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Green tea

What is it?

Green tea is a product made from the Camellia sinensis plant. It can be prepared as a beverage, which can have some health effects. Or an “extract” can be made from the leaves to use as medicine.

Green tea is used to improve mental alertness and thinking.

It is also used for weight loss and to treat stomach disorders, vomiting, diarrhea, headaches, bone loss (osteoporosis), and solid tumor cancers.

Some people use green tea to prevent various cancers, including breast cancer, prostate cancer, colon cancer, gastric cancer, lung cancer, solid tumor cancers and skin cancer related to exposure to sunlight. Some women use green tea to fight human papilloma virus (HPV), which can cause genital warts, the growth of abnormal cells in the cervix (cervical dysplasia), and cervical cancer.

Green tea is also used for Crohn’s disease, Parkinson’s disease, diseases of the heart and blood vessels, diabetes, low blood pressure, chronic fatigue syndrome (CFS), dental cavities (caries), kidney stones, and skin damage.

Instead of drinking green tea, some people apply green tea bags to their skin to soothe sunburn and prevent skin cancer due to sun exposure. Green tea bags are also used to decrease puffiness under the eyes, as a compress for tired eyes or headache, and to stop gums from bleeding after a tooth is pulled.

Green tea in candy is used for gum disease.

Green tea is used in an ointment for genital warts. Do not confuse green tea with oolong tea or black tea. Oolong tea and black tea are made from the same plant leaves used to make green tea, but they are prepared differently and have different medicinal effects. Green tea is not fermented at all. Oolong tea is partially fermented, and black tea is fully fermented.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for GREEN TEA are as follows:

Likely effective for...

  • Genital warts. A specific green tea extract ointment (Veregen, Bradley Pharmaceuticals) is FDA-approved for treating genital warts.
  • High cholesterol. Taking green tea by mouth seems to lower cholesterol levels. Research suggests that consuming 145-3000 mg of green tea catechins, an antioxidants found in green tea, daily for up to 24 weeks reduces total cholesterol and low-density lipoprotein (LDL or “bad”) cholesterol.
  • Mental alertness. Drinking green tea and other caffeinated beverages seems to help people maintain mental alertness throughout the day. Combining caffeine with sugar as an “energy drink” seems to improve mental performance more than caffeine or sugar alone. Also, taking a combination of green tea extract and L-theanine for seems to improve memory and attention in people with mild mental problems.

Possibly effective for...

  • Abnormal development of cells of the cervix (cervical dysplasia). Taking green tea by mouth or applying it to the skin seems to reduce cervical dysplasia caused by human papilloma virus (HPV) infection.
  • Clogged arteries (coronary artery disease). Population studies suggest that drinking green tea is linked to a reduced risk of clogged arteries. The link seems to be stronger in men than women.
  • Endometrial cancer. Population studies suggest that drinking green tea is linked to a reduced risk of developing endometrial cancer.
  • Low blood pressure. Drinking green tea might help increase blood pressure in elderly people who have low blood pressure after eating.
  • Thick, white patches on the gums (oral leukoplakia). Drinking green tea seems to decrease the size of white patches in people with oral leukoplakia.
  • Osteoporosis. Research suggests that drinking green tea for 10 years is linked to increased bone mineral density. Also, early research suggests that taking a green tea compound containing 500 mg of catechins, an antioxidant in green tea, daily for 24 weeks improves bone strength in post-menopausal women with low bone density.
  • Ovarian cancer. Women who regularly drink tea, including green or black tea, appear to have a lower risk of developing ovarian cancer.
  • Parkinson’s disease. Drinking one to four cups of green tea daily seems to provide the most protection against developing Parkinson’s disease.

Insufficient evidence to rate effectiveness for...

  • Acne. Early research suggests that applying a solution containing a certain chemical found in green tea to the skin for 8 weeks reduces acne.
  • Abnormal protein buildup in the organs (Amyloidosis). Early research suggests that drinking green tea or taking green tea extracts for 12 months protects against an increase in heart mass in people with amyloidosis affecting the heart.
  • Athletic performance. There is inconsistent evidence about the effects of green tea on athletic performance. Some early research suggests that taking green tea extract as a beverage does not improve breathing or performance in people undergoing endurance training. However, other early research suggests that taking seven doses of a certain green tea chemical over three days improves some breathing tests in healthy adults.
  • Bladder cancer, esophadeal cancer, and pancreatic cancer. Most evidence suggests that drinking green tea is linked to a lower risk of bladder, esophageal, and pancreatic cancer. However, there is also some inconsistent evidence that suggests it might not reduce the risk of developing these cancers.
  • Breast cancer. Research suggests that green tea does not seem to reduce the risk of breast cancer in Asian people. However, there is some evidence that it might reduce the risk in Asian-Americans.
  • Heart disease. Population studies suggest that drinking three or more cups of green tea daily is linked to a decreased risk of death from heart disease or any cause.
  • Colds and flu. Early research suggests that taking a specific formulation of green tea and theanine (Thea-flan and Suntheanine) daily for 5 months lowers the risk of developing the flu. Other early research suggests that taking a specific green tea product (ImmuneGuard) reduces cold and flu symptoms and the duration of illness.
  • Colon cancer. Most evidence suggests that drinking green tea does not have any effect on colon cancer risk. However, some research suggests that consuming a high amount is linked to a reduce risk, particularly in women.
  • Diabetes. Research suggests that Japanese adults, particularly women, who drink 6 or more cups of green tea daily, have a lower risk of developing diabetes. However, green tea extract does not seem to help control sugar or insulin levels in people who already have diabetes.
  • Fertility. Early research suggests that taking a specific product containing chasteberry, green tea, L-arginine, vitamins and minerals (FertilityBlend) increases pregnancy rates in women who have trouble conceiving.
  • Stomach cancer. There is inconsistent evidence about the effects of green tea on stomach cancer risk. One study suggests that drinking at least 5 cups of green tea daily does not reduce the risk of stomach cancer. Other research suggests that drinking at least 10 cups of green tea daily reduces the risk of stomach cancer.
  • High blood pressure. There is inconsistent evidence about the effects of green tea on blood pressure. Some research shows that drinking green tea regularly can lower the risk of developing high blood pressure. However, other research shows that it has no effect on blood pressure in people with or without high blood pressure.
  • Allergy to Japanese cedar (pollinosis). Early research suggests that drinking a green tea drink daily for 6 weeks before being exposed to Japanese cedar pollen can reduce allergy symptoms, including throat pain, nose blowing and tears.
  • Leukemia. Population research suggests that Taiwanese people who drink higher amounts of green tea have a lower risk of developing leukemia.
  • Lung cancer. There is inconsistent evidence about the effects of green tea on lung cancer risk. One study suggests that drinking at least 5 cups of green tea daily does not reduce the risk of death related to lung cancer. However, men who consume high amounts of phytoestrogens, chemicals found in green tea, have a lower risk of developing lung cancer.
  • Metabolic syndrome. Early research suggests that taking 1000 mg of green tea extract daily or drinking four cups of green tea daily for 8 weeks does not improve blood pressure, cholesterol levels, or blood sugar in obese people with metabolic syndrome.
  • Obesity. There is inconsistent evidence on the effects of green tea in obese people. Some early research shows that some specific green tea extracts (AR25, Exolise; Sunphenon) reduce weight in people with obesity. Other research suggests that drinking green tea can reduce body weight and body mass index (BMI) in overweight people. However some research suggests that taking green tea extracts or drinking green tea does not reduce body weight or BMI.
  • Mouth cancer. Early research suggests that taking green tea extract three times daily after meals for 12 weeks increases healing responses in people with oral cancer.
  • Gum disease (periodontal disease). Chewing candy that contains green tea extract seems to control plaque build-up on the teeth and reduce gum swelling. Also population research suggests that drinking green tea is linked with a reduced risk of gum disease.
  • Pneumonia. Research suggests that Japanese women who drink green tea have a lower risk of death from pneumonia compared to those who don’t drink green tea.
  • Prostate cancer. Men who drink more green tea or who take products containing green tea antioxidants seem to have a lower risk of developing prostate cancer. However, green tea or green tea extracts do not seem to slow the progression of prostate cancer that has already been diagnosed.
  • Stress. Early research suggests that taking a specific brand of green tea extract (Teavigo) by mouth for 7 days reduces stress and increases calmness.
  • Stroke. According to one study in Japan, drinking 3 cups of green tea daily seems to lower the risk of having a stroke compared to drinking one cup or no tea.
  • Upper respiratory tract infection. Early research suggests that gargling and swallowing green tea (Morgentau) over 4 days is less effective than citrus lozenges (Cystus052) for reducing symptoms of upper respiratory tract infections.
  • Wrinkled skin. Some early research suggests that taking green tea antioxidants twice daily for 2 years does not reduce the signs of sun damage to the face in women. However, applying a green tea cream and taking green tea by mouth daily seems to improve some aspects of skin aging in women.
  • Other conditions.
More evidence is needed to rate green tea for these uses.

How does it work?

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The useful parts of green tea are the leaf bud, leaf, and stem. Green tea is not fermented and is produced by steaming fresh leaves at high temperatures. During this process, it is able to maintain important molecules called polyphenols, which seem to be responsible for many of the benefits of green tea.

Polyphenols might be able to prevent inflammation and swelling, protect cartilage between the bones, and lessen joint degeneration. They also seem to be able to fight human papilloma virus (HPV) infections and reduce the growth of abnormal cells in the cervix (cervical dysplasia). Research cannot yet explain how this works.

Green tea contains 2% to 4% caffeine, which affects thinking and alertness, increases urine output, and may improve the function of brain messengers important in Parkinson’s disease. Caffeine is thought to stimulate the nervous system, heart, and muscles by increasing the release of certain chemicals in the brain called “neurotransmitters.”

Antioxidants and other substances in green tea might help protect the heart and blood vessels.

Are there safety concerns?

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Green tea is LIKELY SAFE for most adults when consumed in moderate amounts. Green tea extract is POSSIBLY SAFE for most people when taken by mouth or applied to the skin for a short time. In some people, green tea can cause stomach upset and constipation. Green tea extracts have been reported to cause liver problems in rare cases.

Drinking too much green tea — more than five cups per day, for example — is POSSIBLY UNSAFE. It can cause side effects because of the caffeine. These side effects can range from mild to serious and include headache, nervousness, sleep problems, vomiting, diarrhea, irritability, irregular heartbeat, tremor, heartburn, dizziness, ringing in the ears, convulsions, and confusion. Green tea seems to reduce the absorption of iron from food. Drinking very high doses of green tea is LIKELY UNSAFE and can actually be fatal. The fatal dose of caffeine in green tea is estimated to be 10-14 grams (150-200 mg per kilogram). Serious toxicity can occur at lower doses.

Caffeine is POSSIBLY SAFE in children in amounts commonly found in foods.

Green tea interacts with many medications, as explained below.

Special precautions & warnings:

Pregnancy and breast-feeding: If you are pregnant or breast-feeding, green tea in small amounts – about 2 cups per day – is POSSIBLY SAFE. This amount of green tea provides about 200 mg of caffeine. However, drinking more than 2 cups of green tea per day is POSSIBLY UNSAFE. Consuming more than 2 cups of green tea daily has been linked to an increased risk of miscarriage and other negative effects. Also, caffeine passes into breast milk and can affect a nursing infant. Don’t drink an excessive amount of green tea if you are pregnant or breast-feeding.

“Tired blood” (anemia): Drinking green tea may make anemia worse.

Anxiety disorders: The caffeine in green tea might make anxiety worse.

Bleeding disorders: Caffeine in green tea might increase the risk of bleeding. Don’t drink green tea if you have a bleeding disorder.

Heart conditions: Caffeine in green tea might cause irregular heartbeat.

Diabetes: Caffeine in green tea might affect blood sugar control. If you drink green tea and have diabetes, monitor your blood sugar carefully.

Diarrhea. Green tea contains caffeine. The caffeine in green tea, especially when taken in large amounts, can worsen diarrhea.

Irritable bowel syndrome (IBS): Green tea contains caffeine. The caffeine in green tea, especially when taken in large amounts, can worsen diarrhea and might worsen symptoms of IBS.

Glaucoma: Drinking green tea increases pressure inside the eye. The increase occurs within 30 minutes and lasts for at least 90 minutes.

High blood pressure: The caffeine in green tea might increase blood pressure in people with high blood pressure. However, this does not seem to occur in people who regularly drink green tea or other products that contain caffeine.

Liver disease: Green tea extract supplements have been linked to several cases of liver damage. Green tea extracts might make liver disease worse.

Weak bones (osteoporosis): Drinking green tea can increase the amount of calcium that is flushed out in the urine. Caffeine should be limited to less than 300 mg per day (approximately 2-3 cups of green tea). It is possible to make up for some calcium loss caused by caffeine by taking calcium supplements.

Are there interactions with medications?

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Do not take this combination.

Stimulant drugs such as amphetamines speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in green tea might also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.

Stimulant drugs such as cocaine speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in green tea might also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.

Stimulant drugs speed up the nervous system. Caffeine (contained in green tea) and ephedrine are both stimulant drugs. Taking green tea along with ephedrine might cause too much stimulation and sometimes serious side effects and heart problems. Do not take caffeine-containing products and ephedrine at the same time.

Nadolol (Corgard)
Green tea might decrease how much nadolol (Corgard) the body absorbs. Taking green tea along with nadolol (Corgard) might decrease the effectiveness of nadolol (Corgard).


Be cautious with this combination.

Adenosine (Adenocard)
Green tea contains caffeine. The caffeine in green tea might block the effects of adenosine (Adenocard). Adenosine (Adenocard) is often used by doctors to do a test on the heart, called a cardiac stress test. Stop consuming green tea or other caffeine-containing products at least 24 hours before a cardiac stress test.

Antibiotics (Quinolone antibiotics)
The body breaks down caffeine to get rid of it. Some antibiotics might decrease how quickly the body breaks down caffeine. Taking these antibiotics along with green tea can increase the risk of side effects including jitteriness, headache, increased heart rate, and other side effects.

Some antibiotics that decrease how quickly the body breaks down caffeine include ciprofloxacin (Cipro), enoxacin (Penetrex), norfloxacin (Chibroxin, Noroxin), sparfloxacin (Zagam), trovafloxacin (Trovan), and grepafloxacin (Raxar).

Birth control pills (Contraceptive drugs)
The body breaks down the caffeine in green tea to get rid of it. Birth control pills can decrease how quickly the body breaks down caffeine. Taking green tea along with birth control pills can cause jitteriness, headache, fast heartbeat, and other side effects.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.

Bortezomib (Velcade)
Bortezomib (Velcade) is used in certain types of cancers. Green tea might interact with bortezomib (Velcade) and decrease its effectiveness for treating certain types of cancer. If you take bortezomib (Velcade) avoid taking green tea products.

Cimetidine (Tagamet)
Green tea contains caffeine. The body breaks down caffeine to get rid of it. Cimetidine (Tagamet) can decrease how quickly your body breaks down caffeine. Taking cimetidine (Tagamet) along with green tea might increase the chance of caffeine side effects including jitteriness, headache, fast heartbeat, and others.

Clozapine (Clozaril)
The body breaks down clozapine (Clozaril) to get rid of it. The caffeine in green tea seems to decrease how quickly the body breaks down clozapine (Clozaril). Taking green tea along with clozapine (Clozaril) can increase the effects and side effects of clozapine (Clozaril).

Dipyridamole (Persantine)
Green tea contains caffeine. The caffeine in green tea might block the affects of dipyridamole (Persantine). Dipyridamole (Persantine) is often used by doctors to do a test on the heart called a cardiac stress test. Stop drinking green tea or other caffeine-containing products at least 24 hours before a cardiac stress test.

Disulfiram (Antabuse)
The body breaks down caffeine to get rid of it. Disulfiram (Antabuse) can decrease how quickly the body gets rid of caffeine. Taking green tea (which contains caffeine) along with disulfiram (Antabuse) might increase the effects and side effects of caffeine, including jitteriness, hyperactivity, irritability, and others.

The body breaks down the caffeine in green tea to get rid of it. Estrogens can decrease how quickly the body breaks down caffeine. Taking estrogen pills and drinking green tea can cause jitteriness, headache, fast heartbeat, and other side effects. If you take estrogen pills, limit your caffeine intake.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Fluvoxamine (Luvox)
The body breaks down the caffeine in green tea to get rid of it. Fluvoxamine (Luvox) can decrease how quickly the body breaks down caffeine. Taking green tea along with fluvoxamine (Luvox) might cause too much caffeine in the body, and increase the effects and side effects of caffeine.

Your body naturally gets rid of lithium. The caffeine in green tea can increase how quickly your body gets rid of lithium. If you take products that contain caffeine and you take lithium, stop taking caffeine products slowly. Stopping caffeine too quickly can increase the side effects of lithium.

Medications for asthma (Beta-adrenergic agonists)
Green tea contains caffeine. Caffeine can stimulate the heart. Some medications for asthma can also stimulate the heart. Taking caffeine with some medications for asthma might cause too much stimulation and cause heart problems.

Some medications for asthma include albuterol (Proventil, Ventolin, Volmax), metaproterenol (Alupent), terbutaline (Bricanyl, Brethine), and isoproterenol (Isuprel).

Medications for depression (MAOIs)
Caffeine in green tea can stimulate the body. Some medications used for depression can also stimulate the body. Taking green tea that contains caffeine along with some medications for depression might cause serious side effects including fast heartbeat, high blood pressure, nervousness, and others.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.

Medications moved by pumps in cells (Organic Anion-Transporting Polypeptide Substrates)
Some medications are moved by pumps in cells. Green tea might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective.

Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, nadolol (Corgard), paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).

Medications that can harm the liver (Hepatotoxic drugs)
Green tea extracts might harm the liver. Taking green tea extracts along with medication that might also harm the liver can increase the risk of liver damage. Do not take green tea extracts if you are taking a medication that can harm the liver.

Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin) , lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Green tea might slow blood clotting. Taking green tea along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include ardeparin (Normiflo), aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), dipyridamole (Persantine), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Medications used to treat cancer (Boronic acid-based proteasome inhibitors)
Green tea might interact with some medications used to treat cancer (boronic acid-based proteasome inhibitors). This might decrease its effectiveness of these medications for treating certain types of cancer. If you take one of these medications for cancer, avoid taking green tea products. Some of these drugs include bortezomib (Velcade).

Stimulant drugs such as nicotine speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and increase your heart rate. The caffeine in green tea might also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems, including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with caffeine.

Pentobarbital (Nembutal)
The stimulant effects of the caffeine in green tea can block the sleep-producing effects of pentobarbital (Nembutal).

Green tea contains caffeine. Caffeine can stimulate the body. Phenylpropanolamine can also stimulate the body. Taking green tea and phenylpropanolamine together might cause too much stimulation and increase heartbeat, increase blood pressure, and cause nervousness.

Riluzole (Rilutek)
The body breaks down riluzole (Rilutek) to get rid of it. Drinking green tea can decrease how quickly the body breaks down riluzole (Rilutek) and increase the effects and side effects of riluzole.

Stimulant drugs
Stimulant drugs speed up the nervous system and can make you feel jittery and speed up your heartbeat. Green tea contains caffeine, which can also speed up the nervous system. Taking green tea along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.

Green tea contains caffeine. Caffeine works similarly to theophylline. Caffeine can also decrease how quickly the body gets rid of theophylline. Taking green tea along with theophylline might increase the effects and side effects of theophylline.

Verapamil (Calan, Covera, Isoptin, Verelan)
The body breaks down the caffeine in green tea to get rid of it. Verapamil (Calan, Covera, Isoptin, Verelan) can decrease how quickly the body gets rid of caffeine. Drinking green tea and taking verapamil (Calan, Covera, Isoptin, Verelan) can increase the risk of side effects for caffeine including jitteriness, headache, and an increased heartbeat.

Warfarin (Coumadin)
Warfarin (Coumadin) is used to slow blood clotting. Large amounts of green tea have been reported to decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. It is unclear why this interaction might occur. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.


Be watchful with this combination.

The body breaks down the caffeine in green tea to get rid of it. Alcohol can decrease how quickly the body breaks down caffeine. Taking green tea along with alcohol might cause too much caffeine in the bloodstream and caffeine side effects including jitteriness, headache, and fast heartbeat.

Fluconazole (Diflucan)
Green tea contains caffeine. The body breaks down caffeine to get rid of it. Fluconazole (Diflucan) might decrease how quickly the body gets rid of caffeine and cause caffeine to stay in the body too long. Taking fluconazole (Diflucan) along with green tea might increase the risk of side effects such as nervousness, anxiety, and insomnia.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Some medications are changed and broken down by the liver. Green tea might decrease how quickly the liver breaks down some medications. Taking green tea while taking some medications that are broken down by the liver can increase the effects and side effects of some medications. However, it is not known if this is a big concern. Talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Medications for diabetes (Antidiabetes drugs)
Green tea contains caffeine. There is conflicting evidence that caffeine might either increase or decrease blood sugar. Diabetes medications are used to lower blood sugar. Taking some medications for diabetes along with caffeine might decrease the effectiveness of diabetes medications. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Mexiletine (Mexitil)
Green tea contains caffeine. The body breaks down caffeine to get rid of it. Mexiletine (Mexitil) can decrease how quickly the body breaks down caffeine. Taking Mexiletine (Mexitil) along with green tea might increase the caffeine effects and side effects of green tea.

Midazolam (Versed)
The body breaks down midazolam (Versed) to get rid of it. Green tea might decrease how quickly the body breaks down midazolam (Versed). Taking green tea along with midazolam (Versed) might increase the effects and side effects of midazolam (Versed). However, it is not known if this is a big concern. Talk with you healthcare provider if you are taking midazolam.

Terbinafine (Lamisil)
The body breaks down the caffeine in green tea to get rid of it. Terbinafine (Lamisil) can decrease how fast the body gets rid of caffeine. Taking green tea along with terbinafine (Lamisil) can increase the risk of caffeine side effects including jitteriness, headache, increased heartbeat, and other effects.

Are there interactions with herbs and supplements?

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Bitter orange
Bitter orange, used along with caffeine or caffeine-containing herbs such as green tea, can increase blood pressure and heart rate in otherwise healthy people. This might damage the heart and blood vessels.

