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250 Years of American Medicine
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Mind and Brain

Between the founding of the U.S. in 1776 and today, medical research into patients’ minds and brains has shifted from the field of philosophy to the natural and social sciences. During this time, researchers have become increasingly interested in the ways in which various physical and chemical structures in the brain contribute to human cognition. This in turn has revolutionized how we see learning, memory, and indeed mental health. Learn more about this historical transition in the digital gallery below.

1776-1826
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1776-1826

In the Early Republic, varying levels of medical training and limited professional standards yielded loosely organized practice of medicine. People sought out common therapeutic practices—including bloodletting, purging, surgery, and home remedies—from family members, communities, and physicians. Shaped by wars and limited public sanitation, smallpox, yellow fever, and other infectious diseases were major health concerns. The spread of smallpox inoculation, expanding medical education, and scientific inquiry advanced the medical profession. Explore a selection of NLM items produced between 1776 and 1826. Topics include wartime medicine, smallpox inoculation, Native American health and healing, yellow fever epidemics, botanicals and herbal remedies, and more.

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1827-1876
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1827-1876

American medicine became more organized during the 19th century as medical schools, hospitals, and professional societies expanded, though standards and training varied widely. Physicians practiced surgery, obstetrics, and emerging scientific medicine, while many people also turned to homeopathy and other alternative therapies. Infectious diseases such as cholera, smallpox, and rabies remained major threats, prompting growing interest in quarantine, sanitation, and public health. Significant advances included the use of ether anesthesia, improvements from Civil War medicine, and the development of professional nursing. Presented is an assortment of National Library of Medicine collection items printed between 1827 and 1876, covering topics such as homeopathy, nursing, infectious disease, administering ether, sanitation, women in medicine, Civil War medicine, and more.

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1877-1926
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1877-1926

Between 1877 and 1926, American medicine became increasingly scientific and professionalized as medical education and licensing became required by the states. Physicians relied on laboratory science, surgery, nursing care, and new diagnostic tools, while some Americans used widely advertised patent medicines alongside conventional treatments. Infectious diseases such as tuberculosis, influenza, rabies, and yellow fever remained major concerns, driving advances in public health and disease prevention, including the development of several vaccines. Germ theory, antiseptic surgery, X-rays, bacteriology, and the discovery of insulin transformed medical practice and outcomes. View this selection of items from the NLM collection produced from 1877 to 1926, which include works about pharmacology, surgery, infectious disease, public health, nursing, World War I medicine, and more.

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1927-1976
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1927-1976

By the mid-20th century, American medicine had become highly professionalized as physicians, nurses, hospitals, and public health agencies took on leading roles in healthcare. Medical practice increasingly relied on laboratory science, pharmaceuticals, vaccinations, and advanced technologies. These changes led to many Americans receiving care through hospitals, clinics, and expanding insurance systems. Infectious diseases declined as sulfa drugs, antibiotics, and vaccines transformed treatment and prevention. Chronic diseases, smoking-related illnesses, and environmental health concerns gained attention. Major medical breakthroughs included blood banking, open-heart surgery, organ transplantation, and DNA research. Explore a selection of NLM collection items produced between 1927 and 1976 about the discovery of DNA, substance use, World War II medicine, environmental health, computers in medicine, biotechnology, and more.

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1977-2026
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1977-2026

Since 1977, American medicine has become more technologically advanced and evidence based. Physicians, nurses, and allied professionals deliver specialized and team-based care. Patients access health services through hospitals, outpatient clinics, telemedicine, and digital health platforms, reflecting major changes in communications and access. Many health concerns from years past persist, like cancer and mental health disorders, while new ones have emerged, including the opioid epidemic, infectious diseases such as Ebola and COVID-19, and chronic conditions tied to lifestyle and aging populations. Advances in genomics, imaging, immunotherapy, and artificial intelligence continue to transform diagnosis and treatment, alongside major public health campaigns and public policy responses. Browse these NLM collection items created between 1977 and 2026, on subjects including HIV/AIDS, COVID-19, the opioid epidemic, mental health, telemedicine, public health communications, and more.

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Anatomy and Surgery
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Anatomy and Surgery

In the United States, the histories of anatomy and surgery have long been closely intertwined. Whereas early physicians often relied on limited anatomical knowledge and rudimentary surgical procedures to treat patients, later improvements in fields such as education, anesthesia, antibiotics, and blood transfusion made operations safer and more effective. Learn more about some of these important historical developments in this digital gallery.

