Acid mucopolysaccharides is a test that measures the amount of mucopolysaccharides released into the urine over a 24-hour period.
Mucopolysaccharides are long chains of sugar molecules in the body. They are often found in mucus and in fluid around the joints.
For this test, you must urinate into a special bag or container every time you use the bathroom for 24-hour period.
For an infant:
Thoroughly wash the area around the urethra (the hole where urine flows out). Open a urine collection bag (a plastic bag with an adhesive paper on one end).
Check the infant often, and change the bag after the infant has urinated. Empty the urine from the bag into the container provided by your doctor.
Active babies can move the bag causing the urine to go into the diaper. You may need extra collection bags.
When finished, label the container and return it as you have been told.
There is no special preparation needed.
The test involves only normal urination, and there is no discomfort.
This test is done to diagnose a rare group of genetic disorders called mucopolysaccharidoses (MPS). These include, Hurler, Scheie, and Hurler/Scheie syndromes (MPS I), Hunter syndrome (MPS II), Sanfilippo syndrome (MPS III), Morquio syndrome (MPS IV), Maroteaux-Lamy syndrome (MPS VI), and Sly syndrome (MPS VII).
Most of the time, this test is only done in infants who have a family history of one of these disorders.
Normal levels vary with age and from lab to lab. Talk to your doctor about the meaning of your specific test results.
Abnormally high levels could be consistent with a type of mucopolysaccharidosis. Further tests are needed to determine the specific type of mucopolysaccharidosis.
AMP; Dermatan sulfate - urine; Urine heparan sulfate; Urine dermatan sulfate; Heparan sulfate - urine
Updated by: Chad Haldeman-Englert, MD, FACMG, Wake Forest School of Medicine, Department of Pediatrics, Section on Medical Genetics, Winston-Salem, NC. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Bethanne Black, and the A.D.A.M. Editorial team.
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