This lab test measures the levels of proteins called globulins in the fluid (serum) part of a blood sample.
Other electrophoresis tests that measure proteins in the serum include:
A blood sample is needed.
At the lab, the technician places the blood sample on special paper and applies an electric current. The proteins move on the paper and form bands that show the amount of each protein.
You may be asked not to eat to drink (fast) for 4 hours before the test.
Certain medicines may affect the results of this test. Your doctor will tell you if you need to stop taking any medicines. Do not stop any medicine before talking to your doctor.
Medicines that can affect the test results include:
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
This test is done to look at globulin proteins in the blood. Identifying the types of globulins can help diagnose certain medical problems.
Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulines include various types of antibodies such as immunoglobulins (Ig) M, G, and A.
Certain diseases are associated with overproduction of immunoglobulins. For example, Waldenstrom macroglobulinemia is a cancer of certain white blood cells that is associated with the overproduction IgM antibodies.
Normal values ranges are:
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples.Talk to your doctor about the meaning of your specific test results.
Increased gamma globulin proteins may indicate:
There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
McPherson R. Specific proteins. In: McPherson RA, Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, Pa: Elsevier Saunders; 2011:chap 19.
Updated by: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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