Caffeine-containing herbs and supplements
Green tea contains caffeine. Using green tea along with other herbs and supplements that contain caffeine might increase the effects of caffeine, and also its unwanted side effects. Some natural products that contain caffeine include coffee, black tea, oolong tea, guarana, mate, cola, and others.

Green tea contains caffeine. High doses of caffeine can lead to loss of too much calcium in the urine.

There is some concern that combining caffeine, ephedra, and creatine might increase the risk of serious unwanted side effects. One athlete who used this combination, as well as some other supplements to improve his performance, suffered a stroke. Researchers worry the stroke might have been caused by the supplements.

Ephedra (Ma Huang)
Don't take green tea with ephedra. The caffeine in green tea might increase the effects of ephedra. Using ephedra with caffeine might increase the risk of serious life-threatening or disabling conditions such as hypertension, heart attack, stroke, seizures, and death.

Folic acid
There is some concern that green tea might decrease the activity of folic acid, leaving the body with less than the amount of folic acid it needs.

Herbs and supplements that may slow blood clotting (Anticoagulant/Antiplatelet herbs and supplements)
Green tea contains caffeine. Caffeine may slow blood clotting. Using green tea along with other herbs and supplements that might also slow blood clotting could increase the risk of bleeding in some people. Some of these herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, and others.

Herbs and supplements that might harm the liver
In several cases, people who took green tea developed liver damage. Researchers worry that the damage might have been linked to the green tea. Taking green tea extracts with other herbs or supplements that might harm the liver could increase the risk of harm to the liver. Other products that might adversely affect the liver include bishop's weed, borage, chaparral, uva ursi, and others.

Green tea might reduce the absorption of iron supplements. For most people, this effect will not be enough to make a difference in their health. But people who don't have enough iron in their system would be wise to drink green tea between meals rather than with meals to lessen this interaction.

Green tea contains caffeine. Caffeine can increase how quickly the body releases magnesium in the urine.

Are there interactions with foods?

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Green tea appears to reduce absorption of iron from foods.

Adding milk to tea seems to reduce some of tea's benefits for the heart and blood vessels. Milk might bind and prevent absorption of the antioxidants in tea. But this is controversial. More research is needed to find out how important this interaction really is.

What dose is used?

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The following doses have been studied in scientific research:

Doses of green tea vary significantly, but usually range between 1-10 cups daily. The commonly used dose of green tea is based on the amount typically consumed in Asian countries, which is about 3 cups per day, providing 240-320 mg of the active ingredients, polyphenols. To make tea, people typically use 1 teaspoon of tea leaves in 8 ounces boiling water.
  • For headache or restoring mental alertness: tea providing is up to 250 mg of caffeine per day, or approximately 3 cups of tea per day.
  • For improving thinking: tea providing 60 mg of caffeine, or approximately one cup.
  • For reducing cholesterol: drinking 10 or more cups per day has been associated with decreased cholesterol levels. Theaflavin-enriched green tea extract, 375 mg daily for 12 weeks, has also been used for lowering cholesterol.
  • For human papilloma virus (HPV) infections of the cervix: green tea extract, 200 mg daily alone or in combination with topical green tea ointment, for 8-12 weeks.
  • For preventing Parkinson’s disease:
    • Men consuming 421-2716 mg total caffeine (approximately 5-33 cups of green tea) daily have the lowest risk of developing Parkinson’s disease. However, a significantly lower risk is also associated with consumption of as little as 124-208 mg of caffeine (approximately 1-3 cups of green tea) daily.
    • In women: more moderate caffeine consumption seems to be best, equivalent to approximately 1-4 cups of green tea per day.
  • For human papillomavirus (HPV) infections of the cervix: green tea ointment alone or in combination with oral green tea extract, twice weekly for 8-12 weeks.
  • For genital warts: a specific green tea extract ointment (Veregen, Bradley Pharmaceuticals) providing 15% kunecatechins applied three times daily to external warts for up to 16 weeks has been used.

Other names

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Camellia sinensis, Camellia thea, Camellia theifera, Constituant Polyphénolique de Thé Vert, CPTV, EGCG, Epigallo Catechin Gallate, Épigallo-Catéchine Gallate, Epigallocatechin Gallate, Extrait de Camellia Sinensis, Extrait de Thé, Extrait de Thé Vert, Extrait de Thea Sinensis, Green Sencha Tea, Green Tea Extract, Green Tea Polyphenolic Fraction, GTP, GTPF, Japanese Tea, Kunecatechins, Poly E, Polyphenon E, PTV, Té Verde, Tea, Tea Extract, Tea Green, Thé, Thé de Camillia, Thé Japonais, Thé Vert, Thé Vert de Yame, Thé Vert Sensha, Thea bohea, Thea sinensis, Thea viridis, Yame Green Tea, Yame Tea.


