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Ankylosing spondylitis is a type of arthritis of the spine. It causes inflammation between your vertebrae, which are the bones that make up your spine, and in the joints between your spine and pelvis. In some people, it can affect other joints.
AS is more common and more severe in men. It often runs in families. The cause is unknown, but it is likely that both genes and factors in the environment play a role.
Early symptoms of AS include back pain and stiffness. These problems often start in late adolescence or early adulthood. Over time, AS can fuse your vertebrae together, limiting movement. Some people have symptoms that come and go. Others have severe, ongoing pain.
A diagnosis of AS is based on your medical history and a physical examination. You may also have imaging or blood tests.
AS has no cure, but medicines can relieve symptoms and may keep the disease from getting worse. Eating a healthy diet, not smoking, and exercising can also help. In rare cases, you may need surgery to straighten the spine.
NIH: National Institute of Arthritis and Musculoskeletal and Skin Disease
- Symptoms of Ankylosing Spondylitis (Spondylitis Association of America)
Treatments and Therapies
- Alternative Treatments for Ankylosing Spondylitis (Spondylitis Association of America)
- Disease Modifying Antirheumatic Drugs (DMARDs) (Beyond the Basics) (UpToDate)
- NSAIDs (Nonsteroidal Anti-inflammatory Drugs) (American College of Rheumatology)
- Genetics Home Reference: ankylosing spondylitis (National Library of Medicine)
Statistics and Research
- Bone Loss in Spondyloarthritis Linked to Protein's Misfolding (National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- Scientists Gain New Insights into Genetic Mechanisms of Ankylosing Spondylitis (National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- ClinicalTrials.gov: Spondylitis, Ankylosing (National Institutes of Health)
Journal ArticlesReferences and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Juvenile Spondyloarthritis (JSpA) (Spondylitis Association of America)
- Spondylitis Web Info for Teens (Spondylitis Association of America)