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What is it?

Melatonin is a hormone found naturally in the body. Melatonin used as medicine is usually made synthetically in a laboratory. It is most commonly available in pill form, but melatonin is also available in forms that can be placed in the cheek or under the tongue. This allows the melatonin to be absorbed directly into the body.

People use melatonin to adjust the body’s internal clock. It is used for jet lag, for adjusting sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and for helping blind people establish a day and night cycle.

Melatonin is also used for the inability to fall asleep (insomnia); delayed sleep phase syndrome (DSPS); insomnia associated with attention deficit-hyperactivity disorder (ADHD); insomnia due to certain high blood pressure medications called beta-blockers; and sleep problems in children with developmental disorders including autism, cerebral palsy, and intellectual disabilities. It is also used as a sleep aid after discontinuing the use of benzodiazepine drugs and to reduce the side effects of stopping smoking.

Some people use melatonin for Alzheimer’s disease, ringing in the ears, depression, chronic fatigue syndrome (CFS), fibromyalgia, migraine and other headaches, irritable bowel syndrome (IBS), bone loss (osteoporosis), a movement disorder called tardive dyskinesia (TD), epilepsy, as an anti-aging agent, for menopause, and for birth control.

Other uses include breast cancer, brain cancer, lung cancer, prostate cancer, head cancer, neck cancer, and gastrointestinal cancer. Melatonin is also used for some of the side effects of cancer treatment (chemotherapy) including weight loss, nerve pain, weakness, and a lowered number of clot-forming cells (thrombocytopenia).

It is also used to calm people before they are given anesthesia for surgery.

The forms of melatonin that can be absorbed through the cheek or under the tongue are used for insomnia, shift-work disorder, and to calm people before receiving anesthesia for surgery.

Sometimes people apply melatonin to the skin to protect against sunburn.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for MELATONIN are as follows:

Likely effective for...

  • Sleeping problems in children with autism and intellectual disabilities. Taking melatonin by mouth is helpful for disturbed sleep-wake cycles in children and adolescents with intellectual disabilities, autism, and other central nervous system disorders. Melatonin also appears to shorten the time it takes for to children with developmental disabilities (cerebral palsy, autism, and intellectual disabilities.
  • Sleep disorders in blind people.

Possibly effective for...

  • Jet lag. Most research shows that melatonin can improve certain symptoms of jet lag such as alertness and movement coordination. Melatonin also seems to improve, to a lesser extent, other jet lag symptoms such as daytime sleepiness and tiredness. But, melatonin might not be effective for shortening the time it takes for people with jet lag to fall asleep.
  • Insomnia. For primary insomnia (insomnia that is not attributable to a medical or environmental cause), melatonin seems to be able to shorten the amount of time it takes to fall asleep, but only by about 12 minutes, according to one research study. Melatonin does not appear to significantly improve “sleep efficiency,” the percentage of time that a person actually spends sleeping during the time set aside for sleeping. Some people say melatonin makes them sleep better, even though tests don’t agree. There is some evidence that melatonin is more likely to help older people than younger people or children. This may be because older people have less melatonin in their bodies to start with.
    There is some interest in finding out whether melatonin might help with “secondary insomnia.” This is trouble sleeping that is related to other conditions such as Alzheimer’s disease; depression; schizophrenia; hospitalization; and “ICU syndrome,” sleep disturbances in the intensive care unit. Research to date suggests that melatonin might not help to reduce the time it takes to fall asleep in secondary insomnia, but it might improve sleep efficiency.
  • Cluster headaches. Taking 10 mg of melatonin by mouth every evening might reduce the number of cluster headaches. However, taking 2 mg of melatonin at bedtime doesn’t seem to work.
  • Reducing anxiety before surgery. Melatonin used under the tongue seems to be as effective in reducing anxiety before surgery as midazolam, a conventional medication. It also seems to have fewer side effects in some people.
  • Helping elderly people sleep after they stop taking a type of drug called benzodiazepines. The controlled-release form of melatonin is the type that was shown to work for this.
  • Helping decrease symptoms in people who are quitting smoking. A single oral dose of 0.3 mg of melatonin taken 3.5 hours after stopping cigarettes seems to reduce anxiety, restlessness, irritability, depression, and cigarette craving over the next 10 hours.
  • Low blood platelets (thrombocytopenia).
  • Improving the effectiveness of certain cancer medications used to fight tumors in the breast, lung, kidney, liver, pancreas, stomach, colon, prostate, and decreasing some side effects of cancer treatment.
  • Decreasing symptoms of a movement disorder called tardive dyskinesia (TD).
  • Decreasing sunburn when applied to the skin in a cream form before going into the sun.

Possibly ineffective for...

  • Adjusting sleep schedule in people that do shift work.

Likely ineffective for...

  • Depression. There is also some concern that melatonin might worsen symptoms in some people.

Insufficient evidence to rate effectiveness for...

  • Epilepsy. There is some evidence that melatonin at bedtime may reduce the number and length of seizures in children with epilepsy. But melatonin should be used cautiously, because melatonin may increase the number of seizures in some people.
  • Menopausal symptoms. Limited research suggests that melatonin does not relieve menopausal symptoms. However, melatonin in combination with soy isoflavones might help psychological symptoms associated with menopause.
  • Sleep problems associated with attention deficit-hyperactivity disorder (ADHD). Limited research suggests melatonin might improve insomnia in children with ADHD who are taking stimulants. But improved sleep does not seem to decrease symptoms of ADHD.
  • Migraine headache. There is some evidence that taking melatonin nightly before bed can prevent episodic migraine headache. When headaches do occur, they are milder and pass more quickly. Some research suggests that melatonin production might be altered in people with migraine.
  • Insomnia caused by medications used for high blood pressure (beta-blockers).
  • Headache characterized by sudden sharp pain (idiopathic stabbing headache).
  • Ringing in the ears (tinnitus).
  • Chronic fatigue syndrome (CFS).
  • Osteoporosis.
  • Irritable bowel syndrome (IBS).
  • Birth control.
  • Fibromyalgia.
  • Aging.
  • Other conditions.
More evidence is needed to rate melatonin for these uses.

How does it work?

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Melatonin’s main job in the body is to regulate night and day cycles or sleep-wake cycles. Darkness causes the body to produce more melatonin, which signals the body to prepare for sleep. Light decreases melatonin production and signals the body to prepare for being awake. Some people who have trouble sleeping have low levels of melatonin. It is thought that adding melatonin from supplements might help them sleep.

Are there safety concerns?

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Melatonin is LIKELY SAFE for most adults when taken by mouth short-term or applied to the skin. It can cause some side effects including headache, short-term feelings of depression, daytime sleepiness, dizziness, stomach cramps, and irritability. Do not drive or use machinery for four to five hours after taking melatonin.

Special precautions & warnings:

Pregnancy and breast-feeding: Melatonin is POSSIBLY UNSAFE in pregnancy. Don’t use it. Melatonin might also interfere with ovulation, making it more difficult to become pregnant.

Not enough is known about the safety of using melatonin when breast-feeding. It’s best not to use it.

Children: Melatonin should not be used in most children. It is POSSIBLY UNSAFE. Because of its effects on other hormones, melatonin might interfere with development during adolescence.

High blood pressure: Melatonin can raise blood pressure in people who are taking certain medications to control blood pressure. Avoid using it.

Diabetes: Melatonin might increase blood sugar in people with diabetes. Monitor your blood sugar carefully, if you have diabetes and take melatonin.

Depression: Melatonin can make symptoms of depression worse.

Seizure disorders: Using melatonin might increase the risk of having a seizure.

Are there interactions with medications?

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Be cautious with this combination.

Birth control pills (Contraceptive drugs)
The body makes melatonin. Birth control pills seem to increase how much melatonin the body makes. Taking melatonin along with birth control pills might cause too much melatonin to be in the body.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.

Caffeine might decrease melatonin levels in the body. Taking melatonin along with caffeine might decrease the effectiveness of melatonin supplements.

Fluvoxamine (Luvox)
Taking fluvoxamine (Luvox) can increase the amount of melatonin that the body absorbs. Taking melatonin along with fluvoxamine (Luvox) might increase the effects and side effects of melatonin.

Medications for diabetes (Antidiabetes drugs)
There is some concern that melatonin might increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. By affecting blood sugar, melatonin might decrease or increase the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Medications that decrease the immune system (Immunosuppressants)
Melatonin might increase the immune system. Taking melatonin along with medications that decrease the immune system might decrease the effectiveness of medications that decrease the immune system.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Melatonin might slow blood clotting. Taking melatonin along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Nifedipine GITS (Procardia XL)
Nifedipine GITS (Procardia XL) is used to lower blood pressure. Taking melatonin might decrease the effectiveness of nifedipine GITS for lowering blood pressure.

Sedative medications (Benzodiazepines)
Melatonin might cause sleepiness and drowsiness. Drugs that cause sleepiness and drowsiness are called sedatives. Taking melatonin along with sedative medications might cause too much sleepiness.

Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.

Sedative medications (CNS depressants)
Melatonin might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking melatonin along with sedative medications might cause too much sleepiness.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Verapamil (Calan, Covera, Isoptin, Verelan)
The body breaks down melatonin to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can increase how quickly the body gets rid of melatonin. Taking melatonin along with verapamil (Calan, Covera, Isoptin, Verelan) might decrease the effectiveness of melatonin.


Be watchful with this combination.

Flumazenil (Romazicon)
Flumazenil (Romazicon) might decrease the effects of melatonin. It is not yet clear why this interaction occurs. Taking flumazenil (Romazicon) along with melatonin might decrease the effectiveness of melatonin supplements.

Are there interactions with herbs and supplements?

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Herbs and supplements that might slow blood clotting
Melatonin might increase the effect of herbs that slow blood clotting and might increase the risk of bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, willow, and others.

Herbs and supplements with sleep-promoting (sedative) properties
Using melatonin along with herbs that have sedative properties might increase the effects and side effects of melatonin. Some of these supplements include 5-HTP, calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, skullcap, valerian, yerba mansa, and others.

Are there interactions with foods?

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There are no known interactions with foods.

What dose is used?

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The following doses have been studied in scientific research:

  • For insomnia:
    • 0.3-5 mg at bedtime is a typical dose.
    • In children with insomnia due to delayed sleep onset, melatonin 5 mg at 6:00 PM daily.
    • In children with developmental disorders (including cerebral palsy, autism, and intellectual disabilities), melatonin 5 mg at 8:00 PM daily. Both immediate-release and sustained-release preparations have been used.
  • For jet lag: 0.5-5 mg at bedtime is commonly taken on the arrival day at the destination, continuing for 2-5 days. Low doses of 0.5-3 mg are often used to avoid the hypnotic properties of the higher 4-5 mg doses.
  • For tardive dyskinesia (TD): 10 mg daily of a controlled-release formulation.
  • As treatment for solid tumors in combination with conventional therapy: 10-50 mg along with radiotherapy, chemotherapy, or interleukin 2 (IL-2). Melatonin is typically started 7 days before the start of chemotherapy and continued throughout full treatment course.
  • For treatment of prostate cancer that has spread to other sites (metastatic cancer) and is resistant to triptorelin used alone: 20 mg taken daily has been used in combination with 3.75 mg of triptorelin injected into the muscle every 28 days.
  • For prevention and treatment of lowered clot-forming cells (thrombocytopenia) associated with cancer chemotherapy: 20 mg each evening.
  • For benzodiazepine withdrawal in elderly people with insomnia: 2 mg of controlled-release melatonin taken at bedtime for 6 weeks (the benzodiazepine dosage is reduced 50% during the second week, 75% during weeks 3 and 4, and stopped during weeks 5 and 6) and continued up to 6 months.
  • For prevention of cluster headache: an evening dose of 10 mg.
  • For reducing anxiety before surgery in adults: 0.05 mg/kg under the tongue.
  • For reducing nicotine withdrawal symptoms: 0.3 mg orally 3.5 hours after stopping smoking.

Other names

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5-Methoxy-N-Acetyltryptamine, MEL, Melatonina, Mélatonine, MLT, N-acetyl-5-methoxytryptamine, N-Acétyl-5-Méthoxytryptamine, Pineal Hormone.


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To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (


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To see all references for the Melatonin page, please go to

