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Cúrcuma


¿Qué es?

La cúrcuma es una planta. Probablemente la conoce mejor como el condimento principal en el curry. Tiene un sabor tibio, amargo y se usa frecuentemente para darle el sabor o el color a los polvos de curry, a las mostazas, a las mantequillas y a los quesos. Pero la raíz de la cúrcuma también se utiliza mucho para hacer medicina.

La cúrcuma se usa para la artritis, la acidez (dispepsia), el dolor de estómago, la diarrea, el gas intestinal, la hinchazón de estómago, la pérdida de apetito, la ictericia, los problemas del hígado y los trastornos de la vesícula biliar.

Se utiliza también para los dolores de cabeza, la bronquitis, los resfriados, las infecciones pulmonares, la fibromialgia, la lepra, la fiebre, los problemas de la menstruación y el cáncer. Otros usos incluyen el tratamiento de la depresión, la enfermedad de Alzheimer, la retención de agua, los gusanos y los problemas renales.

Algunas personas aplican la cúrcuma sobre la piel para el dolor, la tiña, los moretones, las mordeduras de sanguijuelas, las infecciones de los ojos, para los trastornos inflamatorios de la piel, los malestares en el interior de la boca y para las heridas infectadas.

En los alimentos y la fabricación, el aceite esencial de la cúrcuma se usa en los perfumes y su resina se utiliza como un agente saborizante y colorante en los alimentos.

No confunda la cúrcuma con la raíz Javanesa de cúrcuma (Curcuma zedotaria).

¿Qué tan efectivo es?

Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.

La clasificación de la eficacia para este producto es la siguiente:

Posiblemente eficaz para...

  • El malestar estomacal (dispepsia). Algunas investigaciones muestran que el tomar cúrcuma por vía oral podría mejorar el malestar estomacal.
  • La osteoartritis. Algunas investigaciones muestran que tomar algunos extractos de cúrcuma puede reducir el dolor causado por la osteoartritis de la rodilla. En un estudio, la cúrcuma funcionó tan bien como el ibuprofeno para reducir el dolor.

Insuficiente evidencia para hacer una determinación para...

  • El cáncer de la piel. Hay cierta evidencia que muestra que el aplicar un ungüento de cúrcuma podría ayudar a disminuir el olor y aliviar la comezón producidos por el cáncer de piel.
  • La artritis reumática (AR). La curcumina, un químico en la cúrcuma, podría ayudar a disminuir algunos de los síntomas de la AR.
  • La ictericia.
  • La hepatitis.
  • La diarrea.
  • La fibromialgia.
  • Los problemas del hígado y de la vesícula biliar.
  • El dolor de cabeza.
  • Los problemas de la menstruación.
  • El dolor.
  • La tiña.
  • Los moretones.
  • Las infecciones de los ojos.
  • Los problemas de la piel.
  • La enfermedad de Alzheimer.
  • Otras afecciones.
Se necesita más evidencia para calificar la cúrcuma para estos usos.

¿Cómo funciona?

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Los químicos en la cúrcuma podrían disminuir la hinchazón (inflamación).

¿Hay preocupación por la seguridad de su uso?

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La cúrcuma es PROBABLEMENTE SEGURA cuando se usa apropiadamente por adultos.

La cúrcuma en general no produce efectos secundarios significativos; sin embargo, algunas personas pueden experimentar dolor de estómago, náuseas, mareos o diarrea.

En un informe, una persona que consumió grandes cantidades de cúrcuma, mas de 1500 mg dos veces al día, experimentó un ritmo cardiaco peligrosamente anormal. Sin embargo, no está claro si la cúrcuma fue realmente la causante de este efecto secundario. Hasta que no se tenga más información, evite tomar dosis excesivamente altas de cúrcuma.

Advertencias y precauciones especiales:

Embarazo y lactancia: El tomar cúrcuma por vía oral en cantidades medicinales PROBABLEMENTE NO ES SEGURO durante el embarazo. Podría hacer que empezara la menstruación o estimular el útero poniendo en riesgo el embarazo. No tome cúrcuma si está embarazada.

No hay suficiente información para determinar la seguridad de la cúrcuma durante la lactancia. Es mejor no usarla.

Problemas de la vesícula biliar: La cúrcuma puede empeorar los problemas de la vesícula. No use la cúrcuma si tiene cálculos renales u obstrucción del conducto biliar.

Cirugía: La cúrcuma podría retardar la coagulación sanguínea. Puede causar más pérdida de sangre durante y después de una cirugía. Deje de tomar la cúrcuma por lo menos dos semanas antes de someterse a un procedimiento quirúrgico.

¿Existen interacciones con medicamentos?

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Moderadas

Tenga cuidado con esta combinación

Medicamentos que retardan la coagulación sanguínea (Medicamentos anticoagulantes / antiplaquetarios)
La cúrcuma podría retardar la coagulación sanguínea. El tomar cúrcuma junto con medicamentos que también retardan la coagulación podría aumentar las probabilidades de sufrir moretones y pérdida de sangre.

Algunos medicamentos que retardan la coagulación sanguínea incluyen aspirina, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, otros), ibuprofeno (Advil, Motrin, otros), naproxeno (Anaprox, Naprosyn, otros), dalteparina (Fragmin), enoxaparina (Lovenox), heparina, warfarina (Coumadin) y otros.

¿Existen interacciones con hierbas y suplementos?

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Hierbas y suplementos que podrían retardar la coagulación sanguínea
La cúrcuma podría retardar la coagulación sanguínea. El tomar cúrcuma junto con hierbas que también retardan la coagulación sanguínea podría aumentar las probabilidades de sufrir moretones y pérdida de sangre. Estas hierbas incluyen la angélica, el clavo de olor, la salvia, el ajo, el jengibre, el ginkgo, el ginseng Panax, y otras.

¿Existen interacciones con alimentos?

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No se conoce ninguna interacción con alimentos.

¿Qué dosis se utiliza?

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La siguiente dosis se ha estudiado en investigaciones científicas:

POR VÍA ORAL:
  • Para el malestar estomacal (dispepsia): 500 mg de cúrcuma cuatro veces al día.
  • Para la osteoartritis: 500 mg dos veces al día de un extracto de cúrcuma específico (Meriva, Indena); 500 mg cuatro veces al día, de un producto no comercial también se ha utilizado.

Otros nombres

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Curcuma aromatica, Curcuma domestica, Curcumae longa, Curcumae Longae Rhizoma, Curcumin, Curcumine, Curcuminoid, Curcuminoïde, Curcuminoïdes, Curcuminoids, Halada, Haldi, Haridra, Indian Saffron, Nisha, Pian Jiang Huang, Racine de Curcuma, Radix Curcumae, Rajani, Rhizoma Cucurmae Longae, Safran Bourbon, Safran de Batallita, Safran des Indes, Turmeric Root, Yu Jin.

Metodología

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Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología metodología (http://www.nlm.nih.gov/medlineplus/spanish/druginfo/natural/methodology-sp.html) de la Base exhaustiva de datos de medicamentos naturales.