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  1. Yian LG. Case study on the effectiveness of green tea bags as a secondary dressing to control malodour of fungating breast cancer wounds. Singapore Nurs J 2005;32:42-48.
  2. Syed TA, Ahmad SA. Wong W. et al. Clinical evaluation of 2 polyphenone (green tea extract) in a hydrophilic gel to assess improvement in aged and damaged facial skin: a placebo-controlled, double-blind study [abstract]. 20th Worid Congress of Dermatology; 2002;1.
  3. Mu, D., Yu, J. X., and Li, D. Obervation on the therapeutic effect in the treatment of 26 patients with fatty liver by tea pigment capsules (in Chinese). J Norman Bethune Univ Med Sci 1997;23:528-530.
  4. Mou, N. Z, Ren, G. L., Mou, L. H., and Lu, C. T. Reasearch on the influence of catechin on fatty liver disease (in Chinese). Shandong J Traditional Chin Med 1998;17:55-56.
  5. Mu, L. N., Zhou, X. F., Ding, B. G., and Wang, R. H. Study on the protective effect of preen tea on gastric, liver and esophageal cancer (in Chinese). Chin J Prev Med 2003;37:171-173.
  6. Xiao, J. P., Shen, X. N., Wu, M., and Lu, R. F. Epidemiologic survey on the association between green tea intake and fatty liver disease (in Chinese). China Public Health 2002;18:385-387.
  7. Shen, H. B., Xu, Y. C., Shen, J., and Niu, J. Y. The relationship between habit of drinking green tea and primary liver cancer:a case control study (in Chinese). Clin J Behav Med Sci 1996;5:588-589.
  8. Yuan, Y. B., Wang, Z. Q., Hu, X. X., and Jiang, Q. W. Cohort study of drinking green tea on liver disease (in Chinese). Pract Prev Med 2005;12:1016-1018.
  9. Xu, Y. C., Shen, H. B., Niu, J. Y., and Shen, J. An intervention trial with green tea on high risk population of primary liver cancer (in Chinese). Cancer Res Prev Treatment 1998;25:223-225.
  10. Zhang, Z. Q., Lui, Q. F., Huang, Y. R., and Wu, Y. D. An epidemiological trial of using green tea to prevent liver cancer (in Chinese). GuangXi Prev Med 1995;1:5-7.
  1. Tsubono Y and Tsugane S. Green tea intake in relation to serum lipid levels in middle-aged japanese men and women. Ann Epidemiol 1997;7:280-284.
  2. Tao M, Liu D Gao L Jin F. Association between green tea drinking and breast cancer risk. Tumor 2002;22:11-15.
  3. Takeshita M, Takashima S Harada U Shibata E Hosoya N Takase H et al. Effects of long-term consumption of tea catechins-enriched beverage with no caffeine on body composition in humans. Japanese Pharmacology and Therapeutics 2008;36:767-776.
  4. Bordoni A, Hrelia S, Angeloni C, and et al. Green tea protection of hypoxia/reoxygenation injury in cultured cardiac cells. J Nutr Biochem 2002;13:103-111.
  5. Mason R. 200mg of Zen; L-theanine boosts alpha waves, promotes alert relaxation. Alternative and Complementary Therapies 2001;April:91-95.
  6. Rasheed A and Haider M. Antibacterial activity of Camellia sinensis extracts against dental caries. Arch Pharm Res 1998;21:348-352.
  7. Cronin JR. Green tea extract stokes thermogenesis. Alternative and Complementary Therapies 2000;296-300.
  8. Dufresne CJ and Farnworth ER. A review of latest research findings on the health promotion properties of tea. Journal of Nutritional Biochemistry 2001;12:404-421.
  9. Hardy ML. Clinician Fact Sheet. Alternative Medicine Alert 2000;3:s1-s2.
  10. Pietta, P., Simonetti, P., Gardana, C., Brusamolino, A., Morazzoni, P., and Bombardelli, E. Relationship between rate and extent of catechin absorption and plasma antioxidant status. Biochem Mol.Biol Int. 1998;46:895-903. View abstract.
  11. Fujiki, H., Suganuma, M., Okabe, S., Sueoka, N., Komori, A., Sueoka, E., Kozu, T., Tada, Y., Suga, K., Imai, K., and Nakachi, K. Cancer inhibition by green tea. Mutat.Res 6-18-1998;402(1-2):307-310. View abstract.
  12. Nakachi, K., Suemasu, K., Suga, K., Takeo, T., Imai, K., and Higashi, Y. Influence of drinking green tea on breast cancer malignancy among Japanese patients. Jpn J Cancer Res 1998;89:254-261. View abstract.
  13. Okai, Y. and Higashi-Okai, K. Potent suppressing activity of the non-polyphenolic fraction of green tea (Camellia sinensis) against genotoxin-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002)--association with pheophytins a and b. Cancer Lett. 11-25-1997;120:117-123. View abstract.
  14. Yang, C. S., Chen, L., Lee, M. J., Balentine, D., Kuo, M. C., and Schantz, S. P. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol.Biomarkers Prev. 1998;7:351-354. View abstract.
  15. Nagata, C., Kabuto, M., and Shimizu, H. Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women. Nutr Cancer 1998;30:21-24. View abstract.
  16. Nakagawa, K., Okuda, S., and Miyazawa, T. Dose-dependent incorporation of tea catechins, (-)-epigallocatechin-3- gallate and (-)-epigallocatechin, into human plasma. Biosci.Biotechnol.Biochem 1997;61:1981-1985. View abstract.
  17. Imai, K., Suga, K., and Nakachi, K. Cancer-preventive effects of drinking green tea among a Japanese population. Prev.Med 1997;26:769-775. View abstract.
  18. Yang, T. T. and Koo, M. W. Hypocholesterolemic effects of Chinese tea. Pharmacol Res 1997;35:505-512. View abstract.
  19. Jankun, J., Selman, S. H., Swiercz, R., and Skrzypczak-Jankun, E. Why drinking green tea could prevent cancer. Nature 6-5-1997;387:561. View abstract.
  20. Yokozawa, T., Dong, E., and Oura, H. Proof that green tea tannin suppresses the increase in the blood methylguanidine level associated with renal failure. Exp Toxicol.Pathol. 1997;49(1-2):117-122. View abstract.
  21. Ji, B. T., Chow, W. H., Hsing, A. W., McLaughlin, J. K., Dai, Q., Gao, Y. T., Blot, W. J., and Fraumeni, J. F., Jr. Green tea consumption and the risk of pancreatic and colorectal cancers. Int J Cancer 1-27-1997;70:255-258. View abstract.
  22. Luo, M., Kannar, K., Wahlqvist, M. L., and O'Brien, R. C. Inhibition of LDL oxidation by green tea extract. Lancet 2-1-1997;349:360-361. View abstract.
  23. Unno, T., Kondo, K., Itakura, H., and Takeo, T. Analysis of (-)-epigallocatechin gallate in human serum obtained after ingesting green tea. Biosci.Biotechnol.Biochem 1996;60:2066-2068. View abstract.
  24. Wilkens, L. R., Kadir, M. M., Kolonel, L. N., Nomura, A. M., and Hankin, J. H. Risk factors for lower urinary tract cancer: the role of total fluid consumption, nitrites and nitrosamines, and selected foods. Cancer Epidemiol.Biomarkers Prev. 1996;5:161-166. View abstract.
  25. Yu, G. P., Hsieh, C. C., Wang, L. Y., Yu, S. Z., Li, X. L., and Jin, T. H. Green-tea consumption and risk of stomach cancer: a population-based case-control study in Shanghai, China. Cancer Causes Control 1995;6:532-538. View abstract.
  26. Sakamoto, O., Saita, N., Yamasaki, H., Tamanoi, M., and Ando, M. Pulmonary granulomatosis caused by aspirated green tea. Chest 1994;106:308-309. View abstract.
  27. Shirai, T., Sato, A., and Hara, Y. Epigallocatechin gallate. The major causative agent of green tea-induced asthma. Chest 1994;106:1801-1805. View abstract.
  28. Iwamoto, N., Nakakuma, H., Ota, N., Shimokado, H., and Takatsuki, K. Ascorbic acid-induced hemolysis of paroxysmal nocturnal hemoglobinuria erythrocytes. Am.J Hematol. 1994;47:337-338. View abstract.
  29. Bu-Abbas, A., Clifford, M. N., Walker, R., and Ioannides, C. Marked antimutagenic potential of aqueous green tea extracts: mechanism of action. Mutagenesis 1994;9:325-331. View abstract.
  30. Shim, J. S., Kang, M. H., Kim, Y. H., Roh, J. K., Roberts, C., and Lee, I. P. Chemopreventive effect of green tea (Camellia sinensis) among cigarette smokers. Cancer Epidemiol Biomarkers Prev 1995;4:387-391. View abstract.
  31. Fitzpatrick, D. F., Hirschfield, S. L., Ricci, T., Jantzen, P., and Coffey, R. G. Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc.Pharmacol. 1995;26:90-95. View abstract.
  32. Severson, R. K., Nomura, A. M., Grove, J. S., and Stemmermann, G. N. A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii. Cancer Res. 4-1-1989;49:1857-1860. View abstract.
  33. Sato, Y., Nakatsuka, H., Watanabe, T., Hisamichi, S., Shimizu, H., Fujisaku, S., Ichinowatari, Y., Ida, Y., Suda, S., Kato, K., and . Possible contribution of green tea drinking habits to the prevention of stroke. Tohoku J Exp Med 1989;157:337-343. View abstract.
  34. Sagesaka-Mitane, Y., Miwa, M., and Okada, S. Platelet aggregation inhibitors in hot water extract of green tea. Chem Pharm Bull.(Tokyo) 1990;38:790-793. View abstract.
  35. Wu, S., Li, F., Huang, X., Hua, Q., Huang, T., Liu, Z., Liu, Z., Zhang, Z., Liao, C., Chen, Y., Shi, Y., Zeng, R., Feng, M., Zhong, X., Long, Z., Tan, W., and Zhang, X. The association of tea consumption with bladder cancer risk: a meta-analysis. Asia Pac.J.Clin.Nutr. 2013;22:128-137. View abstract.
  36. Jurgens, T. M., Whelan, A. M., Killian, L., Doucette, S., Kirk, S., and Foy, E. Green tea for weight loss and weight maintenance in overweight or obese adults. Cochrane.Database.Syst.Rev. 2012;12:CD008650. View abstract.
  37. Yoto, A., Motoki, M., Murao, S., and Yokogoshi, H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J.Physiol Anthropol. 2012;31:28. View abstract.
  38. Yoon, J. Y., Kwon, H. H., Min, S. U., Thiboutot, D. M., and Suh, D. H. Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes. J.Invest Dermatol. 2013;133:429-440. View abstract.
  39. Mangine, G. T., Gonzalez, A. M., Wells, A. J., McCormack, W. P., Fragala, M. S., Stout, J. R., and Hoffman, J. R. The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: a double-blind, randomized control trial. Lipids Health Dis. 2012;11:127. View abstract.
  40. Subramaniam, P., Eswara, U., and Maheshwar Reddy, K. R. Effect of different types of tea on Streptococcus mutans: an in vitro study. Indian J.Dent.Res. 2012;23:43-48. View abstract.
  41. Pudney, P. D., Bonnist, E. Y., Caspers, P. J., Gorce, J. P., Marriot, C., Puppels, G. J., Singleton, S., and van der Wolf, M. J. A new in vivo Raman probe for enhanced applicability to the body. Appl.Spectrosc. 2012;66:882-891. View abstract.
  42. Shanafelt, T. D., Call, T. G., Zent, C. S., Leis, J. F., LaPlant, B., Bowen, D. A., Roos, M., Laumann, K., Ghosh, A. K., Lesnick, C., Lee, M. J., Yang, C. S., Jelinek, D. F., Erlichman, C., and Kay, N. E. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer 1-15-2013;119:363-370. View abstract.
  43. Bogdanski, P., Suliburska, J., Szulinska, M., Stepien, M., Pupek-Musialik, D., and Jablecka, A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr.Res. 2012;32:421-427. View abstract.
  44. Ali, M., Afzal, M., Gubler, C. J., and Burka, J. F. A potent thromboxane formation inhibitor in green tea leaves. Prostaglandins Leukot.Essent.Fatty Acids 1990;40:281-283. View abstract.
  45. Cha, K. H., Song, D. G., Kim, S. M., and Pan, C. H. Inhibition of gastrointestinal lipolysis by green tea, coffee, and gomchui (Ligularia fischeri) tea polyphenols during simulated digestion. J.Agric.Food Chem. 7-25-2012;60:7152-7157. View abstract.
  46. Miller, R. J., Jackson, K. G., Dadd, T., Mayes, A. E., Brown, A. L., Lovegrove, J. A., and Minihane, A. M. The impact of the catechol-O-methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion. Mol.Nutr.Food Res. 2012;56:966-975. View abstract.
  47. Kristen, A. V., Lehrke, S., Buss, S., Mereles, D., Steen, H., Ehlermann, P., Hardt, S., Giannitsis, E., Schreiner, R., Haberkorn, U., Schnabel, P. A., Linke, R. P., Rocken, C., Wanker, E. E., Dengler, T. J., Altland, K., and Katus, H. A. Green tea halts progression of cardiac transthyretin amyloidosis: an observational report. Clin.Res.Cardiol. 2012;101:805-813. View abstract.
  48. Mahmood, T., Akhtar, N., Khan, B. A., Shoaib Khan, H. M., and Saeed, T. Changes in skin mechanical properties after long-term application of cream containing green tea extract. Aging Clin.Exp.Res. 2011;23(5-6):333-336. View abstract.
  49. Kim, H. J., Kim, J. H., Chie, E. K., Young, P. D., Kim, I. A., and Kim, I. H. DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity. Radiat.Oncol. 2012;7:39. View abstract.
  50. Du, X., Huang, X., Huang, C., Wang, Y., and Zhang, Y. Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive. J.Dent. 2012;40:485-492. View abstract.
  51. Wightman, E. L., Haskell, C. F., Forster, J. S., Veasey, R. C., and Kennedy, D. O. Epigallocatechin gallate, cerebral blood flow parameters, cognitive performance and mood in healthy humans: a double-blind, placebo-controlled, crossover investigation. Hum.Psychopharmacol. 2012;27:177-186. View abstract.
  52. Pekal, A., Drozdz, P., Biesaga, M., and Pyrzynska, K. Screening of the antioxidant properties and polyphenol composition of aromatised green tea infusions. J.Sci.Food Agric. 8-30-2012;92:2244-2249. View abstract.
  53. Wu, A. H., Spicer, D., Stanczyk, F. Z., Tseng, C. C., Yang, C. S., and Pike, M. C. Effect of 2-month controlled green tea intervention on lipoprotein cholesterol, glucose, and hormone levels in healthy postmenopausal women. Cancer Prev.Res.(Phila) 2012;5:393-402. View abstract.
  54. Scholey, A., Downey, L. A., Ciorciari, J., Pipingas, A., Nolidin, K., Finn, M., Wines, M., Catchlove, S., Terrens, A., Barlow, E., Gordon, L., and Stough, C. Acute neurocognitive effects of epigallocatechin gallate (EGCG). Appetite 2012;58:767-770. View abstract.
  55. Suyama, E., Tamura, T., Ozawa, T., Suzuki, A., Iijima, Y., and Saito, T. Remineralization and acid resistance of enamel lesions after chewing gum containing fluoride extracted from green tea. Aust.Dent.J. 2011;56:394-400. View abstract.
  56. Jowko, E., Sacharuk, J., Balasinska, B., Ostaszewski, P., Charmas, M., and Charmas, R. Green tea extract supplementation gives protection against exercise-induced oxidative damage in healthy men. Nutr.Res. 2011;31:813-821. View abstract.
  57. Persson, I. A. The pharmacological mechanism of angiotensin-converting enzyme inhibition by green tea, Rooibos and enalaprilat - a study on enzyme kinetics. Phytother.Res. 2012;26:517-521. View abstract.
  58. Dunne, E. F., Friedman, A., Datta, S. D., Markowitz, L. E., and Workowski, K. A. Updates on human papillomavirus and genital warts and counseling messages from the 2010 Sexually Transmitted Diseases Treatment Guidelines. Clin.Infect.Dis. 2011;53 Suppl 3:S143-S152. View abstract.
  59. Nguyen, M. M., Ahmann, F. R., Nagle, R. B., Hsu, C. H., Tangrea, J. A., Parnes, H. L., Sokoloff, M. H., Gretzer, M. B., and Chow, H. H. Randomized, double-blind, placebo-controlled trial of polyphenon E in prostate cancer patients before prostatectomy: evaluation of potential chemopreventive activities. Cancer Prev.Res.(Phila) 2012;5:290-298. View abstract.
  60. Yang, H. Y., Yang, S. C., Chao, J. C., and Chen, J. R. Beneficial effects of catechin-rich green tea and inulin on the body composition of overweight adults. Br.J.Nutr. 2012;107:749-754. View abstract.
  61. Kim, A., Chiu, A., Barone, M. K., Avino, D., Wang, F., Coleman, C. I., and Phung, O. J. Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis. J.Am.Diet.Assoc. 2011;111:1720-1729. View abstract.
  62. Braga, M., Bissolati, M., Rocchetti, S., Beneduce, A., Pecorelli, N., and Di, Carlo, V. Oral preoperative antioxidants in pancreatic surgery: a double-blind, randomized, clinical trial. Nutrition 2012;28:160-164. View abstract.
  63. Stingl, J. C., Ettrich, T., Muche, R., Wiedom, M., Brockmoller, J., Seeringer, A., and Seufferlein, T. Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. BMC.Cancer 2011;11:360. View abstract.
  64. Rosmarin, P. C., Applegate, W. B., and Somes, G. W. Coffee consumption and serum lipids: a randomized, crossover clinical trial. Am J Med 1990;88:349-356. View abstract.
  65. Park, M., Yamada, H., Matsushita, K., Kaji, S., Goto, T., Okada, Y., Kosuge, K., and Kitagawa, T. Green tea consumption is inversely associated with the incidence of influenza infection among schoolchildren in a tea plantation area of Japan. J.Nutr. 2011;141:1862-1870. View abstract.
  66. Scoccianti, C., Ricceri, F., Ferrari, P., Cuenin, C., Sacerdote, C., Polidoro, S., Jenab, M., Hainaut, P., Vineis, P., and Herceg, Z. Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study. Epigenetics. 9-1-2011;6:1114-1119. View abstract.
  67. Xu, H., Becker, C. M., Lui, W. T., Chu, C. Y., Davis, T. N., Kung, A. L., Birsner, A. E., D'Amato, R. J., Wai Man, G. C., and Wang, C. C. Green tea epigallocatechin-3-gallate inhibits angiogenesis and suppresses vascular endothelial growth factor C/vascular endothelial growth factor receptor 2 expression and signaling in experimental endometriosis in vivo. Fertil.Steril. 2011;96:1021-1028. View abstract.
  68. Ciotta, L., Stracquadanio, M., Formuso, C., Di, Leo S., Ando, A., and Pagano, I. [Clinical effectiveness of N-oleyl-phosphatidyl-ethanolamine (NOPE) in obesity: our experience]. Minerva Gastroenterol.Dietol. 2011;57:323-331. View abstract.
  69. Shen, C. L., Chyu, M. C., Yeh, J. K., Zhang, Y., Pence, B. C., Felton, C. K., Brismee, J. M., Arjmandi, B. H., Doctolero, S., and Wang, J. S. Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial. Osteoporos.Int. 2012;23:1541-1552. View abstract.
  70. Brown, A. L., Lane, J., Holyoak, C., Nicol, B., Mayes, A. E., and Dadd, T. Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Br.J.Nutr. 2011;106:1880-1889. View abstract.
  71. Zheng, X. X., Xu, Y. L., Li, S. H., Liu, X. X., Hui, R., and Huang, X. H. Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials. Am.J.Clin.Nutr. 2011;94:601-610. View abstract.
  72. Hwang, J. Y., Choi, S. C., Park, J. H., and Kang, S. W. The use of green tea extract as a storage medium for the avulsed tooth. J.Endod. 2011;37:962-967. View abstract.
  73. Zheng, J., Yang, B., Huang, T., Yu, Y., Yang, J., and Li, D. Green tea and black tea consumption and prostate cancer risk: an exploratory meta-analysis of observational studies. Nutr.Cancer 2011;63:663-672. View abstract.
  74. Hsu, C. H., Liao, Y. L., Lin, S. C., Tsai, T. H., Huang, C. J., and Chou, P. Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial. Altern.Med.Rev. 2011;16:157-163. View abstract.
  75. Ferrazzano, G. F., Roberto, L., Amato, I., Cantile, T., Sangianantoni, G., and Ingenito, A. Antimicrobial properties of green tea extract against cariogenic microflora: an in vivo study. J.Med.Food 2011;14:907-911. View abstract.
  76. Liu Y, Flynn TJ Ferguson MS Hoagland EM Yu LL. Effects of dietary phenolics and botanical extracts on hepatotoxicity-related endpoints in human and rat hepatoma cells and statistical models for prediction of hepatotoxicity. Food Chem Toxicol. 2011;49:1820-1827. View abstract.
  77. Forester, S. C. and Lambert, J. D. The role of antioxidant versus pro-oxidant effects of green tea polyphenols in cancer prevention. Mol.Nutr.Food Res. 2011;55:844-854. View abstract.
  78. Heinrich, U., Moore, C. E., De, Spirt S., Tronnier, H., and Stahl, W. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women. J.Nutr. 2011;141:1202-1208. View abstract.
  79. Uckun, F. M., Qazi, S., Ozer, Z., Garner, A. L., Pitt, J., Ma, H., and Janda, K. D. Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network. Br.J.Haematol. 2011;153:741-752. View abstract.
  80. Karth, A., Holoshitz, N., Kavinsky, C. J., Trohman, R., and McBride, B. F. A case report of atrial fibrillation potentially induced by hydroxycut: a multicomponent dietary weight loss supplement devoid of sympathomimetic amines. J.Pharm.Pract. 2010;23:245-249. View abstract.
  81. Yellapu, R. K., Mittal, V., Grewal, P., Fiel, M., and Schiano, T. Acute liver failure caused by 'fat burners' and dietary supplements: a case report and literature review. Can.J.Gastroenterol. 2011;25:157-160. View abstract.
  82. Murao, T., Sakurai, K., Mihara, S., Marubayashi, T., Murakami, Y., and Sasaki, Y. Lifestyle change influences on GERD in Japan: a study of participants in a health examination program. Dig.Dis.Sci. 2011;56:2857-2864. View abstract.
  83. Otera, H., Tada, K., Sakurai, T., Hashimoto, K., and Ikeda, A. Hypersensitivity pneumonitis associated with inhalation of catechin-rich green tea extracts. Respiration 2011;82:388-392. View abstract.
  84. Miller, R. J., Jackson, K. G., Dadd, T., Nicol, B., Dick, J. L., Mayes, A. E., Brown, A. L., and Minihane, A. M. A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. Eur.J.Nutr. 2012;51:47-55. View abstract.
  85. Awadalla, H. I., Ragab, M. H., Bassuoni, M. W., Fayed, M. T., and Abbas, M. O. A pilot study of the role of green tea use on oral health. Int.J.Dent.Hyg. 2011;9:110-116. View abstract.
  86. Matsumoto, K., Yamada, H., Takuma, N., Niino, H., and Sagesaka, Y. M. Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial. BMC.Complement Altern.Med. 2011;11:15. View abstract.
  87. Vu, H. A., Beppu, Y., Chi, H. T., Sasaki, K., Yamamoto, H., Xinh, P. T., Tanii, T., Hara, Y., Watanabe, T., Sato, Y., and Ohdomari, I. Green tea epigallocatechin gallate exhibits anticancer effect in human pancreatic carcinoma cells via the inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor. J.Biomed.Biotechnol. 2010;2010:290516. View abstract.
  88. Park, S. K., Jung, I. C., Lee, W. K., Lee, Y. S., Park, H. K., Go, H. J., Kim, K., Lim, N. K., Hong, J. T., Ly, S. Y., and Rho, S. S. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J.Med.Food 2011;14:334-343. View abstract.
  89. Tzellos, T. G., Sardeli, C., Lallas, A., Papazisis, G., Chourdakis, M., and Kouvelas, D. Efficacy, safety and tolerability of green tea catechins in the treatment of external anogenital warts: a systematic review and meta-analysis. J.Eur.Acad.Dermatol.Venereol. 2011;25:345-353. View abstract.
  90. Wang, Z. M., Zhou, B., Wang, Y. S., Gong, Q. Y., Wang, Q. M., Yan, J. J., Gao, W., and Wang, L. S. Black and green tea consumption and the risk of coronary artery disease: a meta-analysis. Am.J.Clin.Nutr. 2011;93:506-515. View abstract.
  91. Rohde, J., Jacobsen, C., and Kromann-Andersen, H. [Toxic hepatitis triggered by green tea]. Ugeskr.Laeger 1-17-2011;173:205-206. View abstract.
  92. Kurbitz, C., Heise, D., Redmer, T., Goumas, F., Arlt, A., Lemke, J., Rimbach, G., Kalthoff, H., and Trauzold, A. Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. Cancer Sci. 2011;102:728-734. View abstract.
  93. Miller, R. J., Jackson, K. G., Dadd, T., Mayes, A. E., Brown, A. L., and Minihane, A. M. The impact of the catechol-O-methyltransferase genotype on the acute responsiveness of vascular reactivity to a green tea extract. Br.J.Nutr. 2011;105:1138-1144. View abstract.
  94. Shen, C. L., Chyu, M. C., Pence, B. C., Yeh, J. K., Zhang, Y., Felton, C. K., Doctolero, S., and Wang, J. S. Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report. BMC.Complement Altern.Med. 2010;10:76. View abstract.
  95. Oyama, J., Maeda, T., Sasaki, M., Kozuma, K., Ochiai, R., Tokimitsu, I., Taguchi, S., Higuchi, Y., and Makino, N. Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers. Intern.Med. 2010;49:2553-2559. View abstract.