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Cultures of Medicine
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Cultures of Medicine

Medicine has always involved cultural forces that impact the discipline as a whole. These forces impact the way in which individual physicians undertake their work and researchers discover various treatments for diseases. From stories about doctors and patients to the organizations that support their efforts, medical professionals are part of a broader system that helps to keep the entire nation healthy. Scroll through this digital gallery to learn more about the cultural history of medicine in the U.S.

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Diseases and Conditions
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Diseases and Conditions

Over the past 250 years, the list of diseases and conditions that affect people in the U.S. has changed dramatically. In the early Republic, cholera, yellow fever, and smallpox were among the leading causes of death. Today, advances in sanitation and public health mean that these illnesses have been eradicated or replaced, leaving chronic conditions such as cancer, diabetes, and heart disease as the most pressing health concerns. Learn about the changing history of diseases and related conditions in this digital gallery.

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Drugs and Treatments
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Drugs and Treatments

Drugs and therapeutic treatments have played an important role in U.S. medicine since the founding of the country in 1776. Whereas early physicians generally relied on traditional methods such as bloodletting and herbal remedies, later advances in vaccines, pharmaceuticals, antibiotics, and chemotherapy have helped to radically to improve patients’ health. Learn more about the development of some of these innovative drugs and treatments in this digital gallery.

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Laboratory Science
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Laboratory Science

Researchers working in laboratories across the United States have made some of the most important medical breakthroughs of the last 250 years. These include the first use of general anesthesia and the discovery of the cause of yellow fever, as well as more recent innovations like recombinant DNA technology, GLP-1 inhibitors, and CAR-T Cell therapy. Learn about a handful of these important laboratory discoveries in this digital gallery.

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Medical Technology
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Medical Technology

Since 1776, the history of medical technology in the United States has often reflected the broader scientific, industrial, and social progress of the nation. From the earliest surgical tools used during the Revolutionary War to more recent developments such as artificial heart valves and magnetic resonance imaging (MRI), U.S. technical innovation has always proceeded hand in hand with improvements in patient health. Learn more about some of these incredible inventions in this digital gallery.

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Military Medicine
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Military Medicine

Throughout its history, the United States has participated in numerous armed conflicts that have contributed to the growth of military medicine. From the War of Independence to the U.S. Civil War and more recent struggles in Europe, Vietnam, and Afghanistan, the country has relied on a dedicated group of doctors, nurses, and field medics to keep their troops healthy and combat ready. Learn more about their stories and the history of U.S. military medicine in this digital gallery.

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Mind and Brain
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Mind and Brain

Between the founding of the U.S. in 1776 and today, medical research into patients’ minds and brains has shifted from the field of philosophy to the natural and social sciences. During this time, researchers have become increasingly interested in the ways in which various physical and chemical structures in the brain contribute to human cognition. This in turn has revolutionized how we see learning, memory, and indeed mental health. Learn more about this historical transition in the digital gallery below.

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Preventive Medicine
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Preventive Medicine

Though we often think of preventive medicine as a recent historical development, the idea of taking proactive steps to ensure personal health is at least as old as the United States itself. For centuries, U.S. doctors and physicians have recommended a wide variety of herbal remedies, workout regimes, and dietary plans—each designed to help their patients live a healthier lifestyle. Learn about some of these innovative and unusual therapies in this digital gallery.

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Public Health
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Public Health

Public health has shaped the medical, political, and social life of the United States since the nation was first born two and a half centuries ago. Beginning with the efforts of local officials to contain an outbreak of Yellow Fever in Philadelphia in 1793, the U.S. government has consistently played an important role in improving living conditions and promoting healthy behaviors in communities all across the country. Learn more about the history of U.S. public health in this digital gallery.

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Audiovisuals
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Audiovisuals

Moving images serve as a vital tool for health education, document significant events and breakthroughs in medicine, and provide a way of sharing scientific scholarship. Explore this selection of audiovisual materials in the NLM collection, produced over the past century, originally in film, videocassette, and webcast.

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Born-Digital
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Born-Digital

Since the mid-20th century, digital media has transformed American health and medicine, changing how medical knowledge is created, shared, and preserved; empowering patients with greater access to information; enabling community action in the pursuit of wellbeing; and accelerating biomedical research and discovery. Learn about born-digital materials in the NLM collection, including websites and software, in this digital gallery.

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Manuscripts
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Manuscripts

Medical manuscripts document the development of American medicine. Physicians, researchers, students, hospitals, and public health officials manually record and collect observations, treatments, research findings, and institutional activities. These records support medical education and facilitate the exchange of knowledge. Today, medical manuscripts remain invaluable sources for understanding the scientific, social, and cultural history of health and medicine in the United States. Explore this selection of working notes and correspondence from clinicians, researchers, and patients.

