United States National Library of Medicine National Institutes of Health

2008AB Gene Ontology Source Information

Counts
Relationship Relationship Attribute Count (MRREL.RRF)
SIB * 807466
SY * 89688
PAR inverse_isa 35490
RO * 8516
RN * 7895
RN part_of 4011
SY mth_has_expanded_form 1526
RO regulates 1097
RQ consider 1061
RO negatively_regulates 961
RO positively_regulates 941
RQ replaced_by 425
PAR inverse_isa 3
Background
  • * Indicates blank relationship attribute (rela); not all relationships are assigned an attribute.
  • Orange colored rel/rela pairs indicate that the current row is an inverse relationship of the row above it. All relationships in MRREL.RRF are bi-directional.
  • Metathesaurus relationships are traditionally read from right to left.
  • Every row in MRREL.RRF has a RUI (relationship unique identifier).
  • Samples below are taken from MRREL.RRF, although not every field is shown. Associated terms (str) from MRCONSO.RRF are also shown for clarity.
  • Relationship abbreviations appear in MRREL, i.e., SY.
Relationship Definitions
  • AQ: allowed qualifier
  • CHD: has child (narrower hierarchical term)
  • DEL: deleted concept
  • PAR: has parent (broader hierarchical term)
  • QB: can be qualifier by
  • RB: has a broader relationship
  • RL: has similar or like relationship
  • RN: has narrower relationship
  • RO: has relationship other than synonymous, narrower or broader
  • RQ: related and possibly synonymous
  • SIB: has sibling
  • SY: source-asserted synonymy
Sample Data
SIB  (return to top)
cui1 aui1 stype1 str rel cui2 aui2 stype2 str
C1151481 A11608170 SDUI 3-phenylpropionate dioxygenase activity SIB C1151491 A11596745 SDUI biphenyl 2,3-dioxygenase activity
C1151491 A11596745 SDUI biphenyl 2,3-dioxygenase activity SIB C1151481 A11608170 SDUI 3-phenylpropionate dioxygenase activity
C1167152 A11600380 SDUI nucleotide-excision repair complex SIB C0598988 A11588706 SDUI nuclear pore
C0598988 A11588706 SDUI nuclear pore SIB C1167152 A11600380 SDUI nucleotide-excision repair complex
C1324161 A11605820 SDUI mannitol 2-dehydrogenase (NADP+) activity SIB C1324100 A11618087 SDUI coniferyl-alcohol dehydrogenase activity
C1324100 A11618087 SDUI coniferyl-alcohol dehydrogenase activity SIB C1324161 A11605820 SDUI mannitol 2-dehydrogenase (NADP+) activity
C1167178 A11618869 SDUI tRNA-intron endonuclease complex SIB C1167281 A11591076 SDUI type III protein secretion system complex
C1167281 A11591076 SDUI type III protein secretion system complex SIB C1167178 A11618869 SDUI tRNA-intron endonuclease complex
C1151269 A11595701 SDUI UDP-N-acetylmuramate dehydrogenase activity SIB C1324126 A11586857 SDUI glucose 1-dehydrogenase activity
C1324126 A11586857 SDUI glucose 1-dehydrogenase activity SIB C1151269 A11595701 SDUI UDP-N-acetylmuramate dehydrogenase activity
SY  (return to top)
cui1 aui1 stype1 str rel cui2 aui2 stype2 str
C1149024 A11601194 AUI sodium:potassium-exchanging ATPase activity SY C1149024 A11613546 AUI sodium/potassium-exchanging ATPase activity
C1149024 A11613546 AUI sodium/potassium-exchanging ATPase activity SY C1149024 A11601194 AUI sodium:potassium-exchanging ATPase activity
C1325932 A11587226 AUI positive regulation of T cell receptor signaling pathway SY C1325932 A11612161 AUI positive regulation of TCR signaling pathway
C1325932 A11612161 AUI positive regulation of TCR signaling pathway SY C1325932 A11587226 AUI positive regulation of T cell receptor signaling pathway
C1149951 A11613401 AUI [pyruvate dehydrogenase (lipoamide)] phosphatase activity SY C1149951 A11613402 AUI [pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity
C1149951 A11613402 AUI [pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity SY C1149951 A11613401 AUI [pyruvate dehydrogenase (lipoamide)] phosphatase activity
C1154426 A11586332 AUI positive regulation of action potential SY C2249509 A14238304 AUI up regulation of action potential