Referencias

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Para ver todas las referencias de la página de Cúrcuma, por favor diríjase a http://www.nlm.nih.gov/medlineplus/spanish/druginfo/natural/662.html.
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  404. Teiten, M. H., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., and Diederich, M. Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. Int J Oncol 2011;38:603-611. View abstract.
  405. Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J. B., and Srichairatanakool, S. Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids. Med Chem 2011;7:62-69. View abstract.
  406. Lin, M. S., Hung, K. S., Chiu, W. T., Sun, Y. Y., Tsai, S. H., Lin, J. W., and Lee, Y. H. Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. Prog.Neuropsychopharmacol.Biol Psychiatry 6-1-2011;35:931-938. View abstract.
  407. Lin, J. and Chen, A. Curcumin diminishes the impacts of hyperglycemia on the activation of hepatic stellate cells by suppressing membrane translocation and gene expression of glucose transporter-2. Mol.Cell Endocrinol 2-20-2011;333:160-171. View abstract.
  408. Reynolds, J. V., Donohoe, C. L., and Doyle, S. L. Diet, obesity and cancer. Ir.J Med Sci 2011;180:521-527. View abstract.
  409. Ponnurangam, S., Mondalek, F. G., Govind, J., Subramaniam, D., Houchen, C. W., Anant, S., Pantazis, P., and Ramanujam, R. P. Urine and serum analysis of consumed curcuminoids using an IkappaB-luciferase surrogate marker assay. In Vivo 2010;24:861-864. View abstract.
  410. Madkor, H. R., Mansour, S. W., and Ramadan, G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011;105:1210-1217. View abstract.
  411. Weissenberger, J., Priester, M., Bernreuther, C., Rakel, S., Glatzel, M., Seifert, V., and Kogel, D. Dietary curcumin attenuates glioma growth in a syngeneic mouse model by inhibition of the JAK1,2/STAT3 signaling pathway. Clin Cancer Res 12-1-2010;16:5781-5795. View abstract.
  412. Kakkar, V., Singh, S., Singla, D., Sahwney, S., Chauhan, A. S., Singh, G., and Kaur, I. P. Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats. J Chromatogr.B Analyt.Technol Biomed.Life Sci 12-15-2010;878:3427-3431. View abstract.
  413. Folwarczna, J., Zych, M., and Trzeciak, H. I. Effects of curcumin on the skeletal system in rats. Pharmacol Rep. 2010;62:900-909. View abstract.
  414. Balakrishnan, S., Manoharan, S., Alias, L. M., and Nirmal, M. R. Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Indian J Biochem Biophys 2010;47:7-12. View abstract.
  415. Chen, L. X., He, Y. J., Zhao, S. Z., Wu, J. G., Wang, J. T., Zhu, L. M., Lin, T. T., Sun, B. C., and Li, X. R. Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther 1-15-2011;11:229-235. View abstract.
  416. Schrader, C., Schiborr, C., Frank, J., and Rimbach, G. Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Br J Nutr 2011;105:167-170. View abstract.
  417. Ma, J., Phillips, L., Wang, Y., Dai, T., LaPage, J., Natarajan, R., and Adler, S. G. Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC. BMC Complement Altern Med 2010;10:67. View abstract.
  418. Rogers, N. M., Kireta, S., and Coates, P. T. Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol. 2010;162:460-473. View abstract.
  419. Zhang, Y., Cao, H., Hu, Y. Y., Wang, H., and Zhang, C. J. Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis. Int J Mol.Med 2011;27:87-94. View abstract.
  420. Seo, S. W., Bae, G. S., Kim, S. G., Yun, S. W., Kim, M. S., Yun, K. J., Park, R. K., Song, H. J., and Park, S. J. Protective effects of Curcuma longa against cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. Int J Mol.Med 2011;27:53-61. View abstract.
  421. Maher, D. M., Bell, M. C., O'Donnell, E. A., Gupta, B. K., Jaggi, M., and Chauhan, S. C. Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Mol.Carcinog. 2011;50:47-57. View abstract.
  422. Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., and Bar-Sela, G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer 2010;62:1137-1141. View abstract.
  423. El-Beshbishy, H. A., Mohamadin, A. M., Nagy, A. A., and Abdel-Naim, A. B. Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin. Indian J Exp Biol 2010;48:280-288. View abstract.
  424. Kim, T. H., Jiang, H. H., Youn, Y. S., Park, C. W., Tak, K. K., Lee, S., Kim, H., Jon, S., Chen, X., and Lee, K. C. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. Int J Pharm 1-17-2011;403(1-2):285-291. View abstract.
  425. Tang, Y. and Chen, A. Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. Br J Pharmacol 2010;161:1137-1149. View abstract.
  426. Agarwal, B. B. Do dietary spices impair the patient-reported outcomes for stapled hemorrhoidopexy? A randomized controlled study. Surg Endosc. 2011;25:1535-1540. View abstract.
  427. Voznesens'ka, T. I., Bryzhina, T. M., Sukhina, V. S., Makohon, N. V., and Aleksieieva, I. M. [Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice]. Fiziol.Zh. 2010;56:96-101. View abstract.
  428. Ahmed, T., Gilani, A. H., Hosseinmardi, N., Semnanian, S., Enam, S. A., and Fathollahi, Y. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse 2011;65:572-582. View abstract.
  429. Sun, Z. J., Chen, G., Zhang, W., Hu, X., Liu, Y., Zhou, Q., Zhu, L. X., and Zhao, Y. F. Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-kappaB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaB kinase complex signaling axis in adenoid cystic carcinoma. Mol.Pharmacol 2011;79:106-118. View abstract.
  430. Khuwaja, G., Khan, M. M., Ishrat, T., Ahmad, A., Raza, S. S., Ashafaq, M., Javed, H., Khan, M. B., Khan, A., Vaibhav, K., Safhi, M. M., and Islam, F. Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Brain Res 1-12-2011;1368:254-263. View abstract.
  431. Rungseesantivanon, S., Thenchaisri, N., Ruangvejvorachai, P., and Patumraj, S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med 2010;10:57. View abstract.
  432. Singh, M. and Singh, N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol.Cell Biochem 2011;347(1-2):1-11. View abstract.
  433. Kakkar, V., Singh, S., Singla, D., and Kaur, I. P. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol.Nutr Food Res 2011;55:495-503. View abstract.
  434. Lima, C. F., Pereira-Wilson, C., and Rattan, S. I. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Mol.Nutr Food Res 2011;55:430-442. View abstract.
  435. Wickenberg, J., Ingemansson, S. L., and Hlebowicz, J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J 2010;9:43. View abstract.
  436. Patel, V. B., Misra, S., Patel, B. B., and Majumdar, A. P. Colorectal cancer: chemopreventive role of curcumin and resveratrol. Nutr Cancer 2010;62:958-967. View abstract.
  437. Wei, S., Xu, H., Xia, D., and Zhao, R. Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig. Domest.Anim Endocrinol 2010;39:231-239. View abstract.
  438. Lee, H. S., Li, L., Kim, H. K., Bilehal, D., Li, W., Lee, D. S., and Kim, Y. H. The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol.Biotechnol. 2010;20:1331-1338. View abstract.
  439. Bhartiya, U. S., Joseph, L. J., Raut, Y. S., and Rao, B. S. Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice. Indian J Exp Biol 2010;48:566-571. View abstract.
  440. Schiborr, C., Eckert, G. P., Weissenberger, J., Muller, W. E., Schwamm, D., Grune, T., Rimbach, G., and Frank, J. Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharm Biotechnol. 2010;11:861-867. View abstract.
  441. Singh, R. S., Das, U., Dimmock, J. R., and Alcorn, J. A general HPLC-UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices. J Chromatogr.B Analyt.Technol Biomed.Life Sci 10-15-2010;878:2796-2802. View abstract.
  442. Matteucci, A., Cammarota, R., Paradisi, S., Varano, M., Balduzzi, M., Leo, L., Bellenchi, G. C., De, Nuccio C., Carnovale-Scalzo, G., Scorcia, G., Frank, C., Mallozzi, C., Di Stasi, A. M., Visentin, S., and Malchiodi-Albedi, F. Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit. Invest Ophthalmol.Vis.Sci 2011;52:1070-1077. View abstract.
  443. Kanai, M., Yoshimura, K., Asada, M., Imaizumi, A., Suzuki, C., Matsumoto, S., Nishimura, T., Mori, Y., Masui, T., Kawaguchi, Y., Yanagihara, K., Yazumi, S., Chiba, T., Guha, S., and Aggarwal, B. B. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother.Pharmacol 2011;68:157-164. View abstract.
  444. Villegas, I., Sanchez-Fidalgo, S., and de la Lastra, C. A. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Mol.Nutr Food Res 2011;55:259-267. View abstract.
  445. Mehla, J., Reeta, K. H., Gupta, P., and Gupta, Y. K. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci 11-20-2010;87(19-22):596-603. View abstract.
  446. Prakobwong, S., Khoontawad, J., Yongvanit, P., Pairojkul, C., Hiraku, Y., Sithithaworn, P., Pinlaor, P., Aggarwal, B. B., and Pinlaor, S. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer 7-1-2011;129:88-100. View abstract.
  447. Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., and Patravale, V. Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99:4992-5010. View abstract.
  448. Karatepe, O., Acet, E., Battal, M., Adas, G., Kemik, A., Altiok, M., Kamali, G., Koculu, S., Catay, A., Kamali, S., and Karahan, S. Effects of glutamine and curcumin on bacterial translocation in jaundiced rats. World J Gastroenterol. 9-14-2010;16:4313-4320. View abstract.
  449. Sharma, S., Ying, Z., and Gomez-Pinilla, F. A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma. Exp Neurol. 2010;226:191-199. View abstract.
  450. Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., and Huang, B. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm 11-15-2010;400(1-2):211-220. View abstract.
  451. Yousef, M. I., Omar, S. A., El-Guendi, M. I., and Abdelmegid, L. A. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 2010;48:3246-3261. View abstract.
  452. Dayton, A., Selvendiran, K., Kuppusamy, M. L., Rivera, B. K., Meduru, S., Kalai, T., Hideg, K., and Kuppusamy, P. Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer Biol Ther 2010;10:1027-1032. View abstract.
  453. Sahebkar, A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil.Steril. 2010;94:e75-e76. View abstract.
  454. Wu, X., Xu, J., Huang, X., and Wen, C. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 2011;37:15-23. View abstract.
  455. Quiroga, A., Quiroga, P. L., Martinez, E., Soria, E. A., and Valentich, M. A. Anti-breast cancer activity of curcumin on the human oxidation-resistant cells ZR-75-1 with gamma-glutamyltranspeptidase inhibition. J Exp Ther Oncol 2010;8:261-266. View abstract.
  456. Mohankumar, S. and McFarlane, J. R. An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. Phytother Res 2011;25:396-401. View abstract.
  457. Sintara, K., Thong-Ngam, D., Patumraj, S., Klaikeaw, N., and Chatsuwan, T. Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats. World J Gastroenterol. 8-28-2010;16:4039-4046. View abstract.
  458. Yadav, B., Taurin, S., Rosengren, R. J., Schumacher, M., Diederich, M., Somers-Edgar, T. J., and Larsen, L. Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin. Bioorg.Med Chem 9-15-2010;18:6701-6707. View abstract.
  459. Yan, Y. D., Kim, D. H., Sung, J. H., Yong, C. S., and Choi, H. G. Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin. Int J Pharm 10-31-2010;399(1-2):116-120. View abstract.
  460. Hsu, Y. C., Chen, M. J., Yu, Y. M., Ko, S. Y., and Chang, C. C. Suppression of TGF-beta1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid. Arch Dermatol Res 2010;302:717-724. View abstract.
  461. Wright, L. E., Frye, J. B., Timmermann, B. N., and Funk, J. L. Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition. J Agric.Food Chem 9-8-2010;58:9498-9504. View abstract.
  462. Tan, X., Sidell, N., Mancini, A., Huang, R. P., Shenming, Wang, Horowitz, I. R., Liotta, D. C., Taylor, R. N., and Wieser, F. Multiple anticancer activities of EF24, a novel curcumin analog, on human ovarian carcinoma cells. Reprod.Sci 2010;17:931-940. View abstract.
  463. Vachharajani, V., Wang, S. W., Mishra, N., El, Gazzar M., Yoza, B., and McCall, C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010;17:407-416. View abstract.
  464. Wong, T. S., Chan, W. S., Li, C. H., Liu, R. W., Tang, W. W., Tsao, S. W., Tsang, R. K., Ho, W. K., Wei, W. I., and Chan, J. Y. Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin. Anticancer Res 2010;30:2851-2856. View abstract.
  465. Choi, H. Y., Lim, J. E., and Hong, J. H. Curcumin interrupts the interaction between the androgen receptor and Wnt/beta-catenin signaling pathway in LNCaP prostate cancer cells. Prostate Cancer Prostatic.Dis 2010;13:343-349. View abstract.
  466. Ibrahim, A., El-Meligy, A., Fetaih, H., Dessouki, A., Stoica, G., and Barhoumi, R. Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. In Vivo 2010;24:401-408. View abstract.
  467. Boonrao, M., Yodkeeree, S., Ampasavate, C., Anuchapreeda, S., and Limtrakul, P. The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells. Arch Pharm Res 2010;33:989-998. View abstract.
  468. Tang, Y. and Chen, A. Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 2010;151:4168-4177. View abstract.
  469. Setthacheewakul, S., Mahattanadul, S., Phadoongsombut, N., Pichayakorn, W., and Wiwattanapatapee, R. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm. 2010;76:475-485. View abstract.
  470. Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., and Appendino, G. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010;52(2 Suppl 1):55-62. View abstract.
  471. Banerjee, M., Singh, P., and Panda, D. Curcumin suppresses the dynamic instability of microtubules, activates the mitotic checkpoint and induces apoptosis in MCF-7 cells. FEBS J 2010;277:3437-3448. View abstract.
  472. Peeyush, Kumar T., Antony, S., Soman, S., Kuruvilla, K. P., George, N., and Paulose, C. S. Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats. Mol.Cell Endocrinol 1-1-2011;331:1-10. View abstract.
  473. Yang, M. W., Wang, T. H., Yan, P. P., Chu, L. W., Yu, J., Gao, Z. D., Li, Y. Z., and Guo, B. L. Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice. Phytomedicine. 1-15-2011;18(2-3):205-213. View abstract.
  474. Ammon, H. P. and Wahl, M. A. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7. View abstract.
  475. Larmonier, C. B., Midura-Kiela, M. T., Ramalingam, R., Laubitz, D., Janikashvili, N., Larmonier, N., Ghishan, F. K., and Kiela, P. R. Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease. Inflamm.Bowel.Dis 2011;17:503-515. View abstract.
  476. Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., and Kazeminejad, B. Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav 2010;96:378-385. View abstract.
  477. Biswas, J., Roy, S., Mukherjee, S., Sinha, D., and Roy, M. Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. Asian Pac.J Cancer Prev 2010;11:239-247. View abstract.
  478. Tang, H., Murphy, C. J., Zhang, B., Shen, Y., Van Kirk, E. A., Murdoch, W. J., and Radosz, M. Curcumin polymers as anticancer conjugates. Biomaterials 2010;31:7139-7149. View abstract.
  479. Bielak-Zmijewska, A., Sikora-Polaczek, M., Nieznanski, K., Mosieniak, G., Kolano, A., Maleszewski, M., Styrna, J., and Sikora, E. Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity. Cell Prolif. 2010;43:354-364. View abstract.
  480. Rai, B., Kaur, J., Jacobs, R., and Singh, J. Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. J Oral Sci. 2010;52:251-256. View abstract.
  481. Jena, S. and Chainy, G. B. Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L: -thyroxine-induced oxidative stress in rat renal cortex. Mol.Biol.Rep. 6-24-2010; View abstract.
  482. Yallapu, M. M., Jaggi, M., and Chauhan, S. C. Poly(beta-cyclodextrin)/Curcumin Self-Assembly: A Novel Approach to Improve Curcumin Delivery and its Therapeutic Efficacy in Prostate Cancer Cells. Macromol.Biosci. 6-22-2010; View abstract.
  483. Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., and Zhang, H. G. A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes. Mol.Ther. 6-22-2010; View abstract.
  484. Bharti, A. C., Panigrahi, A., Sharma, P. K., Gupta, N., Kumar, R., Shukla, S., Bhowmik, D. M., Agarwal, S. K., Guleria, S., and Mehra, N. K. Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Exp.Clin Transplant. 2010;8:161-171. View abstract.
  485. Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., Ataee, R., and Moghaddam, S. N. Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain. J Med.Food 6-16-2010; View abstract.
  486. Jutooru, I., Chadalapaka, G., Lei, P., and Safe, S. Inhibition of NF{kappa}B and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein downregulation. J Biol.Chem. 6-9-2010; View abstract.
  487. Ahmed, T., Enam, S. A., and Gilani, A. H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 6-9-2010; View abstract.
  488. Cemil, B., Topuz, K., Demircan, M. N., Kurt, G., Tun, K., Kutlay, M., Ipcioglu, O., and Kucukodaci, Z. Curcumin improves early functional results after experimental spinal cord injury. Acta Neurochir.(Wien.) 6-10-2010; View abstract.
  489. Tharakan, B., Hunter, F. A., Roy, Smythe W., and Childs, E. W. CURCUMIN INHIBITS REACTIVE OXYGEN SPECIES FORMATION AND VASCULAR HYPERPERMEABILITY FOLLOWING HEMORRHAGIC SHOCK. Clin Exp.Pharmacol Physiol 5-28-2010; View abstract.
  490. Pisano, M., Pagnan, G., Dettori, M. A., Cossu, S., Caffa, I., Sassu, I., Emionite, L., Fabbri, D., Cilli, M., Pastorino, F., Palmieri, G., Delogu, G., Ponzoni, M., and Rozzo, C. Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. Mol.Cancer 6-3-2010;9:137. View abstract.
  491. Suresh, D. and Srinivasan, K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med.Res 2010;131:682-691. View abstract.
  492. Kumar, T. P., Antony, S., Gireesh, G., George, N., and Paulose, C. S. Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. J Biomed.Sci. 2010;17:43. View abstract.
  493. Sharma, V., Nehru, B., Munshi, A., and Jyothy, A. Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. Methods Find.Exp.Clin Pharmacol 2010;32:227-232. View abstract.
  494. Ide, H., Tokiwa, S., Sakamaki, K., Nishio, K., Isotani, S., Muto, S., Hama, T., Masuda, H., and Horie, S. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate 7-1-2010;70:1127-1133. View abstract.
  495. Zhao, J. Y., Lu, N., Yan, Z., and Wang, N. SAHA and curcumin combinations co-enhance histone acetylation in human cancer cells but operate antagonistically in exerting cytotoxic effects. J Asian Nat.Prod.Res 2010;12:335-348. View abstract.
  496. Chen, Y., Liu, W. H., Chen, B. L., Fan, L., Han, Y., Wang, G., Hu, D. L., Tan, Z. R., Zhou, G., Cao, S., and Zhou, H. H. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann.Pharmacother. 2010;44:1038-1045. View abstract.
  497. Yadav, R. S., Shukla, R. K., Sankhwar, M. L., Patel, D. K., Ansari, R. W., Pant, A. B., Islam, F., and Khanna, V. K. Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats. Neurotoxicology 5-11-2010; View abstract.
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  499. Shahani, K., Swaminathan, S. K., Freeman, D., Blum, A., Ma, L., and Panyam, J. Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. Cancer Res 6-1-2010;70:4443-4452. View abstract.
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  503. Lee, J. C., Kinniry, P. A., Arguiri, E., Serota, M., Kanterakis, S., Chatterjee, S., Solomides, C. C., Javvadi, P., Koumenis, C., Cengel, K. A., and Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat.Res 2010;173:590-601. View abstract.
  504. Pinlaor, S., Prakobwong, S., Hiraku, Y., Pinlaor, P., Laothong, U., and Yongvanit, P. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment. Eur.J Pharmacol 7-25-2010;638(1-3):134-141. View abstract.
  505. He, L. F., Chen, H. J., Qian, L. H., Chen, G. Y., and Buzby, J. S. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain Res 6-21-2010;1339:60-69. View abstract.
  506. Jung, I. D., Jeong, Y. I., Lee, C. M., Noh, K. T., Jeong, S. K., Chun, S. H., Choi, O. H., Park, W. S., Han, J., Shin, Y. K., Kim, H. W., Yun, C. H., and Park, Y. M. COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells. Int.Immunopharmacol. 4-22-2010; View abstract.
  507. El Deen, N. A. and Eid, M. Efficacy of curcumin to reduce hepatic damage induced by alcohol and thermally treated oil in rats. Vet.Ital. 2010;46:83-92. View abstract.
  508. Lin, Y. C., Chen, H. W., Kuo, Y. C., Chang, Y. F., Lee, Y. J., and Hwang, J. J. Therapeutic efficacy evaluation of curcumin on human oral squamous cell carcinoma xenograft using multimodalities of molecular imaging. Am.J Chin Med. 2010;38:343-358. View abstract.
  509. Hua, W. F., Fu, Y. S., Liao, Y. J., Xia, W. J., Chen, Y. C., Zeng, Y. X., Kung, H. F., and Xie, D. Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. Eur.J Pharmacol 7-10-2010;637(1-3):16-21. View abstract.
  510. Abdel Fattah, E. A., Hashem, H. E., Ahmed, F. A., Ghallab, M. A., Varga, I., and Polak, S. Prophylactic role of curcumin against cyclosporine-induced nephrotoxicity: Histological and immunohistological study. Gen.Physiol Biophys. 2010;29:85-94. View abstract.
  511. Rinwa, P., Kaur, B., Jaggi, A. S., and Singh, N. Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia. Naunyn Schmiedebergs Arch.Pharmacol 2010;381:529-539. View abstract.
  512. Hilchie, A. L., Furlong, S. J., Sutton, K., Richardson, A., Robichaud, M. R., Giacomantonio, C. A., Ridgway, N. D., and Hoskin, D. W. Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria. Nutr.Cancer 2010;62:379-389. View abstract.
  513. Okazaki, Y., Han, Y., Kayahara, M., Watanabe, T., Arishige, H., and Kato, N. Consumption of curcumin elevates fecal immunoglobulin a, an index of intestinal immune function, in rats fed a high-fat diet. J Nutr.Sci.Vitaminol.(Tokyo) 2010;56:68-71. View abstract.
  514. Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20:2549-2551. View abstract.
  515. Wu, H., Hsieh, M. C., Lo, C. Y., Liu, C. B., Sang, S., Ho, C. T., and Pan, M. H. 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. Mol.Nutr.Food Res 3-24-2010; View abstract.
  516. Baghdasaryan, A., Claudel, T., Kosters, A., Gumhold, J., Silbert, D., Thuringer, A., Leski, K., Fickert, P., Karpen, S. J., and Trauner, M. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 2010;59:521-530. View abstract.
  517. Hashem, M. M., Atta, A. H., Arbid, M. S., Nada, S. A., and Asaad, G. F. Immunological studies on Amaranth, Sunset Yellow and Curcumin as food colouring agents in albino rats. Food Chem.Toxicol 2010;48:1581-1586. View abstract.
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  519. Yu, S., Zheng, W., Xin, N., Chi, Z. H., Wang, N. Q., Nie, Y. X., Feng, W. Y., and Wang, Z. Y. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation.Res 2010;13:55-64. View abstract.
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  522. Pyrzanowska, J., Piechal, A., Blecharz-Klin, K., Lehner, M., Skorzewska, A., Turzynska, D., Sobolewska, A., Plaznik, A., and Widy-Tyszkiewicz, E. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacol Biochem.Behav. 2010;95:351-358. View abstract.
  523. Kim, J. H., Park, J. M., Kim, E. K., Lee, J. O., Lee, S. K., Jung, J. H., You, G. Y., Park, S. H., Suh, P. G., and Kim, H. S. Curcumin stimulates glucose uptake through AMPK-p38 MAPK pathways in L6 myotube cells. J Cell Physiol 2010;223:771-778. View abstract.
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  525. Moon, D. O., Kim, M. O., Choi, Y. H., Park, Y. M., and Kim, G. Y. Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model. Int.Immunopharmacol. 2010;10:605-610. View abstract.
  526. Sharma, P. and Singh, R. Protective role of curcumin on lindane induced reproductive toxicity in male Wistar rats. Bull.Environ.Contam Toxicol 2010;84:378-384. View abstract.
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  528. Cheng, T. C., Lu, C. C., Chung, H. H., Hsu, C. C., Kakizawa, N., Yamada, S., and Cheng, J. T. Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats. Neurosci.Lett. 4-5-2010;473:107-109. View abstract.
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  530. Manikandan, R., Thiagarajan, R., Beulaja, S., Sudhandiran, G., and Arumugam, M. Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups. Curr.Eye Res 2010;35:122-129. View abstract.
  531. Laird, M. D., Sukumari-Ramesh, S., Swift, A. E., Meiler, S. E., Vender, J. R., and Dhandapani, K. M. Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4? J Neurochem. 5-1-2010;113:637-648. View abstract.
  532. Wu, S. J., Tam, K. W., Tsai, Y. H., Chang, C. C., and Chao, J. C. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am.J Chin Med. 2010;38:99-111. View abstract.
  533. Chang, K. W., Hung, P. S., Lin, I. Y., Hou, C. P., Chen, L. K., Tsai, Y. M., and Lin, S. C. Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression. Int.J Cancer 7-1-2010;127:9-20. View abstract.
  534. Tanwar, V., Sachdeva, J., Golechha, M., Kumari, S., and Arya, D. S. Curcumin protects rat myocardium against isoproterenol-induced ischemic injury: attenuation of ventricular dysfunction through increased expression of Hsp27 along with strengthening antioxidant defense system. J Cardiovasc.Pharmacol 2010;55:377-384. View abstract.
  535. El Agamy, D. S. Comparative effects of curcumin and resveratrol on aflatoxin B-induced liver injury in rats. Arch.Toxicol 2010;84:389-396. View abstract.
  536. Gota, V. S., Maru, G. B., Soni, T. G., Gandhi, T. R., Kochar, N., and Agarwal, M. G. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric.Food Chem 2-24-2010;58:2095-2099. View abstract.
  537. Fong, D., Yeh, A., Naftalovich, R., Choi, T. H., and Chan, M. M. Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals. Cancer Lett. 7-1-2010;293:65-72. View abstract.
  538. Perry, M. C., Demeule, M., Regina, A., Moumdjian, R., and Beliveau, R. Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts. Mol.Nutr.Food Res 1-19-2010; View abstract.
  539. Becatti, M., Prignano, F., Fiorillo, C., Pescitelli, L., Nassi, P., Lotti, T., and Taddei, N. The Involvement of Smac/DIABLO, p53, NF-kB, and MAPK Pathways in Apoptosis of Keratinocytes from Perilesional Vitiligo Skin: Protective Effects of Curcumin and Capsaicin. Antioxid.Redox.Signal. 4-20-2010; View abstract.
  540. Bao, W., Li, K., Rong, S., Yao, P., Hao, L., Ying, C., Zhang, X., Nussler, A., and Liu, L. Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction. J Ethnopharmacol. 3-24-2010;128:549-553. View abstract.
  541. Wang, B. M., Zhai, C. Y., Fang, W. L., Chen, X., Jiang, K., and Wang, Y. M. [The inhibitory effect of curcumin on the proliferation of HT-29 colonic cancer cell induced by deoxycholic acid]. Zhonghua Nei Ke.Za Zhi. 2009;48:760-763. View abstract.
  542. Yu, Z. G., Xu, N., Wang, W. B., Pan, S. H., Li, K. S., and Liu, J. K. Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin Med.J (Engl) 10-20-2009;122:2483-2488. View abstract.
  543. Su, C. C., Yang, J. S., Lu, C. C., Chiang, J. H., Wu, C. L., Lin, J. J., Lai, K. C., Hsia, T. C., Lu, H. F., Fan, M. J., and Chung, J. G. Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model. Phytother.Res 2010;24:189-192. View abstract.
  544. Shinkai, Y., Yamamoto, C., and Kaji, T. Lead induces the expression of endoplasmic reticulum chaperones GRP78 and GRP94 in vascular endothelial cells via the JNK-AP-1 pathway. Toxicol Sci. 2010;114:378-386. View abstract.
  545. Varghese, K., Molnar, P., Das, M., Bhargava, N., Lambert, S., Kindy, M. S., and Hickman, J. J. A new target for amyloid beta toxicity validated by standard and high-throughput electrophysiology. PLoS.One. 2010;5:e8643. View abstract.
  546. Smith, M. R., Gangireddy, S. R., Narala, V. R., Hogaboam, C. M., Standiford, T. J., Christensen, P. J., Kondapi, A. K., and Reddy, R. C. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am.J Physiol Lung Cell Mol.Physiol 1-8-2010; View abstract.
  547. Kwon, S. J., Kim, M. I., Ku, B., Coulombel, L., Kim, J. H., Shawky, J. H., Linhardt, R. J., and Dordick, J. S. Unnatural polyketide analogues selectively target the HER signaling pathway in human breast cancer cells. Chembiochem. 3-1-2010;11:573-580. View abstract.
  548. Dairaku, I., Han, Y., Yanaka, N., and Kato, N. Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents. Biosci.Biotechnol.Biochem. 2010;74:185-187. View abstract.
  549. Bansal, S. and Chhibber, S. Curcumin alone and in combination with augmentin protects against pulmonary inflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice. J Med.Microbiol. 2010;59(Pt 4):429-437. View abstract.
  550. Biswas, J., Sinha, D., Mukherjee, S., Roy, S., Siddiqi, M., and Roy, M. Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal. Hum.Exp.Toxicol 2010;29:513-524. View abstract.
  551. Wang, W. Z., Zhang, B. Y., Mei, W. J., Mao, J. W., and Li, M. [Effect of p21-targeted shRNA on curcumin-induced apoptosis of human hepatoma Huh7 cells]. Yao Xue.Xue.Bao. 2009;44:1102-1106. View abstract.
  552. Sou, K., Oyajobi, B., Goins, B., Phillips, W. T., and Tsuchida, E. Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol). J Biomed.Nanotechnol. 2009;5:202-208. View abstract.
  553. Singla, N. and Dhawan, D. K. Modulation of carbohydrate metabolism during N-methyl N-nitrosourea induced neurotoxicity in mice: role of curcumin. Neurochem.Res 2010;35:660-665. View abstract.
  554. Mendonca, L. M., Dos Santos, G. C., Dos Santos, R. A., Takahashi, C. S., Bianchi, M. D., and Antunes, L. M. Evaluation of curcumin and cisplatin-induced DNA damage in PC12 cells by the alkaline comet assay. Hum.Exp.Toxicol 1-5-2010; View abstract.
  555. Antony, B., Merina, B., Iyer, V. S., Judy, N., Lennertz, K., and Joyal, S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008;70:445-449. View abstract.
  556. Lee, D. S., Lee, M. K., and Kim, J. H. Curcumin induces cell cycle arrest and apoptosis in human osteosarcoma (HOS) cells. Anticancer Res 2009;29:5039-5044. View abstract.
  557. Huang, W. Y., Cai, Y. Z., and Zhang, Y. Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr.Cancer 2010;62:1-20. View abstract.
  558. Chen, Q., Wang, Y., Xu, K., Lu, G., Ying, Z., Wu, L., Zhan, J., Fang, R., Wu, Y., and Zhou, J. Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Oncol.Rep. 2010;23:397-403. View abstract.
  559. Singh, R., Singh, N., Saini, B. S., and Rao, H. S. In vitro antioxidant activity of pet ether extract of black pepper. Indian J Pharmacol 2008;40:147-151. View abstract.
  560. Yeon, K. Y., Kim, S. A., Kim, Y. H., Lee, M. K., Ahn, D. K., Kim, H. J., Kim, J. S., Jung, S. J., and Oh, S. B. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent.Res 2010;89:170-174. View abstract.
  561. Giommarelli, C., Zuco, V., Favini, E., Pisano, C., Dal Piaz, F., De Tommasi, N., and Zunino, F. The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol.Life Sci. 2010;67:995-1004. View abstract.
  562. Bachmeier, B. E., Killian, P., Pfeffer, U., and Nerlich, A. G. Novel aspects for the application of Curcumin in chemoprevention of various cancers. Front Biosci.(Schol.Ed) 2010;2:697-717. View abstract.
  563. Yoon, M. J., Kim, E. H., Lim, J. H., Kwon, T. K., and Choi, K. S. Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells. Free Radic.Biol.Med. 3-1-2010;48:713-726. View abstract.
  564. Singh, R. K., Rai, D., Yadav, D., Bhargava, A., Balzarini, J., and De Clercq, E. Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid. Eur.J Med.Chem. 2010;45:1078-1086. View abstract.
  565. Goergens, A., Frericks, M., and Esser, C. The arylhydrocarbon receptor is only marginally involved in the antileukemic effects of its ligand curcumin. Anticancer Res 2009;29:4657-4664. View abstract.
  566. Bachmeier, B. E., Iancu, C. M., Killian, P. H., Kronski, E., Mirisola, V., Angelini, G., Jochum, M., Nerlich, A. G., and Pfeffer, U. Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells. Mol.Cancer 2009;8:129. View abstract.
  567. Tanwar, V., Sachdeva, J., Kishore, K., Mittal, R., Nag, T. C., Ray, R., Kumari, S., and Arya, D. S. Dose-dependent actions of curcumin in experimentally induced myocardial necrosis: a biochemical, histopathological, and electron microscopic evidence. Cell Biochem.Funct. 2010;28:74-82. View abstract.
  568. Hemeida, R. A. and Mohafez, O. M. Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats. J Egypt Natl.Canc.Inst. 2008;20:141-148. View abstract.
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  570. Chen, M., Hu, D. N., Pan, Z., Lu, C. W., Xue, C. Y., and Aass, I. Curcumin protects against hyperosmoticity-induced IL-1beta elevation in human corneal epithelial cell via MAPK pathways. Exp.Eye Res 2010;90:437-443. View abstract.
  571. Agrawal, R., Mishra, B., Tyagi, E., Nath, C., and Shukla, R. Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat. Pharmacol Res 2010;61:247-252. View abstract.
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  573. Hsu, C. L., Yu, Y. S., and Yen, G. C. Anticancer effects of Alpinia pricei Hayata roots. J Agric.Food Chem. 2-24-2010;58:2201-2208. View abstract.
  574. Funk, J. L., Frye, J. B., Oyarzo, J. N., Zhang, H., and Timmermann, B. N. Anti-arthritic effects and toxicity of the essential oils of turmeric (Curcuma longa L.). J Agric.Food Chem. 1-27-2010;58:842-849. View abstract.
  575. Elamin, M. H., Shinwari, Z., Hendrayani, S. F., Al Hindi, H., Al Shail, E., Khafaga, Y., Al Kofide, A., and Aboussekhra, A. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Mol.Carcinog. 2010;49:302-314. View abstract.
  576. Manikandan, R., Thiagarajan, R., Beulaja, S., Sudhandiran, G., and Arumugam, M. Curcumin protects against hepatic and renal injuries mediated by inducible nitric oxide synthase during selenium-induced toxicity in Wistar rats. Microsc.Res Tech. 2010;73:631-637. View abstract.
  577. Kalpana, C. and Menon, V. P. Protective effect of curcumin on circulatory lipid peroxidation and antioxidant status during nicotine-induced toxicity. Toxicol Mech.Methods 2004;14:339-343. View abstract.
  578. Hu, Y. B., Lin, Z., Feng, D. Y., Li, X., Chu, L., Jiang, H. Y., and Peng, J. W. Silica Induces Plasminogen Activator Inhibitor-1 Expression through a MAPKs/AP-1-Dependent Mechanism in Human Lung Epithelial Cells. Toxicol Mech.Methods 2008;18:561-567. View abstract.
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  580. Zhang, L., Wu, C., Zhao, S., Yuan, D., Lian, G., Wang, X., Wang, L., and Yang, J. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-kappaB signaling pathways in N9 microglia induced by lipopolysaccharide. Int.Immunopharmacol. 2010;10:331-338. View abstract.
  581. Sharma, M., Manoharlal, R., Puri, N., and Prasad, R. Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans. Biosci.Rep. 12-17-2009; View abstract.
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  583. Fiala, M. Re-Balancing of Inflammation and A Immunity as a Therapeutic for Alzheimer's Disease-View from the Bedside. CNS.Neurol.Disord.Drug Targets. 10-7-2009; View abstract.
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  585. Koizume, S., Yokota, N., Miyagi, E., Hirahara, F., Nakamura, Y., Sakuma, Y., Yoshida, A., Kameda, Y., Tsuchiya, E., Ruf, W., and Miyagi, Y. Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases. Mol.Cancer Res 2009;7:1928-1936. View abstract.
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  587. Yao, J., Zhang, Q., Min, J., He, J., and Yu, Z. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Bioorg.Med.Chem.Lett. 1-1-2010;20:56-59. View abstract.
  588. Ning, L., Wentworth, L., Chen, H., and Weber, S. M. Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma. Am.J Transl.Res 2009;1:358-366. View abstract.
  589. Panicker, S. R. and Kartha, C. C. Curcumin attenuates glucose-induced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factor-kappaB pathway. Pharmacology 2010;85:18-26. View abstract.
  590. Prasad, C. P., Rath, G., Mathur, S., Bhatnagar, D., and Ralhan, R. Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines. Chem.Biol.Interact. 2-12-2010;183:455-461. View abstract.
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  603. Karatepe, O., Gulcicek, O. B., Ugurlucan, M., Adas, G., Battal, M., Kemik, A., Kamali, G., Altug, T., and Karahan, S. Curcumin nutrition for the prevention of mesenteric ischemia-reperfusion injury: an experimental rodent model. Transplant.Proc. 2009;41:3611-3616. View abstract.
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  607. Yarru, L. P., Settivari, R. S., Gowda, N. K., Antoniou, E., Ledoux, D. R., and Rottinghaus, G. E. Effects of turmeric (Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant, and immune systems in broiler chicks fed aflatoxin. Poult.Sci. 2009;88:2620-2627. View abstract.
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  609. Kamat, A. M., Tharakan, S. T., Sung, B., and Aggarwal, B. B. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res 12-1-2009;69:8958-8966. View abstract.
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  613. Bayet-Robert, M., Kwiatkowski, F., Leheurteur, M., Gachon, F., Planchat, E., Abrial, C., Mouret-Reynier, M. A., Durando, X., Barthomeuf, C., and Chollet, P. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol.Ther. 2010;9:8-14. View abstract.
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  622. Epstein, J., Docena, G., Macdonald, T. T., and Sanderson, I. R. Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease. Br.J Nutr. 2010;103:824-832. View abstract.
