Charcot-Marie-Tooth DiseaseAlso called: Hereditary motor and sensory neuropathy, Peroneal muscular atrophy
Charcot-Marie-Tooth disease (CMT) is a group of genetic nerve disorders. It is named after the three doctors who first identified it. In the United States, CMT affects about 1 in 2,500 people.
CMT affects your peripheral nerves. Peripheral nerves carry movement and sensation signals between the brain and spinal cord and the rest of the body. Symptoms usually start around the teen years. Foot problems such as high arches or hammertoes can be early symptoms. As CMT progresses, your lower legs may weaken. Later, your hands may also become weak.
Doctors diagnose CMT by doing a neurologic exam, nerve tests, genetic tests, or a nerve biopsy. There is no cure. The disease can be so mild you don't realize you have it or severe enough to make you weak. Physical therapy, occupational therapy, braces and other devices and sometimes surgery can help.
NIH: National Institute of Neurological Disorders and Stroke
- Charcot-Marie-Tooth and Related Diseases (Muscular Dystrophy Association) - PDF Available in Spanish
- Charcot-Marie-Tooth Disease (Mayo Foundation for Medical Education and Research)
- Charcot-Marie-Tooth Disease (National Institute of Neurological Disorders and Stroke) - Short Summary
- Charcot-Marie-Tooth Disease (National Institute of Neurological Disorders and Stroke) Available in Spanish
- Signs and Symptoms (Muscular Dystrophy Association)
Diagnosis and Tests
- Electromyography (EMG) (Mayo Foundation for Medical Education and Research)
- Medical Management (Muscular Dystrophy Association)
- CMT1 (Muscular Dystrophy Association)
- Causes of Charcot-Marie-Tooth Disease (CMT) (Muscular Dystrophy Association)
- Genetics Home Reference: Charcot-Marie-Tooth disease (National Library of Medicine)
- Learning about Charcot-Marie-Tooth Disease (National Human Genome Research Institute)
- ClinicalTrials.gov: Charcot-Marie-Tooth Disease (National Institutes of Health)
Journal ArticlesReferences and abstracts from MEDLINE/PubMed (National Library of Medicine)
- Article: Charcot-Marie-Tooth Disease Type 4H Resulting from Compound Heterozygous Mutations in...
- Article: Charcot-Marie-Tooth disease: New insights from skin biopsy.
- Article: Genotype-phenotype characteristics and baseline natural history of heritable neuropathies caused...
- Charcot-Marie-Tooth Disease -- see more articles
Find an Expert
- Find a Neurologist (American Academy of Neurology)
- National Institute of Neurological Disorders and Stroke Available in Spanish