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L-arginina

¿Qué es?

La L-arginina es un bloque químico fundamental llamado “aminoácido”. Se obtiene a partir de la dieta y es necesaria para el cuerpo para hacer las proteínas. La L-arginina se encuentra en la carne roja, en la carne de aves y los productos lácteos. También se puede hacer en el laboratorio y usar como medicamento.

La L-arginina se utiliza para afecciones del corazón y vasos sanguíneos incluyendo la insuficiencia cardiaca congestiva (CHF), el dolor de pecho, la presión arterial alta y las enfermedades de las arterias coronarias. La L-arginina también se usa para el dolor recurrente en las piernas debido a arterias que están bloqueadas (claudicación intermitente), para el tratamiento de la disminución de la capacidad mental en los ancianos (demencia senil), para la disfunción eréctil (DE) y la infertilidad masculina.

Algunas personas usan la L-arginina para la prevención del resfrío común, para mejorar el funcionamiento de los riñones después de un transplante de riñón, para la presión arterial alta durante el embarazo (preeclampsia), para mejorar el rendimiento atlético, para aumentar el sistema inmunológico y para prevenir la inflamación del tracto digestivo en los infantes prematuros.

La L-arginina se utiliza en combinación con un gran número de medicamentos que se venden con o sin receta médica y que se utilizan para distintas afecciones. Por ejemplo, la L-arginina se usa junto con ibuprofeno para los dolores de cabeza de migraña; junto con los fármacos convencionales que se usan en los tratamientos de quimioterapia para el cáncer de mamas; junto con otros aminoácidos para el tratamiento de la pérdida de peso en los pacientes con SIDA; y junto con aceite de pescado y otros suplementos para disminuir las infecciones, mejorar la cicatrización de las heridas y acortar el tiempo necesario para la recuperación después de una cirugía.

Algunas personas aplican la L-arginina a la piel para acelerar la cicatrización de las heridas y para aumentar el flujo de sangre a las manos y pies helados, especialmente en las personas con diabetes. También se usa como una crema para los problemas sexuales tanto en los hombres como en las mujeres.

¿Qué tan efectivo es?

Natural Medicines Comprehensive Database (La Base Exhaustiva de Datos de Medicamentos Naturales) clasifica la eficacia, basada en evidencia científica, de acuerdo a la siguiente escala: Eficaz, Probablemente Eficaz, Posiblemente Eficaz, Posiblemente Ineficaz, Probablemente Ineficaz, Ineficaz, e Insuficiente Evidencia para Hacer una Determinación.

La clasificación de la eficacia para este producto es la siguiente:

Posiblemente eficaz para...

  • Dolor de pecho (angina). La ingesta de L-arginine parece reducir los síntomas y mejorar la tolerancia al ejercicio físico y la calidad de vida en personas con angina de pecho. Sin embargo, la L-arginina no parece mejorar la enfermedad misma.
  • Disfunción eréctil (DE). La ingesta diaria de 5 gramos de L-arginina parece mejorar la función sexual en hombres con DE. La ingesta de dosis bajas podrían no tener efecto. Sin embargo, existe cierta evidencia que muestra que agregar 40 mg de Pycnogenol tres veces por día podría mejorar la efectividad de la dosis baja de L-arginine para tratar la DE.
  • Hipertensión arterial. Existe cierta evidencia que muestra que la ingesta de L-arginine puede reducir la hipertensión arterial en personas sanas, hipertensas y con presion arterial levemente alta con o sin diabetes.
  • Inflamación de las vías digestivas en bebés prematuros. Agregar L-arginine a la leche maternizada parece prevenir la inflamación de las vías digestivas en bebés prematuros.
  • Intolerancia al nitrato. La ingesta de 700 mg de L-arginine cuatro veces por día parece prevenir la intolerancia al nitrato en personas que toman nitroglicerina ara tratar la angina de pecho.
  • Dolor en las piernas asociado con mala irrigación sanguínea (vasculopatía periférica). La investigación sugiere que la ingesta de L-arginine o por vía intravenosa (VI) durante un máximo de ocho semanas mejora la irrigación sanguínea en personas con vasculopatía periférica. Sin embargo, su uso prolongado (hasta un máximo de seis meses) no mejora los problemas ni la velocidad para caminar en personas con vasculopatía periférica.
  • Mejorar la recuperación después de una cirugía. El tomar L-arginina con ácido ribonucleico (ARN) y ácido eicopentaénoico (EPA) antes o después de una cirugía parece ayudar a disminuir el tiempo de recuperación, disminuir el número de infecciones y mejorar la cicatrización de las heridas después de la cirugía.
  • Hipertensión arterial durante el embarazo (preeclampsia). Aunque son contradictorios los resultados sobre los efectos de la L-arginine para tratar la preeclampsia, la mayoría de la investigación sugiere que puede disminuir la presión arterial en mujeres con esta condición.

Posiblemente ineficaz para...