C2249509 A14238304 AUI up regulation of action potential SY C1154426 A11586332 AUI positive regulation of action potential
C1150098 A11608875 AUI cytosol alanyl aminopeptidase activity SY C2266350 A14236520 AUI soluble alanyl aminopeptidase activity
C2266350 A14236520 AUI soluble alanyl aminopeptidase activity SY C1150098 A11608875 AUI cytosol alanyl aminopeptidase activity
PAR  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1158284 A11621716 SDUI homoacetate catabolic process PAR inverse_isa C1158283 A11615567 SDUI acetate fermentation
C1158283 A11615567 SDUI acetate fermentation CHD isa C1158284 A11621716 SDUI homoacetate catabolic process
C1151312 A11583065 SDUI ubiquinol-cytochrome-c reductase activity PAR inverse_isa C1153611 A14262686 SDUI hydrogen ion transmembrane transporter activity
C1153611 A14262686 SDUI hydrogen ion transmembrane transporter activity CHD isa C1151312 A11583065 SDUI ubiquinol-cytochrome-c reductase activity
C1523534 A11609885 SDUI histone deacetylation at centromere PAR inverse_isa C1156201 A11615045 SDUI histone deacetylation
C1156201 A11615045 SDUI histone deacetylation CHD isa C1523534 A11609885 SDUI histone deacetylation at centromere
C1523277 A11593668 SDUI microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine PAR inverse_isa C1159284 A11621361 SDUI protein amino acid esterification
C1159284 A11621361 SDUI protein amino acid esterification CHD isa C1523277 A11593668 SDUI microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine
C1159285 A11615138 SDUI protein amino acid flavinylation PAR inverse_isa C0033666 A14259152 SDUI post-translational protein modification
C0033666 A14259152 SDUI post-translational protein modification CHD isa C1159285 A11615138 SDUI protein amino acid flavinylation
RO  (return to top)
cui1 aui1 stype1 str rel cui2 aui2 stype2 str
C1155661 A11582682 AUI mismatch repair RO C1817268 A14241037 AUI mismatch repair, MutL-like pathway
C1817268 A14241037 AUI mismatch repair, MutL-like pathway RO C1155661 A11582682 AUI mismatch repair
C1150582 A11594784 AUI MAP kinase kinase kinase activity RO C1150582 A14251265 AUI MLTK
C1150582 A14251265 AUI MLTK RO C1150582 A11594784 AUI MAP kinase kinase kinase activity
C1151132 A11595625 AUI cholesterol monooxygenase (side-chain-cleaving) activity RO C2263543 A14235978 AUI enzymes, cholesterol side-chain-cleaving
C2263543 A14235978 AUI enzymes, cholesterol side-chain-cleaving RO C1151132 A11595625 AUI cholesterol monooxygenase (side-chain-cleaving) activity
C1167227 A11601856 AUI integrin complex RO C1325804 A14272794 AUI laminin receptor protein
C1325804 A14272794 AUI laminin receptor protein RO C1167227 A11601856 AUI integrin complex
C1749583 A14261014 AUI regulation of systemic arterial blood pressure by norepinephrine-epinephrine RO C1622391 A14261015 AUI norepinephrine-epinephrine blood pressure control
C1622391 A14261015 AUI norepinephrine-epinephrine blood pressure control RO C1749583 A14261014 AUI regulation of systemic arterial blood pressure by norepinephrine-epinephrine
RN  (return to top)
cui1 aui1 stype1 str rel cui2 aui2 stype2 str
C1817320 A11594415 AUI positive regulation of neuroblast proliferation RN C2248009 A14245142 AUI stimulation of neuroblast proliferation
C2248009 A14245142 AUI stimulation of neuroblast proliferation RB C1817320 A11594415 AUI positive regulation of neuroblast proliferation
C1152371 A11607074 AUI DNA-directed DNA polymerase activity RN C1152372 A14261260 AUI DNA polymerase alpha
C1152372 A14261260 AUI DNA polymerase alpha RB C1152371 A11607074 AUI DNA-directed DNA polymerase activity
C1155020 A11623465 AUI negative regulation of cytotoxic T cell differentiation RN C2249222 A14243481 AUI inhibition of cytotoxic T cell differentiation