  96. Josic, J., Olsson, A. T., Wickeberg, J., Lindstedt, S., and Hlebowicz, J. Does green tea affect postprandial glucose, insulin and satiety in healthy subjects: a randomized controlled trial. Nutr.J. 2010;9:63. View abstract.
  97. Hunt, K. J., Hung, S. K., and Ernst, E. Botanical extracts as anti-aging preparations for the skin: a systematic review. Drugs Aging 12-1-2010;27:973-985. View abstract.
  98. Rodriguez-Ramiro, I., Martin, M. A., Ramos, S., Bravo, L., and Goya, L. Comparative effects of dietary flavanols on antioxidant defences and their response to oxidant-induced stress on Caco2 cells. Eur.J.Nutr. 2011;50:313-322. View abstract.
  99. Choung, Y. H., Choi, S. J., Joo, J. S., Lee, J. B., Lee, H. K., and Lee, S. J. Green tea prevents down-regulation of gap junction intercellular communication in human keratinocytes treated with PMA. Eur.Arch.Otorhinolaryngol. 2011;268:885-892. View abstract.
  100. Kawai, K., Tsuno, N. H., Kitayama, J., Sunami, E., Takahashi, K., and Nagawa, H. Catechin inhibits adhesion and migration of peripheral blood B cells by blocking CD11b. Immunopharmacol.Immunotoxicol. 2011;33:391-397. View abstract.
  101. Xu, X., Zhou, X. D., and Wu, C. D. Tea catechin EGCg suppresses the mgl gene associated with halitosis. J.Dent.Res. 2010;89:1304-1308. View abstract.
  102. Schwarz, B., Bischof, H. P., and Kunze, M. Coffee and cardiovascular risk: epidemiological findings in Austria. Int.J Epidemiol. 1990;19:894-898. View abstract.
  103. Lastawska, K. Evaluation of selected food supplements containing antioxidants. Rocz.Panstw.Zakl.Hig. 2010;61:151-154. View abstract.
  104. Domingo, D. S., Camouse, M. M., Hsia, A. H., Matsui, M., Maes, D., Ward, N. L., Cooper, K. D., and Baron, E. D. Anti-angiogenic effects of epigallocatechin-3-gallate in human skin. Int.J.Clin.Exp.Pathol. 2010;3:705-709. View abstract.
  105. Han, K. C., Wong, W. C., and Benzie, I. F. Genoprotective effects of green tea (Camellia sinensis) in human subjects: results of a controlled supplementation trial. Br.J.Nutr. 2011;105:171-179. View abstract.
  106. Stendell-Hollis, N. R., Thomson, C. A., Thompson, P. A., Bea, J. W., Cussler, E. C., and Hakim, I. A. Green tea improves metabolic biomarkers, not weight or body composition: a pilot study in overweight breast cancer survivors. J.Hum.Nutr.Diet. 2010;23:590-600. View abstract.
  107. Lonac, M. C., Richards, J. C., Schweder, M. M., Johnson, T. K., and Bell, C. Influence of Short-Term Consumption of the Caffeine-Free, Epigallocatechin-3-Gallate Supplement, Teavigo, on Resting Metabolism and the Thermic Effect of Feeding. Obesity.(Silver.Spring) 8-19-2010; View abstract.
  108. Renouf, M., Guy, P., Marmet, C., Longet, K., Fraering, A. L., Moulin, J., Barron, D., Dionisi, F., Cavin, C., Steiling, H., and Williamson, G. Plasma appearance and correlation between coffee and green tea metabolites in human subjects. Br.J Nutr. 8-9-2010;1-6. View abstract.
  109. Roomi, M. W., Monterrey, J. C., Kalinovsky, T., Rath, M., and Niedzwiecki, A. Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines. Oncol.Rep. 2010;24:747-757. View abstract.
  110. Wang, P., Aronson, W. J., Huang, M., Zhang, Y., Lee, R. P., Heber, D., and Henning, S. M. Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention. Cancer Prev.Res.(Phila Pa) 2010;3:985-993. View abstract.
  111. Basu, A., Du, M., Sanchez, K., Leyva, M. J., Betts, N. M., Blevins, S., Wu, M., Aston, C. E., and Lyons, T. J. Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome. Nutrition 2011;27:206-213. View abstract.
  112. Basu, A., Sanchez, K., Leyva, M. J., Wu, M., Betts, N. M., Aston, C. E., and Lyons, T. J. Green tea supplementation affects body weight, lipids, and lipid peroxidation in obese subjects with metabolic syndrome. J Am.Coll.Nutr. 2010;29:31-40. View abstract.
  113. Muller, N., Ellinger, S., Alteheld, B., Ulrich-Merzenich, G., Berthold, H. K., Vetter, H., and Stehle, P. Bolus ingestion of white and green tea increases the concentration of several flavan-3-ols in plasma, but does not affect markers of oxidative stress in healthy non-smokers. Mol.Nutr.Food Res. 6-10-2010; View abstract.
  114. da Costa Santos, C. M., de Mattos Pimenta, C. A., and Nobre, M. R. A systematic review of topical treatments to control the odor of malignant fungating wounds. J Pain Symptom.Manage. 2010;39:1065-1076. View abstract.
  115. Eichenberger, P., Mettler, S., Arnold, M., and Colombani, P. C. No effects of three-week consumption of a green tea extract on time trial performance in endurance-trained men. Int J Vitam.Nutr.Res. 2010;80:54-64. View abstract.
  116. Pecorari, M., Villano, D., Testa, M. F., Schmid, M., and Serafini, M. Biomarkers of antioxidant status following ingestion of green teas at different polyphenol concentrations and antioxidant capacity in human volunteers. Mol.Nutr.Food Res. 2010;54 Suppl 2:S278-S283. View abstract.
  117. Ichinose, T., Nomura, S., Someya, Y., Akimoto, S., Tachiyashiki, K., and Imaizumi, K. Effect of endurance training supplemented with green tea extract on substrate metabolism during exercise in humans. Scand.J Med Sci.Sports 3-10-2010; View abstract.
  118. Malhomme, de la Roche, Seagrove, S., Mehta, A., Divekar, P., Campbell, S., and Curnow, A. Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion. J Photochem.Photobiol.B 4-20-2010; View abstract.
  119. Myers, S. P., Stevenson, L., Cheras, P. A., O'Connor, J., Brooks, L., Rolfe, M., Conellan, P., and Morris, C. A forced titration study of the antioxidant and immunomodulatory effects of Ambrotose AO supplement. BMC.Complement Altern.Med 2010;10:16. View abstract.
  120. Chuarienthong, P., Lourith, N., and Leelapornpisid, P. Clinical efficacy comparison of anti-wrinkle cosmetics containing herbal flavonoids. Int J Cosmet.Sci. 2010;32:99-106. View abstract.
  121. Bieschke, J., Russ, J., Friedrich, R. P., Ehrnhoefer, D. E., Wobst, H., Neugebauer, K., and Wanker, E. E. EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity. Proc.Natl.Acad.Sci.U.S.A 4-27-2010;107:7710-7715. View abstract.
  122. Chan, C. M., Huang, J. H., Chiang, H. S., Wu, W. B., Lin, H. H., Hong, J. Y., and Hung, C. F. Effects of (-)-epigallocatechin gallate on RPE cell migration and adhesion. Mol.Vis. 2010;16:586-595. View abstract.
  123. Dominiak, K., McKinney, J., Heilbrun, L. K., and Sarkar, F. H. Critical need for clinical trials: an example of a pilot human intervention trial of a mixture of natural agents protecting lymphocytes against TNF-alpha induced activation of NF-kappaB. Pharm.Res. 2010;27:1061-1065. View abstract.
  124. Thielecke, F., Rahn, G., Bohnke, J., Adams, F., Birkenfeld, A. L., Jordan, J., and Boschmann, M. Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study. Eur.J Clin Nutr 2010;64:704-713. View abstract.
  125. Liatsos, G. D., Moulakakis, A., Ketikoglou, I., and Klonari, S. Possible green tea-induced thrombotic thrombocytopenic purpura. Am.J Health Syst.Pharm. 4-1-2010;67:531-534. View abstract.
  126. Pavel, L. and Pave, S. [Usefulness of micronutrients in the treatment of periodontitis]. Ned.Tijdschr.Tandheelkd. 2010;117:103-106. View abstract.
  127. Ahmed, K., Wei, Z. L., Zhao, Q. L., Nakajima, N., Matsunaga, T., Ogasawara, M., and Kondo, T. Role of fatty acid chain length on the induction of apoptosis by newly synthesized catechin derivatives. Chem.Biol.Interact. 5-14-2010;185:182-188. View abstract.
  128. Kato, M. T., Leite, A. L., Hannas, A. R., and Buzalaf, M. A. Gels containing MMP inhibitors prevent dental erosion in situ. J Dent.Res. 2010;89:468-472. View abstract.
  129. Borgovan, T., Bellistri, J. P., Slack, K. N., Kopelovich, L., Desai, M., and Joe, A. K. Inhibition of BCL2 expression and activity increases H460 sensitivity to the growth inhibitory effects of polyphenon E. J Exp Ther.Oncol. 2009;8:129-144. View abstract.
  130. Bakker, G. C., van Erk, M. J., Pellis, L., Wopereis, S., Rubingh, C. M., Cnubben, N. H., Kooistra, T., van, Ommen B., and Hendriks, H. F. An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am.J Clin Nutr. 2010;91:1044-1059. View abstract.
  131. Hirao, K., Yumoto, H., Nakanishi, T., Mukai, K., Takahashi, K., Takegawa, D., and Matsuo, T. Tea catechins reduce inflammatory reactions via mitogen-activated protein kinase pathways in toll-like receptor 2 ligand-stimulated dental pulp cells. Life Sci. 4-24-2010;86(17-18):654-660. View abstract.
  132. Li, G. X., Chen, Y. K., Hou, Z., Xiao, H., Jin, H., Lu, G., Lee, M. J., Liu, B., Guan, F., Yang, Z., Yu, A., and Yang, C. S. Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. Carcinogenesis 2010;31:902-910. View abstract.
  133. Persson, I. A., Persson, K., Hagg, S., and Andersson, R. G. Effects of green tea, black tea and Rooibos tea on angiotensin-converting enzyme and nitric oxide in healthy volunteers. Public Health Nutr. 2010;13:730-737. View abstract.
  134. Lee, J. I., Cho, B. K., Ock, S. M., and Park, H. J. Pigmented contact cheilitis: from green tea? Contact Dermatitis 2010;62:60-61. View abstract.
  135. Oyama, J., Maeda, T., Kouzuma, K., Ochiai, R., Tokimitsu, I., Higuchi, Y., Sugano, M., and Makino, N. Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers. Circ.J 2010;74:578-588. View abstract.
  136. Hatano, B., Kojima, A., Sata, T., and Katano, H. Virus detection using Viro-Adembeads, a rapid capture system for viruses, and plaque assay in intentionally virus-contaminated beverages. Jpn.J Infect.Dis. 2010;63:52-54. View abstract.
  137. Grove, K. A. and Lambert, J. D. Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity. J Nutr. 2010;140:446-453. View abstract.
  138. Mullen, W., Borges, G., Lean, M. E., Roberts, S. A., and Crozier, A. Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink. J Agric.Food Chem. 2-24-2010;58:2586-2595. View abstract.
  139. Del, Rio D., Calani, L., Cordero, C., Salvatore, S., Pellegrini, N., and Brighenti, F. Bioavailability and catabolism of green tea flavan-3-ols in humans. Nutrition 1-14-2010; View abstract.
  140. Kurita, I., Maeda-Yamamoto, M., Tachibana, H., and Kamei, M. Antihypertensive effect of Benifuuki tea containing O-methylated EGCG. J Agric.Food Chem. 2-10-2010;58:1903-1908. View abstract.
  141. Rizvi, S. I., Jha, R., and Pandey, K. B. Activation of erythrocyte plasma membrane redox system provides a useful method to evaluate antioxidant potential of plant polyphenols. Methods Mol.Biol. 2010;594:341-348. View abstract.
  142. Kuriyama, S. Green tea consumption and prevention of coronary artery disease. Circ.J 2010;74:248-249. View abstract.
  143. Annaba, F., Kumar, P., Dudeja, A. K., Saksena, S., Gill, R. K., and Alrefai, W. A. Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT. Am.J Physiol Gastrointest.Liver Physiol 2010;298:G467-G473. View abstract.
  144. Luczaj, W., Zapora, E., Szczepanski, M., Wnuczko, K., and Skrzydlewska, E. Polyphenols action against oxidative stress formation in endothelial cells. Acta Pol.Pharm. 2009;66:617-624. View abstract.
  145. Huo, C., Yang, H., Cui, Q. C., Dou, Q. P., and Chan, T. H. Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs. Bioorg.Med Chem. 2010;18:1252-1258. View abstract.
  146. Chao, J., Lau, W. K., Huie, M. J., Ho, Y. S., Yu, M. S., Lai, C. S., Wang, M., Yuen, W. H., Lam, W. H., Chan, T. H., and Chang, R. C. A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neurosci.Lett. 1-29-2010;469:360-364. View abstract.
  147. Nicholson, S. K., Tucker, G. A., and Brameld, J. M. Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br.J Nutr. 2010;103:1398-1403. View abstract.
  148. Wang, Q. M., Gong, Q. Y., Yan, J. J., Zhu, J., Tang, J. J., Wang, M. W., Yang, Z. J., and Wang, L. S. Association between green tea intake and coronary artery disease in a Chinese population. Circ.J 2010;74:294-300. View abstract.
  149. Braidy, N., Grant, R., Adams, S., and Guillemin, G. J. Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons. FEBS J 2010;277:368-382. View abstract.
  150. Klass, B. R., Branford, O. A., Grobbelaar, A. O., and Rolfe, K. J. The effect of epigallocatechin-3-gallate, a constituent of green tea, on transforming growth factor-beta1-stimulated wound contraction. Wound.Repair Regen. 2010;18:80-88. View abstract.
  151. Mineharu, Y., Koizumi, A., Wada, Y., Iso, H., Watanabe, Y., Date, C., Yamamoto, A., Kikuchi, S., Inaba, Y., Toyoshima, H., Kondo, T., and Tamakoshi, A. Coffee, green tea, black tea and oolong tea consumption and risk of mortality from cardiovascular disease in Japanese men and women. J Epidemiol.Community Health 7-14-2010; View abstract.
  152. Park, C. S., Kim, W., Woo, J. S., Ha, S. J., Kang, W. Y., Hwang, S. H., Park, Y. W., Kim, Y. S., Ahn, Y. K., Jeong, M. H., and Kim, W. Green tea consumption improves endothelial function but not circulating endothelial progenitor cells in patients with chronic renal failure. Int J Cardiol. 12-2-2009; View abstract.
  153. Hemelt, M., Hu, Z., Zhong, Z., Xie, L. P., Wong, Y. C., Tam, P. C., Cheng, K. K., Ye, Z., Bi, X., Lu, Q., Mao, Y., Zhong, W. D., and Zeegers, M. P. Fluid intake and the risk of bladder cancer: results from the South and East China case-control study on bladder cancer. Int.J.Cancer 8-1-2010;127:638-645. View abstract.
  154. Melgarejo, E., Urdiales, J. L., Sanchez-Jimenez, F., and Medina, M. A. Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate. Amino.Acids 2010;38:519-523. View abstract.
  155. Wu, Y. J., Liang, C. H., Zhou, F. J., Gao, X., Chen, L. W., and Liu, Q. [A case-control study of environmental and genetic factors and prostate cancer in Guangdong]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2009;43:581-585. View abstract.
  156. Richards, J. C., Lonac, M. C., Johnson, T. K., Schweder, M. M., and Bell, C. Epigallocatechin-3-gallate Increases Maximal Oxygen Uptake in Adult Humans. Med Sci.Sports Exerc. 11-27-2009; View abstract.
  157. Langley, P. C. A cost-effectiveness analysis of sinecatechins in the treatment of external genital warts. J.Med.Econ. 2010;13:1-7. View abstract.
  158. Cheng, C. W., Shieh, P. C., Lin, Y. C., Chen, Y. J., Lin, Y. H., Kuo, D. H., Liu, J. Y., Kao, J. Y., Kao, M. C., and Way, T. D. Indoleamine 2,3-dioxygenase, an immunomodulatory protein, is suppressed by (-)-epigallocatechin-3-gallate via blocking of gamma-interferon-induced JAK-PKC-delta-STAT1 signaling in human oral cancer cells. J Agric.Food Chem. 1-27-2010;58:887-894. View abstract.
  159. Melgarejo, E., Medina, M. A., Sanchez-Jimenez, F., and Urdiales, J. L. Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro. Br.J Pharmacol. 2009;158:1705-1712. View abstract.
  160. Agarwal, A., Prasad, R., and Jain, A. Effect of green tea extract (catechins) in reducing oxidative stress seen in patients of pulmonary tuberculosis on DOTS Cat I regimen. Phytomedicine. 2010;17:23-27. View abstract.
  161. Korte, G., Dreiseitel, A., Schreier, P., Oehme, A., Locher, S., Geiger, S., Heilmann, J., and Sand, P. G. Tea catechins' affinity for human cannabinoid receptors. Phytomedicine. 2010;17:19-22. View abstract.
  162. Cardoso, M. H., Morganti, R. P., Lilla, S., Murad, F., De, Nucci G., Antunes, E., and Marcondes, S. The role of superoxide anion in the inhibitory effect of SIN-1 in thrombin-activated human platelet adhesion. Eur.J.Pharmacol. 2-10-2010;627(1-3):229-234. View abstract.
  163. Das, A., Banik, N. L., and Ray, S. K. Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes. Cancer 1-1-2010;116:164-176. View abstract.
  164. Tsao, A. S., Liu, D., Martin, J., Tang, X. M., Lee, J. J., El-Naggar, A. K., Wistuba, I., Culotta, K. S., Mao, L., Gillenwater, A., Sagesaka, Y. M., Hong, W. K., and Papadimitrakopoulou, V. Phase II randomized, placebo-controlled trial of green tea extract in patients with high-risk oral premalignant lesions. Cancer Prev.Res.(Phila Pa) 2009;2:931-941. View abstract.
  165. Shin, D. M. Oral cancer prevention advances with a translational trial of green tea. Cancer Prev.Res.(Phila Pa) 2009;2:919-921. View abstract.
  166. Reiter, C. E., Kim, J. A., and Quon, M. J. Green tea polyphenol epigallocatechin gallate reduces endothelin-1 expression and secretion in vascular endothelial cells: roles for AMP-activated protein kinase, Akt, and FOXO1. Endocrinology 2010;151:103-114. View abstract.
  167. Ishii, K., Tanaka, S., Kagami, K., Henmi, K., Toyoda, H., Kaise, T., and Hirano, T. Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. Cancer Invest 2010;28:220-229. View abstract.
  168. Ferreira, N., Cardoso, I., Domingues, M. R., Vitorino, R., Bastos, M., Bai, G., Saraiva, M. J., and Almeida, M. R. Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity. FEBS Lett. 11-19-2009;583:3569-3576. View abstract.
  169. McGowan, M. P. and Proulx, S. Nutritional supplements and serum lipids: does anything work? Curr.Atheroscler.Rep. 2009;11:470-476. View abstract.
  170. Evans, S., Dizeyi, N., Abrahamsson, P. A., and Persson, J. The effect of a novel botanical agent TBS-101 on invasive prostate cancer in animal models. Anticancer Res 2009;29:3917-3924. View abstract.
  171. Eichenberger, P., Colombani, P. C., and Mettler, S. Effects of 3-week consumption of green tea extracts on whole-body metabolism during cycling exercise in endurance-trained men. Int J Vitam.Nutr.Res. 2009;79:24-33. View abstract.
  172. Batista, Gde A., Cunha, C. L., Scartezini, M., von der, Heyde R., Bitencourt, M. G., and Melo, S. F. Prospective double-blind crossover study of Camellia sinensis (green tea) in dyslipidemias. Arq Bras.Cardiol. 2009;93:128-134. View abstract.
  173. Fenercioglu, A. K., Saler, T., Genc, E., Sabuncu, H., and Altuntas, Y. The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications. J Endocrinol.Invest 2010;33:118-124. View abstract.
  174. Lee, Y. W., Lee, W. H., and Kim, P. H. Oxidative mechanisms of IL-4-induced IL-6 expression in vascular endothelium. Cytokine 2010;49:73-79. View abstract.
  175. Sommer, A. P. and Zhu, D. Green tea and red light--a powerful duo in skin rejuvenation. Photomed.Laser Surg. 2009;27:969-971. View abstract.
  176. Loke, W. M., Jenner, A. M., Proudfoot, J. M., McKinley, A. J., Hodgson, J. M., Halliwell, B., and Croft, K. D. A metabolite profiling approach to identify biomarkers of flavonoid intake in humans. J.Nutr. 2009;139:2309-2314. View abstract.
  177. Kondo, M., Zhang, L., Ji, H., Kou, Y., and Ou, B. Bioavailability and antioxidant effects of a xanthone-rich Mangosteen (Garcinia mangostana) product in humans. J Agric.Food Chem. 10-14-2009;57:8788-8792. View abstract.
  178. dal Belo, S. E., Gaspar, L. R., Maia Campos, P. M., and Marty, J. P. Skin penetration of epigallocatechin-3-gallate and quercetin from green tea and Ginkgo biloba extracts vehiculated in cosmetic formulations. Skin Pharmacol.Physiol 2009;22:299-304. View abstract.
  179. Tang, N. P., Li, H., Qiu, Y. L., Zhou, G. M., and Ma, J. Tea consumption and risk of endometrial cancer: a metaanalysis. Am.J Obstet.Gynecol. 2009;201:605-608. View abstract.
  180. Moore, R. J., Jackson, K. G., and Minihane, A. M. Green tea (Camellia sinensis) catechins and vascular function. Br.J Nutr. 2009;102:1790-1802. View abstract.
  181. Larsen, C. A. and Dashwood, R. H. Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide. Biochem.Biophys.Res.Commun. 11-20-2009;389:527-530. View abstract.
  182. Magalhaes, A. C., Wiegand, A., Rios, D., Hannas, A., Attin, T., and Buzalaf, M. A. Chlorhexidine and green tea extract reduce dentin erosion and abrasion in situ. J Dent. 2009;37:994-998. View abstract.
  183. Shen, C. L., Chyu, M. C., Yeh, J. K., Felton, C. K., Xu, K. T., Pence, B. C., and Wang, J. S. Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trial. BMC.Musculoskelet.Disord. 2009;10:110. View abstract.
  184. Wen, W., Xiang, Y. B., Zheng, W., Xu, W. H., Yang, G., Li, H., and Shu, X. O. The association of alcohol, tea, and other modifiable lifestyle factors with myocardial infarction and stroke in Chinese men. CVD.Prev Control 2008;3:133-140. View abstract.
  185. Okada, N., Tanabe, H., Tazoe, H., Ishigami, Y., Fukutomi, R., Yasui, K., and Isemura, M. Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells. Biomed.Res. 2009;30:201-206. View abstract.
  186. Tomankova, K., Kolarova, H., Bajgar, R., Jirova, D., Kejlova, K., and Mosinger, J. Study of the photodynamic effect on the A549 cell line by atomic force microscopy and the influence of green tea extract on the production of reactive oxygen species. Ann.N.Y.Acad.Sci. 2009;1171:549-558. View abstract.
  187. Appeldoorn, M. M., Venema, D. P., Peters, T. H., Koenen, M. E., Arts, I. C., Vincken, J. P., Gruppen, H., Keijer, J., and Hollman, P. C. Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. J Agric.Food Chem. 9-9-2009;57:7693-7699. View abstract.
  188. Kobayashi, M., Ichitani, M., Suzuki, Y., Unno, T., Sugawara, T., Yamahira, T., Kato, M., Takihara, T., Sagesaka, Y., Kakuda, T., and Ikeda, I. Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats. J Agric.Food Chem. 8-12-2009;57:7131-7136. View abstract.
  189. Sanchez, Y., Calle, C., de, Blas E., and Aller, P. Modulation of arsenic trioxide-induced apoptosis by genistein and functionally related agents in U937 human leukaemia cells. Regulation by ROS and mitogen-activated protein kinases. Chem.Biol.Interact. 11-10-2009;182:37-44. View abstract.
  190. Zhang, Z. M., Yang, X. Y., Yuan, J. H., Sun, Z. Y., and Li, Y. Q. Modulation of NRF2 and UGT1A expression by epigallocatechin-3-gallate in colon cancer cells and BALB/c mice. Chin Med J (Engl.) 7-20-2009;122:1660-1665. View abstract.
  191. Tatti, S., Stockfleth, E., Beutner, K. R., Tawfik, H., Elsasser, U., Weyrauch, P., and Mescheder, A. Polyphenon E: a new treatment for external anogenital warts. Br.J Dermatol. 2010;162:176-184. View abstract.
  192. Wang, H., Wen, Y., Du, Y., Yan, X., Guo, H., Rycroft, J. A., Boon, N., Kovacs, E. M., and Mela, D. J. Effects of catechin enriched green tea on body composition. Obesity.(Silver.Spring) 2010;18:773-779. View abstract.
  193. Roomi, M. W., Roomi, N. W., Kalinovsky, T., Rath, M., and Niedzwiecki, A. Marked inhibition of growth and invasive parameters of head and neck squamous carcinoma FaDu by a nutrient mixture. Integr.Cancer Ther. 2009;8:168-176. View abstract.
  194. Feily, A., Yaghoobi, R., and Namazi, M. R. The potential utility of green tea extract as a novel treatment for cutaneous leishmaniasis. J Altern.Complement Med 2009;15:815-816. View abstract.
  195. Eleuteri, A. M., Amici, M., Bonfili, L., Cecarini, V., Cuccioloni, M., Grimaldi, S., Giuliani, L., Angeletti, M., and Fioretti, E. 50 Hz extremely low frequency electromagnetic fields enhance protein carbonyl groups content in cancer cells: effects on proteasomal systems. J.Biomed.Biotechnol. 2009;2009:834239. View abstract.
  196. Zhang, T., Yang, D., Fan, Y., Xie, P., and Li, H. Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis. 2009;14:1245-1254. View abstract.
  197. Koeberle, A., Bauer, J., Verhoff, M., Hoffmann, M., Northoff, H., and Werz, O. Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E synthase-1. Biochem.Biophys.Res.Commun. 10-16-2009;388:350-354. View abstract.
