Hemolytic crisis is the rapid destruction of large numbers of red blood cells (hemolysis). The destruction occurs much faster than the body can produce new red blood cells.
During a hemolytic crisis the body cannot make enough red blood cells to replace those that are destroyed.
The part of red blood cells that carries oxygen (hemoglobin) is released into the bloodstream, which can lead to kidney damage.
Causes of hemolysis include:
Call your doctor or nurse if you have:
Emergency treatment may be necessary. This may include a hospital stay, oxygen, blood transfusions, and other treatments.
When your condition is stable, your doctor or nurse will perform a physical examination and ask questions about your medical history and symptoms. The physical exam may occasionally show swelling of the spleen (splenomegaly).
Tests that may be done include:
Hemolysis - acute
Schwartz RS. Autoimmune and intravascular hemolytic anemias In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 163.
Gallagher PG. Hemolytic anemias: red cell membrane and metabolic defects In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 164.
Schrier SL, Price EA. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ, Shattil SS, et al., eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 48.
Updated by: Todd Gersten, MD, Hematology/Oncology, Palm Beach Cancer Institute, West Palm Beach, FL. Review provided by VeriMed Healthcare Network. Also reviewed by Linda J. Vorvick, MD, Medical Director and Director of Didactic Curriculum, MEDEX Northwest Division of Physician Assistant Studies, Department of Family Medicine, UW Medicine, School of Medicine, University of Washington; David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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