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Vitamin C (Ascorbic acid)

What is it?

Vitamin C is a vitamin. Some animals can make their own vitamin C, but people must get this vitamin from food and other sources. Good sources of vitamin C are fresh fruits and vegetables, especially citrus fruits. Vitamin C can also be made in a laboratory.

Most experts recommend getting vitamin C from a diet high in fruits and vegetables rather than taking supplements. Fresh-squeezed orange juice or fresh-frozen concentrate is a better pick than ready-to-drink orange juice. The fresh juice contains more active vitamin C. Drink fresh-frozen orange juice within one week after reconstituting it for the most benefit. It you prefer ready-to-drink orange juice, buy it 3 to 4 weeks before the expiration date, and drink it within one week of opening.

Historically, vitamin C was used for preventing and treating scurvy. Scurvy is now relatively rare, but it was once common among sailors, pirates, and others who spent long periods of time onboard ships. When the voyages lasted longer than the supply of fruits and vegetables, the sailors began to suffer from vitamin C deficiency, which led to scurvy.

These days, vitamin C is used most often for preventing and treating the common cold. Some people use it for other infections including gum disease, acne and other skin infections, bronchitis, human immunodeficiency virus (HIV) disease, stomach ulcers caused by bacteria called Helicobacter pylori, tuberculosis, dysentery (an infection of the lower intestine), and skin infections that produce boils (furunculosis). It is also used for infections of the bladder and prostate.

Some people use vitamin C for depression, thinking problems, dementia, Alzheimer's disease, physical and mental stress, fatigue, and attention deficit-hyperactivity disorder (ADHD).

Other uses include increasing the absorption of iron from foods and correcting a protein imbalance in certain newborns (tyrosinemia).

There is some thought that vitamin C might help the heart and blood vessels. It is used for hardening of the arteries, preventing clots in veins and arteries, heart attack, stroke, high blood pressure, and high cholesterol.

Vitamin C is also used for glaucoma, preventing cataracts, preventing gallbladder disease, dental cavities (caries), constipation, Lyme disease, boosting the immune system, heat stroke, hay fever, asthma, bronchitis, cystic fibrosis, infertility, diabetes, chronic fatigue syndrome (CFS), autism, collagen disorders, arthritis and bursitis, back pain and disc swelling, cancer, and osteoporosis.

Additional uses include improving physical endurance and slowing aging, as well as counteracting the side effects of cortisone and related drugs, and aiding drug withdrawal in addiction.

Sometimes, people put vitamin C on their skin to protect it against the sun, pollutants, and other environmental hazards. Vitamin C is also applied to the skin to help with damage from radiation therapy.

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for VITAMIN C (ASCORBIC ACID) are as follows:

Effective for...

  • Vitamin C deficiency. Taking vitamin C by mouth or injecting as a shot prevents and treats vitamin C deficiency, including scurvy. Also, taking vitamin C can reverse problems associated with scurvy.

Likely effective for...

  • Iron absorption. Administering vitamin C along with iron can increase how much iron the body absorbs in adults and children.
  • A genetic disorder in newborns called tyrosinemia. Taking vitamin C by mouth or as a shot improves a genetic disorder in newborns in which blood levels of the amino acid tyrosine are too high.

Possibly effective for...

  • Age-related vision loss (age-related macular degeneration; AMD). Taking vitamin C in combination with zinc, vitamin E, and beta-carotene daily seems to help prevent vision loss or slow the worsening of AMD in patients with advanced AMD. There is not enough evidence to know if this combination helps people with less advanced macular disease or if it prevents AMD. Using vitamin C with other antioxidants, but without zinc, does not seem to have any effect on AMD.
  • Decreasing protein in the urine (albuminuria). Taking vitamin C plus vitamin E can reduce protein in the urine in people with diabetes.
  • Hardening of the arteries (atherosclerosis). Taking vitamin C by mouth seems to decrease the risk of artery hardening. Vitamin C also appears to slow the rate at which artery hardening worsens. More research is needed to understand the effects of vitamin C intake from the diet or supplements on this condition once it has developed.
  • Cancer. Consuming vitamin C in the diet might decrease the risk of developing mouth cancers and other cancers. Some research suggests that increasing vitamin C intake through fruits and vegetables reduces the risk of cancer. However, taking vitamin C supplements does not appear to reduce cancer risk.
  • Common cold. There is some controversy about the effectiveness of vitamin C for treating the common cold. However, the majority of evidence shows that taking high doses of vitamin C might shorten the course of the cold by 1 to 1.5 days in some patients. Taking vitamin C is not effective for preventing the common cold.
  • Chronic pain condition (complex regional pain syndrome). Taking vitamin C after a wrist fracture seems to decrease the risk of developing a chronic pain condition called complex regional pain syndrome.
  • Kidney problems related to contrast media used during a diagnostic test called angiography. Taking vitamin C before and after an angiography seems to reduce the risk of developing kidney problems.
  • Redness (erythema) after cosmetic skin procedures. There is some evidence that using a particular vitamin C skin cream can decrease the amount and duration of skin redness following laser resurfacing for scar and wrinkle removal.
  • Lung infections caused by heavy exercise. Using vitamin C before heavy physical exercise, such as a marathon, might prevent upper respiratory infections that sometimes follow heavy exercise.
  • Gallbladder disease. There is some evidence that taking vitamin C might help to prevent gallbladder disease in women. However, vitamin C does not seem to have this effect in men.
  • Ulcers in the stomach caused by bacteria called H. pylori. Taking vitamin C seems to decrease some of the side effects caused by treatment for H. pylori infections. After H. pylori bacteria are killed, vitamin C appears to decrease the development of precancerous lesions in the stomach. However, other research suggests that vitamin C does not improve healing from H. pylori infection.
  • Abnormal breakdown of red blood cells (hemolytic anemia). Treatment with vitamin C can improve hemolytic anemia.
  • High blood pressure. Taking vitamin C along with conventional blood pressure-lowering medications appears to decrease systolic blood pressure (the top number in a blood pressure reading) by a small amount, but does not seem to decrease diastolic pressure (the bottom number). Taking vitamin C supplements alone does not seem to affect blood pressure.
  • Lead poisoning. Consuming vitamin C in the diet seems to lower blood levels of lead.
  • Helping medicines used for chest pain work longer. Taking vitamin C by mouth seems to help medicines used for chest pain, such as nitroglycerine, work longer.
  • Osteoarthritis. Taking vitamin C from dietary sources or from calcium ascorbate supplements seems to prevent cartilage loss and worsening of symptoms in people with osteoarthritis.
  • Physical performance. Eating more vitamin C as part of the diet might improve physical performance and muscle strength in older people. Also, taking vitamin C supplements might improve oxygen intake during exercise in teenage boys.
  • Sunburn. Taking vitamin C by mouth along with vitamin E seems to prevent sunburn. However, taking vitamin C alone does not prevent sunburn.
  • Wrinkled skin. Skin creams containing vitamin C or vitamin C in combination with acetyl tyrosine, zinc sulfate, sodium hyaluronate, and bioflavonoids (Cellex-C High Potency Serum) seem to improve wrinkles in facial skin that is aged by sun exposure.

Possibly ineffective for...

  • Bronchitis. Taking vitamin C by mouth does not seem to have any effect on bronchitis.
  • Alzheimer's disease and dementia. Vitamin C, consumed as part of the diet, as a supplement, or together with vitamin E, does not seem to reduce the risk of developing Alzheimer’s disease or dementia. However, some research suggests that high, long-term use of vitamin C and E supplements is associated with a reduced risk of Alzheimer’s disease.
  • Eye disease associated with a medicine called interferon. Taking vitamin C daily by mouth does not seem to reduce the risk of eye disease associated with interferon therapy in people with liver disease.
  • Lung cancer. Research suggests that taking vitamin C, alone or together with vitamin C, does not reduce the risk of lung cancer or death due to lung cancer.
  • Death from any cause. Some research suggests that high vitamin C blood levels are associated with a lower risk of death from any cause. However, other research shows that taking vitamin C daily together with vitamin E, beta-carotene, selenium, and zinc does not lower the risk of death. Overall, most research suggests that vitamin C supplements do not reduce the risk of death.
  • Pancreatic cancer. Research shows that taking vitamin C together with beta-carotene plus vitamin E does not reduce the risk of pancreatic cancer.
  • High blood pressure during pregnancy (pre-eclampsia). Some research suggests that taking vitamin C by mouth along with vitamin E seems to prevent high blood pressure during high-risk pregnancies. However, most research shows that taking vitamin C with vitamin E does not reduce the risk of high blood pressure during pregnancy.
  • Complications during pregnancy. Research suggests that taking vitamin C, alone or with vitamin E, does not reduce the risk of complications during pregnancy.
  • Prostate cancer. Research shows that taking a combination of vitamin C, vitamin E, beta-carotene, selenium, and zinc does not reduce the risk of prostate cancer. Overall, most evidence suggests that taking vitamin C supplements does not reduce the risk of developing prostate cancer.
  • Skin problems related to radiation cancer treatments. Applying a vitamin C solution to the skin does not prevent skin problems caused by radiation treatments.
  • Stroke. Most research suggests that taking vitamin C by mouth does not lower the risk for stroke.

Insufficient evidence to rate effectiveness for...

  • Hay fever (Allergic rhinitis). There is conflicting evidence about the effects of vitamin C for improving symptoms of hay fever. Taking vitamin C does not seem to prevent hay fever.
  • Damage to heart caused by the cancer drug anthracycline. Research suggests that taking vitamin C, along with vitamin E and other ingredients, does not reduce the risk of heart damage caused by the cancer drug anthracycline.
  • Stomach damage caused by aspirin. Some research suggests that taking vitamin C might prevent stomach damage caused by aspirin.
  • Asthma. There is some evidence that people with asthma might have low vitamin C levels. However, research suggests that taking vitamin C does not reduce the risk of developing asthma or improve asthma symptoms.
  • Attention deficit-hyperactivity disorder (ADHD). Some evidence suggests that taking high doses of vitamin C does not reduce ADHD symptoms. Other research suggests that taking lower doses of vitamin C might improve some symptoms such as restlessness and self-control in children with ADHD.
  • Autism. Early evidence suggests that taking vitamin C reduces the severity of autism symptoms in children.
  • Bladder cancer. Taking vitamin C does not seem to affect survival from bladder cancer.
  • Breast cancer. Research on the effects of vitamin C for treating breast cancer conflicts. Some research suggests that high vitamin C intake in the diet reduces breast cancer risk, while other research suggests it has no effect. There is no evidence that taking vitamin C supplements reduces the risk of developing breast cancer.
  • Burns. Early evidence suggests that using a vitamin C infusion within the first 24 hours of severe burns reduces wound swelling.
  • Heart disease. Research on the use of vitamin C for heart disease is unclear. More research on the use of vitamin C supplements for preventing heart disease is needed. However, increasing vitamin C intake in the diet might provide some benefit.
  • Cataracts. There is conflicting information about the use of vitamin C to prevent cataracts. Vitamin C plus vitamin E and beta-carotene does not seem to have any significant effect on age-related loss of vision due to cataracts in well-nourished people who take the supplement long-term (for an average of 6.3 years). On the other hand, other research suggests that taking multivitamins that contain vitamin C for 10 years seems to prevent cataracts. Use of supplements for shorter periods does not appear to work.
  • Cervical cancer. Some limited research suggests that taking vitamin C reduces the risk of cervical cancer.
  • Damage to the colon due to radiation exposure (chronic radiation proctitis). Early research suggests that taking vitamin C plus vitamin E might improve some symptoms of chronic radiation proctitis.
  • Colorectal cancer. Taking vitamin C together with vitamin E and beta-carotene does not seem to reduce the risk of colorectal cancer. Vitamin C intake from the diet also does not appear to be linked to colorectal cancer risk.
  • Poor blood circulation in the legs (chronic venous insufficiency). Research suggests that taking a specific product (Cyclo 3 Fort) containing butchers broom extract, hesperidin methyl chalcone, and vitamin C reduces pain, cramps, and other symptoms in people with poor blood circulation in the legs.
  • Dental plaque. Chewing gum containing vitamin C appears to reduce dental plaque.
  • Diabetes. Some research suggests that taking vitamin C decreases blood sugar and cholesterol levels in people with diabetes. However, other research suggests that vitamin C does not improve blood sugar in people with diabetes. Vitamin C does not appear to decrease the risk of developing diabetes.
  • Endometrial cancer. Research suggests that vitamin C intake from the diet slightly lowers the risk of endometrial cancer.
  • Esophageal cancer. Taking vitamin C along with beta-carotene plus vitamin E does not reduce the risk of developing esophageal cancer. However, higher vitamin C intake in the diet appears to be linked to a lower risk of esophageal cancer.
  • Stomach cancer. Not all research agrees on whether or not taking vitamin C supplements or getting extra vitamin C in the diet can prevent stomach cancer. Taking vitamin C supplements in combination with beta-carotene or beta-carotene plus vitamin E does not seem to reduce the risk of stomach cancer. However, some evidence suggests that taking vitamin C alone might keep precancerous sores in the stomach from progressing to cancer in people at high risk for stomach cancer.
  • Gout. Research shows that increased vitamin C intake from the diet is linked to a lower risk of gout in men.
  • HIV/AIDS. Taking vitamin C daily together with vitamin A, beta-carotene, vitamin E, selenium, and coenzyme Q-10 seems to have some benefits for people with HIV/AIDS. However, neither high nor low doses of vitamin C affect how much of the virus is active in the body.
  • HIV transmission. Taking vitamin C along with vitamin B and vitamin E during pregnancy and breast-feeding seems to reduce the risk of transmitting HIV to the infant.
  • High cholesterol. Taking vitamin C daily does not seem to lower cholesterol in people with normal cholesterol levels. However, research suggests that taking vitamin C reduces low-density lipoprotein (LDL or “bad”) cholesterol in people with high cholesterol.
  • Infertility. There is early evidence that women with certain fertility problems might benefit from taking vitamin C daily.
  • Leukemia. There is some evidence that vitamin C might enhance the effects of the drug arsenic trioxide (Trisenox) in people with leukemia.
  • Mental stress. Limited evidence suggests that vitamin C might reduce blood pressure and symptoms during times of mental distress.
  • Liver disease (nonalcoholic steatohepatitis). Early research suggests that taking vitamin C together with vitamin E might improve some aspects of liver function in people with a certain liver disease called nonalcoholic steatohepatitis. However, it does not seem to decrease liver swelling in people with this condition.
  • Osteoporosis. Some evidence suggests that vitamin C might improve bone strength. However, higher vitamin C blood levels in postmenopausal women have been linked to lower bone mineral densities. More information is needed on the effects of vitamin C on bone mineral density.
  • Ovarian cancer. Consuming vitamin C in the diet does not seem to affect the risk of developing ovarian cancer.
  • Parkinson’s disease. Research suggests that increased vitamin C intake in the diet does not reduce the risk of Parkinson’s disease.
  • Pneumonia. Some research suggests that vitamin C might reduce the risk of pneumonia, as well as the duration of pneumonia once it develops.
  • Bed sores (pressure ulcers). Some evidence suggests that taking vitamin C does not improve wound healing in people with pressure ulcers. However, other research suggests that taking vitamin C reduces the size of pressure ulcers.
  • Sickle cell disease. Taking vitamin C with aged garlic extract and vitamin E might benefit people with sickle cell disease.
  • Bacterial infection in the nervous system (tetanus). Some evidence suggests that taking vitamin C daily along with conventional treatment reduces the risk of death in children with tetanus.
  • Urinary tract infections (UTI). Research suggests that taking vitamin C does not prevent UTIs in older people.
  • Kidney disease.
  • Cystic fibrosis.
  • Lyme disease.
  • Chronic fatigue syndrome (CFS).
  • Wounds.
  • Tuberculosis.
  • Dental cavities.
  • Constipation.
  • Acne.
  • Other conditions.
More evidence is needed to rate vitamin C for these uses.

How does it work?

Vitamin C is required for the proper development and function of many parts of the body. It also plays an important role in maintaining proper immune function.

Are there safety concerns?

Vitamin C is LIKELY SAFE for most people when taken by mouth in recommended doses, when applied to the skin, when injected into the muscle, and when injected intravenously (by IV) and appropriately. In some people, vitamin C might cause nausea, vomiting, heartburn, stomach cramps, headache, and other side effects. The chance of getting these side effects increases the more vitamin C you take. Amounts higher than 2000 mg daily are POSSIBLY UNSAFE and may cause a lot of side effects, including kidney stones and severe diarrhea. In people who have had a kidney stone, amounts greater than 1000 mg daily greatly increase the risk of kidney stone recurrence.

Special precautions & warnings:

Pregnancy and breast-feeding: Vitamin C is LIKELY SAFE for pregnant or breast-feeding women when taken by mouth in amounts no greater than 2000 mg daily for women over 19 years-old, and 1800 mg daily for women 14 to 18 years-old, or when given intravenously (by IV) or intramuscularly and appropriately. Taking too much vitamin C during pregnancy can cause problems for the newborn baby. Vitamin C is POSSIBLY UNSAFE when taken by mouth in excessive amounts.

Infants and children: Vitamin C is LIKELY SAFE when taken by mouth appropriately. Vitamin C is POSSIBLY UNSAFE when taken by mouth in amounts higher than 400 mg daily for children 1 to 3 years, 650 mg daily for children 4 to 8 years, 1200 mg daily for children 9 to 13 years, and 1800 mg daily for adolescents 14 to 18 years.

Angioplasty, a heart procedure: Avoid taking supplements containing vitamin C or other antioxidant vitamins (beta-carotene, vitamin E) immediately before and following angioplasty without the supervision of a health care professional. These vitamins seem to interfere with proper healing.

Cancer: Cancerous cells collect high concentrations of vitamin C. Until more is known, only use high doses of vitamin C under the direction of your oncologist.

Diabetes: Vitamin C might raise blood sugar. In older women with diabetes, vitamin C in amounts greater than 300 mg per day increases the risk of death from heart disease. Do not take vitamin C in doses greater than those found in basic multivitamins.

Blood-iron disorders, including conditions called “thalassemia” and “hemochromatosis”: Vitamin C can increase iron absorption, which might make these conditions worse. Avoid large amounts of vitamin C.

Kidney stones, or a history of kidney stones: Large amounts of vitamin C can increase the chance of getting kidney stones. Do not take vitamin C in amounts greater than those found in basic multivitamins.

Heart attack: Vitamin C levels are reduced during a heart attack. However, low vitamin C has not been linked to an increased risk for heart attack.

A metabolic deficiency called “glucose-6-phosphate dehydrogenase” (G6PD) deficiency: Large amounts of vitamin C can cause red blood cells to break in people with this condition. Avoid excessive amounts of vitamin C.

Smoking and chewing tobacco: Smoking and chewing tobacco lowers vitamin C levels. Vitamin C intake in the diet should be increased in people who smoke or chew tobacco.

Sickle cell disease: Vitamin C might make this condition worse. Avoid using large amounts of vitamin C.

Are there interactions with medications?

Be cautious with this combination.
Aluminum is found in most antacids. Vitamin C can increase how much aluminum the body absorbs. However, it is not clear if this interaction is a big concern. Take vitamin C two hours before or four hours after antacids.
The body breaks down estrogens to get rid of them. Vitamin C might decrease how quickly the body gets rid of estrogens. Taking vitamin C along with estrogens might increase the effects and side effects of estrogens.
Fluphenazine (Prolixin)
Large amounts of vitamin C might decrease how much fluphenazine (Prolixin) is in the body. Taking vitamin C along with fluphenazine (Prolixin) might decrease the effectiveness of fluphenazine (Prolixin).
Medications for cancer (Chemotherapy)
Vitamin C is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if this interaction occurs.
Medications used for HIV/AIDS (Protease Inhibitors)
Taking large doses of vitamin C might reduce how much of some medications used for HIV/AIDS stays in the body. This could decrease the effectiveness of some medications used for HIV/AIDS.