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  624. Leite, K. R., Chade, D. C., Sanudo, A., Sakiyama, B. Y., Batocchio, G., and Srougi, M. Effects of curcumin in an orthotopic murine bladder tumor model. Int.Braz.J Urol. 2009;35:599-606. View abstract.
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  626. Singh, M., Pandey, A., Karikari, C. A., Singh, G., and Rakheja, D. Cell cycle inhibition and apoptosis induced by curcumin in Ewing sarcoma cell line SK-NEP-1. Med.Oncol. 10-27-2009; View abstract.
  627. Yun, S. S., Kim, S. P., Kang, M. Y., and Nam, S. H. Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock. Biotechnol.Lett. 2010;32:209-214. View abstract.
  628. Muthenna, P., Suryanarayana, P., Gunda, S. K., Petrash, J. M., and Reddy, G. B. Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance. FEBS Lett. 11-19-2009;583:3637-3642. View abstract.
  629. Mukerjee, A. and Vishwanatha, J. K. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 2009;29:3867-3875. View abstract.
  630. Lin, J., Zheng, S., and Chen, A. Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress. Lab Invest 2009;89:1397-1409. View abstract.
  631. Cong, Y., Wang, L., Konrad, A., Schoeb, T., and Elson, C. O. Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells. Eur.J Immunol. 2009;39:3134-3146. View abstract.
  632. Henrotin, Y., Clutterbuck, A. L., Allaway, D., Lodwig, E. M., Harris, P., Mathy-Hartert, M., Shakibaei, M., and Mobasheri, A. Biological actions of curcumin on articular chondrocytes. Osteoarthritis.Cartilage. 2010;18:141-149. View abstract.
  633. Sirat, H. M., Jamil, S., and Rahman, A. A. Sesquiterpenes from the rhizomes of Curcuma ochrorhiza. Nat.Prod.Commun. 2009;4:1171. View abstract.
  634. Burgos-Moron, E., Calderon-Montano, J. M., Salvador, J., Robles, A., and Lopez-Lazaro, M. The dark side of curcumin. Int.J Cancer 4-1-2010;126:1771-1775. View abstract.
  635. Onoue, S., Takahashi, H., Kawabata, Y., Seto, Y., Hatanaka, J., Timmermann, B., and Yamada, S. Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J Pharm Sci. 2010;99:1871-1881. View abstract.
  636. Chen, L., Tian, G., Shao, C., Cobos, E., and Gao, W. Curcumin modulates eukaryotic initiation factors in human lung adenocarcinoma epithelial cells. Mol.Biol.Rep. 10-15-2009; View abstract.
  637. Das, T., Sa, G., Saha, B., and Das, K. Multifocal signal modulation therapy of cancer: ancient weapon, modern targets. Mol.Cell Biochem. 2010;336(1-2):85-95. View abstract.
  638. Ciftci, O., Tanyildizi, S., and Godekmerdan, A. Protective effect of curcumin on immune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). Immunopharmacol.Immunotoxicol. 2010;32:99-104. View abstract.
  639. Yodkeeree, S., Ampasavate, C., Sung, B., Aggarwal, B. B., and Limtrakul, P. Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. Eur.J Pharmacol 2-10-2010;627(1-3):8-15. View abstract.
  640. Garg, R. and Maru, G. Dietary curcumin enhances benzo(a)pyrene-induced apoptosis resulting in a decrease in BPDE-DNA adducts in mice. J Environ.Pathol.Toxicol Oncol. 2009;28:121-131. View abstract.
  641. Somers-Edgar, T. J., Taurin, S., Larsen, L., Chandramouli, A., Nelson, M. A., and Rosengren, R. J. Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines. Invest New Drugs 10-9-2009; View abstract.
  642. Rivera-Espinoza, Y. and Muriel, P. Pharmacological actions of curcumin in liver diseases or damage. Liver Int. 2009;29:1457-1466. View abstract.
  643. Gupta, Y. K., Briyal, S., and Sharma, M. Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. Indian J Physiol Pharmacol 2009;53:39-46. View abstract.
  644. Rowe, D. L., Ozbay, T., O'Regan, R. M., and Nahta, R. Modulation of the BRCA1 protein and induction of apoptosis in triple negative breast cancer cell lines by the polyphenolic compound curcumin. Breast Cancer 9-2-2009;3:61-75. View abstract.
  645. O'Sullivan-Coyne, G., O'Sullivan, G. C., O'Donovan, T. R., Piwocka, K., and McKenna, S. L. Curcumin induces apoptosis-independent death in oesophageal cancer cells. Br.J Cancer 11-3-2009;101:1585-1595. View abstract.
  646. Kang, Q. and Chen, A. Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology 2009;150:5384-5394. View abstract.
  647. Teiten, M. H., Gaascht, F., Eifes, S., Dicato, M., and Diederich, M. Chemopreventive potential of curcumin in prostate cancer. Genes Nutr. 2010;5:61-74. View abstract.
  648. Peeyush, K. T., Gireesh, G., Jobin, M., and Paulose, C. S. Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Life Sci. 11-4-2009;85(19-20):704-710. View abstract.
  649. Li, W., Xiao, H., Wang, L., and Liang, X. [Analysis of minor curcuminoids in Curcuma longa L. by high performance liquid chromatography-tandem mass spectrometry]. Se.Pu. 2009;27:264-269. View abstract.
  650. Shen, L. and Ji, H. F. Insights into the inhibition of xanthine oxidase by curcumin. Bioorg.Med.Chem.Lett. 11-1-2009;19:5990-5993. View abstract.
  651. Ali, S., Singh, N. N., Yildirim, H., and Ramji, D. P. Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. Int.J Biochem.Cell Biol. 2010;42:113-119. View abstract.
  652. Moghaddam, S. J., Barta, P., Mirabolfathinejad, S. G., Ammar-Aouchiche, Z., Garza, N. T., Vo, T. T., Newman, R. A., Aggarwal, B. B., Evans, C. M., Tuvim, M. J., Lotan, R., and Dickey, B. F. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009;30:1949-1956. View abstract.
  653. Reddy, B. V., Sivagama, Sundari J., Balamurugan, E., and Menon, V. P. Antihyperlipidemic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione, a curcumin analog, on nicotine and streptozotocin treated rats. Mol.Cell Biochem. 2010;335(1-2):249-254. View abstract.
  654. Agrawal, S. S. and Ittiyavirah, S. P. Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats. Immunopharmacol.Immunotoxicol. 2010;32:92-98. View abstract.
  655. Totlandsdal, A. I., Refsnes, M., and Lag, M. Mechanisms involved in ultrafine carbon black-induced release of IL-6 from primary rat epithelial lung cells. Toxicol In Vitro 2010;24:10-20. View abstract.
  656. Tang, Y. H., Bao, M. W., Yang, B., Zhang, Y., Zhang, B. S., Zhou, Q., Chen, J. L., and Huang, C. X. [Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure.]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 2009;37:262-267. View abstract.
  657. Wang, L., Shen, Y., Song, R., Sun, Y., Xu, J., and Xu, Q. An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol.Pharmacol 2009;76:1238-1245. View abstract.
  658. Shin, H. K., Kim, J., Lee, E. J., and Kim, S. H. Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD-10B cells via suppression of ERK and NF-kappaB activations. Phytother.Res 2010;24:577-582. View abstract.
  659. Hsu, J. L., Chiang, P. C., and Guh, J. H. Tunicamycin induces resistance to camptothecin and etoposide in human hepatocellular carcinoma cells: role of cell-cycle arrest and GRP78. Naunyn Schmiedebergs Arch.Pharmacol 2009;380:373-382. View abstract.
  660. Wang, Y., Lu, Z., Wu, H., and Lv, F. Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens. Int.J Food Microbiol. 11-30-2009;136:71-74. View abstract.
  661. Zhao, J., Yu, S., Zheng, W., Feng, G., Luo, G., Wang, L., and Zhao, Y. Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochem.Res 2010;35:374-379. View abstract.
  662. Fernandez-Martinez, A. B., Bajo, A. M., Valdehita, A., Isabel, Arenas M., Sanchez-Chapado, M., Carmena, M. J., and Prieto, J. C. Multifunctional role of VIP in prostate cancer progression in a xenograft model: suppression by curcumin and COX-2 inhibitor NS-398. Peptides 2009;30:2357-2364. View abstract.
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  665. Tang, Z., Yang, L., Xue, R., Zhang, J., Wang, Y., Chen, P. C., and Sung, K. L. Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after a mechanical injury: involvement of the p65 subunit of NF-kappaB. Wound.Repair Regen. 2009;17:709-716. View abstract.
  666. Lim, J. H. and Kwon, T. K. Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Food Chem.Toxicol 2010;48:47-52. View abstract.
  667. Reeta, K. H., Mehla, J., and Gupta, Y. K. Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. Brain Res 12-8-2009;1301:52-60. View abstract.
  668. Cheng, T. C., Lin, C. S., Hsu, C. C., Chen, L. J., Cheng, K. C., and Cheng, J. T. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Neurosci.Lett. 11-20-2009;465:238-241. View abstract.
  669. Shi, J. Q., Xie, M., Wang, Y. J., Ling, W., and Wang, H. L. [The effect or rosiglitazone on signal pathways of transforming growth factor-beta1 in human lung fibroblast]. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. 2009;40:598-603. View abstract.
  670. Schrenk, D. Dietary fiber, low-molecular-weight food constituents and colo-rectal inflammation in animal models -- a review. Mol.Nutr.Food Res 2009;53:1281-1288. View abstract.
  671. Mun, S. H., Kim, H. S., Kim, J. W., Ko, N. Y., Kim, do K., Lee, B. Y., Kim, B., Won, H. S., Shin, H. S., Han, J. W., Lee, H. Y., Kim, Y. M., and Choi, W. S. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci. 2009;111:13-21. View abstract.
  672. Hushmendy, S., Jayakumar, L., Hahn, A. B., Bhoiwala, D., Bhoiwala, D. L., and Crawford, D. R. Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation. Nutr.Res 2009;29:568-578. View abstract.
  673. Patel, S. S., Shah, R. S., and Goyal, R. K. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp.Biol. 2009;47:564-570. View abstract.
  674. Takahashi, M., Uechi, S., Takara, K., Asikin, Y., and Wada, K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric.Food Chem. 10-14-2009;57:9141-9146. View abstract.
  675. Xiao, H., Xiao, Q., Zhang, K., Zuo, X., and Shrestha, U. K. Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R. Ann.Hematol. 2010;89:399-404. View abstract.
  676. Pinlaor, S., Yongvanit, P., Prakobwong, S., Kaewsamut, B., Khoontawad, J., Pinlaor, P., and Hiraku, Y. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol.Nutr.Food Res 2009;53:1316-1328. View abstract.
  677. Lee, J. H. and Chung, I. K. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 4-1-2010;290:76-86. View abstract.
  678. Nardo, L., Andreoni, A., Bondani, M., Masson, M., and Hjorth, Tonnesen H. Studies on curcumin and curcuminoids. XXXIV. Photophysical properties of a symmetrical, non-substituted curcumin analogue. J Photochem.Photobiol.B 11-9-2009;97:77-86. View abstract.
  679. Hong, D., Zeng, X., Xu, W., Ma, J., Tong, Y., and Chen, Y. Altered profiles of gene expression in curcumin-treated rats with experimentally induced myocardial infarction. Pharmacol Res 2010;61:142-148. View abstract.
  680. Bernard, K., Wang, W., Narlawar, R., Schmidt, B., and Kirk, K. L. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol.Chem. 11-6-2009;284:30754-30765. View abstract.
  681. Golombick, T., Diamond, T. H., Badmaev, V., Manoharan, A., and Ramakrishna, R. The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker. Clin Cancer Res 9-15-2009;15:5917-5922. View abstract.
  682. Feng, J. Y. and Liu, Z. Q. Phenolic and enolic hydroxyl groups in curcumin: which plays the major role in scavenging radicals? J Agric.Food Chem. 11-25-2009;57:11041-11046. View abstract.
  683. Kang, Q. and Chen, A. Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1. Lab Invest 2009;89:1275-1290. View abstract.
  684. Sandur, S. K., Deorukhkar, A., Pandey, M. K., Pabon, A. M., Shentu, S., Guha, S., Aggarwal, B. B., and Krishnan, S. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int.J Radiat.Oncol.Biol.Phys. 10-1-2009;75:534-542. View abstract.
  685. Anand, P., Nair, H. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., Tekmal, R. R., and Aggarwal, B. B. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem.Pharmacol 2-1-2010;79:330-338. View abstract.
  686. Choi, K. H., Park, J. W., Kim, H. Y., Kim, Y. H., Kim, S. M., Son, Y. H., Park, Y. C., Eo, S. K., and Kim, K. Cellular factors involved in CXCL8 expression induced by glycated serum albumin in vascular smooth muscle cells. Atherosclerosis 2010;209:58-65. View abstract.
  687. Leow, P. C., Tian, Q., Ong, Z. Y., Yang, Z., and Ee, P. L. Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/beta-catenin antagonists against human osteosarcoma cells. Invest New Drugs 9-3-2009; View abstract.
  688. Schaaf, C., Shan, B., Buchfelder, M., Losa, M., Kreutzer, J., Rachinger, W., Stalla, G. K., Schilling, T., Arzt, E., Perone, M. J., and Renner, U. Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo. Endocr.Relat Cancer 2009;16:1339-1350. View abstract.
  689. Zhuang, R., Lin, M. X., Song, Q. Y., and Li, J. [Effects of curcumin on the expression of nuclear factor-kappaB and intercellular adhesion molecular 1 in rats with cerebral ischemia-reperfusion injury]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2009;29:1153-1155. View abstract.
  690. Seugnet, L., Galvin, J. E., Suzuki, Y., Gottschalk, L., and Shaw, P. J. Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease. Sleep 8-1-2009;32:984-992. View abstract.
  691. Hutzen, B., Friedman, L., Sobo, M., Lin, L., Cen, L., De Angelis, S., Yamakoshi, H., Shibata, H., Iwabuchi, Y., and Lin, J. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas. Int.J Oncol. 2009;35:867-872. View abstract.
  692. Bill, M. A., Bakan, C., Benson, D. M., Jr., Fuchs, J., Young, G., and Lesinski, G. B. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol.Cancer Ther. 2009;8:2726-2735. View abstract.
  693. Lee, Y. K., Park, S. Y., Kim, Y. M., and Park, O. J. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. Ann.N.Y Acad.Sci. 2009;1171:489-494. View abstract.
  694. Reuter, S., Charlet, J., Juncker, T., Teiten, M. H., Dicato, M., and Diederich, M. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Ann.N.Y Acad.Sci. 2009;1171:436-447. View abstract.
  695. Clutterbuck, A. L., Mobasheri, A., Shakibaei, M., Allaway, D., and Harris, P. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann.N.Y Acad.Sci. 2009;1171:428-435. View abstract.
  696. Teiten, M. H., Eifes, S., Reuter, S., Duvoix, A., Dicato, M., and Diederich, M. Gene expression profiling related to anti-inflammatory properties of curcumin in K562 leukemia cells. Ann.N.Y Acad.Sci. 2009;1171:391-398. View abstract.
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  699. Matsunaga, T., Endo, S., Soda, M., Zhao, H. T., El Kabbani, O., Tajima, K., and Hara, A. Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem.Biophys.Res Commun. 11-6-2009;389:128-132. View abstract.
  700. Suda, T., Nagasawa, T., Wara-Aswapati, N., Kobayashi, H., Iwasaki, K., Yashiro, R., Hormdee, D., Nitta, H., Ishikawa, I., and Izumi, Y. Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells. Oral Microbiol.Immunol. 2009;24:384-389. View abstract.
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  704. Gowda, N. K., Ledoux, D. R., Rottinghaus, G. E., Bermudez, A. J., and Chen, Y. C. Antioxidant efficacy of curcuminoids from turmeric ( Curcuma longa L.) powder in broiler chickens fed diets containing aflatoxin B1. Br.J Nutr. 2009;102:1629-1634. View abstract.
  705. Graham, A. Curcumin adds spice to the debate: lipid metabolism in liver disease. Br.J Pharmacol 2009;157:1352-1353. View abstract.
  706. Watson, J. L., Greenshields, A., Hill, R., Hilchie, A., Lee, P. W., Giacomantonio, C. A., and Hoskin, D. W. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Mol.Carcinog. 2010;49:13-24. View abstract.
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  708. Kim, T., Davis, J., Zhang, A. J., He, X., and Mathews, S. T. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem.Biophys.Res Commun. 10-16-2009;388:377-382. View abstract.
  709. Rushworth, S. A. and Micheau, O. Molecular crosstalk between TRAIL and natural antioxidants in the treatment of cancer. Br.J Pharmacol 2009;157:1186-1188. View abstract.
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  713. Ray, B. and Lahiri, D. K. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr.Opin.Pharmacol 2009;9:434-444. View abstract.
  714. Girish, C., Koner, B. C., Jayanthi, S., Ramachandra, Rao K., Rajesh, B., and Pradhan, S. C. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam.Clin Pharmacol 2009;23:735-745. View abstract.
  715. Khafif, A., Lev-Ari, S., Vexler, A., Barnea, I., Starr, A., Karaush, V., Haif, S., and Ben Yosef, R. Curcumin: a potential radio-enhancer in head and neck cancer. Laryngoscope 2009;119:2019-2026. View abstract.
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  718. Seo, J. H., Jeong, K. J., Oh, W. J., Sul, H. J., Sohn, J. S., Kim, Y. K., Cho, do Y., Kang, J. K., Park, C. G., and Lee, H. Y. Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin. Cancer Lett. 2-1-2010;288:50-56. View abstract.
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  723. Carroll, C. E., Benakanakere, I., Besch-Williford, C., Ellersieck, M. R., and Hyder, S. M. Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors. Menopause. 2010;17:178-184. View abstract.
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  752. Shahiduzzaman, M., Dyachenko, V., Khalafalla, R. E., Desouky, A. Y., and Daugschies, A. Effects of curcumin on Cryptosporidium parvum in vitro. Parasitol.Res 2009;105:1155-1161. View abstract.
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  754. Mahfouz, M. M., Zhou, S. Q., and Kummerow, F. A. Curcumin prevents the oxidation and lipid modification of LDL and its inhibition of prostacyclin generation by endothelial cells in culture. Prostaglandins Other Lipid Mediat. 2009;90(1-2):13-20. View abstract.
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  756. Pan, C. J., Tang, J. J., Weng, Y. J., Wang, J., and Huang, N. Preparation and in vitro release profiles of drug-eluting controlled biodegradable polymer coating stents. Colloids Surf.B Biointerfaces. 10-15-2009;73:199-206. View abstract.
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  758. Sompamit, K., Kukongviriyapan, U., Nakmareong, S., Pannangpetch, P., and Kukongviriyapan, V. Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice. Eur.J Pharmacol 8-15-2009;616(1-3):192-199. View abstract.
  759. Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S., Gil, A., and Quiles, J. L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic.Biol.Med. 10-1-2009;47:924-931. View abstract.
  760. Xie, L., Li, X. K., Funeshima-Fuji, N., Kimura, H., Matsumoto, Y., Isaka, Y., and Takahara, S. Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production. Int.Immunopharmacol. 2009;9:575-581. View abstract.
  761. Katz, P. S., Trask, A. J., and Lucchesi, P. A. Curcuminoids: Spicing up sympathovagal tone. Nutrition 2009;25(7-8):879-880. View abstract.
  762. Smitha, S., Dhananjaya, B. L., Dinesha, R., and Srinivas, L. Purification and characterization of a approximately 34 kDa antioxidant protein (beta-turmerin) from turmeric (Curcuma longa) waste grits. Biochimie 2009;91:1156-1162. View abstract.
  763. Piantino, C. B., Salvadori, F. A., Ayres, P. P., Kato, R. B., Srougi, V., Leite, K. R., and Srougi, M. An evaluation of the anti-neoplastic activity of curcumin in prostate cancer cell lines. Int.Braz.J Urol. 2009;35:354-360. View abstract.
  764. Sampaio, F. J. Anti-neoplastic activity of curcumin in PCa. Int.Braz.J Urol. 2009;35:254-255. View abstract.
  765. Khan, M. S., Priyadarshini, M., and Bano, B. Preventive effect of curcumin and quercetin against nitric oxide mediated modification of goat lung cystatin. J Agric.Food Chem. 7-22-2009;57:6055-6059. View abstract.
  766. Shutava, T. G., Balkundi, S. S., Vangala, P., Steffan, J. J., Bigelow, R. L., Cardelli, J. A., O'Neal, D. P., and Lvov, Y. M. Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols. ACS Nano. 6-17-2009; View abstract.
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  768. Iranshahi, M., Sahebkar, A., Takasaki, M., Konoshima, T., and Tokuda, H. Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo. Eur.J Cancer Prev. 2009;18:412-415. View abstract.
  769. Kurien, B. T. Comment on Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric.Food Chem. 6-24-2009;57:5644-5646. View abstract.
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  771. Liu, Q., Loo, W. T., Sze, S. C., and Tong, Y. Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFkappaB, cyclinD and MMP-1 transcription. Phytomedicine. 2009;16:916-922. View abstract.
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  773. Binion, D. G., Heidemann, J., Li, M. S., Nelson, V. M., Otterson, M. F., and Rafiee, P. Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin. Am.J Physiol Gastrointest.Liver Physiol 2009;297:G259-G268. View abstract.
  774. Hanai, H. and Sugimoto, K. Curcumin has bright prospects for the treatment of inflammatory bowel disease. Curr.Pharm Des 2009;15:2087-2094. View abstract.
  775. Gupta, V., Aseh, A., Rios, C. N., Aggarwal, B. B., and Mathur, A. B. Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int.J Nanomedicine. 2009;4:115-122. View abstract.
  776. Ung, V. Y., Foshaug, R. R., MacFarlane, S. M., Churchill, T. A., Doyle, J. S., Sydora, B. C., and Fedorak, R. N. Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti-inflammatory effect in the IL-10 gene-deficient mouse model of IBD. Dig.Dis.Sci. 2010;55:1272-1277. View abstract.
  777. Lu, H. F., Lai, K. C., Hsu, S. C., Lin, H. J., Yang, M. D., Chen, Y. L., Fan, M. J., Yang, J. S., Cheng, P. Y., Kuo, C. L., and Chung, J. G. Curcumin induces apoptosis through FAS and FADD, in caspase-3-dependent and -independent pathways in the N18 mouse-rat hybrid retina ganglion cells. Oncol.Rep. 2009;22:97-104. View abstract.
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  779. Raghavendra, R. H. and Naidu, K. A. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot.Essent.Fatty Acids 2009;81:73-78. View abstract.
  780. Bisht, S. and Maitra, A. Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr.Drug Discov.Technol. 2009;6:192-199. View abstract.
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  782. Mohammadi, F., Bordbar, A. K., Divsalar, A., Mohammadi, K., and Saboury, A. A. Analysis of binding interaction of curcumin and diacetylcurcumin with human and bovine serum albumin using fluorescence and circular dichroism spectroscopy. Protein J 2009;28(3-4):189-196. View abstract.
  783. Yu, C. C., Hsu, M. J., Kuo, M. L., Chen, R. F., Chen, M. C., Bai, K. J., Yu, M. C., Chen, B. C., and Lin, C. H. Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway. J Immunol. 6-15-2009;182:7916-7927. View abstract.
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  791. Adaramoye, O. A., Anjos, R. M., Almeida, M. M., Veras, R. C., Silvia, D. F., Oliveira, F. A., Cavalcante, K. V., Araujo, I. G., Oliveira, A. P., and Medeiros, I. A. Hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from Curcuma longa L. in rats. J Ethnopharmacol. 7-30-2009;124:457-462. View abstract.
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  793. Rawal, R. C., Shah, B. J., Jayaraaman, A. M., and Jaiswal, V. Clinical evaluation of an Indian polyherbal topical formulation in the management of eczema. J Altern.Complement Med. 2009;15:669-672. View abstract.
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  796. Fang, X. D., Yang, F., Zhu, L., Shen, Y. L., Wang, L. L., and Chen, Y. Y. Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp.Pharmacol Physiol 2009;36:1177-1182. View abstract.
  797. Merrell, J. G., McLaughlin, S. W., Tie, L., Laurencin, C. T., Chen, A. F., and Nair, L. S. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp.Pharmacol Physiol 2009;36:1149-1156. View abstract.
  798. Sharma, M., Manoharlal, R., Shukla, S., Puri, N., Prasad, T., Ambudkar, S. V., and Prasad, R. Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Antimicrob.Agents Chemother. 2009;53:3256-3265. View abstract.
  799. Jang, J. Y., Lee, J. H., Jeong, S. Y., Chung, K. T., Choi, Y. H., and Choi, B. T. Partially purified Curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells. Exp.Dermatol. 2009;18:689-694. View abstract.
  800. Wang, J., Du, X. X., Jiang, H., and Xie, J. X. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochem.Pharmacol 7-15-2009;78:178-183. View abstract.
  801. Wang, S. L., Li, Y., Wen, Y., Chen, Y. F., Na, L. X., Li, S. T., and Sun, C. H. Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomed.Environ.Sci. 2009;22:32-39. View abstract.
  802. Deng, Y. T., Chen, H. M., Cheng, S. J., Chiang, C. P., and Kuo, M. Y. Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin. Oral Oncol. 2009;45:e99-e105. View abstract.
  803. Shin, H. W., Park, S. Y., Lee, K. B., and Jang, J. J. Down-regulation of Wnt signaling during apoptosis of human hepatic stellate cells. Hepatogastroenterology 2009;56:208-212. View abstract.
  804. Cai, X. Z., Wang, J., Li, X. D., Wang, G. L., Liu, F. N., Cheng, M. S., and Li, F. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. Cancer Biol.Ther. 2009;8:1360-1368. View abstract.
  805. Yu, Y. M. and Lin, H. C. Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression. Nutr.Metab Cardiovasc.Dis. 2010;20:125-132. View abstract.
  806. Yang, C., Zhang, X., Fan, H., and Liu, Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 7-28-2009;1282:133-141. View abstract.
  807. Cui, J., Meng, X., Gao, X., and Tan, G. Curcumin decreases the expression of Pokemon by suppressing the binding activity of the Sp1 protein in human lung cancer cells. Mol.Biol.Rep. 2010;37:1627-1632. View abstract.
  808. Mishra, R. K. and Singh, S. K. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception 2009;79:479-487. View abstract.
  809. Fryer, R. A., Galustian, C., and Dalgleish, A. G. Recent advances and developments in treatment strategies against pancreatic cancer. Curr.Clin Pharmacol 2009;4:102-112. View abstract.
  810. Dutta, K., Ghosh, D., and Basu, A. Curcumin protects neuronal cells from Japanese encephalitis virus-mediated cell death and also inhibits infective viral particle formation by dysregulation of ubiquitin-proteasome system. J Neuroimmune.Pharmacol 2009;4:328-337. View abstract.
  811. Masoumi, A., Goldenson, B., Ghirmai, S., Avagyan, H., Zaghi, J., Abel, K., Zheng, X., Espinosa-Jeffrey, A., Mahanian, M., Liu, P. T., Hewison, M., Mizwickie, M., Cashman, J., and Fiala, M. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2009;17:703-717. View abstract.
  812. Pae, H. O., Jeong, S. O., Zheng, M., Ha, H. Y., Lee, K. M., Kim, E. C., Kim, D. H., Hwang, S. Y., and Chung, H. T. Curcumin attenuates ethanol-induced toxicity in HT22 hippocampal cells by activating mitogen-activated protein kinase phosphatase-1. Neurosci.Lett. 4-10-2009;453:186-189. View abstract.
  813. Kita, T., Imai, S., Sawada, H., and Seto, H. Isolation of dihydrocurcuminoids from cell clumps and their distribution in various parts of turmeric (Curcuma longa). Biosci.Biotechnol.Biochem. 2009;73:1113-1117. View abstract.
  814. Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., Choi, H., Min, J. S., Kim, Y. S., Yoon, S. W., and Ahn, J. K. Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication. J Ethnopharmacol. 7-15-2009;124:189-196. View abstract.
  815. Kuo, C. T., Chen, B. C., Yu, C. C., Weng, C. M., Hsu, M. J., Chen, C. C., Chen, M. C., Teng, C. M., Pan, S. L., Bien, M. Y., Shih, C. H., and Lin, C. H. Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells. J Biomed.Sci. 2009;16:43. View abstract.
  816. Wichitnithad, W., Jongaroonngamsang, N., Pummangura, S., and Rojsitthisak, P. A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts. Phytochem.Anal. 2009;20:314-319. View abstract.
  817. Sahu, R. P., Batra, S., and Srivastava, S. K. Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells. Br.J Cancer 5-5-2009;100:1425-1433. View abstract.
  818. Pongchaidecha, A., Lailerd, N., Boonprasert, W., and Chattipakorn, N. Effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats. Nutrition 2009;25(7-8):870-878. View abstract.
  819. Zheng, Y. Y., Yu, L. S., Zhang, Y. G., Ye, G. H., and Yi, J. P. [Effects of curcumin on malondialdehyde and c-fos protein in hypoxia ischemia brain tissue in rats]. Fa.Yi.Xue.Za Zhi. 2009;25:6-8. View abstract.
  820. Chin, S. F., Iyer, K. S., Saunders, M., St Pierre, T. G., Buckley, C., Paskevicius, M., and Raston, C. L. Encapsulation and sustained release of curcumin using superparamagnetic silica reservoirs. Chemistry 6-2-2009;15:5661-5665. View abstract.
  821. Sharma, S., Zhuang, Y., Ying, Z., Wu, A., and Gomez-Pinilla, F. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience 7-21-2009;161:1037-1044. View abstract.
  822. Dong, Y., Liu, H. D., Zhao, R., Yang, C. Z., Chen, X. Q., Wang, X. H., Lau, L. T., Chen, J., and Yu, A. C. Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3gamma in astrocyte. J Neurochem. 2009;109 Suppl 1:182-188. View abstract.
  823. Mendonca, L. M., Dos Santos, G. C., Antonucci, G. A., Dos Santos, A. C., Bianchi, Mde L., and Antunes, L. M. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat.Res 4-30-2009;675(1-2):29-34. View abstract.
  824. Friedman, L., Lin, L., Ball, S., Bekaii-Saab, T., Fuchs, J., Li, P. K., Li, C., and Lin, J. Curcumin analogues exhibit enhanced growth suppressive activity in human pancreatic cancer cells. Anticancer Drugs 2009;20:444-449. View abstract.
  825. Gautam, R. and Jachak, S. M. Recent developments in anti-inflammatory natural products. Med.Res Rev. 2009;29:767-820. View abstract.
  826. Sethi, P., Jyoti, A., Hussain, E., and Sharma, D. Curcumin attenuates aluminium-induced functional neurotoxicity in rats. Pharmacol Biochem.Behav. 2009;93:31-39. View abstract.
  827. Jancinova, V., Perecko, T., Nosal, R., Kostalova, D., Bauerova, K., and Drabikova, K. Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition. Eur.J Pharmacol 6-10-2009;612(1-3):161-166. View abstract.
  828. Srinivas, L. and Shalini, V. K. DNA damage by smoke: protection by turmeric and other inhibitors of ROS. Free Radic.Biol.Med 1991;11:277-283. View abstract.
  829. Purkayastha, S., Berliner, A., Fernando, S. S., Ranasinghe, B., Ray, I., Tariq, H., and Banerjee, P. Curcumin Blocks Brain Tumor Formation. Brain Res 2-10-2009; View abstract.
  830. Hegde, M. L., Bharathi, P., Suram, A., Venugopal, C., Jagannathan, R., Poddar, P., Srinivas, P., Sambamurti, K., Rao, K. J., Scancar, J., Messori, L., Zecca, L., and Zatta, P. Challenges associated with metal chelation therapy in Alzheimer's disease. J Alzheimers.Dis. 2009;17:457-468. View abstract.
  831. Dance-Barnes, S. T., Kock, N. D., Moore, J. E., Lin, E. Y., Mosley, L. J., D'Agostino, R. B., Jr., McCoy, T. P., Townsend, A. J., and Miller, M. S. Lung tumor promotion by curcumin. Carcinogenesis 2009;30:1016-1023. View abstract.
  832. Herebian, D., Choi, J. H., Abd El-Aty, A. M., Shim, J. H., and Spiteller, M. Metabolite analysis in Curcuma domestica using various GC-MS and LC-MS separation and detection techniques. Biomed.Chromatogr. 2009;23:951-965. View abstract.
  833. Sanderson, R. O., Beata, C., Flipo, R. M., Genevois, J. P., Macias, C., Tacke, S., Vezzoni, A., and Innes, J. F. Systematic review of the management of canine osteoarthritis. Vet.Rec. 4-4-2009;164:418-424. View abstract.
  834. Cekmen, M., Ilbey, Y. O., Ozbek, E., Simsek, A., Somay, A., and Ersoz, C. Curcumin prevents oxidative renal damage induced by acetaminophen in rats. Food Chem.Toxicol 2009;47:1480-1484. View abstract.
  835. Tang, H., Lu, D., Pan, R., Qin, X., Xiong, H., and Dong, J. Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sci. 7-3-2009;85(1-2):1-10. View abstract.
  836. Bas, M., Tugcu, V., Kemahli, E., Ozbek, E., Uhri, M., Altug, T., and Tasci, A. I. Curcumin prevents shock-wave lithotripsy-induced renal injury through inhibition of nuclear factor kappa-B and inducible nitric oxide synthase activity in rats. Urol.Res 2009;37:159-164. View abstract.
  837. Chaturvedi, T. P. Uses of turmeric in dentistry: an update. Indian J Dent.Res 2009;20:107-109. View abstract.
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  839. Ji, H. F. and Shen, L. Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism. Bioorg.Med.Chem.Lett. 5-1-2009;19:2453-2455. View abstract.
  840. Ishrat, T., Hoda, M. N., Khan, M. B., Yousuf, S., Ahmad, M., Khan, M. M., Ahmad, A., and Islam, F. Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT). Eur.Neuropsychopharmacol. 2009;19:636-647. View abstract.
  841. Avagyan, H., Goldenson, B., Tse, E., Masoumi, A., Porter, V., Wiedau-Pazos, M., Sayre, J., Ong, R., Mahanian, M., Koo, P., Bae, S., Micic, M., Liu, P. T., Rosenthal, M. J., and Fiala, M. Immune blood biomarkers of Alzheimer disease patients. J.Neuroimmunol. 5-29-2009;210(1-2):67-72. View abstract.
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  843. Kim, W., Fan, Y. Y., Smith, R., Patil, B., Jayaprakasha, G. K., McMurray, D. N., and Chapkin, R. S. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. J Nutr. 2009;139:1042-1048. View abstract.
  844. Seehofer, D., Schirmeier, A., Bengmark, S., Cho, S. Y., Koch, M., Lederer, A., Rayes, N., Menger, M. D., Neuhaus, P., and Nussler, A. K. Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy with simultaneous intraabdominal infection in rats. J Surg.Res 2010;159:497-502. View abstract.
  845. Leung, M. H. and Kee, T. W. Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Langmuir 5-19-2009;25:5773-5777. View abstract.
  846. Ali, M. S., Mudagal, M. P., and Goli, D. Cardioprotective effect of tetrahydrocurcumin and rutin on lipid peroxides and antioxidants in experimentally induced myocardial infarction in rats. Pharmazie 2009;64:132-136. View abstract.
  847. Lam, J. B., Chow, K. H., Xu, A., Lam, K. S., Liu, J., Wong, N. S., Moon, R. T., Shepherd, P. R., Cooper, G. J., and Wang, Y. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. PLoS.One. 2009;4:e4968. View abstract.
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  850. Decote-Ricardo, D., Chagas, K. K., Rocha, J. D., Redner, P., Lopes, U. G., Cambier, J. C., Barros, de Arruda, and Pecanha, L. M. Modulation of in vitro murine B-lymphocyte response by curcumin. Phytomedicine. 2009;16:982-988. View abstract.
  851. Li, Y. C., Wang, F. M., Pan, Y., Qiang, L. Q., Cheng, G., Zhang, W. Y., and Kong, L. D. Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog.Neuropsychopharmacol.Biol.Psychiatry 4-30-2009;33:435-449. View abstract.
  852. Tang, Y., Zheng, S., and Chen, A. Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 2009;150:3011-3020. View abstract.
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  854. Wang, J. B., Qi, L. L., Zheng, S. D., Wang, H. Z., and Wu, T. X. Curcumin suppresses PPARdelta expression and related genes in HT-29 cells. World J Gastroenterol. 3-21-2009;15:1346-1352. View abstract.
  855. Heo, H. J., Lee, S. Y., Lee, M. N., Lee, H. J., Seok, J. H., and Lee, C. J. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother.Res 2009;23:1458-1461. View abstract.
  856. Chiu, T. L. and Su, C. C. Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells. Int.J Mol.Med. 2009;23:469-475. View abstract.
  857. Arafa, H. M., Hemeida, R. A., El Bahrawy, A. I., and Hamada, F. M. Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model. Food Chem.Toxicol 2009;47:1311-1317. View abstract.
  858. Cheng, S. E., Luo, S. F., Jou, M. J., Lin, C. C., Kou, Y. R., Lee, I. T., Hsieh, H. L., and Yang, C. M. Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells. Free Radic.Biol.Med. 4-1-2009;46:948-960. View abstract.
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  861. Garai, J. and Lorand, T. Macrophage migration inhibitory factor (MIF) tautomerase inhibitors as potential novel anti-inflammatory agents: current developments. Curr.Med.Chem. 2009;16:1091-1114. View abstract.
  862. Rezende, L. F., Vieira, A. S., Negro, A., Langone, F., and Boschero, A. C. Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis. Cytokine 2009;46:65-71. View abstract.
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  865. Chen, Q., Lu, G., Wang, Y., Xu, Y., Zheng, Y., Yan, L., Jiang, Z., Yang, L., Zhan, J., Wu, Y., and Zhou, J. Cytoskeleton disorganization during apoptosis induced by curcumin in A549 lung adenocarcinoma cells. Planta Med. 2009;75:808-813. View abstract.
  866. Capini, C., Jaturanpinyo, M., Chang, H. I., Mutalik, S., McNally, A., Street, S., Steptoe, R., O'Sullivan, B., Davies, N., and Thomas, R. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol. 3-15-2009;182:3556-3565. View abstract.
  867. Lu, H. F., Yang, J. S., Lai, K. C., Hsu, S. C., Hsueh, S. C., Chen, Y. L., Chiang, J. H., Lu, C. C., Lo, C., Yang, M. D., and Chung, J. G. Curcumin-induced DNA damage and inhibited DNA repair genes expressions in mouse-rat hybrid retina ganglion cells (N18). Neurochem.Res 2009;34:1491-1497. View abstract.
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  869. Barry, J., Fritz, M., Brender, J. R., Smith, P. E., Lee, D. K., and Ramamoorthy, A. Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin. J Am.Chem.Soc. 4-1-2009;131:4490-4498. View abstract.
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  871. Labbozzetta, M., Notarbartolo, M., Poma, P., Maurici, A., Inguglia, L., Marchetti, P., Rizzi, M., Baruchello, R., Simoni, D., and D'Alessandro, N. Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer. Ann.N.Y Acad.Sci. 2009;1155:278-283. View abstract.