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Still Images
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Still Images

From anatomical drawings and clinical photographs to public health posters and advertisements, still images help doctors diagnose illness, communicate scientific knowledge, educate the public, and shape perceptions of medicine. They have also served as records of medical practice, scientific discovery, and patient experience, preserving visual evidence of how health and medicine have evolved over time. Explore a selection of these still images from the collection in this digital gallery.

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Texts
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Texts

Over the past 250 years, medical texts have been the primary means of organizing and sharing medical knowledge gained in America. Textbooks, journals, and reference works have standardized medical education and clinical practice while supporting the professionalization of the field. They have enabled scientific communication, recorded shifting understandings of disease, and translated research into practice. Medical texts also provide a lasting scholarly record that continues to inform education, care, and historical research. Explore this assortment of medical texts from the NLM collection.

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22 Images

The title page of Animal Magnetism.

Animal Magnetism, Benjamin Franklin, Paris, France, 1785

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The title page of Animal Magnetism.
  • LocatorPlus Catalog
  • NLM Medicine in the Americas
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The title page of An Essay on the Truth of Physiognomy.

An Essay on the Truth of Physiognomy, Richard Brown, Philadelphia, PA: Thomas T. Stiles, 1807

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The title page of An Essay on the Truth of Physiognomy.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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An illustration of a man strapped to a chair with a large wooden block covering the top part of his head and eyes.

"The Tranquilizing Chair of Benjamin Rush" from The Philadelphia Medical Museum, Benjamin Rush, Philadelphia, PA: John Coxe Redman, 1811

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An illustration of a man strapped to a chair with a large wooden block covering the top part of his head and eyes.
  • NLM Digital Collections
  • NLM Early American Psychiatry: Diseases of the Mind Website
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An image depicting two thermometers entitled Temperance and Intemperance, each of which are labeled with a series of more or less healthy alcoholic beverages.

"A Moral and Physical Thermometer"from An Inquiry into the Effects of Ardent Spirits upon the Human Body and Mind, Benjamin Rush, Boston, MA: Manning & Loring, 1812

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An image depicting two thermometers entitled Temperance and Intemperance, each of which are labeled with a series of more or less healthy alcoholic beverages.
  • NLM Digital Collections
  • Exhibition - Pick Your Poison: Intoxicating Pleasures and Medical Prescriptions
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The title page of Proposals for Establishing a Retreat for the Insane.

Proposals for Establishing a Retreat for the Insane, George Parkman, Boston, MA: John Eliot, 1814

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The title page of Proposals for Establishing a Retreat for the Insane.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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A table describing the different nerves in the human head, as well as their function, origin, course, connections, and appearance in other mammals.

Neurological Table: Exhibiting a View of the Nerves of the Head (Table), John Davidson Godman, Philadelphia, PA, 1823

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A table describing the different nerves in the human head, as well as their function, origin, course, connections, and appearance in other mammals.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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An illustration of a mans head, which has been divided up into sections that are labeled using Roman numberals.

Elements of Phrenology, Charles Caldwell, Lexington, KY: A.G. Meriwether, 1827

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An illustration of a mans head, which has been divided up into sections that are labeled using Roman numberals.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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An illustration of a parlor scene in which a man is staring intently at a woman seated in a chair while another man holds a sheet of paper in front of her face.

A New Theory of Animal Magnetism, Charles Ferson Durant, New York, NY: Wiley & Putnam, 1837

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An illustration of a parlor scene in which a man is staring intently at a woman seated in a chair while another man holds a sheet of paper in front of her face.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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The title page of Facts in Mesmerism, and Thoughts on its Causes and Uses.

Facts in Mesmerism, and Thoughts on its Causes and Uses, Charles Caldwell, Louisville, KY: Prentice and Weissinger, 1842

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The title page of Facts in Mesmerism, and Thoughts on its Causes and Uses.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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A book page with three illustrations: one of a large, iron spike next to a skull for size comparison, one of a skull impaled by an iron spike, and a third of the base view of a skull with a hole created by an iron spike.

Recovery from the Passage of an Iron Bar through the Head, John Harlow, Boston, MA: David Clapp & Son, 1869

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A book page with three illustrations: one of a large, iron spike next to a skull for size comparison, one of a skull impaled by an iron spike, and a third of the base view of a skull with a hole created by an iron spike.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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A color illustration of the cross-section of the descending colon with small ulcers.

The Medical and Surgical History of the War of the rebellion (1861–65), U.S. Surgeon General's Office, Washington, DC: Government Publishing Office (GPO), 1870

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A color illustration of the cross-section of the descending colon with small ulcers.
  • NLM Digital Collections
  • Exhibition - Life and Limb: The Toll of the American Civil War
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A German-language letter stitched into a brown cloth.