Some of these medications used for HIV/AIDS include amprenavir (Agenerase), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Fortovase, Invirase).
Medications used for lowering cholesterol (Statins)
Taking vitamin C, beta-carotene, selenium, and vitamin E together might decrease the effectiveness of some medications used for lowering cholesterol. It is not known if vitamin C alone decreases the effectiveness of some medications used for lowering cholesterol.

Some medications used for lowering cholesterol include atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), and pravastatin (Pravachol).
Taking vitamin C along with vitamin E, beta-carotene, and selenium might decrease some of the helpful effects of niacin. Niacin can increase the good cholesterol. Taking vitamin C along with these other vitamins might decrease the effectiveness of niacin for increasing good cholesterol.
Taking vitamin C with pentobarbital might increase the sedative effects of pentobarbital.
Warfarin (Coumadin)
Warfarin (Coumadin) is used to slow blood clotting. Large amounts of vitamin C might decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Be watchful with this combination.
Acetaminophen (Tylenol, others)
The body breaks down acetaminophen (Tylenol, others) to get rid of it. Large amounts of vitamin C can decrease how quickly the body breaks down acetaminophen. It is not clear exactly when or if this interaction is a big concern.
Aspirin is removed by the body through the kidneys and in the urine. Some scientists have raised concern that vitamin C might decrease how the body removes aspirin and could potentially increase the amount of aspirin in the body. There is concern that this could increase the chance of aspirin-related side effects. However, some research suggests that this is not an important concern and that vitamin C does not interact in a meaningful way with aspirin. Some research actually suggests that taking vitamin C with buffered aspirin might decrease the stomach irritation caused by aspirin. More evidence is needed about this possible benefit.
Choline Magnesium Trisalicylate (Trilisate)
Vitamin C might decrease how quickly the body gets rid of choline magnesium trisalicylate (Trilisate). It is not clear if this interaction is a big concern.
Nicardipine (Cardene)
Vitamin C is taken up by cells. Taking nicardipine (Cardene) along with vitamin C might decrease how much vitamin C is taken in by cells. The significance of this interaction is not clear.
Vitamin C is taken up by cells. Taking nifedipine (Adalat, Procardia) along with vitamin C might decrease how much vitamin C is taken in by cells. The significance of this interaction is not clear.
Salsalate (Disalcid)
Vitamin C might decrease how quickly the body gets rid of salsalate (Disalcid). Taking vitamin C along with salsalate (Disalcid) might cause too much salsalate (Disalcid) in the body, and increase the effects and side effects of salsalate.

Are there interactions with herbs and supplements?

Acerola contains high levels of vitamin C. Don't take large amounts of acerola along with vitamin C. This might give you too much vitamin C. Adults should not take more than 2000 mg vitamin C per day.
Cherokee rosehip
Cherokee rosehip contains high levels of vitamin C. Don't take large amounts of Cherokee rosehip along with vitamin C. This might give you too much vitamin C. Adults should not take more than 2000 mg vitamin C per day.
There is some information that suggests that vitamin C increases chromium absorption. Don't take large doses of chromium and vitamin C together. It isn't known whether separating the doses by several hours avoids this interaction.
High doses of vitamin C (1500 mg daily) can decrease copper levels in the blood in young men. Researchers aren't sure why this happens, but it may be that the acid in vitamin C converts copper to a form that doesn't pass easily from food in the intestine to the bloodstream. Or it may be that vitamin C somehow causes the body to use up copper in the blood. This interaction probably isn't important except in people whose dietary levels of copper is low.
These is early evidence that people with high blood pressure who take both vitamin C 500 mg/day plus grape seed polyphenols 1000 mg/day have significantly increased blood pressure. Researchers aren't sure why this happens.
Vitamin C increases the absorption of iron when taken at the same time. Taking a vitamin C supplement to improve absorption of iron from the diet or from supplements probably isn't necessary for most people, especially if their diet contains plenty of vitamin C.
Rosehip contains high levels of vitamin C. Don't take large amounts of rosehip along with vitamin C. This might give you too much vitamin C. Adults should not take more than 2000 mg vitamin C per day.
Vitamin B12
Early research suggests that vitamin C supplements can destroy vitamin B12 that comes from the diet. However, other ingredients in food, such as iron and nitrates, might counteract this effect. Researchers aren't sure how important this interaction is, but it can likely be avoided if vitamin C supplements are taken at least 2 hours after meals.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

  • For scurvy: 100-250 mg once or twice daily for several days.
  • For treating the common cold: 1-3 grams daily.
  • For preventing kidney damage related to contrast media used during diagnostic tests: vitamin C 3 grams is given before coronary angiography and then 2 grams is given after the procedure in the evening and again the following morning.
  • For slowing progression of hardening of the arteries: slow-release vitamin C 250 mg in combination with 91 mg (136 IU) of vitamin E twice daily for up to 6 years.
  • For tyrosinemia in premature infants on high protein diets: 100 mg of vitamin C.
  • For reducing protein in the urine of patients with type 2 diabetes: vitamin C 1250 mg with vitamin E 680 IU daily for 4 weeks.
  • For preventing complex regional pain syndrome in patients with wrist fractures, vitamin C 500 mg daily for 50 days.
The daily recommended dietary allowances (RDAs) are: Infants 0 to 12 months, human milk content (older recommendations specified 30-35 mg); Children 1 to 3 years, 15 mg; Children 4 to 8 years, 25 mg; Children 9 to 13 years, 45 mg; Adolescents 14 to 18 years, 75 mg for boys and 65 mg for girls; Adults age 19 and greater, 90 mg for men and 75 mg for women; Pregnancy and Lactation: age 18 or younger, 115 mg; ages 19 to 50 years 120 mg. People who use tobacco should take an additional 35 mg per day.
Do not take more than the following amounts of vitamin C: 400 mg per day for children ages 1 to 3 years, 650 mg per day for children 4 to 8 years, 1200 mg per day for children 9 to 13 years, and 1800 mg per day for adolescents and pregnant and breast-feeding women 14 to 18 years, and 2000 mg per day for adults and pregnant and lactating women.

  • Most topical preparations used for aged or wrinkled skin are applied daily. Studies have used creams containing 5% to 10% vitamin C. In one study a specific vitamin C formulation (Cellex-C High Potency Serum) used 3 drops applied daily to areas of facial skin. Don’t apply vitamin C preparations to the eye or eyelids. Also avoid contact with hair or clothes. It can cause discoloration.

Other names

Acide Ascorbique, Acide Cévitamique, Acide Iso-Ascorbique, Acide L-Ascorbique, Acido Ascorbico, Antiscorbutic Vitamin, Ascorbate, Ascorbate de Calcium, Ascorbate de Sodium, Ascorbic acid, Ascorbyl Palmitate, Calcium Ascorbate, Cevitamic Acid, Iso-Ascorbic Acid, L-Ascorbic Acid, Magnesium Ascorbate, Palmitate d'Ascorbyl, Selenium Ascorbate, Sodium Ascorbate, Vitamina C, Vitamine Antiscorbutique, Vitamine C.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