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  875. Half, E. and Arber, N. Colon cancer: preventive agents and the present status of chemoprevention. Expert.Opin.Pharmacother. 2009;10:211-219. View abstract.
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  877. Isik, A. T., Celik, T., Ulusoy, G., Ongoru, O., Elibol, B., Doruk, H., Bozoglu, E., Kayir, H., Mas, M. R., and Akman, S. Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model. Age (Dordr.) 2009;31:39-49. View abstract.
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  880. Gouda, E. M., Elbehairy, A. M., and Ghoneim, M. A. Antimutagenic efficacy of some natural compounds on cyclophosphamide-induced p53 alterations. Z.Naturforsch.C. 2008;63(11-12):857-863. View abstract.
  881. Harikumar, K. B., Kuttan, G., and Kuttan, R. Inhibition of progression of erythroleukemia induced by Friend virus in BALB/c mice by natural products--berberine, curcumin and picroliv. J Exp.Ther.Oncol. 2008;7:275-284. View abstract.
  882. Ghosh, S. S., Massey, H. D., Krieg, R., Fazelbhoy, Z. A., Ghosh, S., Sica, D. A., Fakhry, I., and Gehr, T. W. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation. Am.J Physiol Renal Physiol 2009;296:F1146-F1157. View abstract.
  883. Hu, J., Wang, Y., and Chen, Y. Curcumin-induced histone acetylation in malignant hematologic cells. J Huazhong.Univ Sci.Technolog.Med.Sci. 2009;29:25-28. View abstract.
  884. Yadav, V. R., Suresh, S., Devi, K., and Yadav, S. Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease. J Pharm Pharmacol 2009;61:311-321. View abstract.
  885. Cohen, A. N., Veena, M. S., Srivatsan, E. S., and Wang, M. B. Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase. Arch.Otolaryngol.Head Neck Surg. 2009;135:190-197. View abstract.
  886. Mishra, K., Dash, A. P., Swain, B. K., and Dey, N. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar.J 2009;8:26. View abstract.
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  888. Al Zanbagi, N. A. and Zelai, N. T. Two methods for attenuating Toxoplasma gondii tachyzoites RH strain by using ethanol extract of Curcuma longa. J Egypt Soc.Parasitol. 2008;38:965-976. View abstract.
  889. De, R., Kundu, P., Swarnakar, S., Ramamurthy, T., Chowdhury, A., Nair, G. B., and Mukhopadhyay, A. K. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob.Agents Chemother. 2009;53:1592-1597. View abstract.
  890. Kim, Y., Lee, J. H., Ryu, J., and Kim, D. J. Multivalent & multifunctional ligands to beta-amyloid. Curr.Pharm Des 2009;15:637-658. View abstract.
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  902. Lavoie, S., Chen, Y., Dalton, T. P., Gysin, R., Cuenod, M., Steullet, P., and Do, K. Q. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J Neurochem. 2009;108:1410-1422. View abstract.
  903. Huang, A. C., Lin, S. Y., Su, C. C., Lin, S. S., Ho, C. C., Hsia, T. C., Chiu, T. H., Yu, C. S., Ip, S. W., Lin, T. P., and Chung, J. G. Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo. In Vivo 2008;22:781-785. View abstract.
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  906. Zhou, H., Li, X., and Gao, M. Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. Basic Clin Pharmacol Toxicol 2009;104:236-240. View abstract.
  907. Subudhi, U., Das, K., Paital, B., Bhanja, S., and Chainy, G. B. Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats. Life Sci. 3-13-2009;84(11-12):372-379. View abstract.
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  910. Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Odajima, N., Moriyama, C., Nasuhara, Y., and Nishimura, M. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am.J Physiol Lung Cell Mol.Physiol 2009;296:L614-L623. View abstract.
  911. Iqbal, M., Okazaki, Y., and Okada, S. Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention. Mol.Cell Biochem. 2009;324(1-2):157-164. View abstract.
  912. Conboy, L., Foley, A. G., O'Boyle, N. M., Lawlor, M., Gallagher, H. C., Murphy, K. J., and Regan, C. M. Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats. Biochem.Pharmacol 4-1-2009;77:1254-1265. View abstract.
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  927. Mandal, M. N., Patlolla, J. M., Zheng, L., Agbaga, M. P., Tran, J. T., Wicker, L., Kasus-Jacobi, A., Elliott, M. H., Rao, C. V., and Anderson, R. E. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic.Biol.Med. 3-1-2009;46:672-679. View abstract.
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  932. Jyoti, A., Sethi, P., and Sharma, D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav. 2009;14:300-308. View abstract.
  933. Magalhaes, L. G., Machado, C. B., Morais, E. R., Moreira, E. B., Soares, C. S., da Silva, S. H., Silva Filho, A. A., and Rodrigues, V. In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. Parasitol.Res 2009;104:1197-1201. View abstract.
  934. Di Giorgio, A. M., Hou, Y., Zhao, X., Zhang, B., Lyeth, B. G., and Russell, M. J. Dimethyl sulfoxide provides neuroprotection in a traumatic brain injury model. Restor.Neurol.Neurosci. 2008;26:501-507. View abstract.
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  941. Li, X., Hu, Y. B., and Peng, J. W. [Silicon dioxide-upregulated plasminogen activators inhibitor-1 protein expression is dependent on activation of extracellular signal-regulated kinase/activator protein-1 signaling pathway]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:387-390. View abstract.
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  944. Ono, K., Hirohata, M., and Yamada, M. Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders. Curr.Pharm Des 2008;14:3247-3266. View abstract.
  945. Rafiee, P., Nelson, V. M., Manley, S., Wellner, M., Floer, M., Binion, D. G., and Shaker, R. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. Am.J Physiol Gastrointest.Liver Physiol 2009;296:G388-G398. View abstract.
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  954. Madden, K., Flowers, L., Salani, R., Horowitz, I., Logan, S., Kowalski, K., Xie, J., and Mohammed, S. I. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. Prostaglandins Leukot.Essent.Fatty Acids 2009;80:9-18. View abstract.
  955. William, B. M., Goodrich, A., Peng, C., and Li, S. Curcumin inhibits proliferation and induces apoptosis of leukemic cells expressing wild-type or T315I-BCR-ABL and prolongs survival of mice with acute lymphoblastic leukemia. Hematology. 2008;13:333-343. View abstract.
  956. Uddin, S., Khan, A. S., and Al Kuraya, K. S. Developing curcumin into a viable therapeutic for lymphoma. Expert.Opin.Investig.Drugs 2009;18:57-67. View abstract.
  957. Verma, R. J., Chakraborty, B. S., Patel, C., and Mathuria, N. Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice. Acta Pol.Pharm 2008;65:415-419. View abstract.
  958. El Demerdash, F. M., Yousef, M. I., and Radwan, F. M. Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs. Food Chem.Toxicol 2009;47:249-254. View abstract.
  959. Girish, C. and Pradhan, S. C. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin. Fundam.Clin Pharmacol 2008;22:623-632. View abstract.
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  961. Martins, C. V., da Silva, D. L., Neres, A. T., Magalhaes, T. F., Watanabe, G. A., Modolo, L. V., Sabino, A. A., de Fatima, A., and de Resende, M. A. Curcumin as a promising antifungal of clinical interest. J Antimicrob.Chemother. 2009;63:337-339. View abstract.
  962. Dujic, J., Kippenberger, S., Ramirez-Bosca, A., Diaz-Alperi, J., Bereiter-Hahn, J., Kaufmann, R., Bernd, A., and Hofmann, M. Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model. Int.J Cancer 3-15-2009;124:1422-1428. View abstract.
  963. Krasovsky, J., Chang, D. H., Deng, G., Yeung, S., Lee, M., Leung, P. C., Cunningham-Rundles, S., Cassileth, B., and Dhodapkar, M. V. Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa). Planta Med. 2009;75:312-315. View abstract.
  964. Shimouchi, A., Nose, K., Takaoka, M., Hayashi, H., and Kondo, T. Effect of dietary turmeric on breath hydrogen. Dig.Dis.Sci. 2009;54:1725-1729. View abstract.
  965. Rastogi, M., Ojha, R. P., Rajamanickam, G. V., Agrawal, A., Aggarwal, A., and Dubey, G. P. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. Free Radic.Res 2008;42(11-12):999-1005. View abstract.
  966. Sharma, D., Sethi, P., Hussain, E., and Singh, R. Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions. Biogerontology. 2009;10:489-502. View abstract.
  967. Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., and Wan, Y. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol.Rep. 2008;20:1553-1559. View abstract.
  968. Choi, H., Chun, Y. S., Shin, Y. J., Ye, S. K., Kim, M. S., and Park, J. W. Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT. Cancer Sci. 2008;99:2518-2524. View abstract.
  969. Cao, J., Liu, Y., Jia, L., Jiang, L. P., Geng, C. Y., Yao, X. F., Kong, Y., Jiang, B. N., and Zhong, L. F. Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric.Food Chem. 12-24-2008;56:12059-12063. View abstract.
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  971. Guzel, A., Kanter, M., Aksu, B., Basaran, U. N., Yalcin, O., Guzel, A., Uzun, H., Konukoglu, D., and Karasalihoglu, S. Preventive effects of curcumin on different aspiration material-induced lung injury in rats. Pediatr.Surg.Int. 2009;25:83-92. View abstract.
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  973. Ryu, M. J., Cho, M., Song, J. Y., Yun, Y. S., Choi, I. W., Kim, D. E., Park, B. S., and Oh, S. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem.Biophys.Res Commun. 12-26-2008;377:1304-1308. View abstract.
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  975. Cutler, W. B. Re: Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cell. Menopause. 2008;15:1195. View abstract.
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  977. Agrawal, D. K., Saikia, D., Tiwari, R., Ojha, S., Shanker, K., Kumar, J. K., Gupta, A. K., Tandon, S., Negi, A. S., and Khanuja, S. P. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008;74:1828-1831. View abstract.
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  982. Jain, S. K., Rains, J., Croad, J., Larson, B., and Jones, K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid.Redox.Signal. 2009;11:241-249. View abstract.
  983. Chang, L. Y., Wan, H. C., Lai, Y. L., Kuo, Y. F., Liu, T. Y., Chen, Y. T., and Hung, S. L. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. J Periodontal Res 2009;44:175-183. View abstract.
  984. Liu, Y., Yang, Z., Du, J., Yao, X., Lei, R., Zheng, X., Liu, J., Hu, H., and Li, H. Interaction of curcumin with intravenous immunoglobulin: a fluorescence quenching and Fourier transformation infrared spectroscopy study. Immunobiology 2008;213:651-661. View abstract.
  985. Nanditha, B. and Prabhasankar, P. Antioxidants in bakery products: a review. Crit Rev.Food Sci.Nutr. 2009;49:1-27. View abstract.
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  989. Ahmed, T. and Gilani, A. H. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem.Behav. 2009;91:554-559. View abstract.
  990. Hussain, A. R., Ahmed, M., Al Jomah, N. A., Khan, A. S., Manogaran, P., Sultana, M., Abubaker, J., Platanias, L. C., Al Kuraya, K. S., and Uddin, S. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol.Cancer Ther. 2008;7:3318-3329. View abstract.
  991. Youn, Y. N., Lim, E., Lee, N., Kim, Y. S., Koo, M. S., and Choi, S. Y. Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro. Genes Nutr. 2008;2:375-380. View abstract.
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  994. Shukla, S., Zaher, H., Hartz, A., Bauer, B., Ware, J. A., and Ambudkar, S. V. Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res 2009;26:480-487. View abstract.
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  996. Zhang, L. J., Wu, C. F., Meng, X. L., Yuan, D., Cai, X. D., Wang, Q. L., and Yang, J. Y. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neurosci.Lett. 12-5-2008;447:48-53. View abstract.
  997. Zhao, C. J., Niu, J. Z., Wang, J. F., Zhou, G., and Tang, B. H. [Effects of curcumin on bleomycin-induced damages in pulmonary functions in rats]. Zhongguo Zhong.Yao Za Zhi. 2008;33:1434-1438. View abstract.
  998. Wan, R., Mo, Y., Zhang, X., Chien, S., Tollerud, D. J., and Zhang, Q. Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tyrosine kinase activation. Toxicol Appl.Pharmacol 12-1-2008;233:276-285. View abstract.
  999. Sa, G. and Das, T. Anti cancer effects of curcumin: cycle of life and death. Cell Div. 2008;3:14. View abstract.
  1000. Lubbad, A. S., Oriowo, M. A., and Khan, I. Curcumin reverses attenuated carbachol-induced contraction of the colon in a rat model of colitis. Scand.J Gastroenterol. 2009;44:187-194. View abstract.
  1001. Wang, D., Veena, M. S., Stevenson, K., Tang, C., Ho, B., Suh, J. D., Duarte, V. M., Faull, K. F., Mehta, K., Srivatsan, E. S., and Wang, M. B. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res 10-1-2008;14:6228-6236. View abstract.
  1002. Dohare, P., Garg, P., Sharma, U., Jagannathan, N. R., and Ray, M. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC.Complement Altern.Med. 2008;8:55. View abstract.
  1003. Inoue, K., Nomura, C., Ito, S., Nagatsu, A., Hino, T., and Oka, H. Purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography. J Agric.Food Chem. 10-22-2008;56:9328-9336. View abstract.
  1004. Wang, L. Y., Zhang, M., Zhang, C. F., and Wang, Z. T. Alkaloid and sesquiterpenes from the root tuber of Curcuma longa. Yao Xue.Xue.Bao. 2008;43:724-727. View abstract.
  1005. Larmonier, C. B., Uno, J. K., Lee, K. M., Karrasch, T., Laubitz, D., Thurston, R., Midura-Kiela, M. T., Ghishan, F. K., Sartor, R. B., Jobin, C., and Kiela, P. R. Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection. Am.J Physiol Gastrointest.Liver Physiol 2008;295:G1079-G1091. View abstract.
  1006. Barnes, P. J. Role of HDAC2 in the pathophysiology of COPD. Annu.Rev.Physiol 2009;71:451-464. View abstract.
  1007. Tajik, H., Tamaddonfard, E., and Hamzeh-Gooshchi, N. The effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats. Pak.J Biol.Sci. 1-15-2008;11:312-314. View abstract.
  1008. Liu, X., Togo, S., Al Mugotir, M., Kim, H., Fang, Q., Kobayashi, T., Wang, X., Mao, L., Bitterman, P., and Rennard, S. NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract. Respir.Res 2008;9:66. View abstract.
  1009. Moosajee, M., Gregory-Evans, K., Ellis, C. D., Seabra, M. C., and Gregory-Evans, C. Y. Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. Hum.Mol.Genet. 12-15-2008;17:3987-4000. View abstract.
  1010. Kapoor, P., Ansari, M. N., and Bhandari, U. Modulatory effect of curcumin on methionine-induced hyperlipidemia and hyperhomocysteinemia in albino rats. Indian J Exp.Biol. 2008;46:534-540. View abstract.
  1011. Sun, J., Yang, D., Li, S., Xu, Z., Wang, X., and Bai, C. Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats. Eur.Respir.J 2009;33:398-404. View abstract.
  1012. Tharappel, J. C., Lehmler, H. J., Srinivasan, C., Robertson, L. W., Spear, B. T., and Glauert, H. P. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem.Toxicol 2008;46:3467-3474. View abstract.
  1013. Adapala, N. and Chan, M. M. Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model. Lab Invest 2008;88:1329-1339. View abstract.
  1014. Chen, H. W., Lee, J. Y., Huang, J. Y., Wang, C. C., Chen, W. J., Su, S. F., Huang, C. W., Ho, C. C., Chen, J. J., Tsai, M. F., Yu, S. L., and Yang, P. C. Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 9-15-2008;68:7428-7438. View abstract.
  1015. Milacic, V., Banerjee, S., Landis-Piwowar, K. R., Sarkar, F. H., Majumdar, A. P., and Dou, Q. P. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res 9-15-2008;68:7283-7292. View abstract.
  1016. Ren, L., Wang, J., Tang, J., Pan, C., and Huang, N. [Influence of curcumin--loaded poly (lactide-co-glycolide) films on the proliferation of vascular smooth muscle cells]. Sheng Wu Yi.Xue.Gong.Cheng Xue.Za Zhi. 2008;25:874-878. View abstract.
  1017. Yu, S., Shen, G., Khor, T. O., Kim, J. H., and Kong, A. N. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol.Cancer Ther. 2008;7:2609-2620. View abstract.
  1018. Sahu, A., Kasoju, N., and Bora, U. Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules. 2008;9:2905-2912. View abstract.
  1019. Patel, N. A., Patel, N. J., and Patel, R. P. Design and evaluation of transdermal drug delivery system for curcumin as an anti-inflammatory drug. Drug Dev.Ind.Pharm 2009;35:234-242. View abstract.
  1020. Kelley, B. J. and Knopman, D. S. Alternative medicine and Alzheimer disease. Neurologist. 2008;14:299-306. View abstract.
  1021. Anand, P., Thomas, S. G., Kunnumakkara, A. B., Sundaram, C., Harikumar, K. B., Sung, B., Tharakan, S. T., Misra, K., Priyadarsini, I. K., Rajasekharan, K. N., and Aggarwal, B. B. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem.Pharmacol 12-1-2008;76:1590-1611. View abstract.
  1022. Hegge, A. B., Schuller, R. B., Kristensen, S., and Tonnesen, H. H. In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII. Pharmazie 2008;63:585-592. View abstract.
  1023. Aggarwal, B. B. Prostate cancer and curcumin: add spice to your life. Cancer Biol.Ther. 2008;7:1436-1440. View abstract.
  1024. Tanaka, K., Kuba, Y., Sasaki, T., Hiwatashi, F., and Komatsu, K. Quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis. J Agric.Food Chem. 10-8-2008;56:8787-8792. View abstract.
  1025. von, Metzler, I, Krebbel, H., Kuckelkorn, U., Heider, U., Jakob, C., Kaiser, M., Fleissner, C., Terpos, E., and Sezer, O. Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase. J Cancer Res Clin Oncol. 2009;135:173-179. View abstract.
  1026. Kulkarni, S. K., Bhutani, M. K., and Bishnoi, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl) 2008;201:435-442. View abstract.
  1027. Thayyullathil, F., Chathoth, S., Hago, A., Patel, M., and Galadari, S. Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. Free Radic.Biol.Med. 11-15-2008;45:1403-1412. View abstract.
  1028. Reuter, S., Eifes, S., Dicato, M., Aggarwal, B. B., and Diederich, M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem.Pharmacol 12-1-2008;76:1340-1351. View abstract.
  1029. Memis, D., Hekimoglu, S., Sezer, A., Altaner, S., Sut, N., and Usta, U. Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat. Nutrition 2008;24(11-12):1133-1138. View abstract.
  1030. Wakade, C., King, M. D., Laird, M. D., Alleyne, C. H., Jr., and Dhandapani, K. M. Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice. Antioxid.Redox.Signal. 2009;11:35-45. View abstract.
  1031. Chen, B., Zhang, D. P., and Gao, W. [Effect of curcumin on the expression of collagen type I protein and transforming growth factor-beta1mRNA in pulmonary fibrosis rats]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:257-261. View abstract.
  1032. Sahoo, D. K., Roy, A., and Chainy, G. B. Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chem.Biol.Interact. 11-25-2008;176(2-3):121-128. View abstract.
  1033. Zhang, J. S., Guan, J., Yang, F. Q., Liu, H. G., Cheng, X. J., and Li, S. P. Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. J Pharm Biomed.Anal. 11-4-2008;48:1024-1028. View abstract.
  1034. Adhvaryu, M. R., Reddy, N., and Vakharia, B. C. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 8-14-2008;14:4753-4762. View abstract.
  1035. Foller, M., Huber, S. M., and Lang, F. Erythrocyte programmed cell death. IUBMB.Life 2008;60:661-668. View abstract.
  1036. Dempe, J. S., Pfeiffer, E., Grimm, A. S., and Metzler, M. Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells. Mol.Nutr.Food Res 2008;52:1074-1081. View abstract.
  1037. Thangapazham, R. L., Shaheduzzaman, S., Kim, K. H., Passi, N., Tadese, A., Vahey, M., Dobi, A., Srivastava, S., and Maheshwari, R. K. Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome. Cancer Biol.Ther. 2008;7:1427-1435. View abstract.
  1038. Oh, S., Kyung, T. W., and Choi, H. S. Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Mol.Cells 11-30-2008;26:486-489. View abstract.
  1039. Ghoneim, A. I. Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c. Naunyn Schmiedebergs Arch.Pharmacol 2009;379:47-60. View abstract.
  1040. Veillat, V., Lavoie, C. H., Metz, C. N., Roger, T., Labelle, Y., and Akoum, A. Involvement of nuclear factor-kappaB in macrophage migration inhibitory factor gene transcription up-regulation induced by interleukin- 1 beta in ectopic endometrial cells. Fertil.Steril. 2009;91(5 Suppl):2148-2156. View abstract.
  1041. Moon, D. O., Kim, M. O., Lee, H. J., Choi, Y. H., Park, Y. M., Heo, M. S., and Kim, G. Y. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem.Biophys.Res Commun. 10-17-2008;375:275-279. View abstract.
  1042. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam.Clin Pharmacol 2008;22:417-427. View abstract.
  1043. Dou, X., Fan, C., Wo, L., Yan, J., Qian, Y., and Wo, X. Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med. 2008;74:1374-1379. View abstract.
  1044. Shen, F., Fan, X., Liu, B., Jia, X., Gao, A., Du, H., Ye, M., You, B., Huang, C., and Shi, X. Downregulation of cyclin D1-CDK4 protein in human embryonic lung fibroblasts (HELF) induced by silica is mediated through the ERK and JNK pathway. Cell Biol.Int. 2008;32:1284-1292. View abstract.
  1045. Lin, S. S., Huang, H. P., Yang, J. S., Wu, J. Y., Hsia, T. C., Lin, C. C., Lin, C. W., Kuo, C. L., Gibson, Wood W., and Chung, J. G. DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. Cancer Lett. 12-8-2008;272:77-90. View abstract.
  1046. Pan, R., Qiu, S., Lu, D. X., and Dong, J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med.J (Engl) 5-5-2008;121:832-839. View abstract.
  1047. Illouz, S., Alexandre, E., Pattenden, C., Mark, L., Bachellier, P., Webb, M., Berry, D., Dennison, A., and Richert, L. Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. Phytother.Res 2008;22:1688-1691. View abstract.
  1048. Kanitkar, M., Gokhale, K., Galande, S., and Bhonde, R. R. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br.J Pharmacol 2008;155:702-713. View abstract.
  1049. Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., and Sugimoto, H. Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport 8-27-2008;19:1329-1333. View abstract.
  1050. Garg, R., Ingle, A., and Maru, G. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-kappaB pathway to alter cellular responses during hamster buccal pouch carcinogenesis. Toxicol Appl.Pharmacol 11-1-2008;232:428-439. View abstract.
  1051. Eybl, V., Kotyzova, D., Cerna, P., and Koutensky, J. Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats. Hum.Exp.Toxicol 2008;27:347-353. View abstract.
  1052. Wang, W. X., Sun, S. Z., Guo, X. L., and Song, Y. [Effect of curcumin on invasion and migration of tongue squamous cell carcinoma cell line Tca8113]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 2008;43:101-104. View abstract.
  1053. Sotanaphun, U., Phattanawasin, P., and Sriphong, L. Application of Scion image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa). Phytochem.Anal. 2009;20:19-23. View abstract.
  1054. Tsui, K. H., Feng, T. H., Lin, C. M., Chang, P. L., and Juang, H. H. Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells. J Androl 2008;29:661-668. View abstract.
  1055. Davis, C. D. and Ross, S. A. Evidence for dietary regulation of microRNA expression in cancer cells. Nutr.Rev. 2008;66:477-482. View abstract.
  1056. Aggarwal, B. B. and Harikumar, K. B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int.J Biochem.Cell Biol. 2009;41:40-59. View abstract.
  1057. Zhang, X. G., Wang, D. M., and Huang, Q. [Study on extracting process for Tiao ZhiAn mixture]. Zhong.Yao Cai. 2008;31:594-597. View abstract.
  1058. Han, G., Bi, R., Le, Q., Zhao, L. L., Dong, Y., and Lin, Q. H. [Study on effect of demethoxycurcumin in Curcuma long on stability of curcumin]. Zhong.Yao Cai. 2008;31:592-594. View abstract.
  1059. Wang, H. H., Hsieh, H. L., Wu, C. Y., Sun, C. C., and Yang, C. M. Oxidized low-density lipoprotein induces matrix metalloproteinase-9 expression via a p42/p44 and JNK-dependent AP-1 pathway in brain astrocytes. Glia 1-1-2009;57:24-38. View abstract.
  1060. Bharal, N., Sahaya, K., Jain, S., Mediratta, P. K., and Sharma, K. K. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother.Res 2008;22:1660-1664. View abstract.
  1061. Sameermahmood, Z., Balasubramanyam, M., Saravanan, T., and Rema, M. Curcumin modulates SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells (HRECs). Invest Ophthalmol.Vis.Sci. 2008;49:3305-3311. View abstract.
  1062. Villegas, I., Sanchez-Fidalgo, S., and Alarcon, de la Lastra. New mechanisms and therapeutic potential of curcumin for colorectal cancer. Mol.Nutr.Food Res 2008;52:1040-1061. View abstract.
  1063. Mattson, M. P., Son, T. G., and Camandola, S. Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose.Response 2007;5:174-186. View abstract.
  1064. Mathuria, N. and Verma, R. J. Ameliorative effect of curcumin on aflatoxin-induced toxicity in serum of mice. Acta Pol.Pharm 2008;65:339-343. View abstract.
  1065. Ye, M., Liu, B., Jia, X., and Gao, A. [Overexpression and higher phosphorylation of p53 induced by benzo(a) pyrene through activated protein 1 independent pathway]. Wei Sheng Yan.Jiu. 2008;37:255-258. View abstract.
  1066. Sarada, S., Himadri, P., Mishra, C., Geetali, P., Ram, M. S., and Ilavazhagan, G. Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema. Exp.Biol.Med.(Maywood.) 2008;233:1088-1098. View abstract.
  1067. Zhao, J., Zhao, Y., Zheng, W., Lu, Y., Feng, G., and Yu, S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 9-10-2008;1229:224-232. View abstract.
  1068. Shirley, S. A., Montpetit, A. J., Lockey, R. F., and Mohapatra, S. S. Curcumin prevents human dendritic cell response to immune stimulants. Biochem.Biophys.Res Commun. 9-26-2008;374:431-436. View abstract.
  1069. Maher, P., Akaishi, T., Schubert, D., and Abe, K. A pyrazole derivative of curcumin enhances memory. Neurobiol.Aging 2010;31:706-709. View abstract.
  1070. Fiorillo, C., Becatti, M., Pensalfini, A., Cecchi, C., Lanzilao, L., Donzelli, G., Nassi, N., Giannini, L., Borchi, E., and Nassi, P. Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways. Free Radic.Biol.Med. 9-15-2008;45:839-846. View abstract.
  1071. Kalpana, S., Dhananjay, S., Anju, B., Lilly, G., and Sai, Ram M. Cobalt chloride attenuates hypobaric hypoxia induced vascular leakage in rat brain: molecular mechanisms of action of cobalt chloride. Toxicol Appl.Pharmacol 9-15-2008;231:354-363. View abstract.
  1072. Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., and Kurzrock, R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 7-15-2008;14:4491-4499. View abstract.
  1073. Lin, C. W., Hou, W. C., Shen, S. C., Juan, S. H., Ko, C. H., Wang, L. M., and Chen, Y. C. Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 2008;29:1807-1815. View abstract.
  1074. Tseng, Y. H., Chang, K. W., Liu, C. J., Lin, C. Y., Yang, S. C., and Lin, S. C. Areca nut extract represses migration and differentiation while activating matrix metalloproteinase-9 of normal gingival epithelial cells. J Periodontal Res 2008;43:490-499. View abstract.
  1075. Li, Y., Li, S., Han, Y., Liu, J., Zhang, J., Li, F., Wang, Y., Liu, X., and Yao, L. Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells. Eur.J Pharmacol 9-4-2008;591(1-3):252-258. View abstract.
  1076. Hong, W., Chen, D. W., Zhao, X. L., Qiao, M. X., and Hu, H. Y. [Preparation and study in vitro of long-circulating nanoliposomes of curcumin]. Zhongguo Zhong.Yao Za Zhi. 2008;33:889-892. View abstract.
  1077. Xu, D. H., Wang, S., Mei, X. T., Luo, X. J., and Xu, S. B. [Studies on solubility enhancement of curcumin by Polyvinylpyrrolidione K30]. Zhong.Yao Cai. 2008;31:438-442. View abstract.
  1078. Dohare, P., Garg, P., Jain, V., Nath, C., and Ray, M. Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. Behav.Brain Res 11-21-2008;193:289-297. View abstract.
  1079. Wang, W. Z., Cheng, J., Luo, J., and Zhuang, S. M. Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett. 8-6-2008;582:2689-2695. View abstract.
  1080. Sun, D. I., Nizamutdinova, I. T., Kim, Y. M., Cai, X. F., Lee, J. J., Kang, S. S., Kim, Y. S., Kang, K. M., Chai, G. Y., Chang, K. C., and Kim, H. J. Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression. Int.Immunopharmacol. 2008;8:1272-1281. View abstract.
  1081. Shishu, Gupta, N., and Aggarwal, N. Bioavailability enhancement and targeting of stomach tumors using gastro-retentive floating drug delivery system of curcumin--"a technical note". AAPS.PharmSciTech. 2008;9:810-813. View abstract.
  1082. Srinivasan, M., Sudheer, A. R., Rajasekaran, K. N., and Menon, V. P. Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro. Chem.Biol.Interact. 10-22-2008;176:1-8. View abstract.
  1083. Binion, D. G., Otterson, M. F., and Rafiee, P. Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut 2008;57:1509-1517. View abstract.
  1084. Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., III, Li, X., and Safe, S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 7-1-2008;68:5345-5354. View abstract.
  1085. Narasimhan, M. and Ammanamanchi, S. Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. Cancer Res 7-1-2008;68:5185-5192. View abstract.
  1086. Kang, E. S., Kim, G. H., Kim, H. J., Woo, I. S., Ham, S. A., Jin, H., Kim, M. Y., Kim, H. J., Lee, J. H., Chang, K. C., Seo, H. G., and Hwang, J. Y. Nrf2 regulates curcumin-induced aldose reductase expression indirectly via nuclear factor-kappaB. Pharmacol Res 2008;58:15-21. View abstract.
  1087. Usharani, P., Mateen, A. A., Naidu, M. U., Raju, Y. S., and Chandra, N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R.D. 2008;9:243-250. View abstract.
  1088. Kumar, A. and Singh, A. Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. Phytomedicine. 2008;15:577-586. View abstract.
  1089. Yu, L., Wu, W. K., Li, Z. J., Wong, H. P., Tai, E. K., Li, H. T., Wu, Y. C., and Cho, C. H. E series of prostaglandin receptor 2-mediated activation of extracellular signal-regulated kinase/activator protein-1 signaling is required for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma. J Pharmacol Exp.Ther. 2008;327:258-267. View abstract.
  1090. Lin, R., Chen, X., Li, W., Han, Y., Liu, P., and Pi, R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci.Lett. 8-8-2008;440:344-347. View abstract.
  1091. Park, S. Y., Kim, H. S., Cho, E. K., Kwon, B. Y., Phark, S., Hwang, K. W., and Sul, D. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem.Toxicol 2008;46:2881-2887. View abstract.
  1092. Banerjee, A., Kunwar, A., Mishra, B., and Priyadarsini, K. I. Concentration dependent antioxidant/pro-oxidant activity of curcumin studies from AAPH induced hemolysis of RBCs. Chem.Biol.Interact. 7-30-2008;174:134-139. View abstract.
  1093. Pathak, N. and Khandelwal, S. Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice. Biometals 2008;21:649-661. View abstract.
  1094. Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., and Brenner, D. E. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol.Biomarkers Prev. 2008;17:1411-1417. View abstract.
  1095. Malik, M., Mendoza, M., Payson, M., and Catherino, W. H. Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil.Steril. 2009;91(5 Suppl):2177-2184. View abstract.
  1096. Yang, C. S., Sang, S., Lambert, J. D., and Lee, M. J. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol.Nutr.Food Res 2008;52 Suppl 1:S139-S151. View abstract.
  1097. Candan, N. and Tuzmen, N. Very rapid quantification of malondialdehyde (MDA) in rat brain exposed to lead, aluminium and phenolic antioxidants by high-performance liquid chromatography-fluorescence detection. Neurotoxicology 2008;29:708-713. View abstract.
  1098. Gonzales, A. M. and Orlando, R. A. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr.Metab (Lond) 2008;5:17. View abstract.
  1099. Ak, T. and Gulcin, I. Antioxidant and radical scavenging properties of curcumin. Chem.Biol.Interact. 7-10-2008;174:27-37. View abstract.
  1100. Mathuria, N. and Verma, R. J. Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice--an in vitro study. Acta Pol.Pharm 2007;64:413-416. View abstract.
  1101. Francy-Guilford, J. and Pezzuto, J. M. Mechanisms of cancer chemopreventive agents: a perspective. Planta Med. 2008;74:1644-1650. View abstract.
  1102. Sahu, A., Bora, U., Kasoju, N., and Goswami, P. Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater. 2008;4:1752-1761. View abstract.
  1103. Araki, Y., Fann, M., Wersto, R., and Weng, N. P. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J Immunol. 6-15-2008;180:8102-8108. View abstract.
  1104. Papiez, M. A., Kaja, M., and Gebarowska, A. Age-dependent different action of curcumin in thyroid of rat. Folia Histochem.Cytobiol. 2008;46:205-211. View abstract.
  1105. Sun, Y., Lee, C. C., Hung, W. C., Chen, F. Y., Lee, M. T., and Huang, H. W. The bound states of amphipathic drugs in lipid bilayers: study of curcumin. Biophys.J 2008;95:2318-2324. View abstract.
  1106. Bandyopadhyaya, G., Sinha, S., Chattopadhyay, B. D., and Chakraborty, A. Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein. Eur.J Pharmacol 7-7-2008;588(2-3):151-157. View abstract.
  1107. Das, R., Roy, A., Dutta, N., and Majumder, H. K. Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis. 2008;13:867-882. View abstract.
  1108. Tong, K. M., Shieh, D. C., Chen, C. P., Tzeng, C. Y., Wang, S. P., Huang, K. C., Chiu, Y. C., Fong, Y. C., and Tang, C. H. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts. Cell Signal. 2008;20:1478-1488. View abstract.
  1109. Bian, F., Zhang, M. C., and Zhu, Y. Inhibitory effect of curcumin on corneal neovascularization in vitro and in vivo. Ophthalmologica 2008;222:178-186. View abstract.
  1110. Lopez-Lazaro, M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol.Nutr.Food Res 2008;52 Suppl 1:S103-S127. View abstract.
  1111. Yodkeeree, S., Chaiwangyen, W., Garbisa, S., and Limtrakul, P. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr.Biochem. 2009;20:87-95. View abstract.
  1112. Bakhshi, J., Weinstein, L., Poksay, K. S., Nishinaga, B., Bredesen, D. E., and Rao, R. V. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis. 2008;13:904-914. View abstract.
  1113. Gowda, N. K., Ledoux, D. R., Rottinghaus, G. E., Bermudez, A. J., and Chen, Y. C. Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poult.Sci. 2008;87:1125-1130. View abstract.
  1114. Dohare, P., Varma, S., and Ray, M. Curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury. Nitric.Oxide. 2008;19:1-11. View abstract.
  1115. Pari, L., Tewas, D., and Eckel, J. Role of curcumin in health and disease. Arch.Physiol Biochem. 2008;114:127-149. View abstract.
  1116. Kunnumakkara, A. B., Anand, P., and Aggarwal, B. B. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 10-8-2008;269:199-225. View abstract.
  1117. Braumann, C., Tangermann, J., Jacobi, C. A., Muller, J. M., and Dubiel, W. Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini.Rev.Med.Chem. 2008;8:421-428. View abstract.
  1118. Carroll, C. E., Ellersieck, M. R., and Hyder, S. M. Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells. Menopause. 2008;15:570-574. View abstract.
  1119. Chearwae, W. and Bright, J. J. 15-deoxy-Delta-prostaglandin J and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol. 2008;28:558-570. View abstract.
  1120. McPhee, D. Withdrawn paper: antibacterial effect of five Zingiberaceae essential oils by Laohakunjit et al., Molecules 2007, 12. Molecules. 2008;13:488-489. View abstract.
  1121. Shen, Y. and Yu, L. C. Potential protection of curcumin against hypoxia-induced decreases in beta-III tubulin content in rat prefrontal cortical neurons. Neurochem.Res 2008;33:2112-2117. View abstract.
  1122. Leung, M. H., Colangelo, H., and Kee, T. W. Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis. Langmuir 6-3-2008;24:5672-5675. View abstract.
  1123. Hsieh, H. L., Sun, C. C., Wang, T. S., and Yang, C. M. PKC-delta/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE production in rat vascular smooth muscle cells. Biochim.Biophys.Acta 2008;1783:1563-1575. View abstract.
  1124. Boriwanwattanarak, P., Ingkaninan, K., Khorana, N., and Viyoch, J. Development of curcuminoids hydrogel patch using chitosan from various sources as controlled-release matrix. Int.J Cosmet.Sci. 2008;30:205-218. View abstract.
  1125. Rolland, S. G. and Bruel, C. A. Sulphur and nitrogen regulation of the protease-encoding ACP1 gene in the fungus Botrytis cinerea: correlation with a phospholipase D activity. Microbiology 2008;154(Pt 5):1464-1473. View abstract.
  1126. Miller, M., Chen, S., Woodliff, J., and Kansra, S. Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells. Endocrinology 2008;149:4158-4167. View abstract.
  1127. Guo, L. Y., Cai, X. F., Lee, J. J., Kang, S. S., Shin, E. M., Zhou, H. Y., Jung, J. W., and Kim, Y. S. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch.Pharm Res 2008;31:490-496. View abstract.
  1128. Carter, A. Curry compound fights cancer in the clinic. J Natl.Cancer Inst. 5-7-2008;100:616-617. View abstract.
  1129. Ye, M., Liu, B. C., Jia, X. W., Gao, A., Jiao, S., and Zhang, F. M. [Activated protein 1-cyclin D1/E2F 1 pathways involved in cell cycle changes induced by benzo (a) pyrene]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:72-76. View abstract.
