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Grants and Funding: Extramural Programs (EP)

Special Instructions for NLM Applied Informatics Grant Applications


The specific SF424 (R&R) Application forms package to be used for submitting an application to this program is linked from the funding opportunity announcement (FOA), RFA-LM-12-001. Please do not use any other forms package. To download the application forms package:
  1. Click on
  2. Look for the grey elongated button labeled “Apply for Grant Electronically”
    Apply for Grant Electronically
  3. Click on the button (or click on the button above), and this will take you to the web page to download the correct applications package.
The instructions on this web page are to be followed in conjunction with the instructions as set out in the “SF424 (R&R) Application Guide – Adobe Forms Version B” at and in the FOA. In cases where the instructions on this page differ from instructions in the Application Guide, the instructions on this page supersede all other instructions.

Only sections from the Application Guide that require clarification are addressed below.

4.6 Selecting the Appropriate Budget Component (page I-71 of Application Guide) A R&R Budget Component is required for the G08 grant program. Please complete the R&R (Research & Related) Budget Component to submit your detailed categorical budget, following the instructions in section 4.7 on page I-72. Please disregard the Modular Budget Guidelines.

Please leave the Indirect Costs sections blank as this program does not cover indirect costs (facilities and administrative costs), as stated in the FOA.

5.5 PHS 398 Research Plan Component (page I-106 of Application Guide)
Please follow the instructions as set out in the Application Guide, with the following clarifications.

Page limits as set out in the FOA are:
  • Specific Aims is limited to 1 page.
  • Research Strategy, including tables, graphs, figures, diagrams and charts, is limited to 12 pages.
The section headers as set out below and in the Application Guide must be followed. The research plan should describe the aims of the project, what will be done, the people who will carry out the work, the people who will be affected, and how the project will be managed. The following sections outline the kind of information that should be in the research plan.

Refer to the Review Criteria in Section V of the FOA to see what the reviewers will be looking for when they review the application.

1. Introduction to Application
Use only for a resubmission (revised application).

2. Specific Aims (see page I-109 of Application Guide)
Clearly state the project's aims. Why does the applicant want to do this and what benefit is it expected to bring to the organizations and communities involved? Relate them to the objectives of the grant program as stated in the FOA.

3. Research Strategy (see page I-109 of Application Guide)
Organize the Research Strategy in the specified order and use the instructions provided below. Start each section with the appropriate section heading - Significance, Innovation, and Approach.

  1. Significance
    Discuss the information need and its context, supported by published evidence as appropriate. Provide a rationale for the resource or service. Describe the applicant organization(s) and performance sites. Who are the primary clients to be served by the proposed project? Describe how the proposed project meets their needs. Summarize the potential impact in terms of types and numbers of users who will benefit.
  2. Innovation
    corporate into your application as relevant. As the goal of the G08 grant program is to develop information resources, it is not expected that proposed projects will include novel theoretical concepts, approaches or methodologies, as may be expected for research projects.

    Describe how your project may be useful as a model for other organizations that wish to undertake similar work.
  3. Approach
    Report accomplishments to date in preparing for the project, especially the preliminary supporting evidence gathered from identifying user needs or bringing a planning committee together or testing prototypes.

    For each specific aim, explain how it will be achieved, providing evidence for a user-centered approach to development and deployment where appropriate. Provide a timeline that shows the milestones and duration and sequence of the steps for reaching them.

    If the project includes the development of a web-based resource, discuss how content features such as selection, source credibility, currency, accuracy, and completeness will be addressed. Discuss how use, growth, and user characteristics will be tracked.

    Training and Evaluation
    Describe how the users will be trained to use the system or resource, as appropriate. How will your project be evaluated? If funds are requested for project staff to receive technical training, describe the nature of the training and provide a rationale for it. An evaluation section should provide an evaluation approach for each specific aim and, if appropriate, outcome measures or other more general evaluation plans.

    Personnel & Project Management
    Describe the roles of the key personnel - who is responsible for doing the work and for making certain that work is completed correctly and on time? If consultants are to be used, describe their roles and qualifications. Describe the techniques and kinds of information that will be used to monitor progress and judge the success of the project. Where objectives are amenable to quantification, the evaluation can be a straightforward analysis of pre-grant and post-grant data. What kinds of information will be gathered to assess the impact that the project has on the organization's ability to meet its goals?

    Describe how you will promote use of the resource or service. Describe how you will disseminate findings - the outcomes of your work, the lessons learned, etc. to the broader community. If unique resources are being developed, describe what is to be made available to the broader community for use by others.

    Future Support
    How will financial and technical support be provided after the grant ends? Will arrangements be made to provide users with additional training and/or resources and services?
Other Sections (not part of the 12-page Research Strategy)

Human Subjects Section: f the project involves gathering health-related information from identifiable individuals, or access to personal health information, assurance of adequate protection for human subjects must be provided. These sections should follow SF424 (R&R) Application Guide instructions (see Application Guide page I-111, 6. Protection of Human Subjects).

Letters of Support: If a consultant is to be used, attach a letter describing the consultant's role on the project. If collaborating organizations are named, it is wise to include letters that confirm their intention to participate. Refer to the Application Guide, page I-115.

Appendix: Applicants may attach selected materials relevant to the project, including cost estimates, memoranda of understanding, and the like. Appendices should not contain such information as budget, timelines and milestones; that information belongs in the application itself. All appendix materials must conform to the Appendix instructions on pages I-116 to I-117 of the Application Guide.