  198. Ohga, N., Hida, K., Hida, Y., Muraki, C., Tsuchiya, K., Matsuda, K., Ohiro, Y., Totsuka, Y., and Shindoh, M. Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells. Cancer Sci. 2009;100:1963-1970. View abstract.
  199. Ma, L., Cao, T. T., Kandpal, G., Warren, L., Fred, Hess J., Seabrook, G. R., and Ray, W. J. Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson's disease alpha-synuclein A53T mutation. Neurochem.Res. 2010;35:130-142. View abstract.
  200. Milligan, S. A., Burke, P., Coleman, D. T., Bigelow, R. L., Steffan, J. J., Carroll, J. L., Williams, B. J., and Cardelli, J. A. The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells. Clin Cancer Res. 8-1-2009;15:4885-4894. View abstract.
  201. Watanabe, I., Kuriyama, S., Kakizaki, M., Sone, T., Ohmori-Matsuda, K., Nakaya, N., Hozawa, A., and Tsuji, I. Green tea and death from pneumonia in Japan: the Ohsaki cohort study. Am.J Clin Nutr. 2009;90:672-679. View abstract.
  202. Zhang, L., Cao, H., Wen, J., and Xu, M. Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. Nutr.Neurosci. 2009;12:142-148. View abstract.
  203. Di, Pierro F., Menghi, A. B., Barreca, A., Lucarelli, M., and Calandrelli, A. Greenselect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Altern.Med Rev. 2009;14:154-160. View abstract.
  204. Boehm, K., Borrelli, F., Ernst, E., Habacher, G., Hung, S. K., Milazzo, S., and Horneber, M. Green tea (Camellia sinensis) for the prevention of cancer. Cochrane.Database.Syst.Rev. 2009;:CD005004. View abstract.
  205. Kale, A., Gawande, S., Kotwal, S., Netke, S., Roomi, W., Ivanov, V., Niedzwiecki, A., and Rath, M. Studies on the effects of oral administration of nutrient mixture, quercetin and red onions on the bioavailability of epigallocatechin gallate from green tea extract. Phytother.Res. 2010;24 Suppl 1:S48-S55. View abstract.
  206. Al-Sowyan, N. S. Difference in leptin hormone response to nutritional status in normal adult male albino rats. Pak.J Biol.Sci. 1-15-2009;12:119-126. View abstract.
  207. Yao, J., Liu, Y., Wang, X., Shen, Y., Yuan, S., Wan, Y., and Jiang, Q. UVB radiation induces human lens epithelial cell migration via NADPH oxidase-mediated generation of reactive oxygen species and up-regulation of matrix metalloproteinases. Int.J.Mol.Med. 2009;24:153-159. View abstract.
  208. Adachi, S., Shimizu, M., Shirakami, Y., Yamauchi, J., Natsume, H., Matsushima-Nishiwaki, R., To, S., Weinstein, I. B., Moriwaki, H., and Kozawa, O. (-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells. Carcinogenesis 2009;30:1544-1552. View abstract.
  209. Yu, H. N., Zhang, L. C., Yang, J. G., Das, U. N., and Shen, S. R. Effect of laminin tyrosine-isoleucine-glycine-serine-arginine peptide on the growth of human prostate cancer (PC-3) cells in vitro. Eur.J.Pharmacol. 8-15-2009;616(1-3):251-255. View abstract.
  210. Snider, J. Green tea may promote periodontal health. J Am.Dent.Assoc. 2009;140:838. View abstract.
  211. Shirakami, Y., Shimizu, M., Adachi, S., Sakai, H., Nakagawa, T., Yasuda, Y., Tsurumi, H., Hara, Y., and Moriwaki, H. (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. Cancer Sci. 2009;100:1957-1962. View abstract.
  212. Maeda-Yamamoto, M., Ema, K., Monobe, M., Shibuichi, I., Shinoda, Y., Yamamoto, T., and Fujisawa, T. The efficacy of early treatment of seasonal allergic rhinitis with benifuuki green tea containing O-methylated catechin before pollen exposure: an open randomized study. Allergol.Int 2009;58:437-444. View abstract.
  213. Robertson, I. M., Li, M. X., and Sykes, B. D. Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate. J Biol.Chem. 8-21-2009;284:23012-23023. View abstract.
  214. Gao, Z., Xu, Z., Hung, M. S., Lin, Y. C., Wang, T., Gong, M., Zhi, X., Jablon, D. M., and You, L. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Res. 2009;29:2025-2030. View abstract.
  215. Aihara, Y., Yoshida, A., Furuta, T., Wakimoto, T., Akizawa, T., Konishi, M., and Kan, T. Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg.Med Chem.Lett. 8-1-2009;19:4171-4174. View abstract.
  216. Yang, H., Zonder, J. A., and Dou, Q. P. Clinical development of novel proteasome inhibitors for cancer treatment. Expert.Opin.Investig.Drugs 2009;18:957-971. View abstract.
  217. Schmitt, C. A. and Dirsch, V. M. Modulation of endothelial nitric oxide by plant-derived products. Nitric.Oxide. 2009;21:77-91. View abstract.
  218. Baumeister, P., Reiter, M., Kleinsasser, N., Matthias, C., and Harreus, U. Epigallocatechin-3-gallate reduces DNA damage induced by benzo[a]pyrene diol epoxide and cigarette smoke condensate in human mucosa tissue cultures. Eur.J Cancer Prev. 2009;18:230-235. View abstract.
  219. Shanafelt, T. D., Call, T. G., Zent, C. S., LaPlant, B., Bowen, D. A., Roos, M., Secreto, C. R., Ghosh, A. K., Kabat, B. F., Lee, M. J., Yang, C. S., Jelinek, D. F., Erlichman, C., and Kay, N. E. Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol. 8-10-2009;27:3808-3814. View abstract.
  220. Janjua, R., Munoz, C., Gorell, E., Rehmus, W., Egbert, B., Kern, D., and Chang, A. L. A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin. Dermatol.Surg. 2009;35:1057-1065. View abstract.
  221. Borawska, M. H., Czechowska, S. K., Markiewicz, R., Hayirli, A., Olszewska, E., and Sahin, K. Cell viability of normal human skin fibroblast and fibroblasts derived from granulation tissue: effects of nutraceuticals. J Med Food 2009;12:429-434. View abstract.
  222. Hauber, I., Hohenberg, H., Holstermann, B., Hunstein, W., and Hauber, J. The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection. Proc.Natl.Acad.Sci.U.S.A 6-2-2009;106:9033-9038. View abstract.
  223. Li, L., Chen, C. Y., Aldini, G., Johnson, E. J., Rasmussen, H., Yoshida, Y., Niki, E., Blumberg, J. B., Russell, R. M., and Yeum, K. J. Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults. J Nutr.Biochem. 2010;21:544-549. View abstract.
  224. Gregersen, N. T., Bitz, C., Krog-Mikkelsen, I., Hels, O., Kovacs, E. M., Rycroft, J. A., Frandsen, E., Mela, D. J., and Astrup, A. Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. Br.J Nutr. 2009;102:1187-1194. View abstract.
  225. Rasheed, Z., Anbazhagan, A. N., Akhtar, N., Ramamurthy, S., Voss, F. R., and Haqqi, T. M. Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res.Ther. 2009;11:R71. View abstract.
  226. Kalus, U., Kiesewetter, H., and Radtke, H. Effect of CYSTUS052 and green tea on subjective symptoms in patients with infection of the upper respiratory tract. Phytother.Res. 2010;24:96-100. View abstract.
  227. Ogunleye, A. A., Xue, F., and Michels, K. B. Green tea consumption and breast cancer risk or recurrence: a meta-analysis. Breast Cancer Res.Treat. 2010;119:477-484. View abstract.
  228. Kawano, T., Matsuse, H., Fukahori, S., Tsuchida, T., Fukushima, C., and Kohno, S. [Green tea-induced asthma]. Nippon Naika Gakkai Zasshi 4-10-2009;98:866-867. View abstract.
  229. Osterburg, A., Gardner, J., Hyon, S. H., Neely, A., and Babcock, G. Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG). Clin Microbiol.Infect. 2009;15:341-346. View abstract.
  230. Zhu, J., Wang, O., Ruan, L., Hou, X., Cui, Y., Wang, J. M., and Le, Y. The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR. Int Immunopharmacol. 2009;9:1126-1130. View abstract.
  231. Kushima, Y., Iida, K., Nagaoka, Y., Kawaratani, Y., Shirahama, T., Sakaguchi, M., Baba, K., Hara, Y., and Uesato, S. Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol.Pharm.Bull. 2009;32:899-904. View abstract.
  232. Richard, D., Kefi, K., Barbe, U., Poli, A., Bausero, P., and Visioli, F. Weight and plasma lipid control by decaffeinated green tea. Pharmacol.Res. 2009;59:351-354. View abstract.
  233. Han, D. H., Jeong, J. H., and Kim, J. H. Anti-proliferative and apoptosis induction activity of green tea polyphenols on human promyelocytic leukemia HL-60 cells. Anticancer Res. 2009;29:1417-1421. View abstract.
  234. Bergman, J. and Schjott, J. Hepatitis caused by Lotus-f3? Basic Clin Pharmacol.Toxicol. 2009;104:414-416. View abstract.
  235. Horiba, N., Maekawa, Y., Ito, M., Matsumoto, T., and Nakamura, H. A pilot study of Japanese green tea as a medicament: antibacterial and bactericidal effects. J Endod. 1991;17:122-124. View abstract.
  236. Chen, Y. K., Lee, C. H., Wu, I. C., Liu, J. S., Wu, D. C., Lee, J. M., Goan, Y. G., Chou, S. H., Huang, C. T., Lee, C. Y., Hung, H. C., Yang, J. F., and Wu, M. T. Food intake and the occurrence of squamous cell carcinoma in different sections of the esophagus in Taiwanese men. Nutrition 2009;25(7-8):753-761. View abstract.
  237. Hannig, C., Sorg, J., Spitzmuller, B., Hannig, M., and Al-Ahmad, A. Polyphenolic beverages reduce initial bacterial adherence to enamel in situ. J Dent. 2009;37:560-566. View abstract.
  238. Jimenez-Saenz, M., Martinez-Sanchez, Mdel C., and Herrerias-Gutierrez, J. M. [Toxic hepatitis due to Camellia sinensis: an emerging problem]. Gastroenterol.Hepatol. 2009;32:321. View abstract.
  239. Kaufmann, R., Henklein, P., Henklein, P., and Settmacher, U. Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation. Oncol.Rep. 2009;21:1261-1267. View abstract.
  240. Figueiroa, M. S., Cesar Vieira, J. S., Leite, D. S., Filho, R. C., Ferreira, F., Gouveia, P. S., Udrisar, D. P., and Wanderley, M. I. Green tea polyphenols inhibit testosterone production in rat Leydig cells. Asian J Androl 2009;11:362-370. View abstract.
  241. Dann, J. M., Sykes, P. H., Mason, D. R., and Evans, J. J. Regulation of Vascular Endothelial Growth Factor in endometrial tumour cells by resveratrol and EGCG. Gynecol.Oncol. 2009;113:374-378. View abstract.
  242. Costa, R. M., Magalhaes, A. S., Pereira, J. A., Andrade, P. B., Valentao, P., Carvalho, M., and Silva, B. M. Evaluation of free radical-scavenging and antihemolytic activities of quince (Cydonia oblonga) leaf: a comparative study with green tea (Camellia sinensis). Food Chem.Toxicol. 2009;47:860-865. View abstract.
  243. Tsang, W. P. and Kwok, T. T. Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J Nutr.Biochem. 2010;21:140-146. View abstract.
  244. de Mejia, E. G., Ramirez-Mares, M. V., and Puangpraphant, S. Bioactive components of tea: cancer, inflammation and behavior. Brain Behav.Immun. 2009;23:721-731. View abstract.
  245. Kushiyama, M., Shimazaki, Y., Murakami, M., and Yamashita, Y. Relationship between intake of green tea and periodontal disease. J Periodontol. 2009;80:372-377. View abstract.
  246. Lang, M., Henson, R., Braconi, C., and Patel, T. Epigallocatechin-gallate modulates chemotherapy-induced apoptosis in human cholangiocarcinoma cells. Liver Int 2009;29:670-677. View abstract.
  247. Huang, X., Kojima-Yuasa, A., Xu, S., Kennedy, D. O., Hasuma, T., and Matsui-Yuasa, I. Combination of Zizyphus jujuba and green tea extracts exerts excellent cytotoxic activity in HepG2 cells via reducing the expression of APRIL. Am.J Chin Med 2009;37:169-179. View abstract.
  248. Wang, L., Xu, S., Xu, X., and Chan, P. (-)-Epigallocatechin-3-Gallate protects SH-SY5Y cells against 6-OHDA-induced cell death through STAT3 activation. J.Alzheimers.Dis. 2009;17:295-304. View abstract.
  249. Nance, C. L., Siwak, E. B., and Shearer, W. T. Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy. J Allergy Clin Immunol. 2009;123:459-465. View abstract.
  250. Hong, Y. H., Lim, G. O., and Song, K. B. Physical properties of Gelidium corneum-gelatin blend films containing grapefruit seed extract or green tea extract and its application in the packaging of pork loins. J Food Sci. 2009;74:C6-C10. View abstract.
  251. Shin, B. C., Ryu, H. H., Chung, J. H., Lee, B. R., and Kim, H. L. The protective effects of green tea extract against L-arginine toxicity to cultured human mesangial cells. J Korean Med.Sci. 2009;24 Suppl:S204-S209. View abstract.
  252. Fukushima, Y., Ohie, T., Yonekawa, Y., Yonemoto, K., Aizawa, H., Mori, Y., Watanabe, M., Takeuchi, M., Hasegawa, M., Taguchi, C., and Kondo, K. Coffee and green tea as a large source of antioxidant polyphenols in the Japanese population. J Agric.Food Chem. 2-25-2009;57:1253-1259. View abstract.
  253. Nozaki, A., Hori, M., Kimura, T., Ito, H., and Hatano, T. Interaction of polyphenols with proteins: binding of (-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism. Chem.Pharm.Bull.(Tokyo) 2009;57:224-228. View abstract.
  254. Engdal, S. and Nilsen, O. G. In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients. Phytother.Res. 2009;23:906-912. View abstract.
  255. Lee, Y. L., Hong, C. Y., Kok, S. H., Hou, K. L., Lin, Y. T., Chen, M. H., Wang, C. C., and Lin, S. K. An extract of green tea, epigallocatechin-3-gallate, reduces periapical lesions by inhibiting cysteine-rich 61 expression in osteoblasts. J Endod. 2009;35:206-211. View abstract.
  256. Song, S., Krishnan, K., Liu, K., and Bresalier, R. S. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clin Cancer Res. 1-15-2009;15:622-631. View abstract.
  257. Choi, K. C., Jung, M. G., Lee, Y. H., Yoon, J. C., Kwon, S. H., Kang, H. B., Kim, M. J., Cha, J. H., Kim, Y. J., Jun, W. J., Lee, J. M., and Yoon, H. G. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res. 1-15-2009;69:583-592. View abstract.
  258. Lu, Q. Y., Yang, Y., Jin, Y. S., Zhang, Z. F., Heber, D., Li, F. P., Dubinett, S. M., Sondej, M. A., Loo, J. A., and Rao, J. Y. Effects of green tea extract on lung cancer A549 cells: proteomic identification of proteins associated with cell migration. Proteomics. 2009;9:757-767. View abstract.
  259. Wu, H., Zhu, B., Shimoishi, Y., Murata, Y., and Nakamura, Y. (-)-Epigallocatechin-3-gallate induces up-regulation of Th1 and Th2 cytokine genes in Jurkat T cells. Arch.Biochem.Biophys. 3-1-2009;483:99-105. View abstract.
  260. Tang, N., Wu, Y., Zhou, B., Wang, B., and Yu, R. Green tea, black tea consumption and risk of lung cancer: a meta-analysis. Lung Cancer 2009;65:274-283. View abstract.
  261. Wu, M., Liu, A. M., Kampman, E., Zhang, Z. F., Van't Veer, P., Wu, D. L., Wang, P. H., Yang, J., Qin, Y., Mu, L. N., Kok, F. J., and Zhao, J. K. Green tea drinking, high tea temperature and esophageal cancer in high- and low-risk areas of Jiangsu Province, China: a population-based case-control study. Int J Cancer 4-15-2009;124:1907-1913. View abstract.
  262. Nagai, M., Fukamachi, T., Tsujimoto, M., Ogura, K., Hiratsuka, A., Ohtani, H., Hori, S., and Sawada, Y. Inhibitory effects of herbal extracts on the activity of human sulfotransferase isoform sulfotransferase 1A3 (SULT1A3). Biol Pharm Bull 2009;32:105-109. View abstract.
  263. Yin, Z., Henry, E. C., and Gasiewicz, T. A. (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. Biochemistry 1-20-2009;48:336-345. View abstract.
  264. Basu, A. and Haldar, S. Combinatorial effect of epigallocatechin-3-gallate and TRAIL on pancreatic cancer cell death. Int J Oncol. 2009;34:281-286. View abstract.
  265. Shrubsole, M. J., Lu, W., Chen, Z., Shu, X. O., Zheng, Y., Dai, Q., Cai, Q., Gu, K., Ruan, Z. X., Gao, Y. T., and Zheng, W. Drinking green tea modestly reduces breast cancer risk. J Nutr. 2009;139:310-316. View abstract.
  266. Kurahashi, N., Inoue, M., Iwasaki, M., Sasazuki, S., and Tsugane, S. Coffee, green tea, and caffeine consumption and subsequent risk of bladder cancer in relation to smoking status: a prospective study in Japan. Cancer Sci. 2009;100:294-91. View abstract.
  267. Kakuta, Y., Nakaya, N., Nagase, S., Fujita, M., Koizumi, T., Okamura, C., Niikura, H., Ohmori, K., Kuriyama, S., Tase, T., Ito, K., Minami, Y., Yaegashi, N., and Tsuji, I. Case-control study of green tea consumption and the risk of endometrial endometrioid adenocarcinoma. Cancer Causes Control 2009;20:617-624. View abstract.
  268. Zhang, M., Huang, J., Xie, X., and Holman, C. D. Dietary intakes of mushrooms and green tea combine to reduce the risk of breast cancer in Chinese women. Int J Cancer 3-15-2009;124:1404-1408. View abstract.
  269. Mandel, S. A., Amit, T., Weinreb, O., Reznichenko, L., and Youdim, M. B. Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases. CNS.Neurosci.Ther. 2008;14:352-365. View abstract.
  270. Meltzer, S. M., Monk, B. J., and Tewari, K. S. Green tea catechins for treatment of external genital warts. Am J Obstet.Gynecol. 2009;200:233-237. View abstract.
  271. Yang, C. S., Lambert, J. D., and Sang, S. Antioxidative and anti-carcinogenic activities of tea polyphenols. Arch.Toxicol. 2009;83:11-21. View abstract.
  272. Shimizu, M., Fukutomi, Y., Ninomiya, M., Nagura, K., Kato, T., Araki, H., Suganuma, M., Fujiki, H., and Moriwaki, H. Green tea extracts for the prevention of metachronous colorectal adenomas: a pilot study. Cancer Epidemiol.Biomarkers Prev. 2008;17:3020-3025. View abstract.
  273. Myung, S. K., Bae, W. K., Oh, S. M., Kim, Y., Ju, W., Sung, J., Lee, Y. J., Ko, J. A., Song, J. I., and Choi, H. J. Green tea consumption and risk of stomach cancer: a meta-analysis of epidemiologic studies. Int J Cancer 2-1-2009;124:670-677. View abstract.
  274. Lee, S. Y., Shin, Y. W., and Hahm, K. B. Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection. J Dig.Dis 2008;9:129-139. View abstract.
  275. Mandel, S. A., Amit, T., Kalfon, L., Reznichenko, L., Weinreb, O., and Youdim, M. B. Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG). J Alzheimers.Dis. 2008;15:211-222. View abstract.
  276. Shin, D. W., Kim, S. N., Lee, S. M., Lee, W., Song, M. J., Park, S. M., Lee, T. R., Baik, J. H., Kim, H. K., Hong, J. H., and Noh, M. (-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPAR gamma transactivation. Biochem.Pharmacol. 1-1-2009;77:125-133. View abstract.
  277. Thomas, F., Patel, S., Holly, J. M., Persad, R., Bahl, A., and Perks, C. M. Dihydrotestosterone sensitises LNCaP cells to death induced by epigallocatechin-3-Gallate (EGCG) or an IGF-I receptor inhibitor. Prostate 2-1-2009;69:219-224. View abstract.
  278. Korkina, L. G., Pastore, S., De, Luca C., and Kostyuk, V. A. Metabolism of plant polyphenols in the skin: beneficial versus deleterious effects. Curr.Drug Metab 2008;9:710-729. View abstract.
  279. Nantz, M. P., Rowe, C. A., Bukowski, J. F., and Percival, S. S. Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study. Nutrition 2009;25:147-154. View abstract.
  280. Maurya, P. K. and Rizvi, S. I. Protective role of tea catechins on erythrocytes subjected to oxidative stress during human aging. Nat.Prod.Res. 2009;23:1072-1079. View abstract.
  281. Jochmann, N., Baumann, G., and Stangl, V. Green tea and cardiovascular disease: from molecular targets towards human health. Curr.Opin.Clin Nutr.Metab Care 2008;11:758-765. View abstract.
  282. Yung, L. M., Leung, F. P., Wong, W. T., Tian, X. Y., Yung, L. H., Chen, Z. Y., Yao, X. Q., and Huang, Y. Tea polyphenols benefit vascular function. Inflammopharmacology. 2008;16:230-234. View abstract.
  283. Huo, C., Wan, S. B., Lam, W. H., Li, L., Wang, Z., Landis-Piwowar, K. R., Chen, D., Dou, Q. P., and Chan, T. H. The challenge of developing green tea polyphenols as therapeutic agents. Inflammopharmacology. 2008;16:248-252. View abstract.
  284. Tachibana, H. Green tea polyphenol EGCG signaling pathway through the 67-kDa laminin receptor. Nippon Yakurigaku Zasshi 2008;132:145-149. View abstract.
  285. Kuo, Y. C., Yu, C. L., Liu, C. Y., Wang, S. F., Pan, P. C., Wu, M. T., Ho, C. K., Lo, Y. S., Li, Y., and Christiani, D. C. A population-based, case-control study of green tea consumption and leukemia risk in southwestern Taiwan. Cancer Causes Control 2009;20:57-65. View abstract.
  286. Papparella, I., Ceolotto, G., Montemurro, D., Antonello, M., Garbisa, S., Rossi, G., and Semplicini, A. Green tea attenuates angiotensin II-induced cardiac hypertrophy in rats by modulating reactive oxygen species production and the Src/epidermal growth factor receptor/Akt signaling pathway. J Nutr. 2008;138:1596-1601. View abstract.
  287. Brown, A. L., Lane, J., Coverly, J., Stocks, J., Jackson, S., Stephen, A., Bluck, L., Coward, A., and Hendrickx, H. Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br.J Nutr. 2009;101:886-894. View abstract.
  288. Smits, P., Corstens, F. H., Aengevaeren, W. R., Wackers, F. J., and Thien, T. False-negative dipyridamole-thallium-201 myocardial imaging after caffeine infusion. J Nucl.Med. 1991;32:1538-1541. View abstract.
  289. Babu, P. V. and Liu, D. Green tea catechins and cardiovascular health: an update. Curr.Med Chem. 2008;15:1840-1850. View abstract.
  290. Inoue, M., Robien, K., Wang, R., Van Den Berg, D. J., Koh, W. P., and Yu, M. C. Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. Carcinogenesis 2008;29:1967-1972. View abstract.
  291. Zheng, Y., Lim, E. J., Wang, L., Smart, E. J., Toborek, M., and Hennig, B. Role of caveolin-1 in EGCG-mediated protection against linoleic-acid-induced endothelial cell activation. J.Nutr.Biochem. 2009;20:202-209. View abstract.
  292. Hakim, I. A., Chow, H. H., and Harris, R. B. Green tea consumption is associated with decreased DNA damage among GSTM1-positive smokers regardless of their hOGG1 genotype. J Nutr. 2008;138:1567S-1571S. View abstract.
  293. Arts, I. C. A review of the epidemiological evidence on tea, flavonoids, and lung cancer. J Nutr. 2008;138:1561S-1566S. View abstract.
  294. Kuriyama, S. The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies. J Nutr. 2008;138:1548S-1553S. View abstract.
  295. Auger, C., Mullen, W., Hara, Y., and Crozier, A. Bioavailability of polyphenon E flavan-3-ols in humans with an ileostomy. J Nutr. 2008;138:1535S-1542S. View abstract.
  296. Mnich, C. D., Hoek, K. S., Virkki, L. V., Farkas, A., Dudli, C., Laine, E., Urosevic, M., and Dummer, R. Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls. Exp Dermatol. 2009;18:69-77. View abstract.
  297. Rondanelli, M., Opizzi, A., Solerte, S. B., Trotti, R., Klersy, C., and Cazzola, R. Administration of a dietary supplement ( N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled trial. Br.J.Nutr. 2009;101:457-464. View abstract.
  298. Lin, Y., Kikuchi, S., Tamakoshi, A., Yagyu, K., Obata, Y., Kurosawa, M., Inaba, Y., Kawamura, T., Motohashi, Y., and Ishibashi, T. Green tea consumption and the risk of pancreatic cancer in Japanese adults. Pancreas 2008;37:25-30. View abstract.
  299. Engdal, S. and Nilsen, O. G. Inhibition of P-glycoprotein in Caco-2 cells: effects of herbal remedies frequently used by cancer patients. Xenobiotica 2008;38:559-573. View abstract.
  300. Singh, M., Arseneault, M., Sanderson, T., Murthy, V., and Ramassamy, C. Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms. J Agric.Food Chem. 7-9-2008;56:4855-4873. View abstract.
  301. Alemdaroglu, N. C., Dietz, U., Wolffram, S., Spahn-Langguth, H., and Langguth, P. Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: potential risk of diminished folic acid bioavailability. Biopharm.Drug Dispos. 2008;29:335-348. View abstract.