  1. Ionescu D, Badescu C Ilie A Acalovschi I. Melatonin as premedication for laparoscopic cholecystectomy: A double- blind, placebo-controlled study: Scientific letter. SAJAA 2008;57:8-11.
  2. Cardinali DP, Brusco LI, and Liberczuk C. The use of melatonin in Alzheimer's disease. Neuroendocrinol Lett 2002;23(Suppl 1):20-23.
  3. Singer CM, Moffit MT, Colling ED, and et al. Low dose melatonin administration and nocturnal activity levels in patients with Alzheimer's disease [abstract]. Sleep Res 1997;26:752.
  4. Yan J, Shen F Wang K Wu M. Co-antitumor effect and hepatic protection of melatonin on advanced primary liver cancer treated by transcatheter arterial chemoembolization. Acad J Sec Mil Med Univ 2001;22:858-886.
  5. Brusco LI, Marquez M, and Cardinali DP. Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease. Neuroendocrinol Lett 1998;19:111-115.
  6. Espezel H, Jan JE, O'Donnell ME, and et al. The use of melatonin to treat sleep-wake-rhythm disorders in children who are visually impaired. J Vis Impair Blind 1996;90:34-50.
  7. Ackerstedt T, Gillberg M. Subjective and objective sleepiness in the active individual. Int J Neurosci 1990;52:29-37.
  8. Ritvo ER, Ritvo R Yuwiler A Brothers A Freeman BJ Plotkin S. Elevated daytime melatonin concentrations in autism: a pilot study. Eur Child Adolesc Psychiatry 1993;2:75-78.
  9. Nickelsen T, Lang A, and Bergau L. The effect of 6-, 9- and 11-hour time shifts on circadian rhythms: adaptation of sleep parameters and hormonal patterns following the intake of melatonin or placebo. In: Arendt J and Pevet P. Advances in Pineal Research. London: John Libbey;1991.
  10. Arendt J, Aldhous M, English J, and et al. Some effects of jet-lag and their alleviation by melatonin. Ergonomics 1987;30:1379-1393.
  1. Waldhauser F, Waldhauser M Lieberman HR Deng M Lynch HJ Wurtman RJ. Bioavailability of oral melatonin in humans. Neuroendocrinology 1984;39:307-313.
  2. Serfaty MA, Osborne D Buszewicz M J. et al. The Effect of Exogeneous Melatonin in Major Depression. Chronobiol Int. 2003;20:1191-1192.
  3. Zisapel N, Tarash R Laudon M. Effects of fast- and controlled-release melatonin formulations on daytime sleep and mood. 7th Colloquium 1996;1.
  4. Terlo L, Laudon M Tarasch R. et al. Effects of low doses of melatonin on late afternoon napping and mood. Biol Rhythm Res. 1997;28:2-15.
  5. Laurant M, Nagtegaal JE Smits MG Kerkhof GA Coenen AML. Influence of melatonin on vigilance and cognitive functions in delayed sleep phase syndrome. Int Chronobiol 1997;8:79-82.
  6. Dagan, Y., Zisapel, N., Nof, D., Laudon, M., and Atsmon, J. Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report. Eur Neuropsychopharmacol. 1997;7:157-160.
  7. Pieri C, Moroni M, Marcheselli F, and et al. Melatonin is an efficient antioxidant. Arch Gerontol Geriatr 1995;20:159-165.
  8. Reiter RJ, Tan DX, Acuña-Castroviejo D, and et al. Melatonin: mechanisms and actions as an antioxidant. Curr Top Biophys 2000;24:171-183.
  9. Blask DE, Hill SM, Pelletier DB, and et al. Melatonin: an anticancer hormone of the pineal gland. In: Reiter RJ and Pang SF. Advances in Pineal Research. London, England: John Libbey;1989.
  10. Birdsall TC. The biological effects and clinical uses of the pineal hormone melatonin. Altern Med Rev 1996;1:94-102.
  11. Reiter RJ, Poeggeler B, Tan D, and et al. Antioxidant capacity of melatonin: a novel action not requiring a receptor. Neuroendocrinol.Lett. 1993;15(1+2):103-116.
  12. Reiter RJ, Tan DX, and Manchester LC. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: a review of the evidence. Cell Biochem Biophys 2001;34:237-256.
  13. Fischer, T. W., Scholz, G., Knoll, B., Hipler, U. C., and Elsner, P. Melatonin reduces UV-induced reactive oxygen species in a dose- dependent manner in IL-3-stimulated leukocytes. J Pineal Res 2001;31:39-45.
  14. Singer C, Wild K, Sack R, and et al. High dose melatonin is well tolerated by the elderly [abstract]. Sleep Research 1994;23:86.
  15. Nikolakopoulou, D. and Stamatakis A. The Role of Melatonin in the Pathology of the Cardiovascular System. Nosileftiki 2009;48:143-149.
  16. Lissoni P, Ardizzoia A, Barni S, and et al. A randomized study of tamoxifen alone versus tamoxifen plus melatonin in estrogen receptor-negative heavily pretreated metastatic breast cancer patients. Oncology Reports 1995;2:871-873.
  17. Birau N, Peterssen U, Meyer C, and et al. Hypotensive effect of melatonin in essential hypertension. IRCS Med Sci 1981;9:905-906.
  18. Sanchez-Forte H, Moreno-Madrid, F., Munoz-Hoyos A, and et al. Efecto de la melatonina como anticonvulsivante y protector neuronal. Revista de Neurologia 1997;25:1229-1234.
  19. Jean-Louis G, Zizi F, Von Gizycki H, and et al. Acute effects of melatonin therapy on behavior, mood, and cognition [abstract]. Sleep Res 1997;26:108.
  20. Yegin, Z. Mutluay R. Elbeg S. Karakus R. and Cakir N. The Impact of Melatonin on Glucose Homeostasis. Turkish Journal of Endocrinology and Metabolism 2009;13:52-55.
  21. Spitzer RL, Terman M, Malt U, and et al. Failure of melatonin to affect jet lag in a randomized double blind trial. Abstracts of the Annual Meeting of the Society for Light Treatment and Biological Rhythms 1997;9:1.
  22. Arendt J and Aldhous M. Further evaluation of the treatment of jet-lag by melatonin: a double-blind crossover study. Annu Rev Chronopharmacol 1988;5:53-55.
  23. Garfinkel D, Laudon M, and Zisapel N. Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs. Arch Gerontol Geriat 1997;24:223-231.
  24. Cardinali DP, Gvozdenovich E, and Kaplan MR. A double blind-placebo controlled study on melatonin efficacy to reduce anxiolytic benzodiazepine use in the elderly. Neuroendocrinol.Lett 2002;23:55-60.
  25. Lissoni P, Barni S, Ardizzoia A, and et al. Immunotherapy with low-dose interleukin-2 in association with melatonin as salvage therapy for metastatic soft tissue sarcomas. Oncology Reports 1997;4:157-159.
  26. Brivio F, Lissoni P, Fumagalli L, and et al. Preoperative neuroimmunotherapy with subcutaneous low-dose interleukin-2 and melatonin in patients with gastrointestinal tumors: its efficacy in preventing surgery-induced lymphocytopenia. Oncology Reports 1995;2:597-599.
  27. Petterborg LJ, Thalen BE, Kjellman BF, and et al. Effect of melatonin replacement on serum hormone rhythms in a patient lacking endogenous melatonin. Brain Res Bull 1991;27:181-185.
  28. Siddiqui MA, Nazmi AS, Karim S, and et al. Effect of melatonin and valproate in epilepsy and depression. Indian J Pharmacol 2001;33:378-381.
  29. Brueske V, Allen J, Kepic T, and et al. Melatonin inhibition of seizure activity in man [abstract]. Electroencephalog Clin Neurophysiol 1981;51:20P.
  30. Suhner A, Schlagenhauf P, Hoefer I, and et al. Efficacy and tolerability of melatonin and zolpidem for the alleviation of jet-lag. 6th Conference of the International Society of Travel Medicine, Montreal, Canada.1999.
  31. Barni S, Lissoni P, Paolorossi F, and et al. Prevention of chemotherapy-induced thrombocytopenia by the pineal hormone melatonin (MLT) [abstract]. Proc Annu Meet Am Soc Clin Oncol 1996;15:528.
  32. U.S.Food and Drug Administration. Special Nutritionals Adverse Events Monitoring System: registered case reports.
  33. Hahm, H., Kujawa, J., and Augsburger, L. Comparison of melatonin products against USP's nutritional supplements standards and other criteria. J Am Pharm Assoc (Wash.) 1999;39:27-31. View abstract.
  34. Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., and Matsumoto, A. M. Daily melatonin administration at middle age suppresses male rat visceral fat, plasma leptin, and plasma insulin to youthful levels. Endocrinology 1999;140:1009-1012. View abstract.
  35. Italian Study Group for the Di Bella Multitherapy Trials. Evaluation of an unconventional cancer treatment (the Di Bella multitherapy): results of phase II trials in Italy. Italian Study Group for the Di Bella Multitherapy Trails. BMJ 1-23-1999;318:224-228. View abstract.
  36. Gilbert, S. S., van den Heuvel, C. J., and Dawson, D. Daytime melatonin and temazepam in young adult humans: equivalent effects on sleep latency and body temperatures. J Physiol 2-1-1999;514 ( Pt 3):905-914. View abstract.
  37. Dawson, D., Rogers, N. L., van den Heuvel, C. J., Kennaway, D. J., and Lushington, K. Effect of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs. J Biol Rhythms 1998;13:532-538. View abstract.
  38. Cajochen, C., Krauchi, K., Danilenko, K. V., and Wirz-Justice, A. Evening administration of melatonin and bright light: interactions on the EEG during sleep and wakefulness. J.Sleep Res. 1998;7:145-157. View abstract.
  39. Pillar, G., Etzioni, A., Shahar, E., and Lavie, P. Melatonin treatment in an institutionalised child with psychomotor retardation and an irregular sleep-wake pattern. Arch Dis Child 1998;79:63-64. View abstract.
  40. Jean-Louis, G., von Gizycki, H., and Zizi, F. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res 1998;25:177-183. View abstract.
  41. Morishima, I., Matsui, H., Mukawa, H., Hayashi, K., Toki, Y., Okumura, K., Ito, T., and Hayakawa, T. Melatonin, a pineal hormone with antioxidant property, protects against adriamycin cardiomyopathy in rats. Life Sci 1998;63:511-521. View abstract.
  42. Rogers, N. L., Phan, O., Kennaway, D. J., and Dawson, D. Effect of daytime oral melatonin administration on neurobehavioral performance in humans. J Pineal Res 1998;25:47-53. View abstract.
  43. Mayo, J. C., Sainz, R. M., Uria, H., Antolin, I., Esteban, M. M., and Rodriguez. Inhibition of cell proliferation: a mechanism likely to mediate the prevention of neuronal cell death by melatonin. J Pineal Res 1998;25:12-18. View abstract.
  44. Nagtegaal, J. E., Kerkhof, G. A., Smits, M. G., Swart, A. C., and Van Der Meer, Y. G. Delayed sleep phase syndrome: A placebo-controlled cross-over study on the effects of melatonin administered five hours before the individual dim light melatonin onset. J Sleep Res 1998;7:135-143. View abstract.
  45. Siebler, M., Steinmetz, H., and Freund, H. J. Therapeutic entrainment of circadian rhythm disorder by melatonin in a non-blind patient. J Neurol 1998;245(6-7):327-328. View abstract.
  46. Coiro, V., Volpi, R., Capretti, L., Giuliani, N., Caffarri, G., Colla, R., Marchesi, C., and Chiodera, P. Different effects of naloxone on the growth hormone response to melatonin and pyridostigmine in normal men. Metabolism 1998;47:814-816. View abstract.
  47. Chiodera, P., Volpi, R., Capretti, L., Giuliani, N., Caffarri, G., and Coiro, V. Melatonin inhibits oxytocin response to insulin-induced hypoglycemia, but not to angiotensin II in normal men. J Neural Transm. 1998;105(2-3):173-180. View abstract.
  48. Manev, H. and Uz, T. Oral melatonin in neurologically disabled children. Lancet 6-27-1998;351:1963. View abstract.
  49. Chiodera, P., Volpi, R., Capretti, L., Giuliani, N., Maffei, M. L., and Coiro, V. Effect of melatonin on arginine vasopressin secretion stimulated by physical exercise or angiotensin II in normal men. Neuropeptides 1998;32:125-129. View abstract.
  50. Hatonen, T., Laakso, M. L., Heiskala, H., Alila-Johansson, A., Sainio, K., and Santavuori, P. Bright light suppresses melatonin in blind patients with neuronal ceroid-lipofuscinoses. Neurology 1998;50:1445-1450. View abstract.
  51. Dagan, Y., Yovel, I., Hallis, D., Eisenstein, M., and Raichik, I. Evaluating the role of melatonin in the long-term treatment of delayed sleep phase syndrome (DSPS). Chronobiol.Int 1998;15:181-190. View abstract.
  52. Shochat, T., Haimov, I., and Lavie, P. Melatonin--the key to the gate of sleep. Ann.Med 1998;30:109-114. View abstract.
  53. Kripke, D. F., Elliot, J. A., Youngstedt, S. D., and Smith, J. S. Melatonin: marvel or marker? Ann.Med 1998;30:81-87. View abstract.
  54. Youngstedt, S. D., Kripke, D. F., and Elliott, J. A. Melatonin excretion is not related to sleep in the elderly. J Pineal Res 1998;24:142-145. View abstract.
  55. Kostoglou-Athanassiou, I., Treacher, D. F., Wheeler, M. J., and Forsling, M. L. Melatonin administration and pituitary hormone secretion. Clin Endocrinol (Oxf) 1998;48:31-37. View abstract.
  56. Lissoni, P., Fumagalli, L., Paolorossi, F., Rovelli, F., Roselli, M. G., and Maestroni, G. J. Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5- methoxytryptophol in association with low-dose IL-2 and melatonin. J Biol Regul.Homeost.Agents 1997;11:119-122. View abstract.
  57. Cagnacci, A., Arangino, S., Angiolucci, M., Maschio, E., and Melis, G. B. Influences of melatonin administration on the circulation of women. Am J Physiol 1998;274(2 Pt 2):R335-R338. View abstract.
  58. Hughes, R. J., Sack, R. L., and Lewy, A. J. The role of melatonin and circadian phase in age-related sleep- maintenance insomnia: assessment in a clinical trial of melatonin replacement. Sleep 1998;21:52-68. View abstract.
  59. Grin, W. and Grunberger, W. A significant correlation between melatonin deficiency and endometrial cancer. Gynecol Obstet Invest 1998;45:62-65. View abstract.
  60. Sack, R. L., Hughes, R. J., Edgar, D. M., and Lewy, A. J. Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms? Sleep 1997;20:908-915. View abstract.
  61. Zhdanova, I. V., Lynch, H. J., and Wurtman, R. J. Melatonin: a sleep-promoting hormone. Sleep 1997;20:899-907. View abstract.
  62. Hong, Y. G. and Riegler, J. L. Is melatonin associated with the development of autoimmune hepatitis? J Clin Gastroenterol 1997;25:376-378. View abstract.
  63. Guardiola-Lemaitre, B. Toxicology of melatonin. J Biol Rhythms 1997;12:697-706. View abstract.
  64. Arendt, J. Safety of melatonin in long-term use (?). J Biol Rhythms 1997;12:673-681. View abstract.
  65. Sack, R. L. and Lewy, A. J. Melatonin as a chronobiotic: treatment of circadian desynchrony in night workers and the blind. J Biol Rhythms 1997;12:595-603. View abstract.
  66. Lewy, A. J. and Sack, R. L. Exogenous melatonin's phase-shifting effects on the endogenous melatonin profile in sighted humans: a brief review and critique of the literature. J Biol Rhythms 1997;12:588-594. View abstract.
  67. Constantinescu, C. S., Hilliard, B., Ventura, E., and Rostami, A. Luzindole, a melatonin receptor antagonist, suppresses experimental autoimmune encephalomyelitis. Pathobiology 1997;65:190-194. View abstract.
  68. Kunz, D. and Bes, F. Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. Neuropsychobiology 1997;36:211-214. View abstract.
  69. Force, R. W., Hansen, L., and Bedell, M. Psychotic episode after melatonin. Ann Pharmacother. 1997;31:1408. View abstract.
  70. Dauchy, R. T., Sauer, L. A., Blask, D. E., and Vaughan, G. M. Light contamination during the dark phase in "photoperiodically controlled" animal rooms: effect on tumor growth and metabolism in rats. Lab Anim Sci 1997;47:511-518. View abstract.
  71. Mishima, K., Satoh, K., Shimizu, T., and Hishikawa, Y. Hypnotic and hypothermic action of daytime-administered melatonin. Psychopharmacology (Berl) 1997;133:168-171. View abstract.
  72. Chase, J. E. and Gidal, B. E. Melatonin: therapeutic use in sleep disorders. Ann Pharmacother 1997;31:1218-1226. View abstract.
  73. Steindl, P. E., Ferenci, P., and Marktl, W. Impaired hepatic catabolism of melatonin in cirrhosis. Ann Intern Med 9-15-1997;127:494. View abstract.
  74. Esquifino, A., Agrasal, C., Velazquez, E., Villanua, M. A., and Cardinali, D. P. Effect of melatonin on serum cholesterol and phospholipid levels, and on prolactin, thyroid-stimulating hormone and thyroid hormone levels, in hyperprolactinemic rats. Life Sci 1997;61:1051-1058. View abstract.
  75. Horrigan, J. P. and Barnhill, L. J. More on melatonin. J Am Acad Child Adolesc.Psychiatry 1997;36:1014. View abstract.
  76. Slotten, H. A. and Krekling, S. Does melatonin have an effect on cognitive performance? Psychoneuroendocrinology 1996;21:673-680. View abstract.
  77. Tanaka, H., Araki, A., Ito, J., Tasaki, T., Miyamoto, A., and Cho, K. Improvement of hypertonus after treatment for sleep disturbances in three patients with severe brain damage. Brain Dev. 1997;19:240-244. View abstract.
  78. Robertson, J. M. and Tanguay, P. E. Case study: the use of melatonin in a boy with refractory bipolar disorder. J Am Acad Child Adolesc Psychiatry 1997;36:822-825. View abstract.
  79. Hughes, R. J. and Badia, P. Sleep-promoting and hypothermic effects of daytime melatonin administration in humans. Sleep 1997;20:124-131. View abstract.
  80. Cajochen, C., Krauchi, K., Mori, D., Graw, P., and Wirz-Justice, A. Melatonin and S-20098 increase REM sleep and wake-up propensity without modifying NREM sleep homeostasis. Am.J.Physiol 1997;272(4 Pt 2):R1189-R1196. View abstract.
  81. Krauchi, K., Cajochen, C., Mori, D., Graw, P., and Wirz-Justice, A. Early evening melatonin and S-20098 advance circadian phase and nocturnal regulation of core body temperature. Am J Physiol 1997;272(4 Pt 2):R1178-R1188. View abstract.
  82. Bojanowska, E. and Forsling, M. L. The effects of melatonin on vasopressin secretion in vivo: interactions with acetylcholine and prostaglandins. Brain Res Bull 1997;42:457-461. View abstract.
  83. Lissoni, P., Barni, S., Brivio, F., Rossini, F., Fumagalli, L., and Tancini, G. Treatment of cancer-related thrombocytopenia by low-dose subcutaneous interleukin-2 plus the pineal hormone melatonin: a biological phase II study. J Biol Regul.Homeost.Agents 1995;9:52-54. View abstract.
  84. Cagnacci, A., Soldani, R., and Yen, S. S. Contemporaneous melatonin administration modifies the circadian response to nocturnal bright light stimuli. Am J Physiol 1997;272(2 Pt 2):R482-R486. View abstract.
  85. Holliman, B. J. and Chyka, P. A. Problems in assessment of acute melatonin overdose. South.Med J 1997;90:451-453. View abstract.
  86. Di, W. L., Kadva, A., Johnston, A., and Silman, R. Variable bioavailability of oral melatonin. N.Engl.J Med 4-3-1997;336:1028-1029. View abstract.
  87. deVries, M. W. and Peeters, F. P. Melatonin as a therapeutic agent in the treatment of sleep disturbance in depression. J Nerv.Ment.Dis 1997;185:201-202. View abstract.
  88. Matsumoto, M., Sack, R. L., Blood, M. L., and Lewy, A. J. The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans. J Pineal Res 1997;22:42-44. View abstract.
  89. Cagnacci, A., Arangino, S., Angiolucci, M., Maschio, E., Longu, G., and Melis, G. B. Potentially beneficial cardiovascular effects of melatonin administration in women. J Pineal Res 1997;22:16-19. View abstract.
  90. Monteleone, P., Tortorella, A., Borriello, R., Natale, M., Cassandro, P., and Maj, M. Suppression of nocturnal plasma melatonin levels by evening administration of sodium valproate in healthy humans. Biol Psychiatry 2-1-1997;41:336-341. View abstract.
  91. Hatonen, T., Alila, A., and Laakso, M. L. Exogenous melatonin fails to counteract the light-induced phase delay of human melatonin rhythm. Brain Res 2-26-1996;710(1-2):125-130. View abstract.
  92. Reid, K., Van den, Heuvel C., and Dawson, D. Day-time melatonin administration: effects on core temperature and sleep onset latency. J Sleep Res 1996;5:150-154. View abstract.
  93. McArthur, A. J., Lewy, A. J., and Sack, R. L. Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment. Sleep 1996;19:544-553. View abstract.
  94. Nave, R., Herer, P., Haimov, I., Shlitner, A., and Lavie, P. Hypnotic and hypothermic effects of melatonin on daytime sleep in humans: lack of antagonism by flumazenil. Neurosci.Lett 8-23-1996;214(2-3):123-126. View abstract.
  95. Murphy, P. J., Myers, B. L., and Badia, P. Nonsteroidal anti-inflammatory drugs alter body temperature and suppress melatonin in humans. Physiol Behav. 1996;59:133-139. View abstract.
  96. Lamberg, L. Melatonin potentially useful but safety, efficacy remain uncertain. JAMA 10-2-1996;276:1011-1014. View abstract.
  97. Lissoni, P., Vigore, L., Rescaldani, R., Rovelli, F., Brivio, F., Giani, L., Barni, S., Tancini, G., Ardizzoia, A., and Vigano, M. G. Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3: a biological phase-II study. J Biol Regul.Homeost.Agents 1995;9:155-158. View abstract.
  98. Dawson, D., Gibbon, S., and Singh, P. The hypothermic effect of melatonin on core body temperature: is more better? J Pineal Res 1996;20:192-197. View abstract.
  99. Camfield, P., Gordon, K., Dooley, J., and Camfield, C. Melatonin appears ineffective in children with intellectual deficits and fragmented sleep: six "N of 1" trials. J Child Neurol 1996;11:341-343. View abstract.
  100. Steinlechner, S. Melatonin as a chronobiotic: PROS and CONS. Acta Neurobiol.Exp (Warsz.) 1996;56:363-372. View abstract.
  101. Middleton, B. A., Stone, B. M., and Arendt, J. Melatonin and fragmented sleep patterns. Lancet 8-24-1996;348:551-552. View abstract.
  102. Cajochen, C., Krauchi, K., von Arx, M. A., Mori, D., Graw, P., and Wirz-Justice, A. Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neurosci.Lett. 4-5-1996;207:209-213. View abstract.
  103. Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., and Lerner, Y. Brief report: circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. J.Autism Dev.Disord. 1995;25:641-654. View abstract.
  104. Masters, K. J. Melatonin for sleep problems. J Am Acad Child Adolesc Psychiatry 1996;35:704. View abstract.
  105. Luboshitzky, R., Lavi, S., Thuma, I., and Lavie, P. Testosterone treatment alters melatonin concentrations in male patients with gonadotropin-releasing hormone deficiency. J Clin Endocrinol Metab 1996;81:770-774. View abstract.
  106. Attenburrow, M. E., Dowling, B. A., Sharpley, A. L., and Cowen, P. J. Case-control study of evening melatonin concentration in primary insomnia. BMJ 5-18-1996;312:1263-1264. View abstract.
  107. Fiorina, P., Lattuada, G., Ponari, O., Silvestrini, C., and DallAglio, P. Impaired nocturnal melatonin excretion and changes of immunological status in ischaemic stroke patients. Lancet 3-9-1996;347:692-693. View abstract.
  108. Lissoni, P., Meregalli, S., Nosetto, L., Barni, S., Tancini, G., Fossati, V., and Maestroni, G. Increased survival time in brain glioblastomas by a radioneuroendocrine strategy with radiotherapy plus melatonin compared to radiotherapy alone. Oncology 1996;53:43-46. View abstract.
  109. Lehmann, E. D., Cockerell, O. C., and Rudge, P. Somnolence associated with melatonin deficiency after pinealectomy. Lancet 2-3-1996;347:323. View abstract.
  110. Etzioni, A., Luboshitzky, R., Tiosano, D., Ben Harush, M., Goldsher, D., and Lavie, P. Melatonin replacement corrects sleep disturbances in a child with pineal tumor. Neurology 1996;46:261-263. View abstract.
  111. Lissoni, P., Brivio, F., Brivio, O., Fumagalli, L., Gramazio, F., Rossi, M., Emanuelli, G., Alderi, G., and Lavorato, F. Immune effects of preoperative immunotherapy with high-dose subcutaneous interleukin-2 versus neuroimmunotherapy with low-dose interleukin-2 plus the neurohormone melatonin in gastrointestinal tract tumor patients. J Biol Regul.Homeost.Agents 1995;9:31-33. View abstract.
  112. Cagnacci, A., Soldani, R., and Yen, S. S. Melatonin enhances cortisol levels in aged but not young women. Eur.J Endocrinol. 1995;133:691-695. View abstract.
  113. Deacon, S. and Arendt, J. Melatonin-induced temperature suppression and its acute phase-shifting effects correlate in a dose-dependent manner in humans. Brain Res 8-7-1995;688(1-2):77-85. View abstract.
  114. Braczkowski, R., Zubelewicz, B., Romanowski, W., Lissoni, P., and Barni, S. Modulation of tumor necrosis factor-alpha (TNF-alpha) toxicity by the pineal hormone melatonin (MLT) in metastatic solid tumor patients. Ann N Y Acad Sci 9-30-1995;768:334-336. View abstract.
  115. Lissoni, P., Barni, S., Tancini, G., Ardizzoia, A., Rovelli, F., Cazzaniga, M., Brivio, F., Piperno, A., Aldeghi, R., Fossati, D., and . Immunotherapy with subcutaneous low-dose interleukin-2 and the pineal indole melatonin as a new effective therapy in advanced cancers of the digestive tract. Br J Cancer 1993;67:1404-1407. View abstract.
  116. Maestroni, G. J. The immunoneuroendocrine role of melatonin. J.Pineal Res. 1993;14:1-10. View abstract.
  117. Okatani, Y. and Sagara, Y. Role of melatonin in nocturnal prolactin secretion in women with normoprolactinemia and mild hyperprolactinemia. Am J Obstet Gynecol 1993;168(3 Pt 1):854-861. View abstract.
  118. Dollins, A. B., Lynch, H. J., Wurtman, R. J., Deng, M. H., and Lieberman, H. R. Effects of illumination on human nocturnal serum melatonin levels and performance. Physiol Behav. 1993;53:153-160. View abstract.
  119. Lissoni, P., Barni, S., Rovelli, F., Brivio, F., Ardizzoia, A., Tancini, G., Conti, A., and Maestroni, G. J. Neuroimmunotherapy of advanced solid neoplasms with single evening subcutaneous injection of low-dose interleukin-2 and melatonin: preliminary results. Eur J Cancer 1993;29A:185-189. View abstract.
  120. Ekman, A. C., Leppaluoto, J., Huttunen, P., Aranko, K., and Vakkuri, O. Ethanol inhibits melatonin secretion in healthy volunteers in a dose- dependent randomized double blind cross-over study. J Clin Endocrinol Metab 1993;77:780-783. View abstract.
  121. Terzolo, M., Revelli, A., Guidetti, D., Piovesan, A., Cassoni, P., Paccotti, P., Angeli, A., and Massobrio, M. Evening administration of melatonin enhances the pulsatile secretion of prolactin but not of LH and TSH in normally cycling women. Clin Endocrinol (Oxf) 1993;39:185-191. View abstract.
  122. Lissoni, P., Ardizzoia, A., Tisi, E., Rossini, F., Barni, S., Tancini, G., Conti, A., and Maestroni, G. J. Amplification of eosinophilia by melatonin during the immunotherapy of cancer with interleukin-2. J Biol Regul.Homeost.Agents 1993;7:34-36. View abstract.
  123. Pierrefiche, G., Topall, G., Courboin, G., Henriet, I., and Laborit, H. Antioxidant activity of melatonin in mice. Res Commun Chem Pathol.Pharmacol 1993;80:211-223. View abstract.
  124. McIntyre, I. M., Norman, T. R., Burrows, G. D., and Armstrong, S. M. Alterations to plasma melatonin and cortisol after evening alprazolam administration in humans. Chronobiol Int 1993;10:205-213. View abstract.
  125. Hardeland, R., Reiter, R. J., Poeggeler, B., and Tan, D. X. The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances. Neurosci.Biobehav.Rev 1993;17:347-357. View abstract.
  126. Folkard, S., Arendt, J., and Clark, M. Can melatonin improve shift workers' tolerance of the night shift? Some preliminary findings. Chronobiol.Int. 1993;10:315-320. View abstract.
  127. Short, R. V. Melatonin. BMJ 10-16-1993;307:952-953. View abstract.
  128. Cavallo, A. The pineal gland in human beings: relevance to pediatrics. J Pediatr 1993;123:843-851. View abstract.
  129. Lee, P. P. and Pang, S. F. Melatonin and its receptors in the gastrointestinal tract. Biol.Signals 1993;2:181-193. View abstract.
  130. Neri, B., Fiorelli, C., Moroni, F., Nicita, G., Paoletti, M. C., Ponchietti, R., Raugei, A., Santoni, G., Trippitelli, A., and Grechi, G. Modulation of human lymphoblastoid interferon activity by melatonin in metastatic renal cell carcinoma. A phase II study. Cancer 6-15-1994;73:3015-3019. View abstract.
  131. Jan, J. E., Abroms, I. F., Freeman, R. D., Brown, G. M., Espezel, H., and Connolly, M. B. Rapid cycling in severely multidisabled children: a form of bipolar affective disorder? Pediatr Neurol 1994;10:34-39. View abstract.
  132. Deacon, S. and Arendt, J. Posture influences melatonin concentrations in plasma and saliva in humans. Neurosci.Lett 2-14-1994;167(1-2):191-194. View abstract.
  133. Lissoni, P., Brivio, F., Ardizzoia, A., Tancini, G., and Barni, S. Subcutaneous therapy with low-dose interleukin-2 plus the neurohormone melatonin in metastatic gastric cancer patients with low performance status. Tumori 12-31-1993;79:401-404. View abstract.
  134. Monteleone, P., Orazzo, C., Natale, M., and Maj, M. Lack of effect of short-term fluoxetine administration on nighttime plasma melatonin levels in healthy subjects. Biol Psychiatry 1-15-1994;35:139-142. View abstract.
  135. Ferini-Strambi, L., Zucconi, M., Biella, G., Stankov, B., Fraschini, F., Oldani, A., and Smirne, S. Effect of melatonin on sleep microstructure: preliminary results in healthy subjects. Sleep 1993;16:744-747. View abstract.
  136. Aldeghi, R., Lissoni, P., Barni, S., Ardizzoia, A., Tancini, G., Piperno, A., Pozzi, M., Ricci, G., Conti, A., and Maestroni, G. J. Low-dose interleukin-2 subcutaneous immunotherapy in association with the pineal hormone melatonin as a first-line therapy in locally advanced or metastatic hepatocellular carcinoma. Eur J Cancer 1994;30A:167-170. View abstract.
  137. Jan, J. E., Espezel, H., and Appleton, R. E. The treatment of sleep disorders with melatonin. Dev.Med Child Neurol 1994;36:97-107. View abstract.
  138. Viggiano, S. R., Koskela, T. K., Klee, G. G., Samples, J. R., Arnce, R., and Brubaker, R. F. The effect of melatonin on aqueous humor flow in humans during the day. Ophthalmology 1994;101:326-331. View abstract.
  139. Zaidan, R., Geoffriau, M., Brun, J., Taillard, J., Bureau, C., Chazot, G., and Claustrat, B. Melatonin is able to influence its secretion in humans: description of a phase-response curve. Neuroendocrinology 1994;60:105-112. View abstract.
  140. Lissoni, P., Barni, S., Ardizzoia, A., Olivini, G., Brivio, F., Tisi, E., Tancini, G., Characiejus, D., and Kothari, L. Cancer immunotherapy with low-dose interleukin-2 subcutaneous administration: potential efficacy in most solid tumor histotypes by a concomitant treatment with the pineal hormone melatonin. J Biol Regul Homeost.Agents 1993;7:121-125. View abstract.
  141. Czeisler, C. A., Shanahan, T. L., Klerman, E. B., Martens, H., Brotman, D. J., Emens, J. S., Klein, T., and Rizzo, J. F., III. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med 1-5-1995;332:6-11. View abstract.
  142. Danilenko, K. V., Putilov, A. A., Russkikh, G. S., Duffy, L. K., and Ebbesson, S. O. Diurnal and seasonal variations of melatonin and serotonin in women with seasonal affective disorder. Arctic Med Res 1994;53:137-145. View abstract.
  143. Becker-Andre, M., Wiesenberg, I., Schaeren-Wiemers, N., Andre, E., Missbach, M., Saurat, J. H., and Carlberg, C. Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily. J Biol Chem 11-18-1994;269:28531-28534. View abstract.
  144. Harma, M., Laitinen, J., Partinen, M., and Suvanto, S. The effect of four-day round trip flights over 10 time zones on the circadian variation of salivary melatonin and cortisol in airline flight attendants. Ergonomics 1994;37:1479-1489. View abstract.
  145. Poon, A. M., Liu, Z. M., Pang, C. S., Brown, G. M., and Pang, S. F. Evidence for a direct action of melatonin on the immune system. Biol Signals 1994;3:107-117. View abstract.
  146. Pieri, C., Marra, M., Moroni, F., Recchioni, R., and Marcheselli, F. Melatonin: a peroxyl radical scavenger more effective than vitamin E. Life Sci 1994;55:L271-L276. View abstract.
  147. Oren, D. A., Turner, E. H., and Wehr, T. A. Abnormal circadian rhythms of plasma melatonin and body temperature in the delayed sleep phase syndrome. J Neurol Neurosurg Psychiatry 1995;58:379. View abstract.
  148. Jan, J. E. and Espezel, H. Melatonin treatment of chronic sleep disorders. Dev.Med Child Neurol 1995;37:279-280. View abstract.
  149. Cardinali, D. P., Del Zar, M. M., and Vacas, M. I. The effects of melatonin in human platelets. Acta Physiol Pharmacol Ther Latinoam. 1993;43(1-2):1-13. View abstract.
  150. Rommel, T. and Demisch, L. Influence of chronic beta-adrenoreceptor blocker treatment on melatonin secretion and sleep quality in patients with essential hypertension. J Neural Transm.Gen.Sect. 1994;95:39-48. View abstract.
  151. Lissoni, P., Barni, S., Tancini, G., Mainini, E., Piglia, F., Maestroni, G. J., and Lewinski, A. Immunoendocrine therapy with low-dose subcutaneous interleukin-2 plus melatonin of locally advanced or metastatic endocrine tumors. Oncology 1995;52:163-166. View abstract.
  152. Tzischinsky, O. and Lavie, P. Melatonin possesses time-dependent hypnotic effects. Sleep 1994;17:638-645. View abstract.
  153. Lee, B. J., Parrott, K. A., Ayres, J. W., and Sack, R. L. Preliminary evaluation of transdermal delivery of melatonin in human subjects. Res Commun Mol Pathol.Pharmacol 1994;85:337-346. View abstract.
  154. Deacon, S., English, J., and Arendt, J. Acute phase-shifting effects of melatonin associated with suppression of core body temperature in humans. Neurosci.Lett. 8-29-1994;178:32-34. View abstract.
  155. Reiter, R. J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L., Chuang, J., Ortiz, G. G., and Acuna-Castroviejo, D. A review of the evidence supporting melatonin's role as an antioxidant. J Pineal Res 1995;18:1-11. View abstract.
  156. Fideleff, H., Aparicio, N. J., Guitelman, A., Debeljuk, L., Mancini, A., and Cramer, C. Effect of melatonin on the basal and stimulated gonadotropin levels in normal men and postmenopausal women. J Clin Endocrinol Metab 1976;42:1014-1017. View abstract.
  157. Dawson, D., Encel, N., and Lushington, K. Improving adaptation to simulated night shift: timed exposure to bright light versus daytime melatonin administration. Sleep 1995;18:11-21. View abstract.
  158. Brugger, P., Marktl, W., and Herold, M. Impaired nocturnal secretion of melatonin in coronary heart disease. Lancet 6-3-1995;345:1408. View abstract.
  159. Brackowski, R., Zubelewicz, B., Romanowski, W., Lissoni, P., Barni, S., Tancini, G., and Maestroni, G. J. Preliminary study on modulation of the biological effects of tumor necrosis factor-alpha in advanced cancer patients by the pineal hormone melatonin. J Biol Regul Homeost.Agents 1994;8:77-80. View abstract.
  160. Childs, P. A., Rodin, I., Martin, N. J., Allen, N. H., Plaskett, L., Smythe, P. J., and Thompson, C. Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls. Br J Psychiatry 1995;166:196-198. View abstract.
  161. Cagnacci, A., Soldani, R., and Yen, S. S. Exogenous melatonin enhances luteinizing hormone levels of women in the follicular but not in the luteal menstrual phase. Fertil.Steril. 1995;63:996-999. View abstract.
  162. Barni, S., Lissoni, P., Cazzaniga, M., Ardizzoia, A., Meregalli, S., Fossati, V., Fumagalli, L., Brivio, F., and Tancini, G. A randomized study of low-dose subcutaneous interleukin-2 plus melatonin versus supportive care alone in metastatic colorectal cancer patients progressing under 5-fluorouracil and folates. Oncology 1995;52:243-245. View abstract.
  163. Cagnacci, A., Paoletti, A. M., Soldani, R., Orru, M., Maschio, E., and Melis, G. B. Melatonin enhances the luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the follicular, but not in the luteal, menstrual phase. J Clin Endocrinol Metab 1995;80:1095-1099. View abstract.
  164. Lissoni, P., Barni, S., Fossati, V., Ardizzoia, A., Cazzaniga, M., Tancini, G., and Frigerio, F. A randomized study of neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin compared to supportive care alone in patients with untreatable metastatic solid tumour. Support.Care Cancer 1995;3:194-197. View abstract.