  1. Nyyssonen K, Parviainen MT, Salonen R, Korpela H, Tuomilehto J, and Salonen JT. Vitamin C deficiency is associated with high risk of myocardial infarction in eastern Finnish men. Eur Heart J 1994;15:168.
  2. Results from the Heart Protection Study (HPS). 2001;
  3. Dick EC, Mink KA, Olander D, Schult PA, Jennings LC, Inhorn, and SL. Amelioration of rhinovirus type 16 (RV 16) colds in ascorbic acid supplemented volunteers. 30th ICAAC Proceedings 1990;
  4. Leydhecker W. Zur medicamento¨sen Behandlung der Diabetischen Retinopathie. of the University Clinic of Wurzburg, Wurzburg, Germany 1986;
  5. Evans G. The effect of chromium picolinate on insulin controlled parameters in humans. Int.J.Biosoc.Med.Res 1989;11:163-180.
  6. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, and Voorhees JJ. Topical tretinoin improves photo-aged skin. A double-blind vehicle-controlled study. JAMA 1988;259:527-532.
  7. Number of CARET participants with cancer endpoints by cancer type and intervention arm assignment. 2007;
  8. Norris JR and Reynolds RE. The effect of oral zinc sulfate therapy on decubitus ulcers. J Am Geriatr Soc 1971;19:793-797.
  9. Chernoff RS, Milton KY, and Lipschitz DA. The effect of a very high-protein liquid formula on decubitus ulcers healing in long-term tube-fed institutionalized patients. J Am Diet Assoc 1990;90:A-130.
  10. Taghriri A and Danesh A. Effects of vitamins E and C in reduction of preeclampsia blood pressure incidence in primigravids. Shahrekord Univ Med Sci J 2007;1:50-54.
  11. Nasrolahi SH, Ali mohammadi SH, and Zamani M. The effect of antioxidants (Vitamin E & C) on preeclampsia in primipar women. J Gorgan Univ Med Sci 2006;17:17-21.
  12. Correia JM, Silva Cruz A, and Silva Meirinho M. The importance of the contribution of folic acid in gestation. Progresos de Obstetricia y Ginecologia 1982;25:381-386.
  13. Rivas-Echeverria CA, Echeverria Y, Molina L, and Novoa D. Synergic use of aspirin, fish oil and vitamins C and E for the prevention of preeclampsia. Hypertension in Pregnancy 2000;19(Suppl 1):30.
  14. Mahdy ZA, Siraj HH, Azwar MH, Wahab MA, Khaza'ai H, and Mutalib MSA. The role of palm oil vitamin E in the prevention of pregnancy-induced hypertension. Hypertension in Pregnancy 2004;23(Suppl 1):67.
  15. Villar J, Purwar M Merialdi M Zavaleta N Ngoc N Anthony J et al. Effect of vitamin C &E supplementation of pregnant women at risk of preeclampsia plus low nutritional status: the WHO trial. Hypertension in Pregnancy 2008;27:501.
  16. Elliott B. Ascorbic acid: efficacy in the prevention of symptoms of respiratory infection on a Polaris submarine. IRCS J Int Res Commun/Med Sci 1973;1:12.
  17. Wenzel G, Kuklinski B, Ruhlmann C, and Ehrhardt D. Alkoholtoxische Hepatitis-eine "freie Radikale" assoziierte Erkrankung Letalitatssenkung durch adjuvante Antioxidantientherapie. Z Gesamte Inn Med 1993;48:490-496.
  18. Burns, A Marsh A Bender DA. A trial of vitamin supplementation in senile dementia. International Journal of Geriatric Psychiatry 1989;4:333-338.
  19. Manson JE, Stampfer MJ, Wiiiett WC, Coiditz GA, Rosner B, and Speizer FE. A prospective study of vitamin C and incidence of coronary heart disease in women. Circulation 1992;85:865.
  20. Jacques PF. Effect of vitamin C on high density lipo- protein cholesterol and blood pressure. J Am Coll Nutr 2011;11:139-144.
  21. Choi ESK, Jacques PF, Dallal GE, and Jacob RA. Correlation of blood pressure with plasma ascorbic acid. Nutr Res 1991;11:1377-1382.
  22. Koh ET and Chi MS. Relationship of serum vitamin C and globulin fractions with anthropometric measurements in adults. Nutr Rep Int 1980;21:537-549.
  23. Koh ET and Stewart T. Interrelationship among the blood components and anthropometric measurements. Rep Int 1978;18:539-549.
  24. Salonen JT. Blood pressure, dietary fats, and oxidants. Am J Clin Nutr 1988;48:1226-1232.
  25. Salonen R, Korpela H Nyysso nen K Porkkala E Salonen JT. Reduction of blood pressure by antioxidant supplementation: a randomised double-blind clinical trial. Life Chem Rep 1994;12:65-68.
  26. Farvid M, Homayoni F Neyestani T Amiri Z. Blood pressure lowering effects of micronutrients in type 2 diabetic patients. Iran J Endocrinology Metab 2010;12
  27. Block G, Dietrich M Norkus EP. Effect of antioxidant supplementation on blood pressure: a randomized trial. Am J Epidemiol 2002;11:S22.
  28. Osilesi O, Trout DL, Ogunwole JO, and Glover EE. Blood pressure and plasma lipids during ascorbic acid supplementation in borderline hypertensive and normotensive adults. Nutr Res 1991;11:405-412.
  29. Mamianetti A, Vescina MC, Matejka MA, Alvarez O, Dameno E, and Carducci CN. Efecto del acido ascorbico sobre los lipidos biliares en pacientes litiasicos. Prensa Med Argent 1988;75:346-350.
  30. Gulenc S and Nebioglu S. Oral yolla askorbik asit alan kisilerde sigara kullanimmina bagli serum trigliserit, total kolesterol ve HDLkolesterol duzeyleri. FABAD J Pharm Sci 1988;13:493-499.
  31. Heine H and Norden C. Vitamin C therapy in hyperlipoproteinemia. Int J Vitam Nutr Res 1979;19:45-54.
  32. Filho RL, Lima MB, Kneipp R, Cunha LC, and Ogliari M. Alteracoes dos niveis sericos de cholesterol, em pacientes sob o uso de acido ascorbico. Folha Medica 1978;77:451-454.
  33. Hanck A and Weiser H. Vitamin C and lipid metabolism. Int J Vitam Nutr Res 1977;16:67-81.
  34. Gurler B, Vural H, and Yilmaz N. The role of oxidative stress in diabetic retinopathy. Eye 2000;14:730-735.
  35. Bonelli L, Camoriano A, Ravelli P, Missale G, Bruzzi P, and Aste H. Reduction of the incidence of metachronous adenomas of the large bowel by means of antioxidants. Proceedings of International Selenium Tellurium Development Association 1998;91-94.
  36. Goel S, Agarwal SB, Mandal AK, Singhal K, and Agarwal T. Emerging role of ascorbic acid in the management of advanced breast carcinoma as a chemosensitizer. Asian J Surg 1999;22:333-336.
  37. Burge PD and Gilbert SJ. Effect of a histamine H2-receptor antagonsist on the swelling of the burned hand. Burns 1979;6:30-32.
  38. Omar MT, El-Badawy AM, Borhan WH, and Nossier AA. Improvement of edema and hand function in superficial second degree hand burn using electrical stimulation. Egypt J Plast Reconstr Surg 2004;28:141-147.
  39. Molnar JA, Heimbach DM, and Tredget EE. Prospective randomized controlled mulitcenter trial applying subatmospheric pressure to acute hand burns: an interim report. 2004;
  40. Hozyasz KK, Chelchowska M, and Milanovski A. Plasma retinol concentration in atopic dermatitis patients with alpha-tocopherol deficiency. Pediatr Pol 2005;80:6-7.
  41. Ermis B, Armutcu F, Gurel A, Kart L, Demircan N, and Altin R. Trace elements status in children with bronchial asthma. Eur J Gen Med 2004;1:4-8.
  42. O'Sullivan S, Doyle S, Cormican L, Gunaratnam C, Poulter LW, and Burke CM. Attenuation of bronchial hyperresponsiveness to histamine by vitamin C in asthmatic subjects. Am J Resp and Crit Care Med 2000;161(3 Suppl):A106.
  43. Link P and Dreher R. D-alpha-tocopherolacetat versus Diclofena-Na in der Therapie der aktivierten Arthrose. Der Kassenarzt 1990;22:48-52.
  44. Klein KG and Blankenhorn G. Vergleich der klinischeen Wirksamkeit von Vitamin E und Diclofenac-Natrium bei Spondylitis ankylosans. Vitamine, Mineralstoffe, Spurenelemente 1987;2:137-142.
  45. Brabant T and Wittenborg A. Anti-phlogistical and analgetical effectivity of vitamin E (d-alpha-tocopherol acetate, spondyvite) in comparison to Diclofenac-sodium in the treatment of patients with chronic arthritis. Zeitschrift fur Rheumatologie 1993;52:356.
  46. Springer D. Rheumatoide Arthritis: Hochdosiertes Vitamin E zeigt analgetischen Effekt. Natura Med 2011;13:30-32.
  47. Jantti J, Vapaatalo H, Seppala E, Ruutsalo HM, and Isomaki H. Treatment of rheumatoid arthritis with fish oil, selenium, vitamins A and E, and placebo. Scand J Rheumatol 1991;20:225.
  48. Semba RD, Muhilal, and West KP. Impact of vitamin A supplementation on hematological indicators of iron metabolism and protein status in children. Nutr Res 1992;12:469-478.
  49. Kolarz G, Scherak O, Shohoumi MEL, and Blankenthorn G. Hochdosiertes Vitamin E bei chronischer Polyarthritis. Aktuelle Rheumatologie 1990;15:233-237.
  50. Chong EW, Robman LD, and Simpson JA. The Associations of Dietary Lutein, Zeaxanthin and Fats with Age-Related Macular Degeneration : The Melbourne Collaborative Cohort Study. Program and abstracts of the Association for Research in Vision and Ophthalmology 2006;
  51. Wang H, Li R-X, and Wang M-F. Effects of zinc and antioxidant on visual function of patients with age-related macular degeneration. Zhongguo Linchuant Kangfu 2004;8:1290-1291.
  52. Holz FG, Wolfensberger TJ, Piguet B, Gross-Jendroska M, Arden GB, and Bird AC. Oral zinc-therapy in age-related macular degeneration: a double-blind study. Ger J Ophthalmol 1993;2:391.
  53. Sabiston BH and Radomski MW. Health Problems and Vitamin C in Canadian Northern Military Operations. 1974;74-R-1012
  54. Peters EM, Goetzsche JM, Joseph LE, and Noakes TD. Vitamin C as effective as combinations of anti-oxidant nutrients in reducing symptoms of upper respiratory tract infection in ultramarathon runners. South Afr J Sports Med 1996;4:23-27.
  55. Moolla, ME. The effect of supplemental anti-oxidants on the incidence and severity of upper respiratory infections in Ultra Marathon runners. 1996;
  56. Himmelstein, S, Robergs R, Koehler K, Lewis S, and Qualls C. Vitamin C supplementation and upper respiratory tract infections in marathon runners. J Exerc Physiol 1998;1:1-17.
  57. Dahlberg G, Engel A, and Rydin H. The value of ascorbic acid as a prophylactic against common colds. Acta Med Scand 1944;119:540-561.
  58. Cowan D, Diehl HS, and Baker AB. Vitamins for the prevention of colds. JAMA 1942;120:1268-1271.
  59. Briggs M. Vitamin C and infectious disease: a review of the literature and the results of a randomised double blind prospective study over eight years. Recent Vitamin Research 1984;39-82.
  60. Kalman, Douglas S. Lou Lidia Schwartz Howard I. Feldman Samantha and Krieger Diane R. A pilot trial comparing the availability of vitamins C, B6, and B12 from a vitamin-fortified water and food source in humans. International Journal of Food Sciences and Nutrition. 2009;60(s5):114-124.
  61. Anderson, C., Checkoway, H., Franklin, G. M., Beresford, S., Smith-Weller, T., and Swanson, P. D. Dietary factors in Parkinson's disease: the role of food groups and specific foods. Mov Disord. 1999;14:21-27. View abstract.
  62. Fahey, T., Stocks, N., and Thomas, T. Systematic review of the treatment of upper respiratory tract infection. Arch.Dis.Child 1998;79:225-230. View abstract.
  63. D'Agostino, R. B., Sr., Weintraub, M., Russell, H. K., Stepanians, M., D'Agostino, R. B., Jr., Cantilena, L. R., Jr., Graumlich, J. F., Maldonado, S., Honig, P., and Anello, C. The effectiveness of antihistamines in reducing the severity of runny nose and sneezing: a meta-analysis. Clin.Pharmacol.Ther. 1998;64:579-596. View abstract.
  64. Mayer-Davis, E. J., Bell, R. A., Reboussin, B. A., Rushing, J., Marshall, J. A., and Hamman, R. F. Antioxidant nutrient intake and diabetic retinopathy: the San Luis Valley Diabetes Study. Ophthalmology 1998;105:2264-2270. View abstract.
  65. Wittenborg, A., Petersen, G., Lorkowski, G., and Brabant, T. [Effectiveness of vitamin E in comparison with diclofenac sodium in treatment of patients with chronic polyarthritis]. Z.Rheumatol. 1998;57:215-221. View abstract.
  66. Hu, G., Zhang, X., Chen, J., Peto, R., Campbell, T. C., and Cassano, P. A. Dietary vitamin C intake and lung function in rural China. Am.J Epidemiol. 9-15-1998;148:594-599. View abstract.
  67. Willems, D., Dorchy, H., and Dufrasne, D. Serum antioxidant status and oxidized LDL in well-controlled young type 1 diabetic patients with and without subclinical complications. Atherosclerosis 1998;137 Suppl:S61-S64. View abstract.
  68. Mendelsohn, A. B., Belle, S. H., Stoehr, G. P., and Ganguli, M. Use of antioxidant supplements and its association with cognitive function in a rural elderly cohort: the MoVIES Project. Monongahela Valley Independent Elders Survey. Am.J Epidemiol. 7-1-1998;148:38-44. View abstract.
  69. Grievink, L., Smit, H. A., Ocke, M. C., Van, 't, V, and Kromhout, D. Dietary intake of antioxidant (pro)-vitamins, respiratory symptoms and pulmonary function: the MORGEN study. Thorax 1998;53:166-171. View abstract.
  70. Thibault, P. K., Wlodarczyk, J., and Wenck, A. A double-blind randomized clinical trial on the effectiveness of a daily glycolic acid 5% formulation in the treatment of photoaging. Dermatol.Surg. 1998;24:573-577. View abstract.
  71. Davidsson, L., Walczyk, T., Morris, A., and Hurrell, R. F. Influence of ascorbic acid on iron absorption from an iron-fortified, chocolate-flavored milk drink in Jamaican children. Am.J Clin.Nutr. 1998;67:873-877. View abstract.
  72. Bandera, E. V., Freudenheim, J. L., Marshall, J. R., Zielezny, M., Priore, R. L., Brasure, J., Baptiste, M., and Graham, S. Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control 1997;8:828-840. View abstract.
  73. Lonn, E. M. and Yusuf, S. Is there a role for antioxidant vitamins in the prevention of cardiovascular diseases? An update on epidemiological and clinical trials data. Can.J Cardiol. 1997;13:957-965. View abstract.
  74. Goodman, M. T., Hankin, J. H., Wilkens, L. R., Lyu, L. C., McDuffie, K., Liu, L. Q., and Kolonel, L. N. Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 11-15-1997;57:5077-5085. View abstract.
  75. Nieman, D. C., Henson, D. A., Butterworth, D. E., Warren, B. J., Davis, J. M., Fagoaga, O. R., and Nehlsen-Cannarella, S. L. Vitamin C supplementation does not alter the immune response to 2.5 hours of running. Int J Sport Nutr 1997;7:173-184. View abstract.
  76. Ness, A. R., Chee, D., and Elliott, P. Vitamin C and blood pressure--an overview. J Hum Hypertens. 1997;11:343-350. View abstract.
  77. Cook, D. G., Carey, I. M., Whincup, P. H., Papacosta, O., Chirico, S., Bruckdorfer, K. R., and Walker, M. Effect of fresh fruit consumption on lung function and wheeze in children. Thorax 1997;52:628-633. View abstract.
  78. Ross, R. K., Yuan, J. M., Henderson, B. E., Park, J., Gao, Y. T., and Yu, M. C. Prospective evaluation of dietary and other predictors of fatal stroke in Shanghai, China. Circulation 7-1-1997;96:50-55. View abstract.
  79. Samman, S., Brown, A. J., Beltran, C., and Singh, S. The effect of ascorbic acid on plasma lipids and oxidisability of LDL in male smokers. Eur.J Clin.Nutr 1997;51:472-477. View abstract.
  80. Kallner, A. Serum bile acids in man during vitamin C supplementation and restriction. Acta Med Scand. 1977;202:283-287. View abstract.
  81. Tsubono, Y., Okubo, S., Hayashi, M., Kakizoe, T., and Tsugane, S. A randomized controlled trial for chemoprevention of gastric cancer in high-risk Japanese population; study design, feasibility and protocol modification. Jpn.J Cancer Res 1997;88:344-349. View abstract.
  82. Gustafsson, U., Wang, F. H., Axelson, M., Kallner, A., Sahlin, S., and Einarsson, K. The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time. Eur.J Clin.Invest 1997;27:387-391. View abstract.
  83. Galley, H. F., Thornton, J., Howdle, P. D., Walker, B. E., and Webster, N. R. Combination oral antioxidant supplementation reduces blood pressure. Clin.Sci (Lond) 1997;92:361-365. View abstract.
  84. Zhang, Z. F., Kurtz, R. C., Yu, G. P., Sun, M., Gargon, N., Karpeh, M., Jr., Fein, J. S., and Harlap, S. Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutr Cancer 1997;27:298-309. View abstract.
  85. Scheider, W. L., Hershey, L. A., Vena, J. E., Holmlund, T., Marshall, J. R., and Freudenheim. Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease. Mov Disord. 1997;12:190-196. View abstract.
  86. Ludvigsson, J., Hansson, L. O., and Tibbling, G. Vitamin C as a preventive medicine against common colds in children. Scand.J Infect.Dis. 1977;9:91-98. View abstract.
  87. Kromhout, D., Bloemberg, B. P., Feskens, E. J., Hertog, M. G., Menotti, A., and Blackburn, H. Alcohol, fish, fibre and antioxidant vitamins intake do not explain population differences in coronary heart disease mortality. Int J Epidemiol. 1996;25:753-759. View abstract.
  88. Dow, L., Tracey, M., Villar, A., Coggon, D., Margetts, B. M., Campbell, M. J., and Holgate, S. T. Does dietary intake of vitamins C and E influence lung function in older people? Am.J Respir.Crit Care Med 1996;154:1401-1404. View abstract.
  89. Tzonou, A., Lipworth, L., Garidou, A., Signorello, L. B., Lagiou, P., Hsieh, C., and Trichopoulos, D. Diet and risk of esophageal cancer by histologic type in a low-risk population. Int J Cancer 11-4-1996;68:300-304. View abstract.
  90. Ness, A. R., Khaw, K. T., Bingham, S., and Day, N. E. Vitamin C status and respiratory function. Eur.J Clin.Nutr 1996;50:573-579. View abstract.
  91. Sano, M., Ernesto, C., Klauber, M. R., Schafer, K., Woodbury, P., Thomas, R., Grundman, M., Growdon, J., and Thal, L. J. Rationale and design of a multicenter study of selegiline and alpha-tocopherol in the treatment of Alzheimer disease using novel clinical outcomes. Alzheimer's Disease Cooperative Study. Alzheimer Dis.Assoc.Disord. 1996;10:132-140. View abstract.
  92. Christen, W. G., Glynn, R. J., Manson, J. E., Ajani, U. A., and Buring, J. E. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA 10-9-1996;276:1147-1151. View abstract.
  93. No author. Multicenter ophthalmic and nutritional age-related macular degeneration study--part 1: design, subjects and procedures. Age-related Macular Degeneration Study Group. J Am.Optom.Assoc. 1996;67:12-29. View abstract.
  94. Ginter, E., Cerna, O., Budlovsky, J., Balaz, V., Hruba, F., Roch, V., and Sasko, E. Effect of ascorbic acid on plasma cholesterol in humans in a long-term experiment. Int J Vitam.Nutr Res 1977;47:123-134. View abstract.
  95. Gatto, L. M., Hallen, G. K., Brown, A. J., and Samman, S. Ascorbic acid induces a favorable lipoprotein profile in women. J Am Coll Nutr 1996;15:154-158. View abstract.
  96. Ness, A. R., Khaw, K. T., Bingham, S., and Day, N. E. Vitamin C status and blood pressure. J Hypertens. 1996;14:503-508. View abstract.
  97. Kaiser, H. J., Flammer, J., Stumpfig, D., and Hendrickson, P. Visaline in the treatment of age-related macular degeneration: a pilot study. Ophthalmologica 1995;209:302-305. View abstract.
  98. Nunez, C., Carbajal, A., Belmonte, S., Moreiras, O., and Varela, G. [A case control study of the relationship between diet and breast cancer in a sample from 3 Spanish hospital populations. Effects of food, energy and nutrient intake]. Rev Clin.Esp. 1996;196:75-81. View abstract.
  99. Kaiser, L., Lew, D., Hirschel, B., Auckenthaler, R., Morabia, A., Heald, A., Benedict, P., Terrier, F., Wunderli, W., Matter, L., Germann, D., Voegeli, J., and Stalder, H. Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. Lancet 6-1-1996;347:1507-1510. View abstract.
  100. Morens, D. M., Grandinetti, A., Waslien, C. I., Park, C. B., Ross, G. W., and White, L. R. Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake. Neurology 1996;46:1270-1274. View abstract.
  101. Paolisso, G., Balbi, V., Volpe, C., Varricchio, G., Gambardella, A., Saccomanno, F., Ammendola, S., Varricchio, M., and D'Onofrio, F. Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. J Am.Coll.Nutr 1995;14:387-392. View abstract.