  • Enfermedad renal. La mayoría de la investigación sugiere que la L-arginine, ya sea ingerida durante un máximo de seis meses o por via intravenosa (VI) durante un breve tiempo, no mejora la función renal en personas con insuficiencia renal o enfermedad renal. Sin embargo, la ingesta de 1,3 gramos de L-arginina parece mejorar la función renal y detener la anemia en personas ancianas con anemia asociada con enfermedad renal.
  • Ataque al corazón. El tomar L-arginina no parece ayudar a prevenir un ataque al corazón. Además, no parece ser beneficioso para el tratamiento del ataque al corazón después que este ya ha ocurrido. De hecho, hay preocupación de que la L-arginina podría producir daño después de un reciente ataque al corazón. No tome L-arginina si ha tenido un ataque al corazón recientemente.
  • Cicatrización de las heridas. La ingesta de L-arginina no parece mejorar la cicatrización de las heridas.

Insuficiente evidencia para hacer una determinación para...

  • Adelgazamiento relacionado con SIDA. La ingesta de L-arginina junto con hidroximetilbutirato (HMB) y glutamina durante ochos semanas parece aumentar el peso corporal y mejorar la función inmunitaria en personas con VIH/SIDA. Sin embargo, la ingesta diaria de 7,4 gramos de L-arginina junto con ácidos grasos omega 3 y un suplemento nutricional equilibrado durante seis meses no mejora el peso corporal o la masa grasa, el aporte energético y la función inmunitaria en personas con VIH positivo.
  • Mal de las alturas. La investigación sugiere que la L-arginina no reduce el mal de las alturas.
  • Fisuras anales. Es contradictoria la evidencia sobre la efectividad de la L-arginina para tratar las fisuras anales. La aplicación de L-arginina en la piel dos veces por día durante tres meses es menos efectiva que la cirugía por fisura anal. Sin embargo, la aplicación de un gel tópico que contiene L-arginina cinco veces por día al menos durante 12 semanas podría curar las fisuras anales en personas que no responden al tratamiento tradicional.
  • Cáncer de mama. La investigación preliminar muestra que la ingesta de L-arginina antes de la quimioterapia no mejora la tasa de respuesta en personas con cáncer de mama.
  • Efectos secundarios de la quimioterapia. La investigación preliminar muestra que la ingesta de L-arginina antes de comenzar la quimioterapia puede prevenir la disminución de la actividad del sistema inmunitario asociada con el tratamiento de quimioterapia en personas con cáncer de mama.
  • Insuficiencia cardíaca congestiva. La ingesta de L-arginina junto con un tratamiento tradicional parce mejorar la función renal n personas con Insuficiencia cardíaca. No obstante podría mejorar la capacidad física, la calidad de vida y la circulación sanguínea. La L-arginina debería usarse con precaución en personas con cirrosis.
  • Obstrucción arterial (arteriopatía coronaria). La investigación preliminar sugiere que la ingesta de L-arginina o por vía intravenosa (VI) antes de realizar actividad física mejora la función arterial en personas con coronaria. Sin embargo, no mejora la irrigación sanguínea al corazón.
  • Enfermedad grave (traumatismo). La investigación muestra que la ingesta de L-arginina con glutamina, nucleótidos y ácidos grasos omega 3 reduce el tiempo de recuperación, la necesidad de ventilación y el riesgo de infecciones en personas con enfermedad grave; sin embargo, no reduce el riesgo de muerte.
  • Pérdida de memoria (demencia). La investigación preliminar sugiere que la L-arginina podría mejorar la pérdida de la memoria relacionada con el envejecimiento.
  • Cavidades bucales. La investigación preliminar sugiere que el uso de menta sin azúcar que contiene un complejo de arginina (CaviStat) durante un año reduce el número de cavidades en molares de niños en comparación con las mentas sin azúcar que no contiene arginina.
  • Dientes sensibles. La investigación preliminar sugiere que el uso de una pasta dental que contiene arginina, calcio y flúor reduce la sensibilidad de los dientes cuando se lo usa dos veces al día.
  • Diabetes. La ingesta de L-arginina durante un mes parece mejorar el control de los niveles de azúcar en la sangre en personas con diabetes. La L-arginina también parece mejorar la sensibilidad de la insulina y la presion sanguínea en personas con diabetes tipo 2.
  • Úlceras del pie diabético. La investigación preliminar muestra que la aplicación diaria de L-arginina para tratar el pie puede mejorar la circulación en personas con diabetes, lo que podría ser beneficioso para prevenir las úlceras del pie diabético. Sin embargo si ya existe una úlcera en el pie, las inyecciones con L-arginina debajo de la piel cerca de la úlcera no parecen acortar el tiempo de cicatrización o disminuir la probabilidad de recurrir a una amputación en el futuro.
  • Daño al sistema nervioso debido a la diabetes. La investigación preliminar sugiere que la ingesta diaria de L-arginina durante tres meses no mejora el daño al sistema nervioso relacionado con la diabetes.
  • Problemas musculares en el esófago. La investigación preliminar sugiere que una infusión de L-arginina y la ingesta de L-arginina durante seis semanas reduce el número y la intensidad de los ataques de dolor en el pecho en personas con problemas musculares en el esófago y el dolor en el pecho no relacionado con el corazón.
  • Rendimiento atlético. Es contradictoria la evidencia sobre la efectividad de la of L-arginina en el rendimiento del ejercicio físico. Cierta evidencia muestra que la ingesta de seis gramos de L-arginina en una bebida mejora el tiempo de ejercicio de ejercicio. Sin embargo, otra evidencia sugiere que la ingesta de L-arginina de manera aislada o junto con antioxidantes (Niteworks, Herbalife International, Inc) no mejora el rendimiento en hombres ciclistas.
