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NIH Researchers Identify OCD Risk Gene

Scientists at the NIH's National Institute on Alcohol Abuse and Alcoholism (NIAAA) have identified a previously unknown gene variant that doubles an individual's risk for obsessive-compulsive disorder (OCD). The new functional variant, or allele, is a component of the serotonin transporter gene (SERT), site of action for the selective serotonin reuptake inhibitors (SSRIs) that are today's mainstay medications for OCD, other anxiety disorders and depression.

"Improved knowledge of SERT's role in OCD raises the possibility of improved screening, treatment and medications development for that disorder," said Ting-Kai Li, M.D., NIAAA Director. "It also provides an important clue to the neurobiologic basis of OCD and the compulsive behaviors often seen in other psychiatric diseases, including alcohol dependence."

Approximately 2 percent of U.S. adults (3.3 million people) have OCD, the fourth most prevalent mental health disorder in the United States. Individuals with OCD have intrusive, disturbing thoughts or images (obsessions) and perform rituals (compulsions) to prevent or banish those thoughts. Many other individuals demonstrate obsessive-compulsive behaviors that do not meet OCD diagnostic criteria but alter the individuals' lives.

Summer 2006 Issue: Page 27