  1130. Kochhar, S. and Kochhar, V. K. Identification and characterization of a super-stable Cu-Zn SOD from leaves of turmeric (Curcuma longa L.). Planta 2008;228:307-318. View abstract.
  1131. Zhu, J., Zeng, X., O'Neal, M., Schultz, G., Tucker, B., Coats, J., Bartholomay, L., and Xue, R. D. Mosquito larvicidal activity of botanical-based mosquito repellents. J Am.Mosq.Control Assoc. 2008;24:161-168. View abstract.
  1132. Tang, J., Wang, J., Pan, C., Ren, L., and Huang, N. [Preparation and anticoagulation of curcumin/poly(lactic acid-co-glycol acid) composite films]. Sheng Wu Yi.Xue.Gong.Cheng Xue.Za Zhi. 2008;25:113-116. View abstract.
  1133. Yuan, H. Y., Kuang, S. Y., Zheng, X., Ling, H. Y., Yang, Y. B., Yan, P. K., Li, K., and Liao, D. F. Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells. Acta Pharmacol Sin. 2008;29:555-563. View abstract.
  1134. Thangapazham, R. L., Puri, A., Tele, S., Blumenthal, R., and Maheshwari, R. K. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int.J Oncol. 2008;32:1119-1123. View abstract.
  1135. Watson, J. L., Hill, R., Lee, P. W., Giacomantonio, C. A., and Hoskin, D. W. Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner. Exp.Mol.Pathol. 2008;84:230-233. View abstract.
  1136. Meja, K. K., Rajendrasozhan, S., Adenuga, D., Biswas, S. K., Sundar, I. K., Spooner, G., Marwick, J. A., Chakravarty, P., Fletcher, D., Whittaker, P., Megson, I. L., Kirkham, P. A., and Rahman, I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am.J Respir.Cell Mol.Biol. 2008;39:312-323. View abstract.
  1137. Wang, R., Li, Y. B., Li, Y. H., Xu, Y., Wu, H. L., and Li, X. J. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res 5-19-2008;1210:84-91. View abstract.
  1138. Begum, A. N., Jones, M. R., Lim, G. P., Morihara, T., Kim, P., Heath, D. D., Rock, C. L., Pruitt, M. A., Yang, F., Hudspeth, B., Hu, S., Faull, K. F., Teter, B., Cole, G. M., and Frautschy, S. A. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp.Ther. 2008;326:196-208. View abstract.
  1139. Feng, B., Chen, S., Chiu, J., George, B., and Chakrabarti, S. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Am.J Physiol Endocrinol.Metab 2008;294:E1119-E1126. View abstract.
  1140. Huang, S., Zhao, L., Kim, K., Lee, D. S., and Hwang, D. H. Inhibition of Nod2 signaling and target gene expression by curcumin. Mol.Pharmacol 2008;74:274-281. View abstract.
  1141. Vijayalakshmi, B., Kumar, G. S., and Salimath, P. V. Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats. J Diabetes Complications 2009;23:71-76. View abstract.
  1142. Rajeswari, A. and Sabesan, M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology. 2008;16:96-99. View abstract.
  1143. Weisberg, S. P., Leibel, R., and Tortoriello, D. V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008;149:3549-3558. View abstract.
  1144. Kurup, V. P. and Barrios, C. S. Immunomodulatory effects of curcumin in allergy. Mol.Nutr.Food Res 2008;52:1031-1039. View abstract.
  1145. Seo, K. I., Choi, M. S., Jung, U. J., Kim, H. J., Yeo, J., Jeon, S. M., and Lee, M. K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol.Nutr.Food Res 2008;52:995-1004. View abstract.
  1146. Adhikari, S., Indira, Priyadarsini K., and Mukherjee, T. Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants. J Clin Biochem.Nutr. 2007;40:174-183. View abstract.
  1147. Chen, W., Bacanamwo, M., and Harrison, D. G. Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. J Biol.Chem. 6-13-2008;283:16293-16298. View abstract.
  1148. Su, C. C., Yang, J. S., Lin, S. Y., Lu, H. F., Lin, S. S., Chang, Y. H., Huang, W. W., Li, Y. C., Chang, S. J., and Chung, J. G. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo 2008;22:63-68. View abstract.
  1149. Yoysungnoen, P., Wirachwong, P., Changtam, C., Suksamrarn, A., and Patumraj, S. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World J Gastroenterol. 4-7-2008;14:2003-2009. View abstract.
  1150. Lee, J. H., Kim, J. W., Ko, N. Y., Mun, S. H., Her, E., Kim, B. K., Han, J. W., Lee, H. Y., Beaven, M. A., Kim, Y. M., and Choi, W. S. Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol. 2008;121:1225-1231. View abstract.
  1151. Dong, J., Lu, D. X., Pan, R., and Tang, H. M. [Effect and mechanism of curcumin on learning and memory dysfunction induced by gp120 in rats]. Xi.Bao.Yu Fen.Zi.Mian.Yi.Xue.Za Zhi. 2008;24:328-331. View abstract.
  1152. Mukherjee, S., Roy, M., Dey, S., and Bhattacharya, R. K. A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn. J Clin Biochem.Nutr. 2007;41:32-42. View abstract.
  1153. Deng, G., Yu, J. H., Ye, Z. Q., and Hu, Z. Q. [Curcumin inhibits the expression of vascular endothelial growth factor and androgen-independent prostate cancer cell line PC-3 in vitro]. Zhonghua Nan.Ke.Xue. 2008;14:116-121. View abstract.
  1154. Varalakshmi, Ch, Ali, A. M., Pardhasaradhi, B. V., Srivastava, R. M., Singh, S., and Khar, A. Immunomodulatory effects of curcumin: in-vivo. Int.Immunopharmacol. 2008;8:688-700. View abstract.
  1155. Mackenzie, G. G., Queisser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M., and Oteiza, P. I. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int.J Cancer 7-1-2008;123:56-65. View abstract.
  1156. Goel, A., Jhurani, S., and Aggarwal, B. B. Multi-targeted therapy by curcumin: how spicy is it? Mol.Nutr.Food Res 2008;52:1010-1030. View abstract.
  1157. Freudlsperger, C., Greten, J., and Schumacher, U. Curcumin induces apoptosis in human neuroblastoma cells via inhibition of NFkappaB. Anticancer Res 2008;28(1A):209-214. View abstract.
  1158. Kunnumakkara, A. B., Diagaradjane, P., Guha, S., Deorukhkar, A., Shentu, S., Aggarwal, B. B., and Krishnan, S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 4-1-2008;14:2128-2136. View abstract.
  1159. Jia, L., Wang, H., Qu, S., Miao, X., and Zhang, J. CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma. IUBMB.Life 2008;60:57-63. View abstract.
  1160. Sun, J., Guo, W., Ben, Y., Jiang, J., Tan, C., Xu, Z., Wang, X., and Bai, C. Preventive effects of curcumin and dexamethasone on lung transplantation-associated lung injury in rats. Crit Care Med. 2008;36:1205-1213. View abstract.
  1161. Subudhi, U., Das, K., Paital, B., Bhanja, S., and Chainy, G. B. Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin. Chem.Biol.Interact. 5-28-2008;173:105-114. View abstract.
  1162. Lu, B., Xu, L., Yu, L., and Zhang, L. Extract of radix curcumae prevents gastric cancer in rats. Digestion 2008;77:87-91. View abstract.
  1163. Murugan, P., Pari, L., and Rao, C. A. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. J Biosci. 2008;33:63-72. View abstract.
  1164. Bayrak, O., Uz, E., Bayrak, R., Turgut, F., Atmaca, A. F., Sahin, S., Yildirim, M. E., Kaya, A., Cimentepe, E., and Akcay, A. Curcumin protects against ischemia/reperfusion injury in rat kidneys. World J Urol. 2008;26:285-291. View abstract.
  1165. Elseweidy, M. M., Younis, N. N., Amin, R. S., Abdallah, F. R., Fathy, A. M., and Yousif, Z. A. Effect of some natural products either alone or in combination on gastritis induced in experimental rats. Dig.Dis.Sci. 2008;53:1774-1784. View abstract.
  1166. Yang, S., Zhang, D., Yang, Z., Hu, X., Qian, S., Liu, J., Wilson, B., Block, M., and Hong, J. S. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem.Res 2008;33:2044-2053. View abstract.
  1167. Kim, S. J., Son, T. G., Park, H. R., Park, M., Kim, M. S., Kim, H. S., Chung, H. Y., Mattson, M. P., and Lee, J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol.Chem. 5-23-2008;283:14497-14505. View abstract.
  1168. Hsu, H. Y., Chu, L. C., Hua, K. F., and Chao, L. K. Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. J Cell Physiol 2008;215:603-612. View abstract.
  1169. Novak, Kujundzic R., Grbesa, I., Ivkic, M., Katdare, M., and Gall-Troselj, K. Curcumin downregulates H19 gene transcription in tumor cells. J Cell Biochem. 8-1-2008;104:1781-1792. View abstract.
  1170. Sun, M., Estrov, Z., Ji, Y., Coombes, K. R., Harris, D. H., and Kurzrock, R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol.Cancer Ther. 2008;7:464-473. View abstract.
  1171. Ma, Q. L., Yang, F., Calon, F., Ubeda, O. J., Hansen, J. E., Weisbart, R. H., Beech, W., Frautschy, S. A., and Cole, G. M. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol.Chem. 5-16-2008;283:14132-14143. View abstract.
  1172. Tian, B., Wang, Z., Zhao, Y., Wang, D., Li, Y., Ma, L., Li, X., Li, J., Xiao, N., Tian, J., and Rodriguez, R. Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model. Cancer Lett. 6-18-2008;264:299-308. View abstract.
  1173. Abu-Rizq, H. A., Mansour, M. H., Safer, A. M., and Afzal, M. Cyto-protective and immunomodulating effect of Curcuma longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Inflammopharmacology. 2008;16:87-95. View abstract.
  1174. Lin, J. and Chen, A. Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest 2008;88:529-540. View abstract.
  1175. Antonio, A. M. and Druse, M. J. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res 4-14-2008;1204:16-23. View abstract.
  1176. Dinkova-Kostova, A. T. and Talalay, P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol.Nutr.Food Res 2008;52 Suppl 1:S128-S138. View abstract.
  1177. Kim, K. M., Pae, H. O., Zhung, M., Ha, H. Y., Ha, Y. A., Chai, K. Y., Cheong, Y. K., Kim, J. M., and Chung, H. T. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages. Biomed.Pharmacother. 2008;62:630-636. View abstract.
  1178. Hatcher, H., Planalp, R., Cho, J., Torti, F. M., and Torti, S. V. Curcumin: from ancient medicine to current clinical trials. Cell Mol.Life Sci. 2008;65:1631-1652. View abstract.
  1179. Mathuria, N. and Verma, R. J. Ameliorative effect of curcumin on aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice. Acta Pol.Pharm 2007;64:497-502. View abstract.
  1180. Shu, J. C., Wang, H. L., Ye, G. R., He, Y. J., Lu, X., and Fang, L. [The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine]. Zhong.Yao Cai. 2007;30:1421-1425. View abstract.
  1181. Garg, R., Gupta, S., and Maru, G. B. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis 2008;29:1022-1032. View abstract.
  1182. Bichucher, A. M. and Kozlov, L. V. [Effect of medicinal preparations on the complement: inhibition of subcomponent C1q binding to a target]. Eksp.Klin.Farmakol. 2007;70:25-28. View abstract.
  1183. Choi, B. H., Kim, C. G., Bae, Y. S., Lim, Y., Lee, Y. H., and Shin, S. Y. p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res. 3-1-2008;68:1369-1377. View abstract.
  1184. Wu, C. Y., Hsieh, H. L., Sun, C. C., Tseng, C. P., and Yang, C. M. IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes. J Neurochem. 2008;105:1499-1512. View abstract.
  1185. Ding, Z. S., Jiang, F. S., Chen, N. P., Lv, G. Y., and Zhu, C. G. Isolation and identification of an anti-tumor component from leaves of Impatiens balsamina. Molecules. 2008;13:220-229. View abstract.
  1186. Aravindan, N., Madhusoodhanan, R., Ahmad, S., Johnson, D., and Herman, T. S. Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol.Ther. 2008;7:569-576. View abstract.
  1187. Li, X., Hu, Y. B., Jiang, H. Y., Wang, J. S., and Wen, J. F. [Role of activator protain-1 in pathogenesis of silicosis: an in-vitro study]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:12-15. View abstract.
  1188. Jia, X. W., Liu, B. C., Shi, X. L., Gao, A., Ye, M., Zhang, F. M., Liu, H. F., and Jiao, S. [ERK, JNK/AP-1 pathway was involved in silica-induced cell cycle changes]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:3-6. View abstract.
  1189. Panchal, H. D., Vranizan, K., Lee, C. Y., Ho, J., Ngai, J., and Timiras, P. S. Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets. Neurochem.Res 2008;33:1701-1710. View abstract.
  1190. Morimoto, T., Sunagawa, Y., Kawamura, T., Takaya, T., Wada, H., Nagasawa, A., Komeda, M., Fujita, M., Shimatsu, A., Kita, T., and Hasegawa, K. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 2008;118:868-878. View abstract.
  1191. Li, H. L., Liu, C., de Couto, G., Ouzounian, M., Sun, M., Wang, A. B., Huang, Y., He, C. W., Shi, Y., Chen, X., Nghiem, M. P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A. K., Kirshenbaum, L. A., and Liu, P. P. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008;118:879-893. View abstract.
  1192. Kaur, C. and Ling, E. A. Blood brain barrier in hypoxic-ischemic conditions. Curr.Neurovasc.Res 2008;5:71-81. View abstract.
  1193. Rudrappa, T. and Bais, H. P. Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J Agric.Food Chem. 3-26-2008;56:1955-1962. View abstract.
  1194. Jacob, A., Wu, R., Zhou, M., and Wang, P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR.Res 2007;2007:89369. View abstract.
  1195. Kimura, K., Teranishi, S., Fukuda, K., Kawamoto, K., and Nishida, T. Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-alpha in a manner dependent on NF-kappaB. Invest Ophthalmol.Vis.Sci. 2008;49:565-571. View abstract.
  1196. Lee, S. S., Tsai, C. H., Ho, Y. C., and Chang, Y. C. The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncol. 2008;44:884-890. View abstract.
  1197. Lee, C. W., Lin, C. C., Luo, S. F., Lee, H. C., Lee, I. T., Aird, W. C., Hwang, T. L., and Yang, C. M. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells. Mol.Pharmacol 2008;73:1454-1464. View abstract.
  1198. Song, W. B., Zhang, Z. S., and Xiao, B. [Protective effect of curcumin against methotrexate-induced small intestinal damage in rats]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2008;28:119-121. View abstract.
  1199. Wei, S. M., Yan, Z. Z., and Zhou, J. Curcumin attenuates ischemia-reperfusion injury in rat testis. Fertil.Steril. 2009;91:271-277. View abstract.
  1200. Fujiwara, H., Hosokawa, M., Zhou, X., Fujimoto, S., Fukuda, K., Toyoda, K., Nishi, Y., Fujita, Y., Yamada, K., Yamada, Y., Seino, Y., and Inagaki, N. Curcumin inhibits glucose production in isolated mice hepatocytes. Diabetes Res Clin Pract. 2008;80:185-191. View abstract.
  1201. Ji, C., Cao, C., Lu, S., Kivlin, R., Amaral, A., Kouttab, N., Yang, H., Chu, W., Bi, Z., Di, W., and Wan, Y. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother.Pharmacol 2008;62:857-865. View abstract.
  1202. Lee, H. S., Jung, K. K., Cho, J. Y., Rhee, M. H., Hong, S., Kwon, M., Kim, S. H., and Kang, S. Y. Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation. Pharmazie 2007;62:937-942. View abstract.
  1203. Kim, Y. S., Bahn, K. N., Hah, C. K., Gang, H. I., and Ha, Y. L. Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris. J Food Sci. 2008;73:T16-T20. View abstract.
  1204. Kadoma, Y. and Fujisawa, S. Comparative radical-scavenging activity of curcumin and tetrahydrocurcumin with thiols as measured by the induction period method. In Vivo 2007;21:979-982. View abstract.
  1205. Son, Y. H., Jeong, Y. T., Lee, K. A., Choi, K. H., Kim, S. M., Rhim, B. Y., and Kim, K. Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells. J Cardiovasc.Pharmacol 2008;51:71-77. View abstract.
  1206. Hail, N., Jr. Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis. Free Radic.Biol.Med. 4-1-2008;44:1382-1393. View abstract.
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  1208. Shukla, P. K., Khanna, V. K., Ali, M. M., Khan, M. Y., and Srimal, R. C. Anti-ischemic effect of curcumin in rat brain. Neurochem.Res 2008;33:1036-1043. View abstract.
  1209. Tikoo, K., Meena, R. L., Kabra, D. G., and Gaikwad, A. B. Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br.J Pharmacol 2008;153:1225-1231. View abstract.
  1210. Billerey-Larmonier, C., Uno, J. K., Larmonier, N., Midura, A. J., Timmermann, B., Ghishan, F. K., and Kiela, P. R. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent. Inflamm.Bowel.Dis. 2008;14:780-793. View abstract.
  1211. Riemer, C., Burwinkel, M., Schwarz, A., Gultner, S., Mok, S. W., Heise, I., Holtkamp, N., and Baier, M. Evaluation of drugs for treatment of prion infections of the central nervous system. J Gen.Virol. 2008;89(Pt 2):594-597. View abstract.
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  1214. Kutluay, S. B., Doroghazi, J., Roemer, M. E., and Triezenberg, S. J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 4-10-2008;373:239-247. View abstract.
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  1216. Liao, Y. F., Hung, H. C., Hour, T. C., Hsu, P. C., Kao, M. C., Tsay, G. J., and Liu, G. Y. Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Sci. 2-13-2008;82(7-8):367-375. View abstract.
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  1220. Riva, D. A., Fernandez-Larrosa, P. N., Dolcini, G. L., Martinez-Peralta, L. A., Coulombie, F. C., and Mersich, S. E. Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Arch.Virol. 2008;153:561-565. View abstract.
  1221. Jagatha, B., Mythri, R. B., Vali, S., and Bharath, M. M. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic.Biol.Med. 3-1-2008;44:907-917. View abstract.
  1222. Mathuria, N. and Verma, R. J. Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa. Fertil.Steril. 2008;90:775-780. View abstract.
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  1227. Tsunoda, K., Kitange, G., Anda, T., Shabani, H. K., Kaminogo, M., Shibata, S., and Nagata, I. Expression of the constitutively activated RelA/NF-kappaB in human astrocytic tumors and the in vitro implication in the regulation of urokinase-type plasminogen activator, migration, and invasion. Brain Tumor Pathol. 2005;22:79-87. View abstract.
  1228. Kanitkar, M. and Bhonde, R. R. Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation. Life Sci. 1-16-2008;82(3-4):182-189. View abstract.
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  1231. Lopez-Lazaro, M., Willmore, E., Jobson, A., Gilroy, K. L., Curtis, H., Padget, K., and Austin, C. A. Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat.Prod. 2007;70:1884-1888. View abstract.
  1232. Walters, D. K., Muff, R., Langsam, B., Born, W., and Fuchs, B. Cytotoxic effects of curcumin on osteosarcoma cell lines. Invest New Drugs 2008;26:289-297. View abstract.
  1233. Srinivasan, K. and Sambaiah, K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int.J Vitam.Nutr.Res 1991;61:364-369. View abstract.
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  1236. Prunotto, M., Bacchetta, M., Jayaraman, S., Galloni, M., Van Eys, G., Gabbiani, G., and Bochaton-Piallat, M. L. Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations. FEBS Lett. 12-22-2007;581:5847-5851. View abstract.
  1237. Suryanarayana, P., Satyanarayana, A., Balakrishna, N., Kumar, P. U., and Reddy, G. B. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med.Sci.Monit. 2007;13:BR286-BR292. View abstract.
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  1240. Anuchapreeda, S., Tima, S., Duangrat, C., and Limtrakul, P. Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines. Cancer Chemother.Pharmacol 2008;62:585-594. View abstract.
  1241. Bishnoi, M., Chopra, K., and Kulkarni, S. K. Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain. Pharmacol Biochem.Behav. 2008;88:511-522. View abstract.
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  1245. Farombi, E. O., Shrotriya, S., Na, H. K., Kim, S. H., and Surh, Y. J. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem.Toxicol 2008;46:1279-1287. View abstract.
  1246. Li, H., van Berlo, D., Shi, T., Speit, G., Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl.Pharmacol 2-15-2008;227:115-124. View abstract.
  1247. Verschoyle, R. D., Steward, W. P., and Gescher, A. J. Putative cancer chemopreventive agents of dietary origin-how safe are they? Nutr.Cancer 2007;59:152-162. View abstract.
  1248. Bachmeier, B. E., Mohrenz, I. V., Mirisola, V., Schleicher, E., Romeo, F., Hohneke, C., Jochum, M., Nerlich, A. G., and Pfeffer, U. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis 2008;29:779-789. View abstract.
  1249. Anand, P., Kunnumakkara, A. B., Newman, R. A., and Aggarwal, B. B. Bioavailability of curcumin: problems and promises. Mol.Pharm 2007;4:807-818. View abstract.
  1250. Saja, K., Babu, M. S., Karunagaran, D., and Sudhakaran, P. R. Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells. Int.Immunopharmacol. 12-15-2007;7:1659-1667. View abstract.
  1251. Hafner-Bratkovic, I., Gaspersic, J., Smid, L. M., Bresjanac, M., and Jerala, R. Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrP(Sc) accumulation. J Neurochem. 2008;104:1553-1564. View abstract.
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  1254. Usta, M., Wortelboer, H. M., Vervoort, J., Boersma, M. G., Rietjens, I. M., van Bladeren, P. J., and Cnubben, N. H. Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells. Chem.Res Toxicol 2007;20:1895-1902. View abstract.
  1255. Olszanecki, R., Gebska, A., and Korbut, R. The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin. Basic Clin Pharmacol Toxicol 2007;101:411-415. View abstract.
  1256. Safavy, A., Raisch, K. P., Mantena, S., Sanford, L. L., Sham, S. W., Krishna, N. R., and Bonner, J. A. Design and development of water-soluble curcumin conjugates as potential anticancer agents. J Med.Chem. 11-29-2007;50:6284-6288. View abstract.
  1257. Muriel, P. and Rivera-Espinoza, Y. Beneficial drugs for liver diseases. J Appl.Toxicol 2008;28:93-103. View abstract.
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  1259. Fukumori, S., Murata, T., Taguchi, M., and Hashimoto, Y. Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. Drug Metab Pharmacokinet. 2007;22:377-381. View abstract.
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  1261. Sakla, M. S. and Lorson, C. L. Induction of full-length survival motor neuron by polyphenol botanical compounds. Hum.Genet. 2008;122:635-643. View abstract.
  1262. Manjunatha, H. and Srinivasan, K. Hypolipidemic and antioxidant effects of dietary curcumin and capsaicin in induced hypercholesterolemic rats. Lipids 2007;42:1133-1142. View abstract.
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  1264. Ma, Z., Haddadi, A., Molavi, O., Lavasanifar, A., Lai, R., and Samuel, J. Micelles of poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed.Mater.Res A 2008;86:300-310. View abstract.
  1265. Rathore, P., Dohare, P., Varma, S., Ray, A., Sharma, U., Jagannathan, N. R., and Ray, M. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem.Res 2008;33:1672-1682. View abstract.
  1266. Rai, D., Singh, J. K., Roy, N., and Panda, D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem.J 2-15-2008;410:147-155. View abstract.
  1267. Baum, L., Cheung, S. K., Mok, V. C., Lam, L. C., Leung, V. P., Hui, E., Ng, C. C., Chow, M., Ho, P. C., Lam, S., Woo, J., Chiu, H. F., Goggins, W., Zee, B., Wong, A., Mok, H., Cheng, W. K., Fong, C., Lee, J. S., Chan, M. H., Szeto, S. S., Lui, V. W., Tsoh, J., Kwok, T. C., Chan, I. H., and Lam, C. W. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res 2007;56:509-514. View abstract.
  1268. El Banhawey, M. A., Ashry, M. A., El Ansary, A. K., and Aly, S. A. Effect of Curcuma longa or parziquantel on Schistosoma mansoni infected mice liver--histological and histochemical study. Indian J Exp.Biol. 2007;45:877-889. View abstract.
  1269. Wang, R., Xu, Y., Wu, H. L., Li, Y. B., Li, Y. H., Guo, J. B., and Li, X. J. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur.J Pharmacol 1-6-2008;578:43-50. View abstract.
  1270. Kelen, M. and Tepe, B. Chemical composition, antioxidant and antimicrobial properties of the essential oils of three Salvia species from Turkish flora. Bioresour.Technol. 2008;99:4096-4104. View abstract.
  1271. Raza, H., John, A., Brown, E. M., Benedict, S., and Kambal, A. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. Toxicol Appl.Pharmacol 1-15-2008;226:161-168. View abstract.
  1272. Pozharitskaya, O. N., Ivanova, S. A., Shikov, A. N., and Makarov, V. G. Separation and free radical-scavenging activity of major curcuminoids of Curcuma longa using HPTLC-DPPH method. Phytochem.Anal. 2008;19:236-243. View abstract.
  1273. Chen, Y., Shu, W., Chen, W., Wu, Q., Liu, H., and Cui, G. Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Pharmacol Toxicol 2007;101:427-433. View abstract.
  1274. Tomida, M., Ohtake, H., Yokota, T., Kobayashi, Y., and Kurosumi, M. Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. J Cancer Res Clin Oncol. 2008;134:551-559. View abstract.
  1275. Paramasivam, S., Thangaradjou, T., and Kannan, L. Effect of natural preservatives on the growth of histamine producing bacteria. J Environ.Biol. 2007;28:271-274. View abstract.
  1276. Mattson, M. P. Dietary factors, hormesis and health. Ageing Res Rev. 2008;7:43-48. View abstract.
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  1278. Hsieh, H. L., Sun, C. C., Wu, C. B., Wu, C. Y., Tung, W. H., Wang, H. H., and Yang, C. M. Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells. J Cell Biochem. 4-15-2008;103:1732-1746. View abstract.
  1279. Meghana, K., Sanjeev, G., and Ramesh, B. Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role. Eur.J Pharmacol 12-22-2007;577(1-3):183-191. View abstract.
  1280. Gal, S., Lichtenberg, D., Bor, A., and Pinchuk, I. Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants. Chem.Phys.Lipids 2007;150:186-203. View abstract.
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  1282. Kumar, A., Naidu, P. S., Seghal, N., and Padi, S. S. Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. J Med.Food 2007;10:486-494. View abstract.
  1283. Marin, Y. E., Wall, B. A., Wang, S., Namkoong, J., Martino, J. J., Suh, J., Lee, H. J., Rabson, A. B., Yang, C. S., Chen, S., and Ryu, J. H. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res 2007;17:274-283. View abstract.
  1284. Jin, C. Y., Lee, J. D., Park, C., Choi, Y. H., and Kim, G. Y. Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. Acta Pharmacol Sin. 2007;28:1645-1651. View abstract.
  1285. Thavara, U., Tawatsin, A., Bhakdeenuan, P., Wongsinkongman, P., Boonruad, T., Bansiddhi, J., Chavalittumrong, P., Komalamisra, N., Siriyasatien, P., and Mulla, M. S. Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand. Southeast Asian J Trop.Med.Public Health 2007;38:663-673. View abstract.
  1286. Zhang, X. C., Chen, J., Su, C. H., Yang, H. Y., and Lee, M. H. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 3-1-2008;103:1219-1230. View abstract.
  1287. Jagota, A. and Reddy, M. Y. The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal. Cell Mol.Neurobiol. 2007;27:997-1006. View abstract.
  1288. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats. Basic Clin Pharmacol Toxicol 2007;101:241-245. View abstract.
  1289. Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., and Matsumoto, K. Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biol.Pharm Bull. 2007;30:1732-1739. View abstract.
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  1292. Shinojima, N., Yokoyama, T., Kondo, Y., and Kondo, S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy. 2007;3:635-637. View abstract.
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  1294. Griffiths, N. J., Bradley, C. J., Heyderman, R. S., and Virji, M. IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1. Cell Microbiol. 2007;9:2968-2983. View abstract.
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  1296. Takahashi, M., Ishiko, T., Kamohara, H., Hidaka, H., Ikeda, O., Ogawa, M., and Baba, H. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors. Mediators.Inflamm. 2007;2007:10767. View abstract.
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  1301. Cao, J., Liu, Y., Jia, L., Zhou, H. M., Kong, Y., Yang, G., Jiang, L. P., Li, Q. J., and Zhong, L. F. Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells. Free Radic.Biol.Med. 9-15-2007;43:968-975. View abstract.
  1302. Takahashi, M., Inafuku, K., Miyagi, T., Oku, H., Wada, K., Imura, T., and Kitamoto, D. Efficient preparation of liposomes encapsulating food materials using lecithins by a mechanochemical method. J Oleo.Sci. 2006;56:35-42. View abstract.
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  1304. Ferguson, L. R. and Philpott, M. Cancer prevention by dietary bioactive components that target the immune response. Curr.Cancer Drug Targets. 2007;7:459-464. View abstract.
  1305. Park, C., Moon, D. O., Choi, I. W., Choi, B. T., Nam, T. J., Rhu, C. H., Kwon, T. K., Lee, W. H., Kim, G. Y., and Choi, Y. H. Curcumin induces apoptosis and inhibits prostaglandin E production in synovial fibroblasts of patients with rheumatoid arthritis. Int.J Mol.Med. 2007;20:365-372. View abstract.
  1306. Poma, P., Notarbartolo, M., Labbozzetta, M., Maurici, A., Carina, V., Alaimo, A., Rizzi, M., Simoni, D., and D'Alessandro, N. The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis. Int.J Mol.Med. 2007;20:329-335. View abstract.
  1307. Kamohara, H., Takahashi, M., Ishiko, T., Ogawa, M., and Baba, H. Induction of interleukin-8 (CXCL-8) by tumor necrosis factor-alpha and leukemia inhibitory factor in pancreatic carcinoma cells: Impact of CXCL-8 as an autocrine growth factor. Int.J Oncol. 2007;31:627-632. View abstract.
  1308. Kim, Y. S., Ahn, Y., Hong, M. H., Joo, S. Y., Kim, K. H., Sohn, I. S., Park, H. W., Hong, Y. J., Kim, J. H., Kim, W., Jeong, M. H., Cho, J. G., Park, J. C., and Kang, J. C. Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells. J Cardiovasc.Pharmacol 2007;50:41-49. View abstract.
  1309. Mathuria, N. and Verma, R. J. Aflatoxin induced hemolysis and its amelioration by turmeric extracts and curcumin in vitro. Acta Pol.Pharm 2007;64:165-168. View abstract.
  1310. Wen, C. C., Kuo, Y. H., Jan, J. T., Liang, P. H., Wang, S. Y., Liu, H. G., Lee, C. K., Chang, S. T., Kuo, C. J., Lee, S. S., Hou, C. C., Hsiao, P. W., Chien, S. C., Shyur, L. F., and Yang, N. S. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med.Chem. 8-23-2007;50:4087-4095. View abstract.
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  1312. Mandel, S., Amit, T., Bar-Am, O., and Youdim, M. B. Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Prog.Neurobiol. 2007;82:348-360. View abstract.
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  1314. Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104:12849-12854. View abstract.
  1315. Hammamieh, R., Sumaida, D., Zhang, X., Das, R., and Jett, M. Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. BMC.Cancer 2007;7:138. View abstract.
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  1318. Sandur, S. K., Ichikawa, H., Pandey, M. K., Kunnumakkara, A. B., Sung, B., Sethi, G., and Aggarwal, B. B. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic.Biol.Med. 8-15-2007;43:568-580. View abstract.
  1319. Kang, E. S., Woo, I. S., Kim, H. J., Eun, S. Y., Paek, K. S., Kim, H. J., Chang, K. C., Lee, J. H., Lee, H. T., Kim, J. H., Nishinaka, T., Yabe-Nishimura, C., and Seo, H. G. Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic.Biol.Med. 8-15-2007;43:535-545. View abstract.
  1320. Martelli, L., Ragazzi, E., di Mario, F., Martelli, M., Castagliuolo, I., Dal Maschio, M., Palu, G., Maschietto, M., Scorzeto, M., Vassanelli, S., and Brun, P. A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. Neurogastroenterol.Motil. 2007;19:668-674. View abstract.
  1321. Walle, T. and Walle, U. K. Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. J Pharm Pharmacol 2007;59:857-862. View abstract.
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  1324. Xu, Y., Ku, B., Cui, L., Li, X., Barish, P. A., Foster, T. C., and Ogle, W. O. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 8-8-2007;1162:9-18. View abstract.
  1325. Salmaso, S., Bersani, S., Semenzato, A., and Caliceti, P. New cyclodextrin bioconjugates for active tumour targeting. J Drug Target 2007;15:379-390. View abstract.
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  1329. Pae, H. O., Jeong, G. S., Jeong, S. O., Kim, H. S., Kim, S. A., Kim, Y. C., Yoo, S. J., Kim, H. D., and Chung, H. T. Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells. Exp.Mol.Med. 6-30-2007;39:267-277. View abstract.
  1330. Zheng, S., Yumei, F., and Chen, A. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radic.Biol.Med. 8-1-2007;43:444-453. View abstract.
  1331. Dhandapani, K. M., Mahesh, V. B., and Brann, D. W. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem. 2007;102:522-538. View abstract.
  1332. Liu, E., Wu, J., Cao, W., Zhang, J., Liu, W., Jiang, X., and Zhang, X. Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. J Neurooncol. 2007;85:263-270. View abstract.
  1333. Jain, V., Prasad, V., Pal, R., and Singh, S. Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa. J Pharm Biomed.Anal. 9-3-2007;44:1079-1086. View abstract.
  1334. Yu, Z. and Shah, D. M. Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells. Gynecol.Oncol. 2007;106:541-548. View abstract.
  1335. Adhvaryu, M. R., Reddy, N., and Parabia, M. H. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. World J Gastroenterol. 6-21-2007;13:3199-3205. View abstract.
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  1345. Miriyala, S., Panchatcharam, M., and Rengarajulu, P. Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 2007;595:359-377. View abstract.
  1346. Thangapazham, R. L., Sharma, A., and Maheshwari, R. K. Beneficial role of curcumin in skin diseases. Adv.Exp.Med.Biol. 2007;595:343-357. View abstract.
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  1364. Teichmann, A., Heuschkel, S., Jacobi, U., Presse, G., Neubert, R. H., Sterry, W., and Lademann, J. Comparison of stratum corneum penetration and localization of a lipophilic model drug applied in an o/w microemulsion and an amphiphilic cream. Eur.J Pharm Biopharm. 2007;67:699-706. View abstract.
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  1366. Vlahovic, P., Cvetkovic, T., Savic, V., and Stefanovic, V. Dietary curcumin does not protect kidney in glycerol-induced acute renal failure. Food Chem.Toxicol 2007;45:1777-1782. View abstract.
  1367. Tepe, B. Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata (Jacq), Salvia staminea (Montbret & Aucher ex Bentham) and Salvia verbenaca (L.) from Turkey. Bioresour.Technol. 2008;99:1584-1588. View abstract.
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  1369. Suresh, D. and Srinivasan, K. Studies on the in vitro absorption of spice principles--curcumin, capsaicin and piperine in rat intestines. Food Chem.Toxicol 2007;45:1437-1442. View abstract.
  1370. Marwick, J. A., Ito, K., Adcock, I. M., and Kirkham, P. A. Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert.Opin.Ther.Targets. 2007;11:745-755. View abstract.
  1371. Xia, Y., Jin, L., Zhang, B., Xue, H., Li, Q., and Xu, Y. The potentiation of curcumin on insulin-like growth factor-1 action in MCF-7 human breast carcinoma cells. Life Sci. 5-16-2007;80:2161-2169. View abstract.
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  1374. Balasubramanian, S. and Eckert, R. L. Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin. Toxicol Appl.Pharmacol 11-1-2007;224:214-219. View abstract.
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  1377. Moss, A. C. Curcumin for maintenance therapy in ulcerative colitis. Clin Gastroenterol.Hepatol. 2007;5:642. View abstract.
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  1379. Juan, H., Terhaag, B., Cong, Z., Bi-Kui, Z., Rong-Hua, Z., Feng, W., Fen-Li, S., Juan, S., Jing, T., and Wen-Xing, P. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers. Eur.J Clin Pharmacol 2007;63:663-668. View abstract.
  1380. Hauser, P. J., Han, Z., Sindhwani, P., and Hurst, R. E. Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Anticancer Res 2007;27:737-740. View abstract.
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  1393. Neuss, H., Huang, X., Hetfeld, B. K., Deva, R., Henklein, P., Nigam, S., Mall, J. W., Schwenk, W., and Dubiel, W. The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. J Mol.Med. 2007;85:961-970. View abstract.
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  1400. Grandjean-Laquerriere, A., Antonicelli, F., Gangloff, S. C., Guenounou, M., and Le Naour, R. UVB-induced IL-18 production in human keratinocyte cell line NCTC 2544 through NF-kappaB activation. Cytokine 2007;37:76-83. View abstract.
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  1402. Bhattacharyya, S., Mandal, D., Saha, B., Sen, G. S., Das, T., and Sa, G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol.Chem. 6-1-2007;282:15954-15964. View abstract.
  1403. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim.Biophys.Acta 2007;1770:989-996. View abstract.
  1404. Best, L., Elliott, A. C., and Brown, P. D. Curcumin induces electrical activity in rat pancreatic beta-cells by activating the volume-regulated anion channel. Biochem.Pharmacol 6-1-2007;73:1768-1775. View abstract.
  1405. Shih, P. C., Lee, H. H., Lai, S. C., Chen, K. M., Jiang, S. T., Chen, Y. F., and Shiow, S. J. Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. J Helminthol. 2007;81:1-5. View abstract.
  1406. Liu, D. Y., Li, X. W., Li, H., Li, X. M., and Ye, W. L. [Expression of cyclooxygenase-2 in a mouse macula densa cell lines and signal transduction of NF-kappaB and AP-1]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 2007;29:78-82. View abstract.