  • Cáncer de cabeza y cuello. El suministro de suplementos con L-arginina a través de una sonda nasogástrica no parece mejorar la función inmunitaria, reducir el tamaño del tumor o mejorar la cicatrización en personas con cáncer de cabeza y cuello.
  • Cirugía de derivación aortocoronaria (CABG). Es contradictoria la evidencia sobre la efectividad de la of L-arginina para proteger al corazón durante una CABG. La investigación preliminar sugiere que la administración de L-arginina por vía intravenosa (VI) ayuda a mantener la presión arterial y la irrigación sanguínea en personas sometidas a una CABG. Sin embargo, no reduce las complicaciones después de la cirugía o el tiempo de permanencia en el hospital.
  • Trasplante de corazón. Algunos estudios sugieren que la ingesta diaria de L-arginina durante 6 semanas mejora la distancia de recorrido y mejora la respiración en personas con transplante de corazón.
  • Colesterol alto. La evidencia preliminar muestra que la ingesta diaria de L-arginina durante cuatro semanas no reduce los niveles de grasa en sangre en personas con niveles altos de colesterol.
  • Infertilidad. Es contradictoria la evidencia sobre la efectividad de la of L-arginina en el rendimiento del ejercicio físico. Cierta evidencia muestra que la ingesta diaria de seis gramos de L-arginina aumenta el recuento de óvulos recogidos en una mujer sometida a fertilización in vitro (FIV). Sin embargo, no parece mejorar las tasas de embarazo. Otra investigación sugiere que la ingesta de L-arginina no mejora la calidad del semen en hombres con infertilidad inexplicada.
  • Inflamación de la vejiga. La ingesta de L-arginina parece reducir el dolor y ciertos síntomas de inflamación de la vejiga, aunque las mejorías podrían observarse a los tres meses. Sin embargo, la L-arginina no parece reducir la necesidad de orinar durante la noche o mejorar la frecuencia de la micción.
  • Alteraciones en el crecimiento fetal durante el embarazo. La investigación preliminar sugiere que la ingesta de L-arginina durante el embarazo puede aumentar el peso de los bebés con alteraciones en el crecimiento mientras están en el útero materno. Sin embargo, la L-arginina no parece mejorar el peso al nacer o reducir el riesgo de mortalidad si el bebé tiene un peso extremadamente bajo mientras está en el útero materno.
  • Condición genética que afecta muchos sistemas del cuerpo humano (síndrome MELAS). Existe cierto interés en usar la L-arginina para mejorar los síntomas asociados con el síndrome MELAS. La investigación preliminar sugiere que la administración de L-arginina por vía intravenosa (VI) dentro de la hora posterior a la aparición de los síntomas parecidos a un accidente cerebrovascular mejora las cefaleas, náuseas, vómitos, ceguera y la aparición de destellos de luz.
  • Cefalea por migraña. La ingesta de L-arginina junto con el analgésico ibuprofeno parece ser efectiva para el tratamiento de la cefalea por migraña. Esta combinación a veces comienza a hacer efecto a los 30 minutos. Sin embargo, es difícil saber la magnitud del alivio del dolor que otorga la L-arginina dado que el ibuprofeno puede aliviar por si solo el dolor por migraña.
  • Enfermedad ovárica (síndrome ovárico poliquístico). La investigación preliminar sugiere que la ingesta diaria de N-acetil cisteína y L-arginina durante seis meses puede mejorar la función menstrual y reducir la resistencia a la insulina en personas con síndrome ovárico poliquístico.
  • Úlceras por presión. La evidencia preliminar sugiere que la ingesta diaria de un suplemento que contiene proteínas, energía, arginina, vitamina C y cinc durante nueve semanas puede reducir el tamaño de las úlceras por presion y la supuración.
  • Interrupción del flujo sanguíneo (reestenosis). Cierta evidencia sugiere que la administración de la L-arginina durante el implante de un stent seguido por la ingesta de suplementos de L-arginina durante dos semanas después del implante de stent no reduce el riesgo de sufrir de reestenosis. Sin embargo, otra evidencia sugiere que la administración de L-arginina en el área donde se implantó el stent podría reducir el engrosamiento de las paredes arteriales.
  • Transplante de riñón. Es contradictoria la evidencia sobre la efectividad de la L-arginina en personas con trasplante de riñón. La investigación preliminar sugiere que la administración de L-arginina por vía intravenosa (VI) no mejora la función renal. Sin embargo, otra evidencia sugiere que la L-arginina no mejora la función renal. Estos resultados contradictorios podrían deberse a otros factores relacionados con el trasplante.
  • Infecciones respiratorias. La investigación preliminar sugiere que la ingesta de L-arginina durante 60 días previene la recurrencia de las infecciones respiratorias en niños.
  • Anemia drepanocítica. La investigación preliminar sugiere que la ingesta de L-arginine durante cinco días podría ser beneficiosa en personas con anemia drepanocítica e hipertensión arterial pulmonar.
  • Estrés. Cierta investigación preliminar sugiere que la ingesta de una combinación de L-lisina y L-arginina durante un máximo de 10 días reduce el estrés y la ansiedad en personas sanas y en aquellas propensas a sufrir de estrés.
  • Prevención del resfrío común.
  • Problemas sexuales femeninos.
Se necesita más evidencia para poder aprobar la L-arginina para estos usos.

