What is it?
Blond psyllium is an herb. The seed and the outer covering of the seed (husk) are used to make medicine.
Blond psyllium is used as a laxative and for softening stools in people with hemorrhoids, anal fissures, and after anal surgery. It is also used for diarrhea, irritable bowel syndrome (IBS), ulcerative colitis, and dysentery. Other uses include high cholesterol, high blood pressure, diabetes, cancer, weight control, and serious renal disease.
Some people apply blond psyllium to the skin as a poultice for boils.
In food manufacturing, blond psyllium is used as a thickener or stabilizer in some frozen dairy desserts.
Some foods that contain blond psyllium carry a label that claims these foods, when consumed as part of a low-fat diet, may reduce the risk of heart disease. The FDA allows this claim if the food contains at least 1.7 grams of psyllium per serving. The key word in this claim is “may.” It is true that blond psyllium can help lower cholesterol levels; but there’s no proof yet that taking blond psyllium reduces the risk of developing heart disease. Despite its effectiveness in lowering cholesterol levels, blond psyllium has not yet been included in the stepwise approaches to dietary therapy such as the American Heart Association Step I or Step II diets for high cholesterol. Most clinical studies have used a specific blond psyllium powder preparation (Metamucil) or food that contains psyllium seed husk, such as cereals, breads, or snack bars.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for BLOND PSYLLIUM are as follows:
- Relieving constipation and softening stools. Some evidence suggests that blond psyllium alone can relieve constipation and improve stool consistency as effectively as preparations containing blond psyllium plus senna or docusate sodium.
Likely effective for...
- Lowering cholesterol in people with high cholesterol. Taking blond psyllium reduces cholesterol levels in people with mild to moderate high cholesterol. Blond psyllium seed husk or seed added to food or as a separate supplement in a dose of approximately 10-12 grams daily, in combination with a low-fat or a high-fat diet, can reduce levels of total cholesterol by 3% to 14% and low density lipoprotein (LDL) cholesterol by 5% to 10 after 7 weeks or more of treatment. Blond psyllium also does not seem to lower other blood fats called triglycerides.
In children with high cholesterol, taking psyllium can further decrease LDL cholesterol levels by 7% to 15% when added to a low-fat, low-cholesterol diet such as the National Cholesterol Education Program (NCEP) Step 1 diet. Interestingly, taking blond psyllium along with a stricter low-fat, low-cholesterol diet such as the NCEP Step 2 diet may have less of an additional effect in lowering LDL cholesterol.
Psyllium seems to be less effective in older people. There is some evidence that it lowers LDL cholesterol levels to a lesser degree in people 60 years or older compared to people under 60.
Some evidence suggests that psyllium seed might be more effective than the seed husk for lowering cholesterol.
Blond psyllium seems to be most effective when taken with foods at mealtime. Breakfast cereal containing blond psyllium can decrease total cholesterol and LDL cholesterol by 5% and 9%, respectively.
There is some evidence that taking blond psyllium for high cholesterol makes it possible to reduce the dose of certain medications used to lower cholesterol. For example, taking 15 grams of blond psyllium (Metamucil) along with 10 mg of simvastatin (Zocor) daily seems to lower cholesterol about as well as taking a higher dose (20 mg) of simvastatin daily. Similarly, a combination of blond psyllium with colestipol (Colestid) at half their usual doses seems to be as effective as colestipol alone. Blond psyllium also seems to reduce colestipol and cholestyramine (Questran, Questran Light, Cholybar) side effects such as constipation and abdominal pain. But don’t adjust the dose of your medication without consulting your healthcare provider.
Possibly effective for...
- Irritable bowel syndrome (IBS). While not all studies agree, there is evidence that blond psyllium seed husk can relieve constipation and improve abdominal pain, diarrhea, and overall well-being. It may take up to four weeks of treatment to get the best results.
- Lowering blood sugar after eating a meal in people with diabetes (type 1 and type 2). Blond psyllium's maximum effect on the blood sugar levels occurs when psyllium is mixed with or taken with foods. In addition to lowering blood sugar, blond psyllium seed husk also lowers cholesterol in people with diabetes who have high cholesterol. Some studies show blond psyllium can lower total cholesterol by about 9%, and LDL cholesterol by 13%. Blond psyllium does not lower after-meal blood sugar levels in people who do not have diabetes.