  165. Molis, T. M., Spriggs, L. L., Jupiter, Y., and Hill, S. M. Melatonin modulation of estrogen-regulated proteins, growth factors, and proto-oncogenes in human breast cancer. J Pineal Res 1995;18:93-103. View abstract.
  166. Haimov, I. and Lavie, P. Potential of melatonin replacement therapy in older patients with sleep disorders. Drugs Aging 1995;7:75-78. View abstract.
  167. Lapierre, O. and Dumont, M. Melatonin treatment of a non-24-hour sleep-wake cycle in a blind retarded child. Biol Psychiatry 7-15-1995;38:119-122. View abstract.
  168. Vijayalaxmi, Reiter, R. J., and Meltz, M. L. Melatonin protects human blood lymphocytes from radiation-induced chromosome damage. Mutat.Res 1995;346:23-31. View abstract.
  169. Wurtman, R. J. and Zhdanova, I. Improvement of sleep quality by melatonin. Lancet 12-2-1995;346:1491. View abstract.
  170. Lockley, S., Tabandeh, H., Skene, D., Buttery, R., Bird, A., Defrace, R., and Arendt, J. Day-time naps and melatonin in blind people. Lancet 12-2-1995;346:1491. View abstract.
  171. Lewy, A. J., Wehr, T. A., Goodwin, F. K., Newsome, D. A., and Markey, S. P. Light suppresses melatonin secretion in humans. Science 12-12-1980;210:1267-1269. View abstract.
  172. Weinberg, U., Weitzman, E. D., Horowitz, Z. D., and Burg, A. C. Lack of an effect of melatonin on the basal and L-dopa stimulated growth hormone secretion in men. J Neural Transm. 1981;52(1-2):117-121. View abstract.
  173. Hanssen, T., Heyden, T., Sundberg, I., and Wetterberg, L. Effect of propranolol on serum-melatonin. Lancet 8-6-1977;2:309-310. View abstract.
  174. Weinberg, U., Weitzman, E. D., Fukushima, D. K., Cancel, G. F., and Rosenfeld, R. S. Melatonin does not suppress the pituitary luteinizing hormone response to luteinizing hormone-releasing hormone in men. J Clin Endocrinol Metab 1980;51:161-162. View abstract.
  175. Cowen, P. J., Fraser, S., Sammons, R., and Green, A. R. Atenolol reduces plasma melatonin concentration in man. Br J Clin Pharmacol 1983;15:579-581. View abstract.
  176. Lewy, A. J. and Newsome, D. A. Different types of melatonin circadian secretory rhythms in some blind subjects. J Clin Endocrinol Metab 1983;56:1103-1107. View abstract.
  177. Arendt, J., Borbely, A. A., Franey, C., and Wright, J. The effects of chronic, small doses of melatonin given in the late afternoon on fatigue in man: a preliminary study. Neurosci.Lett 4-6-1984;45:317-321. View abstract.
  178. Danforth, D. N., Jr., Tamarkin, L., and Lippman, M. E. Melatonin increases oestrogen receptor binding activity of human breast cancer cells. Nature 9-22-1983;305:323-325. View abstract.
  179. Wetterberg, L., Eriksson, O., Friberg, Y., and Vangbo, B. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half-life of plasma melatonin in man. Clin Chim.Acta 1978;86:169-177. View abstract.
  180. Lieberman, H. R., Waldhauser, F., Garfield, G., Lynch, H. J., and Wurtman, R. J. Effects of melatonin on human mood and performance. Brain Res 12-10-1984;323:201-207. View abstract.
  181. Aleem, F. A., Weitzman, E. D., and Weinberg, U. Suppression of basal luteinizing hormone concentrations by melatonin in postmenopausal women. Fertil.Steril. 1984;42:923-925. View abstract.
  182. Waldhauser, F., Waldhauser, M., Lieberman, H. R., Deng, M. H., Lynch, H. J., and Wurtman, R. J. Bioavailability of oral melatonin in humans. Neuroendocrinology 1984;39:307-313. View abstract.
  183. Waldhauser, F., Weiszenbacher, G., Frisch, H., Zeitlhuber, U., Waldhauser, M., and Wurtman, R. J. Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet 2-18-1984;1:362-365. View abstract.
  184. Fariello, R. G., Bubenik, G. A., Brown, G. M., and Grota, L. J. Epileptogenic action of intraventricularly injected antimelatonin antibody. Neurology 1977;27:567-570. View abstract.
  185. Papavasiliou, P. S., Cotzias, G. C., Duby, S. E., Steck, A. J., Bell, M., and Lawrence, W. H. Melatonin and parkinsonism. JAMA 7-3-1972;221:88-89. View abstract.
  186. Smythe, G. A. and Lazarus, L. Growth hormone responses to melatonin in man. Science 6-28-1974;184:1373-1374. View abstract.
  187. Smythe, G. A. and Lazarus, L. Suppression of human growth hormone secretion by melatonin and cyproheptadine. J Clin Invest 1974;54:116-121. View abstract.
  188. Smythe, G. A. and Lazarus, L. Growth hormone regulation by melatonin and serotonin. Nature 7-27-1973;244:230-231. View abstract.
  189. Cramer, H., Rudolph, J., Consbruch, U., and Kendel, K. On the effects of melatonin on sleep and behavior in man. Adv Biochem Psychopharmacol 1974;11:187-191. View abstract.
  190. Shaw, K. M., Stern, G. M., and Sandler, M. Melatonin and parkinsonism [abstract]. Lancet 2-3-1973;1:271. View abstract.
  191. Lane, E. A. and Moss, H. B. Pharmacokinetics of melatonin in man: first pass hepatic metabolism. J Clin Endocrinol Metab 1985;61:1214-1216. View abstract.
  192. Sherer, M. A., Weingartner, H., James, S. P., and Rosenthal, N. E. Effects of melatonin on performance testing in patients with seasonal affective disorder. Neurosci.Lett 8-5-1985;58:277-282. View abstract.
  193. Danforth, D. N., Jr., Tamarkin, L., Mulvihill, J. J., Bagley, C. S., and Lippman, M. E. Plasma melatonin and the hormone-dependency of human breast cancer. J Clin Oncol 1985;3:941-948. View abstract.
  194. Aldhous, M., Franey, C., Wright, J., and Arendt, J. Plasma concentrations of melatonin in man following oral absorption of different preparations. Br J Clin Pharmacol 1985;19:517-521. View abstract.
  195. Wurtman, R. J. Melatonin as a hormone in humans: a history. Yale J Biol.Med 1985;58:547-552. View abstract.
  196. Wetterberg, L. Melatonin in humans physiological and clinical studies. J Neural Transm.Suppl 1978;:289-310. View abstract.
  197. Reiter, R. J., Rollag, M. D., Panke, E. S., and Banks, A. F. Melatonin: reproductive effects. J Neural Transm.Suppl 1978;:209-223. View abstract.
  198. Waldhauser, F., Vierhapper, H., and Pirich, K. Abnormal circadian melatonin secretion in night-shift workers. N.Engl.J Med 12-18-1986;315:1614. View abstract.
  199. Sack, R. L., Lewy, A. J., Erb, D. L., Vollmer, W. M., and Singer, C. M. Human melatonin production decreases with age. J Pineal Res 1986;3:379-388. View abstract.
  200. Claustrat, B., Brun, J., Garry, P., Roussel, B., and Sassolas, G. A once-repeated study of nocturnal plasma melatonin patterns and sleep recordings in six normal young men. J Pineal Res 1986;3:301-310. View abstract.
  201. Wright, J., Aldhous, M., Franey, C., English, J., and Arendt, J. The effects of exogenous melatonin on endocrine function in man. Clin Endocrinol (Oxf) 1986;24:375-382. View abstract.
  202. Franey, C., Aldhous, M., Burton, S., Checkley, S., and Arendt, J. Acute treatment with desipramine stimulates melatonin and 6-sulphatoxy melatonin production in man. Br J Clin Pharmacol 1986;22:73-79. View abstract.
  203. Bojkowski, C. J., Arendt, J., Shih, M. C., and Markey, S. P. Melatonin secretion in humans assessed by measuring its metabolite, 6- sulfatoxymelatonin. Clin Chem 1987;33:1343-1348. View abstract.
  204. James, S. P., Mendelson, W. B., Sack, D. A., Rosenthal, N. E., and Wehr, T. A. The effect of melatonin on normal sleep. Neuropsychopharmacology 1987;1:41-44. View abstract.
  205. Cavallo, A., Richards, G. E., Meyer, W. J., III, and Waldrop, R. D. Evaluation of 5-hydroxytryptophan administration as a test of pineal function in humans. Horm Res 1987;27:69-73. View abstract.
  206. Blask, D. E. and Hill, S. M. Effects of melatonin on cancer: studies on MCF-7 human breast cancer cells in culture. J Neural Transm.Suppl 1986;21:433-449. View abstract.
  207. Rosenthal, N. E., Sack, D. A., Jacobsen, F. M., James, S. P., Parry, B. L., Arendt, J., Tamarkin, L., and Wehr, T. A. Melatonin in seasonal affective disorder and phototherapy. J Neural Transm.Suppl 1986;21:257-267. View abstract.
  208. Lieberman, H. R. Behavior, sleep and melatonin. J Neural Transm.Suppl 1986;21:233-241. View abstract.
  209. Nowak, R., McMillen, I. C., Redman, J., and Short, R. V. The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity. Clin Endocrinol (Oxf) 1987;27:445-452. View abstract.
  210. Samples, J. R., Krause, G., and Lewy, A. J. Effect of melatonin on intraocular pressure. Curr Eye Res 1988;7:649-653. View abstract.
  211. Esposti, D., Lissoni, P., Mauri, R., Rovelli, F., Orsenigo, L., Pescia, S., Vegetti, G., Esposti, G., and Fraschini, F. The pineal gland-opioid system relation: melatonin-naloxone interactions in regulating GH and LH releases in man. J Endocrinol Invest 1988;11:103-106. View abstract.
  212. Regelson, W. and Pierpaoli, W. Melatonin: a rediscovered antitumor hormone? Its relation to surface receptors; sex steroid metabolism, immunologic response, and chronobiologic factors in tumor growth and therapy. Cancer Invest 1987;5:379-385. View abstract.
  213. Reiter, R. J. The melatonin message: duration versus coincidence hypotheses. Life Sci 6-1-1987;40:2119-2131. View abstract.
  214. Brismar, K., Hylander, B., Eliasson, K., Rossner, S., and Wetterberg, L. Melatonin secretion related to side-effects of beta-blockers from the central nervous system. Acta Med Scand 1988;223:525-530. View abstract.
  215. Valcavi, R., Dieguez, C., Azzarito, C., Edwards, C. A., Dotti, C., Page, M. D., Portioli, I., and Scanlon, M. F. Effect of oral administration of melatonin on GH responses to GRF 1-44 in normal subjects. Clin Endocrinol (Oxf) 1987;26:453-458. View abstract.
  216. Waldhauser, F., Lieberman, H. R., Lynch, H. J., Waldhauser, M., Herkner, K., Frisch, H., Vierhapper, H., Waldhausl, W., Schemper, M., Wurtman, R. J., and . A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol. Neuroendocrinology 1987;46:125-130. View abstract.
  217. Arendt, J., Aldhous, M., and Marks, V. Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. Br.Med J (Clin Res Ed) 5-3-1986;292:1170. View abstract.
  218. Maestroni, G. J., Conti, A., and Pierpaoli, W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol. 1986;13:19-30. View abstract.
  219. Arendt, J., Aldhous, M., and Wright, J. Synchronisation of a disturbed sleep-wake cycle in a blind man by melatonin treatment. Lancet 4-2-1988;1:772-773. View abstract.
  220. Wurtman, R. J. and Ozaki, Y. Physiological control of melatonin synthesis and secretion: mechanisms, generating rhythms in melatonin, methoxytryptophol, and arginine vasotocin levels and effects on the pineal of endogenous catecholamines, the estrous cycle, and environmental lighting. J Neural Transm.Suppl 1978;:59-70. View abstract.
  221. Lewy, A. J., Siever, L. J., Uhde, T. W., and Markey, S. P. Clonidine reduces plasma melatonin levels. J Pharm Pharmacol 1986;38:555-556. View abstract.
  222. Cowen, P. J., Bevan, J. S., Gosden, B., and Elliott, S. A. Treatment with beta-adrenoceptor blockers reduces plasma melatonin concentration. Br J Clin Pharmacol 1985;19:258-260. View abstract.
  223. Paccotti, P., Terzolo, M., Torta, M., Vignani, A., Schena, M., Piovesan, A., and Angeli, A. Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males. J Endocrinol Invest 1987;10:471-477. View abstract.
  224. Winton, F., Corn, T., Huson, L. W., Franey, C., Arendt, J., and Checkley, S. A. Effects of light treatment upon mood and melatonin in patients with seasonal affective disorder. Psychol Med 1989;19:585-590. View abstract.
  225. Nickelsen, T., Demisch, L., Demisch, K., Radermacher, B., and Schoffling, K. Influence of subchronic intake of melatonin at various times of the day on fatigue and hormonal levels: a placebo-controlled, double-blind trial. J Pineal Res 1989;6:325-334. View abstract.
  226. Ozaki, Y., Wurtman, R. J., Alonso, R., and Lynch, H. J. Melatonin secretion decreases during the proestrous stage of the rat estrous cycle. Proc Natl Acad Sci U S A 1978;75:531-534. View abstract.
  227. Monteleone, P., Forziati, D., Orazzo, C., and Maj, M. Preliminary observations on the suppression of nocturnal plasma melatonin levels by short-term administration of diazepam in humans. J Pineal Res 1989;6:253-258. View abstract.
  228. Ferrari, E., Foppa, S., Bossolo, P. A., Comis, S., Esposti, G., Licini, V., Fraschini, F., and Brambilla, F. Melatonin and pituitary-gonadal function in disorders of eating behavior. J Pineal Res 1989;7:115-124. View abstract.
  229. Stewart, J. W. and Halbreich, U. Plasma melatonin levels in depressed patients before and after treatment with antidepressant medication. Biol Psychiatry 1989;25:33-38. View abstract.
  230. Palazidou, E., Papadopoulos, A., Sitsen, A., Stahl, S., and Checkley, S. An alpha 2 adrenoceptor antagonist, Org 3770, enhances nocturnal melatonin secretion in man. Psychopharmacology (Berl) 1989;97:115-117. View abstract.
  231. Palazidou, E., Franey, C., Arendt, J., Stahl, S., and Checkley, S. Evidence for a functional role of alpha-1 adrenoceptors in the regulation of melatonin secretion in man. Psychoneuroendocrinology 1989;14(1-2):131-135. View abstract.
  232. Viviani, S., Negretti, E., Orazi, A., Sozzi, G., Santoro, A., Lissoni, P., Esposti, G., and Fraschini, F. Preliminary studies on melatonin in the treatment of myelodysplastic syndromes following cancer chemotherapy. J Pineal Res 1990;8:347-354. View abstract.
  233. Folkard, S., Arendt, J., Aldhous, M., and Kennett, H. Melatonin stabilises sleep onset time in a blind man without entrainment of cortisol or temperature rhythms. Neurosci.Lett 5-31-1990;113:193-198. View abstract.
  234. Vacas, M. I. and Cardinali, D. P. Diurnal changes in melatonin binding sites of hamster and rat brains. Correlations with neuroendocrine responsiveness to melatonin. Neurosci Lett 1979;15(2-3):259-263. View abstract.
  235. Malow, B. A., Byars, K., Johnson, K., Weiss, S., Bernal, P., Goldman, S. E., Panzer, R., Coury, D. L., and Glaze, D. G. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics 2012;130 Suppl 2:S106-S124. View abstract.
  236. de Leiva, A., Tortosa, F., Peinado, M. A., Serrano, J., Rodriguez-Espinosa, J., and Puig-Domingo, M. Episodic nyctohemeral secretion of melatonin in adult humans: lack of relation with LH pulsatile pattern. Acta Endocrinol (Copenh) 1990;122:76-82. View abstract.
  237. Lissoni, P., Brivio, F., Barni, S., Tancini, G., Cattaneo, G., Archili, C., Conti, A., and Maestroni, G. J. Neuroimmunotherapy of human cancer with interleukin-2 and the neurohormone melatonin: its efficacy in preventing hypotension. Anticancer Res 1990;10:1759-1761. View abstract.
  238. Shatilo, V. B., Bondarenko, E. V., and Antoniuk-Shcheglova, I. A. [Metabolic disorders in elderly patients with hypertension and their correction with melatonin]. Adv.Gerontol. 2012;25:84-89. View abstract.
  239. Brigo, F. and Del, Felice A. Melatonin as add-on treatment for epilepsy. Cochrane.Database.Syst.Rev. 2012;6:CD006967. View abstract.
  240. Zamotaev, IuN. [The use of melatonin for correction of sleep disturbances in assembly-line shift workers with arterial hypertension]. Klin.Med.(Mosk) 2012;90:44-46. View abstract.
  241. Yiannakopoulou, E., Nikiteas, N., Perrea, D., and Tsigris, C. Pharmacological modulation of oxidative stress response in minimally invasive surgery: systematic review. Surg.Laparosc.Endosc.Percutan.Tech. 2012;22:200-204. View abstract.
  242. Di, Bella G. and Colori, B. The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 23 tumours of the head and neck. Neuro.Endocrinol.Lett. 2012;33:249-256. View abstract.
  243. Mantele, S., Otway, D. T., Middleton, B., Bretschneider, S., Wright, J., Robertson, M. D., Skene, D. J., and Johnston, J. D. Daily rhythms of plasma melatonin, but not plasma leptin or leptin mRNA, vary between lean, obese and type 2 diabetic men. PLoS.One. 2012;7:e37123. View abstract.
  244. Anderson, G. and Maes, M. Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects. Metab Brain Dis. 2012;27:113-119. View abstract.
  245. de Matos, Cavalcante A. G., de Bruin, P. F., de Bruin, V. M., Nunes, D. M., Pereira, E. D., Cavalcante, M. M., and Andrade, G. M. Melatonin reduces lung oxidative stress in patients with chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled study. J.Pineal Res. 2012;53:238-244. View abstract.
  246. Gonciarz, M., Gonciarz, Z., Bielanski, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., and Konturek, S. J. The effects of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. J.Physiol Pharmacol. 2012;63:35-40. View abstract.
  247. Pullman, R. E., Roepke, S. E., and Duffy, J. F. Laboratory validation of an in-home method for assessing circadian phase using dim light melatonin onset (DLMO). Sleep Med. 2012;13:703-706. View abstract.
  248. No author. [Relationship between insulin, leptin, and melatonin contents in patients with metabolic syndrome]. Klin.Med.(Mosk) 2011;89:46-49. View abstract.
  249. Schernhammer, E. S., Giobbie-Hurder, A., Gantman, K., Savoie, J., Scheib, R., Parker, L. M., and Chen, W. Y. A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers. Cancer Causes Control 2012;23:609-616. View abstract.
  250. Otmani, S., Metzger, D., Guichard, N., Danjou, P., Nir, T., Zisapel, N., and Katz, A. Effects of prolonged-release melatonin and zolpidem on postural stability in older adults. Hum.Psychopharmacol. 2012;27:270-276. View abstract.
  251. Gooneratne, N. S., Edwards, A. Y., Zhou, C., Cuellar, N., Grandner, M. A., and Barrett, J. S. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J.Pineal Res. 2012;52:437-445. View abstract.
  252. Rondanelli, M., Opizzi, A., Faliva, M., Mozzoni, M., Antoniello, N., Cazzola, R., Savare, R., Cerutti, R., Grossi, E., and Cestaro, B. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutr.Neurosci. 2012;15:46-54. View abstract.
  253. Ucar, E., Lehtinen, E. K., Glenthoj, B. Y., and Oranje, B. The effect of acute exogenous melatonin on P50 suppression in healthy male volunteers stratified for low and high gating levels. J.Psychopharmacol. 2012;26:1113-1118. View abstract.
  254. Laakso, M. L., Porkka-Heiskanen, T., Alila, A., Stenberg, D., and Johansson, G. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J Pineal Res 1990;9:39-50. View abstract.
  255. Wang, Y. M., Jin, B. Z., Ai, F., Duan, C. H., Lu, Y. Z., Dong, T. F., and Fu, Q. L. The efficacy and safety of melatonin in concurrent chemotherapy or radiotherapy for solid tumors: a meta-analysis of randomized controlled trials. Cancer Chemother.Pharmacol. 2012;69:1213-1220. View abstract.
  256. Rechcinski, T., Uznanska-Loch, B., Trzos, E., Wierzbowska-Drabik, K., Krzeminska-Pakula, M., Kasprzak, J. D., and Kurpesa, M. Melatonin - a somniferous option which does not aggravate sleep-disordered breathing in cardiac risk patients: a Holter ECG based study. Kardiol.Pol. 2012;70:24-29. View abstract.
  257. Sekeroglu, M. R., Huyut, Z., and Him, A. The susceptibility of erythrocytes to oxidation during storage of blood: effects of melatonin and propofol. Clin.Biochem. 2012;45(4-5):315-319. View abstract.
  258. Livianos, L., Sierra, P., Arques, S., Garcia, A., and Rojo, L. Is melatonin an adjunctive stabilizer? Psychiatry Clin.Neurosci. 2012;66:82-83. View abstract.
  259. Kotlarczyk, M. P., Lassila, H. C., O'Neil, C. K., D'Amico, F., Enderby, L. T., Witt-Enderby, P. A., and Balk, J. L. Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. J.Pineal Res. 2012;52:414-426. View abstract.
  260. Maldonado, M. D., Manfredi, M., Ribas-Serna, J., Garcia-Moreno, H., and Calvo, J. R. Melatonin administrated immediately before an intense exercise reverses oxidative stress, improves immunological defenses and lipid metabolism in football players. Physiol Behav. 3-20-2012;105:1099-1103. View abstract.
  261. Celinski, K., Konturek, P. C., Konturek, S. J., Slomka, M., Cichoz-Lach, H., Brzozowski, T., and Bielanski, W. Effects of melatonin and tryptophan on healing of gastric and duodenal ulcers with Helicobacter pylori infection in humans. J.Physiol Pharmacol. 2011;62:521-526. View abstract.
  262. Di, Bella G. The Di Bella Method (DBM) improved survival, objective response and performance status in a retrospective observational clinical study on 122 cases of breast cancer. Neuro.Endocrinol.Lett. 2011;32:751-762. View abstract.
  263. Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., and Burnette, C. Melatonin for sleep in children with autism: a controlled trial examining dose, tolerability, and outcomes. J.Autism Dev.Disord. 2012;42:1729-1737. View abstract.
  264. Gitto, E., Aversa, S., Salpietro, C. D., Barberi, I., Arrigo, T., Trimarchi, G., Reiter, R. J., and Pellegrino, S. Pain in neonatal intensive care: role of melatonin as an analgesic antioxidant. J.Pineal Res. 2012;52:291-295. View abstract.
  265. Karadas, O., Ipekdal, I. H., Ulas, U. H., and Odabasi, Z. Nocturnal headache associated with melatonin deficiency due to a pineal gland cyst. J.Clin.Neurosci. 2012;19:330-332. View abstract.
  266. Wirz-Justice, A., Graw, P., Krauchi, K., Gisin, B., Arendt, J., Aldhous, M., and Poldinger, W. Morning or night-time melatonin is ineffective in seasonal affective disorder. J Psychiatr.Res 1990;24:129-137. View abstract.
  267. Friedman, O., Orvieto, R., Fisch, B., Felz, C., Freud, E., Ben-Haroush, A., and Abir, R. Possible improvements in human ovarian grafting by various host and graft treatments. Hum.Reprod. 2012;27:474-482. View abstract.
  268. Khan, S., Heussler, H., McGuire, T., Dakin, C., Pache, D., Cooper, D., Norris, R., Flenady, V., and Charles, B. Melatonin for non-respiratory sleep disorders in visually impaired children. Cochrane.Database.Syst.Rev. 2011;:CD008473. View abstract.
  269. Cerminara, C., Compagnone, E., Coniglio, A., Margiotta, M., Curatolo, P., Villa, M. P., and Parisi, P. Hypnic headache in children. Cephalalgia 2011;31:1673-1676. View abstract.
  270. Seppi, K., Weintraub, D., Coelho, M., Perez-Lloret, S., Fox, S. H., Katzenschlager, R., Hametner, E. M., Poewe, W., Rascol, O., Goetz, C. G., and Sampaio, C. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson's disease. Mov Disord. 2011;26 Suppl 3:S42-S80. View abstract.
  271. Bukowska, A. [Anticarcinogenic role of melatonin--potential mechanisms]. Med.Pr 2011;62:425-434. View abstract.
  272. Baandrup, L., Fagerlund, B., Jennum, P., Lublin, H., Hansen, J. L., Winkel, P., Gluud, C., Oranje, B., and Glenthoj, B. Y. Prolonged-release melatonin versus placebo for benzodiazepine discontinuation in patients with schizophrenia: a randomized clinical trial - the SMART trial protocol. BMC.Psychiatry 2011;11:160. View abstract.
  273. Grossman, E., Laudon, M., and Zisapel, N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc.Health Risk Manag. 2011;7:577-584. View abstract.
  274. Castro, F., Carrizo, E., Prieto de, Rincon D., Rincon, C. A., Asian, T., Medina-Leendertz, S., and Bonilla, E. Effectiveness of melatonin in tardive dyskinesia. Invest Clin. 2011;52:252-260. View abstract.
  275. Merks, B. T., Burger, H., Willemsen, J., van Gool, J. D., and de Jong, T. P. Melatonin treatment in children with therapy-resistant monosymptomatic nocturnal enuresis. J.Pediatr.Urol. 2012;8:416-420. View abstract.
  276. van, Maanen A., Meijer, A. M., Smits, M. G., and Oort, F. J. Termination of short term melatonin treatment in children with delayed Dim Light Melatonin Onset: effects on sleep, health, behavior problems, and parenting stress. Sleep Med. 2011;12:875-879. View abstract.
  277. Huston, B., Mills, K., Froloff, V., and McGee, M. Bladder rupture after intentional medication overdose. Am.J.Forensic Med.Pathol. 2012;33:184-185. View abstract.
  278. Chojnacki, C., Wisniewska-Jarosinska, M., Walecka-Kapica, E., Klupinska, G., Jaworek, J., and Chojnacki, J. Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis. J.Physiol Pharmacol. 2011;62:327-334. View abstract.
  279. Hurtuk, A., Dome, C., Holloman, C. H., Wolfe, K., Welling, D. B., Dodson, E. E., and Jacob, A. Melatonin: can it stop the ringing? Ann.Otol.Rhinol.Laryngol. 2011;120:433-440. View abstract.
  280. Batioglu, A. S., Sahin, U., Gurlek, B., Ozturk, N., and Unsal, E. The efficacy of melatonin administration on oocyte quality. Gynecol.Endocrinol. 2012;28:91-93. View abstract.
  281. Eryilmaz, O. G., Devran, A., Sarikaya, E., Aksakal, F. N., Mollamahmutoglu, L., and Cicek, N. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems. J.Assist.Reprod.Genet. 2011;28:815-820. View abstract.
  282. de, Jonghe A., van Munster, B. C., van Oosten, H. E., Goslings, J. C., Kloen, P., van, Rees C., Wolvius, R., van, Velde R., Levi, M. M., Korevaar, J. C., and de Rooij, S. E. The effects of melatonin versus placebo on delirium in hip fracture patients: study protocol of a randomised, placebo-controlled, double blind trial. BMC.Geriatr. 2011;11:34. View abstract.
  283. De, Leersnyder H., Zisapel, N., and Laudon, M. Prolonged-release melatonin for children with neurodevelopmental disorders. Pediatr.Neurol. 2011;45:23-26. View abstract.
  284. Hidalgo, M. P., Caumo, W., Dantas, G., Franco, D. G., Torres, I. L., Pezzi, J., Elisabetsky, E., Detanico, B. C., Piato, A., and Markus, R. P. 6-Sulfatoxymelatonin as a predictor of clinical outcome in depressive patients. Hum.Psychopharmacol. 2011;26:252-257. View abstract.
  285. Sherk, Y., Smith, B. A., and Miller, B. D. Liquid melatonin via gastrostomy as an alternative hypnotic in a child with pervasive developmental disorder. J.Child Adolesc.Psychopharmacol. 2011;21:291-293. View abstract.
  286. Ochoa, J. J., Diaz-Castro, J., Kajarabille, N., Garcia, C., Guisado, I. M., De, Teresa C., and Guisado, R. Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males. J.Pineal Res. 2011;51:373-380. View abstract.
  287. Taketani, T., Tamura, H., Takasaki, A., Lee, L., Kizuka, F., Tamura, I., Taniguchi, K., Maekawa, R., Asada, H., Shimamura, K., Reiter, R. J., and Sugino, N. Protective role of melatonin in progesterone production by human luteal cells. J.Pineal Res. 2011;51:207-213. View abstract.
  288. Rossignol, D. A. and Frye, R. E. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev.Med.Child Neurol. 2011;53:783-792. View abstract.
  289. Rakhimova, O. I. [Use of melatonin in combined treatment for inflammatory bowel diseases]. Ter.Arkh. 2010;82:64-68. View abstract.
  290. Chahbouni, M., Escames, G., Lopez, L. C., Sevilla, B., Doerrier, C., Munoz-Hoyos, A., Molina-Carballo, A., and Acuna-Castroviejo, D. Melatonin treatment counteracts the hyperoxidative status in erythrocytes of patients suffering from Duchenne muscular dystrophy. Clin.Biochem. 2011;44(10-11):853-858. View abstract.
  291. Khan, S. A., Heussler, H., McGuire, T., Dakin, C., Pache, D., Norris, R., Cooper, D., and Charles, B. Therapeutic options in the management of sleep disorders in visually impaired children: a systematic review. Clin.Ther. 2011;33:168-181. View abstract.
  292. Nickkholgh, A., Schneider, H., Sobirey, M., Venetz, W. P., Hinz, U., Pelzl, le H., Gotthardt, D. N., Cekauskas, A., Manikas, M., Mikalauskas, S., Mikalauskene, L., Bruns, H., Zorn, M., Weigand, M. A., Buchler, M. W., and Schemmer, P. The use of high-dose melatonin in liver resection is safe: first clinical experience. J.Pineal Res. 2011;50:381-388. View abstract.
  293. Unfer, V., Raffone, E., Rizzo, P., and Buffo, S. Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study. Gynecol.Endocrinol. 2011;27:857-861. View abstract.
  294. El-Batch, M., Hassan, A. M., and Mahmoud, H. A. Taurine is more effective than melatonin on cytochrome P450 2E1 and some oxidative stress markers in streptozotocin-induced diabetic rats. J Agric.Food Chem 5-11-2011;59:4995-5000. View abstract.
  295. Guenole, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., and Baleyte, J. M. Melatonin for disordered sleep in individuals with autism spectrum disorders: systematic review and discussion. Sleep Med.Rev. 2011;15:379-387. View abstract.
  296. Celinski, K., Konturek, S. J., Konturek, P. C., Brzozowski, T., Cichoz-Lach, H., Slomka, M., Malgorzata, P., Bielanski, W., and Reiter, R. J. Melatonin or L-tryptophan accelerates healing of gastroduodenal ulcers in patients treated with omeprazole. J.Pineal Res. 2011;50:389-394. View abstract.
  297. Brown, M. A., Quan, S. F., and Eichling, P. S. Circadian rhythm sleep disorder, free-running type in a sighted male with severe depression, anxiety, and agoraphobia. J.Clin.Sleep Med. 2-15-2011;7:93-94. View abstract.
  298. Ozcengiz, D., Gunes, Y., and Ozmete, O. Oral melatonin, dexmedetomidine, and midazolam for prevention of postoperative agitation in children. J.Anesth. 2011;25:184-188. View abstract.
  299. Hollway, J. A. and Aman, M. G. Pharmacological treatment of sleep disturbance in developmental disabilities: a review of the literature. Res.Dev.Disabil. 2011;32:939-962. View abstract.
  300. Rondanelli, M., Opizzi, A., Monteferrario, F., Antoniello, N., Manni, R., and Klersy, C. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J.Am.Geriatr.Soc. 2011;59:82-90. View abstract.
  301. Gonciarz, M., Gonciarz, Z., Bielanski, W., Mularczyk, A., Konturek, P. C., Brzozowski, T., and Konturek, S. J. The pilot study of 3-month course of melatonin treatment of patients with nonalcoholic steatohepatitis: effect on plasma levels of liver enzymes, lipids and melatonin. J.Physiol Pharmacol. 2010;61:705-710. View abstract.
  302. Hussain, S. A., Al-Khalifa, I. I., Jasim, N. A., and Gorial, F. I. Adjuvant use of melatonin for treatment of fibromyalgia. J.Pineal Res. 2011;50:267-271. View abstract.
  303. Cook, J. S., Sauder, C. L., and Ray, C. A. Melatonin differentially affects vascular blood flow in humans. Am.J.Physiol Heart Circ.Physiol 2011;300:H670-H674. View abstract.
  304. Kozirog, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., and Broncel, M. Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J.Pineal Res. 2011;50:261-266. View abstract.
  305. Abbas, A., Raju, J., Milles, J., and Ramachandran, S. A circadian rhythm sleep disorder: melatonin resets the biological clock. J.R.Coll.Physicians Edinb. 2010;40:311-313. View abstract.
  306. Mozaffari, S., Rahimi, R., and Abdollahi, M. Implications of melatonin therapy in irritable bowel syndrome: a systematic review. Curr.Pharm.Des 2010;16:3646-3655. View abstract.
  307. van Geijlswijk, I. M., Korzilius, H. P., and Smits, M. G. The use of exogenous melatonin in delayed sleep phase disorder: a meta-analysis. Sleep 2010;33:1605-1614. View abstract.
  308. de Almeida, E. A., Di, Mascio P., Harumi, T., Spence, D. W., Moscovitch, A., Hardeland, R., Cardinali, D. P., Brown, G. M., and Pandi-Perumal, S. R. Measurement of melatonin in body fluids: standards, protocols and procedures. Childs Nerv.Syst. 2011;27:879-891. View abstract.
  309. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Jimenez-Sosa, A., Avanzas, P., Bosa-Ojeda, F., and Kaski, J. C. Usefulness of intraplatelet melatonin levels to predict angiographic no-reflow after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Am.J.Cardiol. 12-1-2010;106:1540-1544. View abstract.
  310. Wade, A. G., Crawford, G., Ford, I., McConnachie, A., Nir, T., Laudon, M., and Zisapel, N. Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Curr.Med.Res.Opin. 2011;27:87-98. View abstract.
  311. de, Jonghe A., Korevaar, J. C., van Munster, B. C., and de Rooij, S. E. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int.J.Geriatr.Psychiatry 2010;25:1201-1208. View abstract.
  312. Cichoz-Lach, H., Celinski, K., Konturek, P. C., Konturek, S. J., and Slomka, M. The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. J.Physiol Pharmacol. 2010;61:577-580. View abstract.
  313. Paul, M. A., Gray, G. W., Lieberman, H. R., Love, R. J., Miller, J. C., Trouborst, M., and Arendt, J. Phase advance with separate and combined melatonin and light treatment. Psychopharmacology (Berl) 2011;214:515-523. View abstract.
  314. Uberos, J., Augustin-Morales, M. C., Molina, Carballo A., Florido, J., Narbona, E., and Munoz-Hoyos, A. Normalization of the sleep-wake pattern and melatonin and 6-sulphatoxy-melatonin levels after a therapeutic trial with melatonin in children with severe epilepsy. J.Pineal Res. 2011;50:192-196. View abstract.
  315. Alstadhaug, K. B., Odeh, F., Salvesen, R., and Bekkelund, S. I. Prophylaxis of migraine with melatonin: a randomized controlled trial. Neurology 10-26-2010;75:1527-1532. View abstract.
  316. Vigore, L., Messina, G., Brivio, F., Fumagalli, L., Rovelli, F., DI, Fede G., and Lissoni, P. Psychoneuroendocrine modulation of regulatory T lymphocyte system: in vivo and in vitro effects of the pineal immunomodulating hormone melatonin. In Vivo 2010;24:787-789. View abstract.
  317. Van, Thillo A., Devriendt, K., and Willekens, D. [Sleep disturbances in Smith-Magenis syndrome: treatment with melatonin and beta-adrenergic antagonists]. Tijdschr.Psychiatr. 2010;52:719-723. View abstract.
  318. Kucukakin, B., Klein, M., Lykkesfeldt, J., Reiter, R. J., Rosenberg, J., and Gogenur, I. No effect of melatonin on oxidative stress after laparoscopic cholecystectomy: a randomized placebo-controlled trial. Acta Anaesthesiol.Scand. 2010;54:1121-1127. View abstract.
  319. Al-Aama, T., Brymer, C., Gutmanis, I., Woolmore-Goodwin, S. M., Esbaugh, J., and Dasgupta, M. Melatonin decreases delirium in elderly patients: a randomized, placebo-controlled trial. Int.J.Geriatr.Psychiatry 2011;26:687-694. View abstract.
  320. Cook, J. S. and Ray, C. A. Melatonin attenuates the vestibulosympathetic but not vestibulocollic reflexes in humans: selective impairment of the utricles. J.Appl.Physiol 2010;109:1697-1701. View abstract.
  321. Yousaf, F., Seet, E., Venkatraghavan, L., Abrishami, A., and Chung, F. Efficacy and safety of melatonin as an anxiolytic and analgesic in the perioperative period: a qualitative systematic review of randomized trials. Anesthesiology 2010;113:968-976. View abstract.
  322. Molina-Martinez, F. J., Jimenez-Martinez, M. C., and Vives-Pastor, B. Some questions provoked by a chronic headache (with mixed migraine and cluster headache features) in a woman with a pineal cyst. Answers from a literature review. Cephalalgia 2010;30:1031-1040. View abstract.
  323. Wade, A. G., Ford, I., Crawford, G., McConnachie, A., Nir, T., Laudon, M., and Zisapel, N. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC.Med. 2010;8:51. View abstract.
  324. Rizzo, P., Raffone, E., and Benedetto, V. Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial. Eur.Rev.Med.Pharmacol.Sci. 2010;14:555-561. View abstract.
  325. Mrowicka, M., Garncarek, P., Miller, E., Kedziora, J., Smigielski, J., Malinowska, K., and Mrowicki, J. [Effect of melatonin on activity of superoxide dismutase (CuZn-SOD) in erythrocytes of patients during short- and long-term hypokinesis]. Wiad.Lek. 2010;63:3-9. View abstract.
  326. Strassman, R. J., Qualls, C. R., Lisansky, E. J., and Peake, G. T. Sleep deprivation reduces LH secretion in men independently of melatonin. Acta Endocrinol (Copenh) 1991;124:646-651. View abstract.
  327. Leu, R. M., Beyderman, L., Botzolakis, E. J., Surdyka, K., Wang, L., and Malow, B. A. Relation of melatonin to sleep architecture in children with autism. J.Autism Dev.Disord. 2011;41:427-433. View abstract.