  302. Kim, J. A. Mechanisms underlying beneficial health effects of tea catechins to improve insulin resistance and endothelial dysfunction. Endocr.Metab Immune.Disord.Drug Targets. 2008;8:82-88. View abstract.
  303. Yang, H., Landis-Piwowar, K. R., Chen, D., Milacic, V., and Dou, Q. P. Natural compounds with proteasome inhibitory activity for cancer prevention and treatment. Curr.Protein Pept.Sci. 2008;9:227-239. View abstract.
  304. Alexopoulos, N., Vlachopoulos, C., Aznaouridis, K., Baou, K., Vasiliadou, C., Pietri, P., Xaplanteris, P., Stefanadi, E., and Stefanadis, C. The acute effect of green tea consumption on endothelial function in healthy individuals. Eur.J Cardiovasc.Prev.Rehabil. 2008;15:300-305. View abstract.
  305. Tatti, S., Swinehart, J. M., Thielert, C., Tawfik, H., Mescheder, A., and Beutner, K. R. Sinecatechins, a defined green tea extract, in the treatment of external anogenital warts: a randomized controlled trial. Obstet.Gynecol. 2008;111:1371-1379. View abstract.
  306. Sarma, D. N., Barrett, M. L., Chavez, M. L., Gardiner, P., Ko, R., Mahady, G. B., Marles, R. J., Pellicore, L. S., Giancaspro, G. I., and Low, Dog T. Safety of green tea extracts : a systematic review by the US Pharmacopeia. Drug Saf 2008;31:469-484. View abstract.
  307. Jin, X., Zheng, R. H., and Li, Y. M. Green tea consumption and liver disease: a systematic review. Liver Int 2008;28:990-996. View abstract.
  308. Han, D. W., Hyon, S. H., Park, J. C., Park, K. D., Park, Y. H., and Park, H. K. Non-frozen preservation of mammalian tissue using green tea polyphenolic compounds. Biomed.Mater. 2006;1:R18-R29. View abstract.
  309. Devika, P. T. and Stanely Mainzen, Prince P. (-)Epigallocatechin-gallate (EGCG) prevents mitochondrial damage in isoproterenol-induced cardiac toxicity in albino Wistar rats: a transmission electron microscopic and in vitro study. Pharmacol.Res. 2008;57:351-357. View abstract.
  310. Bertipaglia de Santana, M., Mandarino, M. G., Cardoso, J. R., Dichi, I., Dichi, J. B., Camargo, A. E., Fabris, B. A., Rodrigues, R. J., Fatel, E. C., Nixdorf, S. L., Simao, A. N., Cecchini, R., and Barbosa, D. S. Association between soy and green tea (Camellia sinensis) diminishes hypercholesterolemia and increases total plasma antioxidant potential in dyslipidemic subjects. Nutrition 2008;24:562-568. View abstract.
  311. Gawande, S., Kale, A., and Kotwal, S. Effect of nutrient mixture and black grapes on the pharmacokinetics of orally administered (-)epigallocatechin-3-gallate from green tea extract: a human study. Phytother.Res. 2008;22:802-808. View abstract.
  312. Zhou, Y., Li, N., Zhuang, W., Liu, G., Wu, T., Yao, X., Du, L., Wei, M., and Wu, X. Green tea and gastric cancer risk: meta-analysis of epidemiologic studies. Asia Pac.J Clin Nutr. 2008;17:159-165. View abstract.
  313. Panza, V. S., Wazlawik, E., Ricardo, Schutz G., Comin, L., Hecht, K. C., and da Silva, E. L. Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition 2008;24:433-442. View abstract.
  314. Venables, M. C., Hulston, C. J., Cox, H. R., and Jeukendrup, A. E. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am.J Clin Nutr. 2008;87:778-784. View abstract.
  315. Puch, F., Samson-Villeger, S., Guyonnet, D., Blachon, J. L., Rawlings, A. V., and Lassel, T. Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. Exp.Dermatol 2008;17:668-674. View abstract.
  316. Ikeda, I. Multifunctional effects of green tea catechins on prevention of the metabolic syndrome. Asia Pac.J Clin Nutr. 2008;17 Suppl 1:273-274. View abstract.
  317. Bishnu, A., Chakrabarti, K., Chakraborty, A., and Saha, T. Pesticide residue level in tea ecosystems of Hill and Dooars regions of West Bengal, India. Environ.Monit.Assess. 2009;149(1-4):457-464. View abstract.
  318. Gross, G. [Polyphenon E. A new topical therapy for condylomata acuminata]. Hautarzt 2008;59:31-35. View abstract.
  319. Inami, S., Takano, M., Yamamoto, M., Murakami, D., Tajika, K., Yodogawa, K., Yokoyama, S., Ohno, N., Ohba, T., Sano, J., Ibuki, C., Seino, Y., and Mizuno, K. Tea catechin consumption reduces circulating oxidized low-density lipoprotein. Int Heart J 2007;48:725-732. View abstract.
  320. Antonello, M., Montemurro, D., Bolognesi, M., Di, Pascoli M., Piva, A., Grego, F., Sticchi, D., Giuliani, L., Garbisa, S., and Rossi, G. P. Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts. Am.J Hypertens. 2007;20:1321-1328. View abstract.
  321. Foster, D. R., Sowinski, K. M., Chow, H. H., and Overholser, B. R. Limited sampling strategies to estimate exposure to the green tea polyphenol, epigallocatechin gallate, in fasting and fed conditions. Ther Drug Monit. 2007;29:835-842. View abstract.
  322. Hsu, J., Skover, G., and Goldman, M. P. Evaluating the efficacy in improving facial photodamage with a mixture of topical antioxidants. J Drugs Dermatol. 2007;6:1141-1148. View abstract.
  323. Rowe, C. A., Nantz, M. P., Bukowski, J. F., and Percival, S. S. Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma,delta T cell function: a randomized, double-blind, placebo-controlled study. J Am Coll.Nutr 2007;26:445-452. View abstract.
  324. Kurahashi, N., Sasazuki, S., Iwasaki, M., Inoue, M., and Tsugane, S. Green tea consumption and prostate cancer risk in Japanese men: a prospective study. Am J Epidemiol. 1-1-2008;167:71-77. View abstract.
  325. Federico, A., Tiso, A., and Loguercio, C. A case of hepatotoxicity caused by green tea. Free Radic.Biol Med 8-1-2007;43:474. View abstract.
  326. Lin, C. L., Chen, T. F., Chiu, M. J., Way, T. D., and Lin, J. K. Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation. Neurobiol.Aging 2009;30:81-92. View abstract.
  327. Ostrowska, J. and Skrzydlewska, E. The comparison of effect of catechins and green tea extract on oxidative modification of LDL in vitro. Adv Med Sci 2006;51:298-303. View abstract.
  328. Babu, P. V., Sabitha, K. E., Srinivasan, P., and Shyamaladevi, C. S. Green tea attenuates diabetes induced Maillard-type fluorescence and collagen cross-linking in the heart of streptozotocin diabetic rats. Pharmacol.Res. 2007;55:433-440. View abstract.
  329. Zhang, M., Holman, C. D., Huang, J. P., and Xie, X. Green tea and the prevention of breast cancer: a case-control study in Southeast China. Carcinogenesis 2007;28:1074-1078. View abstract.
  330. Chow, H. H., Hakim, I. A., Vining, D. R., Crowell, J. A., Cordova, C. A., Chew, W. M., Xu, M. J., Hsu, C. H., Ranger-Moore, J., and Alberts, D. S. Effects of repeated green tea catechin administration on human cytochrome P450 activity. Cancer Epidemiol.Biomarkers Prev. 2006;15:2473-2476. View abstract.
  331. Molinari, M., Watt, K. D., Kruszyna, T., Nelson, R., Walsh, M., Huang, W. Y., Nashan, B., and Peltekian, K. Acute liver failure induced by green tea extracts: case report and review of the literature. Liver Transpl. 2006;12:1892-1895. View abstract.
  332. Alemdaroglu, N. C., Wolffram, S., Boissel, J. P., Closs, E., Spahn-Langguth, H., and Langguth, P. Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells. Planta Med 2007;73:27-32. View abstract.
  333. Chan, Y. C., Hosoda, K., Tsai, C. J., Yamamoto, S., and Wang, M. F. Favorable effects of tea on reducing the cognitive deficits and brain morphological changes in senescence-accelerated mice. J Nutr.Sci.Vitaminol.(Tokyo) 2006;52:266-273. View abstract.
  334. Kim, W., Jeong, M. H., Cho, S. H., Yun, J. H., Chae, H. J., Ahn, Y. K., Lee, M. C., Cheng, X., Kondo, T., Murohara, T., and Kang, J. C. Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers. Circ.J 2006;70:1052-1057. View abstract.
  335. Martinez-Sierra, C., Rendon, Unceta P., and Martin, Herrera L. [Acute hepatitis after green tea ingestion]. Med Clin (Barc.) 6-17-2006;127:119. View abstract.
  336. Kikuchi, N., Ohmori, K., Shimazu, T., Nakaya, N., Kuriyama, S., Nishino, Y., Tsubono, Y., and Tsuji, I. No association between green tea and prostate cancer risk in Japanese men: the Ohsaki Cohort Study. Br.J Cancer 8-7-2006;95:371-373. View abstract.
  337. Javaid, A. and Bonkovsky, H. L. Hepatotoxicity due to extracts of Chinese green tea (Camellia sinensis): a growing concern. J Hepatol 2006;45:334-335. View abstract.
  338. Netsch, M. I., Gutmann, H., Schmidlin, C. B., Aydogan, C., and Drewe, J. Induction of CYP1A by green tea extract in human intestinal cell lines. Planta Med 2006;72:514-520. View abstract.
  339. Otake, S., Makimura, M., Kuroki, T., Nishihara, Y., and Hirasawa, M. Anticaries effects of polyphenolic compounds from Japanese green tea. Caries Res 1991;25:438-443. View abstract.
  340. Haque, A. M., Hashimoto, M., Katakura, M., Tanabe, Y., Hara, Y., and Shido, O. Long-term administration of green tea catechins improves spatial cognition learning ability in rats. J Nutr. 2006;136:1043-1047. View abstract.
  341. Ruhl, C. E. and Everhart, J. E. Coffee and tea consumption are associated with a lower incidence of chronic liver disease in the United States. Gastroenterology 2005;129:1928-1936. View abstract.
  342. Donovan, J. L., Devane, C. L., Chavin, K. D., Oates, J. C., Njoku, C., Patrick, K. S., Fiorini, R. N., and Markowitz, J. S. Oral administration of a decaffeinated green tea (Camellia sinensis) extract did not alter urinary 8-epi-prostaglandin F(2 alpha), a biomarker for in-vivo lipid peroxidation. J Pharm Pharmacol 2005;57:1365-1369. View abstract.
  343. Hirano-Ohmori, R., Takahashi, R., Momiyama, Y., Taniguchi, H., Yonemura, A., Tamai, S., Umegaki, K., Nakamura, H., Kondo, K., and Ohsuzu, F. Green tea consumption and serum malondialdehyde-modified LDL concentrations in healthy subjects. J Am Coll.Nutr 2005;24:342-346. View abstract.
  344. Ryu, O. H., Lee, J., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., and Choi, K. M. Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes Res.Clin Pract. 2006;71:356-358. View abstract.
  345. Slivova, V., Zaloga, G., DeMichele, S. J., Mukerji, P., Huang, Y. S., Siddiqui, R., Harvey, K., Valachovicova, T., and Sliva, D. Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells. Nutr Cancer 2005;52:66-73. View abstract.
  346. Chiu, A. E., Chan, J. L., Kern, D. G., Kohler, S., Rehmus, W. E., and Kimball, A. B. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg. 2005;31(7 Pt 2):855-860. View abstract.
  347. Sung, H., Min, W. K., Lee, W., Chun, S., Park, H., Lee, Y. W., Jang, S., and Lee, D. H. The effects of green tea ingestion over four weeks on atherosclerotic markers. Ann.Clin Biochem 2005;42(Pt 4):292-297. View abstract.
  348. Chow, H. H., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., and Alberts, D. S. Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Clin Cancer Res 6-15-2005;11:4627-4633. View abstract.
  349. Unno, T., Tago, M., Suzuki, Y., Nozawa, A., Sagesaka, Y. M., Kakuda, T., Egawa, K., and Kondo, K. Effect of tea catechins on postprandial plasma lipid responses in human subjects. Br.J Nutr. 2005;93:543-547. View abstract.
  350. Luo, H., Tang, L., Tang, M., Billam, M., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z. Q., Zhang, L., and Wang, J. S. Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine. Carcinogenesis 2006;27:262-268. View abstract.
  351. Choan, E., Segal, R., Jonker, D., Malone, S., Reaume, N., Eapen, L., and Gallant, V. A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach. Urol.Oncol. 2005;23:108-113. View abstract.
  352. Erba, D., Riso, P., Bordoni, A., Foti, P., Biagi, P. L., and Testolin, G. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J Nutr Biochem 2005;16:144-149. View abstract.
  353. Wu, A. H., Arakawa, K., Stanczyk, F. Z., Van Den, Berg D., Koh, W. P., and Yu, M. C. Tea and circulating estrogen levels in postmenopausal Chinese women in Singapore. Carcinogenesis 2005;26:976-980. View abstract.
  354. Manach, C., Williamson, G., Morand, C., Scalbert, A., and Remesy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am.J Clin Nutr. 2005;81(1 Suppl):230S-242S. View abstract.
  355. Henning, S. M., Niu, Y., Lee, N. H., Thames, G. D., Minutti, R. R., Wang, H., Go, V. L., and Heber, D. Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement. Am J Clin Nutr 2004;80:1558-1564. View abstract.
  356. Allen, N. E., Sauvaget, C., Roddam, A. W., Appleby, P., Nagano, J., Suzuki, G., Key, T. J., and Koyama, K. A prospective study of diet and prostate cancer in Japanese men. Cancer Causes Control 2004;15:911-920. View abstract.
  357. Nagaya, N., Yamamoto, H., Uematsu, M., Itoh, T., Nakagawa, K., Miyazawa, T., Kangawa, K., and Miyatake, K. Green tea reverses endothelial dysfunction in healthy smokers. Heart 2004;90:1485-1486. View abstract.
  358. Laurie, S. A., Miller, V. A., Grant, S. C., Kris, M. G., and Ng, K. K. Phase I study of green tea extract in patients with advanced lung cancer. Cancer Chemother.Pharmacol. 2005;55:33-38. View abstract.
  359. Sugiyama, T. and Sadzuka, Y. Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level. Cancer Lett. 8-30-2004;212:177-184. View abstract.
  360. Sonoda, J., Koriyama, C., Yamamoto, S., Kozako, T., Li, H. C., Lema, C., Yashiki, S., Fujiyoshi, T., Yoshinaga, M., Nagata, Y., Akiba, S., Takezaki, T., Yamada, K., and Sonoda, S. HTLV-1 provirus load in peripheral blood lymphocytes of HTLV-1 carriers is diminished by green tea drinking. Cancer Sci 2004;95:596-601. View abstract.
  361. Dell'Aica, I., Dona, M., Tonello, F., Piris, A., Mock, M., Montecucco, C., and Garbisa, S. Potent inhibitors of anthrax lethal factor from green tea. EMBO Rep. 2004;5:418-422. View abstract.
  362. Hakim, I. A., Harris, R. B., Chow, H. H., Dean, M., Brown, S., and Ali, I. U. Effect of a 4-month tea intervention on oxidative DNA damage among heavy smokers: role of glutathione S-transferase genotypes. Cancer Epidemiol.Biomarkers Prev. 2004;13:242-249. View abstract.
  363. Lee, M. J., Lambert, J. D., Prabhu, S., Meng, X., Lu, H., Maliakal, P., Ho, C. T., and Yang, C. S. Delivery of tea polyphenols to the oral cavity by green tea leaves and black tea extract. Cancer Epidemiol.Biomarkers Prev. 2004;13:132-137. View abstract.
  364. Wakai, K., Hirose, K., Takezaki, T., Hamajima, N., Ogura, Y., Nakamura, S., Hayashi, N., and Tajima, K. Foods and beverages in relation to urothelial cancer: case-control study in Japan. Int J Urol. 2004;11:11-19. View abstract.
  365. Katiyar, S. K., Agarwal, R., and Mukhtar, H. Green tea in chemoprevention of cancer. Compr.Ther 1992;18:3-8. View abstract.
  366. Hakim, I. A., Harris, R. B., Brown, S., Chow, H. H., Wiseman, S., Agarwal, S., and Talbot, W. Effect of increased tea consumption on oxidative DNA damage among smokers: a randomized controlled study. J.Nutr. 2003;133:3303S-3309S. View abstract.
  367. Mizuno, S., Watanabe, S., Nakamura, K., Omata, M., Oguchi, H., Ohashi, K., Ohyanagi, H., Fujiki, T., and Motojima, K. A multi-institute case-control study on the risk factors of developing pancreatic cancer. Jpn.J Clin Oncol. 1992;22:286-291. View abstract.
  368. Komatsu, T., Nakamori, M., Komatsu, K., Hosoda, K., Okamura, M., Toyama, K., Ishikura, Y., Sakai, T., Kunii, D., and Yamamoto, S. Oolong tea increases energy metabolism in Japanese females. J Med Invest 2003;50(3-4):170-175. View abstract.
  369. Sun J. Morning/evening menopausal formula relieves menopausal symptoms: a pilot study. J Altern Complement Med 2003;9:403-9. View abstract.
  370. Pan, T., Fei, J., Zhou, X., Jankovic, J., and Le, W. Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury. Life Sci. 1-17-2003;72:1073-1083. View abstract.
  371. Hirasawa, M., Takada, K., Makimura, M., and Otake, S. Improvement of periodontal status by green tea catechin using a local delivery system: a clinical pilot study. J Periodontal Res 2002;37:433-438. View abstract.
  372. Hirano, R., Momiyama, Y., Takahashi, R., Taniguchi, H., Kondo, K., Nakamura, H., and Ohsuzu, F. Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease. Am.J Cardiol. 11-15-2002;90:1150-1153. View abstract.
  373. Young, J. F., Dragstedt, L. O., Haraldsdottir, J., Daneshvar, B., Kal, M. A., Loft, S., Nilsson, L., Nielsen, S. E., Mayer, B., Skibsted, L. H., Huynh-Ba, T., Hermetter, A., and Sandstrom, B. Green tea extract only affects markers of oxidative status postprandially: lasting antioxidant effect of flavonoid-free diet. Br J Nutr 2002;87:343-355. View abstract.
  374. Wang, L. D., Zhou, Q., Feng, C. W., Liu, B., Qi, Y. J., Zhang, Y. R., Gao, S. S., Fan, Z. M., Zhou, Y., Yang, C. S., Wei, J. P., and Zheng, S. Intervention and follow-up on human esophageal precancerous lesions in Henan, northern China, a high-incidence area for esophageal cancer. Gan To Kagaku Ryoho 2002;29 Suppl 1:159-172. View abstract.
  375. Jodoin, J., Demeule, M., and Beliveau, R. Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim.Biophys.Acta 1-30-2002;1542(1-3):149-159. View abstract.
  376. Proniuk, S., Liederer, B. M., and Blanchard, J. Preformulation study of epigallocatechin gallate, a promising antioxidant for topical skin cancer prevention. J Pharm Sci 2002;91:111-116. View abstract.
  377. Liu, T. and Chi, Y. [Experimental study on polyphenol anti-plaque effect in human]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 2000;35:383-384. View abstract.
  378. Pan, C. Y., Kao, Y. H., and Fox, A. P. Enhancement of inward Ca currents in bovine chromaffin cells by green tea polyphenol extracts. Neurochem.Int. 2002;40:131-137. View abstract.
  379. Nagano, J., Kono, S., Preston, D. L., and Mabuchi, K. A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan). Cancer Causes Control 2001;12:501-508. View abstract.
  380. Nakachi, K., Matsuyama, S., Miyake, S., Suganuma, M., and Imai, K. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. Biofactors 2000;13(1-4):49-54. View abstract.
  381. Chow, H. H., Cai, Y., Alberts, D. S., Hakim, I., Dorr, R., Shahi, F., Crowell, J. A., Yang, C. S., and Hara, Y. Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and polyphenon E. Cancer Epidemiol.Biomarkers Prev. 2001;10:53-58. View abstract.
  382. Williams, S. N., Shih, H., Guenette, D. K., Brackney, W., Denison, M. S., Pickwell, G. V., and Quattrochi, L. C. Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. Chem Biol Interact. 11-1-2000;128:211-229. View abstract.
  383. Sasazuki, S., Kodama, H., Yoshimasu, K., Liu, Y., Washio, M., Tanaka, K., Tokunaga, S., Kono, S., Arai, H., Doi, Y., Kawano, T., Nakagaki, O., Takada, K., Koyanagi, S., Hiyamuta, K., Nii, T., Shirai, K., Ideishi, M., Arakawa, K., Mohri, M., and Takeshita, A. Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Ann.Epidemiol. 2000;10:401-408. View abstract.
  384. Zhu, M., Chen, Y., and Li, R. C. Oral absorption and bioavailability of tea catechins. Planta Med 2000;66:444-447. View abstract.
  385. August, D. A., Landau, J., Caputo, D., Hong, J., Lee, M. J., and Yang, C. S. Ingestion of green tea rapidly decreases prostaglandin E2 levels in rectal mucosa in humans. Cancer Epidemiol Biomarkers Prev 1999;8:709-713. View abstract.
  386. Nagano, J., Kono, S., Preston, D. L., Moriwaki, H., Sharp, G. B., Koyama, K., and Mabuchi, K. Bladder-cancer incidence in relation to vegetable and fruit consumption: a prospective study of atomic-bomb survivors. Int J Cancer 4-1-2000;86:132-138. View abstract.
  387. Dulloo, A. G., Seydoux, J., Girardier, L., Chantre, P., and Vandermander, J. Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes.Relat Metab Disord. 2000;24:252-258. View abstract.
  388. Key, T. J., Sharp, G. B., Appleby, P. N., Beral, V., Goodman, M. T., Soda, M., and Mabuchi, K. Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan. Br J Cancer 1999;81:1248-1256. View abstract.
  389. Benzie, I. F., Szeto, Y. T., Strain, J. J., and Tomlinson, B. Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr.Cancer 1999;34:83-87. View abstract.
  390. Freese, R., Basu, S., Hietanen, E., Nair, J., Nakachi, K., Bartsch, H., and Mutanen, M. Green tea extract decreases plasma malondialdehyde concentration but does not affect other indicators of oxidative stress, nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy females. Eur.J Nutr. 1999;38:149-157. View abstract.
  391. Alic, M. Green tea for remission maintenance in Crohn's disease? Am J Gastroenterol. 1999;94:1710-1711. View abstract.
  392. Tsuchiya, H. Effects of green tea catechins on membrane fluidity. Pharmacology 1999;59:34-44. View abstract.
  393. Katiyar, S. K., Matsui, M. S., Elmets, C. A., and Mukhtar, H. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin. Photochem.Photobiol. 1999;69:148-153. View abstract.
  394. Over, K. F., Hettiarachchy, N. S., Perumalla, A. V., Johnson, M. G., Meullenet, J. F., Dickson, J. S., Holtzbauer, M. J., Niebuhr, S. E., and Davis, B. Antilisterial activity and consumer acceptance of irradiated chicken breast meat vacuum-infused with grape seed and green tea extracts and tartaric acid. J Food Sci. 2010;75:M455-M461. View abstract.
  395. Kidd, P. M. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern.Med.Rev. 2009;14:226-246. View abstract.
  396. Henrotin, Y., Lambert, C., Couchourel, D., Ripoll, C., and Chiotelli, E. Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products. Osteoarthritis.Cartilage. 2011;19:1-21. View abstract.
  397. Hasani-Ranjbar, S., Nayebi, N., Moradi, L., Mehri, A., Larijani, B., and Abdollahi, M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review. Curr.Pharm.Des 2010;16:2935-2947. View abstract.
  398. Dulloo, A. G. and Miller, D. S. The thermogenic properties of ephedrine/methylxanthine mixtures: animal studies. Am J Clin Nutr 1986;43:388-394. View abstract.
  399. Huang, J., Frohlich, J., and Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. Can J Cardiol 2011;27:488-505. View abstract.
  400. Hooper, L., Kroon, P. A., Rimm, E. B., Cohn, J. S., Harvey, I., Le Cornu, K. A., Ryder, J. J., Hall, W. L., and Cassidy, A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008;88:38-50. View abstract.
  401. Westphal, L. M., Polan, M. L., and Trant, A. S. Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women. Clin Exp.Obstet.Gynecol. 2006;33:205-208. View abstract.
  402. Tjeerdsma, F., Jonkman, M. F., and Spoo, J. R. Temporary arrest of basal cell carcinoma formation in a patient with basal cell naevus syndrome (BCNS) since treatment with a gel containing various plant extracts. J.Eur.Acad.Dermatol.Venereol. 2011;25:244-245. View abstract.
  403. Lancaster, T., Muir, J., and Silagy, C. The effects of coffee on serum lipids and blood pressure in a UK population. J R.Soc Med 1994;87:506-507. View abstract.
  404. Somani, S. M. and Gupta, P. Caffeine: a new look at an age-old drug. Int.J.Clin.Pharmacol.Ther.Toxicol. 1988;26:521-533. View abstract.
  405. Smith, A. E., Lockwood, C. M., Moon, J. R., Kendall, K. L., Fukuda, D. H., Tobkin, S. E., Cramer, J. T., and Stout, J. R. Physiological effects of caffeine, epigallocatechin-3-gallate, and exercise in overweight and obese women. Appl Physiol Nutr Metab 2010;35:607-616. View abstract.