- High blood pressure. Taking psyllium fiber (husks) with soy protein seems to help reduce the top number in a blood pressure reading (systolic blood pressure) by about 8 mmHg and the bottom number (diastolic blood pressure) by about 2 mmHg in adult men and women.
- Treating side effects of a drug called Orlistat (Xenical, Alli). Taking blond psyllium with each dose of orlistat seems to relieve orlistat side effects such as gas, stomach rumbling, stomach cramps, and oily spotting without decreasing the weight-reducing effect of orlistat.
- Preventing ulcerative colitis symptoms.
Possibly ineffective for...
- Skin growths in the large intestine and rectum (colorectal adenoma). Taking 3.5 grams of blond psyllium per day does not seem to reduce the risk of colorectal adenoma. There is some evidence that it might actually increase the risk of adenoma recurrence, particularly in people who get a lot of calcium from their diet. However, more evidence is needed to determine the relationship of psyllium and calcium to colorectal adenoma.
- Serious kidney disease.
Insufficient evidence to rate effectiveness for...
- Preventing fat redistribution in people with HIV disease.
- Some types of cancer.
- Some types of skin conditions.
- Other conditions.
More evidence is needed to rate blonde psyllium for these uses.
The husks of the psyllium seed absorb water and form a large mass. In people with constipation, this mass stimulates the bowel to move. In people with diarrhea, it can slow down the bowel and reduce bowel movements.
Blond psyllium is LIKELY SAFE for most people when taken with plenty of fluids. Drink at least 8 ounces of fluids for every 3-5 grams of husk or 7 grams of seed. In some people, blond psyllium might cause gas, stomach pain, diarrhea, constipation, and nausea. It has also been linked to reports of headache, backache, runny nose, cough, and sinus problems.
Some people can have an allergic response to blond psyllium with symptoms such as swollen nasal passages, sneezing, swollen eyelids, hives, and asthma. Some people can also become sensitized to psyllium through exposure at work or repeated use of psyllium. Stop using blond psyllium and get medical attention immediately if you develop symptoms such as flushing, severe itching, shortness of breath, wheezing, swelling of the face or body, chest and throat tightness, or loss of consciousness.
Special precautions & warnings:
Pregnancy and breast-feeding: Blond psyllium is LIKELY SAFE when used appropriately.
Diabetes: Blond psyllium can lower blood sugar levels in people with type 2 diabetes. Monitor blood sugar levels closely. Doses of conventional antidiabetes medications may need adjustment. Another consideration is that some commercial blond psyllium products can contain added sugars that might increase blood sugar levels.
Gastrointestinal (GI) disorders: Don’t use blond psyllium if you tend to develop hard stools in the rectum due to ongoing constipation (fecal impaction), GI tract narrowing, obstruction, or conditions that can lead to obstruction, such as spastic bowel.
Allergy: Some patients can have severe hypersensitivity reactions to blond psyllium. This is more likely to occur in patients with previous occupational exposure to blond psyllium. Don’t use blond psyllium if you are sensitive to it.
Phenylketonuria: Some blond psyllium preparations are sweetened with aspartame (Nutrasweet) and should be avoided in patients with phenylketonuria.
Surgery: Blond psyllium might affect blood sugar levels, making blood sugar control more difficult during and after surgery. Stop taking blond psyllium at least 2 weeks before a scheduled surgery.
Swallowing disorders: Don’t use blond psyllium if you have problems swallowing. Blond psyllium might increase your risk of choking.
Be cautious with this combination.
Blond psyllium contains large amounts of fiber. Fiber can decrease how much carbamazepine (Tegretol) the body absorbs. By decreasing how much carbamazepine (Tegretol) the body absorbs blond psyllium might decrease the effectiveness of carbamazepine (Tegretol).
Blond psyllium contains large amounts of fiber. Fiber can decrease how much lithium the body absorbs. Taking lithium along with blond psyllium might decrease the effectiveness of lithium. To avoid his interaction take blond psyllium at least one hour after lithium.
Medications for diabetes (Antidiabetes drugs)
Blond psyllium might decrease blood sugar by decreasing the absorption of sugars from food. Diabetes medications are also used to lower blood sugar. Taking blond psyllium with diabetes medications might cause your blood sugar to be too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Warfarin (Coumadin) is used to slow blood clotting. Some people worry that blond psyllium may decrease warfarin (Coumadin) absorption and its effectiveness, which could increase the risk of clotting. But blond psyllium does NOT seem to affect warfarin (Coumadin) absorption or effectiveness.