Letters Stitched in Cloth: Stockton Insane Asylum, Anna B. Kuster Welty, Stockton, CA , 1877

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A German-language letter stitched into a brown cloth.
  • NLM Digital Collections
  • Exhibition - Care and Custody: Past Responses to Mental Health
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The title page of a book with the logo of The Riverside Press, an image of a sitting figure hugging a tree while playing flute under a banner with the words Tout bien ou rien, in the center.

The Subconscious, Joseph Jastrow, New York, NY: Riverside Press, 1906

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The title page of a book with the logo of The Riverside Press, an image of a sitting figure hugging a tree while playing flute under a banner with the words Tout bien ou rien, in the center.
  • NLM Digital Collections
  • NLM Medicine in the Americas Website
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A title page of a book with an illustration of a torch in the center.

Defects Found in Drafted Men, Albert C. Love and Charles B. Davenport, Washington, DC: Government Printing Office (GPO), 1919

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A title page of a book with an illustration of a torch in the center.
  • NLM Digital Collections
  • NLM Digital Collections - World War I Collection
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A movie still of a white man laughing.

Pathological Laughing and Crying: St. Elizabeth's Hospital 1930, St. Elizabeths Hospital, Washington, DC, 1930

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A movie still of a white man laughing.
  • NLM Digital Collections
  • Exhibition - Care and Custody: Past Responses to Mental Health
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Film showing a uniformed Navy seaman suffering from different stages of combat fatigue.

Combat Fatigue Irritability, U.S. Navy, Washington, DC: Navy Department, Bureau of Aeronautics, 1945

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Film showing a uniformed Navy seaman suffering from different stages of combat fatigue.
  • NLM Digital Collections
  • Medicine on Screen: Films and Essays from NLM
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A poster showing a colorful boardgame.

The Name of the Game is Drug Abuse Prevention: Any Number Can Play (Poster), National Institute on Drug Abuse (NIDA), Bethesda, MD: National Institute on Drug Abuse (NIDA), 1970

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A poster showing a colorful boardgame.
  • NLM Digital Collections
  • Exhibition - Pick Your Poison: Intoxicating Pleasures and Medical Prescriptions
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A black and white poster showing a hand holding an egg which represents your brain, a hot frying pan with melted butter bubbling, representing drugs, an egg frying in a pan, representing your brain on drugs,and a cracked egg surrounded by text.

This Is Your Brain, This Is Drugs, This Is Your Brain on Drugs (Poster), Partnership for a Drug-Free America, 1980

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A black and white poster showing a hand holding an egg which represents your brain, a hot frying pan with melted butter bubbling, representing drugs, an egg frying in a pan, representing your brain on drugs,and a cracked egg surrounded by text.
  • NLM Digital Collections
  • Exhibition - Pick Your Poison: Intoxicating Pleasures and Medical Prescriptions
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Several labeled medical illustrations showing parts of neurons and how they communicate with chemical and electrical signals.

Mental Health: A Report of the Surgeon General , National Institute of Mental Health (NIMH), Washington, DC: U.S. Public Health Service, Office of the Surgeon General, 1999

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Several labeled medical illustrations showing parts of neurons and how they communicate with chemical and electrical signals.
  • NLM Digital Collections
  • Profiles in Science - Reports of the Surgeon General
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Graph showing that Medicaid expenditures for home and community-based services steadily rising as spending for Institutional services falls. The graph shows steady change from 1981 to 2015 with a crossover point at 2013.

Creating Better Systems of Care for Adults with Disabilities: Lessons for Policy and Practice, Martha Hostetter and Sarah Klein, New York, NY: Commonwealth Fund, 2018

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Graph showing that Medicaid expenditures for home and community-based services steadily rising as spending for Institutional services falls. The graph shows steady change from 1981 to 2015 with a crossover point at 2013.
  • NLM Digital Collections
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Diagram of interactions with children, family, and community expanding out from an individual with a substance abuse disorder.

The Ripple Effect: The Impact of the Opioid Epidemic on Children and Families, Suzanne C. Brundage and Carol Levine, New York, NY: United Hospital Fund, 2019

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Diagram of interactions with children, family, and community expanding out from an individual with a substance abuse disorder.
  • NLM Digital Collections
  • NLM Opioid Epidemic Web Archive
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Digital poster for the talk with a photograph of the speaker, a young white woman with long dark hair.

Anorexia in the Archives: Documenting the Late Twentieth Century Rise in Eating Disorders, Alice Weinreb, Bethesda, MD: National Library of Medicine, 2024

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Digital poster for the talk with a photograph of the speaker, a young white woman with long dark hair.
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