Vasoactive intestinal polypeptide (VIP) is a substance found throughout the body. The highest levels are normally found in the nervous system and gut. VIP has many functions:
A blood test can be done to find out how much VIP you have in your blood.
A blood sample is needed. For information on how this is done, see: Venipuncture.
You should not eat or drink anything for 4 hours before the test.
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
This test is used to confirm the presence of a VIPoma, a tumor that releases VIP.
Normal values range from less than 75 - 190 pg/mL (picograms per milliliter).
Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.
The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.
A higher-than-normal level, along with symptoms of watery diarrhea and flushing, may be a sign of a VIPoma.
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
Jensen RT. Pancreatic endocrine tumors. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 205.
Updated by: Ari S. Eckman, MD, Chief, Division of Endocrinology, Diabetes and Metabolism, Trinitas Medical Center, Elizabeth, NJ. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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