Be watchful with this combination.
Blond psyllium is high in fiber. Fiber can decrease the absorption and decrease the effectiveness of digoxin (Lanoxin). As a general rule, any medications taken by mouth should be taken one hour before or four hours after blond psyllium to prevent this interaction.
Ethinyl estradiol is a form of estrogen that's in some estrogen products and birth control pills. Some people worry that psyllium can decrease how much ethinyl estradiol the body absorbs. But it is unlikely that psyllium will significantly affect ethinyl estradiol absorption.
Use of blond psyllium with iron supplements can reduce the amount of iron that the body absorbs. Take iron supplements one hour before or four hours after psyllium to avoid this interaction.
Psyllium seems to slightly reduce the amount of riboflavin that the body absorbs, but it's probably not important.
Psyllium can make dietary fat more difficult to digest and can increase the amount of fat lost is the stool when taken in combination with dietary fats such as soybean oil or coconut oil.
It’s important to take enough water when taking blond psyllium. Not taking enough fluid could lead to choking or obstruction of the esophagus (the food passage connecting the throat and the stomach) or bowel. Take at least 240 mL per 5 grams or less of blond psyllium husk or 7 grams of blond psyllium seed. To minimize some of the common GI side effects, start with a low dose and increase to the needed amount.
The following doses have been studied in scientific research:
- As a laxative for constipation: 7-40 grams of blond psyllium seed per day, in 2-4 divided doses.
- For diarrhea: 7-18 grams of blond psyllium, in 2-3 divided doses or 5 grams of a combination of blond psyllium, calcium carbonate, and calcium phosphate (in ratio of 4:1:1 by weight).
- For decreasing diarrhea in patients receiving tube feedings: up to 30 grams of blond psyllium daily in divided doses of 2.5-7.5 grams per dose. It may be given through the feeding tube, either mixed with the nutritional formula or all at once followed by a flush with water. However, use care, because psyllium might clog the feeding tube.
- For chronic diarrhea after gall bladder surgery: 6.5 grams of blond psyllium three times daily.
- For diarrhea that sometimes accompanies the use of a medicine called misoprostol: 3.4 grams of blond psyllium twice daily.
- For irritable bowel syndrome (IBS): 10-30 grams of blond psyllium seed husk in two to three divided doses daily. 10 grams of blond psyllium seed husk twice daily with 15 mg of propantheline three times daily has also been used.
- For reducing the gastrointestinal (GI) side effects of a medicine called orlistat: 6 grams of blond psyllium three times daily with each orlistat dose.
- For keeping symptoms of ulcerative colitis under control: 10 grams of blond psyllium seeds, taken twice daily.
- For relieving bleeding from hemorrhoids: 3.5 grams of psyllium seed husk, twice daily for three months.
- For high cholesterol: 3.4 grams of blond psyllium seed husk three times daily or 5.1 grams twice daily. However, doses up to 20.4 grams per day have been tried. Cereal with added psyllium that provides 12 grams of soluble fiber per day has also been used. A mixture of 2.1 grams of psyllium, 1.3 grams of pectin, 1.1 grams of guar gum and 0.5 grams of locust bean gum has been used three times daily. A combination of 2.5 grams of blond psyllium powder (Metamucil) with 2.5 grams of colestipol, taken three times daily has also been used. A combination of simvastatin (Zocor) 10 mg and blond psyllium (Metamucil) 15 grams daily has also been used. In children with high cholesterol: cereal containing 5-10 grams of psyllium daily.
- For type 2 diabetes and high cholesterol: 15 grams of blond psyllium in three divided doses.
- For reducing the glycemic index of food in patients with type 2 diabetes: 15 grams of blond psyllium in three divided doses with a carbohydrate meal has been used.
- For high blood pressure: 15 grams of blond psyllium husks daily for 8 weeks.
Balle de Psyllium, Blond Plantago, Blonde Psyllium, Che Qian Zi, Dietary Fiber, Englishman's Foot, Fibre Alimentaire, Indian Plantago, Ipágula, Isabgola, Isabgul, Ispaghul, Ispaghula, Ispagol, Pale Psyllium, Plantaginis Ovatae Semen, Plantaginis Ovatae Testa, Plantago decumbens, Plantago fastigiata, Plantago insularis, Plantago ispaghula, Plantago ovata, Psilio, Psillium Blond, Psyllium, Psyllium Blond, Psyllium Husk, Sand Plantain, Spogel.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).
