Mucormycosis is a fungal infection of the sinuses, brain, or lungs that occurs in some people with a weakened immune system.
Mucormycosis is caused by a common fungus frequently found in the soil and in dying plants. Most people come in contact with the fungus at some time. However, people with a weakened immune system are more likely to get this infection.
Conditions most commonly associated with mucormycosis include:
Mucormycosis may involve:
Symptoms of rhinocerebral mucormycosis include:
Symptoms of lung (pulmonary) mucormycosis include:
Symptoms of gastrointestinal mucormycosis include:
Symptoms of kidney (renal) mucormycosis include:
Symptoms of skin (cutaneous) mucormycosis include a single, painful, hardened area of skin that may have a blackened center.
The doctor or nurse will examine you. An ear-nose-throat (ENT) doctor should be seen if you are having sinus problems.
Testing depends on your symptoms but may include:
A biopsy must be done to make a definitive diagnosis of mucormycosis.
Surgery should be done immediately to remove all dead and infected tissue. Surgery can lead to disfiguration because it may involve removal of the palate, parts of the nose, or parts of the eye. Without such aggressive surgery, however, chances of survival are greatly decreased.
You will also receive antifungal medicines through a vein, usually amphotericin B.
Mucormycosis has an extremely high death rate even when aggressive surgery is done. Death rates range from 25 - 85% depending on the body area involved and your overall health.
People with weakened immune systems and immune disorders (including diabetes) should seek medical attention if they develop fever, headache, sinus pain, eye swelling, or any of the other symptoms listed above.
Because the fungi that cause mucormycosis are widespread, the most appropriate preventive measures involve improved control of the underlying illnesses associated with mucormycosis.
Kontoyiannis DP. Mucormycosis. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 348.
Kontoyiannis DP, Lewis RE. Agents of mucormycosis and entomophthoramycosis.In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 259.
Updated by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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