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Drugs and Treatments

Drugs and therapeutic treatments have played an important role in U.S. medicine since the founding of the country in 1776. Whereas early physicians generally relied on traditional methods such as bloodletting and herbal remedies, later advances in vaccines, pharmaceuticals, antibiotics, and chemotherapy have helped to radically to improve patients’ health. Learn more about the development of some of these innovative drugs and treatments in this digital gallery.

1776-1826
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1776-1826

In the Early Republic, varying levels of medical training and limited professional standards yielded loosely organized practice of medicine. People sought out common therapeutic practices—including bloodletting, purging, surgery, and home remedies—from family members, communities, and physicians. Shaped by wars and limited public sanitation, smallpox, yellow fever, and other infectious diseases were major health concerns. The spread of smallpox inoculation, expanding medical education, and scientific inquiry advanced the medical profession. Explore a selection of NLM items produced between 1776 and 1826. Topics include wartime medicine, smallpox inoculation, Native American health and healing, yellow fever epidemics, botanicals and herbal remedies, and more.

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1827-1876
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1827-1876

American medicine became more organized during the 19th century as medical schools, hospitals, and professional societies expanded, though standards and training varied widely. Physicians practiced surgery, obstetrics, and emerging scientific medicine, while many people also turned to homeopathy and other alternative therapies. Infectious diseases such as cholera, smallpox, and rabies remained major threats, prompting growing interest in quarantine, sanitation, and public health. Significant advances included the use of ether anesthesia, improvements from Civil War medicine, and the development of professional nursing. Presented is an assortment of National Library of Medicine collection items printed between 1827 and 1876, covering topics such as homeopathy, nursing, infectious disease, administering ether, sanitation, women in medicine, Civil War medicine, and more.

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1877-1926
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1877-1926

Between 1877 and 1926, American medicine became increasingly scientific and professionalized as medical education and licensing became required by the states. Physicians relied on laboratory science, surgery, nursing care, and new diagnostic tools, while some Americans used widely advertised patent medicines alongside conventional treatments. Infectious diseases such as tuberculosis, influenza, rabies, and yellow fever remained major concerns, driving advances in public health and disease prevention, including the development of several vaccines. Germ theory, antiseptic surgery, X-rays, bacteriology, and the discovery of insulin transformed medical practice and outcomes. View this selection of items from the NLM collection produced from 1877 to 1926, which include works about pharmacology, surgery, infectious disease, public health, nursing, World War I medicine, and more.

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1927-1976
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1927-1976

By the mid-20th century, American medicine had become highly professionalized as physicians, nurses, hospitals, and public health agencies took on leading roles in healthcare. Medical practice increasingly relied on laboratory science, pharmaceuticals, vaccinations, and advanced technologies. These changes led to many Americans receiving care through hospitals, clinics, and expanding insurance systems. Infectious diseases declined as sulfa drugs, antibiotics, and vaccines transformed treatment and prevention. Chronic diseases, smoking-related illnesses, and environmental health concerns gained attention. Major medical breakthroughs included blood banking, open-heart surgery, organ transplantation, and DNA research. Explore a selection of NLM collection items produced between 1927 and 1976 about the discovery of DNA, substance use, World War II medicine, environmental health, computers in medicine, biotechnology, and more.

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1977-2026
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1977-2026

Since 1977, American medicine has become more technologically advanced and evidence based. Physicians, nurses, and allied professionals deliver specialized and team-based care. Patients access health services through hospitals, outpatient clinics, telemedicine, and digital health platforms, reflecting major changes in communications and access. Many health concerns from years past persist, like cancer and mental health disorders, while new ones have emerged, including the opioid epidemic, infectious diseases such as Ebola and COVID-19, and chronic conditions tied to lifestyle and aging populations. Advances in genomics, imaging, immunotherapy, and artificial intelligence continue to transform diagnosis and treatment, alongside major public health campaigns and public policy responses. Browse these NLM collection items created between 1977 and 2026, on subjects including HIV/AIDS, COVID-19, the opioid epidemic, mental health, telemedicine, public health communications, and more.