¿Cómo funciona?

La L-arginina es convertida en el cuerpo en una sustancia química llamada óxido nítrico. El óxido nítrico hace que los vasos sanguíneos se dilaten y así mejora el flujo sanguíneo. La L-arginina además estimula la liberación de la hormona del crecimiento, de la insulina y de otras sustancias en el cuerpo.

¿Hay preocupación por la seguridad de su uso?

L-arginine is POSIBLEMENTE SEGURA en la mayoría de los pacientes cuando se la ingiere de manera apropiada, o se la administra como inyección o se la aplica en la piel por un corto tiempo. Puede producir algunos efectos secundarios tales como dolor abdominal, hinchazón, diarrea, gota, anormalidades de la sangre, alergias, inflamación de las vías respiratorias, empeoramiento del asma y baja presión arterial.

Advertencias y precauciones especiales:

Embarazo y lactancia: La L-arginina es POSIBLEMENTE SEGURA cuando se la ingiere de manera apropiada y por un corto plazo durante el embarazo. No se tiene suficiente información sobre el uso a largo plazo durante el embarazo y la lactancia. Sea precavida y evite su uso.

Niños: La L-arginina es POSIBLEMENTE SEGURA cuando se usa por vía oral en infantes prematuros. Sin embargo, la L-arginina NO ES POSIBLEMENTE SEGURO cuando se lo usa en altas dosis. Las dosis muy altas pueden causar efectos secundarios graves incluidos muerte en niños.

Alergia o asma: La L-arginina puede producir una respuesta alérgica o empeorar la hinchazón de las vías respiratorias. Si usted decide tomar L-arginina, úsela con cuidado.

Cirrosis: La L-arginina debería usarse con precaución en personas con cirrosis.

Carencia de carencia de guanidinoacetato metiltransferasa: Las personas con una condición hereditaria no pueden convertir la arginina y otros químicos Similares en creatinina. Para prevenir complicaciones asociados con esta condición, estas personas no deberían ingerir arginina.

Herpes: Hay preocupación de que la L-arginina podría empeorar el herpes. Hay algunas pruebas que indican que la presencia de L-arginina es necesaria para que el virus del herpes se multiplique.

Presión arterial alta: La L-arginina podría bajar la presión arterial. Esto podría ser un problema si usted ya tiene la presión baja.

Reciente ataque al corazón: Hay preocupación que la L-arginina podría aumentar el riesgo de muerte después de un ataque al corazón, especialmente en las personas de edad avanzada. Si usted ha tenido un ataque al corazón recientemente, no tome L-arginina.

Enfermedad renal: La arginina puede causar complicaciones fatales en personas con enfermedad renal.

Cirugía: La L-arginina podría afectar la presión arterial. Hay preocupación de que podría interferir con el control de la presión arterial durante y después de una cirugía. Deje de tomar L-arginina por lo menos 2 semanas antes de someterse a una cirugía.

¿Existen interacciones con medicamentos?

Serias
No tome esta combinación
Medicamentos para la presión arterial alta
La L-arginina parece disminuir la presión arterial. El tomar L-arginina junto con medicamentos para la presión arterial alta podría hacer que su presión arterial baje demasiado.

Algunos de los medicamentos para la presión arterial alta incluyen captoprila (Capoten), enalaprila (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipina (Norvasc), hidroclotiazida (HydroDiuril), furosemida (Lasix) y muchos otros.
Moderadas
Tenga cuidado con esta combinación
Comprimidos para eliminar la retención de líquido (diuréticos ahorradores de potasio)
La L-arginina también podría aumentar los niveles de potasio. Ciertos comprimidos para eliminar la retención de líquido podría aumentar los niveles de potasio en el cuerpo. En teoría, la ingesta de L-arginina junto con comprimidos para eliminar la retención de líquido podría causar un marcado aumento del nivel de potasio en el cuerpo. Ciertos comprimidos para eliminar la retención de líquido incluyen amilorida (Midamor), espironolactona (Aldactone) y triamterena (Dyrenium).

Ciertos comprimidos para eliminar la retención de líquido y aumentar el nivel de potasio incluyen espironolactona (Aldactone), triamterena (Dyrenium) y la amilorida (Midamor).
Medicamentos para la diabetes (Antidepresivos)
La L-arginina parece disminuir los niveles de azúcar en la sangre en personas con diabetes tipo 2. Los medicamentos para la diabetes también se usan para disminuir los niveles de azúcar en la sangre. La ingesta de L-arginina junto con medicamentos para la diabetes podría causar una marcada disminución de los niveles de azúcar en la sangre. Controle minuciosamente sus niveles de azúcar en sangre. Podría necesitar modificar la dosis de su medicamento para la diabetes.