  328. Francis, G. J., Becker, W. J., and Pringsheim, T. M. Acute and preventive pharmacologic treatment of cluster headache. Neurology 8-3-2010;75:463-473. View abstract.
  329. van Geijlswijk, I. M., van der Heijden, K. B., Egberts, A. C., Korzilius, H. P., and Smits, M. G. Dose finding of melatonin for chronic idiopathic childhood sleep onset insomnia: an RCT. Psychopharmacology (Berl) 2010;212:379-391. View abstract.
  330. Chaste, P., Clement, N., Mercati, O., Guillaume, J. L., Delorme, R., Botros, H. G., Pagan, C., Perivier, S., Scheid, I., Nygren, G., Anckarsater, H., Rastam, M., Stahlberg, O., Gillberg, C., Serrano, E., Lemiere, N., Launay, J. M., Mouren-Simeoni, M. C., Leboyer, M., Gillberg, C., Jockers, R., and Bourgeron, T. Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population. PLoS.One. 2010;5:e11495. View abstract.
  331. Kucukakin, B., Wilhelmsen, M., Lykkesfeldt, J., Reiter, R. J., Rosenberg, J., and Gogenur, I. No effect of melatonin to modify surgical-stress response after major vascular surgery: a randomised placebo-controlled trial. Eur.J.Vasc.Endovasc.Surg. 2010;40:461-467. View abstract.
  332. Owens, J. A., Rosen, C. L., Mindell, J. A., and Kirchner, H. L. Use of pharmacotherapy for insomnia in child psychiatry practice: A national survey. Sleep Med. 2010;11:692-700. View abstract.
  333. Zaslavskaia, R. M., Shcherban', E. A., Lilitsa, G. V., and Logvinenko, S. I. [Melatonin in the combined treatment of cardiovascular diseases]. Klin.Med.(Mosk) 2010;88:26-30. View abstract.
  334. Braam, W., van, Geijlswijk, I, Keijzer, H., Smits, M. G., Didden, R., and Curfs, L. M. Loss of response to melatonin treatment is associated with slow melatonin metabolism. J.Intellect.Disabil.Res. 2010;54:547-555. View abstract.
  335. Mazzoccoli, G., Vendemiale, G., De, Cata A., Carughi, S., and Tarquini, R. Altered time structure of neuro-endocrine-immune system function in lung cancer patients. BMC.Cancer 2010;10:314. View abstract.
  336. Baeza, I., Fdez-Tresguerres, J., Ariznavarreta, C., and De la Fuente, M. Effects of growth hormone, melatonin, oestrogens and phytoestrogens on the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio and lipid peroxidation in aged ovariectomized rats. Biogerontology. 2010;11:687-701. View abstract.
  337. Kunz, D. and Mahlberg, R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J.Sleep Res. 2010;19:591-596. View abstract.
  338. Garrido, M., Paredes, S. D., Cubero, J., Lozano, M., Toribio-Delgado, A. F., Munoz, J. L., Reiter, R. J., Barriga, C., and Rodriguez, A. B. Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans. J.Gerontol.A Biol.Sci.Med.Sci. 2010;65:909-914. View abstract.
  339. Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson-Day, B., Allgar, V., Whitton, C., Tomlinson, H., Bennett, S., Jardine, J., McCaffrey, N., Leyland, C., Jakeman, C., and Miles, J. Melatonin versus placebo in children with autism spectrum conditions and severe sleep problems not amenable to behaviour management strategies: a randomised controlled crossover trial. J.Autism Dev.Disord. 2011;41:175-184. View abstract.
  340. Leu-Semenescu, S. and Arnulf, I. [Disruptive nocturnal behavior in elderly subjects: could it be a parasomnia?]. Psychol.Neuropsychiatr.Vieil. 2010;8:97-109. View abstract.
  341. Palm, L., Blennow, G., and Wetterberg, L. Correction of non-24-hour sleep/wake cycle by melatonin in a blind retarded boy. Ann.Neurol. 1991;29:336-339. View abstract.
  342. Rezzani, R., Porteri, E., De, Ciuceis C., Bonomini, F., Rodella, L. F., Paiardi, S., Boari, G. E., Platto, C., Pilu, A., Avanzi, D., Rizzoni, D., and Agabiti, Rosei E. Effects of melatonin and Pycnogenol on small artery structure and function in spontaneously hypertensive rats. Hypertension 2010;55:1373-1380. View abstract.
  343. Jonsson, L., Ljunggren, E., Bremer, A., Pedersen, C., Landen, M., Thuresson, K., Giacobini, M., and Melke, J. Mutation screening of melatonin-related genes in patients with autism spectrum disorders. BMC.Med.Genomics 2010;3:10. View abstract.
  344. Brivio, F., Fumagalli, L., Fumagalli, G., Pescia, S., Brivio, R., DI, Fede G., Rovelli, F., and Lissoni, P. Synchronization of cortisol circadian rhythm by the pineal hormone melatonin in untreatable metastatic solid tumor patients and its possible prognostic significance on tumor progression. In Vivo 2010;24:239-241. View abstract.
  345. Elkhayat, H. A., Hassanein, S. M., Tomoum, H. Y., Abd-Elhamid, I. A., Asaad, T., and Elwakkad, A. S. Melatonin and sleep-related problems in children with intractable epilepsy. Pediatr.Neurol. 2010;42:249-254. View abstract.
  346. Whittom, S., Dumont, M., Petit, D., Desautels, A., Adam, B., Lavigne, G., and Montplaisir, J. Effects of melatonin and bright light administration on motor and sensory symptoms of RLS. Sleep Med. 2010;11:351-355. View abstract.
  347. Miano, S. and Ferri, R. Epidemiology and management of insomnia in children with autistic spectrum disorders. Paediatr.Drugs 4-1-2010;12:75-84. View abstract.
  348. Park, K., Lee, Y., Park, S., Lee, S., Hong, Y., Kil, Lee S., and Hong, Y. Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model. J.Pineal Res. 2010;48:270-281. View abstract.
  349. Espino, J., Bejarano, I., Paredes, S. D., Gonzalez, D., Barriga, C., Reiter, R. J., Pariente, J. A., and Rodriguez, A. B. Melatonin counteracts alterations in oxidative metabolism and cell viability induced by intracellular calcium overload in human leucocytes: changes with age. Basic Clin.Pharmacol.Toxicol. 2010;107:590-597. View abstract.
  350. Cilio, M. R. and Ferriero, D. M. Synergistic neuroprotective therapies with hypothermia. Semin.Fetal Neonatal Med. 2010;15:293-298. View abstract.
  351. Pirodda, A., Raimondi, M. C., and Ferri, G. G. Exploring the reasons why melatonin can improve tinnitus. Med.Hypotheses 2010;75:190-191. View abstract.
  352. Gonzalez, A., Martinez-Campa, C., Mediavilla, M. D., Alonso-Gonzalez, C., Alvarez-Garcia, V., Sanchez-Barcelo, E. J., and Cos, S. Inhibitory effects of melatonin on sulfatase and 17beta-hydroxysteroid dehydrogenase activity and expression in glioma cells. Oncol.Rep. 2010;23:1173-1178. View abstract.
  353. Serfaty, M. A., Osborne, D., Buszewicz, M. J., Blizard, R., and Raven, P. W. A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood. Int.Clin.Psychopharmacol. 2010;25:132-142. View abstract.
  354. Aurora, R. N., Zak, R. S., Maganti, R. K., Auerbach, S. H., Casey, K. R., Chowdhuri, S., Karippot, A., Ramar, K., Kristo, D. A., and Morgenthaler, T. I. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J.Clin.Sleep Med. 2-15-2010;6:85-95. View abstract.
  355. Akmali, M., Ahmadi, R., and Vessal, M. Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. Arch.Iran Med. 2010;13:105-110. View abstract.
  356. Borazan, H., Tuncer, S., Yalcin, N., Erol, A., and Otelcioglu, S. Effects of preoperative oral melatonin medication on postoperative analgesia, sleep quality, and sedation in patients undergoing elective prostatectomy: a randomized clinical trial. J.Anesth. 2010;24:155-160. View abstract.
  357. Pedrosa, A. M., Weinlich, R., Mognol, G. P., Robbs, B. K., Viola, J. P., Campa, A., and Amarante-Mendes, G. P. Melatonin protects CD4+ T cells from activation-induced cell death by blocking NFAT-mediated CD95 ligand upregulation. J.Immunol. 4-1-2010;184:3487-3494. View abstract.
  358. Fang, Q., Chen, G., Zhu, W., Dong, W., and Wang, Z. Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. Mediators.Inflamm. 2009;426346. View abstract.
  359. Zaouali, M. A., Ben, Abdennebi H., Padrissa-Altes, S., Mahfoudh-Boussaid, A., and Rosello-Catafau, J. Pharmacological strategies against cold ischemia reperfusion injury. Expert.Opin.Pharmacother. 2010;11:537-555. View abstract.
  360. Guo, Y., Wang, J., Wang, Z., Yang, Y., Wang, X., and Duan, Q. Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement. J.Huazhong.Univ Sci.Technolog.Med.Sci. 2010;30:1-7. View abstract.
  361. Espino, J., Bejarano, I., Ortiz, A., Lozano, G. M., Garcia, J. F., Pariente, J. A., and Rodriguez, A. B. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa. Fertil.Steril. 2010;94:1915-1917. View abstract.
  362. Srinath, R., Acharya, A. B., and Thakur, S. L. Salivary and gingival crevicular fluid melatonin in periodontal health and disease. J.Periodontol. 2010;81:277-283. View abstract.
  363. Wiktorska, J. A., Lewinski, A., Stuss, M., Nowak, D., Pietras, T., and Sewerynek, E. Effects of certain antioxidants on lipid peroxidation process in lung homogenates of L thyroxine-receiving rats. Neuro.Endocrinol.Lett. 2010;31:137-146. View abstract.
  364. Dilek, M., Naziroglu, M., Baha, Oral H., Suat, Ovey, I, Kucukayaz, M., Mungan, M. T., Kara, H. Y., and Sutcu, R. Melatonin modulates hippocampus NMDA receptors, blood and brain oxidative stress levels in ovariectomized rats. J.Membr.Biol. 2010;233(1-3):135-142. View abstract.
  365. Sharma, S., Haldar, C., Chaube, S. K., Laxmi, T., and Singh, S. S. Long-term melatonin administration attenuates low-LET gamma-radiation-induced lymphatic tissue injury during the reproductively active and inactive phases of Indian palm squirrels (Funambulus pennanti). Br.J.Radiol. 2010;83:137-151. View abstract.
  366. Kaur, C., Sivakumar, V., and Ling, E. A. Melatonin protects periventricular white matter from damage due to hypoxia. J.Pineal Res. 2010;48:185-193. View abstract.
  367. Hoppe, J. B., Frozza, R. L., Horn, A. P., Comiran, R. A., Bernardi, A., Campos, M. M., Battastini, A. M., and Salbego, C. Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation. J.Pineal Res. 2010;48:230-238. View abstract.
  368. Tian, X. Z., Wen, Q., Shi, J. M., Liang, Wang, Zeng, S. M., Tian, J. H., Zhou, G. B., Zhu, S. E., and Liu, G. S. Effects of melatonin on in vitro development of mouse two-cell embryos cultured in HTF medium. Endocr.Res. 2010;35:17-23. View abstract.
  369. Sisecioglu, M., Cankaya, M., Gulcin, I., and Ozdemir, H. Interactions of melatonin and serotonin with lactoperoxidase enzyme. J.Enzyme Inhib.Med.Chem. 2010;25:779-783. View abstract.
  370. Ferrante, E., Rossi, P., Tassorelli, C., Lisotto, C., and Nappi, G. Focus on therapy of primary stabbing headache. J.Headache Pain 2010;11:157-160. View abstract.
  371. Hajak, G., Huether, G., Blanke, J., Blomer, M., Freyer, C., Poeggeler, B., Reimer, A., Rodenbeck, A., Schulz-Varszegi, M., and Ruther, E. The influence of intravenous L-tryptophan on plasma melatonin and sleep in men. Pharmacopsychiatry 1991;24:17-20. View abstract.
  372. Lopez-Munoz, F., Marin, F., and Alamo, C. [The historical background of the pineal gland: II. From the seat of the soul to a neuroendocrine organ]. Rev.Neurol. 1-16-2010;50:117-125. View abstract.
  373. Uluocak, N., Atilgan, D., Erdemir, F., Parlaktas, B. S., Yasar, A., Erkorkmaz, U., and Akbas, A. An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis. Int.Urol.Nephrol. 2010;42:889-895. View abstract.
  374. Neri, G., De, Stefano A., Baffa, C., Kulamarva, G., Di, Giovanni P., Petrucci, G., Poliandri, A., Dispenza, F., Citraro, L., and Croce, A. Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study. Acta Otorhinolaryngol.Ital. 2009;29:86-91. View abstract.
  375. Garcia, J. J., Pinol-Ripoll, G., Martinez-Ballarin, E., Fuentes-Broto, L., Miana-Mena, F. J., Venegas, C., Caballero, B., Escames, G., Coto-Montes, A., and Acuna-Castroviejo, D. Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice. Neurobiol.Aging 2011;32:2045-2054. View abstract.
  376. Kandil, T. S., Mousa, A. A., El-Gendy, A. A., and Abbas, A. M. The potential therapeutic effect of melatonin in Gastro-Esophageal Reflux Disease. BMC.Gastroenterol. 2010;10:7. View abstract.
  377. Esteban, S., Garau, C., Aparicio, S., Moranta, D., Barcelo, P., Fiol, M. A., and Rial, R. Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain. J.Pineal Res. 2010;48:170-177. View abstract.
  378. Das, A., McDowell, M., Pava, M. J., Smith, J. A., Reiter, R. J., Woodward, J. J., Varma, A. K., Ray, S. K., and Banik, N. L. The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors. J.Pineal Res. 2010;48:157-169. View abstract.
  379. Azpeleta, C., Martinez-Alvarez, R. M., Delgado, M. J., Isorna, E., and De, Pedro N. Melatonin reduces locomotor activity and circulating cortisol in goldfish. Horm.Behav. 2010;57:323-329. View abstract.
  380. Mogulkoc, R. and Baltaci, A. K. Effect of melatonin supplementation on plasma vasopressin response to different conditions in rats with hyperthyroidism induced by L-thyroxine. Regul.Pept. 4-9-2010;161(1-3):38-42. View abstract.
  381. Huang, S. H., Cao, X. J., Liu, W., Shi, X. Y., and Wei, W. Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice. J.Pineal Res. 2010;48:109-116. View abstract.
  382. Suwanjang, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B. The protective effect of melatonin on methamphetamine-induced calpain-dependent death pathway in human neuroblastoma SH-SY5Y cultured cells. J.Pineal Res. 2010;48:94-101. View abstract.
  383. Rodella, L. F., Filippini, F., Bonomini, F., Bresciani, R., Reiter, R. J., and Rezzani, R. Beneficial effects of melatonin on nicotine-induced vasculopathy. J.Pineal Res. 2010;48:126-132. View abstract.
  384. Hill, S. M., Frasch, T., Xiang, S., Yuan, L., Duplessis, T., and Mao, L. Molecular mechanisms of melatonin anticancer effects. Integr.Cancer Ther. 2009;8:337-346. View abstract.
  385. Rahman, S. A., Kayumov, L., and Shapiro, C. M. Antidepressant action of melatonin in the treatment of Delayed Sleep Phase Syndrome. Sleep Med. 2010;11:131-136. View abstract.
  386. Paulis, L., Pechanova, O., Zicha, J., Barta, A., Gardlik, R., Celec, P., Kunes, J., and Simko, F. Melatonin interactions with blood pressure and vascular function during L-NAME-induced hypertension. J.Pineal Res. 2010;48:102-108. View abstract.
  387. Dong, W., Huang, F., Fan, W., Cheng, S., Chen, Y., Zhang, W., Shi, H., and He, H. Differential effects of melatonin on amyloid-beta peptide 25-35-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture. J.Pineal Res. 2010;48:117-125. View abstract.
  388. Nishimura, J., Saegusa, Y., Dewa, Y., Jin, M., Kawai, M., Kemmochi, S., Harada, T., Hayashi, S. M., Shibutani, M., and Mitsumori, K. Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats. Arch.Toxicol. 2010;84:143-153. View abstract.
  389. Bendz, L. M. and Scates, A. C. Melatonin treatment for insomnia in pediatric patients with attention-deficit/hyperactivity disorder. Ann.Pharmacother. 2010;44:185-191. View abstract.
  390. Srivastava, R. K. and Krishna, A. Melatonin modulates glucose homeostasis during winter dormancy in a vespertilionid bat, Scotophilus heathi. Comp Biochem.Physiol A Mol.Integr.Physiol 2010;155:392-400. View abstract.
  391. de Castro-Silva, C., de Bruin, V. M., Cunha, G. M., Nunes, D. M., Medeiros, C. A., and de Bruin, P. F. Melatonin improves sleep and reduces nitrite in the exhaled breath condensate in cystic fibrosis--a randomized, double-blind placebo-controlled study. J.Pineal Res. 2010;48:65-71. View abstract.
  392. Song, Y. M. and Chen, M. D. Effects of melatonin administration on plasma leptin concentration and adipose tissue leptin secretion in mice. Acta Biol.Hung. 2009;60:399-407. View abstract.
  393. Paul, M. A., Miller, J. C., Gray, G. W., Love, R. J., Lieberman, H. R., and Arendt, J. Melatonin treatment for eastward and westward travel preparation. Psychopharmacology (Berl) 2010;208:377-386. View abstract.
  394. Di Bella, G. and Colori, B. Complete objective response of neuroblastoma to biological treatment. Neuro.Endocrinol.Lett. 2009;30:437-449. View abstract.
  395. Flemstrom, G., Bengtsson, M. W., Makela, K., and Herzig, K. H. Effects of short-term food deprivation on orexin-A-induced intestinal bicarbonate secretion in comparison with related secretagogues. Acta Physiol (Oxf) 2010;198:373-380. View abstract.
  396. Radwan, P., Skrzydlo-Radomanska, B., Radwan-Kwiatek, K., Burak-Czapiuk, B., and Strzemecka, J. Is melatonin involved in the irritable bowel syndrome? J.Physiol Pharmacol. 2009;60 Suppl 3:67-70. View abstract.
  397. Wirojanan, J., Jacquemont, S., Diaz, R., Bacalman, S., Anders, T. F., Hagerman, R. J., and Goodlin-Jones, B. L. The efficacy of melatonin for sleep problems in children with autism, fragile X syndrome, or autism and fragile X syndrome. J.Clin.Sleep Med. 4-15-2009;5:145-150. View abstract.
  398. Maldonado, M. D., Mora-Santos, M., Naji, L., Carrascosa-Salmoral, M. P., Naranjo, M. C., and Calvo, J. R. Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation. Pharmacol.Res. 2010;62:282-287. View abstract.
  399. Sadowska-Woda, I., Wojcik, N., Karowicz-Bilinska, A., and Bieszczad-Bedrejczuk, E. Effect of selected antioxidants in beta-cyfluthrin-induced oxidative stress in human erythrocytes in vitro. Toxicol.In Vitro 2010;24:879-884. View abstract.
  400. Anderson, K. N. and Shneerson, J. M. Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. J.Clin.Sleep Med. 6-15-2009;5:235-239. View abstract.
  401. Hamada, F., Watanabe, K., Wakatsuki, A., Nagai, R., Shinohara, K., Hayashi, Y., Imamura, R., and Fukaya, T. Therapeutic effects of maternal melatonin administration on ischemia/reperfusion-induced oxidative cerebral damage in neonatal rats. Neonatology. 2010;98:33-40. View abstract.
  402. Chowdhury, V. S., Yamamoto, K., Ubuka, T., Bentley, G. E., Hattori, A., and Tsutsui, K. Melatonin stimulates the release of gonadotropin-inhibitory hormone by the avian hypothalamus. Endocrinology 2010;151:271-280. View abstract.
  403. Liu, Y., Zhang, H., Zhang, L., Zhang, X., Xie, Y., and Zhao, W. Melatonin modulates acute testicular damage induced by carbon ions in mice. Pharmazie 2009;64:685-689. View abstract.
  404. Cernysiov, V., Gerasimcik, N., Mauricas, M., and Girkontaite, I. Regulation of T-cell-independent and T-cell-dependent antibody production by circadian rhythm and melatonin. Int.Immunol. 2010;22:25-34. View abstract.
  405. Murawska-Cialowicz, E., Jethon, Z., Magdalan, J., Januszewska, L., Podhorska-Okolow, M., Zawadzki, M., Sozanski, T., and Dziegiel, P. Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene. Exp.Toxicol.Pathol. 2011;63(1-2):97-103. View abstract.
  406. Yang, F. L., Subeq, Y. M., Lee, C. J., Lee, R. P., Peng, T. C., and Hsu, B. G. Melatonin ameliorates hemorrhagic shock-induced organ damage in rats. J.Surg.Res. 5-15-2011;167:e315-e321. View abstract.
  407. Malekinejad, H., Farshid, A. A., and Mirzakhani, N. Liquorice plant extract reduces ochratoxin A-induced nephrotoxicity in rats. Exp.Toxicol.Pathol. 2011;63(1-2):125-130. View abstract.
  408. Mulder, E. J., Anderson, G. M., Kemperman, R. F., Oosterloo-Duinkerken, A., Minderaa, R. B., and Kema, I. P. Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals. Neuropsychobiology 2010;61:27-32. View abstract.
  409. Gagne, A. M., Danilenko, K. V., Rosolen, S. G., and Hebert, M. Impact of oral melatonin on the electroretinogram cone response. J.Circadian.Rhythms 2009;7:14. View abstract.
  410. Casao, A., Mendoza, N., Perez-Pe, R., Grasa, P., Abecia, J. A., Forcada, F., Cebrian-Perez, J. A., and Muino-Blanco, T. Melatonin prevents capacitation and apoptotic-like changes of ram spermatozoa and increases fertility rate. J.Pineal Res. 2010;48:39-46. View abstract.
  411. Venkataraman, P., Selvakumar, K., Krishnamoorthy, G., Muthusami, S., Rameshkumar, R., Prakash, S., and Arunakaran, J. Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats. Neurosci.Res. 2010;66:189-197. View abstract.
  412. Zhou, W., Wang, P., and Tao, L. Effect of melatonin on proliferation of neonatal cord blood mononuclear cells. World J.Pediatr. 2009;5:300-303. View abstract.
  413. Faigl, V., Keresztes, M., Kulcsar, M., Nagy, S., Keresztes, Z., Amiridis, G. S., Solti, L., Huszenicza, G., and Cseh, S. Testicular function and semen characteristics of Awassi rams treated with melatonin out of the breeding season. Acta Vet.Hung. 2009;57:531-540. View abstract.
  414. Srivastava, R. K. and Krishna, A. Melatonin affects steroidogenesis and delayed ovulation during winter in vespertilionid bat, Scotophilus heathi. J.Steroid Biochem.Mol.Biol. 2010;118(1-2):107-116. View abstract.
  415. Braam, W., Didden, R., Maas, A. P., Korzilius, H., Smits, M. G., and Curfs, L. M. Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia. J.Intellect.Disabil.Res. 1-1-2010;54:52-59. View abstract.
  416. Xu, S., Zhou, Z., Zhang, L., Yu, Z., Zhang, W., Wang, Y., Wang, X., Li, M., Chen, Y., Chen, C., He, M., Zhang, G., and Zhong, M. Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons. Brain Res. 1-22-2010;1311:189-196. View abstract.
  417. Yildirim, G., Attar, R., Ozkan, F., Kumbak, B., Ficicioglu, C., and Yesildaglar, N. The effects of letrozole and melatonin on surgically induced endometriosis in a rat model: a preliminary study. Fertil.Steril. 2010;93:1787-1792. View abstract.
  418. Rechcinski, T., Trzos, E., Wierzbowska-Drabik, K., Krzeminska-Pakula, M., and Kurpesa, M. Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability. Hypertens.Res. 2010;33:56-61. View abstract.
  419. Juszczak, M. and Boczek-Leszczyk, E. Hypothalamic gonadotropin-releasing hormone receptor activation stimulates oxytocin release from the rat hypothalamo-neurohypophysial system while melatonin inhibits this process. Brain Res.Bull. 1-15-2010;81:185-190. View abstract.
  420. Myslobodsky, M. The paradox of caffeine-zolpidem interaction: a network analysis. Curr.Drug Targets. 2009;10:1009-1020. View abstract.
  421. Ortega-Gutierrez, S., Lopez-Vicente, M., Lostale, F., Fuentes-Broto, L., Martinez-Ballarin, E., and Garcia, J. J. Protective effect of melatonin against mitomycin C-induced genotoxic damage in peripheral blood of rats. J.Biomed.Biotechnol. 2009;2009:791432. View abstract.
  422. Manda, K. and Reiter, R. J. Melatonin maintains adult hippocampal neurogenesis and cognitive functions after irradiation. Prog.Neurobiol. 1-11-2010;90:60-68. View abstract.
  423. Di, Bella G. and Madarena, M. Complete objective response of oesophageal squamocellular carcinoma to biological treatment. Neuro.Endocrinol.Lett. 2009;30:312-321. View abstract.
  424. Sonmez, M. F., Narin, F., and Balcioglu, E. Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta. Basic Clin.Pharmacol.Toxicol. 2009;105:410-415. View abstract.
  425. Danielczyk, K. and Dziegiel, P. [MT1 melatonin receptors and their role in the oncostatic action of melatonin]. Postepy Hig.Med.Dosw.(Online.) 2009;63:425-434. View abstract.
  426. Franca, E. L., Feliciano, N. D., Silva, K. A., Ferrari, C. K., and Honorio-Franca, A. C. Modulatory role of melatonin on superoxide release by spleen macrophages isolated from alloxan-induced diabetic rats. Bratisl.Lek.Listy 2009;110:517-522. View abstract.
  427. Geihs, M. A., Vargas, M. A., Maciel, F. E., Caldas, S. S., Cruz, B. P., Primel, E. G., Monserrat, J. M., and Nery, L. E. Effect of melatonin in the antioxidant defense system in the locomotor muscles of the estuarine crab Neohelice granulata (Decapoda, Brachyura). Gen.Comp Endocrinol. 3-1-2010;166:72-82. View abstract.
  428. Wang, X. The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS.Neurosci.Ther. 2009;15:345-357. View abstract.
  429. Shieh, J. M., Wu, H. T., Cheng, K. C., and Cheng, J. T. Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells. J.Pineal Res. 2009;47:339-344. View abstract.
  430. Kim, T. H., Jung, J. A., Kim, G. D., Jang, A. H., Ahn, H. J., Park, Y. S., and Park, C. S. Melatonin inhibits the development of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice. J.Pineal Res. 2009;47:324-329. View abstract.
  431. Shi, J. M., Tian, X. Z., Zhou, G. B., Wang, L., Gao, C., Zhu, S. E., Zeng, S. M., Tian, J. H., and Liu, G. S. Melatonin exists in porcine follicular fluid and improves in vitro maturation and parthenogenetic development of porcine oocytes. J.Pineal Res. 2009;47:318-323. View abstract.
  432. Carbajo-Pescador, S., Martin-Renedo, J., Garcia-Palomo, A., Tunon, M. J., Mauriz, J. L., and Gonzalez-Gallego, J. Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells. J.Pineal Res. 2009;47:330-338. View abstract.
  433. Ersoz, N., Guven, A., Cayci, T., Uysal, B., Turk, E., Oztas, E., Akgul, E. O., Korkmaz, A., and Cetiner, S. Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. Ren Fail. 2009;31:704-710. View abstract.
  434. Saxena, G., Bharti, S., Kamat, P. K., Sharma, S., and Nath, C. Melatonin alleviates memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats. Pharmacol.Biochem.Behav. 2010;94:397-403. View abstract.
  435. Cemek, M., Emin, Buyukokuroglu M., Yurumez, Y., Yavuz, Y., Aslan, A., Buyukben, A., and Aymelek, F. Tissue trace and major element levels in organophosphate insecticide fenthion (Lebaycid) toxicity in rats: prophylactic and therapeutic effect of exogenous melatonin. Ecotoxicol.Environ.Saf 2010;73:206-212. View abstract.
  436. Borah, A. and Mohanakumar, K. P. Melatonin inhibits 6-hydroxydopamine production in the brain to protect against experimental parkinsonism in rodents. J.Pineal Res. 2009;47:293-300. View abstract.
  437. Izykowska, I., Cegielski, M., Gebarowska, E., Podhorska-Okolow, M., Piotrowska, A., Zabel, M., and Dziegiel, P. Effect of melatonin on human keratinocytes and fibroblasts subjected to UVA and UVB radiation In vitro. In Vivo 2009;23:739-745. View abstract.
  438. Izykowska, I., Gebarowska, E., Cegielski, M., Podhorska-Okolow, M., Piotrowska, A., Zabel, M., and Dziegiel, P. Effect of melatonin on melanoma cells subjected to UVA and UVB radiation in In vitro studies. In Vivo 2009;23:733-738. View abstract.
  439. Jagota, A. and Kalyani, D. Effect of melatonin on age induced changes in daily serotonin rhythms in suprachiasmatic nucleus of male Wistar rat. Biogerontology. 2010;11:299-308. View abstract.
  440. Spuch, C., Antequera, D., Isabel Fernandez-Bachiller, M., Isabel Rodriguez-Franco, M., and Carro, E. A new tacrine-melatonin hybrid reduces amyloid burden and behavioral deficits in a mouse model of Alzheimer's disease. Neurotox.Res. 2010;17:421-431. View abstract.
  441. Martinez-Campa, C., Gonzalez, A., Mediavilla, M. D., Alonso-Gonzalez, C., Alvarez-Garcia, V., Sanchez-Barcelo, E. J., and Cos, S. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. Br.J.Cancer 11-3-2009;101:1613-1619. View abstract.
  442. Olivier, P., Fontaine, R. H., Loron, G., Van, Steenwinckel J., Biran, V., Massonneau, V., Kaindl, A., Dalous, J., Charriaut-Marlangue, C., Aigrot, M. S., Pansiot, J., Verney, C., Gressens, P., and Baud, O. Melatonin promotes oligodendroglial maturation of injured white matter in neonatal rats. PLoS.One. 2009;4:e7128. View abstract.
  443. Badoe, E. V. Classical Rett Syndrome in a Ghanaian child: a case report. West Afr.J.Med. 2009;28:134-136. View abstract.
  444. Becker, P. M. and Sattar, M. Treatment of sleep dysfunction and psychiatric disorders. Curr.Treat.Options.Neurol. 2009;11:349-357. View abstract.
  445. Nierenberg, A. A. Low-dose buspirone, melatonin and low-dose bupropion added to mood stabilizers for severe treatment-resistant bipolar depression. Psychother.Psychosom. 2009;78:391-393. View abstract.
  446. Yurtcu, M., Abasiyanik, A., Bicer, S., and Avunduk, M. C. Efficacy of antioxidant treatment in the prevention of testicular atrophy in experimental testicular torsion. J.Pediatr.Surg. 2009;44:1754-1758. View abstract.
  447. Kuehn, C. C., Rodrigues Oliveira, L. G., Santos, C. D., Ferreira, D. S., Alonso Toldo, M. P., de, Albuquerque S., and do Prado, J. C. J. Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection? J.Pineal Res. 2009;47:253-259. View abstract.
  448. Radogna, F., Nuccitelli, S., Mengoni, F., and Ghibelli, L. Neuroprotection by melatonin on astrocytoma cell death. Ann.N.Y.Acad.Sci. 2009;1171:509-513. View abstract.
  449. Paternoster, L., Radogna, F., Accorsi, A., Cristina, Albertini M., Gualandi, G., and Ghibelli, L. Melatonin as a modulator of apoptosis in B-lymphoma cells. Ann.N.Y.Acad.Sci. 2009;1171:345-349. View abstract.
  450. Santello, F. H., Del Vecchio, Filipin M., Caetano, L. C., Brazao, V., Caetano, L. N., Dos Santos, C. D., Alonso Toldo, M. P., and do Prado, J. C. J. Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi. J.Pineal Res. 2009;47:271-276. View abstract.
  451. Kumar, A. and Singh, A. Possible involvement of GABAergic mechanism in protective effect of melatonin against sleep deprivation-induced behaviour modification and oxidative damage in mice. Fundam.Clin.Pharmacol. 2009;23:439-448. View abstract.
  452. Lin, G. J., Huang, S. H., Chen, Y. W., Hueng, D. Y., Chien, M. W., Chia, W. T., Chang, D. M., and Sytwu, H. K. Melatonin prolongs islet graft survival in diabetic NOD mice. J.Pineal Res. 2009;47:284-292. View abstract.
  453. Agrawal, R., Tyagi, E., Shukla, R., and Nath, C. A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia. Neuropharmacology 2009;56:779-787. View abstract.
  454. Daglioglu, E., Serdar, Dike M., Kilinc, K., Erdogan, D., Take, G., Ergungor, F., Okay, O., and Biyikli, Z. Neuroprotective effect of melatonin on experimental peripheral nerve injury: an electron microscopic and biochemical study. Cent.Eur.Neurosurg. 2009;70:109-114. View abstract.
  455. Pan, L., Fu, J. H., Xue, X. D., Xu, W., Zhou, P., and Wei, B. Melatonin protects against oxidative damage in a neonatal rat model of bronchopulmonary dysplasia. World J.Pediatr. 2009;5:216-221. View abstract.
  456. Billiard, M. REM sleep behavior disorder and narcolepsy. CNS.Neurol.Disord.Drug Targets. 2009;8:264-270. View abstract.
  457. Hutton, L. C., Abbass, M., Dickinson, H., Ireland, Z., and Walker, D. W. Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus). Dev.Neurosci. 2009;31:437-451. View abstract.
  458. Petrosillo, G., Colantuono, G., Moro, N., Ruggiero, F. M., Tiravanti, E., Di, Venosa N., Fiore, T., and Paradies, G. Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Am.J.Physiol Heart Circ.Physiol 2009;297:H1487-H1493. View abstract.
  459. Odaci, E. and Kaplan, S. Chapter 16: Melatonin and nerve regeneration. Int.Rev.Neurobiol. 2009;87:317-335. View abstract.
  460. Gomez-Moreno, G., Guardia, J., Ferrera, M. J., Cutando, A., and Reiter, R. J. Melatonin in diseases of the oral cavity. Oral Dis. 2010;16:242-247. View abstract.
  461. McIntyre, I. M., Norman, T. R., Burrows, G. D., and Armstrong, S. M. Melatonin supersensitivity to dim light in seasonal affective disorder. Lancet 2-24-1990;335:488. View abstract.
  462. Tapias, V., Cannon, J. R., and Greenamyre, J. T. Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model. J.Neurosci.Res. 2-1-2010;88:420-427. View abstract.
  463. Sonmez, M. F., Narin, F., Akkus, D., and Ozdamar, S. Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. Toxicol.Ind.Health 2009;25:385-393. View abstract.
  464. Alonso-Vale, M. I., Peres, S. B., Vernochet, C., Farmer, S. R., and Lima, F. B. Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity. J.Pineal Res. 2009;47:221-227. View abstract.
  465. Pan, L., Xu, W., Fu, J. H., and Xue, X. D. [Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2009;11:581-584. View abstract.
  466. Tajes, M., Gutierrez-Cuesta, J., Ortuno-Sahagun, D., Camins, A., and Pallas, M. Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. J.Pineal Res. 2009;47:228-237. View abstract.
  467. Cruz, A., Tasset, I., Ramirez, L. M., Arjona, A., Segura, J., Tunez, I., Montilla, P., Muntane, J., and Padillo, F. J. Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. Rev.Esp.Enferm.Dig. 2009;101:460-463. View abstract.
  468. Reiter, R. J., Paredes, S. D., Manchester, L. C., and Tan, D. X. Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev.Biochem.Mol.Biol. 2009;44:175-200. View abstract.
  469. Zeman, M., Szantoova, K., Stebelova, K., Mravec, B., and Herichova, I. Effect of rhythmic melatonin administration on clock gene expression in the suprachiasmatic nucleus and the heart of hypertensive TGR(mRen2)27 rats. J.Hypertens.Suppl 2009;27:S21-S26. View abstract.
  470. Martin, V., Garcia-Santos, G., Rodriguez-Blanco, J., Casado-Zapico, S., Sanchez-Sanchez, A., Antolin, I., Medina, M., and Rodriguez, C. Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death. Cancer Lett. 1-28-2010;287:216-223. View abstract.
  471. Terron, M. P., Delgado, J., Paredes, S. D., Barriga, C., Reiter, R. J., and Rodriguez, A. B. Effect of melatonin and tryptophan on humoral immunity in young and old ringdoves (Streptopelia risoria). Exp.Gerontol. 2009;44:653-658. View abstract.
  472. Zarazaga, L. A., Gatica, M. C., Celi, I., Guzman, J. L., and Malpaux, B. Effect of melatonin implants on sexual activity in Mediterranean goat females without separation from males. Theriogenology 10-15-2009;72:910-918. View abstract.
  473. Jung, K. H., Hong, S. W., Zheng, H. M., Lee, D. H., and Hong, S. S. Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model. J.Pineal Res. 2009;47:173-183. View abstract.
  474. Samantaray, S., Das, A., Thakore, N. P., Matzelle, D. D., Reiter, R. J., Ray, S. K., and Banik, N. L. Therapeutic potential of melatonin in traumatic central nervous system injury. J.Pineal Res. 2009;47:134-142. View abstract.
  475. Veneroso, C., Tunon, M. J., Gonzalez-Gallego, J., and Collado, P. S. Melatonin reduces cardiac inflammatory injury induced by acute exercise. J.Pineal Res. 2009;47:184-191. View abstract.
  476. Chang, H. M., Wu, U. I., and Lan, C. T. Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. J.Pineal Res. 2009;47:211-220. View abstract.
  477. Ashrafi, M. R., Mohammadi, M., Tafarroji, J., Shabanian, R., Salamati, P., and Zamani, G. R. Melatonin versus chloral hydrate for recording sleep EEG. Eur.J.Paediatr.Neurol. 2010;14:235-238. View abstract.
  478. Maciel, F. E., Ramos, B. P., Geihs, M. A., Vargas, M. A., Cruz, B. P., Meyer-Rochow, V. B., Vakkuri, O., Allodi, S., Monserrat, J. M., and Nery, L. E. Effects of melatonin in connection with the antioxidant defense system in the gills of the estuarine crab Neohelice granulata. Gen.Comp Endocrinol. 1-15-2010;165:229-236. View abstract.
  479. Stepien, A., Moskwa-Fortuna, A., Wisniewska-Jarosinska, M., Harasiuk, A., and Chojnacki, J. [Melatonin secretion and metabolism in patients with irritable bowel syndrome]. Pol.Merkur Lekarski. 2009;26:440-443. View abstract.
  480. Klupinska, G., Poplawski, T., Smigielski, J., Blasiak, J., and Chojnacki, J. [The effect of melatonin on oxidative DNA damage in gastric mucosa cells of patients with functional dyspepsia]. Pol.Merkur Lekarski. 2009;26:366-369. View abstract.
  481. Bazwinsky-Wutschke, I., Muhlbauer, E., Wolgast, S., and Peschke, E. Transcripts of calcium/calmodulin-dependent kinases are changed after forskolin- or IBMX-induced insulin secretion due to melatonin treatment of rat insulinoma beta-cells (INS-1). Horm.Metab Res. 2009;41:805-813. View abstract.