To see all references for the Blond psyllium page, please go to http://www.nlm.nih.gov/medlineplus/druginfo/natural/866.html.
- Ganji V, Kies CV. Psyllium husk fibre supplementation to soybean and coconut oil diets of humans: effect on fat digestibility and faecal fatty acid excretion. Eur J Clin Nutr 1994;48:595-7.
- Moreyra AE, Wilson AC, Koraym A. Effect of Combining Psyllium Fiber With Simvastatin in Lowering Cholesterol. Arch Intern Med 2005;165:1161-6.
- Uribe M, Dibildox M, Malpica S, et al. Beneficial effect of vegetable protein diet supplemented with psyllium plantago in patients with hepatic encephalopathy and diabetes mellitus (abstract). Gastroenterology 1985;88:901-7.
- Florholmen J, Arvidsson-Lenner R, Jorde R, Burhol PG. The effect of Metamucil on postprandial blood glucose and plasma gastric inhibitory peptide in insulin-dependent diabetics (abstract). Acta Med Scand 1982;212:237-9.
- Sierra M, Garcia JJ, Fernandez N, et al. Therapeutic effects of psyllium in type 2 diabetic patients. Eur J Clin Nutr 2002;56:830-42.
- Hendricks KM, Dong KR, Tang AM, et al. High-fiber diet in HIV-positive men is associated with lower risk of developing fat deposition. Am J Clin Nutr 2003;78:790-5.
- Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7.
- Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5.
- FDA Talk Paper. FDA Allows Foods Containing Psyllium To Make Health Claim On Reducing Risk Of Heart Disease. 1998. Available at: http://www.fda.gov/bbs/topics/ANSWERS/ANS00850.html.
- Burke V, Hodgson JM, Beilin LJ, et al. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension 2001;38:821-6.
Rodriguez-Moran M, Guerrero-Romero F, Lazcano-Burciaga G. Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes. J Diabetes Complications 1998;12:273-8.
- Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9.
- Strommen GL, Dorworth TE, Walker PR, et al. Treatment of suspected postcholecystectomy diarrhea with psyllium hydrophilic mucilloid. Clin Pharm 1990;9:206-8.
- Marteau P, Flourie B, Cherbut C, et al. Digestibility and bulking effect of ispaghula husks in healthy humans. Gut 1994;35:1747-52.
- Anderson JW, Zettwoch N, Feldman T, et al. Cholesterol-lowering effects of psyllium hydrophilic mucilloid for hypercholesterolemic men. Arch Intern Med 1988;148:292-6.
- Roe DA, Kalkwarf H, Stevens J. Effect of fiber supplements on the apparent absorption of pharmacological doses of riboflavin. J Am Diet Assoc 1988;88:211-3.
- Ashraf W, Pfeiffer RF, Park F, et al. Constipation in Parkinson's disease: objective assessment and response to psyllium. Mov Disord 1997;12:946-51.
- Frati Munari AC, Benitez Pinto W, Raul Ariza Andraca C, Casarrubias M. Lowering glycemic index of food by acarbose and Plantago psyllium mucilage. Arch Med Res 1998;29:137-41.
- Ejderhamn J, Hedenborg G, Strandvik B. Long-term double-blind study on the influence of dietary fibres on faecal bile acid excretion in juvenile ulcerative colitis. Scand J Clin Lab Invest 1992;52:697-706.
- Rossander L. Effect of dietary fiber on iron absorption in man. Scand J Gastroenterol Suppl 1987;129:68-72.
- McRorie JW, Daggy BP, Morel JG, et al. Psyllium is superior to docusate sodium for treatment of chronic constipation. Aliment Pharmacol Ther 1998;12:491-7.
- Hallert C, Kaldma M, Petersson BG. Ispaghula husk may relieve gastrointestinal symptoms in ulcerative colitis in remission. Scand J Gastroenterol 1991;26:747-50.
- Daggy BP, O'Connell NC, Jerdack GR, et al. Additive hypocholesterolemic effect of psyllium and cholestyramine in the hamster: influence on fecal sterol and bile acid profiles. J Lipid Res 1997;38:491-502.