C2249222 A14243481 AUI inhibition of cytotoxic T cell differentiation RB C1155020 A11623465 AUI negative regulation of cytotoxic T cell differentiation
C2247639 A14237722 AUI aminoglycoside nucleotidyltransferase activity RN C2247643 A14237723 AUI streptomycin adenylylase activity
C2247643 A14237723 AUI streptomycin adenylylase activity RB C2247639 A14237722 AUI aminoglycoside nucleotidyltransferase activity
C1819399 A14258285 AUI negative regulation of type I interferon production RN C2245690 A14237139 AUI inhibition of type I interferon production
C2245690 A14237139 AUI inhibition of type I interferon production RB C1819399 A14258285 AUI negative regulation of type I interferon production
RN  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1160389 A11597314 SDUI lung development RN part_of C1326653 A11617933 SDUI alveolus development
C1326653 A11617933 SDUI alveolus development RB has_part C1160389 A11597314 SDUI lung development
C1522876 A11593244 SDUI mesoderm morphogenesis RN part_of C1522882 A11593245 SDUI mesoderm structural organization
C1522882 A11593245 SDUI mesoderm structural organization RB has_part C1522876 A11593244 SDUI mesoderm morphogenesis
C1624015 A14274957 SDUI nuclear replisome RN part_of C1167123 A11608158 SDUI epsilon DNA polymerase complex
C1167123 A11608158 SDUI epsilon DNA polymerase complex RB has_part C1624015 A14274957 SDUI nuclear replisome
C1818235 A11590907 SDUI cerebellar Purkinje cell layer development RN part_of C1818246 A11615694 SDUI cerebellar Purkinje cell layer maturation
C1818246 A11615694 SDUI cerebellar Purkinje cell layer maturation RB has_part C1818235 A11590907 SDUI cerebellar Purkinje cell layer development
C1156310 A11620081 SDUI induction by virus of cell-cell fusion in host RN part_of C2262910 A14276800 SDUI syncytium formation by plasma membrane fusion of virally targeted cells
C2262910 A14276800 SDUI syncytium formation by plasma membrane fusion of virally targeted cells RB has_part C1156310 A11620081 SDUI induction by virus of cell-cell fusion in host
SY  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1621443 A11628509 AUI death-inducing signaling complex location SY mth_has_expanded_form C1621443 A11591338 AUI death-inducing signaling complex
C1621443 A11591338 AUI death-inducing signaling complex SY mth_expanded_form_of C1621443 A11628509 AUI death-inducing signaling complex location
C1523878 A11629361 AUI Fanconi anaemia nuclear complex location SY mth_has_expanded_form C1523878 A11604622 AUI Fanconi anaemia nuclear complex
C1523878 A11604622 AUI Fanconi anaemia nuclear complex SY mth_expanded_form_of C1523878 A11629361 AUI Fanconi anaemia nuclear complex location
C1167305 A11591013 AUI light-harvesting complex location (sensu Gram-negative Bacteria) SY mth_has_expanded_form C1167305 A11603509 AUI light-harvesting complex (sensu Gram-negative Bacteria)
C1167305 A11603509 AUI light-harvesting complex (sensu Gram-negative Bacteria) SY mth_expanded_form_of C1167305 A11591013 AUI light-harvesting complex location (sensu Gram-negative Bacteria)
C1167050 A11612767 AUI exosome (RNase complex location) SY mth_has_expanded_form C1167050 A11625074 AUI exosome (RNase complex)
C1167050 A11625074 AUI exosome (RNase complex) SY mth_expanded_form_of C1167050 A11612767 AUI exosome (RNase complex location)
C2265260 A14250340 AUI Hrd1p ubiquitin ligase ERAD-M complex location SY mth_has_expanded_form C2265260 A14255635 AUI Hrd1p ubiquitin ligase ERAD-M complex
C2265260 A14255635 AUI Hrd1p ubiquitin ligase ERAD-M complex SY mth_expanded_form_of C2265260 A14250340 AUI Hrd1p ubiquitin ligase ERAD-M complex location
RO  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1327446 A11625262 SDUI type IIa hypersensitivity RO regulates C1327447 A11581825 SDUI regulation of type IIa hypersensitivity
C1327447 A11581825 SDUI regulation of type IIa hypersensitivity RO regulated_by C1327446 A11625262 SDUI type IIa hypersensitivity
