Carpal tunnel biopsy is a test in which a small piece of tissue is removed from the carpal tunnel (part of the wrist).
The skin of your wrist is cleansed and injected with medicine that numbs the area. Through a small cut, a sample of tissue is removed from the carpal tunnel. This is done by direct removal of tissue or by needle aspiration.
Sometimes this procedure is done at the same time as carpal tunnel release.
Your doctor or nurse may ask that you not eat anything for a few hours before the test.
You may feel some stinging or burning when the numbing medicine is injected. You may also feel some pressure or tugging during the procedure. Afterward, the area may be tender or sore for a few days.
This test is usually done to see if you have a condition called amyloidosis. It is not usually done to diagnose carpal tunnel syndrome. However, a person with amyloidosis can have carpal tunnel syndrome.
No abnormal tissues are found.
An abnormal result is a sign of amyloidosis.
Risks of this procedure include:
Biopsy - carpal tunnel
Calandruccio JH. Carpal tunnel syndrome, ulnar tunnel syndrome, and stenosing tenosynovitis. In: Canale ST, Beaty JH, eds. Campbell's Operative Orthopaedics. 12th ed. Philadelphia, PA: Elsevier Mosby; 2012:chap 76.
Tosti R, Ilyas AM. Acute carpal tunnel syndrome. Orthop Clin N Am. 2012;43:459-465.
Updated by: C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
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