- Everson GT, Daggy BP, McKinley C, Story JA. Effects of psyllium hydrophilic mucilloid on LDL-cholesterol and bile acid synthesis in hypercholesterolemic men. J Lipid Res 1992;33:1183-92.
- Maciejko JJ, Brazg R, Shah A, et al. Psyllium for the reduction of cholestyramine-associated gastrointestinal symptoms in the treatment of primary hypercholesterolemia. Arch Fam Med 1994;3:955-60.
- Cheskin LJ, Kamal N, Crowell MD, et al. Mechanisms of constipation in older persons and effects of fiber compared with placebo. J Am Geriatr Soc 1995;43:666-9.
- Belknap D, Davidson LJ, Smith CR. The effects of psyllium hydrophilic mucilloid on diarrhea in enterally fed patients. Heart Lung 1997;26:229-37.
- Alabaster O, Tang Z, Shivapurkar N. Dietary fiber and the chemopreventive modelation of colon carcinogenesis. Mutation Res 1996;350:185-97.
- Jarjis HA, Blackburn NA, Redfern JS, Read NW. The effect of ispaghula (Fybogel and Metamucil) and guar gum on glucose tolerance in man. Br J Nutr 1984;51:371-8.
- Little P, Trafford L. Dietary fibre and renal failure: comparison of sterculia and ispaghula. Clin Nephrol 1991;36:309.
- Schaller DR. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1073.
- Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3.
- Arlian LG, Vyszenski-Moher DL, Lawrence AT, et al. Antigenic and allergenic analysis of psyllium seed components. J Allergy Clin Immunol 1992;89:866-76.
- James JM, Cooke SK, Barnett A, Sampson HA. Anaphylactic reactions to a psyllium-containing cereal. J Allergy Clin Immunol 1991;88:402-8.
- Wolever TM, Jenkins DJ, Mueller S, et al. Psyllium reduces blood lipids in men and women with hyperlipidemia. Am J Med Sci 1994;307:269-73.
- Spence JD, Huff MW, Heidenheim P, et al. Combination therapy with colestipol and psyllium mucilloid in patients with hyperlipidemia. Ann Intern Med 1995;123:493-9.
- Jensen CD, Haskell W, Whittam JH. Long-term effects of water-soluble dietary fiber in the management of hypercholesterolemia in healthy men and women. Am J Cardiol 1997;79:34-7.
- Jenkins DJ, Kendall CW, Vuksan V. Viscous fibers, health claims, and strategies to reduce cardiovascular disease risk. Am J Clin Nutr 2000;71:401-2.
- Bobrove AM. Misoprostol, diarrhea, and psyllium mucilloid. Ann Intern Med 1990;112:386.
- Misra SP, Thorat VK, Sachdev GK, Anand BS. Long-term treatment of irritable bowel syndrome: results of a randomized controlled trial. Q J Med 1989:73:931-9.
- Kumar A, Kumar N, Vij JC, et al. Optimum dosage of ispaghula husk in patients with irritable bowel syndrome: correlation of symptom relief with whole gut transit time and stool weight. Gut 1987;28:150-5.
- Prior A, Whorwell PJ. Double blind study of ispaghula in irritable bowel syndrome. Gut 1987;28:1510-3.
- Longstreth GF, Fox DD, Youkeles L, et al. Psyllium therapy in the irritable bowel syndrome. A double-blind trial. Ann Intern Med 1981;95:53-6.
- Marlett JA, Li BU, Patrow CJ, Bass P. Comparative laxation of psyllium with and without senna in an ambulatory constipated population. Am J Gastroenterol 1987;82:333-7.
- Heather DJ, Howell L, Montana M, et al. Effect of a bulk-forming cathartic on diarrhea in tube-fed patients. Heart Lung 1991;20:409-13.
- Qvitzau S, Matzen P, Madsen P. Treatment of chronic diarrhoea: loperamide versus ispaghula husk and calcium. Scand J Gastroenterol 1988;23:1237-40.
- Marlett JA, Kajs TM, Fischer MH. An unfermented gel component of psyllium seed husk promotes laxation as a lubricant in humans. Am J Clin Nutr 2000;72:784-9.
- Bliss DZ, Jung HJ, Savik K, et al. Supplementation with dietary fiber improves fecal incontinence. Nurs Res 2001;50:203-13.
- Eherer AJ, Santa Ana CA, Porter J, Fordtran JS. Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein. Gastroenterology 1993;104:1007-12.