  482. Simon Padilla, O. J., De Linares Del, Rio C., Godden, P., Granizo, E., Pinilla, M., and Rodriguez, C. [Use of combined treatment with melatonin and clomethiazole in circadian rhythm sleep disorder in the elderly with dementia]. Rev.Esp.Geriatr.Gerontol. 2009;44:233-234. View abstract.
  483. Fukai, S. and Akishita, M. [Hormone replacement therapy--growth hormone, melatonin, DHEA and sex hormones]. Nihon Rinsho 2009;67:1396-1401. View abstract.
  484. Paredes, S. D., Bejarano, I., Terron, M. P., Barriga, C., Reiter, R. J., and Rodriguez, A. B. Melatonin and tryptophan counteract lipid peroxidation and modulate superoxide dismutase activity in ringdove heterophils in vivo. Effect of antigen-induced activation and age. Age (Dordr.) 2009;31:179-188. View abstract.
  485. Neri, G., Baffa, C., De, Stefano A., Poliandri, A., Kulamarva, G., Di, Giovanni P., Petrucci, A. G., Castriotta, A., Citraro, L., Cerrone, D., D' Orazio, F., and Croce, A. Management of tinnitus: oral treatment with melatonin and sulodexide. J.Biol.Regul.Homeost.Agents 2009;23:103-110. View abstract.
  486. Luthringer, R., Muzet, M., Zisapel, N., and Staner, L. The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia. Int.Clin.Psychopharmacol. 2009;24:239-249. View abstract.
  487. Tsiligianni, T., Valasi, I., Cseh, S., Vainas, E., Faigl, V., Samartzi, F., Papanikolaou, T., Dovolou, E., and Amiridis, G. S. Effects of melatonin treatment on follicular development and oocyte quality in Chios ewes - short communication. Acta Vet.Hung. 2009;57:331-335. View abstract.
  488. Carretero, M., Escames, G., Lopez, L. C., Venegas, C., Dayoub, J. C., Garcia, L., and Acuna-Castroviejo, D. Long-term melatonin administration protects brain mitochondria from aging. J.Pineal Res. 2009;47:192-200. View abstract.
  489. Shang, Y., Xu, S. P., Wu, Y., Jiang, Y. X., Wu, Z. Y., Yuan, S. Y., and Yao, S. L. Melatonin reduces acute lung injury in endotoxemic rats. Chin Med.J.(Engl.) 6-20-2009;122:1388-1393. View abstract.
  490. Jang, S. S., Kim, W. D., and Park, W. Y. Melatonin exerts differential actions on X-ray radiation-induced apoptosis in normal mice splenocytes and Jurkat leukemia cells. J.Pineal Res. 2009;47:147-155. View abstract.
  491. Laughlin, G. A., Loucks, A. B., and Yen, S. S. Marked augmentation of nocturnal melatonin secretion in amenorrheic athletes, but not in cycling athletes: unaltered by opioidergic or dopaminergic blockade. J Clin Endocrinol Metab 1991;73:1321-1326. View abstract.
  492. Park, J. W., Hwang, M. S., Suh, S. I., and Baek, W. K. Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells. J.Pineal Res. 2009;46:415-421. View abstract.
  493. Tahan, V., Atug, O., Akin, H., Eren, F., Tahan, G., Tarcin, O., Uzun, H., Ozdogan, O., Tarcin, O., Imeryuz, N., Ozguner, F., Celikel, C., Avsar, E., and Tozun, N. Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. J.Pineal Res. 2009;46:401-407. View abstract.
  494. Bejarano, I., Redondo, P. C., Espino, J., Rosado, J. A., Paredes, S. D., Barriga, C., Reiter, R. J., Pariente, J. A., and Rodriguez, A. B. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J.Pineal Res. 2009;46:392-400. View abstract.
  495. Berlinguer, F., Leoni, G. G., Succu, S., Spezzigu, A., Madeddu, M., Satta, V., Bebbere, D., Contreras-Solis, I., Gonzalez-Bulnes, A., and Naitana, S. Exogenous melatonin positively influences follicular dynamics, oocyte developmental competence and blastocyst output in a goat model. J.Pineal Res. 2009;46:383-391. View abstract.
  496. Li, Z., Nickkholgh, A., Yi, X., Bruns, H., Gross, M. L., Hoffmann, K., Mohr, E., Zorn, M., Buchler, M. W., and Schemmer, P. Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation. J.Pineal Res. 2009;46:365-372. View abstract.
  497. Ozacmak, V. H., Barut, F., and Ozacmak, H. S. Melatonin provides neuroprotection by reducing oxidative stress and HSP70 expression during chronic cerebral hypoperfusion in ovariectomized rats. J.Pineal Res. 2009;47:156-163. View abstract.
  498. Kain, Z. N., MacLaren, J. E., Herrmann, L., Mayes, L., Rosenbaum, A., Hata, J., and Lerman, J. Preoperative melatonin and its effects on induction and emergence in children undergoing anesthesia and surgery. Anesthesiology 2009;111:44-49. View abstract.
  499. Taylor, F. R. Headache prevention with complementary and alternative medicine. Headache 2009;49:966-968. View abstract.
  500. Velarde, E., Alonso-Gomez, A. L., Azpeleta, C., Isorna, E., and Delgado, M. J. Melatonin attenuates the acetylcholine-induced contraction in isolated intestine of a teleost fish. J.Comp Physiol B 2009;179:951-959. View abstract.
  501. Sheth, D. S., Tajuddin, N. F., and Druse, M. J. Antioxidant neuroprotection against ethanol-induced apoptosis in HN2-5 cells. Brain Res. 8-18-2009;1285:14-21. View abstract.
  502. Olcese, J. M., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., and Arendash, G. W. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J.Pineal Res. 2009;47:82-96. View abstract.
  503. Nah, S. S., Won, H. J., Park, H. J., Ha, E., Chung, J. H., Cho, H. Y., and Baik, H. H. Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21(CIP1)/P27(KIP1) pathways. J.Pineal Res. 2009;47:70-74. View abstract.
  504. Todisco, M. Chronic lymphocytic leukemia: long-lasting remission with combination of cyclophosphamide, somatostatin, bromocriptine, retinoids, melatonin, and ACTH. Cancer Biother.Radiopharm. 2009;24:353-355. View abstract.
  505. Gimenez, F., Stornelli, M. C., Tittarelli, C. M., Savignone, C. A., Dorna, I. V., de la Sota, R. L., and Stornelli, M. A. Suppression of estrus in cats with melatonin implants. Theriogenology 9-1-2009;72:493-499. View abstract.
  506. Magnanou, E., Attia, J., Fons, R., Boeuf, G., and Falcon, J. The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula. PLoS.One. 2009;4:e5904. View abstract.
  507. Joo, S. S. and Yoo, Y. M. Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer. J.Pineal Res. 2009;47:8-14. View abstract.
  508. Ganguly, K. and Swarnakar, S. Induction of matrix metalloproteinase-9 and -3 in nonsteroidal anti-inflammatory drug-induced acute gastric ulcers in mice: regulation by melatonin. J.Pineal Res. 2009;47:43-55. View abstract.
  509. Girgert, R., Hanf, V., Emons, G., and Grundker, C. Membrane-bound melatonin receptor MT1 down-regulates estrogen responsive genes in breast cancer cells. J.Pineal Res. 2009;47:23-31. View abstract.
  510. Arrebola, F. A., Abecia, J. A., Forcada, F., Garcia, A., Martin, R. A., and Mesa, O. Effects of annual rainfall and farm on lamb production after treatment with melatonin implants in Merino sheep: a 4-year study. N.Z.Vet.J. 2009;57:141-145. View abstract.
  511. Cetin, Y., Sagcan, S., Gungor, O., Ozyurtlu, N., and Uslu, B. A. Effects of CIDR-G and melatonin implants, and their combination on the efficacy of oestrus induction and fertility of Kilis goats. Reprod.Domest.Anim 2009;44:659-662. View abstract.
  512. Ozdemir, F., Deniz, O., Kaynar, K., Arslan, M., Kavgaci, H., Yildiz, B., and Aydin, F. The effects of melatonin on human hepatoma (Hep G2) cell line. Bratisl.Lek.Listy 2009;110:276-279. View abstract.
  513. Piasek, A., Bartoszek, A., and Namiesnik, J. [Phytochemicals that counteract the cardiotoxic side effects of cancer chemotherapy]. Postepy Hig.Med.Dosw.(Online.) 2009;63:142-158. View abstract.
  514. Renuka, K. and Joshi, B. N. Melatonin-induced changes in ovarian function in the freshwater fish Channa punctatus (Bloch) held in long days and continuous light. Gen.Comp Endocrinol. 1-1-2010;165:42-46. View abstract.
  515. Hoebert, M., van der Heijden, K. B., van Geijlswijk, I. M., and Smits, M. G. Long-term follow-up of melatonin treatment in children with ADHD and chronic sleep onset insomnia. J.Pineal Res. 2009;47:1-7. View abstract.
  516. Dauchy, R. T., Blask, D. E., Dauchy, E. M., Davidson, L. K., Tirrell, P. C., Greene, M. W., Tirrell, R. P., Hill, C. R., and Sauer, L. A. Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. J.Pineal Res. 2009;47:32-42. View abstract.
  517. Bekyarova, G., Galunska, B., Ivanova, D., and Yankova, T. Effect of melatonin on burn-induced gastric mucosal injury in rats. Burns 2009;35:863-868. View abstract.
  518. Huang, J. Y., Hong, Y. T., and Chuang, J. I. Fibroblast growth factor 9 prevents MPP+-induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro. J.Neurochem. 2009;109:1400-1412. View abstract.
  519. Sood, M. R. Treatment approaches to irritable bowel syndrome. Pediatr.Ann. 2009;38:272-276. View abstract.
  520. Ulas, U. H., Korkmaz, A., Karadas, O., Odabasi, Z., and Reiter, R. J. Sunrise-related headache: case report. Cephalalgia 2010;30:118-122. View abstract.
  521. Koch, B. C., Nagtegaal, J. E., Kerkhof, G. A., and Ter Wee, P. M. Circadian sleep-wake rhythm disturbances in end-stage renal disease. Nat.Rev.Nephrol. 2009;5:407-416. View abstract.
  522. Assayed, M. E. and Abd El-Aty, A. M. Protection of rat chromosomes by melatonin against gamma radiation-induced damage. Mutat.Res. 2009;677(1-2):14-20. View abstract.
  523. Gingerich, S., Wang, X., Lee, P. K., Dhillon, S. S., Chalmers, J. A., Koletar, M. M., and Belsham, D. D. The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons. Neuroscience 9-15-2009;162:1134-1140. View abstract.
  524. Radogna, F., Sestili, P., Martinelli, C., Paolillo, M., Paternoster, L., Albertini, M. C., Accorsi, A., Gualandi, G., and Ghibelli, L. Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism. Toxicol.Appl.Pharmacol. 7-15-2009;238:170-177. View abstract.
  525. Galli-Carminati, G., Deriaz, N., and Bertschy, G. Melatonin in treatment of chronic sleep disorders in adults with autism: a retrospective study. Swiss.Med.Wkly. 5-16-2009;139(19-20):293-296. View abstract.
  526. Reiter, R. J., Tan, D. X., Manchester, L. C., Paredes, S. D., Mayo, J. C., and Sainz, R. M. Melatonin and reproduction revisited. Biol.Reprod. 2009;81:445-456. View abstract.
  527. Jung-Hynes, B. and Ahmad, N. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. FASEB J. 2009;23:2803-2809. View abstract.
  528. Tapias, V., Escames, G., Lopez, L. C., Lopez, A., Camacho, E., Carrion, M. D., Entrena, A., Gallo, M. A., Espinosa, A., and Acuna-Castroviejo, D. Melatonin and its brain metabolite N-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice. J.Neurosci.Res. 2009;87:3002-3010. View abstract.
  529. Kulkarni, S. K. and Dhir, A. Current investigational drugs for major depression. Expert.Opin.Investig.Drugs 2009;18:767-788. View abstract.
  530. Ramirez-Rodriguez, G., Klempin, F., Babu, H., Benitez-King, G., and Kempermann, G. Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. Neuropsychopharmacology 2009;34:2180-2191. View abstract.
  531. Aladag, M. A., Turkoz, Y., Parlakpinar, H., Ozen, H., Egri, M., and Unal, S. C. Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats. Neurochem.Res. 2009;34:1935-1944. View abstract.
  532. Baeza, I., Alvarado, C., Alvarez, P., Salazar, V., Castillo, C., Ariznavarreta, C., Fdez-Tresguerres, J. A., and De la Fuente, M. Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens. J.Reprod.Immunol. 2009;80(1-2):70-79. View abstract.
  533. Kesik, V., Guven, A., Vurucu, S., Tunc, T., Uysal, B., Gundogdu, G., Oztas, E., and Korkmaz, A. Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion. J.Surg.Res. 2009;157:e97-e105. View abstract.
  534. Rai, S., Haldar, C., and Singh, R. Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine. Immun.Ageing 2009;6:5. View abstract.
  535. Venkataraman, P., Krishnamoorthy, G., Selvakumar, K., and Arunakaran, J. Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. Basic Clin.Pharmacol.Toxicol. 2009;105:92-97. View abstract.
  536. Wisessmith, W., Phansuwan-Pujito, P., Govitrapong, P., and Chetsawang, B. Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. J.Pineal Res. 2009;46:433-440. View abstract.
  537. Sokullu, O., Sanioglu, S., Kurc, E., Sargin, M., Deniz, H., Tartan, Z., Aka, S. A., and Bilgen, F. Does the circadian rhythm of melatonin affect ischemia-reperfusion injury after coronary artery bypass grafting? Heart Surg.Forum 2009;12:E95-E99. View abstract.
  538. Braam, W., Smits, M. G., Didden, R., Korzilius, H., van Geijlswijk, I. M., and Curfs, L. M. Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Dev.Med.Child Neurol. 2009;51:340-349. View abstract.
  539. Guo, J. F. and Yao, B. Z. [Serum melatonin levels in children with epilepsy or febrile seizures]. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2009;11:288-290. View abstract.
  540. Bekyarova, G., Tancheva, S., and Hristova, M. Protective effect of melatonin against oxidative hepatic injury after experimental thermal trauma. Methods Find.Exp.Clin.Pharmacol. 2009;31:11-14. View abstract.
  541. Limousin, N., Dehais, C., Gout, O., Heran, F., Oudiette, D., and Arnulf, I. A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder). Sleep Med. 2009;10:1059-1062. View abstract.
  542. Makay, B., Makay, O., Yenisey, C., Icoz, G., Ozgen, G., Unsal, E., Akyildiz, M., and Yetkin, E. The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link? Mediators.Inflamm. 2009;2009:391682. View abstract.
  543. Benitez-King, G., Soto-Vega, E., and Ramirez-Rodriguez, G. Melatonin modulates microfilament phenotypes in epithelial cells: implications for adhesion and inhibition of cancer cell migration. Histol.Histopathol. 2009;24:789-799. View abstract.
  544. Kurcer, Z., Hekimoglu, A., Aral, F., Baba, F., and Sahna, E. Effect of melatonin on epididymal sperm quality after testicular ischemia/reperfusion in rats. Fertil.Steril. 3-15-2010;93:1545-1549. View abstract.
  545. Ritzenthaler, T., Nighoghossian, N., Berthiller, J., Schott, A. M., Cho, T. H., Derex, L., Brun, J., Trouillas, P., and Claustrat, B. Nocturnal urine melatonin and 6-sulphatoxymelatonin excretion at the acute stage of ischaemic stroke. J.Pineal Res. 2009;46:349-352. View abstract.
  546. Kedziora-Kornatowska, K., Szewczyk-Golec, K., Kozakiewicz, M., Pawluk, H., Czuczejko, J., Kornatowski, T., Bartosz, G., and Kedziora, J. Melatonin improves oxidative stress parameters measured in the blood of elderly type 2 diabetic patients. J.Pineal Res. 2009;46:333-337. View abstract.
  547. Gogenur, I., Kucukakin, B., Bisgaard, T., Kristiansen, V., Hjortso, N. C., Skene, D. J., and Rosenberg, J. The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. Anesth.Analg. 2009;108:1152-1156. View abstract.
  548. Ismail, S. A. and Mowafi, H. A. Melatonin provides anxiolysis, enhances analgesia, decreases intraocular pressure, and promotes better operating conditions during cataract surgery under topical anesthesia. Anesth.Analg. 2009;108:1146-1151. View abstract.
  549. Wang, X., Figueroa, B. E., Stavrovskaya, I. G., Zhang, Y., Sirianni, A. C., Zhu, S., Day, A. L., Kristal, B. S., and Friedlander, R. M. Methazolamide and melatonin inhibit mitochondrial cytochrome C release and are neuroprotective in experimental models of ischemic injury. Stroke 2009;40:1877-1885. View abstract.
  550. Vazquez, M. I., Forcada, F., Casao, A., Abecia, J. A., Sosa, C., and Palacin, I. Undernutrition and exogenous melatonin can affect the in vitro developmental competence of ovine oocytes on a seasonal basis. Reprod.Domest.Anim 2010;45:677-684. View abstract.
  551. Golnik, A. E. and Ireland, M. Complementary alternative medicine for children with autism: a physician survey. J.Autism Dev.Disord. 2009;39:996-1005. View abstract.
  552. Potter, M., Moses, A., and Wozniak, J. Alternative treatments in pediatric bipolar disorder. Child Adolesc.Psychiatr.Clin.N.Am. 2009;18:483-514, xi. View abstract.
  553. Kaji, H., Inukai, Y., Maiguma, T., Ono, H., Teshima, D., Hiramoto, K., and Makino, K. Radical scavenging activity of bisbenzylisoquinoline alkaloids and traditional prophylactics against chemotherapy-induced oral mucositis. J.Clin.Pharm.Ther. 2009;34:197-205. View abstract.
  554. Detanico, B. C., Piato, A. L., Freitas, J. J., Lhullier, F. L., Hidalgo, M. P., Caumo, W., and Elisabetsky, E. Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur.J.Pharmacol. 4-1-2009;607(1-3):121-125. View abstract.
  555. Garzon, C., Guerrero, J. M., Aramburu, O., and Guzman, T. Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study. Aging Clin.Exp.Res. 2009;21:38-42. View abstract.
  556. Ambriz-Tututi, M., Rocha-Gonzalez, H. I., Cruz, S. L., and Granados-Soto, V. Melatonin: a hormone that modulates pain. Life Sci. 4-10-2009;84(15-16):489-498. View abstract.
  557. Maity, P., Bindu, S., Dey, S., Goyal, M., Alam, A., Pal, C., Reiter, R., and Bandyopadhyay, U. Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. J.Pineal Res. 2009;46:314-323. View abstract.
  558. Tamura, E. K., Cecon, E., Monteiro, A. W., Silva, C. L., and Markus, R. P. Melatonin inhibits LPS-induced NO production in rat endothelial cells. J.Pineal Res. 2009;46:268-274. View abstract.
  559. Ersahin, M., Toklu, H. Z., Cetinel, S., Yuksel, M., Yegen, B. C., and Sener, G. Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms. J.Pineal Res. 2009;46:324-332. View abstract.
  560. Paredes, S. D., Marchena, A. M., Bejarano, I., Espino, J., Barriga, C., Rial, R. V., Reiter, R. J., and Rodriguez, A. B. Melatonin and tryptophan affect the activity-rest rhythm, core and peripheral temperatures, and interleukin levels in the ringdove: changes with age. J.Gerontol.A Biol.Sci.Med.Sci. 2009;64:340-350. View abstract.
  561. Tajes, Orduna M., Pelegri, Gabalda C., Vilaplana, Hortensi J., Pallas, Lliberia M., and Camins, Espuny A. An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis. J.Pineal Res. 2009;46:262-267. View abstract.
  562. Regodon, S., del Prado, Miguez M., Jardin, I., Lopez, J. J., Ramos, A., Paredes, S. D., and Rosado, J. A. Melatonin, as an adjuvant-like agent, enhances platelet responsiveness. J.Pineal Res. 2009;46:275-285. View abstract.
  563. Sung, J. H., Cho, E. H., Kim, M. O., and Koh, P. O. Identification of proteins differentially expressed by melatonin treatment in cerebral ischemic injury--a proteomics approach. J.Pineal Res. 2009;46:300-306. View abstract.
  564. Grant, S. G., Melan, M. A., Latimer, J. J., and Witt-Enderby, P. A. Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert.Rev.Mol.Med. 2009;11:e5. View abstract.
  565. Diez, E. R., Prados, L. V., Carrion, A., Ponce, Z. A., and Miatello, R. M. A novel electrophysiologic effect of melatonin on ischemia/reperfusion-induced arrhythmias in isolated rat hearts. J.Pineal Res. 2009;46:155-160. View abstract.
  566. Cucina, A., Proietti, S., D'Anselmi, F., Coluccia, P., Dinicola, S., Frati, L., and Bizzarri, M. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. J.Pineal Res. 2009;46:172-180. View abstract.
  567. Regodon, S., Ramos, A., Morgado, S., Tarazona, R., Martin-Palomino, P., Rosado, J. A., and Miguez, Mdel P. Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus. Vaccine 3-4-2009;27:1566-1570. View abstract.
  568. Bharti, V. K. and Srivastava, R. S. Fluoride-induced oxidative stress in rat's brain and its amelioration by buffalo (Bubalus bubalis) pineal proteins and melatonin. Biol.Trace Elem.Res. 2009;130:131-140. View abstract.
  569. Gehrman, P. R., Connor, D. J., Martin, J. L., Shochat, T., Corey-Bloom, J., and Ancoli-Israel, S. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am.J.Geriatr.Psychiatry 2009;17:166-169. View abstract.
  570. Maldonado, M. D., Perez-San-Gregorio, M. A., and Reiter, R. J. The role of melatonin in the immuno-neuro-psychology of mental disorders. Recent Pat CNS.Drug Discov. 2009;4:61-69. View abstract.
  571. Takasaki, A., Tamura, H., Taniguchi, K., Asada, H., Taketani, T., Matsuoka, A., Yamagata, Y., Shimamura, K., Morioka, H., and Sugino, N. Luteal blood flow and luteal function. J.Ovarian.Res. 2009;2:1. View abstract.
  572. Chen, Z., Chua, C. C., Gao, J., Chua, K. W., Ho, Y. S., Hamdy, R. C., and Chua, B. H. Prevention of ischemia/reperfusion-induced cardiac apoptosis and injury by melatonin is independent of glutathione peroxdiase 1. J.Pineal Res. 2009;46:235-241. View abstract.
  573. Signorini, C., Ciccoli, L., Leoncini, S., Carloni, S., Perrone, S., Comporti, M., Balduini, W., and Buonocore, G. Free iron, total F-isoprostanes and total F-neuroprostanes in a model of neonatal hypoxic-ischemic encephalopathy: neuroprotective effect of melatonin. J.Pineal Res. 2009;46:148-154. View abstract.
  574. Solmaz, I., Gurkanlar, D., Gokcil, Z., Goksoy, C., Ozkan, M., and Erdogan, E. Antiepileptic activity of melatonin in guinea pigs with pentylenetetrazol-induced seizures. Neurol.Res. 2009;31:989-995. View abstract.
  575. MacFarlane, J. G., Cleghorn, J. M., Brown, G. M., and Streiner, D. L. The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. Biol.Psychiatry 8-15-1991;30:371-376. View abstract.
  576. Caballero, B., Vega-Naredo, I., Sierra, V., Huidobro-Fernandez, C., Soria-Valles, C., De Gonzalo-Calvo, D., Tolivia, D., Pallas, M., Camins, A., Rodriguez-Colunga, M. J., and Coto-Montes, A. Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J.Pineal Res. 2009;46:106-114. View abstract.
  577. Esposito, E., Genovese, T., Caminiti, R., Bramanti, P., Meli, R., and Cuzzocrea, S. Melatonin reduces stress-activated/mitogen-activated protein kinases in spinal cord injury. J.Pineal Res. 2009;46:79-86. View abstract.
  578. Koch, B. C., Nagtegaal, J. E., Hagen, E. C., van der Westerlaken, M. M., Boringa, J. B., Kerkhof, G. A., and Ter Wee, P. M. The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: a randomized, placebo-controlled, cross-over study (EMSCAP study). Br.J.Clin.Pharmacol. 2009;67:68-75. View abstract.
  579. Lahiri, S., Singh, P., Singh, S., Rasheed, N., Palit, G., and Pant, K. K. Melatonin protects against experimental reflux esophagitis. J.Pineal Res. 2009;46:207-213. View abstract.
  580. Pei, M., He, F., Wei, L., and Rawson, A. Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes. J.Pineal Res. 2009;46:181-187. View abstract.
  581. Kongsuphol, P., Mukda, S., Nopparat, C., Villarroel, A., and Govitrapong, P. Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J.Pineal Res. 2009;46:199-206. View abstract.
  582. Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., and Reiter, R. J. Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin. J.Pineal Res. 2009;46:128-139. View abstract.
  583. Huang, L. T., Tiao, M. M., Tain, Y. L., Chen, C. C., and Hsieh, C. S. Melatonin ameliorates bile duct ligation-induced systemic oxidative stress and spatial memory deficits in developing rats. Pediatr.Res. 2009;65:176-180. View abstract.
  584. Cagnacci, A., Elliott, J. A., and Yen, S. S. Amplification of pulsatile LH secretion by exogenous melatonin in women. J Clin Endocrinol Metab 1991;73:210-212. View abstract.
  585. Tanaka, T., Yasui, Y., Tanaka, M., Tanaka, T., Oyama, T., and Rahman, K. M. Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem.Biol.Interact. 1-27-2009;177:128-136. View abstract.
  586. Li, H. L., Kang, Y. M., Yu, L., Xu, H. Y., and Zhao, H. Melatonin reduces blood pressure in rats with stress-induced hypertension via GABAA receptors. Clin.Exp.Pharmacol.Physiol 2009;36:436-440. View abstract.
  587. Caumo, W., Levandovski, R., and Hidalgo, M. P. Preoperative anxiolytic effect of melatonin and clonidine on postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy: a double-blind, randomized, placebo-controlled study. J.Pain 2009;10:100-108. View abstract.
  588. Luchetti, F., Betti, M., Canonico, B., Arcangeletti, M., Ferri, P., Galli, F., and Papa, S. ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. Free Radic.Biol.Med. 2-1-2009;46:339-351. View abstract.
  589. Cai, G., Edelmann, L., Goldsmith, J. E., Cohen, N., Nakamine, A., Reichert, J. G., Hoffman, E. J., Zurawiecki, D. M., Silverman, J. M., Hollander, E., Soorya, L., Anagnostou, E., Betancur, C., and Buxbaum, J. D. Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: efficient identification of known microduplications and identification of a novel microduplication in ASMT. BMC.Med.Genomics 2008;1:50. View abstract.
  590. Rimmele, U., Spillmann, M., Bartschi, C., Wolf, O. T., Weber, C. S., Ehlert, U., and Wirtz, P. H. Melatonin improves memory acquisition under stress independent of stress hormone release. Psychopharmacology (Berl) 2009;202:663-672. View abstract.
  591. Greenlee, H., Hershman, D. L., and Jacobson, J. S. Use of antioxidant supplements during breast cancer treatment: a comprehensive review. Breast Cancer Res.Treat. 2009;115:437-452. View abstract.
  592. Ramadan, T. A., Taha, T. A., Samak, M. A., and Hassan, A. Effectiveness of exposure to longday followed by melatonin treatment on semen characteristics of Damascus male goats during breeding and non-breeding seasons. Theriogenology 2009;71:458-468. View abstract.
  593. Mowafi, H. A. and Ismail, S. A. Melatonin improves tourniquet tolerance and enhances postoperative analgesia in patients receiving intravenous regional anesthesia. Anesth.Analg. 2008;107:1422-1426. View abstract.
  594. Korkmaz, A., Tamura, H., Manchester, L. C., Ogden, G. B., Tan, D. X., and Reiter, R. J. Combination of melatonin and a peroxisome proliferator-activated receptor-gamma agonist induces apoptosis in a breast cancer cell line. J.Pineal Res. 2009;46:115-116. View abstract.
  595. Manda, K., Ueno, M., and Anzai, K. Cranial irradiation-induced inhibition of neurogenesis in hippocampal dentate gyrus of adult mice: attenuation by melatonin pretreatment. J.Pineal Res. 2009;46:71-78. View abstract.
  596. Ma, J., Shaw, V. E., and Mitrofanis, J. Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism.Relat Disord. 2009;15:307-314. View abstract.
  597. Scott, P. R., Sargison, N. D., Macrae, A. I., and Gough, M. R. Melatonin treatment prior to the normal breeding season increases fetal number in United Kingdom sheep flocks. Vet.J. 2009;182:198-202. View abstract.
  598. Kohyama, J. A newly proposed disease condition produced by light exposure during night: asynchronization. Brain Dev. 2009;31:255-273. View abstract.
  599. Lu, W. Z., Song, G. H., Gwee, K. A., and Ho, K. Y. The effects of melatonin on colonic transit time in normal controls and IBS patients. Dig.Dis.Sci. 2009;54:1087-1093. View abstract.
  600. Ashkenazy, T., Einat, H., and Kronfeld-Schor, N. We are in the dark here: induction of depression- and anxiety-like behaviours in the diurnal fat sand rat, by short daylight or melatonin injections. Int.J.Neuropsychopharmacol. 2009;12:83-93. View abstract.
  601. Guizar-Sahagun, G., Rodriguez-Balderas, C. A., Franco-Bourland, R. E., Martinez-Cruz, A., Grijalva, I., Ibarra, A., and Madrazo, I. Lack of neuroprotection with pharmacological pretreatment in a paradigm for anticipated spinal cord lesions. Spinal Cord. 2009;47:156-160. View abstract.
  602. Valero, N., Nery, A., Bonilla, E., Espina, L. M., Chacin-Bonilla, L., Anez, F., Maldonado, M., and Melean, E. Antagonistic effect of luzindole in mice treated with melatonin during the infection with the venezuelan equine encephalomyelitis virus. Neurochem.Res. 2009;34:268-273. View abstract.
  603. Korkmaz, A., Sanchez-Barcelo, E. J., Tan, D. X., and Reiter, R. J. Role of melatonin in the epigenetic regulation of breast cancer. Breast Cancer Res.Treat. 2009;115:13-27. View abstract.
  604. Lee, S., Jadhav, V., Ayer, R. E., Rojas, H., Hyong, A., Lekic, T., Tang, J., and Zhang, J. H. Dual effects of melatonin on oxidative stress after surgical brain injury in rats. J.Pineal Res. 2009;46:43-48. View abstract.
  605. Sarabia, L., Maurer, I., and Bustos-Obregon, E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on mouse sperm DNA. Ecotoxicol.Environ.Saf 2009;72:663-668. View abstract.
  606. Sarabia, L., Maurer, I., and Bustos-Obregon, E. Melatonin prevents damage elicited by the organophosphorous pesticide diazinon on the mouse testis. Ecotoxicol.Environ.Saf 2009;72:938-942. View abstract.
  607. Baykara, B., Tekmen, I., Pekcetin, C., Ulukus, C., Tuncel, P., Sagol, O., Ormen, M., and Ozogul, C. The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver. Acta Histochem. 2009;111:42-51. View abstract.
  608. Braam, W., Didden, R., Smits, M. G., and Curfs, L. M. Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial. J.Child Neurol. 2008;23:649-654. View abstract.
  609. Manjunatha, B. M., Devaraj, M., Gupta, P. S., Ravindra, J. P., and Nandi, S. Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development. Reprod.Domest.Anim 2009;44:12-16. View abstract.
  610. Chetsawang, B., Chetsawang, J., and Govitrapong, P. Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. J.Pineal Res. 2009;46:36-42. View abstract.
  611. Kang, J. T., Koo, O. J., Kwon, D. K., Park, H. J., Jang, G., Kang, S. K., and Lee, B. C. Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells. J.Pineal Res. 2009;46:22-28. View abstract.
  612. Ortiz-Lopez, L., Morales-Mulia, S., Ramirez-Rodriguez, G., and Benitez-King, G. ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration. J.Pineal Res. 2009;46:15-21. View abstract.
  613. Vazquez, M. I., Forcada, F., Casao, A., Sosa, C., Palacin, I., and Abecia, J. A. Effects of melatonin and undernutrition on the viability of ovine embryos during anestrus and the breeding season. Anim Reprod.Sci. 2009;112(1-2):83-94. View abstract.
  614. Liang, R., Nickkholgh, A., Hoffmann, K., Kern, M., Schneider, H., Sobirey, M., Zorn, M., Buchler, M. W., and Schemmer, P. Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation. J.Pineal Res. 2009;46:8-14. View abstract.
  615. Hardeland, R., Poeggeler, B., Srinivasan, V., Trakht, I., Pandi-Perumal, S. R., and Cardinali, D. P. Melatonergic drugs in clinical practice. Arzneimittelforschung. 2008;58:1-10. View abstract.
  616. Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., and Cardinali, D. P. Jet lag: therapeutic use of melatonin and possible application of melatonin analogs. Travel.Med Infect.Dis. 2008;6(1-2):17-28. View abstract.
  617. Anderson, K. N., Jamieson, S., Graham, A. J., and Shneerson, J. M. REM sleep behaviour disorder treated with melatonin in a patient with Alzheimer's disease. Clin.Neurol.Neurosurg. 2008;110:492-495. View abstract.
  618. Wirtz, P. H., Spillmann, M., Bartschi, C., Ehlert, U., and von Kanel, R. Oral melatonin reduces blood coagulation activity: a placebo-controlled study in healthy young men. J Pineal Res 2008;44:127-133. View abstract.
  619. Braam, W., Didden, R., Smits, M., and Curfs, L. Melatonin treatment in individuals with intellectual disability and chronic insomnia: a randomized placebo-controlled study. J Intellect.Disabil.Res 2008;52(Pt 3):256-264. View abstract.
  620. Szczepanik, M. Melatonin and its influence on immune system. J Physiol Pharmacol 2007;58 Suppl 6:115-124. View abstract.
  621. Konturek, S. J., Konturek, P. C., Brzozowski, T., and Bubenik, G. A. Role of melatonin in upper gastrointestinal tract. J Physiol Pharmacol 2007;58 Suppl 6:23-52. View abstract.
  622. Reiter, R. J., Tan, D. X., Manchester, L. C., and Tamura, H. Melatonin defeats neurally-derived free radicals and reduces the associated neuromorphological and neurobehavioral damage. J Physiol Pharmacol 2007;58 Suppl 6:5-22. View abstract.
  623. Andersen, I. M., Kaczmarska, J., McGrew, S. G., and Malow, B. A. Melatonin for insomnia in children with autism spectrum disorders. J.Child Neurol. 2008;23:482-485. View abstract.
  624. Wasdell, M. B., Jan, J. E., Bomben, M. M., Freeman, R. D., Rietveld, W. J., Tai, J., Hamilton, D., and Weiss, M. D. A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. J Pineal Res 2008;44:57-64. View abstract.
  625. Dowling, G. A., Burr, R. L., van Someren, E. J., Hubbard, E. M., Luxenberg, J. S., Mastick, J., and Cooper, B. A. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr.Soc. 2008;56:239-246. View abstract.
  626. Wakabayashi, H., Shimada, K., and Satoh, T. Effects of diazepam administration on melatonin synthesis in the rat pineal gland in vivo. Chem Pharm Bull (Tokyo) 1991;39:2674-2676. View abstract.
  627. Lemoine, P., Nir, T., Laudon, M., and Zisapel, N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res 2007;16:372-380. View abstract.
  628. Caumo, W., Torres, F., Moreira, N. L., Jr., Auzani, J. A., Monteiro, C. A., Londero, G., Ribeiro, D. F., and Hidalgo, M. P. The clinical impact of preoperative melatonin on postoperative outcomes in patients undergoing abdominal hysterectomy. Anesth.Analg. 2007;105:1263-71, table. View abstract.
  629. Toma, C., Rossi, M., Sousa, I., Blasi, F., Bacchelli, E., Alen, R., Vanhala, R., Monaco, A. P., Jarvela, I., and Maestrini, E. Is ASMT a susceptibility gene for autism spectrum disorders? A replication study in European populations. Mol.Psychiatry 2007;12:977-979. View abstract.
  630. Lopez-Gonzalez, M. A., Santiago, A. M., and Esteban-Ortega, F. Sulpiride and melatonin decrease tinnitus perception modulating the auditolimbic dopaminergic pathway. J Otolaryngol. 2007;36:213-219. View abstract.
  631. Tzischinsky, O., Skene, D., Epstein, R., and Lavie, P. Circadian rhythms in 6-sulphatoxymelatonin and nocturnal sleep in blind children. Chronobiol.Int 1991;8:168-175. View abstract.
  632. Peles, E., Hetzroni, T., Bar-Hamburger, R., Adelson, M., and Schreiber, S. Melatonin for perceived sleep disturbances associated with benzodiazepine withdrawal among patients in methadone maintenance treatment: a double-blind randomized clinical trial. Addiction 2007;102:1947-1953. View abstract.
  633. Sugaya, K., Nishijima, S., Miyazato, M., Kadekawa, K., and Ogawa, Y. Effects of melatonin and rilmazafone on nocturia in the elderly. J Int.Med Res 2007;35:685-691. View abstract.
  634. Wade, A. G., Ford, I., Crawford, G., McMahon, A. D., Nir, T., Laudon, M., and Zisapel, N. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr.Med Res Opin. 2007;23:2597-2605. View abstract.
  635. Vissers, F. H., Knipschild, P. G., and Crebolder, H. F. Is melatonin helpful in stopping the long-term use of hypnotics? A discontinuation trial. Pharm.World Sci. 2007;29:641-646. View abstract.
  636. Schmidt, C. M., Knief, A., Deuster, D., Matulat, P., and am Zehnhoff-Dinnesen, A. G. Melatonin is a useful alternative to sedation in children undergoing brainstem audiometry with an age dependent success rate--a field report of 250 investigations. Neuropediatrics 2007;38:2-4. View abstract.
  637. Bjorvatn, B., Stangenes, K., Oyane, N., Forberg, K., Lowden, A., Holsten, F., and Akerstedt, T. Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work. Scand.J Work Environ.Health 2007;33:204-214. View abstract.
  638. Vandewalle, G., Middleton, B., Rajaratnam, S. M., Stone, B. M., Thorleifsdottir, B., Arendt, J., and Dijk, D. J. Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiod. J Sleep Res 2007;16:148-155. View abstract.
  639. Forrest, C. M., Mackay, G. M., Stoy, N., Stone, T. W., and Darlington, L. G. Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin. Br.J Clin Pharmacol 2007;64:517-526. View abstract.
  640. Melke, J., Goubran, Botros H., Chaste, P., Betancur, C., Nygren, G., Anckarsater, H., Rastam, M., Stahlberg, O., Gillberg, I. C., Delorme, R., Chabane, N., Mouren-Simeoni, M. C., Fauchereau, F., Durand, C. M., Chevalier, F., Drouot, X., Collet, C., Launay, J. M., Leboyer, M., Gillberg, C., and Bourgeron, T. Abnormal melatonin synthesis in autism spectrum disorders. Mol.Psychiatry 2008;13:90-98. View abstract.