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Anatomy and Surgery
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Anatomy and Surgery

In the United States, the histories of anatomy and surgery have long been closely intertwined. Whereas early physicians often relied on limited anatomical knowledge and rudimentary surgical procedures to treat patients, later improvements in fields such as education, anesthesia, antibiotics, and blood transfusion made operations safer and more effective. Learn more about some of these important historical developments in this digital gallery.

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Cultures of Medicine
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Cultures of Medicine

Medicine has always involved cultural forces that impact the discipline as a whole. These forces impact the way in which individual physicians undertake their work and researchers discover various treatments for diseases. From stories about doctors and patients to the organizations that support their efforts, medical professionals are part of a broader system that helps to keep the entire nation healthy. Scroll through this digital gallery to learn more about the cultural history of medicine in the U.S.

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Diseases and Conditions
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Diseases and Conditions

Over the past 250 years, the list of diseases and conditions that affect people in the U.S. has changed dramatically. In the early Republic, cholera, yellow fever, and smallpox were among the leading causes of death. Today, advances in sanitation and public health mean that these illnesses have been eradicated or replaced, leaving chronic conditions such as cancer, diabetes, and heart disease as the most pressing health concerns. Learn about the changing history of diseases and related conditions in this digital gallery.

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Drugs and Treatments
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Drugs and Treatments

Drugs and therapeutic treatments have played an important role in U.S. medicine since the founding of the country in 1776. Whereas early physicians generally relied on traditional methods such as bloodletting and herbal remedies, later advances in vaccines, pharmaceuticals, antibiotics, and chemotherapy have helped to radically to improve patients’ health. Learn more about the development of some of these innovative drugs and treatments in this digital gallery.

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Laboratory Science
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Laboratory Science

Researchers working in laboratories across the United States have made some of the most important medical breakthroughs of the last 250 years. These include the first use of general anesthesia and the discovery of the cause of yellow fever, as well as more recent innovations like recombinant DNA technology, GLP-1 inhibitors, and CAR-T Cell therapy. Learn about a handful of these important laboratory discoveries in this digital gallery.

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Medical Technology
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Medical Technology

Since 1776, the history of medical technology in the United States has often reflected the broader scientific, industrial, and social progress of the nation. From the earliest surgical tools used during the Revolutionary War to more recent developments such as artificial heart valves and magnetic resonance imaging (MRI), U.S. technical innovation has always proceeded hand in hand with improvements in patient health. Learn more about some of these incredible inventions in this digital gallery.

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Military Medicine
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Military Medicine

Throughout its history, the United States has participated in numerous armed conflicts that have contributed to the growth of military medicine. From the War of Independence to the U.S. Civil War and more recent struggles in Europe, Vietnam, and Afghanistan, the country has relied on a dedicated group of doctors, nurses, and field medics to keep their troops healthy and combat ready. Learn more about their stories and the history of U.S. military medicine in this digital gallery.

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Mind and Brain
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Mind and Brain

Between the founding of the U.S. in 1776 and today, medical research into patients’ minds and brains has shifted from the field of philosophy to the natural and social sciences. During this time, researchers have become increasingly interested in the ways in which various physical and chemical structures in the brain contribute to human cognition. This in turn has revolutionized how we see learning, memory, and indeed mental health. Learn more about this historical transition in the digital gallery below.

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Preventive Medicine
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Preventive Medicine

Though we often think of preventive medicine as a recent historical development, the idea of taking proactive steps to ensure personal health is at least as old as the United States itself. For centuries, U.S. doctors and physicians have recommended a wide variety of herbal remedies, workout regimes, and dietary plans—each designed to help their patients live a healthier lifestyle. Learn about some of these innovative and unusual therapies in this digital gallery.