  406. Dalbo, V. J., Roberts, M. D., Stout, J. R., and Kerksick, C. M. Effect of gender on the metabolic impact of a commercially available thermogenic drink. J Strength.Cond.Res 2010;24:1633-1642. View abstract.
  407. Hursel, R. and Westerterp-Plantenga, M. S. Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss. Am J Clin Nutr 2009;89:822-830. View abstract.
  408. Maki, K. C., Reeves, M. S., Farmer, M., Yasunaga, K., Matsuo, N., Katsuragi, Y., Komikado, M., Tokimitsu, I., Wilder, D., Jones, F., Blumberg, J. B., and Cartwright, Y. Green tea catechin consumption enhances exercise-induced abdominal fat loss in overweight and obese adults. J Nutr 2009;139:264-270. View abstract.
  409. Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A. M., Spencer, J. P., Minihane, A. M., and Rimbach, G. Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men. J Nutr 2009;139:58-62. View abstract.
  410. Nagao, T., Meguro, S., Hase, T., Otsuka, K., Komikado, M., Tokimitsu, I., Yamamoto, T., and Yamamoto, K. A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Obesity.(Silver.Spring) 2009;17:310-317. View abstract.
  411. Hsu, C. H., Tsai, T. H., Kao, Y. H., Hwang, K. C., Tseng, T. Y., and Chou, P. Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr 2008;27:363-370. View abstract.
  412. Matsuyama, T., Tanaka, Y., Kamimaki, I., Nagao, T., and Tokimitsu, I. Catechin safely improved higher levels of fatness, blood pressure, and cholesterol in children. Obesity.(Silver.Spring) 2008;16:1338-1348. View abstract.
  413. Childs, E. and de, Wit H. Enhanced mood and psychomotor performance by a caffeine-containing energy capsule in fatigued individuals. Exp.Clin Psychopharmacol. 2008;16:13-21. View abstract.
  414. Belza, A., Toubro, S., and Astrup, A. The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake. Eur.J Clin Nutr 2009;63:57-64. View abstract.
  415. Nagao, T., Hase, T., and Tokimitsu, I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity.(Silver.Spring) 2007;15:1473-1483. View abstract.
  416. Fukino, Y., Ikeda, A., Maruyama, K., Aoki, N., Okubo, T., and Iso, H. Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur.J Clin Nutr 2008;62:953-960. View abstract.
  417. Fukino, Y., Shimbo, M., Aoki, N., Okubo, T., and Iso, H. Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol.(Tokyo) 2005;51:335-342. View abstract.
  418. Chan, C. C., Koo, M. W., Ng, E. H., Tang, O. S., Yeung, W. S., and Ho, P. C. Effects of Chinese green tea on weight, and hormonal and biochemical profiles in obese patients with polycystic ovary syndrome--a randomized placebo-controlled trial. J Soc Gynecol.Investig. 2006;13:63-68. View abstract.
  419. Diepvens, K., Kovacs, E. M., Vogels, N., and Westerterp-Plantenga, M. S. Metabolic effects of green tea and of phases of weight loss. Physiol Behav 1-30-2006;87:185-191. View abstract.
  420. Nagao, T., Komine, Y., Soga, S., Meguro, S., Hase, T., Tanaka, Y., and Tokimitsu, I. Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men. Am J Clin Nutr 2005;81:122-129. View abstract.
  421. Van Het Hof, K. H., Kivits, G. A., Weststrate, J. A., and Tijburg, L. B. Bioavailability of catechins from tea: the effect of milk. Eur.J Clin.Nutr. 1998;52:356-359. View abstract.
  422. Princen, H. M., van, Duyvenvoorde W., Buytenhek, R., Blonk, C., Tijburg, L. B., Langius, J. A., Meinders, A. E., and Pijl, H. No effect of consumption of green and black tea on plasma lipid and antioxidant levels and on LDL oxidation in smokers. Arterioscler.Thromb.Vasc.Biol. 1998;18:833-841. View abstract.
  423. Morse, M. A., Kresty, L. A., Steele, V. E., Kelloff, G. J., Boone, C. W., Balentine, D. A., Harbowy, M. E., and Stoner, G. D. Effects of theaflavins on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis. Nutr.Cancer 1997;29:7-12. View abstract.
  424. Van Het Hof, K. H., de Boer, H. S., Wiseman, S. A., Lien, N., Westrate, J. A., and Tijburg, L. B. Consumption of green or black tea does not increase resistance of low-density lipoprotein to oxidation in humans. Am.J Clin.Nutr. 1997;66:1125-1132. View abstract.
  425. Ishikawa, T., Suzukawa, M., Ito, T., Yoshida, H., Ayaori, M., Nishiwaki, M., Yonemura, A., Hara, Y., and Nakamura, H. Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification. Am.J Clin.Nutr. 1997;66:261-266. View abstract.
  426. Yam, T. S., Shah, S., and Hamilton-Miller, J. M. Microbiological activity of whole and fractionated crude extracts of tea (Camellia sinensis), and of tea components. FEMS Microbiol.Lett. 7-1-1997;152:169-174. View abstract.
  427. Brem, A. S., Martin, H., and Stern, L. Toxicity from tea ingestion in an infant: a computer simulation analysis. Clin Biochem. 1977;10:148-150. View abstract.
  428. Serafini, M., Ghiselli, A., and Ferro-Luzzi, A. In vivo antioxidant effect of green and black tea in man. Eur.J Clin Nutr. 1996;50:28-32. View abstract.
  429. Nakayama, M., Suzuki, K., Toda, M., Okubo, S., Hara, Y., and Shimamura, T. Inhibition of the infectivity of influenza virus by tea polyphenols. Antiviral Res. 1993;21:289-299. View abstract.
  430. Gao, Y. T., McLaughlin, J. K., Blot, W. J., Ji, B. T., Dai, Q., and Fraumeni, J. F., Jr. Reduced risk of esophageal cancer associated with green tea consumption. J Natl.Cancer Inst. 6-1-1994;86:855-858. View abstract.
  431. He, Y. H. and Kies, C. Green and black tea consumption by humans: impact on polyphenol concentrations in feces, blood and urine. Plant Foods Hum.Nutr. 1994;46:221-229. View abstract.
  432. Sano, M., Takahashi, Y., Yoshino, K., Shimoi, K., Nakamura, Y., Tomita, I., Oguni, I., and Konomoto, H. Effect of tea (Camellia sinensis L.) on lipid peroxidation in rat liver and kidney: a comparison of green and black tea feeding. Biol.Pharm Bull. 1995;18:1006-1008. View abstract.
  433. Rosen, S., Elvin-Lewis, M., Beck, F. M., and Beck, E. X. Anticariogenic effects of tea in rats. J Dent.Res. 1984;63:658-660. View abstract.
  434. Hattori, M., Kusumoto, I. T., Namba, T., Ishigami, T., and Hara, Y. Effect of tea polyphenols on glucan synthesis by glucosyltransferase from Streptococcus mutans. Chem.Pharm Bull.(Tokyo) 1990;38:717-720. View abstract.
  435. Stockfleth, E., Beti, H., Orasan, R., Grigorian, F., Mescheder, A., Tawfik, H., and Thielert, C. Topical Polyphenon E in the treatment of external genital and perianal warts: a randomized controlled trial. Br.J Dermatol. 2008;158:1329-1338. View abstract.
  436. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77:113-122. View abstract.
  437. Gross, G., Meyer, K. G., Pres, H., Thielert, C., Tawfik, H., and Mescheder, A. A randomized, double-blind, four-arm parallel-group, placebo-controlled Phase II/III study to investigate the clinical efficacy of two galenic formulations of Polyphenon E in the treatment of external genital warts. J Eur.Acad.Dermatol.Venereol. 2007;21:1404-1412. View abstract.
  438. Rogers, P. J., Smith, J. E., Heatherley, S. V., and Pleydell-Pearce, C. W. Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology (Berl) 2008;195:569-577. View abstract.
  439. Kohler, M., Pavy, A., and van den Heuvel, C. The effects of chewing versus caffeine on alertness, cognitive performance and cardiac autonomic activity during sleep deprivation. J Sleep Res. 2006;15:358-368. View abstract.
  440. Dagan, Y. and Doljansky, J. T. Cognitive performance during sustained wakefulness: A low dose of caffeine is equally effective as modafinil in alleviating the nocturnal decline. Chronobiol.Int. 2006;23:973-983. View abstract.
  441. Van Dorsten, F. A., Daykin, C. A., Mulder, T. P., and Van Duynhoven, J. P. Metabonomics approach to determine metabolic differences between green tea and black tea consumption. J Agric Food Chem 9-6-2006;54:6929-6938. View abstract.
  442. Henning, S. M., Aronson, W., Niu, Y., Conde, F., Lee, N. H., Seeram, N. P., Lee, R. P., Lu, J., Harris, D. M., Moro, A., Hong, J., Pak-Shan, L., Barnard, R. J., Ziaee, H. G., Csathy, G., Go, V. L., Wang, H., and Heber, D. Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J Nutr 2006;136:1839-1843. View abstract.
  443. Vlachopoulos, C., Alexopoulos, N., Dima, I., Aznaouridis, K., Andreadou, I., and Stefanadis, C. Acute effect of black and green tea on aortic stiffness and wave reflections. J Am Coll.Nutr 2006;25:216-223. View abstract.
  444. Mukoyama, A., Ushijima, H., Nishimura, S., Koike, H., Toda, M., Hara, Y., and Shimamura, T. Inhibition of rotavirus and enterovirus infections by tea extracts. Jpn.J Med.Sci Biol. 1991;44:181-186. View abstract.
  445. Sun, C. L., Yuan, J. M., Koh, W. P., and Yu, M. C. Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies. Carcinogenesis 2006;27:1301-1309. View abstract.
  446. Suzuki, J., Ogawa, M., Izawa, A., Sagesaka, Y. M., and Isobe, M. Dietary consumption of green tea catechins attenuate hyperlipidaemia-induced atherosclerosis and systemic organ damage in mice. Acta Cardiol. 2005;60:271-276. View abstract.
  447. Mulder, T. P., Rietveld, A. G., and Van Amelsvoort, J. M. Consumption of both black tea and green tea results in an increase in the excretion of hippuric acid into urine. Am.J.Clin Nutr. 2005;81(1 Suppl):256S-260S. View abstract.
  448. Ullmann, U., Haller, J., Decourt, J. D., Girault, J., Spitzer, V., and Weber, P. Plasma-kinetic characteristics of purified and isolated green tea catechin epigallocatechin gallate (EGCG) after 10 days repeated dosing in healthy volunteers. Int J Vitam.Nutr.Res. 2004;74:269-278. View abstract.
  449. Li, R., Huang, Y. G., Fang, D., and Le, W. D. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci.Res. 12-1-2004;78:723-731. View abstract.
  450. Ahmed, S., Wang, N., Lalonde, M., Goldberg, V. M., and Haqqi, T. M. Green tea polyphenol epigallocatechin-3-gallate (EGCG) differentially inhibits interleukin-1 beta-induced expression of matrix metalloproteinase-1 and -13 in human chondrocytes. J Pharmacol.Exp.Ther. 2004;308:767-773. View abstract.
  451. Chow, H. H., Cai, Y., Hakim, I. A., Crowell, J. A., Shahi, F., Brooks, C. A., Dorr, R. T., Hara, Y., and Alberts, D. S. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin Cancer Res. 8-15-2003;9:3312-3319. View abstract.
  452. Levites, Y., Amit, T., Mandel, S., and Youdim, M. B. Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J 2003;17:952-954. View abstract.
  453. Singh, R., Ahmed, S., Malemud, C. J., Goldberg, V. M., and Haqqi, T. M. Epigallocatechin-3-gallate selectively inhibits interleukin-1beta-induced activation of mitogen activated protein kinase subgroup c-Jun N-terminal kinase in human osteoarthritis chondrocytes. J Orthop.Res. 2003;21:102-109. View abstract.
  454. Choi, J. Y., Park, C. S., Kim, D. J., Cho, M. H., Jin, B. K., Pie, J. E., and Chung, W. G. Prevention of nitric oxide-mediated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease in mice by tea phenolic epigallocatechin 3-gallate. Neurotoxicology 2002;23:367-374. View abstract.
  455. Singh, R., Ahmed, S., Islam, N., Goldberg, V. M., and Haqqi, T. M. Epigallocatechin-3-gallate inhibits interleukin-1beta-induced expression of nitric oxide synthase and production of nitric oxide in human chondrocytes: suppression of nuclear factor kappaB activation by degradation of the inhibitor of nuclear factor kappaB. Arthritis Rheum. 2002;46:2079-2086. View abstract.
  456. Nie, G., Cao, Y., and Zhao, B. Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells. Redox.Rep. 2002;7:171-177. View abstract.
  457. Favreau, J. T., Ryu, M. L., Braunstein, G., Orshansky, G., Park, S. S., Coody, G. L., Love, L. A., and Fong, T. L. Severe hepatotoxicity associated with the dietary supplement LipoKinetix. Ann.Intern.Med. 4-16-2002;136:590-595. View abstract.
  458. Adcocks, C., Collin, P., and Buttle, D. J. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J Nutr. 2002;132:341-346. View abstract.
  459. Disler, P. B., Lynch, S. R., Charlton, R. W., Torrance, J. D., Bothwell, T. H., Walker, R. B., and Mayet, F. The effect of tea on iron absorption. Gut 1975;16:193-200. View abstract.
  460. Arts, I. C., Hollman, P. C., Feskens, E. J., Bueno de Mesquita, H. B., and Kromhout, D. Catechin intake might explain the inverse relation between tea consumption and ischemic heart disease: the Zutphen Elderly Study. Am.J.Clin Nutr. 2001;74:227-232. View abstract.
  461. McKenna, D. J., Hughes, K., and Jones, K. Green tea monograph. Altern.Ther Health Med. 2000;6:61-2, 74. View abstract.
  462. Gomes, A., Das, M., Vedasiromoni, J. R., and Ganguly, D. K. Proconvulsive effect of tea (Camellia sinensis) in mice. Phytother.Res. 1999;13:376-379. View abstract.
  463. Van Het Hof, K. H., Wiseman, S. A., Yang, C. S., and Tijburg, L. B. Plasma and lipoprotein levels of tea catechins following repeated tea consumption. Proc.Soc.Exp.Biol.Med 1999;220:203-209. View abstract.
  464. Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2006;34:577-82. View abstract.
  465. Hwang, J. T., Kwon, D. Y., and Yoon, S. H. AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N.Biotechnol. 10-1-2009;26(1-2):17-22. View abstract.
  466. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern.Ther.Health Med. 2010;16:32-40. View abstract.
  467. Williamson, G., Coppens, P., Serra-Majem, L., and Dew, T. Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials. Food Funct. 2011;2:753-759. View abstract.
  468. Kynast-Gales SA, Massey LK. Effect of caffeine on circadian excretion of urinary calcium and magnesium. J Am Coll Nutr. 1994;13:467-72. View abstract.
  469. Matsuo, C., Harashima, N., Sekine, K., Kanou, M., Kanazawa, M., Ishikawa, K., Nara, Y., and Ikeda, H. [Influence of commercial soft drinks or green tea intake to occult blood and sugar tests with urinalysis reagent strips]. Rinsho Byori 2009;57:834-841. View abstract.
  470. Seifert, J. G., Nelson, A., Devonish, J., Burke, E. R., and Stohs, S. J. Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. Int.J.Med.Sci. 2011;8:192-197. View abstract.
  471. Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. Drug Metab Pharmacokinet. 2004;19:280-289. View abstract.
  472. Chan, H. T., So, L. T., Li, S. W., Siu, C. W., Lau, C. P., and Tse, H. F. Effect of herbal consumption on time in therapeutic range of warfarin therapy in patients with atrial fibrillation. J.Cardiovasc.Pharmacol. 2011;58:87-90. View abstract.
  473. Smits, P., Temme, L., and Thien, T. The cardiovascular interaction between caffeine and nicotine in humans. Clin.Pharmacol.Ther. 1993;54:194-204. View abstract.
  474. Kato Y, Miyazaki T, Kano T, et al. Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol. J Pharm Sci 2009;98:2529-39. View abstract.
  475. Roth M, Timmermann BN, Hagenbuch B. Interactions of green tea catechins with organic anion-transporting polypeptides. Drug Metab Dispos 2011;39:920-6. View abstract.
  476. Misaka S, Yatabe J, Muller F, et al. Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects. Clin Pharmacol Ther 2014. [Epub ahead of print]. View abstract.
  477. Golden ED, Lam PY, Kardosh A, et al. Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood 2009;113:5927-37. View abstract.
  478. Phung OJ, Baker WL, Matthews LJ, et al. Effect of green tea catechins with or without caffeine on anthropometric measures: a systemic review and meta-analysis. Am J Clin Nutr 2010;91:73-81. View abstract.
  479. Bobe G, Weinstein SJ, Albanes D, et al. Flavonoid intake and risk of pancreatic cancer in male smokers (Finland). Cancer Epidemiol Biomarkers Prev 2008;17:553-62. View abstract.
  480. Savitz DA, Chan RL, Herring AH, et al. Caffeine and miscarriage risk. Epidemiology 2008;19:55-62. View abstract.
  481. Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 2008;198:279.e1-8. View abstract.
  482. Kundu T, Dey S, Roy M, et al. Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. Cancer Lett 2005;230:111-21. View abstract.
  483. Liu S, Lu H, Zhao Q, et al. Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41. Biochim Biophys Acta 2005;1723:270-81. View abstract.
  484. Yanagida A, Shoji A, Shibusawa Y, et al. Analytical separation of tea catechins and food-related polyphenols by high-speed counter-current chromatography. J Chromatogr A 2006;1112:195-201. View abstract.
  485. Taubert D, Roesen R, Schomig E. Effect of cocoa and tea intake on blood pressure: a meta-analysis. Arch Intern Med 2007;167:626-34. View abstract.
  486. Lorenz M, Jochmann N, von Krosigk A, et al. Addition of milk prevents vascular protective effects of tea. Eur Heart J 2007;28:219-23. View abstract.
  487. Correa A, Stolley A, Liu Y. Prenatal tea consumption and risks of anencephaly and spina bifida. Ann Epidemiol 2000;10:476-7. View abstract.
  488. Bradley Pharmaceuticals. Veregen Prescribing Information. October 2006.
  489. Katiyar SK, Mohan RR, Agarwal R, Mukhtar H. Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis 1997;18:497-502. View abstract.
  490. Jimenez-Saenz M, Martinez-Sanchez, MDC. Acute hepatitis associated with the use of green tea infusions. J Hepatol 2006;44:616-9. View abstract.
  491. Navarro-Peran E, Cabezas-Herrera J, Garcia-Canovas F, et al. The antifolate activity of tea catechins. Cancer Res 2005;65:2059-64. View abstract.
  492. Isbrucker RA, Edwards JA, Wolz E, et al. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in rats. Food Chem Toxicol 2006;44:651-61. View abstract.
  493. Chu KO, Wang CC, Chu CY, et al. Pharmacokinetic studies of green tea catechins in maternal plasma and fetuses in rats. J Pharm Sci 2006;95:1372-81. View abstract.
  494. Kuriyama S, Shimazu T, Ohmori K, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all-cause mortality. JAMA 2006;296:1255-65. View abstract.
  495. Wu AH, Tseng CC, Van Den Berg D, Yu MC. Tea intake, COMT genotype, and breast cancer in Asian-American women. Cancer Res 2003;63:7526-9. View abstract.
  496. Yuan JM, Koh WP, Sun CL, et al. Green tea intake, ACE gene polymorphism and breast cancer risk among Chinese women in Singapore. Carcinogenesis 2005;26:1389-94. View abstract.
  497. Donovan JL, Chavin KD, Devane CL, et al. Green tea (Camellia sinensis) extract does not alter cytochrome P450 3A4 or 2D6 activity in healthy volunteers. Drug Metab Dispos 2004;32:906-8. View abstract.
  498. Kovacs EM, Lejeune MP, Nijs I, Westerterp-Plantenga MS. Effects of green tea on weight maintenance after body-weight loss. Br J Nutr 2004;91:431-7. View abstract.
  499. Wu AH, Yu MC, Tseng CC, et al. Green tea and risk of breast cancer in Asian Americans. Int J Cancer 2003;106:574-9. View abstract.
  500. Suzuki Y, Tsubono Y, Nakaya N, et al. Green tea and the risk of breast cancer: pooled analysis of two prospective studies in Japan. Br J Cancer 2004;90:1361-3. View abstract.
  501. Iso H, Date C, Wakai K, et al; JACC Study Group. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 2006;144:554-62. View abstract.
  502. Gloro R, Hourmand-Ollivier I, Mosquet B, et al. Fulminant hepatitis during self-medication with hydroalcoholic extract of green tea. Eur J Gastroenterol Hepatol 2005;17:1135-7. View abstract.
  503. Bonkovsky HL. Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). Ann Intern Med 2006;144:68-71. View abstract.
  504. Henning M, Fajardo-Lira C, Lee HW, et al. Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity. Nutr Cancer 2003;45:226-35. View abstract.
  505. Khokhar S, Magnusdottir SG. Total phenol, catechin, and caffeine contents of teas commonly consumed in the United kingdom. J Agric Food Chem 2002;50:565-70. View abstract.
  506. Jian L, Xie LP, Lee AH, Binns CW. Protective effect of green tea against prostate cancer: a case-control study in southeast China. Int J Cancer 2004;108:130-5. View abstract.
  507. Bettuzzi S, Brausi M, Rizzi F, et al. Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res 2006;66:1234-40. View abstract.
  508. Robinson LE, Savani S, Battram DS, et al. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J Nutr 2004;134:2528-33. View abstract.
  509. Lake CR, Rosenberg DB, Gallant S, et al. Phenylpropanolamine increases plasma caffeine levels. Clin Pharmacol Ther 1990;47:675-85. View abstract.
  510. Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41. View abstract.
  511. Raaska K, Raitasuo V, Laitila J, Neuvonen PJ. Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Basic Clin Pharmacol Toxicol 2004;94:13-8. View abstract.
  512. Watson JM, Sherwin RS, Deary IJ, et al. Dissociation of augmented physiological, hormonal and cognitive responses to hypoglycaemia with sustained caffeine use. Clin Sci (Lond) 2003;104:447-54. View abstract.
  513. Winkelmayer WC, Stampfer MJ, Willett WC, Curhan GC. Habitual caffeine intake and the risk of hypertension in women. JAMA 2005;294:2330-5. View abstract.
  514. Juliano LM, Griffiths RR. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology (Berl) 2004;176:1-29. View abstract.
  515. Leson CL, McGuigan MA, Bryson SM. Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol 1988;26:407-15. View abstract.
  516. Benowitz NL, Osterloh J, Goldschlager N, et al. Massive catecholamine release from caffeine poisoning. JAMA 1982;248:1097-8. View abstract.
  517. Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr 2004;79:40-6. View abstract.
  518. Scholey AB, Kennedy DO. Cognitive and physiological effects of an "energy drink:" an evaluation of the whole drink and of glucose, caffeine and herbal flavouring fractions. Psychopharmacology (Berl) 2004;176:320-30. View abstract.
  519. Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003.. View abstract.
  520. Larsson SC, Wolk A. Tea consumption and ovarian cancer risk in a population-based cohort. Arch Intern Med 2005;165:2683-6. View abstract.
  521. Schabath MB, Hernandez LM, Wu X, et al. Dietary phytoestrogens and lung cancer risk. JAMA 2005;294:1493-1504. View abstract.
  522. Seely D, Mills EJ, Wu P, et al. The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review and meta-analysis. Integr Cancer Ther 2005;4:144-55. View abstract.
  523. Sonoda T, Nagata Y, Mori M, et al. A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet. Cancer Sci 2004;95:238-42. . View abstract.
  524. Son DJ, Cho MR, Jin YR, et al. Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway. Prostaglandins Leukot Essent Fatty Acids 2004;71:25-31. View abstract.
  525. Choi JH, Chai YM, Joo GJ, et al. Effects of green tea catechin on polymorphonuclear leukocyte 5'-lipoxygenase activity, leukotriene B4 synthesis, and renal damage in diabetic rats. Ann Nutr Metab 2004;48:151-5. View abstract.
  526. Mohseni H, Zaslau S, McFadden D, et al. COX-2 inhibition demonstrates potent anti-proliferative effects on bladder cancer in vitro. J Surg Res 2004;119:138-42 . View abstract.
  527. Gupta S, Saha B, Giri AK. Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review. Mutat Res 2002;512:37-65. View abstract.
  528. Yang YC, Lu FH, Wu JS, et al. The protective effect of habitual tea consumption on hypertension. Arch Intern Med 2004 26;164:1534-40. View abstract.