  641. Lissoni, P. Biochemotherapy with immunomodulating pineal hormones other than melatonin: 5-methoxytryptamine as a new oncostatic pineal agent. Pathol.Biol.(Paris) 2007;55(3-4):198-200. View abstract.
  642. Lissoni, P. Biochemotherapy with standard chemotherapies plus the pineal hormone melatonin in the treatment of advanced solid neoplasms. Pathol.Biol.(Paris) 2007;55(3-4):201-204. View abstract.
  643. Klupinska, G., Poplawski, T., Drzewoski, J., Harasiuk, A., Reiter, R. J., Blasiak, J., and Chojnacki, J. Therapeutic effect of melatonin in patients with functional dyspepsia. J.Clin.Gastroenterol. 2007;41:270-274. View abstract.
  644. Berk, L., Berkey, B., Rich, T., Hrushesky, W., Blask, D., Gallagher, M., Kudrimoti, M., McGarry, R. C., Suh, J., and Mehta, M. Randomized phase II trial of high-dose melatonin and radiation therapy for RPA class 2 patients with brain metastases (RTOG 0119). Int.J Radiat.Oncol.Biol.Phys. 7-1-2007;68:852-857. View abstract.
  645. Medeiros, C. A., Carvalhedo de Bruin, P. F., Lopes, L. A., Magalhaes, M. C., de Lourdes, Seabra M., and de Bruin, V. M. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study. J Neurol. 2007;254:459-464. View abstract.
  646. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat.Rev. 2007;33:407-418. View abstract.
  647. Suresh Kumar, P. N., Andrade, C., Bhakta, S. G., and Singh, N. M. Melatonin in schizophrenic outpatients with insomnia: a double-blind, placebo-controlled study. J Clin Psychiatry 2007;68:237-241. View abstract.
  648. Komarov, F. I., Raikhlin, N. T., Rapoport, S. I., Malinovskaia, N. K., Voznesenskaia, L. A., and Rumiantseva, A. I. [Irritated bowel syndrome: clinicomorphological aspects of treatment with melaxen]. Klin.Med.(Mosk) 2006;84:30-36. View abstract.
  649. van der Heijden, K. B., Smits, M. G., van Someren, E. J., Ridderinkhof, K. R., and Gunning, W. B. Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia. J Am Acad.Child Adolesc.Psychiatry 2007;46:233-241. View abstract.
  650. Ernst, E., Schmidt, K., and Baum, M. Complementary/Alternative therapies for the treatment of breast cancer. A systematic review of randomized clinical trials and a critique of current terminology. Breast J 2006;12:526-530. View abstract.
  651. Jaworek, J. Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity. J Physiol Pharmacol 2006;57 Suppl 5:83-96. View abstract.
  652. Ravindra, T., Lakshmi, N. K., and Ahuja, Y. R. Melatonin in pathogenesis and therapy of cancer. Indian J Med Sci. 2006;60:523-535. View abstract.
  653. Dominguez-Rodriguez, A., Abreu-Gonzalez, P., Garcia-Gonzalez, M. J., Kaski, J. C., Reiter, R. J., and Jimenez-Sosa, A. A unicenter, randomized, double-blind, parallel-group, placebo-controlled study of Melatonin as an Adjunct in patients with acute myocaRdial Infarction undergoing primary Angioplasty The Melatonin Adjunct in the acute myocaRdial Infarction treated with Angioplasty (MARIA) trial: study design and rationale. Contemp.Clin Trials 2007;28:532-539. View abstract.
  654. Todisco, M. Relapse of high-grade non-Hodgkin's lymphoma after autologous stem cell transplantation: a case successfully treated with cyclophosphamide plus somatostatin, bromocriptine, melatonin, retinoids, and ACTH. Am J Ther 2006;13:556-557. View abstract.
  655. Naguib, M., Samarkandi, A. H., Moniem, M. A., Mansour, Eel, Alshaer, A. A., Al Ayyaf, H. A., Fadin, A., and Alharby, S. W. The effects of melatonin premedication on propofol and thiopental induction dose-response curves: a prospective, randomized, double-blind study. Anesth.Analg. 2006;103:1448-1452. View abstract.
  656. Turkistani, A., Abdullah, K. M., Al Shaer, A. A., Mazen, K. F., and Alkatheri, K. Melatonin premedication and the induction dose of propofol. Eur.J Anaesthesiol. 2007;24:399-402. View abstract.
  657. Vriend, J., Sheppard, M. S., and Borer, K. T. Melatonin increases serum growth hormone and insulin-like growth factor I (IGF-I) levels in male Syrian hamsters via hypothalamic neurotransmitters. Growth Dev.Aging 1990;54:165-171. View abstract.
  658. Grossman, E., Laudon, M., Yalcin, R., Zengil, H., Peleg, E., Sharabi, Y., Kamari, Y., Shen-Orr, Z., and Zisapel, N. Melatonin reduces night blood pressure in patients with nocturnal hypertension. Am J Med 2006;119:898-902. View abstract.
  659. Howes, R. A., Halliday, G. M., and Damian, D. L. Effect of topical melatonin on ultraviolet radiation-induced suppression of Mantoux reactions in humans. Photodermatol.Photoimmunol.Photomed. 2006;22:267-269. View abstract.
  660. Ibrahim, M. G., Bellomo, R., Hart, G. K., Norman, T. R., Goldsmith, D., Bates, S., and Egi, M. A double-blind placebo-controlled randomised pilot study of nocturnal melatonin in tracheostomised patients. Crit Care Resusc. 2006;8:187-191. View abstract.
  661. Garstang, J. and Wallis, M. Randomized controlled trial of melatonin for children with autistic spectrum disorders and sleep problems. Child Care Health Dev. 2006;32:585-589. View abstract.
  662. Giannotti, F., Cortesi, F., Cerquiglini, A., and Bernabei, P. An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism. J.Autism Dev.Disord. 2006;36:741-752. View abstract.
  663. Kocher, L., Brun, J., Borson-Chazot, F., Gonnaud, P. M., and Claustrat, B. Increased REM sleep associated with melatonin deficiency after pinealectomy: a case study. Chronobiol.Int. 2006;23:889-901. View abstract.
  664. Pignone, A. M., Rosso, A. D., Fiori, G., Matucci-Cerinic, M., Becucci, A., Tempestini, A., Livi, R., Generini, S., Gramigna, L., Benvenuti, C., Carossino, A. M., Conforti, M. L., and Perfetto, F. Melatonin is a safe and effective treatment for chronic pulmonary and extrapulmonary sarcoidosis. J Pineal Res 2006;41:95-100. View abstract.
  665. Rozen, T. D. Melatonin responsive hemicrania continua. Headache 2006;46:1203-1204. View abstract.
  666. Srinivasan, V., Smits, M., Spence, W., Lowe, A. D., Kayumov, L., Pandi-Perumal, S. R., Parry, B., and Cardinali, D. P. Melatonin in mood disorders. World J Biol.Psychiatry 2006;7:138-151. View abstract.
  667. Weekley, L. B. Melatonin-induced relaxation of rat aorta: interaction with adrenergic agonists. J Pineal Res 1991;11:28-34. View abstract.
  668. Capuzzo, M., Zanardi, B., Schiffino, E., Buccoliero, C., Gragnaniello, D., Bianchi, S., and Alvisi, R. Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery. Anesth.Analg. 2006;103:121-3, table. View abstract.
  669. Sury, M. R. and Fairweather, K. The effect of melatonin on sedation of children undergoing magnetic resonance imaging. Br.J Anaesth. 2006;97:220-225. View abstract.
  670. Wyatt, J. K., Dijk, D. J., Ritz-de Cecco, A., Ronda, J. M., and Czeisler, C. A. Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependent. Sleep 5-1-2006;29:609-618. View abstract.
  671. Gubin, D. G., Gubin, G. D., Waterhouse, J., and Weinert, D. The circadian body temperature rhythm in the elderly: effect of single daily melatonin dosing. Chronobiol.Int. 2006;23:639-658. View abstract.
  672. Miller, S. C., Pandi-Perumal, S. R., Esquifino, A. I., Cardinali, D. P., and Maestroni, G. J. The role of melatonin in immuno-enhancement: potential application in cancer. Int.J Exp Pathol. 2006;87:81-87. View abstract.
  673. Spears, R. C. Hemicrania continua: a case in which a patient experienced complete relief on melatonin. Headache 2006;46:524-527. View abstract.
  674. Peres, M. F., Masruha, M. R., Zukerman, E., Moreira-Filho, C. A., and Cavalheiro, E. A. Potential therapeutic use of melatonin in migraine and other headache disorders. Expert.Opin.Investig.Drugs 2006;15:367-375. View abstract.
  675. Mero, A. A., Vahalummukka, M., Hulmi, J. J., Kallio, P., and von Wright, A. Effects of resistance exercise session after oral ingestion of melatonin on physiological and performance responses of adult men. Eur.J Appl.Physiol 2006;96:729-739. View abstract.
  676. Norsa, A. and Martino, V. Somatostatin, retinoids, melatonin, vitamin D, bromocriptine, and cyclophosphamide in advanced non-small-cell lung cancer patients with low performance status. Cancer Biother.Radiopharm. 2006;21:68-73. View abstract.
  677. Megwalu, U. C., Finnell, J. E., and Piccirillo, J. F. The effects of melatonin on tinnitus and sleep. Otolaryngol.Head Neck Surg. 2006;134:210-213. View abstract.
  678. Jansen, S. L., Forbes, D. A., Duncan, V., and Morgan, D. G. Melatonin for cognitive impairment. Cochrane.Database.Syst.Rev. 2006;:CD003802. View abstract.
  679. Gorfine, T., Assaf, Y., Goshen-Gottstein, Y., Yeshurun, Y., and Zisapel, N. Sleep-anticipating effects of melatonin in the human brain. Neuroimage. 5-15-2006;31:410-418. View abstract.
  680. Yi, C., Pan, X., Yan, H., Guo, M., and Pierpaoli, W. Effects of melatonin in age-related macular degeneration. Ann.N.Y Acad.Sci. 2005;1057:384-392. View abstract.
  681. Cagnacci, A., Elliott, J. A., and Yen, S. S. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol.Metab 1992;75:447-452. View abstract.
  682. Kasimay, O., Cakir, B., Devseren, E., and Yegen, B. C. Exogenous melatonin delays gastric emptying rate in rats: role of CCK2 and 5-HT3 receptors. J Physiol Pharmacol 2005;56:543-553. View abstract.
  683. Cagnacci, A., Cannoletta, M., Renzi, A., Baldassari, F., Arangino, S., and Volpe, A. Prolonged melatonin administration decreases nocturnal blood pressure in women. Am J Hypertens. 2005;18(12 Pt 1):1614-1618. View abstract.
  684. Wang, J. Z. and Wang, Z. F. Role of melatonin in Alzheimer-like neurodegeneration. Acta Pharmacol Sin. 2006;27:41-49. View abstract.
  685. Smith, M. R., Lee, C., Crowley, S. J., Fogg, L. F., and Eastman, C. I. Morning melatonin has limited benefit as a soporific for daytime sleep after night work. Chronobiol.Int. 2005;22:873-888. View abstract.
  686. Mundey, K., Benloucif, S., Harsanyi, K., Dubocovich, M. L., and Zee, P. C. Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Sleep 10-1-2005;28:1271-1278. View abstract.
  687. Dagan, Y. and Ayalon, L. Case study: psychiatric misdiagnosis of non-24-hours sleep-wake schedule disorder resolved by melatonin. J Am Acad.Child Adolesc.Psychiatry 2005;44:1271-1275. View abstract.
  688. Perras, B., Ozcan, S., Fehm, H. L., and Born, J. Melatonin does not inhibit hypothalamic-pituitary-adrenal activity in waking young men. J Neuroendocrinol. 2005;17:811-816. View abstract.
  689. Lu, W. Z., Gwee, K. A., Moochhalla, S., and Ho, K. Y. Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Aliment.Pharmacol Ther 11-15-2005;22:927-934. View abstract.
  690. Revell, V. L., Burgess, H. J., Gazda, C. J., Smith, M. R., Fogg, L. F., and Eastman, C. I. Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. J Clin Endocrinol.Metab 2006;91:54-59. View abstract.
  691. Slominski, A., Fischer, T. W., Zmijewski, M. A., Wortsman, J., Semak, I., Zbytek, B., Slominski, R. M., and Tobin, D. J. On the role of melatonin in skin physiology and pathology. Endocrine. 2005;27:137-148. View abstract.
  692. Mills, E., Wu, P., Seely, D., and Guyatt, G. Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res 2005;39:360-366. View abstract.
  693. Valtonen, M., Niskanen, L., Kangas, A. P., and Koskinen, T. Effect of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjects. Nord.J Psychiatry 2005;59:217-221. View abstract.
  694. Faber, M. S., Jetter, A., and Fuhr, U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97:125-134. View abstract.
  695. Gupta, R. and Hutchins, J. Melatonin: a panacea for desperate parents? (Hype or truth). Arch.Dis.Child 2005;90:986-987. View abstract.
  696. Dowling, G. A., Mastick, J., Colling, E., Carter, J. H., Singer, C. M., and Aminoff, M. J. Melatonin for sleep disturbances in Parkinson's disease. Sleep Med 2005;6:459-466. View abstract.
  697. Green, V. A., Pituch, K. A., Itchon, J., Choi, A., O'Reilly, M., and Sigafoos, J. Internet survey of treatments used by parents of children with autism. Res.Dev.Disabil. 2006;27:70-84. View abstract.
  698. Cavallo, A., Ris, M. D., Succop, P., and Jaskiewicz, J. Melatonin treatment of pediatric residents for adaptation to night shift work. Ambul.Pediatr. 2005;5:172-177. View abstract.
  699. van der Heijden, K. B., Smits, M. G., van Someren, E. J., and Boudewijn, Gunning W. Prediction of melatonin efficacy by pretreatment dim light melatonin onset in children with idiopathic chronic sleep onset insomnia. J Sleep Res 2005;14:187-194. View abstract.
  700. Samarkandi, A., Naguib, M., Riad, W., Thalaj, A., Alotibi, W., Aldammas, F., and Albassam, A. Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. Eur.J.Anaesthesiol. 2005;22:189-196. View abstract.
  701. Wiechmann, A. F. and O'Steen, W. K. Melatonin increases photoreceptor susceptibility to light-induced damage. Invest Ophthalmol Vis Sci 1992;33:1894-1902. View abstract.
  702. Ursing, C., von Bahr, C., Brismar, K., and Rojdmark, S. Influence of cigarette smoking on melatonin levels in man. Eur.J Clin Pharmacol 2005;61:197-201. View abstract.
  703. Polimeni, M. A., Richdale, A. L., and Francis, A. J. A survey of sleep problems in autism, Asperger's disorder and typically developing children. J.Intellect.Disabil.Res. 2005;49(Pt 4):260-268. View abstract.
  704. Sanchez-Barcelo, E. J., Cos, S., Mediavilla, D., Martinez-Campa, C., Gonzalez, A., and Alonso-Gonzalez, C. Melatonin-estrogen interactions in breast cancer. J Pineal Res 2005;38:217-222. View abstract.
  705. Gupta, M., Aneja, S., and Kohli, K. Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial. J.Child Neurol. 2005;20:112-115. View abstract.
  706. Hancock, E., O'Callaghan, F., and Osborne, J. P. Effect of melatonin dosage on sleep disorder in tuberous sclerosis complex. J.Child Neurol. 2005;20:78-80. View abstract.
  707. Hancock, E., O'Callaghan, F., English, J., and Osborne, J. P. Melatonin excretion in normal children and in tuberous sclerosis complex with sleep disorder responsive to melatonin. J Child Neurol. 2005;20:21-25. View abstract.
  708. Miller, A. L. Epidemiology, etiology, and natural treatment of seasonal affective disorder. Altern.Med Rev. 2005;10:5-13. View abstract.
  709. Persson, C., Glimelius, B., Ronnelid, J., and Nygren, P. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. Nutrition 2005;21:170-178. View abstract.
  710. Saracz, J. and Rosdy, B. [Effect of melatonin on intractable epilepsies]. Orv.Hetil. 12-19-2004;145:2583-2587. View abstract.
  711. Danilenko, K. V. and Putilov, A. A. Melatonin treatment of winter depression following total sleep deprivation: waking EEG and mood correlates. Neuropsychopharmacology 2005;30:1345-1352. View abstract.
  712. Wesensten, N. J., Balkin, T. J., Reichardt, R. M., Kautz, M. A., Saviolakis, G. A., and Belenky, G. Daytime sleep and performance following a zolpidem and melatonin cocktail. Sleep 1-1-2005;28:93-103. View abstract.
  713. Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., and Touitou, Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biol.Psychiatry 1-15-2005;57:134-138. View abstract.
  714. Brzezinski, A., Vangel, M. G., Wurtman, R. J., Norrie, G., Zhdanova, I., Ben Shushan, A., and Ford, I. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005;9:41-50. View abstract.
  715. Buscemi, N., Vandermeer, B., Pandya, R., Hooton, N., Tjosvold, L., Hartling, L., Baker, G., Vohra, S., and Klassen, T. Melatonin for treatment of sleep disorders. Evid.Rep.Technol.Assess.(Summ.) 2004;:1-7. View abstract.
  716. Mazzoccoli, G., Giuliani, A., Carughi, S., De Cata, A., Puzzolante, F., La Viola, M., Urbano, N., Perfetto, F., and Tarquini, R. The hypothalamic-pituitary-thyroid axis and melatonin in humans: possible interactions in the control of body temperature. Neuro.Endocrinol.Lett. 2004;25:368-372. View abstract.
  717. Gupta, M., Gupta, Y. K., Agarwal, S., Aneja, S., Kalaivani, M., and Kohli, K. Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsia 2004;45:1636-1639. View abstract.
  718. Jan, J. E., Freeman, R. D., Wasdell, M. B., and Bomben, M. M. 'A child with severe night terrors and sleep-walking responds to melatonin therapy'. Dev.Med.Child Neurol. 2004;46:789. View abstract.
  719. Phillips, L. and Appleton, R. E. Systematic review of melatonin treatment in children with neurodevelopmental disabilities and sleep impairment. Dev.Med Child Neurol. 2004;46:771-775. View abstract.
  720. Pinto, L. R., Jr., Seabra, Mde L., and Tufik, S. Different criteria of sleep latency and the effect of melatonin on sleep consolidation. Sleep 9-15-2004;27:1089-1092. View abstract.
  721. Gupta, M., Gupta, Y. K., Agarwal, S., Aneja, S., and Kohli, K. A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes. Br.J.Clin.Pharmacol. 2004;58:542-547. View abstract.
  722. Rajaratnam, S. M., Middleton, B., Stone, B. M., Arendt, J., and Dijk, D. J. Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humans. J Physiol 11-15-2004;561(Pt 1):339-351. View abstract.
  723. Acil, M., Basgul, E., Celiker, V., Karagoz, A. H., Demir, B., and Aypar, U. Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance. Eur.J.Anaesthesiol. 2004;21:553-557. View abstract.
  724. Campos, F. L., Silva-Junior, F. P., de Bruin, V. M., and de Bruin, P. F. Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study. Am.J.Respir.Crit Care Med. 11-1-2004;170:947-951. View abstract.
  725. Mulchahey, J. J., Goldwater, D. R., and Zemlan, F. P. A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin. Life Sci. 8-27-2004;75:1843-1856. View abstract.
  726. Coppola, G., Iervolino, G., Mastrosimone, M., La Torre, G., Ruiu, F., and Pascotto, A. Melatonin in wake-sleep disorders in children, adolescents and young adults with mental retardation with or without epilepsy: a double-blind, cross-over, placebo-controlled trial. Brain Dev. 2004;26:373-376. View abstract.
  727. Peck, J. S., LeGoff, D. B., Ahmed, I., and Goebert, D. Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study. Am J Geriatr.Psychiatry 2004;12:432-436. View abstract.
  728. Mahlberg, R., Kunz, D., Sutej, I., Kuhl, K. P., and Hellweg, R. Melatonin treatment of day-night rhythm disturbances and sundowning in Alzheimer disease: an open-label pilot study using actigraphy. J.Clin.Psychopharmacol. 2004;24:456-459. View abstract.
  729. Kemp, S., Biswas, R., Neumann, V., and Coughlan, A. The value of melatonin for sleep disorders occurring post-head injury: a pilot RCT. Brain Inj. 2004;18:911-919. View abstract.
  730. Brzezinski, A., Fibich, T., Cohen, M., Schenker, J. G., and Laufer, N. Effects of melatonin on progesterone production by human granulosa lutein cells in culture. Fertil.Steril. 1992;58:526-529. View abstract.
  731. Paul, M. A., Gray, G., MacLellan, M., and Pigeau, R. A. Sleep-inducing pharmaceuticals: a comparison of melatonin, zaleplon, zopiclone, and temazepam. Aviat.Space Environ.Med 2004;75:512-519. View abstract.
  732. Nakagawa, H., Sack, R. L., and Lewy, A. J. Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person. Sleep 1992;15:330-336. View abstract.
  733. Gitto, E., Reiter, R. J., Cordaro, S. P., La Rosa, M., Chiurazzi, P., Trimarchi, G., Gitto, P., Calabro, M. P., and Barberi, I. Oxidative and inflammatory parameters in respiratory distress syndrome of preterm newborns: beneficial effects of melatonin. Am J Perinatol. 2004;21:209-216. View abstract.
  734. Honma, K., Kohsaka, M., Fukuda, N., Morita, N., and Honma, S. Effects of vitamin B12 on plasma melatonin rhythm in humans: increased light sensitivity phase-advances the circadian clock? Experientia 8-15-1992;48:716-720. View abstract.
  735. Paul, M. A., Gray, G., Sardana, T. M., and Pigeau, R. A. Melatonin and zopiclone as facilitators of early circadian sleep in operational air transport crews. Aviat.Space Environ.Med 2004;75:439-443. View abstract.
  736. Gupta, M., Aneja, S., and Kohli, K. Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial. Epilepsy Behav. 2004;5:316-321. View abstract.
  737. Tzischinsky, O., Pal, I., Epstein, R., Dagan, Y., and Lavie, P. The importance of timing in melatonin administration in a blind man. J Pineal Res 1992;12:105-108. View abstract.
  738. Cavallo, A., Daniels, S. R., Dolan, L. M., Khoury, J. C., and Bean, J. A. Blood pressure response to melatonin in type 1 diabetes. Pediatr.Diabetes 2004;5:26-31. View abstract.
  739. Drake, M. J., Mills, I. W., and Noble, J. G. Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement. J Urol. 2004;171:1199-1202. View abstract.
  740. Scheer, F. A., Van Montfrans, G. A., van Someren, E. J., Mairuhu, G., and Buijs, R. M. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 2004;43:192-197. View abstract.
  741. Kunz, D., Mahlberg, R., Muller, C., Tilmann, A., and Bes, F. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. J Clin Endocrinol.Metab 2004;89:128-134. View abstract.
  742. Leger, D., Laudon, M., and Zisapel, N. Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy. Am J Med 1-15-2004;116:91-95. View abstract.
  743. Paul, M. A., Gray, G., Kenny, G., and Pigeau, R. A. Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. Aviat.Space Environ.Med 2003;74:1263-1270. View abstract.
  744. van der Helm-van Mil AH, van Someren, E. J., van den, Boom R., van Buchem, M. A., de Craen, A. J., and Blauw, G. J. No influence of melatonin on cerebral blood flow in humans. J Clin Endocrinol.Metab 2003;88:5989-5994. View abstract.
  745. Crowley, S. J., Lee, C., Tseng, C. Y., Fogg, L. F., and Eastman, C. I. Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. J Biol.Rhythms 2003;18:513-523. View abstract.
  746. Singer, C., Tractenberg, R. E., Kaye, J., Schafer, K., Gamst, A., Grundman, M., Thomas, R., and Thal, L. J. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep 11-1-2003;26:893-901. View abstract.
  747. Hartter, S., Nordmark, A., Rose, D. M., Bertilsson, L., Tybring, G., and Laine, K. Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity. Br.J.Clin.Pharmacol. 2003;56:679-682. View abstract.
  748. Yan, J. J., Shen, F., Wang, K., and Wu, M. C. Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. Hepatobiliary.Pancreat.Dis.Int. 2002;1:183-186. View abstract.
  749. Fischer, S., Smolnik, R., Herms, M., Born, J., and Fehm, H. L. Melatonin acutely improves the neuroendocrine architecture of sleep in blind individuals. J Clin Endocrinol.Metab 2003;88:5315-5320. View abstract.
  750. Ressmeyer, A. R., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D. X., Poeggeler, B., Antolin, I., Zsizsik, B. K., Reiter, R. J., and Hardeland, R. Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox.Rep. 2003;8:205-213. View abstract.
  751. Aman, M. G., Lam, K. S., and Collier-Crespin, A. Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of Ohio. J.Autism Dev.Disord. 2003;33:527-534. View abstract.
  752. Boeve, B. F., Silber, M. H., and Ferman, T. J. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med. 2003;4:281-284. View abstract.
  753. Hack, L. M., Lockley, S. W., Arendt, J., and Skene, D. J. The effects of low-dose 0.5-mg melatonin on the free-running circadian rhythms of blind subjects. J Biol.Rhythms 2003;18:420-429. View abstract.
  754. Smits, M. G., van Stel, H. F., van der, Heijden K., Meijer, A. M., Coenen, A. M., and Kerkhof, G. A. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. J Am Acad.Child Adolesc.Psychiatry 2003;42:1286-1293. View abstract.
  755. Sletten, T., Burgess, H., Savic, N., Gilbert, S., and Dawson, D. The effects of bright light and nighttime melatonin administration on cardiac activity. J Hum.Ergol.(Tokyo) 2001;30(1-2):273-278. View abstract.
  756. Lewy, A. J., Emens, J., Sack, R. L., Hasler, B. P., and Bernert, R. A. Zeitgeber hierarchy in humans: resetting the circadian phase positions of blind people using melatonin. Chronobiol.Int. 2003;20:837-852. View abstract.
  757. Lissoni, P., Malugani, F., Brivio, F., Piazza, A., Vintimilla, C., Giani, L., and Tancini, G. Total pineal endocrine substitution therapy (TPEST) as a new neuroendocrine palliative treatment of untreatable metastatic solid tumor patients: a phase II study. Neuro.Endocrinol.Lett. 2003;24(3-4):259-262. View abstract.
  758. Rozen, T. D. Melatonin as treatment for idiopathic stabbing headache. Neurology 9-23-2003;61:865-866. View abstract.
  759. L'Hermite-Baleriaux, M. and de Launoit, Y. Is melatonin really an in vitro inhibitor of human breast cancer cell proliferation? In Vitro Cell Dev.Biol 1992;28A(9-10):583-584. View abstract.
  760. Sandyk, R. Melatonin and maturation of REM sleep. Int J Neurosci 1992;63(1-2):105-114. View abstract.
  761. Viviani, S., Bidoli, P., Spinazze, S., Rovelli, F., and Lissoni, P. Normalization of the light/dark rhythm of melatonin after prolonged subcutaneous administration of interleukin-2 in advanced small cell lung cancer patients. J Pineal Res 1992;12:114-117. View abstract.
  762. Palazidou, E., Skene, D., Arendt, J., Everitt, B., and Checkley, S. A. The acute and chronic effects of (+) and (-) oxaprotiline upon melatonin secretion in normal subjects. Psychol Med 1992;22:61-67. View abstract.
  763. Barni, S., Lissoni, P., Cazzaniga, M., Ardizzoia, A., Paolorossi, F., Brivio, F., Perego, M., Tancini, G., Conti, A., and Maestroni, G. Neuroimmunotherapy with subcutaneous low-dose interleukin-2 and the pineal hormone melatonin as a second-line treatment in metastatic colorectal carcinoma. Tumori 12-31-1992;78:383-387. View abstract.
  764. Rajaratnam, S. M., Dijk, D. J., Middleton, B., Stone, B. M., and Arendt, J. Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormones. J Clin Endocrinol.Metab 2003;88:4303-4309. View abstract.
  765. Lissoni, P., Barni, S., Ardizzoia, A., Brivio, F., Tancini, G., Conti, A., and Maestroni, G. J. Immunological effects of a single evening subcutaneous injection of low- dose interleukin-2 in association with the pineal hormone melatonin in advanced cancer patients. J Biol Regul Homeost.Agents 1992;6:132-136. View abstract.
  766. Niederhofer, H., Staffen, W., Mair, A., and Pittschieler, K. Brief report: melatonin facilitates sleep in individuals with mental retardation and insomnia. J Autism Dev.Disord. 2003;33:469-472. View abstract.
  767. Rogers, N. L., Kennaway, D. J., and Dawson, D. Neurobehavioural performance effects of daytime melatonin and temazepam administration. J Sleep Res 2003;12:207-212. View abstract.
  768. Naidu, P. S., Singh, A., and Kulkarni, S. K. Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action. J.Med.Food 2003;6:107-114. View abstract.
  769. Shiu, S. Y., Law, I. C., Lau, K. W., Tam, P. C., Yip, A. W., and Ng, W. T. Melatonin slowed the early biochemical progression of hormone-refractory prostate cancer in a patient whose prostate tumor tissue expressed MT1 receptor subtype. J Pineal Res 2003;35:177-182. View abstract.
  770. Asayama, K., Yamadera, H., Ito, T., Suzuki, H., Kudo, Y., and Endo, S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 2003;70:334-341. View abstract.
  771. Ursing, C., Wikner, J., Brismar, K., and Rojdmark, S. Caffeine raises the serum melatonin level in healthy subjects: an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26:403-406. View abstract.
  772. Topsakal, C., Kilic, N., Ozveren, F., Akdemir, I., Kaplan, M., Tiftikci, M., and Gursu, F. Effects of Prostaglandin E1, Melatonin, and Oxytetracycline on Lipid Peroxidation, Antioxidant Defense System, Paraoxonase (PON1) Activities, and Homocysteine Levels in an Animal Model of Spinal Cord Injury. Spine 8-1-2003;28:1643-1652. View abstract.
  773. Chen, K. B., Lin, A. M., and Chiu, T. H. Oxidative injury to the locus coeruleus of rat brain: neuroprotection by melatonin. J Pineal Res 2003;35:109-117. View abstract.
  774. Cabeza, J., Alarcon-de-la-Lastra, C., Jimenez, D., Martin, M. J., and Motilva, V. Melatonin modulates the effects of gastric injury in rats: role of prostaglandins and nitric oxide. Neurosignals. 2003;12:71-77. View abstract.
  775. Ray, C. A. Melatonin attenuates the sympathetic nerve responses to orthostatic stress in humans. J Physiol 9-15-2003;551(Pt 3):1043-1048. View abstract.
  776. Koc, M., Taysi, S., Emin, Buyukokuroglu M., and Bakan, N. The effect of melatonin against oxidative damage during total-body irradiation in rats. Radiat.Res 2003;160:251-255. View abstract.
  777. Reiter, R. J., Sainz, R. M., Lopez-Burillo, S., Mayo, J. C., Manchester, L. C., and Tan, D. X. Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke. Ann.N.Y.Acad.Sci. 2003;993:35-47. View abstract.
  778. Jonage-Canonico, M. B., Lenoir, V., Martin, A., Scholler, R., and Kerdelhue, B. Long term inhibition by Estradiol or Progesterone of Melatonin secretion after administration of a mammary carcinogen, the dimethyl benz(a)anthracene, in Sprague-Dawley female rat; inhibitory effect of Melatonin on mammary carcinogenesis. Breast Cancer Res Treat. 2003;79:365-377. View abstract.
  779. Nelson, L. A., McGuire, J. M., and Hausafus, S. N. Melatonin for the treatment of tardive dyskinesia. Ann.Pharmacother. 2003;37(7-8):1128-1131. View abstract.
  780. Sener, G., Sehirli, A. O., and Ayanoglu-Dulger, G. Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study. J Pineal Res 2003;35:61-68. View abstract.
  781. Bikjdaouene, L., Escames, G., Leon, J., Ferrer, J. M., Khaldy, H., Vives, F., and Acuna-Castroviejo, D. Changes in brain amino acids and nitric oxide after melatonin administration in rats with pentylenetetrazole-induced seizures. J Pineal Res 2003;35:54-60. View abstract.
  782. Lissoni, P., Chilelli, M., Villa, S., Cerizza, L., and Tancini, G. Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J Pineal Res 2003;35:12-15. View abstract.
  783. Cerea, G., Vaghi, M., Ardizzoia, A., Villa, S., Bucovec, R., Mengo, S., Gardani, G., Tancini, G., and Lissoni, P. Biomodulation of cancer chemotherapy for metastatic colorectal cancer: a randomized study of weekly low-dose irinotecan alone versus irinotecan plus the oncostatic pineal hormone melatonin in metastatic colorectal cancer patients progressing on 5-fluorouracil-containing combinations. Anticancer Res 2003;23(2C):1951-1954. View abstract.
  784. Paavonen, E. J., Nieminen-Von Wendt, T., Vanhala, R., Aronen, E. T., and Von Wendt, L. Effectiveness of melatonin in the treatment of sleep disturbances in children with asperger disorder. J Child Adolesc.Psychopharmacol. 2003;13:83-95. View abstract.
  785. Mayo, J. C., Tan, D. X., Sainz, R. M., Lopez-Burillo, S., and Reiter, R. J. Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free Radic.Res 2003;37:543-553. View abstract.
  786. Almeida Montes, L. G., Ontiveros Uribe, M. P., Cortes, Sotres J., and Heinze, Martin G. Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study. J Psychiatry Neurosci. 2003;28:191-196. View abstract.
  787. Bizzarri, M., Cucina, A., Valente, M. G., Tagliaferri, F., Borrelli, V., Stipa, F., and Cavallaro, A. Melatonin and vitamin D3 increase TGF-beta1 release and induce growth inhibition in breast cancer cell cultures. J Surg Res 2003;110:332-337. View abstract.
  788. Reiter, R. J. Melatonin: clinical relevance. Best.Pract.Res Clin Endocrinol.Metab 2003;17:273-285. View abstract.
  789. Kripke, D. F., Youngstedt, S. D., Rex, K. M., Klauber, M. R., and Elliott, J. A. Melatonin excretion with affect disorders over age 60. Psychiatry Res 5-1-2003;118:47-54. View abstract.
  790. Lissoni, P., Malugani, F., Bukovec, R., Bordin, V., Perego, M., Mengo, S., Ardizzoia, A., and Tancini, G. Reduction of cisplatin-induced anemia by the pineal indole 5-methoxytryptamine in metastatic lung cancer patients. Neuro.Endocrinol.Lett. 2003;24(1-2):83-85. View abstract.
  791. Leppamaki, S., Partonen, T., Vakkuri, O., Lonnqvist, J., Partinen, M., and Laudon, M. Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur.Neuropsychopharmacol. 2003;13:137-145. View abstract.
  792. Owens, J. A., Rosen, C. L., and Mindell, J. A. Medication use in the treatment of pediatric insomnia: results of a survey of community-based pediatricians. Pediatrics 2003;111(5 Pt 1):e628-e635. View abstract.
  793. Chen, G., Huo, Y., Tan, D. X., Liang, Z., Zhang, W., and Zhang, Y. Melatonin in Chinese medicinal herbs. Life Sci. 5-23-2003;73:19-26. View abstract.
  794. Sahna, E., Parlakpinar, H., Ozturk, F., Cigremis, Y., and Acet, A. The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats. Urol.Res 2003;31:188-193. View abstract.
  795. Kocak, G., Erbil, K. M., Ozdemir, I., Aydemir, S., Sunar, B., Tuncel, M., and Atalay, S. The protective effect of melatonin on adriamycin-induced acute cardiac injury. Can J Cardiol. 2003;19:535-541. View abstract.
  796. Abilio, V. C., Vera, J. A., Jr., Ferreira, L. S., Duarte, C. R., Martins, C. R., Torres-Leite, D., Ribeiro, Rde A., and Frussa-Filho, R. Effects of melatonin on behavioral dopaminergic supersensitivity. Life Sci. 5-16-2003;72:3003-3015. View abstract.
  797. Zhou, M. O., Jiao, S., Liu, Z., Zhang, Z. H., and Mei, Y. A. Luzindole, a melatonin receptor antagonist, inhibits the transient outward K+ current in rat cerebellar granule cells. Brain Res 4-25-2003;970(1-2):169-177. View abstract.
  798. Arias, J., Melean, E., Valero, N., Pons, H., Chacin-Bonilla, L., Larreal, Y., and Bonilla, E. [Effect of melatonin on lymphocyte proliferation and production of interleukin-2 (IL-2) and interleukin-1 beta (IL-1 beta) in mice splenocytes]. Invest Clin 2003;44:41-50. View abstract.
  799. Chen, Z., Chua, C. C., Gao, J., Hamdy, R. C., and Chua, B. H. Protective effect of melatonin on myocardial infarction. Am.J Physiol Heart Circ.Physiol 2003;284:H1618-H1624. View abstract.
  800. Sener, G., Tosun, O., Sehirli, A. O., Kacmaz, A., Arbak, S., Ersoy, Y., and Ayanoglu-Dulger, G. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci. 5-2-2003;72:2707-2718. View abstract.
  801. Bordet, R., Devos, D., Brique, S., Touitou, Y., Guieu, J. D., Libersa, C., and Destee, A. Study of circadian melatonin secretion pattern at different stages of Parkinson's disease. Clin Neuropharmacol. 2003;26:65-72. View abstract.
  802. Reiter, R. J. and Tan, D. X. Melatonin: a novel protective agent against oxidative injury of the ischemic/reperfused heart. Cardiovasc.Res 4-1-2003;58:10-19. View abstract.
  803. Karasek, M., Gruszka, A., Lawnicka, H., Kunert-Radek, J., and Pawlikowski, M. Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors. J Pineal Res 2003;34:294-296. View abstract.
  804. Gulcin, I., Buyukokuroglu, M. E., and Kufrevioglu, O. I. Metal chelating and hydrogen peroxide scavenging effects of melatonin. J Pineal Res 2003;34:278-281. View abstract.
  805. Lopez-Burillo, S., Tan, D. X., Mayo, J. C., Sainz, R. M., Manchester, L. C., and Reiter, R. J. Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions. J Pineal Res 2003;34:269-277. View abstract.
  806. Chen, J. C., Ng, C. J., Chiu, T. F., and Chen, H. M. Altered neutrophil apoptosis activity is reversed by melatonin in liver ischemia-reperfusion. J Pineal Res 2003;34:260-264. View abstract.
