Multiple lentigines syndrome is an inherited disorder identified by an increased number of lentigines (freckle-like spots).
Multiple lentigines syndrome is inherited as an autosomal dominant trait. People with this condition have large numbers of lentigines. Lentigines are skin markings that are somewhat darker than true freckles. They are present from birth. They are located mostly on the trunk and neck.
Symptoms of multiple lentigines include:
Note: Scattered lentigines is normal and does not indicate a problem.
The health care provider will perform a physical exam and listen to your heart with a stethoscope. There may be signs of a heart valve problems or obstructive cardiomyopathy.
Tests that may be done can include:
Symptoms are treated as appropriate. A hearing aid may be needed. Hormone treatment may be necessary at the expected time of puberty to cause the normal changes to occur.
Laser or bleaching creams may help lighten some of the brown spots on the skin.
Most patients adjust very well with proper attention to their specific problems.
Complications vary and include:
Call your health care provider if there are symptoms of this disorder.
Call for an appointment with your health care provider if you have a family history of this disorder and plan to have children.
Genetic counseling is recommended for people with a family history of multiple lentigines syndrome who want to have children.
Gibbs NF, Makkar HS. Disorders of Hyperpigmentation and Melanocytes. In: Eichenfield LF, Frieden IJ, Esterly NB, eds. Textbook of Neonatal Dermatology. 2nd Ed. Philadelphia, Pa: Saunders Elsevier; 2001: p. 196.
Updated by: Jonathan Kantor, MD, North Florida Dermatology Associates, Jacksonville, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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