Robert Bunsen
Arne Tiselius
Robert Bunsen
Robert Bunsen
National Library of Medicine
Image 1 of 2

Key accomplishments: toxicology


Richard Mead
First Publication on Poisons

Richard Mead's A Mechanical Account of Poisons in Several Essays is the first book in English devoted entirely to the discussion of poisons.


First Chemical Tests in a Trial

The Mary Blandy case in England is the first reported use of chemical tests to detect arsenic in a legal trial.


Mathieu Orfila
First Toxicology Publication

In France, Mathieu Orfila's Traité des Poisons is the first book devoted entirely to the subject of toxicology. Orfila popularizes the word "toxicology."


James Marsh
Marsh Test Devised

English chemist James Marsh devises a test for identifying trace amounts of arsenic.


Jean-Servais Stas
Alkaloid Poison Test Developed

Belgian chemist Jean-Servais Stas develops a method for detecting vegetable alkaloid poisons (caffeine, quinine, morphine, strychnine, atropine, opium) in dead bodies.


Robert Wilhelm Eberhard Bunsen and Gustav Robert Kirchhoff
Spectrum Analysis Developed

With the aid of the spectroscope, which they invented in 1859, German chemist Robert Bunsen and physicist Gustav Kirchhoff discover that vaporizing a substance creates a unique "signature" spectrum, which can be used to identify it. Using the spectroscope, in 1860, Bunsen and Kirchhoff discover two new alkali metals—cesium and rubidium.


Mikhail Tswett
Paper Chromatography Developed

Italian-born Russian botanist Mikhail Tswett invents paper chromatography, initially to study the make-up of plant proteins such as chlorophyll.


Theodor Svedberg
Ultracentrifuge Developed

Swedish chemist Theodor Svedberg builds the first ultracentrifuge—a machine that separates particles by mass—making it possible to determine precisely the molecular weights of highly complex proteins. Svedberg wins the Nobel Prize for Chemistry in 1926 for his invention of the ultracentrifuge and studies in the chemistry of colloids.


Arnold Beckman, Howard Cary and Warren Baxter at National Technical Laboratories (now Beckman Coulter)
Ultraviolet Spectrophotometer Introduced

The Beckman model DU spectrophotometer is the first instrument to probe the ultraviolet region with high precision and accuracy. According to Bruce Merrifield, Nobel Laureate in chemistry, the DU is "probably the most important instrument ever developed in the advancement of bioscience."


Arne Tiselius
Electrophoresis and Adsorption Developed

During the 1920s and 1930s, Swedish chemist Arne Tiselius helps develop and improve electrophoresis and analysis by adsorption. In 1948, he receives the Nobel Prize in Chemistry for his work.


New Technologies Incorporated

Ultraviolet and infrared spectrometry, X-ray diffraction, and paper chromatography are applied to forensic science.


Richard L. M. Synge and Archer J. P. Martin
Partition Chromatography Developed

British biochemists Archer J. P. Martin and Richard L. M. Synge demonstrate partition chromatography to the Biochemical Society at a 1941 meeting in London. They share the Nobel Prize in Chemistry in 1952 for their development of partition chromatography.


Gas Chromatography Developed

The first commercial gas chromatograph is manufactured.


New Technologies Incorporated

Fourier-transformed infrared spectroscopy (FTIR), a technique that measures various infrared wavelengths, and atomic absorption spectroscopy, which uses the absorption of light to measure the concentration of gas-phase atoms, are invented.