Other forms of Cushing syndrome include:
Cushing syndrome is a disorder that occurs when your body has a higher than normal level of the hormone cortisol. This hormone is made in the adrenal glands. Too much cortisol can be due to various problems. One such problem is a tumor on one of the adrenal glands. Adrenal tumors release cortisol.
Adrenal tumors are rare. They can be noncancerous (benign) or cancerous (malignant).
Noncancerous tumors that can cause Cushing syndrome include:
Cancerous tumors that may cause Cushing syndrome include an adrenal carcinoma.
Most people with Cushing syndrome have:
Skin changes that are often seen:
Muscle and bone changes include:
Women often have:
Men may have:
Other symptoms that may occur include:
The health care provider will perform a physical exam and ask about your symptoms.
Tests to confirm Cushing syndrome:
Tests to determine cause or complications include:
Surgery is done to remove the adrenal tumor. Often, the entire adrenal gland is removed.
Glucocorticoid replacement treatment is usually needed until the other adrenal gland recovers from surgery. You may need this treatment for 9 to 12 months.
If surgery is not possible, such as in cases of adrenal cancer, medicines can be used to stop the release of cortisol.
Patients with an adrenal tumor who have surgery have an excellent outlook. For adrenal cancer, surgery is sometimes not possible. When surgery is performed, it does not always cure the cancer.
Cancerous adrenal tumors can spread to the liver or lungs.
Call your health care provider if you develop any symptoms of Cushing syndrome.
Appropriate treatment of adrenal tumors may reduce the risk of complications in some patients with tumor-related Cushing syndrome.
Adrenal tumor - Cushing syndrome
McGee S. Cushing syndrome. In: Evidence-Based Physical Diagnosis. 3rd ed. Philadelphia, Pa: Elsevier Saunders. 2012:chap 13.
Stewart PM, Krone NP. The adrenal cortex. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 15.
Susmeeta TS, Nieman LK. Cushing's syndrome: all variants, detection, and treatment. Endocrinol Metab Clin N Am. 2011;40:379–391.
Updated by: Brent Wisse, MD, Associate Professor of Medicine, Division of Metabolism, Endocrinology & Nutrition, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
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