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Public Health
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Public Health

Public health has shaped the medical, political, and social life of the United States since the nation was first born two and a half centuries ago. Beginning with the efforts of local officials to contain an outbreak of Yellow Fever in Philadelphia in 1793, the U.S. government has consistently played an important role in improving living conditions and promoting healthy behaviors in communities all across the country. Learn more about the history of U.S. public health in this digital gallery.

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Audiovisuals
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Audiovisuals

Moving images serve as a vital tool for health education, document significant events and breakthroughs in medicine, and provide a way of sharing scientific scholarship. Explore this selection of audiovisual materials in the NLM collection, produced over the past century, originally in film, videocassette, and webcast.

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Born-Digital
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Born-Digital

Since the mid-20th century, digital media has transformed American health and medicine, changing how medical knowledge is created, shared, and preserved; empowering patients with greater access to information; enabling community action in the pursuit of wellbeing; and accelerating biomedical research and discovery. Learn about born-digital materials in the NLM collection, including websites and software, in this digital gallery.

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Manuscripts
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Manuscripts

Medical manuscripts document the development of American medicine. Physicians, researchers, students, hospitals, and public health officials manually record and collect observations, treatments, research findings, and institutional activities. These records support medical education and facilitate the exchange of knowledge. Today, medical manuscripts remain invaluable sources for understanding the scientific, social, and cultural history of health and medicine in the United States. Explore this selection of working notes and correspondence from clinicians, researchers, and patients.

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Still Images
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Still Images

From anatomical drawings and clinical photographs to public health posters and advertisements, still images help doctors diagnose illness, communicate scientific knowledge, educate the public, and shape perceptions of medicine. They have also served as records of medical practice, scientific discovery, and patient experience, preserving visual evidence of how health and medicine have evolved over time. Explore a selection of these still images from the collection in this digital gallery.

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Texts
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Texts

Over the past 250 years, medical texts have been the primary means of organizing and sharing medical knowledge gained in America. Textbooks, journals, and reference works have standardized medical education and clinical practice while supporting the professionalization of the field. They have enabled scientific communication, recorded shifting understandings of disease, and translated research into practice. Medical texts also provide a lasting scholarly record that continues to inform education, care, and historical research. Explore this assortment of medical texts from the NLM collection.

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29 Images

The title page of An Epitome of the Theory and Practice of Physic.

An Epitome of the Theory and Practice of Physic, Hartford, CT: Watson and Goodwin, 1778

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The title page of An Epitome of the Theory and Practice of Physic.
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The title page of The New Method of Inoculating for the Small Pox.

The New Method of Inoculating for the Small Pox, Benjamin Rush, Philadelphia, PA: Charles Cist, 1781

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The title page of The New Method of Inoculating for the Small Pox.
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The title page of A Narrative of a Discovery of a Sovereign Specific for the Cure of Cancers.

A Narrative of a Discovery of a Sovereign Specific for the Cure of Cancers, Hugh Martin, Philadelphia, PA: Robert Aitken, 1782

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The title page of A Narrative of a Discovery of a Sovereign Specific for the Cure of Cancers.
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The title page of Observations on the Superior Efficacy of the Red Peruvian Bark in the Cure of Agues and Other Fevers.

Observations on the Superior Efficacy of the Red Peruvian Bark in the Cure of Agues and Other Fevers, William Saunders, Robert Hodge: Boston, MA, 1783

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The title page of Observations on the Superior Efficacy of the Red Peruvian Bark in the Cure of Agues and Other Fevers.
Observations on the Superior Efficacy of the Red Peruvian Bark in the Cure of Agues and Other Fevers, William Saunders, Boston, MA: Robert Hodge, 1783
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The title page of a handwritten manuscript entitled Notes from a Course of Lectures ... with a Surgeon Generals Office Library stamp.