Algunos medicamentos usados para la diabetes incluyen glimepirida (Amaryl), gliburida (Diabeta, Glynase, PresTab, Micronase), insulina, pioglitazona (Actos), rosiglitazona (Avandia) clorpropamida (Diabinese), glipizida (Glucotrol), tolbutamida (Orinase) y otros.
Medicamentos para la presión arterial alta (bloqueadores de los receptores de angiotensina (BRA))
La L-arginina parece disminuir la presión arterial. La ingesta de L-arginina junto con medicamentos para la presión arterial alta podría causar una marcada disminución de la presión arterial.

Algunos de los BRA incluyen losartan (Cozaar), valsartan (Diovan), irbesartan (Avapro), el candesartan (Atacand), telmisartan (Micardis) y eprosartan (Teveten).
Medicamentos para la presión arterial alta (inhibidores de la ECA)
La L-arginina parece disminuir la presión arterial. La ingesta de L-arginina junto con medicamentos para la presión arterial alta, llamados inhibidores de la ECA, podría causar una marcada disminución de la presión arterial. Además, los inhibidores de la ECA pueden aumentar los niveles de potasio. La L-arginina también podría aumentar los niveles de potasio. La ingesta de L-arginina con los inhibidores de la ECA podría causar un marcado aumento de los niveles de potasio.

Ciertos inhibidores de la ECA incluyen benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace) y trandolapril (Mavik).
Medicamentos para la presión arterial alta (Isoproterenol)
La L-arginina parece disminuir la presión arterial. El isoproterenol es un medicamento usado para disminuir la presión arterial. La ingesta de L-arginina junto con isoproterenol podría causar una marcada disminución de la presión arterial.
Medicamentos que aumentan el flujo de sangre al corazón (Nitratos)
La L-arginina aumenta el flujo de sangre El tomar L-arginina junto con medicamentos que también aumentan el flujo de sangre al corazón podría aumentar las probabilidades de mareos.

Algunos de los medicamentos que aumentan el flujo de sangre al corazón incluyen nitroglicerina (Nitro-Bid, Nitro-Dur, Nitrostat) e isosorbida (Imdur, Isordil, Sorbitrate).
Medicamentos que disminuyen la coagulación de la sangre (Anticoagulantes / Antiplaquetarios)
La L-arginina parece disminuir la coagulación sanguínea. La ingesta de L-arginina junto con medicamentos que también disminuyen la coagulación podría reducir la probabilidad de sufrir hematomas y hemorragia.

Algunos medicamentos que disminuyen la coagulación de la sangre incluyen aspirina, clopidogrel (Plavix), dalteparina (Fragmin), enoxaparina (Lovenox), heparina, ticlopidina (Ticlid), warfarina (Coumadin) entre otros.
Sildenafil (Viagra)
El sildenafil (Viagra) puede bajar la presión arterial. La L-arginina también puede bajar la presión arterial. El tomar sildenafil (Viagra) y L-arginina junto podría hacer que su presión arterial baje demasiado. Si la presión arterial es muy baja puede producir mareos y otros efectos secundarios.

¿Existen interacciones con hierbas y suplementos?

Hierbas y suplementos que podrían disminuir la coagulación de la sangre
La ingesta de L-arginina junto con otras hierbas que pueden disminuir la coagulación de la sangre podría aumentar el riesgo de hemorragia en algunas personas. Estas hierbas incluyen angélica, clavo de olor, danshen, ajo, ginkgo (Ginkgo biloba), Panax ginseng, trébol rojo, cúrcuma entre otros.
Hierbas y suplementos que podrían disminuir la presión arterial
La L-arginina parece disminuir la presión arterial. Si se lo ingiere junto con otras hierbas y suplementos que tienen el mismo efecto podría causar una marcada disminución de la presión arterial en ciertas personas. Algunos de estos productos incluyen andrographis, péptidos de caseína, uña de gato, coenzima Q10, aceite de pescado, L-arginina, licio, ortiga brava, teanina y otros.
Hierbas y suplementos que podrían disminuir los niveles de azúcar en sangre
La L-arginina parece disminuir los niveles de azúcar en la sangre. Consumirla junto con otras hierbas y suplementos que tienen el mismo efecto podría causar una marcada disminución de los niveles de azúcar en la sangre en ciertas personas. Algunos de estos productos incluyen garra del diablo, alholva, goma guar, Panax ginseng, ginseng siberiano y entre otros.
Xylitol
La L-arginina puede hacer que un órgano en el cuerpo llamado páncreas libere una hormona llamada glucagón. El glucagón viene al rescate cuando los niveles de azúcar en la sangre son muy bajos. El glucagón hace que el hígado convierta el azúcar que está almacenada en azúcar lista para usar y la libera al torrente sanguíneo. El usar xylitol junto con L-arginina puede impedir que la L-arginina estimule al páncreas para liberar glucagón.