  102. Toohey, L., Harris, M. A., Allen, K. G., and Melby, C. L. Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African-Americans. J Nutr 1996;126:121-128. View abstract.
  103. Ambrosone, C. B., Marshall, J. R., Vena, J. E., Laughlin, R., Graham, S., Nemoto, T., and Freudenheim, J. L. Interaction of family history of breast cancer and dietary antioxidants with breast cancer risk (New York, United States). Cancer Causes Control 1995;6:407-415. View abstract.
  104. Eriksson, J. and Kohvakka, A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann.Nutr Metab 1995;39:217-223. View abstract.
  105. ter Riet, G., Kessels, A. G., and Knipschild, P. G. Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. J Clin.Epidemiol. 1995;48:1453-1460. View abstract.
  106. Takamatsu, S., Takamatsu, M., Satoh, K., Imaizumi, T., Yoshida, H., Hiramoto, M., Koyama, M., Ohgushi, Y., and Mizuno, S. Effects on health of dietary supplementation with 100 mg d-alpha-tocopheryl acetate, daily for 6 years. J Int Med Res 1995;23:342-357. View abstract.
  107. Rema, M., Mohan, V., Bhaskar, A., and Shanmugasundaram, K. R. Does oxidant stress play a role in diabetic retinopathy? Indian J Ophthalmol. 1995;43:17-21. View abstract.
  108. Portal, B., Richard, M. J., Ducros, V., Aguilaniu, B., Brunel, F., Faure, H., Gout, J. P., Bost, M., and Favier, A. Effect of double-blind crossover selenium supplementation on biological indices of selenium status in cystic fibrosis patients. Clin.Chem. 1993;39:1023-1028. View abstract.
  109. Kabat, G. C., Ng, S. K., and Wynder, E. L. Tobacco, alcohol intake, and diet in relation to adenocarcinoma of the esophagus and gastric cardia. Cancer Causes Control 1993;4:123-132. View abstract.
  110. Moran, J. P., Cohen, L., Greene, J. M., Xu, G., Feldman, E. B., Hames, C. G., and Feldman, D. S. Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am.J Clin.Nutr 1993;57:213-217. View abstract.
  111. Lovat, L. B., Lu, Y., Palmer, A. J., Edwards, R., Fletcher, A. E., and Bulpitt, C. J. Double-blind trial of vitamin C in elderly hypertensives. J Hum Hypertens. 1993;7:403-405. View abstract.
  112. Martinoli, L., Di, Felice M., Seghieri, G., Ciuti, M., De Giorgio, L. A., Fazzini, A., Gori, R., Anichini, R., and Franconi, F. Plasma retinol and alpha-tocopherol concentrations in insulin-dependent diabetes mellitus: their relationship to microvascular complications. Int J Vitam.Nutr Res 1993;63:87-92. View abstract.
  113. Bostick, R. M., Potter, J. D., McKenzie, D. R., Sellers, T. A., Kushi, L. H., Steinmetz, K. A., and Folsom, A. R. Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study. Cancer Res 9-15-1993;53:4230-4237. View abstract.
  114. Potischman, N., Swanson, C. A., Brinton, L. A., McAdams, M., Barrett, R. J., Berman, M. L., Mortel, R., Twiggs, L. B., Wilbanks, G. D., and Hoover, R. N. Dietary associations in a case-control study of endometrial cancer. Cancer Causes Control 1993;4:239-250. View abstract.
  115. Tzonou, A., Kalandidi, A., Trichopoulou, A., Hsieh, C. C., Toupadaki, N., Willett, W., and Trichopoulos, D. Diet and coronary heart disease: a case-control study in Athens, Greece. Epidemiology 1993;4:511-516. View abstract.
  116. Dolske, M. C., Spollen, J., McKay, S., Lancashire, E., and Tolbert, L. A preliminary trial of ascorbic acid as supplemental therapy for autism. Prog.Neuropsychopharmacol.Biol.Psychiatry 1993;17:765-774. View abstract.
  117. Artaud-Wild, S. M., Connor, S. L., Sexton, G., and Connor, W. E. Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in France and Finland. A paradox. Circulation 1993;88:2771-2779. View abstract.
  118. Munoz, J. A., Garcia, C., Quilez, J. L., and Andugar, M. A. Effect of vitamin C on lipoproteins in healthy adults. Ann.Med Interne (Paris) 1994;145:13-19. View abstract.
  119. Peters, E. M., Goetzsche, J. M., Grobbelaar, B., and Noakes, T. D. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am.J Clin.Nutr 1993;57:170-174. View abstract.
  120. Crawford, G. P., Warlow, C. P., Bennett, B., Dawson, A. A., Douglas, A. S., Kerridge, D. F., and Ogston, D. The effeCt of vitamin c supplements on serum cholesterol, coagulation, fibrinolysis and platelet adhesiveness. Atherosclerosis 1975;21:451-454. View abstract.
  121. Ghosh, S. K., Ekpo, E. B., Shah, I. U., Girling, A. J., Jenkins, C., and Sinclair, A. J. A double-blind, placebo-controlled parallel trial of vitamin C treatment in elderly patients with hypertension. Gerontology 1994;40:268-272. View abstract.
  122. Hensrud, D. D., Heimburger, D. C., Chen, J., and Parpia, B. Antioxidant status, erythrocyte fatty acids, and mortality from cardiovascular disease and Keshan disease in China. Eur.J Clin.Nutr 1994;48:455-464. View abstract.
  123. Qi, X. Y., Zhang, A. Y., Wu, G. L., and Pang, W. Z. The association between breast cancer and diet and other factors. Asia Pac.J Public Health 1994;7:98-104. View abstract.
  124. Shaw, R., Woodman, K., Crane, J., Moyes, C., Kennedy, J., and Pearce, N. Risk factors for asthma symptoms in Kawerau children. N.Z.Med J 10-12-1994;107:387-391. View abstract.
  125. Shahar, E., Folsom, A. R., Melnick, S. L., Tockman, M. S., Comstock, G. W., Shimakawa, T., Higgins, M. W., Sorlie, P. D., and Szklo, M. Does dietary vitamin A protect against airway obstruction? The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Am.J Respir.Crit Care Med 1994;150:978-982. View abstract.
  126. Elwood, P. C., Lee, H. P., St Leger, A. S., Baird, M., and Howard, A. N. A randomized controlled trial of vitamin C in the prevention and amelioration of the common cold. Br J Prev.Soc.Med 1976;30:193-196. View abstract.
  127. Coulehan, J. L., Eberhard, S., Kapner, L., Taylor, F., Rogers, K., and Garry, P. Vitamin C and acute illness in Navajo school children. N.Engl.J Med. 10-28-1976;295:973-977. View abstract.
  128. Bellizzi, M. C., Franklin, M. F., Duthie, G. G., and James, W. P. Vitamin E and coronary heart disease: the European paradox. Eur.J Clin.Nutr 1994;48:822-831. View abstract.
  129. Hunt, C., Chakravorty, N. K., Annan, G., Habibzadeh, N., and Schorah, C. J. The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. Int J Vitam.Nutr Res 1994;64:212-219. View abstract.
  130. Yuan, J. M., Wang, Q. S., Ross, R. K., Henderson, B. E., and Yu, M. C. Diet and breast cancer in Shanghai and Tianjin, China. Br J Cancer 1995;71:1353-1358. View abstract.
  131. Britton, J. R., Pavord, I. D., Richards, K. A., Knox, A. J., Wisniewski, A. F., Lewis, S. A., Tattersfield, A. E., and Weiss, S. T. Dietary antioxidant vitamin intake and lung function in the general population. Am.J Respir.Crit Care Med 1995;151:1383-1387. View abstract.
  132. Jacques, P. F., Sulsky, S. I., Perrone, G. E., Jenner, J., and Schaefer, E. J. Effect of vitamin C supplementation on lipoprotein cholesterol, apolipoprotein, and triglyceride concentrations. Ann.Epidemiol. 1995;5:52-59. View abstract.
  133. Barefoot, J. C., Larsen, S., von der, Lieth L., and Schroll, M. Hostility, incidence of acute myocardial infarction, and mortality in a sample of older Danish men and women. Am.J Epidemiol. 9-1-1995;142:477-484. View abstract.
  134. RITZEL, G. Letter: Ascorbic acid and the common cold. JAMA 3-15-1976;235:1108. View abstract.
  135. Wang, H., Zhang, Z. B., Wen, R. R., and Chen, J. W. Experimental and clinical studies on the reduction of erythrocyte sorbitol-glucose ratios by ascorbic acid in diabetes mellitus. Diabetes Res Clin.Pract. 1995;28:1-8. View abstract.
  136. Reaven, P. D., Herold, D. A., Barnett, J., and Edelman, S. Effects of Vitamin E on susceptibility of low-density lipoprotein and low-density lipoprotein subfractions to oxidation and on protein glycation in NIDDM. Diabetes Care 1995;18:807-816. View abstract.
  137. Anah, C. O., Jarike, L. N., and Baig, H. A. High dose ascorbic acid in Nigerian asthmatics. Trop.Geogr.Med 1980;32:132-137. View abstract.
  138. Bordia, A. K. The effect of vitamin C on blood lipids, fibrinolytic activity and platelet adhesiveness in patients with coronary artery disease. Atherosclerosis 1980;35:181-187. View abstract.
  139. Joshi, V. D., Joshi, L. N., and Gokhale, L. V. Effect of ascorbic acid on total and high density lipoprotein cholesterol of plasma in normal human subjects. Indian J Physiol Pharmacol. 1981;25:348-350. View abstract.
  140. Johnson, G. E. and Obenshain, S. S. Nonresponsiveness of serum high-density lipoprotein-cholesterol to high dose ascorbic acid administration in normal men. Am.J Clin.Nutr 1981;34:2088-2091. View abstract.
  141. Khan, A. R. and Seedarnee, F. A. Effect of ascorbic acid on plasma lipids and lipoproteins in healthy young women. Atherosclerosis 1981;39:89-95. View abstract.
  142. Horsey, J., Livesley, B., and Dickerson, J. W. Ischaemic heart disease and aged patients: effects of ascorbic acid on lipoproteins. J Hum Nutr 1981;35:53-58. View abstract.
  143. Burr, M. L., Lennings, C. I., and Milbank, J. E. The prognostic significance of weight and of vitamin C status in the elderly. Age Ageing 1982;11:249-255. View abstract.
  144. Taylor, D. J., Mallen, C., McDougall, N., and Lind, T. Effect of iron supplementation on serum ferritin levels during and after pregnancy. Br J Obstet Gynaecol 1982;89:1011-1017. View abstract.
  145. Keith, R. E. and Driskell, J. A. Lung function and treadmill performance of smoking and nonsmoking males receiving ascorbic acid supplements. Am J Clin.Nutr 1982;36:840-845. View abstract.
  146. Wahlberg, G. and Walldius, G. Lack of effect of ascorbic acid on serum lipoprotein concentrations in patients with hypertriglyceridaemia. Atherosclerosis 1982;43(2-3):283-288. View abstract.
  147. Schachter, E. N. and Schlesinger, A. The attenuation of exercise-induced bronchospasm by ascorbic acid. Ann.Allergy 1982;49:146-151. View abstract.
  148. Stanton, J. L., Braitman, L. E., Riley, A. M., Jr., Khoo, C. S., and Smith, J. L. Demographic, dietary, life style, and anthropometric correlates of blood pressure. Hypertension 1982;4(5 Pt 2):III135-III142. View abstract.
  149. Graham, S., Marshall, J., Mettlin, C., Rzepka, T., Nemoto, T., and Byers, T. Diet in the epidemiology of breast cancer. Am.J Epidemiol. 1982;116:68-75. View abstract.
  150. Buzzard, I. M., McRoberts, M. R., Driscoll, D. L., and Bowering, J. Effect of dietary eggs and ascorbic acid on plasma lipid and lipoprotein cholesterol levels in healthy young men. Am.J Clin.Nutr 1982;36:94-105. View abstract.
  151. Weininger, J. and King, J. C. Effect of oral contraceptive agents on ascorbic acid metabolism in the rhesus monkey. Am.J Clin.Nutr 1982;35:1408-1416. View abstract.
  152. Carr, A. B., Einstein, R., Lai, L. Y., Martin, N. G., and Starmer, G. A. Vitamin C and the common cold: a second MZ Cotwin control study. Acta Genet.Med Gemellol.(Roma.) 1981;30:249-255. View abstract.
  153. Carr, A. B., Martin, N. G., and Whitfield, J. B. Usefulness of the co-twin control design in investigations as exemplified in a study of effects of ascorbic acid on laboratory test results. Clin.Chem. 1981;27:1469-1470. View abstract.
  154. Smogorzewska, E. M., Layward, L., and Soothill, J. F. T lymphocyte mobility: defects and effects of ascorbic acid, histamine and complexed IgG. Clin.Exp.Immunol. 1981;43:174-179. View abstract.
  155. Lynch, S. R. and Cook, J. D. Interaction of vitamin C and iron. Ann.N.Y Acad.Sci 1980;355:32-44. View abstract.
  156. Harlan, W. R., Hull, A. L., Schmouder, R. L., Landis, J. R., Thompson, F. E., and Larkin, F. A. Blood pressure and nutrition in adults. The National Health and Nutrition Examination Survey. Am.J Epidemiol. 1984;120:17-28. View abstract.
  157. Koh, E. T. Effect of vitamin C on blood parameters of hypertensive subjects. J Okla.State Med Assoc. 1984;77:177-182. View abstract.
  158. Zemla, B. The role of selected dietary elements in breast cancer risk among native and migrant populations in Poland. Nutr Cancer 1984;6:187-195. View abstract.
  159. Dobson, H. M., Muir, M. M., and Hume, R. The effect of ascorbic acid on the seasonal variations in serum cholesterol levels. Scott.Med J 1984;29:176-182. View abstract.
  160. Bancalari, A., Seguel, C., Neira, F., Ruiz, I., and Calvo, C. [Prophylactic value of vitamin C in acute respiratory tract infections in schoolchildren]. Rev Med Chil. 1984;112:871-876. View abstract.
  161. Goodwin, C. W., Dorethy, J., Lam, V., and Pruitt, B. A., Jr. Randomized trial of efficacy of crystalloid and colloid resuscitation on hemodynamic response and lung water following thermal injury. Ann.Surg. 1983;197:520-531. View abstract.
  162. Anderson, R., Hay, I., van Wyk, H. A., and Theron, A. Ascorbic acid in bronchial asthma. S.Afr.Med J 4-23-1983;63:649-652. View abstract.
  163. Yoshioka, M., Matsushita, T., and Chuman, Y. Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years. Int J Vitam.Nutr Res 1984;54:343-347. View abstract.
  164. Vollset, S. E. and Bjelke, E. Does consumption of fruit and vegetables protect against stroke? Lancet 9-24-1983;2:742. View abstract.
  165. Kothari, L. K. and Jain, K. Effect of vitamin C administration on blood cholesterol level in man. Acta Biol.Acad.Sci Hung. 1977;28:111-114. View abstract.
  166. Kimbarowski, J. A. and Mokrow, N. J. [Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza]. Dtsch.Gesundheitsw. 12-21-1967;22:2413-2418. View abstract.
  167. Mochalkin, N. I. [Ascorbic acid in the complex therapy of acute pneumonia]. Voen.Med Zh. 1970;9:17-21. View abstract.
  168. Fidanza, A., Floridi, S., Martinoli, L., Mastroiacovo, P., Servi, M., Di, Virgilio D., and Ravallese, F. [Therapeutic action of vitamin C on cholesterol metabolism]. Boll.Soc.Ital.Biol.Sper. 3-30-1979;55:553-558. View abstract.
  169. Ginter, E., Kajaba, I., and Nizner, O. The effect of ascorbic acid on cholesterolemia in healthy subjects with seasonal deficit of vitamin C. Nutr Metab 1970;2:76-86. View abstract.
  170. Anderson, T. W., Reid, D. B., and Beaton, G. H. Vitamin C and the common cold: a double-blind trial. Can.Med Assoc.J 9-23-1972;107:503-508. View abstract.
  171. Spero, L. M. and Anderson, T. W. Letter: Ascorbic acid and common colds. Br Med J 11-10-1973;4:354. View abstract.
  172. Anderson, T. W., Reid, D. B., and Beaton, G. H. Vitamin C and the common cold. Can.Med Assoc.J 1-20-1973;108:133. View abstract.
  173. Anderson, T. W., Suranyi, G., and Beaton, G. H. The effect on winter illness of large doses of vitamin C. Can.Med Assoc.J 7-6-1974;111:31-36. View abstract.
  174. Wilson, T. S., Datta, S. B., Murrell, J. S., and Andrews, C. T. Relation of vitamin C levels to mortality in a geriatric hospital: a study of the effect of vitamin C administration. Age Ageing 1973;2:163-171. View abstract.
  175. Wilson, C. W., Loh, H. S., and Foster, F. G. The beneficial effect of vitamin C on the common cold. Eur.J Clin.Pharmacol. 1973;6:26-32. View abstract.
  176. Wilson, C. W., Loh, H. S., and Foster, F. G. Common cold symptomatology and vitamin C. Eur.J Clin.Pharmacol. 1973;6:196-202. View abstract.
  177. Coulehan, J. L., Reisinger, K. S., Rogers, K. D., and Bradley, D. W. Vitamin C prophylaxis in a boarding school. N.Engl.J Med 1-3-1974;290:6-10. View abstract.
  178. Jelenko, C., III, Wheeler, M. L., Callaway, B. D., Divilio, L. T., Bucklen, K. R., and Holdredge, T. D. Shock and resuscitation. II: Volume repletion with minimal edema using the "HALFD"(Hypertonic Albuminated Fluid Demand) regimen. JACEP. 1978;7:326-333. View abstract.
  179. Liljefors, I. [Vitamin C and the common cold]. Lakartidningen 7-5-1972;69:3304-3305. View abstract.
  180. Schwartz, A. R., Togo, Y., Hornick, R. B., Tominaga, S., and Gleckman, R. A. Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J Infect.Dis. 1973;128:500-505. View abstract.
  181. Walker, G. H., Bynoe, M. L., and Tyrrell, D. A. Trial of ascorbic acid in prevention of colds. Br Med J 3-11-1967;1:603-606. View abstract.
  182. Taylor, T. V., Rimmer, S., Day, B., Butcher, J., and Dymock, I. W. Ascorbic acid supplementation in the treatment of pressure-sores. Lancet 9-7-1974;2:544-546. View abstract.
  183. Knox, E. G. Ischaemic-heart-disease mortality and dietary intake of calcium. Lancet 6-30-1973;1:1465-1467. View abstract.
  184. Charleston, S. S. and Clegg, K. M. Ascorbic acid and the common cold. Lancet 6-24-1972;1:1401-1402. View abstract.
  185. Spittle, C. R. Atherosclerosis and vitamin C. Lancet 6-17-1972;1:1335. View abstract.
  186. Erden, F., Gulenc, S., Torun, M., Kocer, Z., Simsek, B., and Nebioglu, S. Ascorbic acid effect on some lipid fractions in human beings. Acta Vitaminol.Enzymol. 1985;7(1-2):131-137. View abstract.
  187. Israel, L., Hajji, O., Grefft-Alami, A., Desmoulins, D., Succari, M., Cals, M. J., Miocque, M., Breau, J. L., and Morere, J. F. [Vitamin A augmentation of the effects of chemotherapy in metastatic breast cancers after menopause. Randomized trial in 100 patients]. Ann.Med Interne (Paris) 1985;136:551-554. View abstract.
  188. Tarp, U., Overvad, K., Thorling, E. B., Graudal, H., and Hansen, J. C. Selenium treatment in rheumatoid arthritis. Scand.J Rheumatol. 1985;14:364-368. View abstract.
  189. Ascorbic acid does not cure cancer. Nutr Rev 1985;43:146-147. View abstract.
  190. Joffres, M. R., Reed, D. M., and Yano, K. Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu heart study. Am.J Clin.Nutr 1987;45:469-475. View abstract.
  191. Mayet, F. H., Sewdarsen, M., and Reinach, S. G. Ascorbic acid and cholesterol levels in patients with diabetes mellitus and coronary artery disease. S.Afr.Med J 11-22-1986;70:661-664. View abstract.
  192. Malo, J. L., Cartier, A., Pineau, L., L'Archeveque, J., Ghezzo, H., and Martin, R. R. Lack of acute effects of ascorbic acid on spirometry and airway responsiveness to histamine in subjects with asthma. J Allergy Clin.Immunol. 1986;78:1153-1158. View abstract.
  193. Lapidus, L., Andersson, H., Bengtsson, C., and Bosaeus, I. Dietary habits in relation to incidence of cardiovascular disease and death in women: a 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. Am.J Clin.Nutr 1986;44:444-448. View abstract.
  194. Enstrom, J. E., Kanim, L. E., and Breslow, L. The relationship between vitamin C intake, general health practices, and mortality in Alameda County, California. Am.J Public Health 1986;76:1124-1130. View abstract.
  195. Ginter, E., Zdichynec, B., Holzerova, O., Ticha, E., Kobza, R., Koziakova, M., Cerna, O., Ozdin, L., Hruba, F., Novakova, V., Sasko, E., and Gaher, M. Hypocholesterolemic effect of ascorbic acid in maturity-onset diabetes mellitus. Int J Vitam.Nutr Res 1978;48:368-373. View abstract.
  196. Kordansky, D. W., Rosenthal, R. R., and Norman, P. S. The effect of vitamin C on antigen-induced bronchospasm. J Allergy Clin.Immunol. 1979;63:61-64. View abstract.
  197. Labadarios, D., Brink, P. A., Weich, H. F., Visser, L., Louw, M. E., Shephard, G. S., and van Stuijvenberg, M. E. Plasma vitamin A, E, C and B6 levels in myocardial infarction. S.Afr.Med J 5-2-1987;71:561-563. View abstract.
  198. Blankenhorn, G. [Clinical effectiveness of Spondyvit (vitamin E) in activated arthroses. A multicenter placebo-controlled double-blind study]. Z.Orthop.Ihre Grenzgeb. 1986;124:340-343. View abstract.
  199. Machtey, I. and Ouaknine, L. Tocopherol in Osteoarthritis: a controlled pilot study. J Am.Geriatr.Soc. 1978;26:328-330. View abstract.