  1407. Shen, F. H., Fan, X. Y., Liu, B. C., Jia, X. W., Gao, A., You, B. R., Ye, M., DU, H. J., Huang, C. S., and Shi, X. L. [The activation of MAPK/cyclin D1-CDK4 signaling pathway caused by quartz]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2007;25:5-10. View abstract.
  1408. Yoon, H. and Liu, R. H. Effect of selected phytochemicals and apple extracts on NF-kappaB activation in human breast cancer MCF-7 cells. J Agric.Food Chem. 4-18-2007;55:3167-3173. View abstract.
  1409. Venkataranganna, M. V., Rafiq, M., Gopumadhavan, S., Peer, G., Babu, U. V., and Mitra, S. K. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS. World J Gastroenterol. 2-21-2007;13:1103-1107. View abstract.
  1410. Zhou, Y., Zheng, S., Lin, J., Zhang, Q. J., and Chen, A. The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab Invest 2007;87:488-498. View abstract.
  1411. Al Sadi, R. M. and Ma, T. Y. IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol. 4-1-2007;178:4641-4649. View abstract.
  1412. Kamat, A. M., Sethi, G., and Aggarwal, B. B. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. Mol.Cancer Ther. 2007;6:1022-1030. View abstract.
  1413. Lian, Q., Li, X., Shang, Y., Yao, S., Ma, L., and Jin, S. Protective effect of curcumin on endotoxin-induced acute lung injury in rats. J Huazhong.Univ Sci.Technolog.Med.Sci. 2006;26:678-681. View abstract.
  1414. Bruck, R., Ashkenazi, M., Weiss, S., Goldiner, I., Shapiro, H., Aeed, H., Genina, O., Helpern, Z., and Pines, M. Prevention of liver cirrhosis in rats by curcumin. Liver Int. 2007;27:373-383. View abstract.
  1415. Atsumi, T., Tonosaki, K., and Fujisawa, S. Comparative cytotoxicity and ROS generation by curcumin and tetrahydrocurcumin following visible-light irradiation or treatment with horseradish peroxidase. Anticancer Res 2007;27(1A):363-371. View abstract.
  1416. Sivalingam, N., Hanumantharaya, R., Faith, M., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin reduces indomethacin-induced damage in the rat small intestine. J Appl.Toxicol 2007;27:551-560. View abstract.
  1417. Wagner, H., Wierer, M., and Bauer, R. [In vitro Inhibition of Prostaglandin Biosynthesis by Essential Oils and Phenolic Compounds1.]. Planta Med. 1986;52:184-187. View abstract.
  1418. Kumar, P., Padi, S. S., Naidu, P. S., and Kumar, A. Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. Methods Find.Exp.Clin Pharmacol 2007;29:19-25. View abstract.
  1419. Aggarwal, B. B., Sethi, G., Ahn, K. S., Sandur, S. K., Pandey, M. K., Kunnumakkara, A. B., Sung, B., and Ichikawa, H. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Ann.N.Y Acad.Sci. 2006;1091:151-169. View abstract.
  1420. Mitra, A., Chakrabarti, J., Banerji, A., Chatterjee, A., and Das, B. R. Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ.Pathol.Toxicol Oncol. 2006;25:679-690. View abstract.
  1421. Ma, Z., Shayeganpour, A., Brocks, D. R., Lavasanifar, A., and Samuel, J. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed.Chromatogr. 2007;21:546-552. View abstract.
  1422. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on plasma antioxidants in streptozotocin-nicotinamide experimental diabetes. J Basic Clin Physiol Pharmacol 2006;17:231-244. View abstract.
  1423. Shankar, S. and Srivastava, R. K. Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. Int.J Oncol. 2007;30:905-918. View abstract.
  1424. Li, M., Zhang, Z., Hill, D. L., Wang, H., and Zhang, R. Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res 3-1-2007;67:1988-1996. View abstract.
  1425. Davis, J. M., Murphy, E. A., Carmichael, M. D., Zielinski, M. R., Groschwitz, C. M., Brown, A. S., Gangemi, J. D., Ghaffar, A., and Mayer, E. P. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am.J Physiol Regul.Integr.Comp Physiol 2007;292:R2168-R2173. View abstract.
  1426. Pan, C. J., Shao, Z. Y., Tang, J. J., Wang, J., and Huang, N. In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin-eluting biodegradable stent materials. J Biomed.Mater.Res A 9-1-2007;82:740-746. View abstract.
  1427. Srinivas, L., Shalini, V. K., and Shylaja, M. Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]. Arch.Biochem.Biophys. 2-1-1992;292:617-623. View abstract.
  1428. Bentzen, P. J., Lang, E., and Lang, F. Curcumin induced suicidal erythrocyte death. Cell Physiol Biochem. 2007;19(1-4):153-164. View abstract.
  1429. Bachmeier, B., Nerlich, A. G., Iancu, C. M., Cilli, M., Schleicher, E., Vene, R., Dell'Eva, R., Jochum, M., Albini, A., and Pfeffer, U. The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice. Cell Physiol Biochem. 2007;19(1-4):137-152. View abstract.
  1430. Deng, J., Grande, F., and Neamati, N. Small molecule inhibitors of Stat3 signaling pathway. Curr.Cancer Drug Targets. 2007;7:91-107. View abstract.
  1431. Kalpana, C., Sudheer, A. R., Rajasekharan, K. N., and Menon, V. P. Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med.J 2007;48:124-130. View abstract.
  1432. Jiang, J., Wang, W., Sun, Y. J., Hu, M., Li, F., and Zhu, D. Y. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. Eur.J Pharmacol 4-30-2007;561(1-3):54-62. View abstract.
  1433. Zhang, H. N., Yu, C. X., Zhang, P. J., Chen, W. W., Jiang, A. L., Kong, F., Deng, J. T., Zhang, J. Y., and Young, C. Y. Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP. Acta Pharmacol Sin. 2007;28:423-430. View abstract.
  1434. Shin, H. J., Lee, J. Y., Son, E., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., and Roh, G. S. Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice. Neurosci.Lett. 4-6-2007;416:49-54. View abstract.
  1435. Lin, C. C., Lee, C. W., Chu, T. H., Cheng, C. Y., Luo, S. F., Hsiao, L. D., and Yang, C. M. Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells. J Cell Physiol 2007;211:771-780. View abstract.
  1436. Tomren, M. A., Masson, M., Loftsson, T., and Tonnesen, H. H. Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: stability, activity and complexation with cyclodextrin. Int.J Pharm 6-29-2007;338(1-2):27-34. View abstract.
  1437. Shakibaei, M., John, T., Schulze-Tanzil, G., Lehmann, I., and Mobasheri, A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem.Pharmacol 5-1-2007;73:1434-1445. View abstract.
  1438. Shi, P., Chen, W. W., Hu, X. Y., Yu, C. X., Zhang, P. J., Jiang, A. L., and Zhang, J. Y. [Up-regulates the expression of maspin gene in prostate cancer cell line LNCaP]. Yao Xue.Xue.Bao. 2006;41:1152-1156. View abstract.
  1439. Deeb, D., Jiang, H., Gao, X., Al Holou, S., Danyluk, A. L., Dulchavsky, S. A., and Gautam, S. C. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway. J Pharmacol Exp.Ther. 2007;321:616-625. View abstract.
  1440. Shankar, S. and Srivastava, R. K. Bax and Bak genes are essential for maximum apoptotic response by curcumin, a polyphenolic compound and cancer chemopreventive agent derived from turmeric, Curcuma longa. Carcinogenesis 2007;28:1277-1286. View abstract.
  1441. Camacho-Barquero, L., Villegas, I., Sanchez-Calvo, J. M., Talero, E., Sanchez-Fidalgo, S., Motilva, V., and Alarcon, de la Lastra. Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. Int.Immunopharmacol. 2007;7:333-342. View abstract.
  1442. Calabrese, V., Guagliano, E., Sapienza, M., Mancuso, C., Butterfield, D. A., and Stella, A. M. Redox regulation of cellular stress response in neurodegenerative disorders. Ital.J Biochem. 2006;55(3-4):263-282. View abstract.
  1443. Cho, J. W., Lee, K. S., and Kim, C. W. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int.J Mol.Med. 2007;19:469-474. View abstract.
  1444. Byeon, S. R., Lee, J. H., Sohn, J. H., Kim, D. C., Shin, K. J., Yoo, K. H., Mook-Jung, I., Lee, W. K., and Kim, D. J. Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation. Bioorg.Med.Chem.Lett. 3-1-2007;17:1466-1470. View abstract.
  1445. Dairam, A., Limson, J. L., Watkins, G. M., Antunes, E., and Daya, S. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. J Agric.Food Chem. 2-7-2007;55:1039-1044. View abstract.
  1446. Kurup, V. P., Barrios, C. S., Raju, R., Johnson, B. D., Levy, M. B., and Fink, J. N. Immune response modulation by curcumin in a latex allergy model. Clin Mol.Allergy 2007;5:1. View abstract.
  1447. Aggarwal, B. B., Banerjee, S., Bharadwaj, U., Sung, B., Shishodia, S., and Sethi, G. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem.Pharmacol 4-1-2007;73:1024-1032. View abstract.
  1448. Jung, Y., Xu, W., Kim, H., Ha, N., and Neckers, L. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochim.Biophys.Acta 2007;1773:383-390. View abstract.
  1449. Fang, H. Z., Ren, S. Q., and Shen, D. F. [Comparison of volatile oil chromatographic fingerprints of rhizoma curcumae longae and rhizoma wenyujin concisum]. Zhong.Yao Cai. 2006;29:1179-1182. View abstract.
  1450. Pari, L. and Murugan, P. Changes in glycoprotein components in streptozotocin--nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Foods Hum.Nutr. 2007;62:25-29. View abstract.
  1451. Chen, C. C., Taniguchi, T., and D'Andrea, A. The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. J Mol.Med. 2007;85:497-509. View abstract.
  1452. Weir, N. M., Selvendiran, K., Kutala, V. K., Tong, L., Vishwanath, S., Rajaram, M., Tridandapani, S., Anant, S., and Kuppusamy, P. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol.Ther. 2007;6:178-184. View abstract.
  1453. Farombi, E. O., Abarikwu, S. O., Adedara, I. A., and Oyeyemi, M. O. Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol 2007;100:43-48. View abstract.
  1454. Jagetia, G. C. and Aggarwal, B. B. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27:19-35. View abstract.
  1455. Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., and Morales, N. P. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol.Pharm Bull. 2007;30:74-78. View abstract.
  1456. Lev-Ari, S., Starr, A., Vexler, A., Karaush, V., Loew, V., Greif, J., Fenig, E., Aderka, D., and Ben Yosef, R. Inhibition of pancreatic and lung adenocarcinoma cell survival by curcumin is associated with increased apoptosis, down-regulation of COX-2 and EGFR and inhibition of Erk1/2 activity. Anticancer Res 2006;26(6B):4423-4430. View abstract.
  1457. Su, C. C., Lin, J. G., Li, T. M., Chung, J. G., Yang, J. S., Ip, S. W., Lin, W. C., and Chen, G. W. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res 2006;26(6B):4379-4389. View abstract.
  1458. Tan, T. W., Tsai, H. R., Lu, H. F., Lin, H. L., Tsou, M. F., Lin, Y. T., Tsai, H. Y., Chen, Y. F., and Chung, J. G. Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation. Anticancer Res 2006;26(6B):4361-4371. View abstract.
  1459. Skommer, J., Wlodkowic, D., and Pelkonen, J. Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Exp.Hematol. 2007;35:84-95. View abstract.
  1460. Pae, H. O., Jeong, S. O., Jeong, G. S., Kim, K. M., Kim, H. S., Kim, S. A., Kim, Y. C., Kang, S. D., Kim, B. N., and Chung, H. T. Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells. Biochem.Biophys.Res Commun. 2-23-2007;353:1040-1045. View abstract.
  1461. Landis-Piwowar, K. R., Milacic, V., Chen, D., Yang, H., Zhao, Y., Chan, T. H., Yan, B., and Dou, Q. P. The proteasome as a potential target for novel anticancer drugs and chemosensitizers. Drug Resist.Updat. 2006;9:263-273. View abstract.
  1462. Matsuo, M., Sakurai, H., Koizumi, K., and Saiki, I. Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells. Cancer Lett. 6-28-2007;251:288-295. View abstract.
  1463. Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Mancuso, C., Butterfield, D. A., and Stella, A. G. Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. Neurochem.Res 2007;32(4-5):757-773. View abstract.
  1464. Kwon, Y. and Magnuson, B. A. Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. Scand.J Gastroenterol. 2007;42:72-80. View abstract.
  1465. Zhang, K. Z., Xu, J. H., Huang, X. W., Wu, L. X., Su, Y., and Chen, Y. Z. Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells. Acta Pharmacol Sin. 2007;28:105-110. View abstract.
  1466. Mythri, R. B., Jagatha, B., Pradhan, N., Andersen, J., and Bharath, M. M. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxid.Redox.Signal. 2007;9:399-408. View abstract.
  1467. Gururajan, M., Dasu, T., Shahidain, S., Jennings, C. D., Robertson, D. A., Rangnekar, V. M., and Bondada, S. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol. 1-1-2007;178:111-121. View abstract.
  1468. Pinilla, F. G. The impact of diet and exercise on brain plasticity and disease. Nutr.Health 2006;18:277-284. View abstract.
  1469. Sharma, S., Chopra, K., Kulkarni, S. K., and Agrewala, J. N. Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Clin Exp.Immunol. 2007;147:155-163. View abstract.
  1470. Ruocco, K. M., Goncharova, E. I., Young, M. R., Colburn, N. H., McMahon, J. B., and Henrich, C. J. A high-throughput cell-based assay to identify specific inhibitors of transcription factor AP-1. J Biomol.Screen. 2007;12:133-139. View abstract.
  1471. Mishra, S., Mishra, J. P., and Kumar, A. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. J Biol.Chem. 2-16-2007;282:4288-4300. View abstract.
  1472. Lee, C. W., Lin, C. C., Lin, W. N., Liang, K. C., Luo, S. F., Wu, C. B., Wang, S. W., and Yang, C. M. TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells. Am.J Physiol Lung Cell Mol.Physiol 2007;292:L799-L812. View abstract.
  1473. Liddle, M., Hull, C., Liu, C., and Powell, D. Contact urticaria from curcumin. Dermatitis 2006;17:196-197. View abstract.
  1474. Patumraj, S., Wongeakin, N., Sridulyakul, P., Jariyapongskul, A., Futrakul, N., and Bunnag, S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. Clin Hemorheol.Microcirc. 2006;35:481-489. View abstract.
  1475. Balasubramanian, S. and Eckert, R. L. Curcumin suppresses AP1 transcription factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes. J Biol.Chem. 3-2-2007;282:6707-6715. View abstract.
  1476. Guo, H., Yu, J. H., Chen, K., and Ye, Z. Q. [Curcumin-induced the expression of inhibitor kappaBalpha protein in human prostate cancer cells]. Zhonghua Wai Ke.Za Zhi. 9-15-2006;44:1256-1259. View abstract.
  1477. Ma, X. and Gang, D. R. Metabolic profiling of turmeric (Curcuma longa L.) plants derived from in vitro micropropagation and conventional greenhouse cultivation. J Agric.Food Chem. 12-13-2006;54:9573-9583. View abstract.
  1478. Cui, L., Miao, J., and Cui, L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob.Agents Chemother. 2007;51:488-494. View abstract.
  1479. McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., and Wigmore, S. J. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int.J Mol.Med. 2007;19:165-172. View abstract.
  1480. Lao, C. D., Demierre, M. F., and Sondak, V. K. Targeting events in melanoma carcinogenesis for the prevention of melanoma. Expert.Rev.Anticancer Ther. 2006;6:1559-1568. View abstract.
  1481. Furusu, A., Nakayama, K., Xu, Q., Konta, T., and Kitamura, M. MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha. J Cell Physiol 2007;210:703-710. View abstract.
  1482. Suh, H. W., Kang, S., and Kwon, K. S. Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling. Mol.Cell Biochem. 2007;298(1-2):187-194. View abstract.
  1483. Salimei, P. S., Marfe, G., Di Renzo, L., Di Stefano, C., Giganti, M. G., Filomeni, G., and Ciriolo, M. R. The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Front Biosci. 2007;12:1308-1317. View abstract.
  1484. Mancuso, C., Scapagini, G., Curro, D., Giuffrida Stella, A. M., De Marco, C., Butterfield, D. A., and Calabrese, V. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci. 2007;12:1107-1123. View abstract.
  1485. Kumar, N., Shibata, D., Helm, J., Coppola, D., and Malafa, M. Green tea polyphenols in the prevention of colon cancer. Front Biosci. 2007;12:2309-2315. View abstract.
  1486. Anuchapreeda, S., Thanarattanakorn, P., Sittipreechacharn, S., Tima, S., Chanarat, P., and Limtrakul, P. Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells. Arch.Pharm Res 2006;29:866-873. View abstract.
  1487. Yazawa, K., Kihara, T., Shen, H., Shimmyo, Y., Niidome, T., and Sugimoto, H. Distinct mechanisms underlie distinct polyphenol-induced neuroprotection. FEBS Lett. 12-11-2006;580(28-29):6623-6628. View abstract.
  1488. Honda, S., Aoki, F., Tanaka, H., Kishida, H., Nishiyama, T., Okada, S., Matsumoto, I., Abe, K., and Mae, T. Effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a DNA microarray study. J Agric.Food Chem. 11-29-2006;54:9055-9062. View abstract.
  1489. Kurien, B. T. and Scofield, R. H. Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification--an in vitro study. J Ethnopharmacol. 3-21-2007;110:368-373. View abstract.
  1490. Maiti, K., Mukherjee, K., Gantait, A., Saha, B. P., and Mukherjee, P. K. Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats. Int.J Pharm 2-7-2007;330(1-2):155-163. View abstract.
  1491. Ono, K., Naiki, H., and Yamada, M. The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta. Curr.Pharm Des 2006;12:4357-4375. View abstract.
  1492. Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4:1502-1506. View abstract.
  1493. Mukherjee Nee, Chakraborty S., Ghosh, U., Bhattacharyya, N. P., Bhattacharya, R. K., Dey, S., and Roy, M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol.Cell Biochem. 2007;297(1-2):31-39. View abstract.
  1494. Huang, X. R., Qi, M. X., and Kang, K. R. [Apoptosis of lens epithelial cell induced by curcumin and its mechanism]. Zhonghua Yan.Ke.Za Zhi. 2006;42:649-653. View abstract.
  1495. Ebert, B., Seidel, A., and Lampen, A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007;96:227-236. View abstract.
  1496. Pari, L. and Murugan, P. Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney. Basic Clin Pharmacol Toxicol 2006;99:329-334. View abstract.
  1497. Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54:3452-3464. View abstract.
  1498. Gupta, K. K., Bharne, S. S., Rathinasamy, K., Naik, N. R., and Panda, D. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J 2006;273:5320-5332. View abstract.
  1499. Nair, P. K., Melnick, S. J., Ramachandran, R., Escalon, E., and Ramachandran, C. Mechanism of macrophage activation by -alpha-D-glucan isolated from Tinospora cordifolia. Int.Immunopharmacol. 12-5-2006;6:1815-1824. View abstract.
  1500. Marczylo, T. H., Verschoyle, R. D., Cooke, D. N., Morazzoni, P., Steward, W. P., and Gescher, A. J. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother.Pharmacol 2007;60:171-177. View abstract.
  1501. Pan, ChJ, Tang, J. J., Weng, Y. J., Wang, J., and Huang, N. Preparation, characterization and anticoagulation of curcumin-eluting controlled biodegradable coating stents. J Control Release 2006;116:42-49. View abstract.
  1502. Tayyem, R. F., Heath, D. D., Al Delaimy, W. K., and Rock, C. L. Curcumin content of turmeric and curry powders. Nutr.Cancer 2006;55:126-131. View abstract.
  1503. Yang, F. W., Huang, J. Z., Lin, X. L., Zhen, Z. N., and Chen, X. M. [Apoptosis in nasopharyngeal carcinoma cell line NCE induced by curcumin and its molecular mechanism]. Zhonghua Er.Bi Yan.Hou Tou.Jing.Wai Ke.Za Zhi. 2006;41:612-616. View abstract.
  1504. Chen, C., Johnston, T. D., Wu, G., and Ranjan, D. Curcumin has potent liver preservation properties in an isolated perfusion model. Transplantation 10-15-2006;82:931-937. View abstract.
  1505. Khopde, M., Priyadarsini, K. I., Venkatesan, P., and Rao, M. N. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue. Biophys.Chem. 8-9-1999;80:85-91. View abstract.
  1506. Skayian, Y. and Kreydiyyeh, S. I. Tumor necrosis factor alpha alters Na+-K+ ATPase activity in rat cardiac myocytes: involvement of NF-kappaB, AP-1 and PGE2. Life Sci. 12-14-2006;80:173-180. View abstract.
  1507. Khan, A., Bryden, N. A., Polansky, M. M., and Anderson, R. A. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem.Res 1990;24:183-188. View abstract.
  1508. Thangapazham, R. L., Sharma, A., and Maheshwari, R. K. Multiple molecular targets in cancer chemoprevention by curcumin. AAPS.J 2006;8:E443-E449. View abstract.
  1509. Xu, Y., Ku, B., Tie, L., Yao, H., Jiang, W., Ma, X., and Li, X. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 11-29-2006;1122:56-64. View abstract.
  1510. Kamath, R., Jiang, Z., Sun, G., Yalowich, J. C., and Baskaran, R. c-Abl kinase regulates curcumin-induced cell death through activation of c-Jun N-terminal kinase. Mol.Pharmacol 2007;71:61-72. View abstract.
  1511. Cheng, Y., Ping, J., Liu, C., Tan, Y. Z., and Chen, G. F. Study on effects of extracts from Salvia Miltiorrhiza and Curcuma Longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat's hepatic stellate cells. Chin J Integr.Med. 2006;12:207-211. View abstract.
  1512. Sharma, S., Kulkarni, S. K., and Chopra, K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp.Pharmacol Physiol 2006;33:940-945. View abstract.
  1513. Wang, X., Wang, Q., Ives, K. L., and Evers, B. M. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res 9-15-2006;12:5346-5355. View abstract.
  1514. Mattson, M. P. and Cheng, A. Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci. 2006;29:632-639. View abstract.
  1515. Raju, T. N., Kumar, C. S., Kanth, V. R., Ramana, B. V., Reddy, P. U., Suryanarayana, P., and Reddy, G. B. Cumulative antioxidant defense against oxidative challenge in galactose-induced cataractogenesis in Wistar rats. Indian J Exp.Biol. 2006;44:733-739. View abstract.
  1516. Sharma, C., Kaur, J., Shishodia, S., Aggarwal, B. B., and Ralhan, R. Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells. Toxicology 11-10-2006;228:1-15. View abstract.
  1517. Zhang, L., Fiala, M., Cashman, J., Sayre, J., Espinosa, A., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G., and Rosenthal, M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2006;10:1-7. View abstract.
  1518. Ganiger, S., Malleshappa, H. N., Krishnappa, H., Rajashekhar, G., Ramakrishna, Rao, V, and Sullivan, F. A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Food Chem.Toxicol 2007;45:64-69. View abstract.
  1519. Ruiz-Torres, M. P., Perez-Rivero, G., Diez-Marques, M. L., Griera, M., Ortega, R., Rodriguez-Puyol, M., and Rodriguez-Puyol, D. Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity. Int.J Biochem.Cell Biol. 2007;39:133-145. View abstract.
  1520. Tonnesen, H. H. Solubility and stability of curcumin in solutions containing alginate and other viscosity modifying macromolecules. Studies of curcumin and curcuminoids. XXX. Pharmazie 2006;61:696-700. View abstract.
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  1522. Zheng, S. and Chen, A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. Am.J Physiol Gastrointest.Liver Physiol 2007;292:G113-G123. View abstract.
  1523. Blasius, R., Reuter, S., Henry, E., Dicato, M., and Diederich, M. Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells. Biochem.Pharmacol 11-30-2006;72:1547-1554. View abstract.
  1524. Thompson, D. A. and Tan, B. B. Tetrahydracurcumin-related allergic contact dermatitis. Contact Dermatitis 2006;55:254-255. View abstract.
  1525. Singh, R. P. and Agarwal, R. Mechanisms of action of novel agents for prostate cancer chemoprevention. Endocr.Relat Cancer 2006;13:751-778. View abstract.
  1526. Magalska, A., Brzezinska, A., Bielak-Zmijewska, A., Piwocka, K., Mosieniak, G., and Sikora, E. Curcumin induces cell death without oligonucleosomal DNA fragmentation in quiescent and proliferating human CD8+ cells. Acta Biochim.Pol. 2006;53:531-538. View abstract.
  1527. Niture, S. K., Velu, C. S., Smith, Q. R., Bhat, G. J., and Srivenugopal, K. S. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 2007;28:378-389. View abstract.
  1528. Karmakar, S., Banik, N. L., Patel, S. J., and Ray, S. K. Curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma T98G cells. Neurosci.Lett. 10-16-2006;407:53-58. View abstract.
  1529. Everett, P. C., Meyers, J. A., Makkinje, A., Rabbi, M., and Lerner, A. Preclinical assessment of curcumin as a potential therapy for B-CLL. Am.J Hematol. 2007;82:23-30. View abstract.
  1530. Weber, W. M., Hunsaker, L. A., Gonzales, A. M., Heynekamp, J. J., Orlando, R. A., Deck, L. M., and Vander Jagt, D. L. TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin. Biochem.Pharmacol 10-16-2006;72:928-940. View abstract.
  1531. Ganguly, K., Kundu, P., Banerjee, A., Reiter, R. J., and Swarnakar, S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radic.Biol.Med. 9-15-2006;41:911-925. View abstract.
  1532. Jung, K. K., Lee, H. S., Cho, J. Y., Shin, W. C., Rhee, M. H., Kim, T. G., Kang, J. H., Kim, S. H., Hong, S., and Kang, S. Y. Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 10-19-2006;79:2022-2031. View abstract.
  1533. Krejsgaard, T., Vetter-Kauczok, C. S., Woetmann, A., Lovato, P., Labuda, T., Eriksen, K. W., Zhang, Q., Becker, J. C., and Odum, N. Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma. Leukemia 2006;20:1759-1766. View abstract.
  1534. Qin, N. Y., Yang, F. Q., Wang, Y. T., and Li, S. P. Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. J Pharm Biomed.Anal. 1-17-2007;43:486-492. View abstract.
  1535. Chan, W. H. and Wu, H. J. Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Acta Pharmacol Sin. 2006;27:1192-1198. View abstract.
  1536. Rahman, I., Biswas, S. K., and Kirkham, P. A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem.Pharmacol 11-30-2006;72:1439-1452. View abstract.
  1537. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on lipid peroxidation and lipids in streptozotocin-nicotinamide-induced diabetic rats. Basic Clin Pharmacol Toxicol 2006;99:122-127. View abstract.
  1538. Rajeswari, A. Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Eur.Rev.Med.Pharmacol Sci. 2006;10:157-161. View abstract.
  1539. Ramassamy, C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur.J Pharmacol 9-1-2006;545:51-64. View abstract.
  1540. Uno, J. K., Kolek, O. I., Hines, E. R., Xu, H., Timmermann, B. N., Kiela, P. R., and Ghishan, F. K. The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis. Gastroenterology 2006;131:497-509. View abstract.
  1541. Choi, H., Chun, Y. S., Kim, S. W., Kim, M. S., and Park, J. W. Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol.Pharmacol 2006;70:1664-1671. View abstract.
  1542. Chowdhury, P., Sacks, S. H., and Sheerin, N. S. Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products. Clin Exp.Immunol. 2006;145:346-356. View abstract.
  1543. Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P., and Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp.Immunol. 2006;145:313-321. View abstract.
  1544. Mosieniak, G., Sliwinska, M., Piwocka, K., and Sikora, E. Curcumin abolishes apoptosis resistance of calcitriol-differentiated HL-60 cells. FEBS Lett. 8-21-2006;580:4653-4660. View abstract.
  1545. Ng, T. P., Chiam, P. C., Lee, T., Chua, H. C., Lim, L., and Kua, E. H. Curry consumption and cognitive function in the elderly. Am.J Epidemiol. 11-1-2006;164:898-906. View abstract.
  1546. Zhang, M., Deng, C. S., Zheng, J. J., and Xia, J. Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis. Acta Pharmacol Sin. 2006;27:1071-1077. View abstract.
  1547. Wu, Q., Chen, Y., and Li, X. HDAC1 expression and effect of curcumin on proliferation of Raji cells. J Huazhong.Univ Sci.Technolog.Med.Sci. 2006;26:199-201, 210. View abstract.
  1548. Wolanin, K., Magalska, A., Mosieniak, G., Klinger, R., McKenna, S., Vejda, S., Sikora, E., and Piwocka, K. Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells. Mol.Cancer Res 2006;4:457-469. View abstract.
  1549. Farhangkhoee, H., Khan, Z. A., Chen, S., and Chakrabarti, S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr.Metab (Lond) 2006;3:27. View abstract.
  1550. Zhou, G., Niu, J. Z., Wang, J. F., Chen, W. T., Liu, T. X., Li, Y. S., and Li, Z. H. [Experimental study on effect of curcumin on inhibiting injury of free radical in pulmonary fibrosis rats]. Zhongguo Zhong.Yao Za Zhi. 2006;31:669-672. View abstract.
  1551. Wu, R., Cui, X., Dong, W., Zhou, M., Simms, H. H., and Wang, P. Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines. Int.J Mol.Med. 2006;18:339-346. View abstract.
  1552. Cui, S. X., Qu, X. J., Xie, Y. Y., Zhou, L., Nakata, M., Makuuchi, M., and Tang, W. Curcumin inhibits telomerase activity in human cancer cell lines. Int.J Mol.Med. 2006;18:227-231. View abstract.
  1553. Vemula, P. K., Li, J., and John, G. Enzyme catalysis: tool to make and break amygdalin hydrogelators from renewable resources: a delivery model for hydrophobic drugs. J Am.Chem.Soc. 7-12-2006;128:8932-8938. View abstract.
  1554. Naganuma, M., Saruwatari, A., Okamura, S., and Tamura, H. Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. Biol.Pharm Bull. 2006;29:1476-1479. View abstract.
  1555. Moon, D. O., Jin, C. Y., Lee, J. D., Choi, Y. H., Ahn, S. C., Lee, C. M., Jeong, S. C., Park, Y. M., and Kim, G. Y. Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets. Biol.Pharm Bull. 2006;29:1470-1475. View abstract.
  1556. Farombi, E. O. and Ekor, M. Curcumin attenuates gentamicin-induced renal oxidative damage in rats. Food Chem.Toxicol 2006;44:1443-1448. View abstract.
  1557. Jackson, J. K., Higo, T., Hunter, W. L., and Burt, H. M. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm.Res 2006;55:168-175. View abstract.
  1558. Eybl, V., Kotyzova, D., and Koutensky, J. Comparative study of natural antioxidants - curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice. Toxicology 8-15-2006;225(2-3):150-156. View abstract.
  1559. Murugan, P. and Pari, L. Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci. 9-27-2006;79:1720-1728. View abstract.
  1560. Mori, Y., Tatematsu, K., Koide, A., Sugie, S., Tanaka, T., and Mori, H. Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats. Cancer Sci. 2006;97:896-904. View abstract.
  1561. Jiang, H., Deng, C. S., Zhang, M., and Xia, J. Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2. World J Gastroenterol. 6-28-2006;12:3848-3853. View abstract.
  1562. Ali, R. E. and Rattan, S. I. Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. Ann.N.Y Acad.Sci. 2006;1067:394-399. View abstract.
  1563. Bala, K., Tripathy, B. C., and Sharma, D. Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions. Biogerontology. 2006;7:81-89. View abstract.
  1564. Zheng, L. D., Tong, Q. S., and Wu, C. H. Growth inhibition and apoptosis inducing mechanisms of curcumin on human ovarian cancer cell line A2780. Chin J Integr.Med. 2006;12:126-131. View abstract.
  1565. Marcu, M. G., Jung, Y. J., Lee, S., Chung, E. J., Lee, M. J., Trepel, J., and Neckers, L. Curcumin is an inhibitor of p300 histone acetylatransferase. Med.Chem. 2006;2:169-174. View abstract.
  1566. Tohda, C., Nakayama, N., Hatanaka, F., and Komatsu, K. Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. Evid.Based.Complement Alternat.Med. 2006;3:255-260. View abstract.
  1567. Zhang, M., Deng, C., Zheng, J., Xia, J., and Sheng, D. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. Int.Immunopharmacol. 2006;6:1233-1242. View abstract.
  1568. Jain, S. K., Rains, J., and Jones, K. Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. Free Radic.Biol.Med. 7-1-2006;41:92-96. View abstract.
  1569. Zhou, G., Wang, J. F., Niu, J. Z., Lu, Y. S., Chen, W. T., Li, Z. H., and Lin, T. X. [Experimental study on protective effects of curcumin on exaggerated extracellular matrix accumulation of pulmonary fibrosis rats]. Zhongguo Zhong.Yao Za Zhi. 2006;31:570-573. View abstract.
  1570. Parodi, F. E., Mao, D., Ennis, T. L., Pagano, M. B., and Thompson, R. W. Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms. Ann.Vasc.Surg. 2006;20:360-368. View abstract.
  1571. Belkaid, A., Copland, I. B., Massillon, D., and Annabi, B. Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin. FEBS Lett. 6-26-2006;580:3746-3752. View abstract.
  1572. Ndamukong, K. J., Ntonifor, N. N., Mbuh, J., Atemnkeng, A. F., and Akam, M. T. Molluscicidal activity of some Cameroonian plants on Bulinus species. East Afr.Med.J 2006;83:102-109. View abstract.
  1573. Al Omar, F. A., Nagi, M. N., Abdulgadir, M. M., Al Joni, K. S., and Al Majed, A. A. Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus. Neurochem.Res 2006;31:611-618. View abstract.
  1574. Panchatcharam, M., Miriyala, S., Gayathri, V. S., and Suguna, L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol.Cell Biochem. 2006;290(1-2):87-96. View abstract.
  1575. Nieman, D. C. and Bishop, N. C. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. J Sports Sci. 2006;24:763-772. View abstract.
  1576. Okunieff, P., Xu, J., Hu, D., Liu, W., Zhang, L., Morrow, G., Pentland, A., Ryan, J. L., and Ding, I. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int.J Radiat.Oncol.Biol.Phys. 7-1-2006;65:890-898. View abstract.
  1577. Lev-Ari, S., Maimon, Y., Strier, L., Kazanov, D., and Arber, N. Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. J Soc.Integr.Oncol. 2006;4:21-26. View abstract.
  1578. He, Y. J., Shu, J. C., Lu, X., Fang, L., and Sheng, Y. [Prophylactic effect of curcumin on hepatic fibrosis and its relationship with activated hepatic stellate cells]. Zhonghua Gan Zang.Bing.Za Zhi. 2006;14:337-340. View abstract.
  1579. Jankun, J., Aleem, A. M., Malgorzewicz, S., Szkudlarek, M., Zavodszky, M. I., Dewitt, D. L., Feig, M., Selman, S. H., and Skrzypczak-Jankun, E. Synthetic curcuminoids modulate the arachidonic acid metabolism of human platelet 12-lipoxygenase and reduce sprout formation of human endothelial cells. Mol.Cancer Ther. 2006;5:1371-1382. View abstract.
  1580. Wu, L. X., Xu, J. H., Huang, X. W., Zhang, K. Z., Wen, C. X., and Chen, Y. Z. Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90. Acta Pharmacol Sin. 2006;27:694-699. View abstract.
  1581. Liu, Y. and Hong, X. Q. [Effect of three different curcumin pigmens on the prdiferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R]. Zhongguo Zhong.Yao Za Zhi. 2006;31:500-503. View abstract.
  1582. Magalska, A., Sliwinska, M., Szczepanowska, J., Salvioli, S., Franceschi, C., and Sikora, E. Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe. Int.J Cancer 10-15-2006;119:1811-1818. View abstract.
  1583. Durham, W. J., Arbogast, S., Gerken, E., Li, Y. P., and Reid, M. B. Progressive nuclear factor-kappaB activation resistant to inhibition by contraction and curcumin in mdx mice. Muscle Nerve 2006;34:298-303. View abstract.
  1584. Siddiqui, A. M., Cui, X., Wu, R., Dong, W., Zhou, M., Hu, M., Simms, H. H., and Wang, P. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med. 2006;34:1874-1882. View abstract.
  1585. Peschel, D., Koerting, R., and Nass, N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr.Biochem. 2007;18:113-119. View abstract.
  1586. Singh, S. and Khar, A. Biological effects of curcumin and its role in cancer chemoprevention and therapy. Anticancer Agents Med.Chem. 2006;6:259-270. View abstract.
  1587. Atsumi, T., Tonosaki, K., and Fujisawa, S. Induction of early apoptosis and ROS-generation activity in human gingival fibroblasts (HGF) and human submandibular gland carcinoma (HSG) cells treated with curcumin. Arch.Oral Biol. 2006;51:913-921. View abstract.
  1588. Lu, P., Tong, Q., Jiang, F., Zheng, L., Chen, F., Zeng, F., Dong, J., and Du, Y. Preparation of curcumin prodrugs and their in vitro anti-tumor activities. J Huazhong.Univ Sci.Technolog.Med.Sci. 2005;25:668-70, 678. View abstract.
  1589. Vanisree, A. J. and Sudha, N. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. Mol.Cell Biochem. 2006;288(1-2):115-123. View abstract.
  1590. Li, X. G., Chen, Y., Wu, Q., and Sun, C. Y. [Effect of curcumin on acetylation of histone H3 in human lymphoma cell line Raji]. Ai.Zheng. 2006;25:582-586. View abstract.
  1591. Melnick, S. J. Developmental therapeutics: review of biologically based CAM therapies for potential application in children with cancer: part I. J Pediatr.Hematol.Oncol. 2006;28:221-230. View abstract.
  1592. Youn, H. S., Saitoh, S. I., Miyake, K., and Hwang, D. H. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem.Pharmacol 6-28-2006;72:62-69. View abstract.
  1593. Perez-Arriaga, L., Mendoza-Magana, M. L., Cortes-Zarate, R., Corona-Rivera, A., Bobadilla-Morales, L., Troyo-Sanroman, R., and Ramirez-Herrera, M. A. Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop. 2006;98:152-161. View abstract.
  1594. Scapagnini, G., Colombrita, C., Amadio, M., D'Agata, V., Arcelli, E., Sapienza, M., Quattrone, A., and Calabrese, V. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid.Redox.Signal. 2006;8(3-4):395-403. View abstract.
  1595. Yuan, G., Wahlqvist, M. L., He, G., Yang, M., and Li, D. Natural products and anti-inflammatory activity. Asia Pac.J Clin Nutr. 2006;15:143-152. View abstract.
  1596. Xia, X., Pan, Y., Zhang, W. Y., Cheng, G., and Kong, L. D. Ethanolic extracts from Curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model. Biol.Pharm Bull. 2006;29:938-944. View abstract.
  1597. Sikora, E., Bielak-Zmijewska, A., Magalska, A., Piwocka, K., Mosieniak, G., Kalinowska, M., Widlak, P., Cymerman, I. A., and Bujnicki, J. M. Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells. Mol.Cancer Ther. 2006;5:927-934. View abstract.
  1598. Liu, H., Danthi, S. J., and Enyeart, J. J. Curcumin potently blocks Kv1.4 potassium channels. Biochem.Biophys.Res Commun. 6-16-2006;344:1161-1165. View abstract.