¿Existen interacciones con alimentos?

No se conoce ninguna interacción con alimentos.

¿Qué dosis se utiliza?

Las siguientes dosis han sido estudiadas en investigaciones científicas:

POR VIA ORAL:
  • Para la insuficiencia cardíaca congestiva: las dosis van desde 6 a 20 gramos al día, en tres dosis divididas.
  • Para el dolor de pecho asociado con la enfermedad arterial coronaria (angina de pecho): se usan 3 a 6 gramos tres veces al día por un período de hasta un año.
  • Para prevenir la pérdida del efecto de la nitroglicerina que se usa para aliviar el dolor en las personas con dolor de pecho debido a la enfermedad arterial coronaria (angina de pecho): se usan 700 mg cuatro veces al día.
  • Para la disfunción eréctil orgánica (ED): se usan 5 gramos al día. El tomar dosis menores podría no ser efectivo.
  • Para prevenir la inflamación del tracto digestivo en los infantes prematuros: se agregan 261 mg/kg diarios a la alimentación oral por los primeros 28 días de vida.

Otros nombres

2-Amino-5-guanidinopentanoic Acid, (2S)-2-Amino-5-{[amino (imino) methyl]amino}pentanoic Acid, Acide 2-Amino-5-guanidinopentanoïque, Arg, Arginine, Arginine Ethyl Ester, Arginine Ethyl Ester Dihydrochloride, Arginine Ethyl Ester HCl, Arginine HCl, Arginine Hydrochloride, Di-Arginine Malate, Di-Arginine Orotate, Di-L-Arginine-L-Malate, Dl-Arginine, L-Arginine Ethyl Ester Dichloride, L-Arginine HCl, L-Arginine Hexanoate, L-Arginine Hydrochloride, L-Arginine Ketoisocaproic Acid, L-Arginine L-Pyroglutamate, L-Arginine Pyroglutamate, L-Arginine Taurinate, Malate de Di-Arginine, Orotate de Di-Arginine, R-Gene 10.

Metodología

Para saber más sobre cómo este artículo fue escrito, refiérase a la metodología de la Base exhaustiva de datos de medicamentos naturales.