  529. Haqqi TM, Anthony DD, Gupta S, et al. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc Natl Acad Sci U S A 1999;96:4524-9. View abstract.
  530. Adcocks C, Collin P, Buttle DJ. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J Nutr 2002;132:341-6. View abstract.
  531. Ahmed S, Rahman A, Hasnain A, et al. Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1 beta-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes. Free Radic Biol Med 2002;33:1097-105. View abstract.
  532. Petrie HJ, Chown SE, Belfie LM, et al. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am J Clin Nutr 2004;80:22-8. View abstract.
  533. Lane JD, Barkauskas CE, Surwit RS, Feinglos MN. Caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 2004;27:2047-8. View abstract.
  534. Lu K, Gray MA, Oliver C, et al. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans. Hum Psychopharmacol 2004;19:457-65. View abstract.
  535. Vinson JA, Teufel K, Wu N. Green and black teas inhibit atherosclerosis by lipid, antioxidant, and fibrinolytic mechanisms. J Agric Food Chem 2004;52:3661-5. View abstract.
  536. Zheng G, Sayama K, Okubo T, et al. Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice. In Vivo 2004;18:55-62. View abstract.
  537. Sato J, Nakata H, Owada E, et al. Influence of usual intake of dietary caffeine on single-dose kinetics of theophylline in healthy human subjects. Eur J Clin Pharmacol 1993;44:295-8. View abstract.
  538. Cannon ME, Cooke CT, McCarthy JS. Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. Med J Aust 2001;174:520-1. View abstract.
  539. Durrant KL. Known and hidden sources of caffeine in drug, food, and natural products. J Am Pharm Assoc 2002;42:625-37. View abstract.
  540. Beach CA, Mays DC, Guiler RC, et al. Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics. Clin Pharmacol Ther 1986;39:265-70. View abstract.
  541. Dews PB, O'Brien CP, Bergman J. Caffeine: behavioral effects of withdrawal and related issues. Food Chem Toxicol 2002;40:1257-61. View abstract.
  542. Holmgren P, Norden-Pettersson L, Ahlner J. Caffeine fatalities--four case reports. Forensic Sci Int 2004;139:71-3. View abstract.
  543. Chou T. Wake up and smell the coffee. Caffeine, coffee, and the medical consequences. West J Med 1992;157:544-53. View abstract.
  544. Howell LL, Coffin VL, Spealman RD. Behavioral and physiological effects of xanthines in nonhuman primates. Psychopharmacology (Berl) 1997;129:1-14. View abstract.
  545. Rakic V, Beilin LJ, Burke V. Effect of coffee and tea drinking on postprandial hypotension in older men and women. Clin Exp Pharmacol Physiol 1996;23:559-63. View abstract.
  546. Heseltine D, Dakkak M, woodhouse K, et al. The effect of caffeine on postprandial hypotension in the elderly. J Am Geriatr Soc 1991;39:160-4. View abstract.
  547. Castellanos FX, Rapoport JL. Effects of caffeine on development and behavior in infancy and childhood: a review of the published literature. Food Chem Toxicol 2002;40:1235-42. View abstract.
  548. Institute of Medicine. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. Washington, DC: National Academy Press, 2001. Available at:
  549. Zheng XM, Williams RC. Serum caffeine levels after 24-hour abstention: clinical implications on dipyridamole Tl myocardial perfusion imaging. J Nucl Med Technol 2002;30:123-7. View abstract.
  550. Aqel RA, Zoghbi GJ, Trimm JR, et al. Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease. Am J Cardiol 2004;93:343-6. View abstract.
  551. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. View abstract.
  552. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol 2002;40:1243-55. View abstract.
  553. Stanek EJ, Melko GP, Charland SL. Xanthine interference with dipyridamole-thallium-201 myocardial imaging. Pharmacother 1995;29:425-7. View abstract.
  554. Carrillo JA, Benitez J. Clinically significant pharmacokinetic interactions between dietary caffeine and medications. Clin Pharmacokinet 2000;39:127-53. View abstract.
  555. Wahllander A, Paumgartner G. Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers. Eur J Clin Pharmacol 1989;37:279-83. View abstract.
  556. Sanderink GJ, Bournique B, Stevens J, et al. Involvement of human CYP1A isoenzymes in the metabolism and drug interactions of riluzole in vitro. Pharmacol Exp Ther 1997;282:1465-72. View abstract.
  557. Brown NJ, Ryder D, Branch RA. A pharmacodynamic interaction between caffeine and phenylpropanolamine. Clin Pharmacol Ther 1991;50:363-71. View abstract.
  558. May DC, Jarboe CH, VanBakel AB, Williams WM. Effects of cimetidine on caffeine disposition in smokers and nonsmokers. Clin Pharmacol Ther 1982;31:656-61. View abstract.
  559. Nawrot P, Jordan S, Eastwood J, et al. Effects of caffeine on human health. Food Addit Contam 2003;20:1-30. View abstract.
  560. Jatoi A, Ellison N, Burch PA, et al. A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer 2003;97:1442-6.. View abstract.
  561. Shirai T, Hayakawa H, Akiyama J, et al. Food allergy to green tea. J Allergy Clin Immunol 2003;112:805-6. View abstract.
  562. Massey LK, Whiting SJ. Caffeine, urinary calcium, calcium metabolism and bone. J Nutr 1993;123:1611-4. View abstract.
  563. Infante S, Baeza ML, Calvo M, et al. Anaphylaxis due to caffeine. Allergy 2003;58:681-2. View abstract.
  564. Ahn WS, Yoo J, Huh SW, et al. Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions. Eur J Cancer Prev 2003;12:383-90. View abstract.
  565. Kemberling JK, Hampton JA, Keck RW, et al. Inhibition of bladder tumor growth by the green tea derivative epigallocatechin-3-gallate. J Urol 2003;170:773-6. View abstract.
  566. Maron DJ, Lu GP, Cai NS, et al. Cholesterol-lowering effect of a theaflavin-enriched green tea extract: a randomized controlled trial. Arch Intern Med 2003;163:1448-53.. View abstract.
  567. Nix D, Zelenitsky S, Symonds W, et al. The effect of fluconazole on the pharmacokinetics of caffeine in young and elderly subjects. Clin Pharmacol Ther 1992;51:183.
  568. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. View abstract.
  569. Grandjean AC, Reimers KJ, Bannick KE, Haven MC. The effect of caffeinated, non-caffeinated, caloric and non-caloric beverages on hydration. J Am Coll Nutr 2000;19:591-600.. View abstract.
  570. Dreher HM. The effect of caffeine reduction on sleep quality and well-being in persons with HIV. J Psychosom Res 2003;54:191-8.. View abstract.
  571. Massey LK. Is caffeine a risk factor for bone loss in the elderly? Am J Clin Nutr 2001;74:569-70. View abstract.
  572. Nehlig A, Debry G. Consequences on the newborn of chronic maternal consumption of coffee during gestation and lactation: a review. J Am Coll Nutr 1994;13:6-21.. View abstract.
  573. McGowan JD, Altman RE, Kanto WP Jr. Neonatal withdrawal symptoms after chronic maternal ingestion of caffeine. South Med J 1988;81:1092-4.. View abstract.
  574. Bara AI, Barley EA. Caffeine for asthma. Cochrane Database Syst Rev 2001;4:CD001112.. View abstract.
  575. Bracken MB, Triche EW, Belanger K, et al. Association of maternal caffeine consumption with decrements in fetal growth. Am J Epidemiol 2003;157:456-66.. View abstract.
  576. Temme EH, Van Hoydonck PG. Tea consumption and iron status. Eur J Clin Nutr 2002;56:379-86.. View abstract.
  577. Leung LK, Su Y, Chen R, et al. Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutr 2001;131:2248-51.. View abstract.
  578. de Maat MP, Pijl H, Kluft C, Princen HM. Consumption of black and green tea had no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals. Eur J Clin Nutr 2000;54:757-63.. View abstract.
  579. Hodgson JM, Croft KD, Mori TA, et al. Regular ingestion of tea does not inhibit in vivo lipid peroxidation in humans. J Nutr 2002;132:55-8.. View abstract.
  580. Locher R, Emmanuele L, Suter PM, et al. Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein. Eur J Pharmacol 2002;434:1-7.. View abstract.
  581. Zhang M, Binns CW, Lee AH. Tea consumption and ovarian cancer risk: a case-control study in China. Cancer Epidemiol Biomarkers Prev 2002;11:713-8.. View abstract.
  582. Yu GP, Hsieh CC. Risk factors for stomach cancer: a population-based case-control study in Shanghai. Cancer Causes Control 1991;2:169-74.. View abstract.
  583. Ji BT, Chow WH, Yang G, et al. The influence of cigarette smoking, alcohol, and green tea consumption on the risk of carcinoma of the cardia and distal stomach in Shanghai, China. Cancer 1996;77:2449-57.. View abstract.
  584. Kono S, Ikeda M, Tokudome S, Kuratsune M. A case-control study of gastric cancer and diet in northern Kyushu, Japan. Jpn J Cancer Res 1988;79:1067-74.. View abstract.
  585. Choi YT, Jung CH, Lee SR, et al. The green tea polyphenol (-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons. Life Sci 2001;70:603-14.. View abstract.
  586. Tajima K, Tominaga S. Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 1985;76:705-16.. View abstract.
  587. Inoue M, Tajima K, Hirose K, et al. Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan. Cancer Causes Control 1998;9:209-16.. View abstract.
  588. Horner NK, Lampe JW. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. J Am Diet Assoc 2000;100:1368-80. View abstract.
  589. Zijp IM, Korver O, Tijburg LB. Effect of tea and other dietary factors on iron absorption. Crit Rev Food Sci Nutr 2000;40:371-98. View abstract.
  590. Setiawan VW, Zhang ZF, Yu GP, et al. Protective effect of green tea on the risks of chronic gastritis and stomach cancer. Int J Cancer 2001;92:600-4. View abstract.
  591. Bell DG, Jacobs I, Ellerington K. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 2001;33:1399-403. View abstract.
  592. Haller CA, Jacob P 3rd, Benowitz NL. Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. Clin Pharmacol Ther 2002;71:421-32. View abstract.
  593. Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother 2002;36:992-5.. View abstract.
  594. Esimone CO, Adikwu MU, Nwafor SV, Okolo CO. Potential use of tea extract as a complementary mouthwash: comparative evaluation of two commercial samples. J Altern Complement Med 2001;7:523-7. View abstract.
  595. Peters U, Poole C, Arab L. Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol 2001;154:495-503. View abstract.
  596. Mukamal KJ, Maclure M, Muller JE, et al. Tea consumption and mortality after acute myocardial infarction. Circulation 2002;105:2476-81. View abstract.
  597. Geleijnse JM, Launer LJ, van der Kuip DA, et al. Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study. Am J Clin Nutr 2002;75:880-6. View abstract.
  598. Chung LY, Cheung TC, Kong SK, et al. Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. Life Sci 2001;68:1207-14. View abstract.
  599. Pisters KM, Newman RA, Coldman B, et al. Phase I trial of oral green tea extract in adult patients with solid tumors. J Clin Oncol 2001;19:1830-8. View abstract.
  600. Wu CH, Yang YC, Yao WJ, et al. Epidemiological evidence of increased bone mineral density in habitual tea drinkers. Arch Intern Med 2002;162:1001-6. View abstract.
  601. Cronin JR. Green tea extract stokes thermogenesis: will it replace ephedra? Altern Comp Ther 2000;6:296-300.
  602. Chantre P, Lairon D. Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 2002;9:3-8. View abstract.
  603. Shaw JC. Green tea polyphenols may be useful in the treatment of androgen-mediated skin disorders. Arch Dermatol 2001;137:664. View abstract.
  604. Samman S, Sandstrom B, Toft MB, et al. Green tea or rosemary extract added to foods reduces nonheme-iron absorption. Am J Clin Nutr 2001;73:607-12. View abstract.
  605. Ferrini RL, Barrett-Connor E. Caffeine intake and endogenous sex steroid levels in postmenopausal women. The Rancho Bernardo Study. Am J Epidemiol 1996:144:642-4. View abstract.
  606. Ardlie NG, Glew G, Schultz BG, Schwartz CJ. Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 1967;18:670-3. View abstract.
  607. Ali M, Afzal M. A potent inhibitor of thrombin stimulated platelet thromboxane formation from unprocessed tea. Prostaglandins Leukot Med 1987;27:9-13. View abstract.
  608. Sadzuka Y, Sugiyama T, Sonobe T. Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance. Toxicol Lett 2000;114:155-62. View abstract.
  609. Krahwinkel T, Willershausen B. The effect of sugar-free green tea chew candies on the degree of inflammation of the gingiva. Eur J Med Res 2000;5:463-7. View abstract.
  610. Tsubono Y, Nishino Y, Komatsu S, et al. Green tea and the risk of gastric cancer in Japan. N Engl J Med 2001;344:632-6. View abstract.
  611. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000;343:1833-8. View abstract.
  612. Imai K. Nakachi K. Cross-sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ 1995;310:693-6. View abstract.
  613. Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9. View abstract.
  614. Katiyar SK, Ahmad N, Mukhtar H. Green Tea and Skin. Arch Dermatol 2000;136:989-94. View abstract.
  615. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. View abstract.
  616. Hodgson JM, Puddey IB, Croft KD, et al. Acute effects of ingestion of black and green tea on lipoprotein oxidation. Am J Clin Nutr 2000;71:1103-7. View abstract.
  617. Leenen R, Roodenburg AJ, Tijburg LB, et al. A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 2000;54:87-92. View abstract.
  618. Nemecz G. Green tea. US Pharm 2000;May:67-70.
  619. American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. View abstract.
  620. Lloyd T, Johnson-Rollings N, Eggli DF, et al. Bone status among postmenopausal women with different habitual caffeine intakes: a longitudinal investigation. J Am Coll Nutr 2000;19:256-61. View abstract.
  621. Watson JM, Jenkins EJ, Hamilton P, et al. Influence of caffeine on the frequency and perception of hypoglycemia in free-living patients with type 1 diabetes. Diabetes Care 2000;23:455-9. View abstract.
  622. Ross GW, Abbott RD, Petrovitch H, et al. Association of coffee and caffeine intake with the risk of parkinson disease. JAMA 2000;283:2674-9. View abstract.
  623. Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition 2000;16:330-8. View abstract.
  624. Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. View abstract.
  625. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: 786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view= text&node=21:
  626. Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr 1998;17:216-34. View abstract.
  627. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  628. Hindmarch I, Quinlan PT, Moore KL, Parkin C. The effects of black tea and other beverages on aspects of cognition and psychomotor performance. Psychopharmacol 1998;139:230-8. View abstract.
  629. Durlach PJ. The effects of a low dose of caffeine on cognitive performance. Psychopharmacology (Berl) 1998;140:116-9. View abstract.
  630. Kaegi E. Unconventional therapies for cancer: 2. Green tea. The Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. CMAJ 1998;158:1033-5. View abstract.
  631. Lee IP, Kim YH, Kang MH, et al. Chemopreventive effect of green tea (Camellia sinensis) against cigarette smoke induced mutations in humans. J Cell Biochem Suppl 1997;27:68-75. View abstract.
  632. Li N, Sun Z, Han C, Chen J. The chemopreventive effects of tea on human oral precancerous mucosa lesions. Proc Soc Exp Biol Med 1999;220:218-24. View abstract.
  633. Klaunig JE, Xu Y, Han C, et al. The effect of tea consumption on oxidative stress in smokers and nonsmokers. Proc Soc Exp Biol Med 1999;220:249-54. View abstract.
  634. Taylor JR, Wilt VM. Probable antagonism of warfarin by green tea. Ann Pharmacother 1999;33:426-8. View abstract.
  635. Bak AA, Grobbee DE. The effect of serum cholesterol levels of coffee brewed by filtering or boiling. N Engl J Med 1989;321:1432-7. View abstract.
  636. Weisburger JH. Tea and health: the underlying mechanisms. Proc Soc Exp Biol Med 1999;220:271-5. View abstract.
  637. Stammler G, Volm M. Green tea catechins (EGCG and EGC) have modulating effects on the activity of doxorubicin in drug-resistant cell lines. Anticancer Drugs 1997;8:265-8. View abstract.
  638. Inoue M, Tajima K, Mizutani M, et al. Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. Cancer Lett 2001;167:175-82. View abstract.
  639. Kao YH, Hiipakka RA, Liao S. Modulation of endocrine systems and food intake by green tea epigallocatechin gallate. Endocrinology 2000;141:980-7. View abstract.
  640. FDA. Proposed rule: dietary supplements containing ephedrine alkaloids. Available at: (Accessed 25 January 2000).
  641. Dews PB, Curtis GL, Hanford KJ, O'Brien CP. The frequency of caffeine withdrawal in a population-based survey and in a controlled, blinded pilot experiment. J Clin Pharmacol 1999;39:1221-32. View abstract.
  642. Nurminen ML, Niittynen L, Korpela R, Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur J Clin Nutr 1999;53:831-9. View abstract.
  643. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  644. Migliardi JR, Armellino JJ, Friedman M, et al. Caffeine as an analgesic adjuvant in tension headache. Clin Pharmacol Ther 1994;56:576-86. View abstract.
  645. Pollock BG, Wylie M, Stack JA, et al. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999;39:936-40. View abstract.
  646. Wemple RD, Lamb DR, McKeever KH. Caffeine vs caffeine-free sports drinks: effects on urine production at rest and during prolonged exercise. Int J Sports Med 1997;18:40-6. View abstract.
  647. Stookey JD. The diuretic effects of alcohol and caffeine and total water intake misclassification. Eur J Epidemiol 1999;15:181-8. View abstract.
  648. Fernandes O, Sabharwal M, Smiley T, et al. Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol 1998;12:435-44. View abstract.
  649. Eskenazi B. Caffeine—filtering the facts. N Engl J Med 1999;341:1688-9. View abstract.
  650. Klebanoff MA, Levine RJ, DerSimonian R, et al. Maternal serum paraxanthine, a caffeine metabolite, and the risk of spontaneous abortion. N Engl J Med 1999;341:1639-44. View abstract.
  651. The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at:
  652. Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL. Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes. Am J Clin Nutr 2001;74:694-700. View abstract.
  653. Chiu KM. Efficacy of calcium supplements on bone mass in postmenopausal women. J Gerontol A Biol Sci Med Sci 1999;54:M275-80. View abstract.
  654. Vandeberghe K, Gillis N, Van Leemputte M, et al. Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 1996;80:452-7. View abstract.
  655. Asmawi MZ, Kankaanranta H, Moilanen E, Vapaatalo H. Anti-inflammatory activities of Emblica officinalis Gaertn leaf extracts. J Pharm Pharmacol 1993;45:581-4. View abstract.
  656. Wallach J. Interpretation of Diagnostic Tests. A synopsis of Laboratory Medicine. Fifth ed; Boston, MA: Little Brown, 1992.
  657. Graham HN. Green tea composition, consumption, and polyphenol chemistry. Prev Med 1992;21:334-50. View abstract.
  658. Lou FQ, Zhang MF, Zhang XG, et al. A study on tea-pigment in prevention of atherosclerosis. Chin Med J (Engl) 1989;102:579-83. View abstract.
  659. Booth SL, Madabushi HT, Davidson KW, et al. Tea and coffee brews are not dietary sources of vitamin K-1 (phylloquinone). J Am Diet Assoc 1995;95:82-3. View abstract.
  660. Ohno Y, Aoki K, Obata K, et al. Case-control study of urinary bladder cancer in metropolitan Nagoya. Natl Cancer Inst Monogr 1985;69:229-34. View abstract.
  661. Wakai K, Ohno Y, Obata K. Prognostic significance of selected lifestyle factors in urinary bladder cancer. Jpn J Cancer Res 1993;84:1223-9. View abstract.
  662. Bushman JL. Green tea and cancer in humans: a review of the literature. Nutr Cancer 1998;31:151-9. View abstract.
  663. L'Allemain G. [Multiple actions of EGCG, the main component of green tea]. Bull Cancer 1999;86:721-4. View abstract.
  664. Cao Y, Cao R. Angiogenesis inhibited by drinking tea. Nature 1999;398:381. View abstract.
  665. Garbisa S, Biggin S, Cavallarin N, et al. Tumor invasion: molecular shears blunted by green tea. Nat Med 1999;5:1216. View abstract.
  666. Dulloo AG, Duret C, Rohrer D, et al. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999;70:1040-5. View abstract.
  667. Hodgson JM, Puddey IB, Burke V, et al. Effects on blood pressure of drinking green and black tea. J Hypertens 1999;17:457-63. View abstract.
  668. Wakabayashi K, Kono S, Shinchi K, et al. Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan. Eur J Epidemiol 1998;14:669-73. View abstract.
  669. Elmets CA, Singh D, Tubesing K, et al. Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J Am Acad Dermatol 2001;44:425-32. View abstract.
  670. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3. View abstract.
  671. Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. View abstract.
  672. Ascherio A, Zhang SM, Hernan MA, et al. Prospective study of caffeine intake and risk of Parkinson's disease in men and women. Proceedings 125th Ann Mtg Am Neurological Assn. Boston, MA: 2000;Oct 15-18:42 (abstract 53).
  673. Mitscher LA, Mitscher LA, Jung M, Shankel D, et al. Chemoprotection: a review of the potential therapeutic antioxidant properties of green tea (Camellia sinensis) and certain of its constituents. Med Res Rev 1997;17:327-65. View abstract.
  674. Merhav H, Amitai Y, Palti H, Godfrey S. Tea drinking and microcytic anemia in infants. Am J Clin Nutr 1985;41:1210-3. View abstract.
  675. Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3. View abstract.
  676. Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. View abstract.
  677. Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. View abstract.
  678. Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. View abstract.
  679. Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. View abstract.
  680. Foster S, Duke JA. Eastern/Central Medicinal Plants. New York, NY: Houghton Mifflin Co., 1990.
  681. Cone EH, Lange R, Darwin WD. In vivo adulteration: excess fluid ingestion causes false-negative marijuana and cocaine urine test results. J Anal Toxicol 1998;22:460-73. View abstract.
  682. Hertog MGL, Sweetnam PM, Fehily AM, et al. Antioxidant flavonols and ischemic heart disease in a Welsh population of men: the Caerphilly Study. Am J Clin Nutr 1997;65:1489-94. View abstract.
  683. Kubota K, Sakurai T, Nakazato K, et al. [Effect of green tea on iron absorption in elderly patients with iron deficiency anemia]. Nippon Ronen Igakkai Zasshi 1990;27:555-8. View abstract.
  684. Caraballo PJ, Heit JA, Atkinson EJ, et al. Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 1999;159:1750-6. View abstract.
  685. McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  686. United States Pharmacopeial Convention, Inc., ed. Drug Information for the Health Care Professional. 19th ed. Englewood, CO: Micromedex Inc., 1999.
  687. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  688. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
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