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  1626. Kwak, H. J., Park, M. J., Cho, H., Park, C. M., Moon, S. I., Lee, H. C., Park, I. C., Kim, M. S., Rhee, C. H., and Hong, S. I. Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells. Mol.Cancer Res 2006;4:209-220. View abstract.
  1627. Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., and Brenner, D. E. Dose escalation of a curcuminoid formulation. BMC.Complement Altern.Med. 2006;6:10. View abstract.
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  1633. Du, Z. Y., Bao, Y. D., Liu, Z., Qiao, W., Ma, L., Huang, Z. S., Gu, L. Q., and Chan, A. S. Curcumin analogs as potent aldose reductase inhibitors. Arch.Pharm (Weinheim) 2006;339:123-128. View abstract.
  1634. Divya, C. S. and Pillai, M. R. Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol.Carcinog. 2006;45:320-332. View abstract.
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  1638. Dikshit, P., Goswami, A., Mishra, A., Nukina, N., and Jana, N. R. Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction. Biochem.Biophys.Res Commun. 4-21-2006;342:1323-1328. View abstract.
  1639. Shapiro, H., Ashkenazi, M., Weizman, N., Shahmurov, M., Aeed, H., and Bruck, R. Curcumin ameliorates acute thioacetamide-induced hepatotoxicity. J Gastroenterol.Hepatol. 2006;21:358-366. View abstract.
  1640. Kukongviriyapan, V., Phromsopha, N., Tassaneeyakul, W., Kukongviriyapan, U., Sripa, B., Hahnvajanawong, V., and Bhudhisawasdi, V. Inhibitory effects of polyphenolic compounds on human arylamine N-acetyltransferase 1 and 2. Xenobiotica 2006;36:15-28. View abstract.
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  1642. Hussain, A. R., Al Rasheed, M., Manogaran, P. S., Al Hussein, K. A., Platanias, L. C., Al Kuraya, K., and Uddin, S. Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. Apoptosis. 2006;11:245-254. View abstract.
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  1644. Moussavi, M., Assi, K., Gomez-Munoz, A., and Salh, B. Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. Carcinogenesis 2006;27:1636-1644. View abstract.
  1645. Collett, G. P. and Campbell, F. C. Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells. Carcinogenesis 2006;27:1285-1291. View abstract.
  1646. McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., and Wigmore, S. J. Curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury. Transplantation 2-27-2006;81:623-626. View abstract.
  1647. Atamna, H. and Boyle, K. Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. Proc.Natl.Acad.Sci.U.S A 2-28-2006;103:3381-3386. View abstract.
  1648. Anuchapreeda, S., Limtrakul, P., Thanarattanakorn, P., Sittipreechacharn, S., and Chanarat, P. Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells. Arch.Pharm Res 2006;29:80-87. View abstract.
  1649. Jiang, H., Timmermann, B. N., and Gang, D. R. Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome. J Chromatogr.A 4-7-2006;1111:21-31. View abstract.
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  1651. Schallreuter, K. U. and Rokos, H. Turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in Asian patients with acute vitiligo. Indian J Dermatol.Venereol.Leprol. 2006;72:57-59. View abstract.
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  1653. Sreepriya, M. and Bali, G. Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol.Cell Biochem. 2006;284(1-2):49-55. View abstract.
  1654. Notoya, M., Nishimura, H., Woo, J. T., Nagai, K., Ishihara, Y., and Hagiwara, H. Curcumin inhibits the proliferation and mineralization of cultured osteoblasts. Eur.J Pharmacol 3-18-2006;534(1-3):55-62. View abstract.
  1655. Lu, M., Leng, Q., Egan, M. E., Caplan, M. J., Boulpaep, E. L., Giebisch, G. H., and Hebert, S. C. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 2006;116:797-807. View abstract.
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  1659. Zhou, H., Wong, Y. F., Cai, X., Liu, Z. Q., Jiang, Z. H., Bian, Z. X., Xu, H. X., and Liu, L. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. Biol.Pharm Bull. 2006;29:253-260. View abstract.
  1660. Kuwabara, N., Tamada, S., Iwai, T., Teramoto, K., Kaneda, N., Yukimura, T., Nakatani, T., and Miura, K. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 2006;67:440-446. View abstract.
  1661. Patel, H. J., Su, S. H., Patterson, C., and Nguyen, K. T. A combined strategy to reduce restenosis for vascular tissue engineering applications. Biotechnol.Prog. 2006;22:38-44. View abstract.
  1662. Hoehle, S. I., Pfeiffer, E., Solyom, A. M., and Metzler, M. Metabolism of curcuminoids in tissue slices and subcellular fractions from rat liver. J Agric.Food Chem. 2-8-2006;54:756-764. View abstract.
  1663. Chakraborty, S., Ghosh, U., Bhattacharyya, N. P., Bhattacharya, R. K., and Roy, M. Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells. Mutat.Res 4-11-2006;596(1-2):81-90. View abstract.
  1664. Chen, W. H., Chen, Y., and Cui, G. H. Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells. Chin Med.J (Engl) 12-20-2005;118:2052-2057. View abstract.
  1665. Pari, L. and Murugan, P. Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats. J Basic Clin Physiol Pharmacol 2005;16:257-274. View abstract.
  1666. Murakami, A., Ishida, H., Kobo, K., Furukawa, I., Ikeda, Y., Yonaha, M., Aniya, Y., and Ohigashi, H. Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammation-associated carcinogenesis. Asian Pac.J Cancer Prev. 2005;6:437-448. View abstract.
  1667. El Ashmawy, I. M., Ashry, K. M., El Nahas, A. F., and Salama, O. M. Protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice. Basic Clin Pharmacol Toxicol 2006;98:32-37. View abstract.
  1668. Fujisawa, S. and Kadoma, Y. Anti- and pro-oxidant effects of oxidized quercetin, curcumin or curcumin-related compounds with thiols or ascorbate as measured by the induction period method. In Vivo 2006;20:39-44. View abstract.
  1669. Shen, G., Xu, C., Hu, R., Jain, M. R., Gopalkrishnan, A., Nair, S., Huang, M. T., Chan, J. Y., and Kong, A. N. Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin. Mol.Cancer Ther. 2006;5:39-51. View abstract.
  1670. Lipecka, J., Norez, C., Bensalem, N., Baudouin-Legros, M., Planelles, G., Becq, F., Edelman, A., and Davezac, N. Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network. J Pharmacol Exp.Ther. 2006;317:500-505. View abstract.
  1671. Khor, T. O., Keum, Y. S., Lin, W., Kim, J. H., Hu, R., Shen, G., Xu, C., Gopalakrishnan, A., Reddy, B., Zheng, X., Conney, A. H., and Kong, A. N. Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice. Cancer Res 1-15-2006;66:613-621. View abstract.
  1672. Barta, I., Smerak, P., Polivkova, Z., Sestakova, H., Langova, M., Turek, B., and Bartova, J. Current trends and perspectives in nutrition and cancer prevention. Neoplasma 2006;53:19-25. View abstract.
  1673. Gulcubuk, A., Altunatmaz, K., Sonmez, K., Haktanir-Yatkin, D., Uzun, H., Gurel, A., and Aydin, S. Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. J Vet.Med.A Physiol Pathol.Clin Med. 2006;53:49-54. View abstract.
  1674. Wootton, L. L. and Michelangeli, F. The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. J Biol.Chem. 3-17-2006;281:6970-6976. View abstract.
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  1676. Fan, C., Wo, X., Qian, Y., Yin, J., and Gao, L. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol. 4-21-2006;105(1-2):251-254. View abstract.
  1677. Frank, B. and Gupta, S. A review of antioxidants and Alzheimer's disease. Ann.Clin Psychiatry 2005;17:269-286. View abstract.
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  1680. Olszanecki, R., Jawien, J., Gajda, M., Mateuszuk, L., Gebska, A., Korabiowska, M., Chlopicki, S., and Korbut, R. Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice. J Physiol Pharmacol 2005;56:627-635. View abstract.
  1681. Hong, J. H., Ahn, K. S., Bae, E., Jeon, S. S., and Choi, H. Y. The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic.Dis. 2006;9:147-152. View abstract.
  1682. Bengmark, S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter.Enteral Nutr. 2006;30:45-51. View abstract.
  1683. Kulkarni, A. P., Ghebremariam, Y. T., and Kotwal, G. J. Curcumin inhibits the classical and the alternate pathways of complement activation. Ann.N.Y Acad.Sci. 2005;1056:100-112. View abstract.
  1684. Tunstall, R. G., Sharma, R. A., Perkins, S., Sale, S., Singh, R., Farmer, P. B., Steward, W. P., and Gescher, A. J. Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: modification by dietary curcumin and implications for clinical trials. Eur.J Cancer 2006;42:415-421. View abstract.
  1685. Du, Z. Y., Liu, R. R., Shao, W. Y., Mao, X. P., Ma, L., Gu, L. Q., Huang, Z. S., and Chan, A. S. Alpha-glucosidase inhibition of natural curcuminoids and curcumin analogs. Eur.J Med.Chem. 2006;41:213-218. View abstract.
  1686. Bernt, C., Vennegeerts, T., Beuers, U., and Rust, C. The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. Biochem.Biophys.Res Commun. 2-17-2006;340:800-806. View abstract.
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  1688. Cho, M. L., Jung, Y. O., Moon, Y. M., Min, S. Y., Yoon, C. H., Lee, S. H., Park, S. H., Cho, C. S., Jue, D. M., and Kim, H. Y. Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways. Immunol.Lett. 3-15-2006;103:159-166. View abstract.
  1689. Gupta, S. and Ravishankar, S. A comparison of the antimicrobial activity of garlic, ginger, carrot, and turmeric pastes against Escherichia coli O157:H7 in laboratory buffer and ground beef. Foodborne.Pathog.Dis. 2005;2:330-340. View abstract.
  1690. Wu, A., Ying, Z., and Gomez-Pinilla, F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp.Neurol. 2006;197:309-317. View abstract.
  1691. Rajasingh, J., Raikwar, H. P., Muthian, G., Johnson, C., and Bright, J. J. Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia. Biochem.Biophys.Res Commun. 2-10-2006;340:359-368. View abstract.
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  1696. Lee, K. W., Kim, J. H., Lee, H. J., and Surh, Y. J. Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells. Antioxid.Redox.Signal. 2005;7(11-12):1612-1620. View abstract.
  1697. Andreadi, C. K., Howells, L. M., Atherfold, P. A., and Manson, M. M. Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol.Pharmacol 2006;69:1033-1040. View abstract.
  1698. Eybl, V., Kotyzova, D., Leseticky, L., Bludovska, M., and Koutensky, J. The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice. J Appl.Toxicol 2006;26:207-212. View abstract.
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  1700. Weber, W. M., Hunsaker, L. A., Roybal, C. N., Bobrovnikova-Marjon, E. V., Abcouwer, S. F., Royer, R. E., Deck, L. M., and Vander Jagt, D. L. Activation of NFkappaB is inhibited by curcumin and related enones. Bioorg.Med.Chem. 4-1-2006;14:2450-2461. View abstract.
  1701. Weber-Mzell, D., Zaupa, P., Petnehazy, T., Kobayashi, H., Schimpl, G., Feierl, G., Kotanko, P., and Hollwarth, M. The role of nuclear factor-kappa B in bacterial translocation in cholestatic rats. Pediatr.Surg.Int. 2006;22:43-49. View abstract.
  1702. Kim, D. C., Kim, S. H., Choi, B. H., Baek, N. I., Kim, D., Kim, M. J., and Kim, K. T. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol.Pharm Bull. 2005;28:2220-2224. View abstract.
  1703. Cai, Y. Z., Mei, Sun, Jie, Xing, Luo, Q., and Corke, H. Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Sci. 5-15-2006;78:2872-2888. View abstract.
  1704. Shakibaei, M., Schulze-Tanzil, G., John, T., and Mobasheri, A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann.Anat. 2005;187(5-6):487-497. View abstract.
  1705. Liu, A., Lou, H., Zhao, L., and Fan, P. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed.Anal. 2-24-2006;40:720-727. View abstract.
  1706. Yang, C., Wang, Z. G., Chen, L. Y., Zhou, J., Zhu, P. F., and Jiang, J. X. Silencing effect of recombinant plasmids PPARgamma-pSUPER-EGFP on the expression of peroxisome proliferator-activated receptor gamma. Chin J Traumatol. 2005;8:352-357. View abstract.
  1707. Kumar, P. A., Haseeb, A., Suryanarayana, P., Ehtesham, N. Z., and Reddy, G. B. Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat. Arch.Biochem.Biophys. 12-15-2005;444:77-83. View abstract.
  1708. Atsumi, T., Murakami, Y., Shibuya, K., Tonosaki, K., and Fujisawa, S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol. Anticancer Res 2005;25(6B):4029-4036. View abstract.
  1709. Zheng, S. and Chen, A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am.J Physiol Gastrointest.Liver Physiol 2006;290:G883-G893. View abstract.
  1710. Song, G., Mao, Y. B., Cai, Q. F., Yao, L. M., Ouyang, G. L., and Bao, S. D. Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression. Braz.J Med.Biol.Res 2005;38:1791-1798. View abstract.
  1711. Thomas, R. K., Sos, M. L., Zander, T., Mani, O., Popov, A., Berenbrinker, D., Smola-Hess, S., Schultze, J. L., and Wolf, J. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Clin Cancer Res 11-15-2005;11:8186-8194. View abstract.
  1712. Zbarsky, V., Datla, K. P., Parkar, S., Rai, D. K., Aruoma, O. I., and Dexter, D. T. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic.Res 2005;39:1119-1125. View abstract.
  1713. Masamune, A., Suzuki, N., Kikuta, K., Satoh, M., Satoh, K., and Shimosegawa, T. Curcumin blocks activation of pancreatic stellate cells. J Cell Biochem. 4-1-2006;97:1080-1093. View abstract.
  1714. Lee, C. W., Lin, W. N., Lin, C. C., Luo, S. F., Wang, J. S., Pouyssegur, J., and Yang, C. M. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation. J Cell Physiol 2006;207:174-186. View abstract.
  1715. Grubb, B. R., Gabriel, S. E., Mengos, A., Gentzsch, M., Randell, S. H., Van Heeckeren, A. M., Knowles, M. R., Drumm, M. L., Riordan, J. R., and Boucher, R. C. SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis. Am.J Respir.Cell Mol.Biol. 2006;34:355-363. View abstract.
  1716. Park, B. S., Kim, J. G., Kim, M. R., Lee, S. E., Takeoka, G. R., Oh, K. B., and Kim, J. H. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric.Food Chem. 11-16-2005;53:9005-9009. View abstract.
  1717. Lee, P. J. An old spice with new twists: curcumin, p38 mitogen-activated protein kinase, and apoptosis. Crit Care Med. 2005;33:2703-2705. View abstract.
  1718. Hu, M., Du, Q., Vancurova, I., Lin, X., Miller, E. J., Simms, H. H., and Wang, P. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med. 2005;33:2571-2578. View abstract.
  1719. Misonou, Y., Asahi, M., Yokoe, S., Miyoshi, E., and Taniguchi, N. Acrolein produces nitric oxide through the elevation of intracellular calcium levels to induce apoptosis in human umbilical vein endothelial cells: implications for smoke angiopathy. Nitric.Oxide. 2006;14:180-187. View abstract.
  1720. Robben, J. H., Sze, M., Knoers, N. V., and Deen, P. M. Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism. Mol.Biol.Cell 2006;17:379-386. View abstract.
  1721. Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., and Matsumoto, K. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci. 3-13-2006;78:1884-1891. View abstract.
  1722. Kempaiah, R. K. and Srinivasan, K. Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr.Biochem. 2006;17:471-478. View abstract.
  1723. D'Incalci, M., Steward, W. P., and Gescher, A. J. Use of cancer chemopreventive phytochemicals as antineoplastic agents. Lancet Oncol. 2005;6:899-904. View abstract.
  1724. Khajavi, M., Inoue, K., Wiszniewski, W., Ohyama, T., Snipes, G. J., and Lupski, J. R. Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants. Am.J Hum.Genet. 2005;77:841-850. View abstract.
  1725. Kim, H., Park, B. S., Lee, K. G., Choi, C. Y., Jang, S. S., Kim, Y. H., and Lee, S. E. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric.Food Chem. 11-2-2005;53:8537-8541. View abstract.
  1726. Aggarwal, B. B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R. A., Bueso-Ramos, C. E., and Price, J. E. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 10-15-2005;11:7490-7498. View abstract.
  1727. Wung, B. S., Hsu, M. C., Wu, C. C., and Hsieh, C. W. Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacol Res 2006;53:113-122. View abstract.
  1728. Holt, P. R., Katz, S., and Kirshoff, R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig.Dis.Sci. 2005;50:2191-2193. View abstract.
  1729. Yang, X., Thomas, D. P., Zhang, X., Culver, B. W., Alexander, B. M., Murdoch, W. J., Rao, M. N., Tulis, D. A., Ren, J., and Sreejayan, N. Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation. Arterioscler.Thromb.Vasc.Biol. 2006;26:85-90. View abstract.
  1730. Yadav, V. S., Mishra, K. P., Singh, D. P., Mehrotra, S., and Singh, V. K. Immunomodulatory effects of curcumin. Immunopharmacol.Immunotoxicol. 2005;27:485-497. View abstract.
  1731. Kaneshiro, T., Suzui, M., Takamatsu, R., Murakami, A., Ohigashi, H., Fujino, T., and Yoshimi, N. Growth inhibitory activities of crude extracts obtained from herbal plants in the Ryukyu Islands on several human colon carcinoma cell lines. Asian Pac.J Cancer Prev. 2005;6:353-358. View abstract.
  1732. Banjerdpongchai, R. and Wilairat, P. Effects of water-soluble antioxidants and MAPKK/MEK inhibitor on curcumin-induced apoptosis in HL-60 human leukemic cells. Asian Pac.J Cancer Prev. 2005;6:282-285. View abstract.
  1733. Tirkey, N., Kaur, G., Vij, G., and Chopra, K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC.Pharmacol 2005;5:15. View abstract.
  1734. Gaedeke, J., Noble, N. A., and Border, W. A. Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1. Kidney Int. 2005;68:2042-2049. View abstract.
  1735. Majithiya, J. B. and Balaraman, R. Time-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcumin. J Cardiovasc.Pharmacol 2005;46:697-705. View abstract.
  1736. Aggarwal, S., Ichikawa, H., Takada, Y., Sandur, S. K., Shishodia, S., and Aggarwal, B. B. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol.Pharmacol 2006;69:195-206. View abstract.
  1737. Ignjacev-Lazich, I., Kintsurashvili, E., Johns, C., Vitseva, O., Duka, A., Shenouda, S., Gavras, I., and Gavras, H. Angiotensin-converting enzyme regulates bradykinin receptor gene expression. Am.J Physiol Heart Circ.Physiol 2005;289:H1814-H1820. View abstract.
  1738. Cao, W. G., Morin, M., Sengers, V., Metz, C., Roger, T., Maheux, R., and Akoum, A. Tumour necrosis factor-alpha up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-kappaB. Hum.Reprod. 2006;21:421-428. View abstract.
  1739. LoTempio, M. M., Veena, M. S., Steele, H. L., Ramamurthy, B., Ramalingam, T. S., Cohen, A. N., Chakrabarti, R., Srivatsan, E. S., and Wang, M. B. Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res 10-1-2005;11(19 Pt 1):6994-7002. View abstract.
  1740. Bemis, D. L., Capodice, J. L., Anastasiadis, A. G., Katz, A. E., and Buttyan, R. Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutr.Cancer 2005;52:202-212. View abstract.
  1741. Polytarchou, C., Hatziapostolou, M., and Papadimitriou, E. Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J Biol.Chem. 12-9-2005;280:40428-40435. View abstract.
  1742. Kim, S. Y., Jung, S. H., and Kim, H. S. Curcumin is a potent broad spectrum inhibitor of matrix metalloproteinase gene expression in human astroglioma cells. Biochem.Biophys.Res Commun. 11-18-2005;337:510-516. View abstract.
  1743. Sun, C., Liu, X., Chen, Y., and Liu, F. Anticancer effect of curcumin on human B cell non-Hodgkin's lymphoma. J Huazhong.Univ Sci.Technolog.Med.Sci. 2005;25:404-407. View abstract.
  1744. Pal, A. and Pal, A. K. Radioprotection of turmeric extracts in bacterial system. Acta Biol.Hung. 2005;56(3-4):333-343. View abstract.
  1745. Nagai, S., Kurimoto, M., Washiyama, K., Hirashima, Y., Kumanishi, T., and Endo, S. Inhibition of cellular proliferation and induction of apoptosis by curcumin in human malignant astrocytoma cell lines. J Neurooncol. 2005;74:105-111. View abstract.
  1746. Azuine, M. A., Kayal, J. J., and Bhide, S. V. Protective role of aqueous turmeric extract against mutagenicity of direct-acting carcinogens as well as benzo [alpha] pyrene-induced genotoxicity and carcinogenicity. J Cancer Res Clin Oncol. 1992;118:447-452. View abstract.
  1747. Pal, S., Bhattacharyya, S., Choudhuri, T., Datta, G. K., Das, T., and Sa, G. Amelioration of immune cell number depletion and potentiation of depressed detoxification system of tumor-bearing mice by curcumin. Cancer Detect.Prev. 2005;29:470-478. View abstract.
  1748. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on erythromycin estolate-induced lipid peroxidation in rats. J Basic Clin Physiol Pharmacol 2005;16:1-15. View abstract.
  1749. Fan, C. L., Qian, Y., Wo, X. D., Yan, J., and Gao, L. P. [Effect of curcumin on the gene expression of low density lipoprotein receptors]. Chin J Integr.Med. 2005;11:201-204. View abstract.
  1750. Kim, K., Ryu, K., Ko, Y., and Park, C. Effects of nuclear factor-kappaB inhibitors and its implication on natural killer T-cell lymphoma cells. Br.J Haematol. 2005;131:59-66. View abstract.
  1751. Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem.Behav. 2005;82:200-206. View abstract.
  1752. Chen, A., Xu, J., and Johnson, A. C. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene 1-12-2006;25:278-287. View abstract.
  1753. Kim, K. J., Yu, H. H., Cha, J. D., Seo, S. J., Choi, N. Y., and You, Y. O. Antibacterial activity of Curcuma longa L. against methicillin-resistant Staphylococcus aureus. Phytother.Res 2005;19:599-604. View abstract.
  1754. Tomita, M., Kawakami, H., Uchihara, J. N., Okudaira, T., Masuda, M., Takasu, N., Matsuda, T., Ohta, T., Tanaka, Y., and Mori, N. Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines. Leuk.Res 2006;30:313-321. View abstract.
  1755. Liu, X. G., Dai, L., Yang, C., Zhao, Z. H., Zhang, X. R., Zhang, Z. G., and Guo, M. Y. Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Chin Med.J (Engl) 8-20-2005;118:1374-1379. View abstract.
  1756. Ono, K., Hirohata, M., and Yamada, M. Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Biochem.Biophys.Res Commun. 10-21-2005;336:444-449. View abstract.
  1757. Nan, B., Yang, H., Yan, S., Lin, P. H., Lumsden, A. B., Yao, Q., and Chen, C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005;138:212-222. View abstract.
  1758. Yoysungnoen, P., Wirachwong, P., Bhattarakosol, P., Niimi, H., and Patumraj, S. Antiangiogenic activity of curcumin in hepatocellular carcinoma cells implanted nude mice. Clin Hemorheol.Microcirc. 2005;33:127-135. View abstract.
  1759. Starr, A. N., Vexler, A., Marmor, S., Konik, D., Ashkenasi-Voghera, M., Lev-Ari, S., Greif, Y., and Ben Yosef, R. Establishment and characterization of a pancreatic carcinoma cell line derived from malignant pleural effusion. Oncology 2005;69:239-245. View abstract.
  1760. Narang, H. and Krishna, M. Inhibition of radiation induced nitration by curcumin and nicotinamide in mouse macrophages. Mol.Cell Biochem. 2005;276(1-2):7-13. View abstract.
  1761. Wu, Q., Chen, Y., and Li, X. G. [Effect of curcumin on caspase 8- and caspase 9- induced apoptosis of lymphoma Raji cell]. Zhongguo Shi Yan.Xue.Ye.Xue.Za Zhi. 2005;13:624-627. View abstract.
  1762. Shen, F., Fan, X., Liu, B., Jia, X., Du, H., You, B., Ye, M., Huang, C., and Shi, X. Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway. Toxicol Lett. 1-25-2006;160:185-195. View abstract.
  1763. Farid, M., Reid, M. B., Li, Y. P., Gerken, E., and Durham, W. J. Effects of dietary curcumin or N-acetylcysteine on NF-kappaB activity and contractile performance in ambulatory and unloaded murine soleus. Nutr.Metab (Lond) 8-26-2005;2:20. View abstract.
  1764. Romero, M. R., Efferth, T., Serrano, M. A., Castano, B., Macias, R. I., Briz, O., and Marin, J. J. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res 2005;68:75-83. View abstract.
  1765. Rukkumani, R., Aruna, K., Varma, P. S., Rajasekaran, K. N., and Menon, V. P. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles. J Med.Food 2005;8:256-260. View abstract.
  1766. Mahesh, T., Balasubashini, M. S., and Menon, V. P. Effect of photo-irradiated curcumin treatment against oxidative stress in streptozotocin-induced diabetic rats. J Med.Food 2005;8:251-255. View abstract.
  1767. Kalpana, C., Rajasekharan, K. N., and Menon, V. P. Modulatory effects of curcumin and curcumin analog on circulatory lipid profiles during nicotine-induced toxicity in Wistar rats. J Med.Food 2005;8:246-250. View abstract.
  1768. Li, X. and Liu, X. Effect of curcumin on immune function of mice. J Huazhong.Univ Sci.Technolog.Med.Sci. 2005;25:137-140. View abstract.
  1769. Huang, M. T., Deschner, E. E., Newmark, H. L., Wang, Z. Y., Ferraro, T. A., and Conney, A. H. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol- induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett. 6-15-1992;64:117-121. View abstract.
  1770. Lee, H. S. Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Bioresour.Technol. 2006;97:1372-1376. View abstract.
  1771. Tomita, M., Kawakami, H., Uchihara, J. N., Okudaira, T., Masuda, M., Takasu, N., Matsuda, T., Ohta, T., Tanaka, Y., Ohshiro, K., and Mori, N. Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int.J Cancer 2-1-2006;118:765-772. View abstract.
  1772. Mutalik, S., Chetana, M., Sulochana, B., Devi, P. U., and Udupa, N. Effect of Dianex, a herbal formulation on experimentally induced diabetes mellitus. Phytother.Res 2005;19:409-415. View abstract.
  1773. Woo, M. S., Jung, S. H., Kim, S. Y., Hyun, J. W., Ko, K. H., Kim, W. K., and Kim, H. S. Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem.Biophys.Res Commun. 10-7-2005;335:1017-1025. View abstract.
  1774. Ramachandran, C., Rodriguez, S., Ramachandran, R., Raveendran Nair, P. K., Fonseca, H., Khatib, Z., Escalon, E., and Melnick, S. J. Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines. Anticancer Res 2005;25:3293-3302. View abstract.
  1775. Li, L., Braiteh, F. S., and Kurzrock, R. Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis. Cancer 9-15-2005;104:1322-1331. View abstract.
  1776. Kumar, P. A., Suryanarayana, P., Reddy, P. Y., and Reddy, G. B. Modulation of alpha-crystallin chaperone activity in diabetic rat lens by curcumin. Mol.Vis. 2005;11:561-568. View abstract.
  1777. Manson, M. M. Inhibition of survival signalling by dietary polyphenols and indole-3-carbinol. Eur.J Cancer 2005;41:1842-1853. View abstract.
  1778. Moon, Y., Glasgow, W. C., and Eling, T. E. Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. J Pharmacol Exp.Ther. 2005;315:788-795. View abstract.
  1779. Sharma, R. A., Gescher, A. J., and Steward, W. P. Curcumin: the story so far. Eur.J Cancer 2005;41:1955-1968. View abstract.
  1780. Suzuki, M., Nakamura, T., Iyoki, S., Fujiwara, A., Watanabe, Y., Mohri, K., Isobe, K., Ono, K., and Yano, S. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol.Pharm Bull. 2005;28:1438-1443. View abstract.
  1781. Matteucci, A., Frank, C., Domenici, M. R., Balduzzi, M., Paradisi, S., Carnovale-Scalzo, G., Scorcia, G., and Malchiodi-Albedi, F. Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca increase. Exp.Brain Res 2005;167:641-648. View abstract.
  1782. Wang, Q., Sun, A. Y., Simonyi, A., Jensen, M. D., Shelat, P. B., Rottinghaus, G. E., MacDonald, R. S., Miller, D. K., Lubahn, D. E., Weisman, G. A., and Sun, G. Y. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci.Res 10-1-2005;82:138-148. View abstract.
  1783. Heath, D. D., Pruitt, M. A., Brenner, D. E., Begum, A. N., Frautschy, S. A., and Rock, C. L. Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 9-25-2005;824(1-2):206-212. View abstract.
  1784. Park, C. H., Lee, J. H., and Yang, C. H. Curcumin derivatives inhibit the formation of Jun-Fos-DNA complex independently of their conserved cysteine residues. J Biochem.Mol.Biol. 7-31-2005;38:474-480. View abstract.
  1785. Goto, H., Sasaki, Y., Fushimi, H., Shibahara, N., Shimada, Y., and Komatsu, K. Effect of curcuma herbs on vasomotion and hemorheology in spontaneously hypertensive rat. Am.J Chin Med. 2005;33:449-457. View abstract.
  1786. Jurrmann, N., Brigelius-Flohe, R., and Bol, G. F. Curcumin blocks interleukin-1 (IL-1) signaling by inhibiting the recruitment of the IL-1 receptor-associated kinase IRAK in murine thymoma EL-4 cells. J Nutr. 2005;135:1859-1864. View abstract.
  1787. Venkatraman, M., Anto, R. J., Nair, A., Varghese, M., and Karunagaran, D. Biological and chemical inhibitors of NF-kappaB sensitize SiHa cells to cisplatin-induced apoptosis. Mol.Carcinog. 2005;44:51-59. View abstract.
  1788. Uddin, S., Hussain, A. R., Manogaran, P. S., Al Hussein, K., Platanias, L. C., Gutierrez, M. I., and Bhatia, K. G. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene 10-27-2005;24:7022-7030. View abstract.
  1789. Osawa, T. and Kato, Y. Protective role of antioxidative food factors in oxidative stress caused by hyperglycemia. Ann.N.Y Acad.Sci. 2005;1043:440-451. View abstract.
  1790. Kim, H. T., Qiang, W., Liu, N., Scofield, V. L., Wong, P. K., and Stoica, G. Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus. J Neurovirol. 2005;11:166-179. View abstract.
  1791. Chakravarty, A. K. and Yasmin, H. Alcoholic turmeric extract simultaneously activating murine lymphocytes and inducing apoptosis of Ehlrich ascitic carcinoma cells. Int.Immunopharmacol. 2005;5:1574-1581. View abstract.
  1792. Shishodia, S., Amin, H. M., Lai, R., and Aggarwal, B. B. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem.Pharmacol 9-1-2005;70:700-713. View abstract.
  1793. Chearwae, W., Wu, C. P., Chu, H. Y., Lee, T. R., Ambudkar, S. V., and Limtrakul, P. Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1). Cancer Chemother.Pharmacol 2006;57:376-388. View abstract.
  1794. Belakavadi, M. and Salimath, B. P. Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase. Mol.Cell Biochem. 2005;273(1-2):57-67. View abstract.
  1795. Ali, B. H., Al Wabel, N., Mahmoud, O., Mousa, H. M., and Hashad, M. Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats. Fundam.Clin Pharmacol 2005;19:473-477. View abstract.
  1796. Sreepriya, M. and Bali, G. Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Fitoterapia 2005;76:549-555. View abstract.
  1797. Lantz, R. C., Chen, G. J., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005;12(6-7):445-452. View abstract.
  1798. Siwak, D. R., Shishodia, S., Aggarwal, B. B., and Kurzrock, R. Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 8-15-2005;104:879-890. View abstract.
  1799. Kumar, R. S., Sivakumar, T., Sunderam, R. S., Gupta, M., Mazumdar, U. K., Gomathi, P., Rajeshwar, Y., Saravanan, S., Kumar, M. S., Murugesh, K., and Kumar, K. A. Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark. Braz.J Med.Biol.Res 2005;38:1015-1024. View abstract.
  1800. Lee, J., Im, Y. H., Jung, H. H., Kim, J. H., Park, J. O., Kim, K., Kim, W. S., Ahn, J. S., Jung, C. W., Park, Y. S., Kang, W. K., and Park, K. Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells. Biochem.Biophys.Res Commun. 8-26-2005;334:313-318. View abstract.
  1801. Strasser, E. M., Wessner, B., Manhart, N., and Roth, E. The relationship between the anti-inflammatory effects of curcumin and cellular glutathione content in myelomonocytic cells. Biochem.Pharmacol 8-15-2005;70:552-559. View abstract.
  1802. Cho, J. W., Park, K., Kweon, G. R., Jang, B. C., Baek, W. K., Suh, M. H., Kim, C. W., Lee, K. S., and Suh, S. I. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp.Mol.Med. 6-30-2005;37:186-192. View abstract.
  1803. Depeille, P., Cuq, P., Passagne, I., Evrard, A., and Vian, L. Combined effects of GSTP1 and MRP1 in melanoma drug resistance. Br.J Cancer 7-25-2005;93:216-223. View abstract.
  1804. Shimizu, M. and Weinstein, I. B. Modulation of signal transduction by tea catechins and related phytochemicals. Mutat.Res 12-11-2005;591(1-2):147-160. View abstract.
  1805. Arafa, H. M. Curcumin attenuates diet-induced hypercholesterolemia in rats. Med.Sci.Monit. 2005;11:BR228-BR234. View abstract.
  1806. Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. The effects of curcumin on depressive-like behaviors in mice. Eur.J Pharmacol 7-25-2005;518:40-46. View abstract.
  1807. Bruzell, E. M., Morisbak, E., and Tonnesen, H. H. Studies on curcumin and curcuminoids. XXIX. Photoinduced cytotoxicity of curcumin in selected aqueous preparations. Photochem.Photobiol.Sci. 2005;4:523-530. View abstract.
  1808. Atsumi, T., Fujisawa, S., and Tonosaki, K. Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells. Oral Dis. 2005;11:236-242. View abstract.
  1809. Wuyts, W. A., Vanaudenaerde, B. M., Dupont, L. J., Van Raemdonck, D. E., Demedts, M. G., and Verleden, G. M. Interleukin-17--induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappaB. J Heart Lung Transplant. 2005;24:875-881. View abstract.
  1810. Gulcubuk, A., Sonmez, K., Gurel, A., Altunatmaz, K., Gurler, N., Aydin, S., Oksuz, L., Uzun, H., and Guzel, O. Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination. Pancreatology. 2005;5(4-5):345-353. View abstract.
  1811. Ringman, J. M., Frautschy, S. A., Cole, G. M., Masterman, D. L., and Cummings, J. L. A potential role of the curry spice curcumin in Alzheimer's disease. Curr.Alzheimer Res 2005;2:131-136. View abstract.
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  1813. Zahid, Ashraf M., Hussain, M. E., and Fahim, M. Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats. Life Sci. 7-8-2005;77:837-857. View abstract.
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  1816. Okazaki, Y., Iqbal, M., and Okada, S. Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate. Biochim.Biophys.Acta 6-10-2005;1740:357-366. View abstract.
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  1819. Kamalakkannan, N., Rukkumani, R., Varma, P. S., Viswanathan, P., Rajasekharan, K. N., and Menon, V. P. Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol 2005;97:15-21. View abstract.
  1820. Ryu, H., Smith, K., Camelo, S. I., Carreras, I., Lee, J., Iglesias, A. H., Dangond, F., Cormier, K. A., Cudkowicz, M. E., Brown, R. H., Jr., and Ferrante, R. J. Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem. 2005;93:1087-1098. View abstract.
  1821. Wessler, S., Muenzner, P., Meyer, T. F., and Naumann, M. The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection. Biol.Chem. 2005;386:481-490. View abstract.
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  1824. Collado, B., Sanchez, M. G., Diaz-Laviada, I., Prieto, J. C., and Carmena, M. J. Vasoactive intestinal peptide (VIP) induces c-fos expression in LNCaP prostate cancer cells through a mechanism that involves Ca2+ signalling. Implications in angiogenesis and neuroendocrine differentiation. Biochim.Biophys.Acta 6-30-2005;1744:224-233. View abstract.
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  2035. Dorai, T., Dutcher, J. P., Dempster, D. W., and Wiernik, P. H. Therapeutic potential of curcumin in prostate cancer--V: Interference with the osteomimetic properties of hormone refractory C4-2B prostate cancer cells. Prostate 6-15-2004;60:1-17. View abstract.
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  2209. Villasenor, I. M., Simon, M. K., and Villanueva, A. M. Comparative potencies of nutraceuticals in chemically induced skin tumor prevention. Nutr.Cancer 2002;44:66-70. View abstract.
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  2219. NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl.Toxicol Program.Tech.Rep.Ser. 1993;427:1-275. View abstract.
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  2223. Huang, C. D., Tliba, O., Panettieri, R. A., Jr., and Amrani, Y. Bradykinin induces interleukin-6 production in human airway smooth muscle cells: modulation by Th2 cytokines and dexamethasone. Am.J Respir.Cell Mol.Biol. 2003;28:330-338. View abstract.
  2224. Deshpande, U. R., Joseph, L. J., Patwardhan, U. N., and Samuel, A. M. Effect of antioxidants (vitamin C, E and turmeric extract) on methimazole induced hypothyroidism in rats. Indian J Exp.Biol. 2002;40:735-738. View abstract.
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  2227. Gaddipati, J. P., Sundar, S. V., Calemine, J., Seth, P., Sidhu, G. S., and Maheshwari, R. K. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock 2003;19:150-156. View abstract.
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  2230. Balogun, E., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J., and Motterlini, R. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem.J 5-1-2003;371(Pt 3):887-895. View abstract.
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  2235. Madan, B. and Ghosh, B. Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock. Shock 2003;19:91-96. View abstract.
  2236. Mahady, G. B., Pendland, S. L., Yun, G., and Lu, Z. Z. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res 2002;22(6C):4179-4181. View abstract.
  2237. Greenwald, P., Milner, J. A., Anderson, D. E., and McDonald, S. S. Micronutrients in cancer chemoprevention. Cancer Metastasis Rev. 2002;21(3-4):217-230. View abstract.
  2238. Devasena, T., Rajasekaran, K. N., Gunasekaran, G., Viswanathan, P., and Menon, V. P. Anticarcinogenic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione a curcumin analog on DMH-induced colon cancer model. Pharmacol.Res. 2003;47:133-140. View abstract.
  2239. Dashwood, R. H. Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. J Biochem.Mol.Biol. 1-31-2003;36:35-42. View abstract.