  807. Tan, D. X., Hardeland, R., Manchester, L. C., Poeggeler, B., Lopez-Burillo, S., Mayo, J. C., Sainz, R. M., and Reiter, R. J. Mechanistic and comparative studies of melatonin and classic antioxidants in terms of their interactions with the ABTS cation radical. J Pineal Res 2003;34:249-259. View abstract.
  808. Vachharajani, N. N., Yeleswaram, K., and Boulton, D. W. Preclinical pharmacokinetics and metabolism of BMS-214778, a novel melatonin receptor agonist. J Pharm Sci. 2003;92:760-772. View abstract.
  809. Ivanenko, A., Crabtree, V. M., Tauman, R., and Gozal, D. Melatonin in children and adolescents with insomnia: a retrospective study. Clin Pediatr.(Phila) 2003;42:51-58. View abstract.
  810. Todisco, M., Casaccia, P., and Rossi, N. Severe bleeding symptoms in refractory idiopathic thrombocytopenic purpura: a case successfully treated with melatonin. Am.J Ther 2003;10:135-136. View abstract.
  811. Delagrange, P., Atkinson, J., Boutin, J. A., Casteilla, L., Lesieur, D., Misslin, R., Pellissier, S., Penicaud, L., and Renard, P. Therapeutic perspectives for melatonin agonists and antagonists. J Neuroendocrinol. 2003;15:442-448. View abstract.
  812. Baskett, J. J., Broad, J. B., Wood, P. C., Duncan, J. R., Pledger, M. J., English, J., and Arendt, J. Does melatonin improve sleep in older people? A randomised crossover trial. Age Ageing 2003;32:164-170. View abstract.
  813. Sainz, R. M., Mayo, J. C., Tan, D. X., Lopez-Burillo, S., Natarajan, M., and Reiter, R. J. Antioxidant activity of melatonin in Chinese hamster ovarian cells: changes in cellular proliferation and differentiation. Biochem.Biophys.Res Commun. 3-14-2003;302:625-634. View abstract.
  814. Sener, G., Sehirli, A. O., Paskaloglu, K., Dulger, G. A., and Alican, I. Melatonin treatment protects against ischemia/reperfusion-induced functional and biochemical changes in rat urinary bladder. J Pineal Res 2003;34:226-230. View abstract.
  815. Pei, Z. and Cheung, R. T. Melatonin protects SHSY5Y neuronal cells but not cultured astrocytes from ischemia due to oxygen and glucose deprivation. J Pineal Res 2003;34:194-201. View abstract.
  816. Taysi, S., Koc, M., Buyukokuroglu, M. E., Altinkaynak, K., and Sahin, Y. N. Melatonin reduces lipid peroxidation and nitric oxide during irradiation-induced oxidative injury in the rat liver. J Pineal Res 2003;34:173-177. View abstract.
  817. Cheung, R. T. The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion. J Pineal Res 2003;34:153-160. View abstract.
  818. Dericks-Tan, J. S., Schwinn, P., and Hildt, C. Dose-dependent stimulation of melatonin secretion after administration of agnus castus. Exp.Clin Endocrinol.Diabetes 2003;111:44-46. View abstract.
  819. Dziegiel, P., Surowiak, P., Rabczynski, J., and Zabel, M. Effect of melatonin on cytotoxic effects of daunorubicin on myocardium and on transplantable Morris hepatoma in rats. Pol.J Pathol. 2002;53:201-204. View abstract.
  820. Mayo, J. C., Tan, D. X., Sainz, R. M., Natarajan, M., Lopez-Burillo, S., and Reiter, R. J. Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants. Biochim.Biophys.Acta 3-17-2003;1620(1-3):139-150. View abstract.
  821. Ardura, J., Gutierrez, R., Andres, J., and Agapito, T. Emergence and evolution of the circadian rhythm of melatonin in children. Horm.Res 2003;59:66-72. View abstract.
  822. Zhang, J., Guo, J. D., Xing, S. H., Gu, S. L., and Dai, T. J. [The protective effects of melatonin on global cerebral ischemia-reperfusion injury in gerbils]. Yao Xue.Xue.Bao. 2002;37:329-333. View abstract.
  823. Zhou, Y. H., Huo, Z. Y., and Qiu, X. C. [Inhibitory effect of melatonin on morphine withdrawal syndromes and the content of NO in plasma and brain tissue in morphine dependent mice]. Yao Xue.Xue.Bao. 2002;37:175-177. View abstract.
  824. Buxton, O. M., Lee, C. W., L'Hermite-Baleriaux, M., Turek, F. W., and Van Cauter, E. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase. Am.J Physiol Regul.Integr.Comp Physiol 2003;284:R714-R724. View abstract.
  825. Zhang, Z. and Yu, C. X. [Effect of melatonin on learning and memory impairment induced by aluminum chloride and its mechanism]. Yao Xue.Xue.Bao. 2002;37:682-686. View abstract.
  826. Pei, Z., Fung, P. C., and Cheung, R. T. Melatonin reduces nitric oxide level during ischemia but not blood-brain barrier breakdown during reperfusion in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2003;34:110-118. View abstract.
  827. Chung, S. Y. and Han, S. H. Melatonin attenuates kainic acid-induced hippocampal neurodegeneration and oxidative stress through microglial inhibition. J Pineal Res 2003;34:95-102. View abstract.
  828. Cardinali, D. P., Ladizesky, M. G., Boggio, V., Cutrera, R. A., and Mautalen, C. Melatonin effects on bone: experimental facts and clinical perspectives. J Pineal Res 2003;34:81-87. View abstract.
  829. Naidu, P. S., Singh, A., Kaur, P., Sandhir, R., and Kulkarni, S. K. Possible mechanism of action in melatonin attenuation of haloperidol-induced orofacial dyskinesia. Pharmacol.Biochem.Behav 2003;74:641-648. View abstract.
  830. Wang, F., Li, J., Wu, C., Yang, J., Xu, F., and Zhao, Q. The GABA(A) receptor mediates the hypnotic activity of melatonin in rats. Pharmacol.Biochem.Behav 2003;74:573-578. View abstract.
  831. Doyle, S. E., Grace, M. S., McIvor, W., and Menaker, M. Circadian rhythms of dopamine in mouse retina: the role of melatonin. Vis.Neurosci. 2002;19:593-601. View abstract.
  832. Singh, P., Bhargava, V. K., and Garg, S. K. Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury. Indian J Physiol Pharmacol. 2002;46:229-234. View abstract.
  833. Fowler, G., Daroszewska, M., and Ingold, K. U. Melatonin does not "directly scavenge hydrogen peroxide": demise of another myth. Free Radic.Biol.Med 1-1-2003;34:77-83. View abstract.
  834. Reiter, R. J. and Tan, D. X. What constitutes a physiological concentration of melatonin? J Pineal Res 2003;34:79-80. View abstract.
  835. Tan, D. X., Manchester, L. C., Hardeland, R., Lopez-Burillo, S., Mayo, J. C., Sainz, R. M., and Reiter, R. J. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003;34:75-78. View abstract.
  836. Kaptanoglu, E., Palaoglu, S., Demirpence, E., Akbiyik, F., Solaroglu, I., and Kilinc, A. Different responsiveness of central nervous system tissues to oxidative conditions and to the antioxidant effect of melatonin. J Pineal Res 2003;34:32-35. View abstract.
  837. Gwayi, N. and Bernard, R. T. The effects of melatonin on sperm motility in vitro in Wistar rats. Andrologia 2002;34:391-396. View abstract.
  838. Serfaty, M., Kennell-Webb, S., Warner, J., Blizard, R., and Raven, P. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr.Psychiatry 2002;17:1120-1127. View abstract.
  839. Todisco, M. and Rossi, N. Melatonin for refractory idiopathic thrombocytopenic purpura: a report of 3 cases. Am.J Ther 2002;9:524-526. View abstract.
  840. Reiter, R. J., Tan, D. X., Sainz, R. M., Mayo, J. C., and Lopez-Burillo, S. Melatonin: reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacol. 2002;54:1299-1321. View abstract.
  841. Sahna, E., Acet, A., Ozer, M. K., and Olmez, E. Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pineal Res 2002;33:234-238. View abstract.
  842. Bothorel, B., Barassin, S., Saboureau, M., Perreau, S., Vivien-Roels, B., Malan, A., and Pevet, P. In the rat, exogenous melatonin increases the amplitude of pineal melatonin secretion by a direct action on the circadian clock. Eur.J Neurosci. 2002;16:1090-1098. View abstract.
  843. Rufo-Campos, M. [Melatonin and epilepsy]. Rev Neurol. 2002;35 Suppl 1:S51-S58. View abstract.
  844. Montilla-Lopez, P., Munoz-Agueda, M. C., Feijoo, Lopez M., Munoz-Castaneda, J. R., Bujalance-Arenas, I., and Tunez-Finana, I. Comparison of melatonin versus vitamin C on oxidative stress and antioxidant enzyme activity in Alzheimer's disease induced by okadaic acid in neuroblastoma cells. Eur.J Pharmacol. 9-20-2002;451:237-243. View abstract.
  845. Fischer, T. W., Scholz, G., Knoll, B., Hipler, U. C., and Elsner, P. Melatonin suppresses reactive oxygen species in UV-irradiated leukocytes more than vitamin C and trolox. Skin Pharmacol.Appl.Skin Physiol 2002;15:367-373. View abstract.
  846. Adams, J. D., Jr., Yang, J., Mishra, L. C., and Singh, B. B. Effects of ashwagandha in a rat model of stroke. Altern Ther Health Med 2002;8:18-19. View abstract.
  847. Bilici, D., Akpinar, E., and Kiziltunc, A. Protective effect of melatonin in carrageenan-induced acute local inflammation. Pharmacol.Res 2002;46:133-139. View abstract.
  848. Gulcin, I., Buyukokuroglu, M. E., Oktay, M., and Kufrevioglu, O. I. On the in vitro antioxidative properties of melatonin. J Pineal Res 2002;33:167-171. View abstract.
  849. Dillon, D. C., Easley, S. E., Asch, B. B., Cheney, R. T., Brydon, L., Jockers, R., Winston, J. S., Brooks, J. S., Hurd, T., and Asch, H. L. Differential expression of high-affinity melatonin receptors (MT1) in normal and malignant human breast tissue. Am.J Clin Pathol. 2002;118:451-458. View abstract.
  850. Edwards, R. B., Manzana, E. J., and Chen, W. J. Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum. Alcohol Clin Exp.Res 2002;26:1003-1009. View abstract.
  851. Blask, D. E., Dauchy, R. T., Sauer, L. A., Krause, J. A., and Brainard, G. C. Light during darkness, melatonin suppression and cancer progression. Neuroendocrinol.Lett. 2002;23 Suppl 2:52-56. View abstract.
  852. Bonnefont-Rousselot, D., Cheve, G., Gozzo, A., Tailleux, A., Guilloz, V., Caisey, S., Teissier, E., Fruchart, J. C., Delattre, J., Jore, D., Lesieur, D., Duriez, P., and Gardes-Albert, M. Melatonin related compounds inhibit lipid peroxidation during copper or free radical-induced LDL oxidation. J Pineal Res 2002;33:109-117. View abstract.
  853. Dziegiel, P., Suder, E., Surowiak, P., Jethon, Z., Rabczynski, J., Januszewska, L., Sopel, M., and Zabel, M. Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat. J Pineal Res 2002;33:95-100. View abstract.
  854. Lee, Y. M., Chen, H. R., Hsiao, G., Sheu, J. R., Wang, J. J., and Yen, M. H. Protective effects of melatonin on myocardial ischemia/reperfusion injury in vivo. J Pineal Res 2002;33:72-80. View abstract.
  855. Valenti, S. and Giusti, M. Melatonin participates in the control of testosterone secretion from rat testis: an overview of our experience. Ann.N.Y.Acad.Sci. 2002;966:284-289. View abstract.
  856. Antolin, I., Mayo, J. C., Sainz, R. M., del Brio, Mde L., Herrera, F., Martin, V., and Rodriguez, C. Protective effect of melatonin in a chronic experimental model of Parkinson's disease. Brain Res 7-12-2002;943:163-173. View abstract.
  857. Koyama, H., Nakade, O., Takada, Y., Kaku, T., and Lau, K. H. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation. J Bone Miner.Res 2002;17:1219-1229. View abstract.
  858. Srivastava, A. K., Gupta, S. K., Jain, S., and Gupta, Y. K. Effect of melatonin and phenytoin on an intracortical ferric chloride model of posttraumatic seizures in rats. Methods Find.Exp.Clin Pharmacol. 2002;24:145-149. View abstract.
  859. Reiter, R. J. and Tan, D. X. Melatonin: an antioxidant in edible plants. Ann.N.Y.Acad.Sci. 2002;957:341-344. View abstract.
  860. Sahna, E., Olmez, E., and Acet, A. Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? J Pineal Res 2002;32:194-198. View abstract.
  861. Allegra, M., Gentile, C., Tesoriere, L., and Livrea, M. A. Protective effect of melatonin against cytotoxic actions of malondialdehyde: an in vitro study on human erythrocytes. J Pineal Res 2002;32:187-193. View abstract.
  862. Pita, M. L., Hoyos, M., Martin-Lacave, I., Osuna, C., Fernandez-Santos, J. M., and Guerrero, J. M. Long-term melatonin administration increases polyunsaturated fatty acid percentage in plasma lipids of hypercholesterolemic rats. J Pineal Res 2002;32:179-186. View abstract.
  863. Pei, Z., Pang, S. F., and Cheung, R. T. Pretreatment with melatonin reduces volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2002;32:168-172. View abstract.
  864. Pappolla, M. A., Simovich, M. J., Bryant-Thomas, T., Chyan, Y. J., Poeggeler, B., Dubocovich, M., Bick, R., Perry, G., Cruz-Sanchez, F., and Smith, M. A. The neuroprotective activities of melatonin against the Alzheimer beta- protein are not mediated by melatonin membrane receptors. J Pineal Res 2002;32:135-142. View abstract.
  865. Abilio, V. C., Vera, J. A., Jr., Ferreira, L. S., Duarte, C. R., Carvalho, R. C., Grassl, C., Martins, C. R., Torres-Leite, D., Bignotto, M., Tufik, S., Ribeiro, Rde A., and Frussa-Filho, R. Effects of melatonin on orofacial movements in rats. Psychopharmacology (Berl) 2002;161:340-347. View abstract.
  866. Johnson, K., Page, A., Williams, H., Wassemer, E., and Whitehouse, W. The use of melatonin as an alternative to sedation in uncooperative children undergoing an MRI examination. Clin Radiol. 2002;57:502-506. View abstract.
  867. Lewy, A. J., Emens, J. S., Sack, R. L., Hasler, B. P., and Bernert, R. A. Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period. Chronobiol.Int 2002;19:649-658. View abstract.
  868. Luboshitzky, R., Shen-Orr, Z., Nave, R., Lavi, S., and Lavie, P. Melatonin administration alters semen quality in healthy men. J Androl 2002;23:572-578. View abstract.
  869. Tailleux, A., Torpier, G., Bonnefont-Rousselot, D., Lestavel, S., Lemdani, M., Caudeville, B., Furman, C., Foricher, R., Gardes-Albert, M., Lesieur, D., Rolando, C., Teissier, E., Fruchart, J. C., Clavey, V., Fievet, C., and Duriez, P. Daily melatonin supplementation in mice increases atherosclerosis in proximal aorta. Biochem.Biophys.Res Commun. 5-10-2002;293:1114-1123. View abstract.
  870. Ross, C., Davies, P., and Whitehouse, W. Melatonin treatment for sleep disorders in children with neurodevelopmental disorders: an observational study. Dev Med Child Neurol 2002;44:339-344. View abstract.
  871. Koc, M., Buyukokuroglu, M. E., and Taysi, S. The effect of melatonin on peripheral blood cells during total body irradiation in rats. Biol.Pharm Bull. 2002;25:656-657. View abstract.
  872. Celebi, S., Dilsiz, N., Yilmaz, T., and Kukner, A. S. Effects of melatonin, vitamin E and octreotide on lipid peroxidation during ischemia-reperfusion in the guinea pig retina. Eur.J Ophthalmol. 2002;12:77-83. View abstract.
  873. Sewerynek, E. Melatonin and the cardiovascular system. Neuroendocrinol.Lett 2002;23 Suppl 1:79-83. View abstract.
  874. Lewinski, A. and Karbownik, M. REVIEW. Melatonin and the thyroid gland. Neuroendocrinol.Lett 2002;23 Suppl 1:73-78. View abstract.
  875. Cardinali, D. P., Brusco, L. I., Liberczuk, C., and Furio, A. M. The use of melatonin in Alzheimer's disease. Neuro.Endocrinol.Lett. 2002;23 Suppl 1:20-23. View abstract.
  876. Kvetnoy, I. M., Ingel, I. E., Kvetnaia, T. V., Malinovskaya, N. K., Rapoport, S. I., Raikhlin, N. T., Trofimov, A. V., and Yuzhakov, V. V. Gastrointestinal melatonin: cellular identification and biological role. Neuroendocrinol.Lett. 2002;23:121-132. View abstract.
  877. Holmes, A. L., Gilbert, S. S., and Dawson, D. Melatonin and zopiclone: the relationship between sleep propensity and body temperature. Sleep 5-1-2002;25:301-306. View abstract.
  878. Bhattacharya, S. K., Bhattacharya, D., Sairam, K., and Ghosal, S. Effect of Withania somnifera glycowithanolides on a rat model of tardive dyskinesia. Phytomedicine. 2002;9:167-170. View abstract.
  879. Bilici, D., Suleyman, H., Banoglu, Z. N., Kiziltunc, A., Avci, B., Ciftcioglu, A., and Bilici, S. Melatonin prevents ethanol-induced gastric mucosal damage possibly due to its antioxidant effect. Dig.Dis.Sci. 2002;47:856-861. View abstract.
  880. Gupta, Y. K., Chaudhary, G., and Sinha, K. Enhanced protection by melatonin and meloxicam combination in a middle cerebral artery occlusion model of acute ischemic stroke in rat. Can J Physiol Pharmacol. 2002;80:210-217. View abstract.
  881. Calvo, J. R., Guerrero, J. M., Osuna, C., Molinero, P., and Carrillo-Vico, A. Melatonin triggers Crohn's disease symptoms. J Pineal Res 2002;32:277-278. View abstract.
  882. Munoz-Hoyos, A., Heredia, F., Moreno, F., Garcia, J. J., Molina-Carballo, A., Escames, G., and Acuna-Castroviejo, D. Evaluation of plasma levels of melatonin after midazolam or sodium thiopental anesthesia in children. J Pineal Res 2002;32:253-256. View abstract.
  883. Reiter, R. J., Tan, D. X., Manchester, L. C., and El Sawi, M. R. Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging. Ann.N.Y.Acad.Sci 2002;959:238-250. View abstract.
  884. Feng, Y., Zhang, L. X., and Chao, D. M. [Role of melatonin in spatial learning and memory in rats and its mechanism]. Sheng Li Xue.Bao. 2-25-2002;54:65-70. View abstract.
  885. Dziegiel, P., Jethon, Z., Suder, E., Sopel, M., Rabczynski, J., Surowiak, P., and Zabel, M. Role of exogenous melatonin in reducing the cardiotoxic effect of daunorubicin and doxorubicin in the rat. Exp.Toxicol.Pathol. 2002;53:433-439. View abstract.
  886. Cuzzocrea, S. and Reiter, R. J. Pharmacological actions of melatonin in acute and chronic inflammation. Curr.Top.Med Chem. 2002;2:153-165. View abstract.
  887. Acuna, C. D., Escames, G., Carazo, A., Leon, J., Khaldy, H., and Reiter, R. J. Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr.Top.Med Chem. 2002;2:133-151. View abstract.
  888. Blask, D. E., Sauer, L. A., and Dauchy, R. T. Melatonin as a chronobiotic/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr.Top.Med Chem. 2002;2:113-132. View abstract.
  889. Awney, H. A., Attih, A. M., Habib, S. L., and Mostafa, M. H. Effect of melatonin on the production of microsomal hydrogen peroxide and cytochrome P-450 content in rat treated with aflatoxin B. Toxicology 3-20-2002;172:143-148. View abstract.
  890. Mohanan, P. V. and Yamamoto, H. A. Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid. Toxicol.Lett. 3-24-2002;129(1-2):99-105. View abstract.
  891. Arslan, S. O., Zerin, M., Vural, H., and Coskun, A. The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. J Pineal Res 2002;32:21-25. View abstract.
  892. Wirz-Justice, A., Werth, E., Renz, C., Muller, S., and Krauchi, K. No evidence for a phase delay in human circadian rhythms after a single morning melatonin administration. J Pineal Res 2002;32:1-5. View abstract.
  893. Beloosesky, Y., Grinblat, J., Laudon, M., Grosman, B., Streifler, J. Y., and Zisapel, N. Melatonin rhythms in stroke patients. Neurosci.Lett. 2-15-2002;319:103-106. View abstract.
  894. Iuvone, P. M., Brown, A. D., Haque, R., Weller, J., Zawilska, J. B., Chaurasia, S. S., Ma, M., and Klein, D. C. Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Invest Ophthalmol.Vis.Sci. 2002;43:564-572. View abstract.
  895. Hanania, M. and Kitain, E. Melatonin for treatment and prevention of postoperative delirium. Anesth.Analg. 2002;94:338-9, table. View abstract.
  896. Pei, Z., Ho, H. T., and Cheung, R. T. Pre-treatment with melatonin reduces volume of cerebral infarction in a permanent middle cerebral artery occlusion stroke model in the rat. Neurosci.Lett. 2-1-2002;318:141-144. View abstract.
  897. Gitto, E., Karbownik, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G., and Barberi, I. Effects of melatonin treatment in septic newborns. Pediatr Res 2001;50:756-760. View abstract.
  898. Pires, M. L., Benedito-Silva, A. A., Pinto, L., Souza, L., Vismari, L., and Calil, H. M. Acute effects of low doses of melatonin on the sleep of young healthy subjects. J.Pineal Res. 2001;31:326-332. View abstract.
  899. Sharkey, K. M., Fogg, L. F., and Eastman, C. I. Effects of melatonin administration on daytime sleep after simulated night shift work. J Sleep Res 2001;10:181-192. View abstract.
  900. Morera, A. L., Henry, M., and de, La, V. [Safety in melatonin use]. Actas Esp.Psiquiatr 2001;29:334-337. View abstract.
  901. Wakatsuki, A., Okatani, Y., Ikenoue, N., Shinohara, K., Watanabe, K., and Fukaya, T. Melatonin protects against oxidized low-density lipoprotein-induced inhibition of nitric oxide production in human umbilical artery. J Pineal Res 2001;31:281-288. View abstract.
  902. Granzotto, M., Rapozzi, V., Decorti, G., and Giraldi, T. Effects of melatonin on doxorubicin cytotoxicity in sensitive and pleiotropically resistant tumor cells. J Pineal Res 2001;31:206-213. View abstract.
  903. Harris, A. S., Burgess, H. J., and Dawson, D. The effects of day-time exogenous melatonin administration on cardiac autonomic activity. J Pineal Res 2001;31:199-205. View abstract.
  904. Gagnier, J. J. The therapeutic potential of melatonin in migraines and other headache types. Altern Med Rev 2001;6:383-389. View abstract.
  905. Rivkees, S. A. Arrhythmicity in a child with septo-optic dysplasia and establishment of sleep-wake cyclicity with melatonin. J Pediatr 2001;139:463-465. View abstract.
  906. Sjoblom, M., Jedstedt, G., and Flemstrom, G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001;108:625-633. View abstract.
  907. Suhner, A., Schlagenhauf, P., Hofer, I., Johnson, R., Tschopp, A., and Steffen, R. Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. Aviat.Space Environ.Med. 2001;72:638-646. View abstract.
  908. Reiter, R. J., Acuna-Castroviejo, D., Tan, D. X., and Burkhardt, S. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. Ann N Y Acad Sci 2001;939:200-215. View abstract.
  909. Karasek, M., Kowalski, A. J., and Zylinska, K. Serum melatonin circadian profile in women suffering from the genital tract cancers. Neuroendocrinol.Lett 2000;21:109-113. View abstract.
  910. Kulman, G., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., and Sequeri, P. Evidence of pineal endocrine hypofunction in autistic children. Neuro.Endocrinol.Lett. 2000;21:31-34. View abstract.
  911. Satomura, T., Sakamoto, T., Shirakawa, S., Tsutsumi, Y., Mukai, M., Ohyama, T., Uchimura, N., and Maeda, H. Hypnotic action of melatonin during daytime administration and its comparison with triazolam. Psychiatry Clin Neurosci. 2001;55:303-304. View abstract.
  912. Kitajima, T., Kanbayashi, T., Saitoh, Y., Ogawa, Y., Sugiyama, T., Kaneko, Y., Sasaki, Y., Aizawa, R., and Shimisu, T. The effects of oral melatonin on the autonomic function in healthy subjects. Psychiatry Clin Neurosci. 2001;55:299-300. View abstract.
  913. Takeuchi, N., Uchimura, N., Hashizume, Y., Mukai, M., Etoh, Y., Yamamoto, K., Kotorii, T., Ohshima, H., Ohshima, M., and Maeda, H. Melatonin therapy for REM sleep behavior disorder. Psychiatry Clin Neurosci. 2001;55:267-269. View abstract.
  914. Kim, B. C., Shon, B. S., Ryoo, Y. W., Kim, S. P., and Lee, K. S. Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts. J Dermatol Sci 2001;26:194-200. View abstract.
  915. Johnson, S. Micronutrient accumulation and depletion in schizophrenia, epilepsy, autism and Parkinson's disease? Med Hypotheses 2001;56:641-645. View abstract.
  916. Norman, T. R., Piccolo, J., Voudouris, N., and Burrows, G. D. The effect of single oral doses of zopiclone on nocturnal melatonin secretion in healthy male volunteers. Prog Neuropsychopharmacol.Biol Psychiatry 2001;25:825-833. View abstract.
  917. Ninomiya, T., Iwatani, N., Tomoda, A., and Miike, T. Effects of exogenous melatonin on pituitary hormones in humans. Clin Physiol 2001;21:292-299. View abstract.
  918. Goh, V. H., Tong, T. Y., Lim, C. L., Low, E. C., and Lee, L. K. Effects of one night of sleep deprivation on hormone profiles and performance efficiency. Mil.Med 2001;166:427-431. View abstract.
  919. Dai, J., Ram, P. T., Yuan, L., Spriggs, L. L., and Hill, S. M. Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin. Mol.Cell Endocrinol 5-15-2001;176(1-2):111-120. View abstract.
  920. Atkinson, G., Buckley, P., Edwards, B., Reilly, T., and Waterhouse, J. Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleep? Int J Sports Med 2001;22:232-234. View abstract.
  921. Yang, C. M., Spielman, A. J., D'Ambrosio, P., Serizawa, S., Nunes, J., and Birnbaum, J. A single dose of melatonin prevents the phase delay associated with a delayed weekend sleep pattern. Sleep 5-1-2001;24:272-281. View abstract.
  922. Kennaway, D. J., Flanagan, D. E., Moore, V. M., Cockington, R. A., Robinson, J. S., and Phillips, D. I. The impact of fetal size and length of gestation on 6- sulphatoxymelatonin excretion in adult life. J Pineal Res 2001;30:188-192. View abstract.
  923. Wakatsuki, A., Okatani, Y., Ikenoue, N., Kaneda, C., and Fukaya, T. Effects of short-term melatonin administration on lipoprotein metabolism in normolipidemic postmenopausal women. Maturitas 4-20-2001;38:171-177. View abstract.
  924. Graw, P., Werth, E., Krauchi, K., Gutzwiller, F., Cajochen, C., and Wirz-Justice, A. Early morning melatonin administration impairs psychomotor vigilance. Behav Brain Res 2001;121(1-2):167-172. View abstract.
  925. Hartter, S., Wang, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F., and Hiemke, C. Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. J Clin Psychopharmacol 2001;21:167-174. View abstract.
  926. Munoz-Hoyos, A., Hubber, E., Escames, G., Molina-Carballo, A., Macias, M., Valenzuela-Ruiz, A., Fernandez-Garcia, J. M., and Acuna-Castroviejo, D. Effect of propranolol plus exercise on melatonin and growth hormone levels in children with growth delay. J Pineal Res 2001;30:75-81. View abstract.
  927. Morera, A. L., Henry, M., Villaverde-Ruiz, M. L., and Gracia-Marco, R. [Efficiency of melatonin in the treatment of insomnia]. Actas Esp.Psiquiatr. 2000;28:325-329. View abstract.
  928. Reiter, R. J., Calvo, J. R., Karbownik, M., Qi, W., and Tan, D. X. Melatonin and its relation to the immune system and inflammation. Ann N.Y.Acad Sci 2000;917:376-386. View abstract.
  929. Cugini, P., Touitou, Y., Bogdan, A., Auzeby, A., Pellegrino, A. M., Fontana, S., Vacca, K., Siena, G. D., Di Rosa, R., Zannella, F. P., Zannella, P., Zannella, A., Sepe, F. A., and Sepe, L. Is melatonin circadian rhythm a physiological feature associated with healthy longevity? A study of long-living subjects and their progeny. Chronobiol Int 2001;18:99-107. View abstract.
  930. Kunz, D. and Bes, F. Exogenous melatonin in periodic limb movement disorder: an open clinical trial and a hypothesis. Sleep 3-15-2001;24:183-187. View abstract.
  931. Zaslavskaia, R. M., Biiasilov, N. S., Akhmetov, K. Z., and Teiblium, M. M. [Capozide-50 alone and in combination with melatonin in therapy of hypertension]. Klin.Med (Mosk) 2000;78:39-41. View abstract.
  932. Maestroni, G. J. The immunotherapeutic potential of melatonin. Expert.Opin Investig Drugs 2001;10:467-476. View abstract.
  933. Kayumov, L., Brown, G., Jindal, R., Buttoo, K., and Shapiro, C. M. A randomized, double-blind, placebo-controlled crossover study of the effect of exogenous melatonin on delayed sleep phase syndrome. Psychosom.Med 2001;63:40-48. View abstract.
  934. Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Facchinetti, F., Malmusi, S., and Volpe, A. Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replacement therapy. Clin Endocrinol (Oxf) 2001;54:261-266. View abstract.
  935. Hayashi, E. Effect of melatonin on sleep-wake rhythm: the sleep diary of an autistic male. Psychiatry Clin Neurosci. 2000;54:383-384. View abstract.
  936. Kamei, Y., Hayakawa, T., Urata, J., Uchiyama, M., Shibui, K., Kim, K., Kudo, Y., and Okawa, M. Melatonin treatment for circadian rhythm sleep disorders. Psychiatry Clin Neurosci. 2000;54:381-382. View abstract.
  937. Siegrist, C., Benedetti, C., Orlando, A., Beltran, J. M., Tuchscherr, L., Noseda, C. M., Brusco, L. I., and Cardinali, D. P. Lack of changes in serum prolactin, FSH, TSH, and estradiol after melatonin treatment in doses that improve sleep and reduce benzodiazepine consumption in sleep-disturbed, middle-aged, and elderly patients. J Pineal Res 2001;30:34-42. View abstract.
  938. Nakamura, Y., Tamura, H., Kashida, S., Takayama, H., Yamagata, Y., Karube, A., Sugino, N., and Kato, H. Changes of serum melatonin level and its relationship to feto-placental unit during pregnancy. J Pineal Res 2001;30:29-33. View abstract.
  939. Rea, M. S., Bullough, J. D., and Figueiro, M. G. Human melatonin suppression by light: a case for scotopic efficiency. Neurosci.Lett 2-16-2001;299(1-2):45-48. View abstract.
  940. Okatani, Y., Wakatsuki, A., and Reiter, R. J. Melatonin counteracts potentiation by homocysteine of KCL-induced vasoconstriction in human umbilical artery: relation to calcium influx. Biochem Biophys Res Commun. 1-26-2001;280:940-944. View abstract.
  941. Bartsch, H., Buchberger, A., Franz, H., Bartsch, C., Maidonis, I., Mecke, D., and Bayer, E. Effect of melatonin and pineal extracts on human ovarian and mammary tumor cells in a chemosensitivity assay. Life Sci 11-3-2000;67:2953-2960. View abstract.
  942. Fourtillan, J. B., Brisson, A. M., Fourtillan, M., Ingrand, I., Decourt, J. P., and Girault, J. Melatonin secretion occurs at a constant rate in both young and older men and women. Am J Physiol Endocrinol Metab 2001;280:E11-E22. View abstract.
  943. Shamir, E., Rotenberg, V. S., Laudon, M., Zisapel, N., and Elizur, A. First-night effect of melatonin treatment in patients with chronic schizophrenia. J Clin Psychopharmacol 2000;20:691-694. View abstract.
  944. Edwards, B. J., Atkinson, G., Waterhouse, J., Reilly, T., Godfrey, R., and Budgett, R. Use of melatonin in recovery from jet-lag following an eastward flight across 10 time-zones. Ergonomics 2000;43:1501-1513. View abstract.
  945. Marelli, M. M., Limonta, P., Maggi, R., Motta, M., and Moretti, R. M. Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells. Prostate 11-1-2000;45:238-244. View abstract.
  946. de Lourdes, M., Seabra, V., Bignotto, M., Pinto, L. R., Jr., and Tufik, S. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. J Pineal Res 2000;29:193-200. View abstract.
  947. Cagnacci, A., Arangino, S., Angiolucci, M., Melis, G. B., Tarquini, R., Renzi, A., and Volpe, A. Different circulatory response to melatonin in postmenopausal women without and with hormone replacement therapy. J Pineal Res 2000;29:152-158. View abstract.
  948. Jan, M. M. Melatonin for the treatment of handicapped children with severe sleep disorders. Pediatr Neurol 2000;23:229-232. View abstract.
  949. Pillar, G., Shahar, E., Peled, N., Ravid, S., Lavie, P., and Etzioni, A. Melatonin improves sleep-wake patterns in psychomotor retarded children. Pediatr Neurol 2000;23:225-228. View abstract.
  950. Monti, J. M. and Cardinali, D. P. A critical assessment of the melatonin effect on sleep in humans. Biol Signals Recept. 2000;9:328-339. View abstract.
  951. Cohen-Mansfield, J., Garfinkel, D., and Lipson, S. Melatonin for treatment of sundowning in elderly persons with dementia - a preliminary study. Arch.Gerontol.Geriatr. 8-1-2000;31:65-76. View abstract.
  952. Kancheva, R., Zofkova, I., Hill, M., and Kanchev, L. Lack of melatonin response to acute administration of nifedipine and diltiazem in healthy men. Physiol Res 2000;49 Suppl 1:S119-S124. View abstract.
  953. Shamir, E., Barak, Y., Plopsky, I., Zisapel, N., Elizur, A., and Weizman, A. Is melatonin treatment effective for tardive dyskinesia? J Clin Psychiatry 2000;61:556-558. View abstract.
  954. Karasek, M., Czernicki, J., Woldanska-Okonska, M., Zylinska, K., and Swietoslawski, J. Chronic exposure to 25-80-microT, 200-Hz magnetic field does not influence serum melatonin concentrations in patients with low back pain. J Pineal Res 2000;29:81-85. View abstract.
  955. Jockovich, M., Cosentino, D., Cosentino, L., Wears, R. L., and Seaberg, D. C. Effect of exogenous melatonin on mood and sleep efficiency in emergency medicine residents working night shifts. Acad Emerg.Med 2000;7:955-958. View abstract.
  956. Jan, J. E., Hamilton, D., Seward, N., Fast, D. K., Freeman, R. D., and Laudon, M. Clinical trials of controlled-release melatonin in children with sleep- wake cycle disorders. J Pineal Res 2000;29:34-39. View abstract.
  957. Brainard, G. C., Rollag, M. D., Hanifin, J. P., van den, Beld G., and Sanford, B. The effect of polarized versus nonpolarized light on melatonin regulation in humans. Photochem.Photobiol. 2000;71:766-770. View abstract.
  958. Zaslavskaia, R. M., Komarov, F. I., Shakirova, A. N., Teiblium, M. M., and Akhmetov, K. Z. [Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension]. Klin.Med (Mosk) 2000;78:41-44. View abstract.
  959. Bersani, G. and Garavini, A. Melatonin add-on in manic patients with treatment resistant insomnia. Prog.Neuropsychopharmacol.Biol.Psychiatry 2000;24:185-191. View abstract.
  960. Cos, S. and Sanchez-Barcelo, E. J. Melatonin and mammary pathological growth. Front Neuroendocrinol. 2000;21:133-170. View abstract.
  961. Dalton, E. J., Rotondi, D., Levitan, R. D., Kennedy, S. H., and Brown, G. M. Use of slow-release melatonin in treatment-resistant depression. J Psychiatry Neurosci. 2000;25:48-52. View abstract.
  962. Zaslavskaia, R. M., Shakirova, A. N., Komarov, F. I., Teiblium, M. M., and Akhmetov, K. Z. [Effects of melatonin alone and in combination with aceten on chronostructure of diurnal hemodynamic rhythms in patients with hypertension stage II]. Ter Arkh. 1999;71:21-24. View abstract.
  963. Luboshitzky, R., Shen-Orr, Z., Shochat, T., Herer, P., and Lavie, P. Melatonin administered in the afternoon decreases next-day luteinizing hormone levels in men: lack of antagonism by flumazenil. J Mol.Neurosci. 1999;12:75-80. View abstract.
  964. Ross, C., Morris, B., and Whitehouse, W. 'Melatonin treatment of sleep-wake cycle disorders in children and adolescents'. Dev Med Child Neurol 1999;41:850. View abstract.
  965. Pepping, J. Melatonin. Am J Health Syst.Pharm 12-15-1999;56:2520, 2523-2524, 2527. View abstract.
  966. Luboshitzky, R., Levi, M., Shen-Orr, Z., Blumenfeld, Z., Herer, P., and Lavie, P. Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men. Hum Reprod. 2000;15:60-65. View abstract.
  967. Lockley, S. W., Skene, D. J., James, K., Thapan, K., Wright, J., and Arendt, J. Melatonin administration can entrain the free-running circadian system of blind subjects. J Endocrinol 2000;164:R1-R6. View abstract.
  968. Yamashita, Y., Matsuishi, T., Murakami, Y., and Kato, H. Sleep disorder in Rett syndrome and melatonin treatment. Brain Dev. 1999;21:570. View abstract.
  969. Zhdanova, I. V. and Raz, D. J. Effects of melatonin ingestion on cAMP and cGMP levels in human plasma. J Endocrinol 1999;163:457-462. View abstract.
  970. Ishizaki, A., Sugama, M., and Takeuchi, N. [Usefulness of melatonin for developmental sleep and emotional/behavior disorders--studies of melatonin trial on 50 patients with developmental disorders]. No To Hattatsu 1999;31:428-437. View abstract.
  971. Wikner, J., Wetterberg, L., and Rojdmark, S. The role of somatostatin (octreotide) in the regulation of melatonin secretion in healthy volunteers and in patients with primary hypothyroidism. J Endocrinol Invest 1999;22:527-534. View abstract.
  972. Matsumoto, M. The hypnotic effects of melatonin treatment on diurnal sleep in humans. Psychiatry Clin.Neurosci. 1999;53:243-245. View abstract.