  200. Gey, K. F., Stahelin, H. B., Puska, P., and Evans, A. Relationship of plasma level of vitamin C to mortality from ischemic heart disease. Ann.N.Y Acad.Sci 1987;498:110-123. View abstract.
  201. Levine, B. A., Petroff, P. A., Slade, C. L., and Pruitt, B. A., Jr. Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient. J Trauma 1978;18:188-193. View abstract.
  202. Tyrrell, D. A., Craig, J. W., Meada, T. W., and White, T. A trial of ascorbic acid in the treatment of the common cold. Br J Prev.Soc.Med 1977;31:189-191. View abstract.
  203. The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J Clin.Epidemiol. 1988;41:105-114. View abstract.
  204. Gillilan, R. E., Mondell, B., and Warbasse, J. R. Quantitative evaluation of vitamin E in the treatment of angina pectoris. Am.Heart J 1977;93:444-449. View abstract.
  205. Aro, A., Kyllastinen, M., Kostiainen, E., Gref, C. G., Elfving, S., and Uusitalo, U. No effect on serum lipids by moderate and high doses of vitamin C in elderly subjects with low plasma ascorbic acid levels. Ann.Nutr Metab 1988;32:133-137. View abstract.
  206. Miller, J. Z., Nance, W. E., Norton, J. A., Wolen, R. L., Griffith, R. S., and Rose, R. J. Therapeutic effect of vitamin C. A co-twin control study. JAMA 1-17-1977;237:248-251. View abstract.
  207. La, Vecchia C., Decarli, A., Fasoli, M., and Gentile, A. Nutrition and diet in the etiology of endometrial cancer. Cancer 3-15-1986;57:1248-1253. View abstract.
  208. Bishop, N., Schorah, C. J., and Wales, J. K. The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study. Diabet.Med 1985;2:121-124. View abstract.
  209. Toniolo, P., Riboli, E., Protta, F., Charrel, M., and Cappa, A. P. Calorie-providing nutrients and risk of breast cancer. J Natl.Cancer Inst. 2-15-1989;81:278-286. View abstract.
  210. La, Vecchia C., Decarli, A., Franceschi, S., Gentile, A., Negri, E., and Parazzini, F. Dietary factors and the risk of breast cancer. Nutr Cancer 1987;10:205-214. View abstract.
  211. Morabia, A., Sorenson, A., Kumanyika, S. K., Abbey, H., Cohen, B. H., and Chee, E. Vitamin A, cigarette smoking, and airway obstruction. Am.Rev Respir.Dis. 1989;140:1312-1316. View abstract.
  212. Barer, D., Leibowitz, R., Ebrahim, S., Pengally, D., and Neale, R. Vitamin C status and other nutritional indices in patients with stroke and other acute illnesses: a case-control study. J Clin.Epidemiol. 1989;42:625-631. View abstract.
  213. Cooper, J. A., Rohan, T. E., Cant, E. L., Horsfall, D. J., and Tilley, W. D. Risk factors for breast cancer by oestrogen receptor status: a population-based case-control study. Br J Cancer 1989;59:119-125. View abstract.
  214. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am.J Epidemiol. 1989;129:687-702. View abstract.
  215. Ali, S. M. and Chakraborty, S. K. Role of plasma ascorbate in diabetic microangiopathy. Bangladesh Med Res Counc.Bull. 1989;15:47-59. View abstract.
  216. Hatwal, A., Gujral, A. S., Bhatia, R. P., Agrawal, J. K., and Bajpai, H. S. Association of hypomagnesemia with diabetic retinopathy. Acta Ophthalmol.(Copenh) 1989;67:714-716. View abstract.
  217. Erasmus, R. T., Olukoga, A. O., Alanamu, R. A., Adewoye, H. O., and Bojuwoye, B. Plasma magnesium and retinopathy in black African diabetics. Trop.Geogr.Med 1989;41:234-237. View abstract.
  218. Mostafa S el-, Garner, D. D., Garrett, L., Whaley, R. F., el-Sekate, M., and Kiker, M. Beneficial effects of vitamin C on risk factors of cardiovascular diseases. J Egypt.Public Health Assoc. 1989;64(1-2):123-133. View abstract.
  219. Hemila, H. and Chalker, E. Vitamin C for preventing and treating the common cold. Cochrane.Database.Syst.Rev. 2013;1:CD000980. View abstract.
  220. Wang, Z. F. and Xie, Y. M. [Adverse event case reports for Xiyanping injection based on literature]. Zhongguo Zhong.Yao Za Zhi. 2012;37:2792-2795. View abstract.
  221. Hislop, T. G., Band, P. R., Deschamps, M., Ng, V., Coldman, A. J., Worth, A. J., and Labo, T. Diet and histologic types of benign breast disease defined by subsequent risk of breast cancer. Am.J Epidemiol. 1990;131:263-270. View abstract.
  222. Li, H., Zou, Y., and Ding, G. Dietary factors associated with dental erosion: a meta-analysis. PLoS.One. 2012;7:e42626. View abstract.
  223. Juraschek, S. P., Guallar, E., Appel, L. J., and Miller, E. R., III. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Am J Clin.Nutr 2012;95:1079-1088. View abstract.
  224. Harrison, F. E. A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease. J Alzheimers.Dis. 2012;29:711-726. View abstract.
  225. Simard, A., Vobecky, J., and Vobecky, J. S. Nutrition and lifestyle factors in fibrocystic disease and cancer of the breast. Cancer Detect.Prev. 1990;14:567-572. View abstract.
  226. Crombie, I. K., Smith, W. C., Tavendale, R., and Tunstall-Pedoe, H. Geographical clustering of risk factors and lifestyle for coronary heart disease in the Scottish Heart Health Study. Br Heart J 1990;64:199-203. View abstract.
  227. Bergman, J., Schjott, J., and Blix, H. S. Prevention of urinary tract infections in nursing homes: lack of evidence-based prescription? BMC.Geriatr 2011;11:69. View abstract.
  228. Coombes, J. S. and Fassett, R. G. Antioxidant therapy in hemodialysis patients: a systematic review. Kidney Int 2012;81:233-246. View abstract.
  229. Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106:1632-1637. View abstract.
  230. Einerson, B., Nathorn, C., Kitiyakara, C., Sirada, M., and Thamlikitkul, V. The efficacy of ascorbic acid in suboptimal responsive anemic hemodialysis patients receiving erythropoietin: a meta-analysis. J Med.Assoc.Thai. 2011;94 Suppl 1:S134-S146. View abstract.
  231. Rossi, A. C. and Mullin, P. M. Prevention of pre-eclampsia with low-dose aspirin or vitamins C and E in women at high or low risk: a systematic review with meta-analysis. Eur.J Obstet.Gynecol.Reprod.Biol. 2011;158:9-16. View abstract.
  232. Van, 't, V, Kolb, C. M., Verhoef, P., Kok, F. J., Schouten, E. G., Hermus, R. J., and Sturmans, F. Dietary fiber, beta-carotene and breast cancer: results from a case-control study. Int J Cancer 5-15-1990;45:825-828. View abstract.
  233. Conde-Agudelo, A., Romero, R., Kusanovic, J. P., and Hassan, S. S. Supplementation with vitamins C and E during pregnancy for the prevention of preeclampsia and other adverse maternal and perinatal outcomes: a systematic review and metaanalysis. Am J Obstet.Gynecol. 2011;204:503-512. View abstract.
  234. Rasoli, S., Kourliouros, A., Harling, L., and Athanasiou, T. Does prophylactic therapy with antioxidant vitamins have an effect on atrial fibrillation following cardiac surgery? Interact.Cardiovasc.Thorac.Surg. 2011;13:82-85. View abstract.
  235. Cuerda, C., Luengo, L. M., Valero, M. A., Vidal, A., Burgos, R., Calvo, F. L., and Martinez, C. [Antioxidants and diabetes mellitus: review of the evidence]. Nutr Hosp. 2011;26:68-78. View abstract.
  236. el-Kholy, M. S., Gas Allah, M. A., el-Shimi, S., el-Baz, F., el-Tayeb, H., and Abdel-Hamid, M. S. Zinc and copper status in children with bronchial asthma and atopic dermatitis. J Egypt.Public Health Assoc. 1990;65(5-6):657-668. View abstract.
  237. Riemersma, R. A., Oliver, M., Elton, R. A., Alfthan, G., Vartiainen, E., Salo, M., Rubba, P., Mancini, M., Georgi, H., Vuilleumier, J. P., and . Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium. Eur.J Clin.Nutr 1990;44:143-150. View abstract.
  238. Edgar, D. W., Fish, J. S., Gomez, M., and Wood, F. M. Local and systemic treatments for acute edema after burn injury: a systematic review of the literature. J Burn Care Res 2011;32:334-347. View abstract.
  239. Basaran, A., Basaran, M., and Topatan, B. Combined vitamin C and E supplementation for the prevention of preeclampsia: a systematic review and meta-analysis. Obstet Gynecol.Surv. 2010;65:653-667. View abstract.
  240. Papoulidis, P., Ananiadou, O., Chalvatzoulis, E., Ampatzidou, F., Koutsogiannidis, C., Karaiskos, T., Madesis, A., and Drossos, G. The role of ascorbic acid in the prevention of atrial fibrillation after elective on-pump myocardial revascularization surgery: a single-center experience--a pilot study. Interact.Cardiovasc.Thorac.Surg. 2011;12:121-124. View abstract.
  241. Scherak, O., Kolarz, G., Schodl, C., and Blankenhorn, G. [High dosage vitamin E therapy in patients with activated arthrosis]. Z.Rheumatol 1990;49:369-373. View abstract.
  242. Tian, J., Peehl, D. M., and Knox, S. J. Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry. Cancer Biother.Radiopharm. 2010;25:439-448. View abstract.
  243. Hauth, J. C., Clifton, R. G., Roberts, J. M., Spong, C. Y., Myatt, L., Leveno, K. J., Pearson, G. D., Varner, M. W., Thorp, J. M., Jr., Mercer, B. M., Peaceman, A. M., Ramin, S. M., Sciscione, A., Harper, M., Tolosa, J. E., Saade, G., Sorokin, Y., and Anderson, G. B. Vitamin C and E supplementation to prevent spontaneous preterm birth: a randomized controlled trial. Obstet Gynecol. 2010;116:653-658. View abstract.
  244. Shargorodsky, M., Debby, O., Matas, Z., and Zimlichman, R. Effect of long-term treatment with antioxidants (vitamin C, vitamin E, coenzyme Q10 and selenium) on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab (Lond) 2010;7:55. View abstract.
  245. McCance, D. R., Holmes, V. A., Maresh, M. J., Patterson, C. C., Walker, J. D., Pearson, D. W., and Young, I. S. Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet 7-24-2010;376:259-266. View abstract.
  246. Abdollahzad, H., Eghtesadi, S., Nourmohammadi, I., Khadem-Ansari, M., Nejad-Gashti, H., and Esmaillzadeh, A. Effect of vitamin C supplementation on oxidative stress and lipid profiles in hemodialysis patients. Int J Vitam.Nutr Res 2009;79(5-6):281-287. View abstract.
  247. Timpson, N. J., Forouhi, N. G., Brion, M. J., Harbord, R. M., Cook, D. G., Johnson, P., McConnachie, A., Morris, R. W., Rodriguez, S., Luan, J., Ebrahim, S., Padmanabhan, S., Watt, G., Bruckdorfer, K. R., Wareham, N. J., Whincup, P. H., Chanock, S., Sattar, N., Lawlor, D. A., and Davey, Smith G. Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am.J Clin.Nutr 2010;92:375-382. View abstract.
  248. Atherton, J. G., Kratzing, C. C., and Fisher, A. The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus. Arch.Virol. 1978;56:195-199. View abstract.
  249. Glazebrook, A. J. and Thomson, S. The administration of vitamin C in a large institution and its effect on general health and resistance to infection. J Hyg.(Lond) 1942;42:1-19. View abstract.
  250. Roberts, J. M., Myatt, L., Spong, C. Y., Thom, E. A., Hauth, J. C., Leveno, K. J., Pearson, G. D., Wapner, R. J., Varner, M. W., Thorp, J. M., Jr., Mercer, B. M., Peaceman, A. M., Ramin, S. M., Carpenter, M. W., Samuels, P., Sciscione, A., Harper, M., Smith, W. J., Saade, G., Sorokin, Y., and Anderson, G. B. Vitamins C and E to prevent complications of pregnancy-associated hypertension. N.Engl.J Med 4-8-2010;362:1282-1291. View abstract.
  251. Xu, H., Perez-Cuevas, R., Xiong, X., Reyes, H., Roy, C., Julien, P., Smith, G., von, Dadelszen P., Leduc, L., Audibert, F., Moutquin, J. M., Piedboeuf, B., Shatenstein, B., Parra-Cabrera, S., Choquette, P., Winsor, S., Wood, S., Benjamin, A., Walker, M., Helewa, M., Dube, J., Tawagi, G., Seaward, G., Ohlsson, A., Magee, L. A., Olatunbosun, F., Gratton, R., Shear, R., Demianczuk, N., Collet, J. P., Wei, S., and Fraser, W. D. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am.J Obstet Gynecol. 2010;202:239. View abstract.
  252. Miyake, Y., Sasaki, S., Tanaka, K., and Hirota, Y. Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy 6-1-2010;65:758-765. View abstract.
  253. Lee, C. T., Gayton, E. L., Beulens, J. W., Flanagan, D. W., and Adler, A. I. Micronutrients and diabetic retinopathy a systematic review. Ophthalmology 2010;117:71-78. View abstract.
  254. Gey, K. F., Puska, P., Jordan, P., and Moser, U. K. Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am.J Clin.Nutr 1991;53(1 Suppl):326S-334S. View abstract.
  255. Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28:417-434. View abstract.
  256. Miyake, Y., Sasaki, S., Tanaka, K., and Hirota, Y. Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants. Eur.Respir.J 2010;35:1228-1234. View abstract.
  257. Honest, H., Forbes, C. A., Duree, K. H., Norman, G., Duffy, S. B., Tsourapas, A., Roberts, T. E., Barton, P. M., Jowett, S. M., Hyde, C. J., and Khan, K. S. Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technol Assess. 2009;13:1-627. View abstract.
  258. Deved, V., Poyah, P., James, M. T., Tonelli, M., Manns, B. J., Walsh, M., and Hemmelgarn, B. R. Ascorbic acid for anemia management in hemodialysis patients: a systematic review and meta-analysis. Am.J Kidney Dis. 2009;54:1089-1097. View abstract.
  259. Delmi, M., Rapin, C. H., Bengoa, J. M., Delmas, P. D., Vasey, H., and Bonjour, J. P. Dietary supplementation in elderly patients with fractured neck of the femur. Lancet 4-28-1990;335:1013-1016. View abstract.
  260. McRae, M. P. Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials. J Chiropr.Med 2008;7:48-58. View abstract.
  261. McRae, M. P. Is vitamin C an effective antihypertensive supplement? A review and analysis of the literature. J Chiropr.Med 2006;5:60-64. View abstract.
  262. McRae, M. P. The efficacy of vitamin C supplementation on reducing total serum cholesterol in human subjects: a review and analysis of 51 experimental trials. J Chiropr.Med 2006;5:2-12. View abstract.
  263. Sezikli, M., Cetinkaya, Z. A., Sezikli, H., Guzelbulut, F., Tiftikci, A., Ince, A. T., Gokden, Y., Yasar, B., Atalay, S., and Kurdas, O. O. Oxidative stress in Helicobacter pylori infection: does supplementation with vitamins C and E increase the eradication rate? Helicobacter. 2009;14:280-285. View abstract.
  264. Erkkola, M., Kaila, M., Nwaru, B. I., Kronberg-Kippila, C., Ahonen, S., Nevalainen, J., Veijola, R., Pekkanen, J., Ilonen, J., Simell, O., Knip, M., and Virtanen, S. M. Maternal vitamin D intake during pregnancy is inversely associated with asthma and allergic rhinitis in 5-year-old children. Clin.Exp.Allergy 2009;39:875-882. View abstract.
  265. Graham, S., Hellmann, R., Marshall, J., Freudenheim, J., Vena, J., Swanson, M., Zielezny, M., Nemoto, T., Stubbe, N., and Raimondo, T. Nutritional epidemiology of postmenopausal breast cancer in western New York. Am.J Epidemiol. 9-15-1991;134:552-566. View abstract.
  266. Zojaji, H., Talaie, R., Mirsattari, D., Haghazali, M., Molaei, M., Mohsenian, N., Derakhshan, F., and Zali, M. R. The efficacy of Helicobacter pylori eradication regimen with and without vitamin C supplementation. Dig.Liver Dis. 2009;41:644-647. View abstract.
  267. Arroll, B. Common cold. Clin.Evid.(Online.) 2008;2008 View abstract.
  268. Manriquez, J. J., Majerson, Gringberg D., and Nicklas, Diaz C. Wrinkles. Clin.Evid.(Online.) 2008;2008 View abstract.
  269. Heimer, K. A., Hart, A. M., Martin, L. G., and Rubio-Wallace, S. Examining the evidence for the use of vitamin C in the prophylaxis and treatment of the common cold. J Am.Acad.Nurse Pract. 2009;21:295-300. View abstract.
  270. Villar, J., Purwar, M., Merialdi, M., Zavaleta, N., Thi Nhu, Ngoc N., Anthony, J., De, Greeff A., Poston, L., and Shennan, A. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries. BJOG. 2009;116:780-788. View abstract.
  271. Wang, C., Li, Y., Zhu, K., Dong, Y. M., and Sun, C. H. Effects of supplementation with multivitamin and mineral on blood pressure and C-reactive protein in obese Chinese women with increased cardiovascular disease risk. Asia Pac.J Clin.Nutr 2009;18:121-130. View abstract.
  272. Shaheen, S. O., Northstone, K., Newson, R. B., Emmett, P. M., Sherriff, A., and Henderson, A. J. Dietary patterns in pregnancy and respiratory and atopic outcomes in childhood. Thorax 2009;64:411-417. View abstract.
  273. Back, O., Blomquist, H. K., Hernell, O., and Stenberg, B. Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm.Venereol. 2009;89:28-32. View abstract.
  274. Kaur, B., Rowe, B. H., and Arnold, E. Vitamin C supplementation for asthma. Cochrane.Database.Syst.Rev 2009;:CD000993. View abstract.
  275. Ishihara, L. and Brayne, C. A systematic review of nutritional risk factors of Parkinson's disease. Nutr Res.Rev 2005;18:259-282. View abstract.
  276. Shahrbanoo, K. and Taziki, O. Effect of intravenous ascorbic acid in hemodialysis patients with anemia and hyperferritinemia. Saudi.J Kidney Dis.Transpl. 2008;19:933-936. View abstract.
  277. Spinnato, J. A., Freire, S., Pinto E Silva JL, Rudge, M. V., Martins-Costa, S., Koch, M. A., Goco, N., Santos, Cde B., Cecatti, J. G., Costa, R., Ramos, J. G., Moss, N., and Sibai, B. M. Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis. Am J Obstet.Gynecol. 2008;199:433-438. View abstract.
  278. McKeever, T. M., Lewis, S. A., Smit, H. A., Burney, P., Cassano, P. A., and Britton, J. A multivariate analysis of serum nutrient levels and lung function. Respir.Res 2008;9:67. View abstract.
  279. Farah, R. and Shurtz-Swirski, R. The combined effect of calcium channel blocker Lercanidipine and antioxidants on low-grade systemic inflammation parameters in essential hypertension patients. Minerva Cardioangiol. 2008;56:467-476. View abstract.
  280. Ramos, R. and Martinez-Castelao, A. Lipoperoxidation and hemodialysis. Metabolism 2008;57:1369-1374. View abstract.
  281. de, Batlle J., Garcia-Aymerich, J., Barraza-Villarreal, A., Anto, J. M., and Romieu, I. Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. Allergy 2008;63:1310-1316. View abstract.
  282. Washio, K., Inagaki, M., Tsuji, M., Morio, Y., Akiyama, S., Gotoh, H., Gotoh, T., Gotoh, Y., and Oguchi, K. Oral vitamin C supplementation in hemodialysis patients and its effect on the plasma level of oxidized ascorbic acid and Cu/Zn superoxide dismutase, an oxidative stress marker. Nephron Clin.Pract. 2008;109:c49-c54. View abstract.
  283. Haftek, M., Mac-Mary, S., Le Bitoux, M. A., Creidi, P., Seite, S., Rougier, A., and Humbert, P. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin. Exp.Dermatol. 2008;17:946-952. View abstract.
  284. Castro-Rodriguez, J. A., Garcia-Marcos, L., Alfonseda Rojas, J. D., Valverde-Molina, J., and Sanchez-Solis, M. Mediterranean diet as a protective factor for wheezing in preschool children. J Pediatr. 2008;152:823-8, 828. View abstract.
  285. Hemila, H. and Koivula, T. T. Vitamin C for preventing and treating tetanus. Cochrane.Database.Syst.Rev 2008;:CD006665. View abstract.
  286. Willers, S. M., Wijga, A. H., Brunekreef, B., Kerkhof, M., Gerritsen, J., Hoekstra, M. O., de Jongste, J. C., and Smit, H. A. Maternal food consumption during pregnancy and the longitudinal development of childhood asthma. Am.J Respir.Crit Care Med 7-15-2008;178:124-131. View abstract.
  287. Kelly, A. M., Dwamena, B., Cronin, P., Bernstein, S. J., and Carlos, R. C. Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Ann.Intern.Med 2-19-2008;148:284-294. View abstract.
  288. Hemila, H. and Kaprio, J. Vitamin E supplementation may transiently increase tuberculosis risk in males who smoke heavily and have high dietary vitamin C intake. Br J Nutr 2008;100:896-902. View abstract.
  289. Lopes de Jesus, C. C., Atallah, A. N., Valente, O., and Moca Trevisani, V. F. Vitamin C and superoxide dismutase (SOD) for diabetic retinopathy. Cochrane.Database.Syst.Rev 2008;:CD006695. View abstract.
