2 from Articular Chondrocytes: A Candidate Mechanism for the Chondroprotective Effects of d-Glucosamine. American College of Rheumatology Meeting; October 25-29, 2002. Abstract 616.
- Cibere J, Kopec JA, Thorne A, et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum 2004;51:738-45. View abstract.
- Du XL, Edelstein D, Dimmeler S, et al. Hyperglycemia inhibits endothelial nitric oxide synthase activity by post-translational modification at the Akt site. J Clin Invest 2001;108:1341-8. View abstract.
- Pavelka K, Gatterova J, Olejarova M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002;162:2113-23. View abstract.
- Bagasra O, Whittle P, Heins B, Pomerantz RJ. Anti-human immunodeficiency virus type 1 activity of sulfated monosaccharides: comparison with sulfated polysaccharides and other polyions. J Infect Dis 1991;164:1082-90. View abstract.
- Nowak A, Szczesniak L, Rychlewski T, et al. Glucosamine levels in people with ischaemic heart disease with and without type II diabetes. Pol Arch Med Wewn 1998;100:419-25. View abstract.
- Olszewski AJ, Szostak WB, McCully KS. Plasma glucosamine and galactosamine in ischemic heart disease. Atherosclerosis 1990;82:75-83. View abstract.
- Yun J, Tomida A, Nagata K, Tsuruo T. Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncol Res 1995;7:583-90. View abstract.
- Pouwels MJ, Jacobs JR, Span PN, et al. Short-term glucosamine infusion does not affect insulin sensitivity in humans. J Clin Endocrinol Metab 2001;86:2099-103. View abstract.
- Monauni T, Zenti MG, Cretti A, et al. Effects of glucosamine infusion on insulin secretion and insulin action in humans. Diabetes 2000;49:926-35. View abstract.
- Does glucosamine increase serum lipid levels and blood pressure? Pharmacist's Letter/Prescriber's Letter 2001;17:171115.
- Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomised, placebo-controlled trial. Lancet 2001;357:251-6. View abstract.
- Almada A, Harvey P, Platt K. Effects of chronic oral glucosamine sulfate on fasting insulin resistance index (FIRI) in non-diabetic individuals. FASEB J 2000;14:A750.
- Thie NM, Prasad NG, Major PW. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. J Rheumatol 2001;28:1347-55. View abstract.
- Shankar RR, Zhu JS, Baron AD. Glucosamine infusion in rats mimics the beta-cell dysfunction of non-insulin-dependent diabetes mellitus. Metabolism 1998;47:573-7. View abstract.
- Rossetti L, Hawkins M, Chen W, et al. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J Clin Invest 1995;96:132-40. View abstract.
- Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother 1998;32:574-9. View abstract.
- Setnikar I, Palumbo R, Canali S, et al. Pharmacokinetics of glucosamine in man. Arzneimittelforschung 1993;43:1109-13. View abstract.
- Forster K, Schmid K, Rovati L, et al. Longer-term treatment of mild-to-moderate osteoarthritis of the knee with glucosamine sulfate- a randomized controlled, double-blind clinical study. Eur J Clin Pharmacol 1996;50:542.
- Reichelt A. Efficacy and safety of intramuscular glucosamine sulfate in osteoarthritis of the knee. A randomised, placebo-controlled, double-blind study. Arzneimittelforschung 1994;44:75-80. View abstract.
- Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469-74. View abstract.
- Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7:110-4. View abstract.
- Lopes Vaz A. Double-blind, clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulphate in the management of osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8:145-9. View abstract.
- da Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis. Ann Pharmacother 1998;32:580-7. View abstract.
- Drovanti A, Bignamini AA, Rovati AL. Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: a placebo-controlled double-blind investigation. Clin Ther 1980;3:260-72. View abstract.
- McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000;283:1469-75. View abstract.
- Rindone JP, Hiller D, Collacott E, et al. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 2000;172:91-4. View abstract.
- Foerster KK, Schmid K, Rovati LC. Efficacy of glucosamine sulfate in osteoarthritis of the lumbar spine: a placebo-controlled, randomized, double-blind study. Am Coll Rheumatol 64th Ann Scientific Mtg, Philadelphia, PA: 2000;Oct 29- Nov 2:abstract 1613.
- Kim YB, Zhu JS, Zierath JR, et al. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes 1999;48:310-20. View abstract.
- Holmang A, Nilsson C, Niklasson M, et al. Induction of insulin resistance by glucosamine reduces blood flow but not interstitial levels of either glucose or insulin. Diabetes 1999;48:106-11. View abstract.
- Giaccari A, Morviducci L, Zorretta D, et al. In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia. Diabetologia 1995;38:518-24. View abstract.
- Balkan B, Dunning BE. Glucosamine inhibits glucokinase in vitro and produces a glucose-specific impairment of in vivo insulin secretion in rats. Diabetes 1994;43:1173-9. View abstract.
- Adams ME. Hype about glucosamine. Lancet 1999;354:353-4. View abstract.
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