C1156167 A11607531 SDUI cell wall chitin biosynthetic process RO regulates C2246210 A14242470 SDUI regulation of cell wall chitin biosynthetic process
C2246210 A14242470 SDUI regulation of cell wall chitin biosynthetic process RO regulated_by C1156167 A11607531 SDUI cell wall chitin biosynthetic process
C1159733 A11621005 SDUI purine nucleoside transport RO regulates C1819149 A11604046 SDUI regulation of purine nucleoside transport
C1819149 A11604046 SDUI regulation of purine nucleoside transport RO regulated_by C1159733 A11621005 SDUI purine nucleoside transport
C1819403 A11610215 SDUI Ral protein signal transduction RO regulates C1819404 A11591619 SDUI regulation of Ral protein signal transduction
C1819404 A11591619 SDUI regulation of Ral protein signal transduction RO regulated_by C1819403 A11610215 SDUI Ral protein signal transduction
C1155227 A14269485 SDUI tumor necrosis factor biosynthetic process RO regulates C1155222 A14237888 SDUI regulation of tumor necrosis factor biosynthetic process
C1155222 A14237888 SDUI regulation of tumor necrosis factor biosynthetic process RO regulated_by C1155227 A14269485 SDUI tumor necrosis factor biosynthetic process
RQ  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1150612 A11625731 SDUI transmembrane receptor protein tyrosine kinase activity RQ consider C1150631 A11594845 SDUI neurotrophin TRKC receptor activity
C1150631 A11594845 SDUI neurotrophin TRKC receptor activity RQ consider_from C1150612 A11625731 SDUI transmembrane receptor protein tyrosine kinase activity
C0598312 A11613787 SDUI DNA replication RQ consider C1155629 A11606602 SDUI DNA replication and chromosome cycle
C1155629 A11606602 SDUI DNA replication and chromosome cycle RQ consider_from C0598312 A11613787 SDUI DNA replication
C1325774 A14262497 SDUI 1-2nm peptidoglycan-based cell wall RQ consider C1325774 A11609647 SDUI cell wall inner membrane
C1325774 A11609647 SDUI cell wall inner membrane RQ consider_from C1325774 A14262497 SDUI 1-2nm peptidoglycan-based cell wall
C1325891 A11611620 SDUI negative regulation of follicle-stimulating hormone secretion RQ consider C1149455 A11608992 SDUI inhibin
C1149455 A11608992 SDUI inhibin RQ consider_from C1325891 A11611620 SDUI negative regulation of follicle-stimulating hormone secretion
C1523111 A11624519 SDUI chaperone binding RQ consider C1149554 A11588315 SDUI co-chaperone activity
C1149554 A11588315 SDUI co-chaperone activity RQ consider_from C1523111 A11624519 SDUI chaperone binding
RO  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1817968 A11594527 SDUI B cell deletion RO negatively_regulates C1819880 A11613190 SDUI negative regulation of B cell deletion
C1819880 A11613190 SDUI negative regulation of B cell deletion RO negatively_regulated_by C1817968 A11594527 SDUI B cell deletion
C1155230 A11597087 SDUI antimicrobial humoral response RO negatively_regulates C1155247 A11594071 SDUI negative regulation of antimicrobial humoral response
C1155247 A11594071 SDUI negative regulation of antimicrobial humoral response RO negatively_regulated_by C1155230 A11597087 SDUI antimicrobial humoral response
C1326060 A11597447 SDUI polarized epithelial cell differentiation RO negatively_regulates C1326062 A11603707 SDUI negative regulation of polarized epithelial cell differentiation
C1326062 A11603707 SDUI negative regulation of polarized epithelial cell differentiation RO negatively_regulated_by C1326060 A11597447 SDUI polarized epithelial cell differentiation
C1155169 A11598029 SDUI interleukin-23 biosynthetic process RO negatively_regulates C1155171 A11586195 SDUI negative regulation of interleukin-23 biosynthetic process
C1155171 A11586195 SDUI negative regulation of interleukin-23 biosynthetic process RO negatively_regulated_by C1155169 A11598029 SDUI interleukin-23 biosynthetic process