  290. Garcia, E., Aristizabal, G., Vasquez, C., Rodriguez-Martinez, C. E., Sarmiento, O. L., and Satizabal, C. L. Prevalence of and factors associated with current asthma symptoms in school children aged 6-7 and 13-14 yr old in Bogota, Colombia. Pediatr.Allergy Immunol. 2008;19:307-314. View abstract.
  291. Chatzi, L., Torrent, M., Romieu, I., Garcia-Esteban, R., Ferrer, C., Vioque, J., Kogevinas, M., and Sunyer, J. Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood. Thorax 2008;63:507-513. View abstract.
  292. Mahajan, A. S., Babbar, R., Kansal, N., Agarwal, S. K., and Ray, P. C. Antihypertensive and antioxidant action of amlodipine and vitamin C in patients of essential hypertension. J Clin.Biochem.Nutr 2007;40:141-147. View abstract.
  293. Gomez-Cabrera, M. C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., Sastre, J., and Vina, J. Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance. Am.J Clin.Nutr 2008;87:142-149. View abstract.
  294. Beser, E. The effects of short-term vitamin C on plasma bun, uric acid, cholesterol and triglyceride levels. Acta Med Hung. 1991;48(1-2):73-78. View abstract.
  295. Spinnato, J. A., Freire, S., Pinto E Silva JL, Cunha Rudge, M. V., Martins-Costa, S., Koch, M. A., Goco, N., Santos, Cde B., Cecatti, J. G., Costa, R., Ramos, J. G., Moss, N., and Sibai, B. M. Antioxidant therapy to prevent preeclampsia: a randomized controlled trial. Obstet Gynecol. 2007;110:1311-1318. View abstract.
  296. de, Luis D. and Aller, R. [Systematic review of nutritional support in pressure ulcer]. An.Med Interna 2007;24:342-345. View abstract.
  297. Rodrigo, R., Prat, H., Passalacqua, W., Araya, J., and Bachler, J. P. Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension. Clin.Sci (Lond) 2008;114:625-634. View abstract.
  298. Walter, R. M., Jr., Uriu-Hare, J. Y., Olin, K. L., Oster, M. H., Anawalt, B. D., Critchfield, J. W., and Keen, C. L. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care 1991;14:1050-1056. View abstract.
  299. Fitzsimon, N., Fallon, U., O'Mahony, D., Loftus, B. G., Bury, G., Murphy, A. W., and Kelleher, C. C. Mothers' dietary patterns during pregnancy and risk of asthma symptoms in children at 3 years. Ir Med J 2007;100:suppl-32. View abstract.
  300. Eslami, M., Badkoubeh, R. S., Mousavi, M., Radmehr, H., Salehi, M., Tavakoli, N., and Avadi, M. R. Oral ascorbic acid in combination with beta-blockers is more effective than beta-blockers alone in the prevention of atrial fibrillation after coronary artery bypass grafting. Tex.Heart Inst.J 2007;34:268-274. View abstract.
  301. Tsai, H. J. and Tsai, A. C. The association of diet with respiratory symptoms and asthma in schoolchildren in Taipei, Taiwan. J Asthma 2007;44:599-603. View abstract.
  302. Laaksi, I., Ruohola, J. P., Tuohimaa, P., Auvinen, A., Haataja, R., Pihlajamaki, H., and Ylikomi, T. An association of serum vitamin D concentrations < 40 nmol/L with acute respiratory tract infection in young Finnish men. Am.J Clin.Nutr 2007;86:714-717. View abstract.
  303. Sharma, A., Dabla, S., Agrawal, R. P., Barjatya, H., Kochar, D. K., and Kothari, R. P. Serum magnesium: an early predictor of course and complications of diabetes mellitus. J Indian Med Assoc. 2007;105:16, 18, 20. View abstract.
  304. Biesalski, H. K. and McGregor, G. P. Antioxidant therapy in critical care--is the microcirculation the primary target? Crit Care Med 2007;35(9 Suppl):S577-S583. View abstract.
  305. Chatzi, L., Torrent, M., Romieu, I., Garcia-Esteban, R., Ferrer, C., Vioque, J., Kogevinas, M., and Sunyer, J. Diet, wheeze, and atopy in school children in Menorca, Spain. Pediatr.Allergy Immunol. 2007;18:480-485. View abstract.
  306. Marshall, I. WITHDRAWN: Zinc for the common cold. Cochrane.Database.Syst.Rev 2006;:CD001364. View abstract.
  307. Douglas, R. M., Hemila, H., Chalker, E., and Treacy, B. Vitamin C for preventing and treating the common cold. Cochrane.Database.Syst.Rev 2007;:CD000980. View abstract.
  308. Devereux, G., McNeill, G., Newman, G., Turner, S., Craig, L., Martindale, S., Helms, P., and Seaton, A. Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates. Clin.Exp.Allergy 2007;37:1000-1008. View abstract.
  309. Bader, N., Bosy-Westphal, A., Koch, A., Rimbach, G., Weimann, A., Poulsen, H. E., and Muller, M. J. Effect of hyperbaric oxygen and vitamin C and E supplementation on biomarkers of oxidative stress in healthy men. Br J Nutr 2007;98:826-833. View abstract.
  310. Chuang, C. H., Sheu, B. S., Kao, A. W., Cheng, H. C., Huang, A. H., Yang, H. B., and Wu, J. J. Adjuvant effect of vitamin C on omeprazole-amoxicillin-clarithromycin triple therapy for Helicobacter pylori eradication. Hepatogastroenterology 2007;54:320-324. View abstract.
  311. Chatzi, L., Apostolaki, G., Bibakis, I., Skypala, I., Bibaki-Liakou, V., Tzanakis, N., Kogevinas, M., and Cullinan, P. Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete. Thorax 2007;62:677-683. View abstract.
  312. Tecklenburg, S. L., Mickleborough, T. D., Fly, A. D., Bai, Y., and Stager, J. M. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir.Med 2007;101:1770-1778. View abstract.
  313. Willers, S. M., Devereux, G., Craig, L. C., McNeill, G., Wijga, A. H., Abou El-Magd, W., Turner, S. W., Helms, P. J., and Seaton, A. Maternal food consumption during pregnancy and asthma, respiratory and atopic symptoms in 5-year-old children. Thorax 2007;62:773-779. View abstract.
  314. Plantinga, Y., Ghiadoni, L., Magagna, A., Giannarelli, C., Franzoni, F., Taddei, S., and Salvetti, A. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens. 2007;20:392-397. View abstract.
  315. Devereux, G., Litonjua, A. A., Turner, S. W., Craig, L. C., McNeill, G., Martindale, S., Helms, P. J., Seaton, A., and Weiss, S. T. Maternal vitamin D intake during pregnancy and early childhood wheezing. Am.J Clin.Nutr 2007;85:853-859. View abstract.
  316. Camargo, C. A., Jr., Rifas-Shiman, S. L., Litonjua, A. A., Rich-Edwards, J. W., Weiss, S. T., Gold, D. R., Kleinman, K., and Gillman, M. W. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am.J Clin.Nutr 2007;85:788-795. View abstract.
  317. Gale, C. R., Robinson, S. M., Harvey, N. C., Javaid, M. K., Jiang, B., Martyn, C. N., Godfrey, K. M., and Cooper, C. Maternal vitamin D status during pregnancy and child outcomes. Eur.J Clin.Nutr 2008;62:68-77. View abstract.
  318. Polyzos, N. P., Mauri, D., Tsappi, M., Tzioras, S., Kamposioras, K., Cortinovis, I., and Casazza, G. Combined vitamin C and E supplementation during pregnancy for preeclampsia prevention: a systematic review. Obstet Gynecol.Surv. 2007;62:202-206. View abstract.
  319. Okoko, B. J., Burney, P. G., Newson, R. B., Potts, J. F., and Shaheen, S. O. Childhood asthma and fruit consumption. Eur.Respir.J 2007;29:1161-1168. View abstract.
  320. Inui, S. and Itami, S. Perifollicular pigmentation is the first target for topical vitamin C derivative ascorbyl 2-phosphate 6-palmitate (APPS): randomized, single-blinded, placebo-controlled study. J Dermatol. 2007;34:221-223. View abstract.
  321. Kocabas, C. N., Adalioglu, G., Coskun, T., Tuncer, A., and Sekerel, B. E. The relationship between serum selenium levels and frequent wheeze in children. Turk.J Pediatr. 2006;48:308-312. View abstract.
  322. Hemila, H. and Louhiala, P. Vitamin C for preventing and treating pneumonia. Cochrane.Database.Syst.Rev 2007;:CD005532. View abstract.
  323. Taverner, D. and Latte, J. Nasal decongestants for the common cold. Cochrane.Database.Syst.Rev 2007;:CD001953. View abstract.
  324. Xu, W. H., Dai, Q., Xiang, Y. B., Zhao, G. M., Ruan, Z. X., Cheng, J. R., Zheng, W., and Shu, X. O. Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China. Int J Cancer 4-15-2007;120:1776-1781. View abstract.
  325. Johnson, A. R., Munoz, A., Gottlieb, J. L., and Jarrard, D. F. High dose zinc increases hospital admissions due to genitourinary complications. J Urol. 2007;177:639-643. View abstract.
  326. Pesonen, M., Kallio, M. J., Siimes, M. A., and Ranki, A. Retinol concentrations after birth are inversely associated with atopic manifestations in children and young adults. Clin.Exp.Allergy 2007;37:54-61. View abstract.
  327. Tamay, Z., Akcay, A., Ones, U., Guler, N., Kilic, G., and Zencir, M. Prevalence and risk factors for allergic rhinitis in primary school children. Int J Pediatr.Otorhinolaryngol. 2007;71:463-471. View abstract.
  328. Moriarty-Craige, S. E., Ha, K. N., Sternberg, P., Jr., Lynn, M., Bressler, S., Gensler, G., and Jones, D. P. Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration. Am.J Ophthalmol. 2007;143:206-211. View abstract.
  329. Moreira, A., Kekkonen, R. A., Delgado, L., Fonseca, J., Korpela, R., and Haahtela, T. Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis. Eur.J Clin.Nutr 2007;61:443-460. View abstract.
  330. Pastorino, A. C., Rimazza, R. D., Leone, C., Castro, A. P., Sole, D., and Jacob, C. M. Risk factors for asthma in adolescents in a large urban region of Brazil. J Asthma 2006;43:695-700. View abstract.
  331. Eiselt, J., Racek, J., Opatrny, K., Jr., Trefil, L., and Stehlik, P. The effect of intravenous iron on oxidative stress in hemodialysis patients at various levels of vitamin C. Blood Purif. 2006;24(5-6):531-537. View abstract.
  332. Litonjua, A. A., Rifas-Shiman, S. L., Ly, N. P., Tantisira, K. G., Rich-Edwards, J. W., Camargo, C. A., Jr., Weiss, S. T., Gillman, M. W., and Gold, D. R. Maternal antioxidant intake in pregnancy and wheezing illnesses in children at 2 y of age. Am.J Clin.Nutr 2006;84:903-911. View abstract.
  333. Nightingale, A. K., Crilley, J. G., Pegge, N. C., Boehm, E. A., Mumford, C., Taylor, D. J., Styles, P., Clarke, K., and Frenneaux, M. P. Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure. Eur.J Heart Fail. 2007;9:287-291. View abstract.
  334. Yoder, K. E., Shaffer, M. L., La Tournous, S. J., and Paul, I. M. Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection. Clin.Pediatr.(Phila) 2006;45:633-640. View abstract.
  335. Arroll, B. and Kenealy, T. Are antibiotics effective for acute purulent rhinitis? Systematic review and meta-analysis of placebo controlled randomised trials. BMJ 8-5-2006;333:279. View abstract.
  336. Singh, M. Heated, humidified air for the common cold. Cochrane.Database.Syst.Rev 2006;3:CD001728. View abstract.
  337. Spargias, K., Adreanides, E., Giamouzis, G., Karagiannis, S., Gouziouta, A., Manginas, A., Voudris, V., Pavlides, G., and Cokkinos, D. V. Iloprost for prevention of contrast-mediated nephropathy in high-risk patients undergoing a coronary procedure. Results of a randomized pilot study. Eur.J Clin.Pharmacol. 2006;62:589-595. View abstract.
  338. Mizuno, Y., Furusho, T., Yoshida, A., Nakamura, H., Matsuura, T., and Eto, Y. Serum vitamin A concentrations in asthmatic children in Japan. Pediatr.Int 2006;48:261-264. View abstract.
  339. Riemersma, R. A., Wood, D. A., Macintyre, C. C., Elton, R. A., Gey, K. F., and Oliver, M. F. Risk of angina pectoris and plasma concentrations of vitamins A, C, and E and carotene. Lancet 1-5-1991;337:1-5. View abstract.
  340. Tahan, F. and Karakukcu, C. Zinc status in infantile wheezing. Pediatr.Pulmonol. 2006;41:630-634. View abstract.
  341. Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23:171-178. View abstract.
  342. Rumbold, A. R., Crowther, C. A., Haslam, R. R., Dekker, G. A., and Robinson, J. S. Vitamins C and E and the risks of preeclampsia and perinatal complications. N.Engl.J Med 4-27-2006;354:1796-1806. View abstract.
  343. Poston, L., Briley, A. L., Seed, P. T., Kelly, F. J., and Shennan, A. H. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet 4-8-2006;367:1145-1154. View abstract.
  344. Peterson, V. E., Crapo, P. A., Weininger, J., Ginsberg, H., and Olefsky, J. Quantification of plasma cholesterol and triglyceride levels in hypercholesterolemic subjects receiving ascorbic acid supplements. Am.J Clin.Nutr 1975;28:584-587. View abstract.
  345. Attallah, N., Osman-Malik, Y., Frinak, S., and Besarab, A. Effect of intravenous ascorbic acid in hemodialysis patients with EPO-hyporesponsive anemia and hyperferritinemia. Am.J Kidney Dis. 2006;47:644-654. View abstract.
  346. Murray, C. S., Simpson, B., Kerry, G., Woodcock, A., and Custovic, A. Dietary intake in sensitized children with recurrent wheeze and healthy controls: a nested case-control study. Allergy 2006;61:438-442. View abstract.
  347. Ochs-Balcom, H. M., Grant, B. J., Muti, P., Sempos, C. T., Freudenheim, J. L., Browne, R. W., McCann, S. E., Trevisan, M., Cassano, P. A., Iacoviello, L., and Schunemann, H. J. Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD. Eur.J Clin.Nutr 2006;60:991-999. View abstract.
  348. Yang, C. C., Hsu, S. P., Wu, M. S., Hsu, S. M., and Chien, C. T. Effects of vitamin C infusion and vitamin E-coated membrane on hemodialysis-induced oxidative stress. Kidney Int 2006;69:706-714. View abstract.
  349. Karlowski, T. R., Chalmers, T. C., Frenkel, L. D., Kapikian, A. Z., Lewis, T. L., and Lynch, J. M. Ascorbic acid for the common cold. A prophylactic and therapeutic trial. JAMA 3-10-1975;231:1038-1042. View abstract.
  350. Fogarty, A., Lewis, S. A., Scrivener, S. L., Antoniak, M., Pacey, S., Pringle, M., and Britton, J. Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial. Respir.Med 2006;100:174-179. View abstract.
  351. Carson, M., Cox, H., Corbett, M., and Pollitt, N. Vitamin C and the common cold. J Soc.Occup.Med 1975;25:99-102. View abstract.
  352. Tabak, C., Wijga, A. H., de, Meer G., Janssen, N. A., Brunekreef, B., and Smit, H. A. Diet and asthma in Dutch school children (ISAAC-2). Thorax 2006;61:1048-1053. View abstract.
  353. Boothby, L. A. and Doering, P. L. Vitamin C and vitamin E for Alzheimer's disease. Ann.Pharmacother. 2005;39:2073-2080. View abstract.
  354. Czernichow, S., Bertrais, S., Blacher, J., Galan, P., Briancon, S., Favier, A., Safar, M., and Hercberg, S. Effect of supplementation with antioxidants upon long-term risk of hypertension in the SU.VI.MAX study: association with plasma antioxidant levels. J Hypertens. 2005;23:2013-2018. View abstract.
  355. Chan, D., Irish, A., Croft, K. D., and Dogra, G. Effect of ascorbic acid supplementation on plasma isoprostanes in haemodialysis patients. Nephrol.Dial.Transplant. 2006;21:234-235. View abstract.
  356. Lee, D. H. and Jacobs, D. R., Jr. Interaction among heme iron, zinc, and supplemental vitamin C intake on the risk of lung cancer: Iowa Women's Health Study. Nutr Cancer 2005;52:130-137. View abstract.
  357. Farvid, M. S., Jalali, M., Siassi, F., and Hosseini, M. Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in type 2 diabetes. Diabetes Care 2005;28:2458-2464. View abstract.
  358. Nouraie, M., Pietinen, P., Kamangar, F., Dawsey, S. M., Abnet, C. C., Albanes, D., Virtamo, J., and Taylor, P. R. Fruits, vegetables, and antioxidants and risk of gastric cancer among male smokers. Cancer Epidemiol.Biomarkers Prev. 2005;14:2087-2092. View abstract.
  359. Gupta, M. M. and Chari, S. Lipid peroxidation and antioxidant status in patients with diabetic retinopathy. Indian J Physiol Pharmacol. 2005;49:187-192. View abstract.
  360. Chen, H., Karne, R. J., Hall, G., Campia, U., Panza, J. A., Cannon, R. O., III, Wang, Y., Katz, A., Levine, M., and Quon, M. J. High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance. Am.J Physiol Heart Circ.Physiol 2006;290:H137-H145. View abstract.
  361. Sasazuki, S., Sasaki, S., Tsubono, Y., Okubo, S., Hayashi, M., and Tsugane, S. Effect of vitamin C on common cold: randomized controlled trial. Eur.J Clin.Nutr 2006;60:9-17. View abstract.
  362. Chan, D., Irish, A., and Dogra, G. Efficacy and safety of oral versus intravenous ascorbic acid for anaemia in haemodialysis patients. Nephrology.(Carlton.) 2005;10:336-340. View abstract.
  363. Arroll, B. and Kenealy, T. Antibiotics for the common cold and acute purulent rhinitis. Cochrane.Database.Syst.Rev 2005;:CD000247. View abstract.
  364. Pearson, P., Britton, J., McKeever, T., Lewis, S. A., Weiss, S., Pavord, I., and Fogarty, A. Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population. Eur.J Clin.Nutr 2005;59:1043-1048. View abstract.
  365. Hutchins, A. M., McIver, I. E., and Johnston, C. S. Soy isoflavone and ascorbic acid supplementation alone or in combination minimally affect plasma lipid peroxides in healthy postmenopausal women. J.Am.Diet.Assoc. 2005;105:1134-1137. View abstract.
  366. Nja, F., Nystad, W., Lodrup Carlsen, K. C., Hetlevik, O., and Carlsen, K. H. Effects of early intake of fruit or vegetables in relation to later asthma and allergic sensitization in school-age children. Acta Paediatr. 2005;94:147-154. View abstract.
  367. Fumeron, C., Nguyen-Khoa, T., Saltiel, C., Kebede, M., Buisson, C., Drueke, T. B., Lacour, B., and Massy, Z. A. Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients. Nephrol.Dial.Transplant. 2005;20:1874-1879. View abstract.
  368. Hozyasz, K. K., Chelchowska, M., Laskowska-Klita, T., Ruszkowska, L., and Milanowski, A. [Low concentration of alpha-tocopherol in erythrocytes of atopic dermatitis patients]. Med Wieku.Rozwoj. 2004;8(4 Pt 1):963-969. View abstract.
  369. Etminan, M., Gill, S. S., and Samii, A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurol. 2005;4:362-365. View abstract.
  370. Rumbold, A. and Crowther, C. A. Vitamin C supplementation in pregnancy. Cochrane.Database.Syst.Rev 2005;:CD004072. View abstract.
  371. Rumbold, A. and Crowther, C. A. Vitamin E supplementation in pregnancy. Cochrane.Database.Syst.Rev 2005;:CD004069. View abstract.
  372. Maxwell, C. J., Hicks, M. S., Hogan, D. B., Basran, J., and Ebly, E. M. Supplemental use of antioxidant vitamins and subsequent risk of cognitive decline and dementia. Dement.Geriatr.Cogn Disord. 2005;20:45-51. View abstract.
  373. Casanueva, E., Ripoll, C., Tolentino, M., Morales, R. M., Pfeffer, F., Vilchis, P., and Vadillo-Ortega, F. Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. Am.J Clin.Nutr 2005;81:859-863. View abstract.
  374. Falsaperla, M., Morgia, G., Tartarone, A., Ardito, R., and Romano, G. Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate. Eur.Urol. 2005;47:449-454. View abstract.
  375. Canavese, C., Petrarulo, M., Massarenti, P., Berutti, S., Fenoglio, R., Pauletto, D., Lanfranco, G., Bergamo, D., Sandri, L., and Marangella, M. Long-term, low-dose, intravenous vitamin C leads to plasma calcium oxalate supersaturation in hemodialysis patients. Am.J Kidney Dis. 2005;45:540-549. View abstract.
  376. Darlow, B. A., Buss, H., McGill, F., Fletcher, L., Graham, P., and Winterbourn, C. C. Vitamin C supplementation in very preterm infants: a randomised controlled trial. Arch.Dis.Child Fetal Neonatal Ed 2005;90:F117-F122. View abstract.
  377. Lewis, S. A., Antoniak, M., Venn, A. J., Davies, L., Goodwin, A., Salfield, N., Britton, J., and Fogarty, A. W. Secondhand smoke, dietary fruit intake, road traffic exposures, and the prevalence of asthma: a cross-sectional study in young children. Am.J Epidemiol. 3-1-2005;161:406-411. View abstract.
  378. Hypponen, E., Sovio, U., Wjst, M., Patel, S., Pekkanen, J., Hartikainen, A. L., and Jarvelinb, M. R. Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann.N.Y Acad.Sci 2004;1037:84-95. View abstract.
  379. Beazley, D., Ahokas, R., Livingston, J., Griggs, M., and Sibai, B. M. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am.J Obstet Gynecol. 2005;192:520-521. View abstract.