- Alabaster O, Tang ZC, Frost A, Shivapurkar N. Potential synergism between wheat bran and psyllium: enhanced inhibition of colon cancer. Cancer Lett 1993;75:53-8.
- Gerber M. Fiber and breast cancer: another piece of the puzzle--but still an incomplete picture. J Natl Cancer Inst 1996;88:857-8.
- Shulman LM, Minagar A, Weiner WJ. Perdiem causing esophageal obstruction in Parkinson's disease. Neurology 1999;52:670-1.
- Schneider RP. Perdiem causes esophageal impaction and bezoars. South Med J 1989;82:1449-50.
- Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6.
- Ho Y, Tan M, Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids. Dis Colon Rectum 2000;43:66-9.
- Williams CL, Bollella M, Spark A, Puder D. Soluble fiber enhances the hypocholesterolemic effect of the step I diet in childhood. J Am Coll Nutr 1995;14:251-7.
- Davidson MH, Dugan LD, Burns JH, et al. A psyllium-enriched cereal for the treatment of hypercholesterolemia in children: a controlled, double-blind, crossover study. Am J Clin Nutr 1996;63:96-102.
- Dennison BA, Levine DM. Randomized, double-blind, placebo-controlled, two-period crossover clinical trial of psyllium fiber in children with hypercholesterolemia. J Pediatr 1993;123:24-9.
- Kwiterovich PO. The role of fiber in the treatment of hypercholesterolemia in children and adolescents. Pediatrics 1995;96:1005-9.
- Jensen CD, Spiller GA, Gates JE, et al. The effect of acacia gum and a water-soluble dietary fiber mixture on blood lipids in humans. J Am Coll Nutr 1993;12:147-54.
- Wolever TM, ter Wal P, Spadafora P, Robb P. Guar, but not psyllium, increases breath methane and serum acetate concentrations in human subjects. Am J Clin Nutr 1992;55:719-22.
- Anderson JW, Jones AE, Riddell-Mason S. Ten different dietary fibers have significantly different effects on serum and liver lipids of cholesterol-fed rats. J Nutr 1994;124:78-83.
- Gelissen IC, Brodie B, Eastwood MA. Effect of Plantago ovata (psyllium) husk and seeds on sterol metabolism: studies in normal and ileostomy subjects. Am J Clin Nutr 194;59:395-400.
- Segawa K, Kataoka T, Fukuo Y. Cholesterol-lowering effects of psyllium seed associated with urea metabolism. Biol Pharm Bull 1998;21:184-7.
- Jenkins DJ, Wolever TM, Vidgen E, et al. Effect of psyllium in hypercholesterolemia at two monosaturated fatty acid intakes. Am J Clin Nutr 1997;65:1524-33.
- Bell LP, Hectorne K, Reynolds H, et al. Cholesterol-lowering effects of psyllium hydrophilic mucilloid. Adjunct therapy to a prudent diet for patients with mild to moderate hypercholesterolemia. JAMA 1989;261:3419-23.
- Jenkins DJ, Kendall CW, Axelsen M, et al. Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 2000;11:49-56.
- Wolever TM, Vuksan V, Eshuis H, et al. Effect of method of administration of psyllium on glycemic response and carbohydrate digestibility. J Am Coll Nutr 1991;10:364-71.
- Wolever TM, Jenkins DJ, Mueller S, et al. Method of administration influences the serum cholesterol-lowering effect of psyllium. Am J Clin Nutr 1994;59:1055-9.
- Roberts DC, Truswell AS, Bencke A, et al. The cholesterol-lowering effect of a breakfast cereal containing psyllium fibre. Med J Aust 1994;161:660-4.
- Anderson JW, Riddell-Mason S, Gustafson NJ, et al. Cholesterol-lowering effects of psyllium-enriched cereal as an adjunct to a prudent diet in the treatment of mild to moderate hypercholesterolemia. Am J Clin Nutr 1992;56:93-8.
- Pastors JG, Blaisdell PW, Balm TK, et al. Psyllium fiber reduces rise in postprandial glucose and insulin concentrations in patients with non-insulin-dependent diabetes. Am J Clin Nutr 1991;53:1431-5.
- Morgan MS, Arlian LG, Vyszenski-Moher DL, et al. English plantain and psyllium: lack of cross-allergenicity by crossed immunoelectrophoresis. Ann Allergy Asthma Immunol 1995;75:351-9.