Notes from a course of lectures on the practice of physic delivered by Benjamin Rush, 1786

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The title page of a handwritten manuscript entitled Notes from a Course of Lectures ... with a Surgeon Generals Office Library stamp.
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The title page of An Historical Account of the Climates and Diseases of the United States of America.

An Historical Account of the Climates and Diseases of the United States of America, William Currie, Philadelphia, PA: T. Dobson, 1792

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The title page of An Historical Account of the Climates and Diseases of the United States of America.
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The title page of Medical Advice to Seamen.

Medical Advice to Seamen, Samuel Holden Parsons Lee, New London, CT: Samuel Green, 1795

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The title page of Medical Advice to Seamen.
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The title page of The American Herbal, or Materia Medica.

The American Herbal, or Materia Medica, Samuel Stearns, Walpole, NH: David Carlisle, 1801

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The title page of The American Herbal, or Materia Medica.
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An image depicting a series of pustules cause by the cowpox vaccine and those caused by smallpox of a number of days.

Practical Observations on Vaccination, or Inoculation for the Cow-Pock, John Redman Coxe, Philadelphia, PA: James Humphreys, 1802

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An image depicting a series of pustules cause by the cowpox vaccine and those caused by smallpox of a number of days.
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A page from an old handwritten book that provides recipes for treating diseases such as fever and epilepsy.

Recipe Book, William Elmer, 1810

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A page from an old handwritten book that provides recipes for treating diseases such as fever and epilepsy.
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The title page of A Treatise on the Nature and Cure of Gout and Rheumatism.

A Treatise on the Nature and Cure of Gout and Rheumatism, Charles Scudamore, Philadelphia, PA: Edward Earle, 1819

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The title page of A Treatise on the Nature and Cure of Gout and Rheumatism.
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A list of deaths in Savannah from July to November 1830, including the names of the deceased, their ages, their country of origin, and the cause of death.

An Official Register of Deaths in the City of Savannah, Savannah, GA: Henry P. Russell, 1820

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A list of deaths in Savannah from July to November 1830, including the names of the deceased, their ages, their country of origin, and the cause of death.
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The title page of Historical Sketch of the Thomsonian System of the Practice of Medicine on Botanical Principles.

Historical Sketch of the Thomsonian System of the Practice of Medicine on Botanical Principles, John Thomson, Albany, NY: B.D. Packard and Co., 1830

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The title page of Historical Sketch of the Thomsonian System of the Practice of Medicine on Botanical Principles.
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The title page of The North American Indian Doctor, or, Natures Method of Curing and Preventing disease According to the Indians.

The North American Indian Doctor, or, Nature's Method of Curing and Preventing Disease According to the Indians, Robert Foster, Canton, OH : Smith and Bevin, 1838

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The title page of The North American Indian Doctor, or, Natures Method of Curing and Preventing disease According to the Indians.
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The title page of Remarks on the Proper Mode of Administering Sulphuric Ether by Inhalation

Remarks on the Proper Mode of Administering Sulphuric Ether by Inhalation, William Morton, Boston, MA: Dutton and Wentworth, 1847

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The title page of Remarks on the Proper Mode of Administering Sulphuric Ether by Inhalation
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The title page of A Practical Treatise on Poisons.

A Practical Treatise on Poisons, O.H. Costill, Philadelphia, PA: Grigg, Elliot & Co., 1848

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The title page of A Practical Treatise on Poisons.
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A book cover illustrated in an art nouveau style showing the words Humphreys Homeopathic Manual with three vignettes: one with a statue of a woman lying on a lion above the words The Mild Power Cures, one with a Grecian-looking woman holding onto a tree branch above the words Witch Hazel oil,

Humphreys' Homepathic Manual, Frederick Humphreys, New York, NY: Humphreys' Specific Homeopathic Medicine Co., 1884

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A book cover illustrated in an art nouveau style showing the words Humphreys Homeopathic Manual with three vignettes: one with a statue of a woman lying on a lion above the words The Mild Power Cures, one with a Grecian-looking woman holding onto a tree branch above the words Witch Hazel oil,
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Title page of a book with an Army Medical Library stamp.