Referencias

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  379. George, J., Shmuel, S. B., Roth, A., Herz, I., Izraelov, S., Deutsch, V., Keren, G., and Miller, H. L-arginine attenuates lymphocyte activation and anti-oxidized LDL antibody levels in patients undergoing angioplasty. Atherosclerosis 2004;174:323-327. View abstract.
  380. Dudek, D., Legutko, J., Heba, G., Bartus, S., Partyka, L., Huk, I., Dembinska-Kiec, A., Kaluza, G. L., and Dubiel, J. S. L-arginine supplementation does not inhibit neointimal formation after coronary stenting in human beings: an intravascular ultrasound study. Am Heart J 2004;147:E12. View abstract.
  381. Ahlers, B. A., Parnell, M. M., Chin-Dusting, J. P., and Kaye, D. M. An age-related decline in endothelial function is not associated with alterations in L-arginine transport in humans. J Hypertens. 2004;22:321-327. View abstract.
  382. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol 4-1-2004;93:933-935. View abstract.
  383. Regensteiner, J. G., Popylisen, S., Bauer, T. A., Lindenfeld, J., Gill, E., Smith, S., Oliver-Pickett, C. K., Reusch, J. E., and Weil, J. V. Oral L-arginine and vitamins E and C improve endothelial function in women with type 2 diabetes. Vasc.Med. 2003;8:169-175. View abstract.
  384. Mittermayer, F., Namiranian, K., Pleiner, J., Schaller, G., and Wolzt, M. Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans. Clin.Sci.(Lond) 2004;106:577-581. View abstract.
  385. Zimmermann, C., Wimmer, M., and Haberl, R. L. L-arginine-mediated vasoreactivity in patients with a risk of stroke. Cerebrovasc.Dis 2004;17(2-3):128-133. View abstract.
  386. Jablecka, A., Checinski, P., Krauss, H., Micker, M., and Ast, J. The influence of two different doses of L-arginine oral supplementation on nitric oxide (NO) concentration and total antioxidant status (TAS) in atherosclerotic patients. Med.Sci.Monit. 2004;10:CR29-CR32. View abstract.
  387. Bode-Boger, S. M., Muke, J., Surdacki, A., Brabant, G., Boger, R. H., and Frolich, J. C. Oral L-arginine improves endothelial function in healthy individuals older than 70 years. Vasc.Med. 2003;8:77-81. View abstract.
  388. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82:413-417. View abstract.
  389. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724. View abstract.
  390. Pernow, J., Bohm, F., Beltran, E., and Gonon, A. L-arginine protects from ischemia-reperfusion-induced endothelial dysfunction in humans in vivo. J Appl.Physiol 2003;95:2218-2222. View abstract.
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  392. Robinson, T. M., Sewell, D. A., and Greenhaff, P. L. L-arginine ingestion after rest and exercise: effects on glucose disposal. Med.Sci.Sports Exerc. 2003;35:1309-1315. View abstract.
  393. Houwing, R. H., Rozendaal, M., Wouters-Wesseling, W., Beulens, J. W., Buskens, E., and Haalboom, J. R. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin.Nutr. 2003;22:401-405. View abstract.
  394. McGovern, M. M., Wasserstein, M. P., Aron, A., and Perrine, S. P. Biochemical effect of intravenous arginine butyrate in X-linked adrenoleukodystrophy. J Pediatr 2003;142:709-713. View abstract.
  395. Dallinger, S., Sieder, A., Strametz, J., Bayerle-Eder, M., Wolzt, M., and Schmetterer, L. Vasodilator effects of L-arginine are stereospecific and augmented by insulin in humans. Am J Physiol Endocrinol.Metab 2003;284:E1106-E1111. View abstract.
  396. Schon, T., Elias, D., Moges, F., Melese, E., Tessema, T., Stendahl, O., Britton, S., and Sundqvist, T. Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis. Eur.Respir.J 2003;21:483-488. View abstract.
  397. Abdelhamed, A. I., Reis, S. E., Sane, D. C., Brosnihan, K. B., Preli, R. B., and Herrington, D. M. No effect of an L-arginine-enriched medical food (HeartBars) on endothelial function and platelet aggregation in subjects with hypercholesterolemia. Am Heart J 2003;145:E15. View abstract.
  398. Zimmermann, C. and Haberl, R. L. L-arginine improves diminished cerebral CO2 reactivity in patients. Stroke 2003;34:643-647. View abstract.
  399. Piatti, P., Fragasso, G., Monti, L. D., Setola, E., Lucotti, P., Fermo, I., Paroni, R., Galluccio, E., Pozza, G., Chierchia, S., and Margonato, A. Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels. Circulation 1-28-2003;107:429-436. View abstract.
  400. Sydow, K., Schwedhelm, E., Arakawa, N., Bode-Boger, S. M., Tsikas, D., Hornig, B., Frolich, J. C., and Boger, R. H. ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia: effects of L-arginine and B vitamins. Cardiovasc.Res 2003;57:244-252. View abstract.
  401. Miller, H. I., Dascalu, A., Rassin, T. A., Wollman, Y., Chernichowsky, T., and Iaina, A. Effects of an acute dose of L-arginine during coronary angiography in patients with chronic renal failure: a randomized, parallel, double-blind clinical trial. Am J Nephrol. 2003;23:91-95. View abstract.
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  404. Carey, P. E., Halliday, J., Snaar, J. E., Morris, P. G., and Taylor, R. Direct assessment of muscle glycogen storage after mixed meals in normal and type 2 diabetic subjects. Am J Physiol Endocrinol.Metab 2003;284:E688-E694. View abstract.
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  406. Lekakis, J. P., Papathanassiou, S., Papaioannou, T. G., Papamichael, C. M., Zakopoulos, N., Kotsis, V., Dagre, A. G., Stamatelopoulos, K., Protogerou, A., and Stamatelopoulos, S. F. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Int.J Cardiol 2002;86(2-3):317-323. View abstract.
  407. Griffin, N., Zimmerman, D. D., Briel, J. W., Gruss, H. J., Jonas, M., Acheson, A. G., Neal, K., Scholefield, J. H., and Schouten, W. R. Topical L-arginine gel lowers resting anal pressure: possible treatment for anal fissure. Dis Colon Rectum 2002;45:1332-1336. View abstract.
  408. Zvan, B., Zaletel, M., Pogacnik, T., and Kiauta, T. Testing of cerebral endothelium function with L-arginine after stroke. Int.Angiol. 2002;21:256-259. View abstract.