  380. Lingstrom, P., Fure, S., Dinitzen, B., Fritzne, C., Klefbom, C., and Birkhed, D. The release of vitamin C from chewing gum and its effects on supragingival calculus formation. Eur.J Oral Sci 2005;113:20-27. View abstract.
  381. Tam, L. S., Li, E. K., Leung, V. Y., Griffith, J. F., Benzie, I. F., Lim, P. L., Whitney, B., Lee, V. W., Lee, K. K., Thomas, G. N., and Tomlinson, B. Effects of vitamins C and E on oxidative stress markers and endothelial function in patients with systemic lupus erythematosus: a double blind, placebo controlled pilot study. J Rheumatol. 2005;32:275-282. View abstract.
  382. Lu, Q., Bjorkhem, I., Wretlind, B., Diczfalusy, U., Henriksson, P., and Freyschuss, A. Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study. Clin.Sci (Lond) 2005;108:507-513. View abstract.
  383. Adams, J. B. and Holloway, C. Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. J Altern Complement Med 2004;10:1033-1039. View abstract.
  384. Pathak, A. K., Bhutani, M., Guleria, R., Bal, S., Mohan, A., Mohanti, B. K., Sharma, A., Pathak, R., Bhardwaj, N. K., Prasad, K. N., and Kochupillai, V. Chemotherapy alone vs. chemotherapy plus high dose multiple antioxidants in patients with advanced non small cell lung cancer. J Am.Coll.Nutr 2005;24:16-21. View abstract.
  385. Mooney, L. A., Madsen, A. M., Tang, D., Orjuela, M. A., Tsai, W. Y., Garduno, E. R., and Perera, F. P. Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers. Cancer Epidemiol.Biomarkers Prev. 2005;14:237-242. View abstract.
  386. Awasthi, S., Kalra, E., Roy, S., and Awasthi, S. Prevalence and risk factors of asthma and wheeze in school-going children in Lucknow, North India. Indian Pediatr. 2004;41:1205-1210. View abstract.
  387. Magen, E., Viskoper, R., Mishal, J., Priluk, R., Berezovsky, A., Laszt, A., London, D., and Yosefy, C. Resistant arterial hypertension and hyperlipidemia: atorvastatin, not vitamin C, for blood pressure control. Isr.Med Assoc.J 2004;6:742-746. View abstract.
  388. Hemila, H. Vitamin C supplementation and respiratory infections: a systematic review. Mil.Med 2004;169:920-925. View abstract.
  389. Genkinger, J. M., Platz, E. A., Hoffman, S. C., Comstock, G. W., and Helzlsouer, K. J. Fruit, vegetable, and antioxidant intake and all-cause, cancer, and cardiovascular disease mortality in a community-dwelling population in Washington County, Maryland. Am.J Epidemiol. 12-15-2004;160:1223-1233. View abstract.
  390. Schutte, A. E., Huisman, H. W., Oosthuizen, W., van Rooyen, J. M., and Jerling, J. C. Cardiovascular effects of oral Supplementation of vitamin C, E and folic acid in young healthy males. Int J Vitam.Nutr Res 2004;74:285-293. View abstract.
  391. McKeever, T. M., Lewis, S. A., Smit, H., Burney, P., Britton, J., and Cassano, P. A. Serum nutrient markers and skin prick testing using data from the Third National Health and Nutrition Examination Survey. J Allergy Clin.Immunol. 2004;114:1398-1402. View abstract.
  392. Martindale, S., McNeill, G., Devereux, G., Campbell, D., Russell, G., and Seaton, A. Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. Am.J Respir.Crit Care Med 1-15-2005;171:121-128. View abstract.
  393. Manders, M., de Groot, L. C., van Staveren, W. A., Wouters-Wesseling, W., Mulders, A. J., Schols, J. M., and Hoefnagels, W. H. Effectiveness of nutritional supplements on cognitive functioning in elderly persons: a systematic review. J Gerontol.A Biol.Sci Med Sci 2004;59:1041-1049. View abstract.
  394. Hulisz, D. Efficacy of zinc against common cold viruses: an overview. J Am.Pharm Assoc. 2004;44:594-603. View abstract.
  395. Schroeder, K. and Fahey, T. Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane.Database.Syst.Rev 2004;:CD001831. View abstract.
  396. Douglas, R. M., Hemila, H., D'Souza, R., Chalker, E. B., and Treacy, B. Vitamin C for preventing and treating the common cold. Cochrane.Database.Syst.Rev 2004;:CD000980. View abstract.
  397. Almendingen, K., Hofstad, B., and Vatn, M. H. Dietary habits and growth and recurrence of colorectal adenomas: results from a three-year endoscopic follow-up study. Nutr Cancer 2004;49:131-138. View abstract.
  398. Petersen, E. E. and Magnani, P. Efficacy and safety of vitamin C vaginal tablets in the treatment of non-specific vaginitis. A randomised, double blind, placebo-controlled study. Eur.J Obstet Gynecol.Reprod.Biol. 11-10-2004;117:70-75. View abstract.
  399. COWAN, D. W. and DIEHL, H. S. Antihistaminic agents and ascorbic acid in the early treatment of the common cold. J Am.Med Assoc. 6-3-1950;143:421-424. View abstract.
  400. Shaheen, S. O., Newson, R. B., Henderson, A. J., Emmett, P. M., Sherriff, A., and Cooke, M. Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Eur.Respir.J 2004;24:292-297. View abstract.
  401. Wong, G. W., Ko, F. W., Hui, D. S., Fok, T. F., Carr, D., von, Mutius E., Zhong, N. S., Chen, Y. Z., and Lai, C. K. Factors associated with difference in prevalence of asthma in children from three cities in China: multicentre epidemiological survey. BMJ 8-28-2004;329:486. View abstract.
  402. Teramoto, K., Daimon, M., Hasegawa, R., Toyoda, T., Sekine, T., Kawata, T., Yoshida, K., and Komuro, I. Acute effect of oral vitamin C on coronary circulation in young healthy smokers. Am.Heart J 2004;148:300-305. View abstract.
  403. Taverner, D., Latte, J., and Draper, M. Nasal decongestants for the common cold. Cochrane.Database.Syst.Rev 2004;:CD001953. View abstract.
  404. Tarng, D. C., Liu, T. Y., and Huang, T. P. Protective effect of vitamin C on 8-hydroxy-2'-deoxyguanosine level in peripheral blood lymphocytes of chronic hemodialysis patients. Kidney Int 2004;66:820-831. View abstract.
  405. Milner, J. D., Stein, D. M., McCarter, R., and Moon, R. Y. Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 2004;114:27-32. View abstract.
  406. Romieu, I., Mannino, D. M., Redd, S. C., and McGeehin, M. A. Dietary intake, physical activity, body mass index, and childhood asthma in the Third National Health And Nutrition Survey (NHANES III). Pediatr.Pulmonol. 2004;38:31-42. View abstract.
  407. Clemons, T. E., Kurinij, N., and Sperduto, R. D. Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13. Arch.Ophthalmol. 2004;122:716-726. View abstract.
  408. Laurin, D., Masaki, K. H., Foley, D. J., White, L. R., and Launer, L. J. Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am.J.Epidemiol. 5-15-2004;159:959-967. View abstract.
  409. Millen, A. E., Klein, R., Folsom, A. R., Stevens, J., Palta, M., and Mares, J. A. Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study. Am.J Clin.Nutr 2004;79:865-873. View abstract.
  410. Singh, M. Heated, humidified air for the common cold. Cochrane.Database.Syst.Rev 2004;:CD001728. View abstract.
  411. SEVITT, S., BULL, J. P., CRUICKSHANK, C. N., JACKSON, D. M., and LOWBURY, E. J. Failure of an antihistamine drug to influence the course of experimental human burns. Br Med J 7-12-1952;2:57-62. View abstract.
  412. NIEMI, T. [Acute respiratory infections and vitamin C]. Duodecim 1951;67:360-368. View abstract.
  413. Harik-Khan, R. I., Muller, D. C., and Wise, R. A. Serum vitamin levels and the risk of asthma in children. Am.J Epidemiol. 2-15-2004;159:351-357. View abstract.
  414. Higginbotham, S., Zhang, Z. F., Lee, I. M., Cook, N. R., Giovannucci, E., Buring, J. E., and Liu, S. Dietary glycemic load and risk of colorectal cancer in the Women's Health Study. J Natl.Cancer Inst. 2-4-2004;96:229-233. View abstract.
  415. Jacques, P. F. A cross-sectional study of vitamin C intake and blood pressure in the elderly. Int J Vitam.Nutr Res 1992;62:252-255. View abstract.
  416. Deira, J., Diego, J., Martinez, R., Oyarbide, A., Gonzalez, A., Diaz, H., and Grande, J. Comparative study of intravenous ascorbic acid versus low-dose desferroxamine in patients on hemodialysis with hyperferritinemia. J Nephrol. 2003;16:703-709. View abstract.
  417. Pressman, E. K., Cavanaugh, J. L., Mingione, M., Norkus, E. P., and Woods, J. R. Effects of maternal antioxidant supplementation on maternal and fetal antioxidant levels: a randomized, double-blind study. Am J Obstet.Gynecol. 2003;189:1720-1725. View abstract.
  418. Robson, P. J., Bouic, P. J., and Myburgh, K. H. Antioxidant supplementation enhances neutrophil oxidative burst in trained runners following prolonged exercise. Int.J.Sport Nutr.Exerc.Metab 2003;13:369-381. View abstract.
  419. Hofstad, B., Vatn, M., Hoff, G., Larsen, S., and Osnes, M. Growth of colorectal polyps: design of a prospective, randomized, placebo-controlled intervention study in patients with colorectal polyps. Eur.J Cancer Prev. 1992;1:415-422. View abstract.
  420. Kato, I., Miura, S., Kasumi, F., Iwase, T., Tashiro, H., Fujita, Y., Koyama, H., Ikeda, T., Fujiwara, K., Saotome, K., and . A case-control study of breast cancer among Japanese women: with special reference to family history and reproductive and dietary factors. Breast Cancer Res Treat. 1992;24:51-59. View abstract.
  421. Rubin, R. N., Navon, L., and Cassano, P. A. Relationship of serum antioxidants to asthma prevalence in youth. Am.J Respir.Crit Care Med 2-1-2004;169:393-398. View abstract.
  422. Farchi, S., Forastiere, F., Agabiti, N., Corbo, G., Pistelli, R., Fortes, C., Dell'Orco, V., and Perucci, C. A. Dietary factors associated with wheezing and allergic rhinitis in children. Eur.Respir.J 2003;22:772-780. View abstract.
  423. Langer, G., Schloemer, G., Knerr, A., Kuss, O., and Behrens, J. Nutritional interventions for preventing and treating pressure ulcers. Cochrane.Database.Syst.Rev 2003;:CD003216. View abstract.
  424. Lassus, A., Eskelinen, A., and Santalahti, J. The effect of Vivida cream as compared with placebo cream in the treatment of sun-damaged or age-damaged facial skin. J Int Med Res 1992;20:381-391. View abstract.
  425. Feldman, E. B., Gold, S., Greene, J., Moran, J., Xu, G., Shultz, G. G., Hames, C. G., and Feldman, D. S. Ascorbic acid supplements and blood pressure. A four-week pilot study. Ann.N.Y Acad.Sci 9-30-1992;669:342-344. View abstract.
  426. Sinclair, A. J., Girling, A. J., Gray, L., Lunec, J., and Barnett, A. H. An investigation of the relationship between free radical activity and vitamin C metabolism in elderly diabetic subjects with retinopathy. Gerontology 1992;38:268-274. View abstract.
  427. Moor de, Burgos A., Wartanowicz, M., and Ziemlanski, S. Blood vitamin and lipid levels in overweight and obese women. Eur.J Clin.Nutr 1992;46:803-808. View abstract.
  428. Eskelinen, A. and Santalahti, J. Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen. J Int Med Res 1992;20:227-233. View abstract.
  429. BRISCOE, C. C. The role of vitamin C-hesperidin in the prevention of abortion. Obstet Gynecol. 1959;14:288-290. View abstract.
  430. BESSEL-LORCK, C. [Common cold prophylaxis in young people at a ski-camp]. Med Nov. 10-31-1959;44:2126-2127. View abstract.
  431. RITZEL, G. [Critical evaluation of vitamin C as a prophylactic and therapeutic agent in colds]. Helv.Med Acta 1961;28:63-68. View abstract.
  432. Wu, H. P., Tai, T. Y., Chuang, L. M., Lin, B. J., Wang, J. D., and Teng, C. M. Effect of tocopherol on platelet aggregation in non-insulin-dependent diabetes mellitus: ex vivo and in vitro studies. J Formos.Med Assoc 1992;91:270-275. View abstract.
  433. FRANZ, W. L., HEYL, H. L., and SANDS, G. W. Blood ascorbic acid level in bioflavonoid and ascorbic acid therapy of common cold. J Am.Med Assoc. 11-24-1956;162:1224-1226. View abstract.
  434. Cerna, O., Ramacsay, L., and Ginter, E. Plasma lipids, lipoproteins and atherogenic index in men and women administered vitamin C. Cor Vasa 1992;34:246-254. View abstract.
  435. Gilliland, F. D., Berhane, K. T., Li, Y. F., Gauderman, W. J., McConnell, R., and Peters, J. Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. Am.J Epidemiol. 9-15-2003;158:576-584. View abstract.
  436. Millen, A. E., Gruber, M., Klein, R., Klein, B. E., Palta, M., and Mares, J. A. Relations of serum ascorbic acid and alpha-tocopherol to diabetic retinopathy in the Third National Health and Nutrition Examination Survey. Am.J Epidemiol. 8-1-2003;158:225-233. View abstract.
  437. Jensen, N. H. [Reduced pain from osteoarthritis in hip joint or knee joint during treatment with calcium ascorbate. A randomized, placebo-controlled cross-over trial in general practice]. Ugeskr.Laeger 6-16-2003;165:2563-2566. View abstract.
  438. Shidfar, F., Keshavarz, A., Jallali, M., Miri, R., and Eshraghian, M. Comparison of the effects of simultaneous administration of vitamin C and omega-3 fatty acids on lipoproteins, apo A-I, apo B, and malondialdehyde in hyperlipidemic patients. Int J Vitam.Nutr Res 2003;73:163-170. View abstract.
  439. Rezaian, G. R., Taheri, M., Mozaffari, B. E., Mosleh, A. A., and Ghalambor, M. A. The salutary effects of antioxidant vitamins on the plasma lipids of healthy middle aged-to-elderly individuals: a randomized, double-blind, placebo-controlled study. J Med Liban. 2002;50(1-2):10-13. View abstract.
  440. Chen, W. T., Lin, Y. F., Yu, F. C., Kao, W. Y., Huang, W. H., and Yan, H. C. Effect of ascorbic acid administration in hemodialysis patients on in vitro oxidative stress parameters: influence of serum ferritin levels. Am J Kidney Dis. 2003;42:158-166. View abstract.
  441. Connelly, A. E., Satia-Abouta, J., Martin, C. F., Keku, T. O., Woosley, J. T., Lund, P. K., and Sandler, R. S. Vitamin C intake and apoptosis in normal rectal epithelium. Cancer Epidemiol.Biomarkers Prev. 2003;12:559-565. View abstract.
  442. Keven, K., Kutlay, S., Nergizoglu, G., and Erturk, S. Randomized, crossover study of the effect of vitamin C on EPO response in hemodialysis patients. Am.J Kidney Dis. 2003;41:1233-1239. View abstract.
  443. Kelly, Y., Sacker, A., and Marmot, M. Nutrition and respiratory health in adults: findings from the health survey for Scotland. Eur.Respir.J 2003;21:664-671. View abstract.
  444. Steyn, P. S., Odendaal, H. J., Schoeman, J., Stander, C., Fanie, N., and Grove, D. A randomised, double-blind placebo-controlled trial of ascorbic acid supplementation for the prevention of preterm labour. J Obstet Gynaecol 2003;23:150-155. View abstract.
  445. Mai, V., Flood, A., Peters, U., Lacey, J. V., Jr., Schairer, C., and Schatzkin, A. Dietary fibre and risk of colorectal cancer in the Breast Cancer Detection Demonstration Project (BCDDP) follow-up cohort. Int J Epidemiol. 2003;32:234-239. View abstract.
  446. Grodstein, F., Chen, J., and Willett, W. C. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am.J Clin.Nutr 2003;77:975-984. View abstract.
  447. Ushiyama, Y., Matsumoto, K., Shinohara, M., Wakiguchi, H., Sakai, K., Komatsu, T., and Yamamoto, S. Nutrition during pregnancy may be associated with allergic diseases in infants. J Nutr Sci Vitaminol.(Tokyo) 2002;48:345-351. View abstract.
  448. Vinson, J. A. and Jang, J. In Vitro and In Vivo Lipoprotein Antioxidant Effect of a Citrus Extract and Ascorbic Acid on Normal and Hypercholesterolemic Human Subjects. J Med Food 2001;4:187-192. View abstract.
  449. Cross, J. M., Donald, A. E., Nuttall, S. L., Deanfield, J. E., Woolfson, R. G., and Macallister, R. J. Vitamin C improves resistance but not conduit artery endothelial function in patients with chronic renal failure. Kidney Int 2003;63:1433-1442. View abstract.
  450. Palmer, F. M., Nieman, D. C., Henson, D. A., McAnulty, S. R., McAnulty, L., Swick, N. S., Utter, A. C., Vinci, D. M., and Morrow, J. D. Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon. Eur.J Appl.Physiol 2003;89:100-107. View abstract.
  451. Antova, T., Pattenden, S., Nikiforov, B., Leonardi, G. S., Boeva, B., Fletcher, T., Rudnai, P., Slachtova, H., Tabak, C., Zlotkowska, R., Houthuijs, D., Brunekreef, B., and Holikova, J. Nutrition and respiratory health in children in six Central and Eastern European countries. Thorax 2003;58:231-236. View abstract.
  452. Forli, L., Pedersen, J. I., Bjortuft, O., Blomhoff, R., Kofstad, J., and Boe, J. Vitamins A and E in serum in relation to weight and lung function in patients with advanced pulmonary disease. Int J Vitam.Nutr Res 2002;72:360-368. View abstract.
  453. Omenaas, E., Fluge, O., Buist, A. S., Vollmer, W. M., and Gulsvik, A. Dietary vitamin C intake is inversely related to cough and wheeze in young smokers. Respir.Med 2003;97:134-142. View abstract.
  454. Nightingale, A. K., Blackman, D. J., Field, R., Glover, N. J., Pegge, N., Mumford, C., Schmitt, M., Ellis, G. R., Morris-Thurgood, J. A., and Frenneaux, M. P. Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure. Clin.Sci (Lond) 2003;104:529-535. View abstract.
  455. Kagawa, T., Takemura, G., Qiu, X., Maruyama, R., Wang, N., Minatoguchi, S., and Fujiwara, H. Hydroxyl radical generation by the combination of iron and ascorbic acid is greatly attenuated but still significant in human gastric juice. Intern.Med 2002;41:1213-1214. View abstract.
  456. Wilson, C. W., Greene, M., and Loh, H. S. The metabolism of supplementary vitamin C during the common cold. J Clin.Pharmacol. 1976;16:19-29. View abstract.
  457. Wu, K., Willett, W. C., Chan, J. M., Fuchs, C. S., Colditz, G. A., Rimm, E. B., and Giovannucci, E. L. A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men. Cancer Epidemiol.Biomarkers Prev. 2002;11:1298-1304. View abstract.
  458. Zhang, S. M., Hernan, M. A., Chen, H., Spiegelman, D., Willett, W. C., and Ascherio, A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 10-22-2002;59:1161-1169. View abstract.
  459. Chuang, C. H., Sheu, B. S., Huang, A. H., Yang, H. B., and Wu, J. J. Vitamin C and E supplements to lansoprazole-amoxicillin-metronidazole triple therapy may reduce the eradication rate of metronidazole-susceptible Helicobacter pylori infection. Helicobacter. 2002;7:310-316. View abstract.
  460. Bollschweiler, E., Wolfgarten, E., Nowroth, T., Rosendahl, U., Monig, S. P., and Holscher, A. H. Vitamin intake and risk of subtypes of esophageal cancer in Germany. J Cancer Res Clin Oncol 2002;128:575-580. View abstract.
  461. Darko, D., Dornhorst, A., Kelly, F. J., Ritter, J. M., and Chowienczyk, P. J. Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes. Clin.Sci (Lond) 2002;103:339-344. View abstract.
  462. Singh, N., Graves, J., Taylor, P. D., Macallister, R. J., and Singer, D. R. Effects of a 'healthy' diet and of acute and long-term vitamin C on vascular function in healthy older subjects. Cardiovasc.Res 2002;56:118-125. View abstract.
  463. Chen, H., Tucker, K. L., Graubard, B. I., Heineman, E. F., Markin, R. S., Potischman, N. A., Russell, R. M., Weisenburger, D. D., and Ward, M. H. Nutrient intakes and adenocarcinoma of the esophagus and distal stomach. Nutr Cancer 2002;42:33-40. View abstract.
  464. Sieri, S., Krogh, V., Muti, P., Micheli, A., Pala, V., Crosignani, P., and Berrino, F. Fat and protein intake and subsequent breast cancer risk in postmenopausal women. Nutr Cancer 2002;42:10-17. View abstract.
  465. White, K. L., Chalmers, D. M., Martin, I. G., Everett, S. M., Neville, P. M., Naylor, G., Sutcliffe, A. E., Dixon, M. F., Turner, P. C., and Schorah, C. J. Dietary antioxidants and DNA damage in patients on long-term acid-suppression therapy: a randomized controlled study. Br J Nutr 2002;88:265-271. View abstract.
  466. Van Straten, M. and Josling, P. Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey. Adv.Ther. 2002;19:151-159. View abstract.