New Manual of Alkaloidal Therapeutics, Adophe Burggraeve, Chicago, IL: Geo. T. Halla, 1888

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Title page of a book with an Army Medical Library stamp.
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The front and back covers of a folded patent medicine advertisement card show two chromolithographic illustrations: the front side has a vignette of a bubbling brook inset in an oval, above it the signature of the company founder J. Liebig, in the lower left corner a medicine bottle; on the front si

Liebig Company's Extract of Beef (Chromolithograph), 1890

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The front and back covers of a folded patent medicine advertisement card show two chromolithographic illustrations: the front side has a vignette of a bubbling brook inset in an oval, above it the signature of the company founder J. Liebig, in the lower left corner a medicine bottle; on the front si
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An advertisement for a patent medicine showing an illustration of three white children wearing newspaper hats: a boy with sailor suit-inspired clothing, holding a toy cutlass; a girl holding a wooden stick; and a small girl holding a doll and a toy bugle.

Scott's Emulsion Calendar (Chromolithograph), New York, NY: Scott & Browne, 1893

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An advertisement for a patent medicine showing an illustration of three white children wearing newspaper hats: a boy with sailor suit-inspired clothing, holding a toy cutlass; a girl holding a wooden stick; and a small girl holding a doll and a toy bugle.
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The title page for Introduction to the Rarer Elements.

Introduction to the Rarer Elements, Phillip Browning, New York, NY: John Wiley & Sons, 1904

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The title page for Introduction to the Rarer Elements.
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A journal with red cover and white text and photographs.

Medicine Under Canvas: A War Journal of the 77th Evacuation Hospital, Max Allen, Kansas City, MO: Sosland Press, 1949

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A journal with red cover and white text and photographs.
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A film still of a diagram describing the hormonal fluctuations of the menstrual cycle.

Mechanisms of Action of the Oral Contraceptives, Syntex Laboratories, Palo Alto, CA: Aegis Productions, 1966

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A film still of a diagram describing the hormonal fluctuations of the menstrual cycle.
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A poster showing a colorful boardgame.

The Name of the Game is Drug Abuse Prevention: Any Number Can Play (Poster), National Institute on Drug Abuse (NIDA), Bethesda, MD: National Institute on Drug Abuse (NIDA), 1970

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A poster showing a colorful boardgame.
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The black cover of a book with white text, illustration of cannibis plants, and an inset photograph of cannibas plants.

The Connoisseurs Handbook of Marijuana, William Daniel Drake Jr., San Francisco, CA: Straight Arrow Books, 1971

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The black cover of a book with white text, illustration of cannibis plants, and an inset photograph of cannibas plants.
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A film still showing an opium poppy in a field.

The Distant Drummer: Flowers of Darkness, Airlie Productions, Washington, DC: George Washington University, 1972

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A film still showing an opium poppy in a field.
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First page of a report

Medication Errors in Labor and Delivery: Reducing Maternal and Fetal Harm, Institute for Safe Medication Practices, Harrisburg, PA: Pennsylvania Patient Safety Authority, 2009

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First page of a report
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Diagram of interactions with children, family, and community expanding out from an individual with a substance abuse disorder.

The Ripple Effect: The Impact of the Opioid Epidemic on Children and Families, Suzanne C. Brundage and Carol Levine, New York, NY: United Hospital Fund, 2019

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Diagram of interactions with children, family, and community expanding out from an individual with a substance abuse disorder.
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Document cover page illustrated with DNA diagrams and a photograph of a doctor with a young child.

Drugs Against Cancer: Stories of Discovery and the Quest for a Cure, Kurt W. Kohn, Bethesda, MD: National Cancer Institute (NCI), 2022

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Document cover page illustrated with DNA diagrams and a photograph of a doctor with a young child.
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