  409. Song, J. X., Qing, S. H., Huang, X. C., and Qi, D. L. Effect of parenteral nutrition with L-arginine supplementation on postoperative immune function in patients with colorectal cancer. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22:545-547. View abstract.
  410. Bennett-Richards, K. J., Kattenhorn, M., Donald, A. E., Oakley, G. R., Varghese, Z., Bruckdorfer, K. R., Deanfield, J. E., and Rees, L. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int. 2002;62:1372-1378. View abstract.
  411. Schaefer, A., Piquard, F., Geny, B., Doutreleau, S., Lampert, E., Mettauer, B., and Lonsdorfer, J. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int.J Sports Med. 2002;23:403-407. View abstract.
  412. Cassone, Faldetta M., Laurenti, O., Desideri, G., Bravi, M. C., De, Luca O., Marinucci, M. C., De, Mattia G., and Ferri, C. L-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients. Diabetologia 2002;45:1120-1127. View abstract.
  413. Fukumoto, Y., Urabe, Y., Kubo, T., Kaku, T., Egashira, K., Shimokawa, H., and Takeshita, A. Augmented vasodilator response to L-arginine after coronary angioplasty may attenuate restenosis. Heart Vessels 2002;16:171-174. View abstract.
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  418. Schramm, L., La, M., Heidbreder, E., Hecker, M., Beckman, J. S., Lopau, K., Zimmermann, J., Rendl, J., Reiners, C., Winderl, S., Wanner, C., and Schmidt, H. H. L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation. Kidney Int. 2002;61:1423-1432. View abstract.
  419. Carrier, M., Pellerin, M., Perrault, L. P., Bouchard, D., Page, P., Searle, N., and Lavoie, J. Cardioplegic arrest with L-arginine improves myocardial protection: results of a prospective randomized clinical trial. Ann.Thorac.Surg. 2002;73:837-841. View abstract.
  420. Kawano, H., Motoyama, T., Hirai, N., Kugiyama, K., Yasue, H., and Ogawa, H. Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress. Atherosclerosis 2002;161:375-380. View abstract.
  421. Maejima, K., Himeno, M., Ishibashi, T., Nakano, S., Nishio, M., and Uchida, K. Paradoxical decrease in plasma NOx by L-arginine load in diabetic and non-diabetic subjects. Clin.Exp.Hypertens. 2002;24:155-167. View abstract.
  422. Suzuki, T., Hayase, M., Hibi, K., Hosokawa, H., Yokoya, K., Fitzgerald, P. J., Yock, P. G., Cooke, J. P., Suzuki, T., and Yeung, A. C. Effect of local delivery of L-arginine on in-stent restenosis in humans. Am J Cardiol 2-15-2002;89:363-367. View abstract.
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  424. Chowdhary, S., Nuttall, S. L., Coote, J. H., and Townend, J. N. L-arginine augments cardiac vagal control in healthy human subjects. Hypertension 2002;39:51-56. View abstract.
  425. Marchesi, S., Lupattelli, G., Siepi, D., Roscini, A. R., Vaudo, G., Sinzinger, H., and Mannarino, E. Oral L-arginine administration attenuates postprandial endothelial dysfunction in young healthy males. J Clin.Pharm.Ther 2001;26:343-349. View abstract.
  426. Bello, E., Caramelo, C., Martell, N., Alcazar, J. M., Gonzalez, J., Lopez, M. D., Ruilope, L. M., Gonzalez, F. R., Rovira, A. M., Gazapo, R., Soldevilla, M. J., and Casado, S. Impairment of renal vasodilation with l-arginine is related to more severe disease in untreated hypertensive patients. Hypertension 2001;38:907-912. View abstract.
  427. Mantovani, F., Patelli, E., Colombo, F., Pozzoni, F., Confalonieri, S., and Pisani, E. [Erectile dysfunction after non-nerve sparing radical pelvic surgery. Therapeutical experience with sildenafil and L-arginine evaluated by Buckling test]. Minerva Med. 2001;92:285-287. View abstract.
  428. Walker, H. A., McGing, E., Fisher, I., Boger, R. H., Bode-Boger, S. M., Jackson, G., Ritter, J. M., and Chowienczyk, P. J. Endothelium-dependent vasodilation is independent of the plasma L-arginine/ADMA ratio in men with stable angina: lack of effect of oral L-arginine on endothelial function, oxidative stress and exercise performance. J Am Coll.Cardiol 2001;38:499-505. View abstract.
  429. Zhang, X. Z., Ardissino, G., Ghio, L., Tirelli, A. S., Dacco, V., Colombo, D., Pace, E., Testa, S., and Claris-Appiani, A. L-arginine supplementation in young renal allograft recipients with chronic transplant dysfunction. Clin.Nephrol. 2001;55:453-459. View abstract.
  430. Piatti, P. M., Monti, L. D., Valsecchi, G., Magni, F., Setola, E., Marchesi, F., Galli-Kienle, M., Pozza, G., and Alberti, K. G. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 2001;24:875-880. View abstract.
  431. Okamoto, M., Etani, H., Yagita, Y., Kinoshita, N., and Nukada, T. Diminished reserve for cerebral vasomotor response to L-arginine in the elderly: evaluation by transcranial Doppler sonography. Gerontology 2001;47:131-135. View abstract.
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  434. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir.Crit Care Med. 2001;163:887-891. View abstract.
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  436. van Bokhorst-De Van Der Schueren, MA, Quak, J. J., von Blomberg-van der Flier BM, Kuik, D. J., Langendoen, S. I., Snow, G. B., Green, C. J., and van Leeuwen, P. A. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am.J Clin.Nutr 2001;73:323-332. View abstract.
  437. Morris, C. R., Kuypers, F. A., Larkin, S., Sweeters, N., Simon, J., Vichinsky, E. P., and Styles, L. A. Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease. Br J Haematol. 2000;111:498-500. View abstract.
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  440. Gianotti, L., Braga, M., Gentilini, O., Balzano, G., Zerbi, A., and Di, Carlo, V. Artificial nutrition after pancreaticoduodenectomy. Pancreas 2000;21:344-351. View abstract.
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  443. Wideman, L., Weltman, J. Y., Patrie, J. T., Bowers, C. Y., Shah, N., Story, S., Veldhuis, J. D., and Weltman, A. Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise. Am J Physiol Regul.Integr.Comp Physiol 2000;279:R1467-R1477. View abstract.
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  448. Maxwell, A. J., Anderson, B. E., and Cooke, J. P. Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc.Med. 2000;5:11-19. View abstract.
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