- Bonithon-Kopp C, Kronborg O, Giacosa A, et al. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet 2000;356:1300-6.
- FDA, Ctr Food Safety, Applied Nutr. FDA allows foods containing psyllium to make health claim on reducing risk of heart disease. Available at: http://vm.cfsan.fda.gov/~lrd/tpsylliu.html
- Olson BH, Anderson SM, Becker MP, et al. Psyllium-enriched cereals lower blood total cholesterol and LDL cholesterol, but not HDL cholesterol, in hypercholesterolemic adults: results of a meta-analysis. J Nutr 1997;127:1973-80.
- Davidson MH, Maki KC, Kong JC, et al. Long-term effects of consuming foods containing psyllium seed husk on serum lipids in subjects with hypercholesterolemia. Am J Clin Nutr 1998;67:367-76.
- Anderson JW, Davidson MH, Blonde L, et al. Long-term cholesterol-lowering effects of psyllium as an adjunct to diet therapy in the treatment of hypercholesterolemia. Am J Clin Nutr 2000;71:1433-8.
- Leathwood PD, Chauffard F, Heck E, Munoz-Box R. Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacol Biochem Behav 1982;17:65-71.
- Washington N, Harris M, Mussellwhite A, Spiller RC. Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation. Am J Clin Nutr 1998;67:317-21.
- Cavaliere H, Floriano I, Medeiros-Neto G. Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid). Int J Obes Relat Metab Disord 2001;25:1095-9.
- Wolever TM, Robb PA. Effect of guar, pectin, psyllium, soy polysaccharide, and cellulose on breath hydrogen and methane in healthy subjects. Am J Gastroenterol 1992:87:305-10.
- Schwesinger WH, Kurtin WE, Page CP, et al. Soluble dietary fiber protects against cholesterol gallstone formation. Am J Surg 1999;177:307-10.
- Fernandez-Banares F, Hinojosa J, Sanchez-Lombrana JL, et al. Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colits (GETECCU). Am J Gastroenterol 1999;94:427-33.
- Fernandez R, Phillips SF. Components of fiber bind iron in vitro. Am J Clin Nutr 1982;35:100-6.
- Fernandez R, Phillips SF. Components of fiber impair iron absorption in the dog. Am J Clin Nutr 1982;35:107-12.
- Freeman GL. Psyllium hypersensitivity. Ann Allergy 1994;73:490-2.
- Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8.
- Suhonen R, Kantola I, Bjorksten F. Anaphylactic shock due to ingestion of psyllium laxative. Allergy 1983;38:363-5.
- Erratum. Am J Clin Nutr 1998;67:1286.
- Schectman G, Hiatt J, Hartz A. Evaluation of the effectiveness of lipid-lowering therapy (bile acid sepquestrants, niacin, psyllium and lovastatin) for treating hypercholesterolemia in veterans. Am J Cardiol 1993;71:759-65.
- Sprecher DL, Harris BV, Goldberg AC. Efficacy of psyllium in reducing serum cholesterol levels in hypercholesterolemic patients on high- or low-fat diets. Ann Intern Med 1993;119:545-54.
- Chan EK, Schroeder DJ. Psyllium in hypercholesterolemia. Ann Pharmacother 1995;29:625-7.
- Jalihal A, Kurian G. Ispaghula therapy in irritable bowel syndrome: improvement in overall well-being is related to reduction bowel dissatisfaction. J Gastroenterol Hepatol 1990;5:507-13.
- Stoy DB, LaRosa JC, Brewer BK, et al. Cholesterol-lowering effects of ready-to-eat cereal containing psyllium. J Am Diet Assoc 1993;93:910-2.
- Anderson JW, Allgood LD, Turner J, et al. Effects of psyllium on glucose and serum lipid responses in men with type 2 diabetes and hypercholesterolemia. Am J Clin Nutr 1999;70:466-73.
- Anderson JW, Allgood LD, Lawrence A, et al. Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 2000;71:472-9.
- Agha FP, Nostrant TT, Fiddian-Green RG. Giant colonic bezoar: a medication bezoar due to psyllium seed husks. Am J Gastroenterol 1984;79:319-21.
- Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
- Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
- Cook IJ, Irvine EJ, Campbell D, et al. Effect of dietary fiber on rectosigmoid motility in patients with irritable bowel syndrome: A controlled, crossover study. Gastroenterology 1990;98:66-72.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Show more references
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