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  2246. Dickinson, D. A., Iles, K. E., Zhang, H., Blank, V., and Forman, H. J. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J 2003;17:473-475. View abstract.
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  2250. Dorai, T., Gehani, N., and Katz, A. Therapeutic potential of curcumin in human prostate cancer-I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells. Prostate Cancer Prostatic.Dis. 2000;3:84-93. View abstract.
  2251. Gukovsky, I., Reyes, C. N., Vaquero, E. C., Gukovskaya, A. S., and Pandol, S. J. Curcumin ameliorates ethanol and nonethanol experimental pancreatitis. Am.J Physiol Gastrointest.Liver Physiol 2003;284:G85-G95. View abstract.
  2252. Piwocka, K., Bielak-Mijewska, A., and Sikora, E. Curcumin induces caspase-3-independent apoptosis in human multidrug-resistant cells. Ann.N.Y Acad.Sci. 2002;973:250-254. View abstract.
  2253. Mukhopadhyay, A., Banerjee, S., Stafford, L. J., Xia, C., Liu, M., and Aggarwal, B. B. Curcumin-induced suppression of cell proliferation correlates with down-regulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 12-12-2002;21:8852-8861. View abstract.
  2254. Meselhy, M. R. Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry 2003;62:213-218. View abstract.
  2255. Philip, S. and Kundu, G. C. Osteopontin Induces Nuclear Factor kappa B-mediated Promatrix Metalloproteinase-2 Activation through Ikappa Balpha /IKK Signaling Pathways, and Curcumin (Diferulolylmethane) Down-regulates These Pathways. J Biol.Chem. 4-18-2003;278:14487-14497. View abstract.
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  2257. Robinson, T. P., Ehlers, T., Hubbard IV, R. B., Bai, X., Arbiser, J. L., Goldsmith, D. J., and Bowen, J. P. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin. Bioorg.Med.Chem.Lett. 1-6-2003;13:115-117. View abstract.
  2258. Jaiswal, A. S., Marlow, B. P., Gupta, N., and Narayan, S. Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 12-5-2002;21:8414-8427. View abstract.
  2259. Sugimoto, K., Hanai, H., Tozawa, K., Aoshi, T., Uchijima, M., Nagata, T., and Koide, Y. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology 2002;123:1912-1922. View abstract.
  2260. Moga, M. M. Alternative treatment of gallbladder disease. Med.Hypotheses 2003;60:143-147. View abstract.
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  2263. Jayaprakasha, G. K., Jena, B. S., Negi, P. S., and Sakariah, K. K. Evaluation of antioxidant activities and antimutagenicity of turmeric oil: a byproduct from curcumin production. Z.Naturforsch.C. 2002;57(9-10):828-835. View abstract.
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  2265. Yin, K. J., Lee, J. M., Chen, S. D., Xu, J., and Hsu, C. Y. Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells. J Neurosci. 11-15-2002;22:9764-9770. View abstract.
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  2267. Steriti, R. Nutritional support for chronic myelogenous and other leukemias: a review of the scientific literature. Altern.Med.Rev. 2002;7:404-409. View abstract.
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  2269. Bouma, M., Nuijen, B., Jansen, M. T., Sava, G., Bult, A., and Beijnen, J. H. Photostability profiles of the experimental antimetastatic ruthenium complex NAMI-A. J Pharm Biomed.Anal. 11-7-2002;30:1287-1296. View abstract.
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  2272. Bharti, A. C., Donato, N., Singh, S., and Aggarwal, B. B. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2-1-2003;101:1053-1062. View abstract.
  2273. Nanji, A. A., Jokelainen, K., Tipoe, G. L., Rahemtulla, A., Thomas, P., and Dannenberg, A. J. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am.J Physiol Gastrointest.Liver Physiol 2003;284:G321-G327. View abstract.
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  2277. Rinaldi, A. L., Morse, M. A., Fields, H. W., Rothas, D. A., Pei, P., Rodrigo, K. A., Renner, R. J., and Mallery, S. R. Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Cancer Res 10-1-2002;62:5451-5456. View abstract.
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  2285. Molero, L., Garcia-Duran, M., Diaz-Recasens, J., Rico, L., Casado, S., and Lopez-Farre, A. Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen. Cardiovasc.Res 2002;56:43-51. View abstract.
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  2298. Yoshida, S., Kawaguchi, H., Sato, S., Ueda, R., and Furukawa, K. An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. Jpn.J Cancer Res 2002;93:816-824. View abstract.
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  2302. Sawada, H., Ibi, M., Kihara, T., Honda, K., Nakamizo, T., Kanki, R., Nakanishi, M., Sakka, N., Akaike, A., and Shimohama, S. Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model. Neuropharmacology 2002;42:1056-1064. View abstract.
  2303. Galati, G., Sabzevari, O., Wilson, J. X., and O'Brien, P. J. Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 8-1-2002;177:91-104. View abstract.
  2304. Grandjean-Laquerriere, A., Gangloff, S. C., Le Naour, R., Trentesaux, C., Hornebeck, W., and Guenounou, M. Relative contribution of NF-kappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine 5-7-2002;18:168-177. View abstract.
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  2307. Park, M. J., Kim, E. H., Park, I. C., Lee, H. C., Woo, S. H., Lee, J. Y., Hong, Y. J., Rhee, C. H., Choi, S. H., Shim, B. S., Lee, S. H., and Hong, S. I. Curcumin inhibits cell cycle progression of immortalized human umbilical vein endothelial (ECV304) cells by up-regulating cyclin-dependent kinase inhibitor, p21WAF1/CIP1, p27KIP1 and p53. Int.J Oncol. 2002;21:379-383. View abstract.
  2308. Quiles, J. L., Mesa, M. D., Ramirez-Tortosa, C. L., Aguilera, C. M., Battino, M., Gil, A., and Ramirez-Tortosa, M. C. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler.Thromb.Vasc.Biol. 7-1-2002;22:1225-1231. View abstract.
  2309. Li, D., Zimmerman, T. L., Thevananther, S., Lee, H. Y., Kurie, J. M., and Karpen, S. J. Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent. J Biol.Chem. 8-30-2002;277:31416-31422. View abstract.
  2310. Rafiee, P., Shi, Y., Kong, X., Pritchard, K. A., Jr., Tweddell, J. S., Litwin, S. B., Mussatto, K., Jaquiss, R. D., Su, J., and Baker, J. E. Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. Circulation 7-9-2002;106:239-245. View abstract.
  2311. Ramachandran, C., Fonseca, H. B., Jhabvala, P., Escalon, E. A., and Melnick, S. J. Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 10-8-2002;184:1-6. View abstract.
  2312. Somasundaram, S., Edmund, N. A., Moore, D. T., Small, G. W., Shi, Y. Y., and Orlowski, R. Z. Dietary curcumin inhibits chemotherapy-induced apoptosis in models of human breast cancer. Cancer Res 7-1-2002;62:3868-3875. View abstract.
  2313. Reddy, B. S. and Rao, C. V. Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors. J Environ.Pathol.Toxicol Oncol. 2002;21:155-164. View abstract.
  2314. Das, K. C. and Das, C. K. Curcumin (diferuloylmethane), a singlet oxygen (O) quencher. Biochem.Biophys.Res Commun. 7-5-2002;295:62-66. View abstract.
  2315. Fenton, J. I., Wolff, M. S., Orth, M. W., and Hord, N. G. Membrane-type matrix metalloproteinases mediate curcumin-induced cell migration in non-tumorigenic colon epithelial cells differing in Apc genotype. Carcinogenesis 2002;23:1065-1070. View abstract.
  2316. Efferth, T., Davey, M., Olbrich, A., Rucker, G., Gebhart, E., and Davey, R. Activity of drugs from traditional Chinese medicine toward sensitive and. Blood Cells Mol.Dis. 2002;28:160-168. View abstract.
  2317. Holy, J. M. Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cells. Mutat.Res 6-27-2002;518:71-84. View abstract.
  2318. Inano, H. and Onoda, M. Radioprotective action of curcumin extracted from Curcuma longa LINN: inhibitory effect on formation of urinary 8-hydroxy-2'-deoxyguanosine, tumorigenesis, but not mortality, induced by gamma-ray irradiation. Int.J Radiat.Oncol.Biol.Phys. 7-1-2002;53:735-743. View abstract.
  2319. Natarajan, C. and Bright, J. J. Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes. J Immunol. 6-15-2002;168:6506-6513. View abstract.
  2320. Perkins, S., Verschoyle, R. D., Hill, K., Parveen, I., Threadgill, M. D., Sharma, R. A., Williams, M. L., Steward, W. P., and Gescher, A. J. Chemopreventive efficacy and pharmacokinetics of curcumin in the min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol.Biomarkers Prev. 2002;11:535-540. View abstract.
  2321. Toniolo, R., Di Narda, F., Susmel, S., Martelli, M., Martelli, L., and Bontempelli, G. Quenching of superoxide ions by curcumin. A mechanistic study in acetonitrile. Ann.Chim. 2002;92:281-288. View abstract.
  2322. Lukita-Atmadja, W., Ito, Y., Baker, G. L., and McCuskey, R. S. Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin. Shock 2002;17:399-403. View abstract.
  2323. Liacini, A., Sylvester, J., Li, W. Q., and Zafarullah, M. Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes. Matrix Biol. 2002;21:251-262. View abstract.
  2324. Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M., and Cheng, A. L. Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells. Biochem.Pharmacol 5-1-2002;63:1709-1716. View abstract.
  2325. Literat, A., Su, F., Norwicki, M., Durand, M., Ramanathan, R., Jones, C. A., Minoo, P., and Kwong, K. Y. Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life Sci. 12-7-2001;70:253-267. View abstract.
  2326. Bremner, P. and Heinrich, M. Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol 2002;54:453-472. View abstract.
  2327. Dyer, J. L., Khan, S. Z., Bilmen, J. G., Hawtin, S. R., Wheatley, M., Javed, M. U., and Michelangeli, F. Curcumin: a new cell-permeant inhibitor of the inositol 1,4,5-trisphosphate receptor. Cell Calcium 2002;31:45-52. View abstract.
  2328. Tan, Z., Dohi, S., Chen, J., Banno, Y., and Nozawa, Y. Involvement of the mitogen-activated protein kinase family in tetracaine-induced PC12 cell death. Anesthesiology 2002;96:1191-1201. View abstract.
  2329. Hour, T. C., Chen, J., Huang, C. Y., Guan, J. Y., Lu, S. H., and Pu, Y. S. Curcumin enhances cytotoxicity of chemotherapeutic agents in prostate cancer cells by inducing p21(WAF1/CIP1) and C/EBPbeta expressions and suppressing NF-kappaB activation. Prostate 5-15-2002;51:211-218. View abstract.
  2330. Masuda, T., Toi, Y., Bando, H., Maekawa, T., Takeda, Y., and Yamaguchi, H. Structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin. J Agric.Food Chem. 4-24-2002;50:2524-2530. View abstract.
  2331. Aratanechemuge, Y., Komiya, T., Moteki, H., Katsuzaki, H., Imai, K., and Hibasami, H. Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line. Int.J Mol.Med. 2002;9:481-484. View abstract.
  2332. Tripathi, A. K., Prajapati, V., Verma, N., Bahl, J. R., Bansal, R. P., Khanuja, S. P., and Kumar, S. Bioactivities of the leaf essential oil of Curcuma longa (var. ch-66) on three species of stored-product beetles (Coleoptera). J Econ.Entomol. 2002;95:183-189. View abstract.
  2333. Hsu, H. Y. and Wen, M. H. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J Biol.Chem. 6-21-2002;277:22131-22139. View abstract.
  2334. Hu, Y., Du, Q., and Tang, Q. [Determination of chemical constituents of the volatile oil from Curcuma longa by gas chromatography-mass spectrometry]. Se.Pu. 1998;16:528-529. View abstract.
  2335. Patro, B. S., Rele, S., Chintalwar, G. J., Chattopadhyay, S., Adhikari, S., and Mukherjee, T. Protective activities of some phenolic 1,3-diketones against lipid peroxidation: possible involvement of the 1,3-diketone moiety. Chembiochem. 4-2-2002;3:364-370. View abstract.
  2336. Rajakrishnan, V., Shiney, S. J., Sudhakaran, P. R., and Menon, V. P. Effect of curcumin on ethanol-induced stress on mononuclear cells. Phytother.Res 2002;16:171-173. View abstract.
  2337. Saleheen, D., Ali, S. A., Ashfaq, K., Siddiqui, A. A., Agha, A., and Yasinzai, M. M. Latent activity of curcumin against leishmaniasis in vitro. Biol.Pharm Bull. 2002;25:386-389. View abstract.
  2338. Shukla, Y., Arora, A., and Taneja, P. Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats. Mutat.Res 3-25-2002;515(1-2):197-202. View abstract.
  2339. Gescher, A. J., Sharma, R. A., and Steward, W. P. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol. 2001;2:371-379. View abstract.
  2340. Hsu, C. H., Chuang, S. E., Hergenhahn, M., Kuo, M. L., Lin, J. K., Hsieh, C. Y., and Cheng, A. L. Pre-clinical and early-phase clinical studies of curcumin as chemopreventive agent for endemic cancers in Taiwan. Gan To Kagaku Ryoho 2002;29 Suppl 1:194-200. View abstract.
  2341. Kapadia, G. J., Azuine, M. A., Tokuda, H., Hang, E., Mukainaka, T., Nishino, H., and Sridhar, R. Inhibitory effect of herbal remedies on 12-O-tetradecanoylphorbol-13-acetate-promoted Epstein-Barr virus early antigen activation. Pharmacol Res 2002;45:213-220. View abstract.
  2342. Hergenhahn, M., Soto, U., Weninger, A., Polack, A., Hsu, C. H., Cheng, A. L., and Rosl, F. The chemopreventive compound curcumin is an efficient inhibitor of Epstein-Barr virus BZLF1 transcription in Raji DR-LUC cells. Mol.Carcinog. 2002;33:137-145. View abstract.
  2343. Shao, Z. M., Shen, Z. Z., Liu, C. H., Sartippour, M. R., Go, V. L., Heber, D., and Nguyen, M. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. Int.J Cancer 3-10-2002;98:234-240. View abstract.
  2344. Arun, N. and Nalini, N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum.Nutr. 2002;57:41-52. View abstract.
  2345. Scapagnini, G., Foresti, R., Calabrese, V., Giuffrida Stella, A. M., Green, C. J., and Motterlini, R. Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers. Mol.Pharmacol 2002;61:554-561. View abstract.
  2346. Choudhuri, T., Pal, S., Agwarwal, M. L., Das, T., and Sa, G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 2-13-2002;512(1-3):334-340. View abstract.
  2347. Logan-Smith, M. J., East, J. M., and Lee, A. G. Evidence for a global inhibitor-induced conformation change on the Ca-ATPase of sarcoplasmic reticulum from paired inhibitor studies. Biochemistry 2-26-2002;41:2869-2875. View abstract.
  2348. Ikezaki, S., Nishikawa, A., Furukawa, F., Kudo, K., Nakamura, H., Tamura, K., and Mori, H. Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats. Anticancer Res 2001;21:3407-3411. View abstract.
  2349. Sumbilla, C., Lewis, D., Hammerschmidt, T., and Inesi, G. The slippage of the Ca2+ pump and its control by anions and curcumin in skeletal and cardiac sarcoplasmic reticulum. J Biol.Chem. 4-19-2002;277:13900-13906. View abstract.
  2350. Kang, H. C., Nan, J. X., Park, P. H., Kim, J. Y., Lee, S. H., Woo, S. W., Zhao, Y. Z., Park, E. J., and Sohn, D. H. Curcumin inhibits collagen synthesis and hepatic stellate cell activation in-vivo and in-vitro. J Pharm Pharmacol 2002;54:119-126. View abstract.
  2351. Koide, T., Nose, M., Ogihara, Y., Yabu, Y., and Ohta, N. Leishmanicidal effect of curcumin in vitro. Biol.Pharm Bull. 2002;25:131-133. View abstract.
  2352. Ireson, C. R., Jones, D. J., Orr, S., Coughtrie, M. W., Boocock, D. J., Williams, M. L., Farmer, P. B., Steward, W. P., and Gescher, A. J. Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol.Biomarkers Prev. 2002;11:105-111. View abstract.
  2353. Gomez-Lechon, M. J., O'Connor, E., Castell, J. V., and Jover, R. Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes. Toxicol Sci. 2002;65:299-308. View abstract.
  2354. Zhang, H., Yang, L., Liu, S., and Ren, L. [Study on active constituents of traditional Chinese medicine reversing multidrug resistance of tumor cells in vitro]. Zhong.Yao Cai. 2001;24:655-657. View abstract.
  2355. Shin, E. Y., Kim, S. Y., and Kim, E. G. c-Jun N-terminal kinase is involved in motility of endothelial cell. Exp.Mol.Med. 12-31-2001;33:276-283. View abstract.
  2356. Khar, A., Ali, A. M., Pardhasaradhi, B. V., Varalakshmi, C. H., Anjum, R., and Kumari, A. L. Induction of stress response renders human tumor cell lines resistant to curcumin-mediated apoptosis: role of reactive oxygen intermediates. Cell Stress.Chaperones. 2001;6:368-376. View abstract.
  2357. Varadkar, P., Dubey, P., Krishna, M., and Verma, N. Modulation of radiation-induced protein kinase C activity by phenolics. J Radiol.Prot. 2001;21:361-370. View abstract.
  2358. Inano, H. and Onoda, M. Prevention of radiation-induced mammary tumors. Int.J Radiat.Oncol.Biol.Phys. 1-1-2002;52:212-223. View abstract.
  2359. Yan, C., Li, C., and Tian, F. [Fibronectin induces matrix metalloproteinase-2 expression in ovarian cancer cells]. Zhonghua Zhong.Liu Za Zhi. 2000;22:109-112. View abstract.
  2360. Chen, X., He, Q., Liu, W., Xu, Q., Ye, Y., Fu, B., and Yu, L. [AP-1 mediated signal transduction in thrombin-induced regulation of PAL-1 expression in human mesangial cells]. Chin Med.J (Engl) 2000;113:514-519. View abstract.
  2361. Anto, R. J., Mukhopadhyay, A., Denning, K., and Aggarwal, B. B. Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 2002;23:143-150. View abstract.
  2362. Frautschy, S. A., Hu, W., Kim, P., Miller, S. A., Chu, T., Harris-White, M. E., and Cole, G. M. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol.Aging 2001;22:993-1005. View abstract.
  2363. Mukhopadhyay, A., Bueso-Ramos, C., Chatterjee, D., Pantazis, P., and Aggarwal, B. B. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 11-15-2001;20:7597-7609. View abstract.
  2364. Onodera, S., Nishihira, J., Iwabuchi, K., Koyama, Y., Yoshida, K., Tanaka, S., and Minami, A. Macrophage migration inhibitory factor up-regulates matrix metalloproteinase-9 and -13 in rat osteoblasts. Relevance to intracellular signaling pathways. J Biol.Chem. 3-8-2002;277:7865-7874. View abstract.
  2365. Plummer, S. M., Hill, K. A., Festing, M. F., Steward, W. P., Gescher, A. J., and Sharma, R. A. Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. Cancer Epidemiol.Biomarkers Prev. 2001;10:1295-1299. View abstract.
  2366. Wargovich, M. J. Colon cancer chemoprevention with ginseng and other botanicals. J Korean Med.Sci. 2001;16 Suppl:S81-S86. View abstract.
  2367. Kondo, A., Koshihara, Y., and Togari, A. Signal transduction system for interleukin-6 synthesis stimulated by lipopolysaccharide in human osteoblasts. J Interferon Cytokine Res 2001;21:943-950. View abstract.
  2368. Song, E. K., Cho, H., Kim, J. S., Kim, N. Y., An, N. H., Kim, J. A., Lee, S. H., and Kim, Y. C. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med. 2001;67:876-877. View abstract.
  2369. Bilmen, J. G., Khan, S. Z., Javed, M. H., and Michelangeli, F. Inhibition of the SERCA Ca2+ pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP. Eur.J Biochem. 2001;268:6318-6327. View abstract.
  2370. Pollmann, C., Huang, X., Mall, J., Bech-Otschir, D., Naumann, M., and Dubiel, W. The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. Cancer Res 12-1-2001;61:8416-8421. View abstract.
  2371. Bush, J. A., Cheung, K. J., Jr., and Li, G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp.Cell Res 12-10-2001;271:305-314. View abstract.
  2372. Lee, S. E., Campbell, B. C., Molyneux, R. J., Hasegawa, S., and Lee, H. S. Inhibitory effects of naturally occurring compounds on aflatoxin B biotransformation. J Agric.Food Chem. 2001;49:5171-5177. View abstract.
  2373. Cheng, A. L., Hsu, C. H., Lin, J. K., Hsu, M. M., Ho, Y. F., Shen, T. S., Ko, J. Y., Lin, J. T., Lin, B. R., Ming-Shiang, W., Yu, H. S., Jee, S. H., Chen, G. S., Chen, T. M., Chen, C. A., Lai, M. K., Pu, Y. S., Pan, M. H., Wang, Y. J., Tsai, C. C., and Hsieh, C. Y. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001;21(4B):2895-2900. View abstract.
  2374. Phan, T. T., See, P., Lee, S. T., and Chan, S. Y. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma 2001;51:927-931. View abstract.
  2375. Hozumi, A., Nishimura, Y., Nishiuma, T., Kotani, Y., and Yokoyama, M. Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway. Am.J Physiol Lung Cell Mol.Physiol 2001;281:L1444-L1452. View abstract.
  2376. Chang, D. M. Curcumin: a heat shock response inducer and potential cytoprotector. Crit Care Med. 2001;29:2231-2232. View abstract.
  2377. Dunsmore, K. E., Chen, P. G., and Wong, H. R. Curcumin, a medicinal herbal compound capable of inducing the heat shock response. Crit Care Med. 2001;29:2199-2204. View abstract.
  2378. Wargovich, M. J., Woods, C., Hollis, D. M., and Zander, M. E. Herbals, cancer prevention and health. J Nutr. 2001;131(11 Suppl):3034S-3036S. View abstract.
  2379. Asai, A. and Miyazawa, T. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr. 2001;131:2932-2935. View abstract.
  2380. Ichiki, K., Mitani, N., Doki, Y., Hara, H., Misaki, T., and Saiki, I. Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer. Clin Exp.Metastasis 2000;18:539-545. View abstract.
  2381. Batth, B. K., Tripathi, R., and Srinivas, U. K. Curcumin-induced differentiation of mouse embryonal carcinoma PCC4 cells. Differentiation 2001;68(2-3):133-140. View abstract.
  2382. Shih, S. C. and Claffey, K. P. Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression. Growth Factors 2001;19:19-34. View abstract.
  2383. Pal, S., Choudhuri, T., Chattopadhyay, S., Bhattacharya, A., Datta, G. K., Das, T., and Sa, G. Mechanisms of curcumin-induced apoptosis of Ehrlich's ascites carcinoma cells. Biochem.Biophys.Res Commun. 11-2-2001;288:658-665. View abstract.
  2384. Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., and Cole, G. M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci. 11-1-2001;21:8370-8377. View abstract.
  2385. Zhang, W., Liu, D., Wo, X., Zhang, Y., Jin, M., and Ding, Z. Effects of Curcuma Longa on proliferation of cultured bovine smooth muscle cells and on expression of low density lipoprotein receptor in cells. Chin Med.J (Engl) 1999;112:308-311. View abstract.
  2386. Logan-Smith, M. J., Lockyer, P. J., East, J. M., and Lee, A. G. Curcumin, a molecule that inhibits the Ca2+-ATPase of sarcoplasmic reticulum but increases the rate of accumulation of Ca2+. J Biol.Chem. 12-14-2001;276:46905-46911. View abstract.
  2387. Hill-Kapturczak, N., Thamilselvan, V., Liu, F., Nick, H. S., and Agarwal, A. Mechanism of heme oxygenase-1 gene induction by curcumin in human renal proximal tubule cells. Am.J Physiol Renal Physiol 2001;281:F851-F859. View abstract.
  2388. Mendez-Samperio, P., Palma, J., and Vazquez, A. Roles of intracellular calcium and NF-kappaB in the Bacillus Calmette-Guerin-induced secretion of interleukin-8 from human monocytes. Cell Immunol. 8-1-2001;211:113-122. View abstract.
  2389. Kelly, M. R., Xu, J., Alexander, K. E., and Loo, G. Disparate effects of similar phenolic phytochemicals as inhibitors of oxidative damage to cellular DNA. Mutat.Res 5-10-2001;485:309-318. View abstract.
  2390. Goel, A., Boland, C. R., and Chauhan, D. P. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 10-30-2001;172:111-118. View abstract.
  2391. Levi, M. S., Borne, R. F., and Williamson, J. S. A review of cancer chemopreventive agents. Curr.Med.Chem. 2001;8:1349-1362. View abstract.
  2392. Kim, D. S. and Kim, J. Y. Total synthesis of Calebin-A, preparation of its analogues, and their neuronal cell protectivity against beta-amyloid insult. Bioorg.Med.Chem.Lett. 9-17-2001;11:2541-2543. View abstract.
  2393. Sindhwani, P., Hampton, J. A., Baig, M. M., Keck, R., and Selman, S. H. Curcumin prevents intravesical tumor implantation of the MBT-2 tumor cell line in C3H mice. J Urol. 2001;166:1498-1501. View abstract.
  2394. Cipriani, B., Borsellino, G., Knowles, H., Tramonti, D., Cavaliere, F., Bernardi, G., Battistini, L., and Brosnan, C. F. Curcumin inhibits activation of Vgamma9Vdelta2 T cells by phosphoantigens and induces apoptosis involving apoptosis-inducing factor and large scale DNA fragmentation. J Immunol. 9-15-2001;167:3454-3462. View abstract.
  2395. Shahed, A. R., Jones, E., and Shoskes, D. Quercetin and curcumin up-regulate antioxidant gene expression in rat kidney after ureteral obstruction or ischemia/reperfusion injury. Transplant.Proc. 2001;33:2988. View abstract.
  2396. Kim, M. S., Kang, H. J., and Moon, A. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells. Arch.Pharm Res 2001;24:349-354. View abstract.
  2397. Koh, Y. H., Che, W., Higashiyama, S., Takahashi, M., Miyamoto, Y., Suzuki, K., and Taniguchi, N. Osmotic stress induces HB-EGF gene expression via Ca/Pyk2/JNK signal cascades in rat aortic smooth muscle cells. J Biochem. 2001;130:351-358. View abstract.
  2398. Kapoor, S. and Priyadarsini, K. I. Protection of radiation-induced protein damage by curcumin. Biophys.Chem. 8-30-2001;92(1-2):119-126. View abstract.
  2399. Piwocka, K., Jaruga, E., Skierski, J., Gradzka, I., and Sikora, E. Effect of glutathione depletion on caspase-3 independent apoptosis pathway induced by curcumin in Jurkat cells. Free Radic.Biol.Med. 9-1-2001;31:670-678. View abstract.
  2400. Surh, Y. J., Chun, K. S., Cha, H. H., Han, S. S., Keum, Y. S., Park, K. K., and Lee, S. S. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat.Res 9-1-2001;480-481:243-268. View abstract.
  2401. Mori, H., Niwa, K., Zheng, Q., Yamada, Y., Sakata, K., and Yoshimi, N. Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells. Mutat.Res 9-1-2001;480-481:201-207. View abstract.
  2402. Smith, W. A., Freeman, J. W., and Gupta, R. C. Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7. Mutat.Res 9-1-2001;480-481:97-108. View abstract.
  2403. Akrishnan, V. R. and Menon, V. P. Potential role of antioxidants during ethanol-induced changes in the fatty acid composition and arachidonic acid metabolites in male Wistar rats. Cell Biol.Toxicol 2001;17:11-22. View abstract.
  2404. Ahmad-Raus, R. R., Abdul-Latif, E. S., and Mohammad, J. J. Lowering of lipid composition in aorta of guinea pigs by Curcuma domestica. BMC.Complement Altern Med 2001;1:6. View abstract.
  2405. Prucksunand, C., Indrasukhsri, B., Leethochawalit, M., and Hungspreugs, K. Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer. Southeast Asian J Trop Med Public Health 2001;32:208-215. View abstract.
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  2407. Jaga, K. and Duvvi, H. Risk reduction for DDT toxicity and carcinogenesis through dietary modification. J R.Soc.Promot.Health 2001;121:107-113. View abstract.
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  2411. Akhand, A. A., Hossain, K., Mitsui, H., Kato, M., Miyata, T., Inagi, R., Du, J., Takeda, K., Kawamoto, Y., Suzuki, H., Kurokawa, K., and Nakashima, I. Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in human endothelial cells. Free Radic.Biol.Med. 7-1-2001;31:20-30. View abstract.
  2412. Lee, S. K., Kim, B. S., Yang, W. S., Kim, S. B., Park, S. K., and Park, J. S. High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells. Kidney Int. 2001;60:55-64. View abstract.
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  2416. Dorai, T., Cao, Y. C., Dorai, B., Buttyan, R., and Katz, A. E. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 6-1-2001;47:293-303. View abstract.
  2417. Renard, P., Delaive, E., Van Steenbrugge, M., Remacle, J., and Raes, M. Is the effect of interleukin-1 on glutathione oxidation in cultured human fibroblasts involved in nuclear factor-kappaB activation? Antioxid.Redox.Signal. 2001;3:329-340. View abstract.
  2418. Moragoda, L., Jaszewski, R., and Majumdar, A. P. Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. Anticancer Res 2001;21(2A):873-878. View abstract.
  2419. Bian, Z. M., Elner, V. M., Yoshida, A., Kunkel, S. L., and Elner, S. G. Signaling pathways for glycated human serum albumin-induced IL-8 and MCP-1 secretion in human RPE cells. Invest Ophthalmol.Vis.Sci. 2001;42:1660-1668. View abstract.
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  2422. Liu, W. H., Chen, X. M., and Fu, B. Thrombin stimulates MMP-9 mRNA expression through AP-1 pathway in human mesangial cells. Acta Pharmacol Sin. 2000;21:641-645. View abstract.
  2423. Sharma, R. A., Ireson, C. R., Verschoyle, R. D., Hill, K. A., Williams, M. L., Leuratti, C., Manson, M. M., Marnett, L. J., Steward, W. P., and Gescher, A. Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. Clin Cancer Res 2001;7:1452-1458. View abstract.
  2424. Bielak-Zmijewska, A., Koronkiewicz, M., Skierski, J., Piwocka, K., Radziszewska, E., and Sikora, E. Effect of curcumin on the apoptosis of rodent and human nonproliferating and proliferating lymphoid cells. Nutr.Cancer 2000;38:131-138. View abstract.
  2425. Oguro, T. and Yoshida, T. Effect of ultraviolet A on ornithine decarboxylase and metallothionein gene expression in mouse skin. Photodermatol.Photoimmunol.Photomed. 2001;17:71-78. View abstract.
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  2427. Collett, G. P., Robson, C. N., Mathers, J. C., and Campbell, F. C. Curcumin modifies Apc(min) apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apc(min) mice. Carcinogenesis 2001;22:821-825. View abstract.
  2428. Busquets, S., Carbo, N., Almendro, V., Quiles, M. T., Lopez-Soriano, F. J., and Argiles, J. M. Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model. Cancer Lett. 6-10-2001;167:33-38. View abstract.
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  2430. Sood, A., Mathew, R., and Trachtman, H. Cytoprotective effect of curcumin in human proximal tubule epithelial cells exposed to shiga toxin. Biochem.Biophys.Res Commun. 4-27-2001;283:36-41. View abstract.
  2431. Chen, Y. C., Tsai, S. H., Shen, S. C., Lin, J. K., and Lee, W. R. Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. Eur.J Cell Biol. 2001;80:213-221. View abstract.
  2432. Rilantono, L. I., Yuwono, H. S., and Nugrahadi, T. Dietary antioxidative potential in arteries. Clin Hemorheol.Microcirc. 2000;23(2-4):113-117. View abstract.
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  2434. Jayaprakasha, G. K., Negi, P. S., Anandharamakrishnan, C., and Sakariah, K. K. Chemical composition of turmeric oil--a byproduct from turmeric oleoresin industry and its inhibitory activity against different fungi. Z.Naturforsch.C. 2001;56(1-2):40-44. View abstract.
  2435. Kim, D. S., Park, S. Y., and Kim, J. K. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci.Lett. 4-27-2001;303:57-61. View abstract.
  2436. Babu, B. H., Shylesh, B. S., and Padikkala, J. Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 2001;72:272-277. View abstract.
  2437. Bech-Otschir, D., Kraft, R., Huang, X., Henklein, P., Kapelari, B., Pollmann, C., and Dubiel, W. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J 4-2-2001;20:1630-1639. View abstract.
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  2445. Araujo, M. C., Antunes, L. M., and Takahashi, C. S. Protective effect of thiourea, a hydroxyl-radical scavenger, on curcumin-induced chromosomal aberrations in an in vitro mammalian cell system. Teratog.Carcinog.Mutagen. 2001;21:175-180. View abstract.
  2446. Ireson, C., Orr, S., Jones, D. J., Verschoyle, R., Lim, C. K., Luo, J. L., Howells, L., Plummer, S., Jukes, R., Williams, M., Steward, W. P., and Gescher, A. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 2-1-2001;61:1058-1064. View abstract.
  2447. Thapliyal, R., Deshpande, S. S., and Maru, G. B. Effects of turmeric on the activities of benzo(a)pyrene-induced cytochrome P-450 isozymes. J Environ.Pathol.Toxicol Oncol. 2001;20:59-63. View abstract.
  2448. Li, W. Q., Dehnade, F., and Zafarullah, M. Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway. J Immunol. 3-1-2001;166:3491-3498. View abstract.
  2449. Cuendet, M. and Pezzuto, J. M. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention. Drug Metabol.Drug Interact. 2000;17(1-4):109-157. View abstract.
  2450. Kondo, A., Mogi, M., Koshihara, Y., and Togari, A. Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells. Biochem.Pharmacol 2-1-2001;61:319-326. View abstract.
  2451. Xu, K. and Thornalley, P. J. Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukaemia cells in vitro. Biochem.Pharmacol 1-15-2001;61:165-177. View abstract.
  2452. Naganuma, K., Amano, S., Takeda, H., Kitano, S., and Hanazawa, S. Role of transcriptional factor activation protein-1 in endogenous expression of the interleukin-1 beta gene involved in Porphyromonas gingivalis fimbria-stimulated bone resorption in the mouse calvarial system. Oral Microbiol.Immunol. 2000;15:53-57. View abstract.
  2453. Rajakrishnan, V., Jayadeep, A., Arun, O. S., Sudhakaran, P. R., and Menon, V. P. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr.Biochem. 2000;11:509-514. View abstract.
  2454. Pal, A. and Pal, A. K. Studies on the genotoxicity of turmeric extracts in bacterial system. Int.J Antimicrob.Agents 2000;16:415-417. View abstract.
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  2456. Pan, M. H., Lin-Shiau, S. Y., and Lin, J. K. Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages. Biochem.Pharmacol 12-1-2000;60:1665-1676. View abstract.
  2457. Heng, M. C., Song, M. K., Harker, J., and Heng, M. K. Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. Br.J Dermatol. 2000;143:937-949. View abstract.
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  2459. Ishii, H., Takada, K., Higuchi, T., and Sugiyama, J. Verotoxin-1 induces tissue factor expression in human umbilical vein endothelial cells through activation of NF-kappaB/Rel and AP-1. Thromb.Haemost. 2000;84:712-721. View abstract.
  2460. Weigert, C., Sauer, U., Brodbeck, K., Pfeiffer, A., Haring, H. U., and Schleicher, E. D. AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells. J Am.Soc.Nephrol. 2000;11:2007-2016. View abstract.
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  2462. Zhou, A., McFeeters, R. F., and Fleming, H. P. Inhibition of formation of oxidative volatile components in fermented cucumbers by ascorbic acid and turmeric. J Agric.Food Chem. 2000;48:4910-4912. View abstract.
  2463. Ramirez-Bosca, A., Soler, A., Carrion, M. A., Diaz-Alperi, J., Bernd, A., Quintanilla, C., Quintanilla, Almagro E., and Miquel, J. An hydroalcoholic extract of curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention. Mech.Ageing Dev. 10-20-2000;119(1-2):41-47. View abstract.
  2464. Chuang, S. E., Cheng, A. L., Lin, J. K., and Kuo, M. L. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food Chem.Toxicol 2000;38:991-995. View abstract.
  2465. Hossain, K., Akhand, A. A., Kato, M., Du, J., Takeda, K., Wu, J., Takeuchi, K., Liu, W., Suzuki, H., and Nakashima, I. Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. J Immunol. 10-15-2000;165:4290-4297. View abstract.
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  2467. Moreno-Manzano, V., Lucio-Cazana, J., Konta, T., Nakayama, K., and Kitamura, M. Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism. Biochem.Biophys.Res Commun. 10-22-2000;277:293-298. View abstract.
  2468. Skrzypczak-Jankun, E., McCabe, N. P., Selman, S. H., and Jankun, J. Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence. Int.J Mol.Med. 2000;6:521-526. View abstract.
  2469. Inano, H., Onoda, M., Inafuku, N., Kubota, M., Kamada, Y., Osawa, T., Kobayashi, H., and Wakabayashi, K. Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 2000;21:1835-1841. View abstract.
  2470. Matsushita, K., Motani, R., Sakuta, T., Yamaguchi, N., Koga, T., Matsuo, K., Nagaoka, S., Abeyama, K., Maruyama, I., and Torii, M. The role of vascular endothelial growth factor in human dental pulp cells: induction of chemotaxis, proliferation, and differentiation and activation of the AP-1-dependent signaling pathway. J Dent.Res 2000;79:1596-1603. View abstract.
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  2474. Sato, M., Cordis, G. A., Maulik, N., and Das, D. K. SAPKs regulation of ischemic preconditioning. Am.J Physiol Heart Circ.Physiol 2000;279:H901-H907. View abstract.
  2475. Nakano, N., Shirasaka, N., Koyama, H., Hino, M., Murakami, T., Shimizu, S., and Yoshizumi, H. C19 odd-chain polyunsaturated fatty acids (PUfas) are metabolized to C21-PUfas in a rat liver cell line, and curcumin, gallic acid, and their related compounds inhibit their desaturation. Biosci.Biotechnol.Biochem. 2000;64:1641-1650. View abstract.
  2476. Punithavathi, D., Venkatesan, N., and Babu, M. Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br.J Pharmacol 2000;131:169-172. View abstract.
  2477. Tharaux, P. L., Chatziantoniou, C., Fakhouri, F., and Dussaule, J. C. Angiotensin II activates collagen I gene through a mechanism involving the MAP/ER kinase pathway. Hypertension 2000;36:330-336. View abstract.
  2478. Ishikawa, Y. and Kitamura, M. Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. Kidney Int. 2000;58:1078-1087. View abstract.
  2479. Mariadason, J. M., Corner, G. A., and Augenlicht, L. H. Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. Cancer Res 8-15-2000;60:4561-4572. View abstract.
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  2485. Singh, R. and Rai, B. Antifungal potential of some higher plants against Fusarium udum causing wilt disease of Cajanus cajan. Microbios 2000;102:165-173. View abstract.
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  2491. Nishizono, S., Hayami, T., Ikeda, I., and Imaizumi, K. Protection against the diabetogenic effect of feeding tert-butylhydroquinone to rats prior to the administration of streptozotocin. Biosci.Biotechnol.Biochem. 2000;64:1153-1158. View abstract.
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