C1820202 A11599561 SDUI leucophore differentiation RO negatively_regulates C1820206 A11587012 SDUI negative regulation of leucophore differentiation
C1820206 A11587012 SDUI negative regulation of leucophore differentiation RO negatively_regulated_by C1820202 A11599561 SDUI leucophore differentiation
RO  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1158886 A11601485 SDUI protein amino acid phosphorylation RO positively_regulates C1522758 A11600632 SDUI positive regulation of protein amino acid phosphorylation
C1522758 A11600632 SDUI positive regulation of protein amino acid phosphorylation RO positively_regulated_by C1158886 A11601485 SDUI protein amino acid phosphorylation
C1156031 A11626338 SDUI microtubule depolymerization RO positively_regulates C1621982 A11616039 SDUI positive regulation of microtubule depolymerization
C1621982 A11616039 SDUI positive regulation of microtubule depolymerization RO positively_regulated_by C1156031 A11626338 SDUI microtubule depolymerization
C0683143 A11602652 SDUI RNA metabolic process RO positively_regulates C1523268 A11599918 SDUI positive regulation of RNA metabolic process
C1523268 A11599918 SDUI positive regulation of RNA metabolic process RO positively_regulated_by C0683143 A11602652 SDUI RNA metabolic process
C1819278 A11628774 SDUI intracellular sterol transport RO positively_regulates C1819294 A11604078 SDUI positive regulation of intracellular sterol transport
C1819294 A11604078 SDUI positive regulation of intracellular sterol transport RO positively_regulated_by C1819278 A11628774 SDUI intracellular sterol transport
C1819425 A11628801 SDUI connective tissue growth factor production RO positively_regulates C1819547 A11591658 SDUI positive regulation of connective tissue growth factor production
C1819547 A11591658 SDUI positive regulation of connective tissue growth factor production RO positively_regulated_by C1819425 A11628801 SDUI connective tissue growth factor production
RQ  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1149036 A11613241 SDUI GTPase activity RQ replaced_by C1149040 A11582109 SDUI small monomeric GTPase activity
C1149040 A11582109 SDUI small monomeric GTPase activity RQ replaces C1149036 A11613241 SDUI GTPase activity
C1154824 A11584243 SDUI toluene metabolic process RQ replaced_by C1326946 A11623671 SDUI toluene synthesis
C1326946 A11623671 SDUI toluene synthesis RQ replaces C1154824 A11584243 SDUI toluene metabolic process
C1148676 A11590592 SDUI centromeric DNA binding RQ replaced_by C1326861 A11601667 SDUI centromere binding
C1326861 A11601667 SDUI centromere binding RQ replaces C1148676 A11590592 SDUI centromeric DNA binding
C1152834 A11629219 SDUI Wnt receptor activity RQ replaced_by C1152834 A14262017 SDUI Wnt receptor activity
C1152834 A14262017 SDUI Wnt receptor activity RQ replaces C1152834 A11629219 SDUI Wnt receptor activity
C1323412 A11586721 SDUI sodium-transporting ATPase activity, rotational mechanism RQ replaced_by C1622485 A14262822 SDUI ATP synthase
C1622485 A14262822 SDUI ATP synthase RQ replaces C1323412 A11586721 SDUI sodium-transporting ATPase activity, rotational mechanism
PAR  (return to top)
cui1 aui1 stype1 str rel rela cui2 aui2 stype2 str
C1148560 A11607042 SDUI molecular_function PAR inverse_isa C1138831 A2379761 AUI Gene Ontology
C1138831 A2379761 AUI Gene Ontology CHD isa C1148560 A11607042 SDUI molecular_function
C1166607 A11625888 SDUI cellular_component PAR inverse_isa C1138831 A2379761 AUI Gene Ontology
C1138831 A2379761 AUI Gene Ontology CHD isa C1166607 A11625888 SDUI cellular_component
C0031845 A11601819 SDUI biological_process PAR inverse_isa C1138831 A2379761 AUI Gene Ontology
C1138831 A2379761 AUI Gene Ontology CHD isa C0031845 A11601819 SDUI biological_process

Last reviewed: 02 February 2009
Last updated: 02 February 2009
First published: 02 February 2009
Metadata| Permanence level: Permanence Not Guaranteed