  973. Raghavendra, V. and Kulkarni, S. K. Reversal of morphine tolerance and dependence by melatonin: possible role of central and peripheral benzodiazepine receptors. Brain Res 7-10-1999;834(1-2):178-181. View abstract.
  974. Zhdanova, I. V., Wurtman, R. J., and Wagstaff, J. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J Pediatr Endocrinol Metab 1999;12:57-67. View abstract.
  975. Ghielmini, M., Pagani, O., de Jong, J., Pampallona, S., Conti, A., Maestroni, G., Sessa, C., and Cavalli, F. Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer. Br J Cancer 1999;80:1058-1061. View abstract.
  976. Jan, J. E., Connolly, M. B., Hamilton, D., Freeman, R. D., and Laudon, M. Melatonin treatment of non-epileptic myoclonus in children. Dev.Med Child Neurol. 1999;41:255-259. View abstract.
  977. Shah, J., Langmuir, V., and Gupta, S. K. Feasibility and functionality of OROS melatonin in healthy subjects. J Clin Pharmacol 1999;39:606-612. View abstract.
  978. Kunz, D. and Bes, F. Melatonin as a therapy in REM sleep behavior disorder patients: an open-labeled pilot study on the possible influence of melatonin on REM-sleep regulation. Mov Disord. 1999;14:507-511. View abstract.
  979. Li, X. J., Zhang, L. M., Gu, J., Zhang, A. Z., and Sun, F. Y. Melatonin decreases production of hydroxyl radical during cerebral ischemia-reperfusion. Zhongguo Yao Li Xue.Bao. 1997;18:394-396. View abstract.
  980. Lusardi, P., Preti, P., Savino, S., Piazza, E., Zoppi, A., and Fogari, R. Effect of bedtime melatonin ingestion on blood pressure of normotensive subjects. Blood Press Monit. 1997;2:99-103. View abstract.
  981. Yeleswaram, K., Vachharajani, N., and Santone, K. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications. J Pineal Res 1999;26:190-191. View abstract.
  982. Miyamoto, A., Oki, J., Takahashi, S., and Okuno, A. Serum melatonin kinetics and long-term melatonin treatment for sleep disorders in Rett syndrome. Brain Dev. 1999;21:59-62. View abstract.
  983. Mishima, K., Tozawa, T., Satoh, K., Matsumoto, Y., Hishikawa, Y., and Okawa, M. Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking. Biol Psychiatry 2-15-1999;45:417-421. View abstract.
  984. Rossignol, D. A. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann.Clin Psychiatry 2009;21:213-236. View abstract.
  985. Ferri, C. and Grassi, D. Antioxidants and beneficial microvascular effects: is this the remedy? Hypertension 2010;55:1310-1311. View abstract.
  986. Scott, G. N. and Elmer, G. W. Update on natural product--drug interactions. Am J Health Syst.Pharm 2-15-2002;59:339-347. View abstract.
  987. Mevcha, A., Gulur, D. M., and Gillatt, D. Diagnosing urological disorders in ageing men. Practitioner 2010;254:25-9, 2. View abstract.
  988. Zesiewicz, T. A. and Evatt, M. L. Potential influences of complementary therapy on motor and non-motor complications in Parkinson's disease. CNS.Drugs 10-1-2009;23:817-835. View abstract.
  989. Beaumont, M., Batejat, D., Pierard, C., Van Beers, P., Denis, J. B., Coste, O., Doireau, P., Chauffard, F., French, J., and Lagarde, D. Caffeine or melatonin effects on sleep and sleepiness after rapid eastward transmeridian travel. J.Appl.Physiol 2004;96:50-58. View abstract.
  990. Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. J.Am.Pharm.Assoc. 2010;50:e106-e115. View abstract.
  991. Chaudhary, G., Sharma, U., Jagannathan, N. R., and Gupta, Y. K. Evaluation of Withania somnifera in a middle cerebral artery occlusion model of stroke in rats. Clin Exp.Pharmacol Physiol 2003;30(5-6):399-404. View abstract.
  992. Lee, T. and Dugoua, J. J. Nutritional supplements and their effect on glucose control. Curr.Diab.Rep. 2011;11:142-148. View abstract.
  993. Millan-Plano, S., Piedrafita, E., Miana-Mena, F. J., Fuentes-Broto, L., Martinez-Ballarin, E., Lopez-Pingarron, L., Saenz, M. A., and Garcia, J. J. Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage. Int J Mol.Sci 2010;11:312-328. View abstract.
  994. Mulder H, Nagorny CL, Lyssenko V, et al. Melatonin receptors in pancreatic islets: good morning to a novel type 2diabetes gene. Diabetologia. 2009 Jul;52:1240-9. View abstract.
  995. Mutluay R. Elbeg S. Karakus R. et al. The Impact of Melatonin on Glucose Homeostasis. Turkish Journal of Endocrinology and Metabolism 2009;13:52-55.
  996. Kadhim, HM, Ismail, SH, Hussein, KI, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res 2006;41:189-93. View abstract.
  997. Hussain, SA, Khadim, HM, Khalaf, BH, et al. Effects of melatonin and zinc on glycemic control in type 2 diabetic patients poorly controlled with metformin. Saudi Med J 2006;27:1483-8. View abstract.
  998. Periera Rde S. Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. J Pineal Res 2006;41:195-200. View abstract.
  999. Saha L, Malhotra S, Rana S, et al. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol 2007;41:29-32. View abstract.
  1000. Weiss MD, Wasdell MB, Bomben MM, et al. Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia. J Am Acad Child Adolesc Psychiatry 2006;45:512-9. View abstract.
  1001. Buscemi N, Vandermeer B, Hooton N, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med 2005;20:1151-8. View abstract.
  1002. van Heukelom RO, Prins JB, Smits MG, Bleijenberg G. Influence of melatonin on fatigue severity in patients with chronic fatigue syndrome and late melatonin secretion. Eur J Neurol 2006;13:55-60. View abstract.
  1003. Buscemi N, Vandermeer B, Hooton N, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis. BMJ 2006;332:385-93. View abstract.
  1004. Song GH, Leng PH, Gwee KA, et al. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised double blind placebo controlled study. Gut 2005;54:1402-7. View abstract.
  1005. Buscemi N, Vandermeer B, Pandya R, et al. Melatonin for treatment of sleep disorders. Summary, Evidence Report/Technology Assessment #108. (Prepared by the Univ of Alberta Evidence-based Practice Center, under Contract#290-02-0023.) AHRQ Publ #05-E002-2. Rockville, MD: Agency for Healthcare Research & Quality. November 2004.
  1006. Peres MFP, Zukerman E, da Cunha Tanuri F, et al. Melatonin, 3 mg, is effective for migraine prevention. Neurology 2004;63:757. View abstract.
  1007. Secreto G, Chiechi LM, Amadori A, et al. Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study. Maturitas 2004;47:11-20. View abstract.
  1008. Nagtegaal JE, Smits MG, Swart AC, et al. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache Apr 1998;38:303-7. View abstract.
  1009. Pei Z, Pang SF, Cheung RT. Administration of melatonin after onset of ischemia reduces the volume of cerebral infarction in a rat middle cerebral artery occlusion stroke model. Stroke 2003;34:770-5.. View abstract.
  1010. Lewy AJ, Bauer VK, Cutler NL, Sack RL. Melatonin treatment of winter depression: a pilot study. Psychiatry Res 1998;77:57-61.. View abstract.
  1011. Tjon Pian Gi CV, Broeren JP, Starreveld JS, A Versteegh FG. Melatonin for treatment of sleeping disorders in children with attention deficit/hyperactivity disorder: a preliminary open label study. Eur J Pediatr 2003;162:554-5. View abstract.
  1012. Leman ES, Sisken BF, Zimmer S, Anderson KW. Studies of the interactions between melatonin and 2 Hz, 0.3 mT PEMF on the proliferation and invasion of human breast cancer cells. Bioelectromagnetics 2001;22:178-84.. View abstract.
  1013. Nickelsen T, Lang A, Bergau L. The effect of 6-, 9- and 11-hour time shifts on circadian rhythms: adaptation of sleep parameters and hormonal patterns following the intake of melatonin or placebo. Adv Pineal Res 1991;5:303-6.
  1014. Sener G, Satiroglu H, Kabasakal L, et al. The protective effect of melatonin on cisplatin nephrotoxicity. Fundam Clin Pharmacol 2000;14:553-60.. View abstract.
  1015. Tooley GA, Armstrong SM, Norman TR, Sali A. Acute increases in night-time plasma melatonin levels following a period of meditation. Biol Psychol 2000;53:69-78.. View abstract.
  1016. Nathan PJ, Wyndham EL, Burrows GD, Norman TR. The effect of gender on the melatonin suppression by light: a dose response relationship. J Neural Transm 2000;107:271-9.. View abstract.
  1017. Molina-Carballo A, Munoz-Hoyos A, Reiter RJ, et al. Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. J Pineal Res 1997;23:97-105.. View abstract.
  1018. Fauteck J, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999;8:105-10.. View abstract.
  1019. Stewart LS. Endogenous melatonin and epileptogenesis: facts and hypothesis. Int J Neurosci 2001;107:77-85.. View abstract.
  1020. Williamson BL, Tomlinson AJ, Mishra PK, et al. Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome. Chem Res Toxicol 1998;11:234-40.. View abstract.
  1021. Williamson BL, Tomlinson AJ, Naylor S, Gleich GJ. Contaminants in commercial preparations of melatonin. Mayo Clin Proc 1997;72:1094-5. View abstract.
  1022. Burgess HJ, Sletten T, Savic N, et al. Effects of bright light and melatonin on sleep propensity, temperature, and cardiac activity at night. J Appl Physiol 2001;91:1214-22.. View abstract.
  1023. Cagnacci A, Arangino S, Renzi A, et al. Influence of melatonin administration on glucose tolerance and insulin sensitivity of postmenopausal women. Clin Endocrinol (Oxf) 2001;54:339-46.. View abstract.
  1024. Cuzzocrea S, Reiter RJ. Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury. Eur J Pharmacol 2001;426:1-10.. View abstract.
  1025. Hill SM, Collins A, Kiefer TL. The modulation of oestrogen receptor-alpha activity by melatonin in MCF-7 human breast cancer cells. Eur J Cancer 2000;36(Suppl 4):117-8. View abstract.
  1026. Poeggeler B, Miravalle L, Zagorski MG, et al. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry 2001;40:14995-5001.. View abstract.
  1027. Andrade C, Srihari BS, Reddy KP, Chandramma L. Melatonin in medically ill patients with insomnia: a double-blind, placebo-controlled study. J Clin Psychiatry 2001;62:41-5.. View abstract.
  1028. Smits MG, Nagtegaal EE, van der Heijden J, et al. Melatonin for chronic sleep onset insomnia in children: a randomized placebo-controlled trial. J Child Neurol 2001;16:86-92.. View abstract.
  1029. Dodge NN, Wilson GA. Melatonin for treatment of sleep disorders in children with developmental disabilities. J Child Neurol 2001;16:581-4.. View abstract.
  1030. Stone BM, Turner C, Mills SL, Nicholson AN. Hypnotic activity of melatonin. Sleep 2000;23:663-9.. View abstract.
  1031. Williams G, Waterhouse J, Mugarza J, et al. Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. Eur J Clin Invest 2002;32:831-7.. View abstract.
  1032. Cagnacci A, Zanni AL, Veneri MG, et al. Influence of exogenous melatonin on catecholamine levels in postmenopausal women prior and during oestradiol replacement. Clin Endocrinol (Oxf) 2000;53:367-72.. View abstract.
  1033. Golombek DA, Escolar E, Burin LJ, et al. Chronopharmacology of melatonin: inhibition by benzodiazepine antagonism. Chronobiol Int 1992;9:124-31.. View abstract.
  1034. Pringsheim T, Magnoux E, Dobson CF, et al. Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. Headache 2002;42:787-92.. View abstract.
  1035. Citera G, Arias MA, Maldonado-Cocco JA, et al. The effect of melatonin in patients with fibromyalgia: a pilot study. Clin Rheumatol 2000;19:9-13.. View abstract.
  1036. Papezova H, Yamamotova A, Nedvidkova J. Pain modulation role of melatonin in eating disorders. Eur Psychiatry 2001;16:68-70.. View abstract.
  1037. Peled N, Shorer Z, Peled E, Pillar G. Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia 2001;42:1208-10.. View abstract.
  1038. Sandyk R. Melatonin and petit-mal epilepsy: an hypothesis. Int J Neurosci 1992;65:83-90.. View abstract.
  1039. Sandyk R, Tsagas N, Anninos PA. Melatonin as a proconvulsive hormone in humans. Int J Neurosci 1992;63:125-35.. View abstract.
  1040. Schapel GJ, Beran RG, Kennaway DL, et al. Melatonin response in active epilepsy. Epilepsia 1995;36:75-8.. View abstract.
  1041. Munoz-Hoyos A, Sanchez-Forte M, Molina-Carballo A, et al. Melatonin's role as an anticonvulsant and neuronal protector: experimental and clinical evidence. J Child Neurol 1998;13:501-9.. View abstract.
  1042. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev 2002;2:CD001520.. View abstract.
  1043. Lewy AJ, Ahmed S, Jackson JM, Sack RL. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int 1992;9:380-92. View abstract.
  1044. Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998;15:655-66. View abstract.
  1045. Nishiyama K, Yasue H, Moriyama Y, et al. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Am Heart J 2001;141:E9. View abstract.
  1046. Briggs, Freeman, Yafee. Update Drugs in Pregnancy and Lactation. Lippincott Williams & Wilkins, 2001.
  1047. Djeridane Y, Touitou Y. Chronic diazepam administration differentially affects melatonin synthesis in rat pineal and Harderian glands. Psychopharmacology (Berl) 2001;154:403-7. View abstract.
  1048. Herxheimer A, Petrie KJ. Melatonin for preventing and treating jet lag. Cochrane Database Syst Rev 2001;:CD001520. View abstract.
  1049. Lissoni P, Paolorossi F, Ardizzoia A, et al. A randomized study of chemotherapy with cisplatin plus etoposide versus chemoendocrine therapy with cisplatin, etoposide and the pineal hormone melatonin as a first-line treatment of advanced non-small cell lung cancer patients in a poor clinical state. J Pineal Res 1997;23:15-9. View abstract.
  1050. Naylor S, Gleich GJ. Over-the-counter melatonin products and contamination. Am Fam Physician 1999;59:284, 287-8. View abstract.
  1051. Wright KP Jr, Myers BL, Plenzler SC, et al. Acute effects of bright light and caffeine on nighttime melatonin and temperature levels in women taking and not taking oral contraceptives. Brain Res 2000;873:310-7. View abstract.
  1052. Wurtman RJ. Age-related decreases in melatonin secretion--clinical consequences. J Clin Endocrinol Metab 2000;85:2135-6. View abstract.
  1053. Sivan Y, Laudon M, Kuint J, Zisapel N. Low melatonin production in infants with a life-threatening event. Dev Med Child Neurol 2000;42:487-91. View abstract.
  1054. Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67:1-6. View abstract.
  1055. Bazil CW, Short D, Crispin D, Zheng W. Patients with intractable epilepsy have low melatonin, which increases following seizures. Neurology 2000;55:1746-8. View abstract.
  1056. Sheldon SH. Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 1998;351:1254. View abstract.
  1057. Mishima K, Okawa M, Shimizu T, Hishikawa Y. Diminished melatonin secretion in the elderly caused by insufficient environmental illumination. J Clin Endocrinol Metab 2001;86:129-34. View abstract.
  1058. Salti R, Galluzzi F, Bindi G, et al. Nocturnal melatonin patterns in children. J Clin Endocrinol Metab 2000;85:2137-44. View abstract.
  1059. Shamir E, Laudon M, Barak Y, et al. Melatonin improves sleep quality of patients with chronic schizophrenia. J Clin Psychiatry 2000;61:373-7. View abstract.
  1060. Nagtegaal JE, Laurant MW, Kerkhof GA, et al. Effects of melatonin on the quality of life in patients with delayed sleep phase syndrome. J Psychosom Res 2000;48:45-50. View abstract.
  1061. Kumar AM, Tims F, Cruess DG, et al. Music therapy increases serum melatonin levels in patients with Alzheimer's disease. Altern Ther Health Med 1999;5:49-57. View abstract.
  1062. Shilo L, Dagan Y, Smorjik Y, et al. Effect of melatonin on sleep quality of COPD intensive care patients: a pilot study. Chronobiol Int 2000;17:71-6. View abstract.
  1063. Kovacs J, Brodner W, Kirchlechner V, et al. Measurement of urinary melatonin: a useful tool for monitoring serum melatonin after its oral administration. J Clin Endocrinol Metab 2000;85:666-70. View abstract.
  1064. Jones MP, Melan MA, Witt-Enderby PA. Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner. Cancer Lett 2000;151:133-43. View abstract.
  1065. Lissoni P, Cazzaniga M, Tancini G, et al. Reversal of clinical resistance to LHRH analogue in metastatic prostate cancer by the pineal hormone melatonin: efficacy of LHRH analogue plus melatonin in patients progressing on LHRH analogue alone. Eur Urol 1997;31:178-81. View abstract.
  1066. Shamir E, Barak Y, Shalman I, et al. Melatonin treatment for tardive dyskinesia: A double-blind, placebo-controlled, crossover study. Arch Gen Psychiatry 2001;58:1049-52. View abstract.
  1067. Zhdanova IV, Wurtman RJ, Regan MM, et al. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab 2001;86:4727-30. View abstract.
  1068. Lissoni P, Barni S, Meregalli S, et al. Modulation of cancer endocrine therapy by melatonin: a phase II study of tamoxifen plus melatonin in metastatic breast cancer patients progressing under tamoxifen alone. Br J Cancer 1995;71:854-6. View abstract.
  1069. Erren TC, Piekarski C. Does winter darkness in the arctic protect against cancer? The melatonin hypothesis revisited. Med Hypotheses 1999;53:1-5. View abstract.
  1070. Kliukiene J, Tynes T, Andersen A. Risk of breast cancer among Norwegian women with visual impairment. Br J Cancer 2001;84:397-9. View abstract.
  1071. Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solic tumor patients with poor clinical status. Eur J Cancer 1999;35:1688-92. View abstract.
  1072. Brun J, Claustrat B, Saddier P, Chazot G. Nocturnal melatonin excretion is decreased in patients with migraine without aura attacks associated with menses. Cephalalgia 1995;15:136-9. View abstract.
  1073. Sack RL, Brandes RW, Kendall AR, et al. Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 2000;343:1070-7. View abstract.
  1074. Grozinger M, Hartter S, Wang X, et al. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile. Arch Gen Psychiatry 2000 Aug;57:812-3. View abstract.
  1075. von Bahr C, Ursing C, Yasui N, et al. Fluvoxamine but not citalopram increases serum melatonin in healthy subjects – an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol 2000;56:123-7. View abstract.
  1076. Drago F, Busa L. Acute low doses of melatonin restore full sexual activity in impotent male rats. Brain Res 2000;878:98-104. View abstract.
  1077. Spitzer RL, Terman M, Williams JBW, et al. Jet lag: Clinical features, validation of a new syndrome-specific scale, lack of response to melatonin in a randomized, double-blind trial. Am J Psychiatry 1999;156:1392-6. View abstract.
  1078. Lusardi P, et al. Cardiovascular effects of melatonin in hypertensive patients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol 2000;49:423-7. View abstract.
  1079. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  1080. Lissoni P, Paolorossi F, Tancini G, et al. A phase II study of tamoxifen plus melatonin in metastatic solid tumour patients. Br J Cancer 1996;74:1466-8. View abstract.
  1081. Bubis M, Zisapel N. Modulation by melatonin of protein secretion from melanoma cells: is cAMP involved? Molecular and Cellular Endocrinology 1995;112:169-73. View abstract.
  1082. Lissoni P, Barni S, Tancini G, et al. A randomised study with subcutaneous low-dose interleukin 2 alone vs. interleukin 2 plus the pineal neurohormone melatonin in advanced solid neoplasms other than renal cancer and melanoma. Br J Cancer 1994;69:196-9. View abstract.
  1083. Lissoni P, Barni S, Cazzaniga M, et al. Efficacy of the concomitant administration of the pineal hormone melatonin in cancer immunotherapy with low-dose IL-2 in patients with advanced solid tumors who had progressed on Il-2 alone. Oncology 1994;51:344-7. View abstract.
  1084. Hartter S, Grozinger M, Weigmann H, et al. Increased bioavailability of oral melatonin after fluvoxamine coadministration. Clin Pharmacol Ther 2000;67:1-6. View abstract.
  1085. Dreher F, Denig N, Gabard B, et al. Effect of topical antioxidants on UV-induced erythema formation when administered after exposure. Dermatol 1999;198:52-5. View abstract.
  1086. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol 1998;139:332-9. View abstract.
  1087. Roth JA, Kim B-G, Lin W-L, et al. Melatonin promotes osteoblast differentiation and bone formation. J Biol Chem 1999;274:22041-7. View abstract.
  1088. Lissoni P. Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms. Ann N Y Acad Sci 2000;917:560-7. View abstract.
  1089. Lissoni P, Giani L, Zerbini S, et al. Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus Aloe vera in untreatable advanced solid neoplasms. Nat Immun 1998;16:27-33. View abstract.
  1090. Lissoni P, Bucovec R, Bonfanti A, et al. Thrombopoietic properties of 5-methoxytryptamine plus melatonin versus melatonin alone in the treatment of cancer-related thrombocytopenia. J Pineal Res 2001;30:123-6. View abstract.
  1091. Lissoni P, Tancini G, Barni S, et al. Treatment of cancer chemotherapy-induced toxicity with the pineal hormone melatonin. Support Care Cancer 1997;5:126-9. View abstract.
  1092. Bellipanni G, Bianchi P, Pierpaoli W, et al. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Exp Gerontol 2001;36:297-310. View abstract.
  1093. Zhdanova IV, Piotrovskaya VR. Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans. Pharmacol Biochem Behavior 2000;67:131-5. View abstract.
  1094. Zeitzer JM, Daniels JE, Duffy JF, et al. Do plasma melatonin concentrations decline with age? Am J Med 1999;107:432-6. View abstract.
  1095. Stoschitzky K, Sakotnik A, Lercher P, et al. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol 1999;55:111-5. View abstract.
  1096. Forsling ML, Wheeler MJ, Williams AJ. The effect of melatonin administration on pituitary hormone secretion in man. Clin Endocrinol (Oxf) 1999;51:637-42. View abstract.
  1097. Ebadi M, Govitrapong P, Phansuwan-Pujito P, et al. Pineal opioid receptors and analgesic action of melatonin. J Pineal Res 1998;24:193-200. View abstract.
  1098. Meeking DR, Wallace JD, Cuneo RC, et al. Exercise-induced GH secretion is enhanced by the oral ingestion of melatonin in healthy adult male subjects. Eur J Endocrinol 1999;141:22-6. View abstract.
  1099. Fraschini F, Cesarani A, Alpini D, et al. Melatonin influences human balance. Biol Signals Recept 1999;8:111-9. View abstract.
  1100. Nathan PJ, Burrows GD, Norman TR. The effect of age and pre-light melatonin concentration on the melatonin sensitivity to dim light. Int Clin Psychopharmacol 1999;14:189-92. View abstract.
  1101. Arendt J. Melatonin. BMJ 1996;312:1242-3. View abstract.
  1102. Brzezinski A. Melatonin in humans. N Engl J Med 1997;336:186-95. View abstract.
  1103. Avery D, Lenz M, Landis C. Guidelines for prescribing melatonin. Ann Med 1998;30:122-30. View abstract.
  1104. Jan JE, Freeman RD, Fast DK. Melatonin treatment of sleep-wake cycle disorders in children and adolescents. Dev Med Child Neurol 1999;41:491-500. View abstract.
  1105. Naguib M, Samarkandi AH. Premedication with melatonin: a double-blind, placebo-controlled comparison with midazolam. Br J Anaesth 1999;82:875-80. View abstract.
  1106. Fischer T, Bangha E, Elsner P, et al. Suppression of UV-induced erythema by topical treatment with melatonin. Influence of the application time point. Biol Signals Recept 1999;8:132-5. View abstract.
  1107. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). Influence of the application time point. Dermatology 1997;195:248-52. View abstract.
  1108. Leibenluft E, Feldman-Naim S, Turner EH, et al. Effects of exogenous melatonin administration and withdrawal in five patients with rapid-cycling bipolar disorder. J Clin Psychiatry 1997;58:383-8. View abstract.
  1109. Carman JS, Post RM, Buswell R, et al. Negative effects of melatonin on depression. Am J Psychiatry 1976;133:1181-1186. View abstract.
  1110. Zhdanova IV, Wurtman RJ, Morabito C, et al. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep 1996;19:423-31. View abstract.
  1111. Nave R, Peled R, Lavie P. Melatonin improves evening napping. Eur J Pharmacol 1995;275:213-6. View abstract.
  1112. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552-8. View abstract.
  1113. Dollins AB, Zhdanova IV, Wurtman RJ, et al. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 1994;91:1824-8. View abstract.
  1114. Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346:541-4. View abstract.
  1115. Waldhauser F, Saletu B, Trinchard-Lugan I. Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology (Berl) 1990;100:222-6. View abstract.
  1116. Dagan Y, Zisapel N, Nof D, et al. Rapid reversal of tolerance to benzodiazepine hypnotics by treatment with oral melatonin: a case report. Eur Neuropsychopharmacol 1997;7:157-60. View abstract.
  1117. Skene DJ, Lockley SW, Arendt J. Melatonin in circadian sleep disorders in the blind. Biol Signals Recept 1999;8:90-5. View abstract.
  1118. O'Callaghan FJ, Clarke AA, Hancock E, et al. Use of melatonin to treat sleep disorders in tuberous sclerosis. Dev Med Child Neurol 1999;41:123-6. View abstract.
  1119. Jan JE, O'Donnell ME. Use of melatonin in the treatment of paediatric sleep disorders. J Pineal Res 1996;21:193-9. View abstract.
  1120. Lancioni GE, O'Reilly MF, Basili G. Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps. Am J Ment Retard 1999;104:170-86. View abstract.
  1121. Palm L, Blennow G, Wetterberg L. Long-term melatonin treatment in blind children and young adults with circadian sleep-wake disturbances. Dev Med Child Neurol 1997;39:319-25. View abstract.
  1122. Commentz JC, Uhlig H, Henke A, et al. Melatonin and 6-hydroxymelatonin sulfate excretion is inversely correlated with gonadal development in children. Horm Res 1997;47:97-101. View abstract.
  1123. Cavallo A, Ritschel WA. Pharmacokinetics of melatonin in human sexual maturation. J Clin Endocrinol Metab 1996;81:1882-6. View abstract.
  1124. Nordlund JJ, Lerner AB. The effects of oral melatonin on skin color and on the release of pituitary hormones. J Clin Endocrinol Metab 1977;45:768-74. View abstract.
  1125. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  1126. Luboshitzky R, Wagner O, Lavi S, et al. Abnormal melatonin secretion in hypogonadal men: the effect of testosterone treatment. Clin Endocrinol (Oxf) 1997;47:463-9. View abstract.
  1127. Haimov I, Lavie P, Laudon M, et al. Melatonin replacement therapy of elderly insomniacs. Sleep 1995;18:598-603. View abstract.
  1128. Brusco LI, Fainstein I, Marquez M, Cardinali DP. Effect of melatonin in selected populations of sleep-disturbed patients. Biol Signals Recept 1999;8:126-31. View abstract.
  1129. Brusco LI, Marquez M, Cardinali DP. Monozygotic twins with Alzheimer's disease treated with melatonin: Case report. J Pineal Res 1998;25:260-3. View abstract.
  1130. Arangino S, Cagnacci A, Angiolucci M, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 1999;83:1417-9. View abstract.
  1131. Sanders DC, Chaturvedi AK, Hordinsky JR. Melatonin: aeromedical, toxicopharmacological, and analytical aspects. J Anal Toxicol 1999;23:159-67. View abstract.
  1132. Jorgensen KM, Witting MD. Does exogenous melatonin improve day sleep or night alertness in emergency physicians working night shifts? Ann Emerg Med 1998;31:699-704. View abstract.
  1133. Fauteck J, Schmidt H, Lerchl A, et al. Melatonin in epilepsy: first results of replacement therapy and first clinical results. Biol Signals Recept 1999;8:105-10. View abstract.
  1134. Bregani ER, Lissoni P, Rossini F, et al. Prevention of interleukin-2-induced thrombocytopenia during the immunotherapy of cancer by a concomitant administration of the pineal hormone melatonin. Recenti Prog Med 1995;86:231-3. View abstract.
  1135. Lissoni P, Barni S, Brivio F, et al. A biological study on the efficacy of low-dose subcutaneous interleukin-2 plus melatonin in the treatment of cancer-related thrombocytopenia. Oncology 1995;52:360-2. View abstract.
  1136. Lissoni P, Tancini G, Barni S, et al. The pineal hormone melatonin in hematology and its potential efficacy in the treatment of thrombocytopenia. Recenti Prog Med 1996;87:582-5. View abstract.
  1137. Lissoni P, Tancini G, Paolorossi F, et al. Chemoneuroendocrine therapy of metastatic breast cancer with persistent thrombocytopenia with weekly low-dose epirubicin plus melatonin: a phase II study. J Pineal Res 1999;26:169-73. View abstract.
  1138. Lissoni P, Barni S, Ardizzoia A, et al. A randomized study with the pineal hormone melatonin versus supportive care alone in patients with brain metastases due to solid neoplasms. Cancer 1994;73:699-701. View abstract.
  1139. Lissoni P, Tisi E, Barni S, et al. Biological and clinical results of a neuroimmunotherapy with interleukin-2 and the pineal hormone melatonin as a first line treatment in advanced non-small cell lung cancer. Br J Cancer 1992;66:155-8. View abstract.
  1140. FDA. List of orphan designations and approvals. Office of Orphan Products Development. Available at:
  1141. Claustrat B, Brun J, Geoffriau M, et al. Nocturnal plasma melatonin profile and melatonin kinetics during infusion in status migrainosus. Cephalalgia 1997;17:511-7;487. View abstract.
  1142. Lissoni P, Barni S, Cattaneo G, et al. Clinical results with the pineal hormone melatonin in advanced cancer resistant to standard antitumor therapies. Oncology 1991;48:448-50. View abstract.
  1143. Bertino JS, Demuro RL, Blask DE, et al. Absolute bioavailability (F) of oral melatonin (M). Clin Pharmacol Ther 2000;67:106 (abstract PI-72).
  1144. Cagnacci A, Krauchi K, Wirz-Justice A, Volpe A. Homeostatic versus circadian effects of melatonin on core body temperature in humans. J Biol Rhythms 1997;12:509-17. View abstract.
  1145. Blau JN, Engel HO. A new cluster headache precipitant: increased body heat. Lancet 1999;354:1001-2. View abstract.
  1146. Peres MF, Seabra ML, Zukerman E, Tufik S. Cluster headache and melatonin. Lancet 2000;355:147. View abstract.
  1147. Leone M, D'Amico D, Moschiano F, et al. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996;16:494-6. View abstract.
  1148. DeMuro RL, Nafziger AN, Blask DE, et al. The absolute bioavailability of oral melatonin. J Clin Pharmacol 2000;40:781-4. View abstract.
  1149. Naguib M, Samarkandi AH. The comparative dose-response effects of melatonin and midazolam for premedication of adult patients: a double-blinded, placebo-controlled study. Anesth Analg 2000;91:473-9. View abstract.
  1150. Nurnberger JI Jr, Adkins S, Lahiri DK, et al. Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch Gen Psychiatr 2000;57:572-9. View abstract.
  1151. Petrie K, Conaglen JV, Thompson L, Chamberlain K. Effect of melatonin on jet lag after long haul flights. BMJ 1989;298:705-7. View abstract.
  1152. James SP, Sack DA, Rosenthal NE, Mendelson WB. Melatonin administration in insomnia. Neuropsychopharmacology 1990;3:19-23. View abstract.
  1153. Sack RL, Lewy AJ, Blood ML, et al. Melatonin administration to blind people: phase advances and entrainment. J Biol Rhythms 1991;6:249-61. View abstract.
  1154. Dahlitz M, Alvarez B, Vignau J, et al. Delayed sleep phase syndrome response to melatonin. Lancet 1991;337:1121-4. View abstract.
  1155. Lissoni P, Barni S, Ardizzoia A, et al. Randomized study with the pineal hormone melatonin versus supportive care alone in advanced nonsmall cell lung cancer resistant to a first-line chemotherapy containing cisplatin. Oncology 1992;49:336-9. View abstract.
  1156. Claustrat B, Brun J, David M, et al. Melatonin and jet lag: confirmatory result using a simplified protocol. Biol Psychiatr 1992;32:705-11. View abstract.
  1157. Dollins AB, Lynch HJ, Wurtman RJ, et al. Effect of pharmacological daytime doses of melatonin on human mood and performance. Psychopharmacol (Berl) 1993;112:490-6. View abstract.
  1158. Petrie K, Dawson AG, Thompson L, Brook R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatr 1993;33:526-30. View abstract.
  1159. Valcavi R, Zini M, Maestroni GJ, et al. Melatonin stimulates growth hormone secretion through pathways other than the growth hormone-releasing hormone. Clin Endocrinol (Oxf) 1993;39:193-9. View abstract.
  1160. Garfinkel D, et al. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346:541-44. View abstract.
  1161. Ellis CM, Lemmens G, Parkes JD. Melatonin and insomnia. J Sleep Res 1996;5:61-5. View abstract.
  1162. Lissoni P, Pittalis S, Ardizzoia A, et al. Prevention of cytokine-induced hypotension in cancer patients by the pineal hormone melatonin. Support Care Cancer 1996;4:313-6. View abstract.
  1163. Attenburrow ME, Cowen PJ, Sharpley AL. Low dose melatonin improves sleep in healthy middle-aged subjects. Psychopharmacol (Berl) 1996;126:179-81. View abstract.
  1164. Bangha E, Elsner P, Kistler GS. Suppression of UV-induced erythema by topical treatment with melatonin (N-acetyl-5-methoxytryptamine). A dose response study. Arch Dermatol Res 1996;288:522-6. View abstract.
  1165. Lissoni P, Brivio O, Brivio F, et al. Adjuvant therapy with the pineal hormone melatonin in patients with lymph node relapse due to malignant melanoma. J Pineal Res 1996;21:239-42. View abstract.
  1166. Wikner J, Wetterberg L, Rojdmark S. Does hypercalcaemia or calcium antagonism affect human melatonin secretion or renal excretion? Eur J Clin Invest 1997;27:374-9. View abstract.
  1167. Van Den Heuvel CJ, Reid KJ, Dawson D. Effect of atenolol on nocturnal sleep and temperature in young men: reversal by pharmacological doses of melatonin. Physiol Behav 1997;61:795-802. View abstract.
  1168. Benes L, Claustrat B, Horriere F, et al. Transmucosal, oral controlled-release, and transdermal drug administration in human subjects: a crossover study with melatonin. J Pharm Sci 1997;86:1115-9. View abstract.
  1169. McArthur AJ, Budden S. Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment. Dev Med Child Neurol 1998;40:186-92. View abstract.
  1170. James M, Tremea MO, Jones JS, Krohmer JR. Can melatonin improve adaptation to night shift? Am J Emerg Med 1998;16:367-70. View abstract.
  1171. Dolberg OT, Hirschmann S, Grunhaus L. Melatonin for the treatment of sleep disturbances in major depressive disorder. Am J Psychiatr 1998;155:1119-21. View abstract.
  1172. Wright SW, Lawrence LM, Wrenn KD, et al. Randomized clinical trial of melatonin after night-shift work: efficacy and neuropsychologic effects. Ann Emerg Med 1998 32(3 Pt 1):334-40. View abstract.
  1173. Suhner A, Schlagenhauf P, Johnson R, et al. Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 1998;15:655-6. View abstract.
  1174. Voordouw BC, Euser R, Verdonk RE, et al. Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol Metab 1992;74:108-17. View abstract.
  1175. Garfinkel D, Zisapel N, Wainstein J, Laudon M. Facilitation of benzodiazepine discontinuation by melatonin, a new clinical approach. Arch Intern Med 1999;159:2456-60. View abstract.
  1176. Wiid I, Hoal-van Helden E, Hon D, et al. Potentiation of isoniazid activity against Mycobacterium tuberculosis by melatonin. Antimicrob Agents Chemother 1999;43:975-7. View abstract.
  1177. Wagner J, Wagner ML, Hening WA. Beyond benzodiazepines: alternative pharmacologic agents for the treatment of insomnia. Ann Pharmacother 1998;32:680-91. View abstract.
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Last reviewed - 06/20/2014

Page last updated: 08 September 2014