  467. Arora, P., Kumar, V., and Batra, S. Vitamin A status in children with asthma. Pediatr.Allergy Immunol. 2002;13:223-226. View abstract.
  468. Hajjar, I. M., George, V., Sasse, E. A., and Kochar, M. S. A randomized, double-blind, controlled trial of vitamin C in the management of hypertension and lipids. Am.J Ther. 2002;9:289-293. View abstract.
  469. Taylor, H. R., Tikellis, G., Robman, L. D., McCarty, C. A., and McNeil, J. J. Vitamin E supplementation and macular degeneration: randomised controlled trial. BMJ 7-6-2002;325:11. View abstract.
  470. Menne, I. V., Grey, P. C., Kotze, J. P., Sommers, D. K., Brown, J. M., and Spies, J. H. Ascorbic acid and blood lipid and uric acid levels of students. S.Afr.Med J 12-20-1975;49:2225-2228. View abstract.
  471. Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Aggarwal, N., Wilson, R. S., and Scherr, P. A. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 6-26-2002;287:3230-3237. View abstract.
  472. Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., van Swieten, J. C., Hofman, A., Witteman, J. C., and Breteler, M. M. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 6-26-2002;287:3223-3229. View abstract.
  473. McKeever, T. M., Scrivener, S., Broadfield, E., Jones, Z., Britton, J., and Lewis, S. A. Prospective study of diet and decline in lung function in a general population. Am.J Respir.Crit Care Med 5-1-2002;165:1299-1303. View abstract.
  474. Asplund, K. Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review. J Intern.Med 2002;251:372-392. View abstract.
  475. Candan, F., Gultekin, F., and Candan, F. Effect of vitamin C and zinc on osmotic fragility and lipid peroxidation in zinc-deficient haemodialysis patients. Cell Biochem.Funct. 2002;20:95-98. View abstract.
  476. Nieman, D. C., Henson, D. A., McAnulty, S. R., McAnulty, L., Swick, N. S., Utter, A. C., Vinci, D. M., Opiela, S. J., and Morrow, J. D. Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl.Physiol 2002;92:1970-1977. View abstract.
  477. Sezer, S., Ozdemir, F. N., Yakupoglu, U., Arat, Z., Turan, M., and Haberal, M. Intravenous ascorbic acid administration for erythropoietin-hyporesponsive anemia in iron loaded hemodialysis patients. Artif.Organs 2002;26:366-370. View abstract.
  478. Martinez-Abundis, E., Pascoe-Gonzalez, S., Gonzalez-Ortiz, M., Mora-Martinez, J. M., and Cabrera-Pivaral, C. E. [Effect of oral administration of ascorbic acid on insulin sensitivity and lipid profile in obese individuals]. Rev Invest Clin. 2001;53:505-510. View abstract.
  479. Everett, S. M., Drake, I. M., White, K. L., Mapstone, N. P., Chalmers, D. M., Schorah, C. J., and Axon, A. T. Antioxidant vitamin supplements do not reduce reactive oxygen species activity in Helicobacter pylori gastritis in the short term. Br.J Nutr 2002;87:3-11. View abstract.
  480. Li, W., Zhu, Y., Yan, X., Zhang, Q., Li, X., Ni, Z., Shen, Z., Yao, H., and Zhu, J. [The prevention of primary liver cancer by selenium in high risk populations]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2000;34:336-338. View abstract.
  481. Terry, P., Jain, M., Miller, A. B., Howe, G. R., and Rohan, T. E. Dietary intake of folic acid and colorectal cancer risk in a cohort of women. Int J Cancer 2-20-2002;97:864-867. View abstract.
  482. Shaheen, S. O., Sterne, J. A., Thompson, R. L., Songhurst, C. E., Margetts, B. M., and Burney, P. G. Dietary antioxidants and asthma in adults: population-based case-control study. Am.J Respir.Crit Care Med 11-15-2001;164(10 Pt 1):1823-1828. View abstract.
  483. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. Am.J Ophthalmol. 2001;132:668-681. View abstract.
  484. Rossig, L., Hoffmann, J., Hugel, B., Mallat, Z., Haase, A., Freyssinet, J. M., Tedgui, A., Aicher, A., Zeiher, A. M., and Dimmeler, S. Vitamin C inhibits endothelial cell apoptosis in congestive heart failure. Circulation 10-30-2001;104:2182-2187. View abstract.
  485. Carnes, C. A., Chung, M. K., Nakayama, T., Nakayama, H., Baliga, R. S., Piao, S., Kanderian, A., Pavia, S., Hamlin, R. L., McCarthy, P. M., Bauer, J. A., and Van Wagoner, D. R. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ.Res 9-14-2001;89:E32-E38. View abstract.
  486. Ross, E. V., Miller, C., Meehan, K., Pac, McKinlay, J., Sajben, P., Trafeli, J. P., and Barnette, D. J. One-pass CO2 versus multiple-pass Er:YAG laser resurfacing in the treatment of rhytides: a comparison side-by-side study of pulsed CO2 and Er:YAG lasers. Dermatol.Surg. 2001;27:709-715. View abstract.
  487. Kontush, A., Mann, U., Arlt, S., Ujeyl, A., Luhrs, C., Muller-Thomsen, T., and Beisiegel, U. Influence of vitamin E and C supplementation on lipoprotein oxidation in patients with Alzheimer's disease. Free Radic.Biol.Med 8-1-2001;31:345-354. View abstract.
  488. Omata, N., Tsukahara, H., Ito, S., Ohshima, Y., Yasutomi, M., Yamada, A., Jiang, M., Hiraoka, M., Nambu, M., Deguchi, Y., and Mayumi, M. Increased oxidative stress in childhood atopic dermatitis. Life Sci 6-1-2001;69:223-228. View abstract.
  489. Ellwood, P., Asher, M. I., Bjorksten, B., Burr, M., Pearce, N., and Robertson, C. F. Diet and asthma, allergic rhinoconjunctivitis and atopic eczema symptom prevalence: an ecological analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) data. ISAAC Phase One Study Group. Eur.Respir.J 2001;17:436-443. View abstract.
  490. Pedersen, L. Biliary lipids during vitamin C feeding in healthy persons. Scand.J Gastroenterol. 1975;10:311-314. View abstract.
  491. Jain, M. G., Rohan, T. E., Howe, G. R., and Miller, A. B. A cohort study of nutritional factors and endometrial cancer. Eur.J Epidemiol. 2000;16:899-905. View abstract.
  492. Singhal, S., Gupta, R., and Goyle, A. Comparison of antioxidant efficacy of vitamin E, vitamin C, vitamin A and fruits in coronary heart disease: a controlled trial. J Assoc.Physicians India 2001;49:327-331. View abstract.
  493. Terry, P., Giovannucci, E., Michels, K. B., Bergkvist, L., Hansen, H., Holmberg, L., and Wolk, A. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. J Natl.Cancer Inst. 4-4-2001;93:525-533. View abstract.
  494. Peters, E. M., Anderson, R., and Theron, A. J. Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners. Int J Sports Med 2001;22:120-126. View abstract.
  495. Krause, R., Patruta, S., Daxbock, F., Fladerer, P., Biegelmayer, C., and Wenisch, C. Effect of vitamin C on neutrophil function after high-intensity exercise. Eur.J Clin.Invest 2001;31:258-263. View abstract.
  496. Jacobs, E. J., Connell, C. J., Patel, A. V., Chao, A., Rodriguez, C., Seymour, J., McCullough, M. L., Calle, E. E., and Thun, M. J. Vitamin C and vitamin E supplement use and colorectal cancer mortality in a large American Cancer Society cohort. Cancer Epidemiol.Biomarkers Prev. 2001;10:17-23. View abstract.
  497. Duffy, S. J., Gokce, N., Holbrook, M., Hunter, L. M., Biegelsen, E. S., Huang, A., Keaney, J. F., Jr., and Vita, J. A. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am.J Physiol Heart Circ.Physiol 2001;280:H528-H534. View abstract.
  498. Davidsson, L., Walczyk, T., Zavaleta, N., and Hurrell, R. Improving iron absorption from a Peruvian school breakfast meal by adding ascorbic acid or Na2EDTA. Am.J.Clin.Nutr. 2001;73:283-287. View abstract.
  499. McCann, S. E., Freudenheim, J. L., Marshall, J. R., Brasure, J. R., Swanson, M. K., and Graham, S. Diet in the epidemiology of endometrial cancer in western New York (United States). Cancer Causes Control 2000;11:965-974. View abstract.
  500. Giancaspro, V., Nuzziello, M., Pallotta, G., Sacchetti, A., and Petrarulo, F. Intravenous ascorbic acid in hemodialysis patients with functional iron deficiency: a clinical trial. J Nephrol. 2000;13:444-449. View abstract.
  501. Kitzmiller, W. J., Visscher, M., Page, D. A., Wicket, R. R., Kitzmiller, K. W., and Singer, L. J. A controlled evaluation of dermabrasion versus CO2 laser resurfacing for the treatment of perioral wrinkles. Plast.Reconstr.Surg. 2000;106:1366-1372. View abstract.
  502. Lewis, T. L., Karlowski, T. R., Kapikian, A. Z., Lynch, J. M., Shaffer, G. W., and George, D. A. A controlled clinical trial of ascorbic acid for the common cold. Ann.N.Y Acad.Sci 9-30-1975;258:505-512. View abstract.
  503. Tofler, G. H., Stec, J. J., Stubbe, I., Beadle, J., Feng, D., Lipinska, I., and Taylor, A. The effect of vitamin C supplementation on coagulability and lipid levels in healthy male subjects. Thromb.Res 10-1-2000;100:35-41. View abstract.
  504. Sargeant, L. A., Jaeckel, A., and Wareham, N. J. Interaction of vitamin C with the relation between smoking and obstructive airways disease in EPIC Norfolk. European Prospective Investigation into Cancer and Nutrition. Eur.Respir.J 2000;16:397-403. View abstract.
  505. Clegg, K. M. and Macdonald, J. M. L-Ascorbic acid and D-isoascorbic acid in a common cold survey. Am.J Clin.Nutr 1975;28:973-976. View abstract.
  506. Hijazi, N., Abalkhail, B., and Seaton, A. Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax 2000;55:775-779. View abstract.
  507. Wilson, L. G. The clinical definition of scurvy and the discovery of vitamin C. J Hist Med Allied Sci 1975;30:40-60. View abstract.
  508. Terry, P., Lagergren, J., Ye, W., Nyren, O., and Wolk, A. Antioxidants and cancers of the esophagus and gastric cardia. Int J Cancer 9-1-2000;87:750-754. View abstract.
  509. Huang, H. Y., Helzlsouer, K. J., and Appel, L. J. The effects of vitamin C and vitamin E on oxidative DNA damage: results from a randomized controlled trial. Cancer Epidemiol.Biomarkers Prev. 2000;9:647-652. View abstract.
  510. Anderson, T. W., Beaton, G. H., Corey, P., and Spero, L. Winter illness and vitamin C: the effect of relatively low doses. Can.Med Assoc.J 4-5-1975;112:823-826. View abstract.
  511. Cheng, K. K., Sharp, L., McKinney, P. A., Logan, R. F., Chilvers, C. E., Cook-Mozaffari, P., Ahmed, A., and Day, N. E. A case-control study of oesophageal adenocarcinoma in women: a preventable disease. Br J Cancer 2000;83:127-132. View abstract.
  512. Pedersen, B. K., Helge, J. W., Richter, E. A., Rohde, T., and Kiens, B. Training and natural immunity: effects of diets rich in fat or carbohydrate. Eur.J Appl.Physiol 2000;82(1-2):98-102. View abstract.
  513. Holmkvist, K. A. and Rogers, G. S. Treatment of perioral rhytides: a comparison of dermabrasion and superpulsed carbon dioxide laser. Arch.Dermatol. 2000;136:725-731. View abstract.
  514. Ekstrom, A. M., Serafini, M., Nyren, O., Hansson, L. E., Ye, W., and Wolk, A. Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden. Int J Cancer 7-1-2000;87:133-140. View abstract.
  515. Hu, G. and Cassano, P. A. Antioxidant nutrients and pulmonary function: the Third National Health and Nutrition Examination Survey (NHANES III). Am.J Epidemiol. 5-15-2000;151:975-981. View abstract.
  516. Bodner, C., Godden, D., Brown, K., Little, J., Ross, S., and Seaton, A. Antioxidant intake and adult-onset wheeze: a case-control study. Aberdeen WHEASE Study Group. Eur.Respir.J 1999;13:22-30. View abstract.
  517. Jain, M. G., Howe, G. R., and Rohan, T. E. Nutritional factors and endometrial cancer in Ontario, Canada. Cancer Control 2000;7:288-296. View abstract.
  518. Mahomed, K. Zinc supplementation in pregnancy. Cochrane.Database.Syst.Rev 2000;:CD000230. View abstract.
  519. Fotherby, M. D., Williams, J. C., Forster, L. A., Craner, P., and Ferns, G. A. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hypertens. 2000;18:411-415. View abstract.
  520. Rolla, G., Brussino, L., Carra, R., Garbella, E., and Bucca, C. Hypertension and ascorbic acid. Lancet 4-8-2000;355:1271-1272. View abstract.
  521. Tanaka, H., Matsuda, T., Miyagantani, Y., Yukioka, T., Matsuda, H., and Shimazaki, S. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch.Surg. 2000;135:326-331. View abstract.
  522. Grievink, L., de Waart, F. G., Schouten, E. G., and Kok, F. J. Serum carotenoids, alpha-tocopherol, and lung function among Dutch elderly. Am.J Respir.Crit Care Med 2000;161(3 Pt 1):790-795. View abstract.
  523. Newman, J. B., Lord, J. L., Ash, K., and McDaniel, D. H. Variable pulse erbium:YAG laser skin resurfacing of perioral rhytides and side-by-side comparison with carbon dioxide laser. Lasers Surg.Med 2000;26:208-214. View abstract.
  524. Bourdel-Marchasson, I., Barateau, M., Rondeau, V., Dequae-Merchadou, L., Salles-Montaudon, N., Emeriau, J. P., Manciet, G., and Dartigues, J. F. A multi-center trial of the effects of oral nutritional supplementation in critically ill older inpatients. GAGE Group. Groupe Aquitain Geriatrique d'Evaluation. Nutrition 2000;16:1-5. View abstract.
  525. Johnson, C. C., Gorell, J. M., Rybicki, B. A., Sanders, K., and Peterson, E. L. Adult nutrient intake as a risk factor for Parkinson's disease. Int J Epidemiol. 1999;28:1102-1109. View abstract.
  526. Robman, L. D., Tikellis, G., Garrett, S. K., Harper, C. A., McNeil, J. J., Taylor, H. R., and McCarty, C. A. Baseline ophthalmic findings in the vitamin E, cataract and age-related maculopathy (VECAT) study. Aust.N.Z.J Ophthalmol. 1999;27:410-416. View abstract.
  527. Maddin, S., Lauharanta, J., Agache, P., Burrows, L., Zultak, M., and Bulger, L. Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. J Am.Acad.Dermatol. 2000;42(1 Pt 1):56-63. View abstract.
  528. Ginter, E. Ascorbic acid in cholesterol and bile acid metabolism. Ann.N.Y Acad.Sci 9-30-1975;258:410-421. View abstract.
  529. The Age-Related Eye Disease Study (AREDS): design implications. AREDS report no. 1. Control Clin.Trials 1999;20:573-600. View abstract.
  530. Grievink, L., Smit, H. A., Veer, P., Brunekreef, B., and Kromhout, D. Plasma concentrations of the antioxidants beta-carotene and alpha-tocopherol in relation to lung function. Eur.J Clin.Nutr 1999;53:813-817. View abstract.
  531. Tabak, C., Smit, H. A., Rasanen, L., Fidanza, F., Menotti, A., Nissinen, A., Feskens, E. J., Heederik, D., and Kromhout, D. Dietary factors and pulmonary function: a cross sectional study in middle aged men from three European countries. Thorax 1999;54:1021-1026. View abstract.
  532. Garrett, S. K., McNeil, J. J., Silagy, C., Sinclair, M., Thomas, A. P., Robman, L. P., McCarty, C. A., Tikellis, G., and Taylor, H. R. Methodology of the VECAT study: vitamin E intervention in cataract and age-related maculopathy. Ophthalmic Epidemiol. 1999;6:195-208. View abstract.
  533. Marchioli, R. Antioxidant vitamins and prevention of cardiovascular disease: laboratory, epidemiological and clinical trial data. Pharmacol.Res 1999;40:227-238. View abstract.
  534. Gin, I., Chew, J., Rau, K. A., Amos, D. B., and Bridenstine, J. B. Treatment of upper lip wrinkles: a comparison of the 950 microsec dwell time carbon dioxide laser to manual tumescent dermabrasion. Dermatol.Surg. 1999;25:468-473. View abstract.
  535. McDaniel, D. H., Lord, J., Ash, K., and Newman, J. Combined CO2/erbium:YAG laser resurfacing of peri-oral rhytides and side-by-side comparison with carbon dioxide laser alone. Dermatol.Surg. 1999;25:285-293. View abstract.
  536. Chew, J., Gin, I., Rau, K. A., Amos, D. B., and Bridenstine, J. B. Treatment of upper lip wrinkles: a comparison of 950 microsec dwell time carbon dioxide laser with unoccluded Baker's phenol chemical peel. Dermatol.Surg. 1999;25:262-266. View abstract.
  537. Gokce, N., Keaney, J. F., Jr., Frei, B., Holbrook, M., Olesiak, M., Zachariah, B. J., Leeuwenburgh, C., Heinecke, J. W., and Vita, J. A. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 6-29-1999;99:3234-3240. View abstract.
  538. Kontush, A., Spranger, T., Reich, A., Baum, K., and Beisiegel, U. Lipophilic antioxidants in blood plasma as markers of atherosclerosis: the role of alpha-carotene and gamma-tocopherol. Atherosclerosis 1999;144:117-122. View abstract.
  539. de Valk, H. W., Hardus, P. L., van Rijn, H. J., and Erkelens, D. W. Plasma magnesium concentration and progression of retinopathy. Diabetes Care 1999;22:864-865. View abstract.
  540. MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience. Eur.Heart J 1999;20:725-741. View abstract.
  541. Gazis, A., White, D. J., Page, S. R., and Cockcroft, J. R. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus. Diabet.Med 1999;16:304-311. View abstract.
  542. Singh, A., Papanicolaou, D. A., Lawrence, L. L., Howell, E. A., Chrousos, G. P., and Deuster, P. A. Neuroendocrine responses to running in women after zinc and vitamin E supplementation. Med Sci Sports Exerc. 1999;31:536-542. View abstract.
  543. Khatri, K. A., Ross, V., Grevelink, J. M., Magro, C. M., and Anderson, R. R. Comparison of erbium:YAG and carbon dioxide lasers in resurfacing of facial rhytides. Arch.Dermatol. 1999;135:391-397. View abstract.
  544. Hartgrink, H. H., Wille, J., Konig, P., Hermans, J., and Breslau, P. J. Pressure sores and tube feeding in patients with a fracture of the hip: a randomized clinical trial. Clin.Nutr 1998;17:287-292. View abstract.
  545. Ferlin MLS, Chuan LS, Jorge SM, and Vannucchi H. Early anemia of prematurity. Nutr.Res 1998;18:1161-1173.
  546. Blanchette V, Bell E, Nahmias C, Garnett S, Milner R, and Zipursky A. A randomized control trial of vitamin E therapy in the prevention of anemia in low birth weight (LBW) infants. Pediatr.Res 1980;14:591.
  547. Dror, D. K. and Allen, L. H. Interventions with vitamins B6, B12 and C in pregnancy. Paediatr.Perinat.Epidemiol. 2012;26 Suppl 1:55-74. View abstract.
  548. Grajecki, D., Zyriax, B. C., and Buhling, K. J. The effect of micronutrient supplements on female fertility: a systematic review. Arch.Gynecol.Obstet. 2012;285:1463-1471. View abstract.
  549. Tomoda, H., Yoshitake, M., Morimoto, K., and Aoki, N. Possible prevention of postangioplasty restenosis by ascorbic acid. Am.J Cardiol. 12-1-1996;78:1284-1286. View abstract.
  550. Buzina, R., Grgic, Z., Jusic, M., Sapunar, J., Milanovic, N., and Brubacher, G. Nutritional status and physical working capacity. Hum.Nutr Clin.Nutr 1982;36:429-438. View abstract.
  551. Suboticanec-Buzina, K., Buzina, R., Brubacher, G., Sapunar, J., and Christeller, S. Vitamin C status and physical working capacity in adolescents. Int J Vitam.Nutr Res. 1984;54:55-60. View abstract.
  552. Das, B. K., Bal, M. S., Tripathi, A. M., Singla, P. N., Agarwal, D. K., and Agarwal, K. N. Evaluation of frequency and dose of iron and other hematinics--an alternative strategy for anemia prophylaxis in rural preschoolers. Indian Pediatr. 1984;21:933-938. View abstract.
  553. Reinken, L. and Kurz, R. [The treatment of anemia due to iron-deficiency with iron combined with vitamins (author's transl)]. Klin.Padiatr. 1978;190:163-167. View abstract.
  554. Buzina, R., Jusic, M., Milanovic, N., Sapunar, J., and Brubacher, G. The effects of riboflavin administration on iron metabolism parameters in a school-going population. Int J Vitam.Nutr Res. 1979;49:136-143. View abstract.
  555. Seshadri, S., Shah, A., and Bhade, S. Haematologic response of anaemic preschool children to ascorbic acid supplementation. Hum.Nutr Appl.Nutr 1985;39:151-154. View abstract.
  556. Conway, S. P., Rawson, I., Dear, P. R., Shires, S. E., and Kelleher, J. The early anaemia of the premature infant: is there a place for vitamin E supplementation? Br J Nutr 1986;56:105-114. View abstract.
  557. Decker, K., Dotis, B., Glatzle, D., and Hinselmann, M. Riboflavin status and anaemia in pregnant women. Nutr Metab 1977;21 Suppl 1:17-19. View abstract.
  558. Ajayi, O. A., Okike, O. C., and Yusuf, Y. Haematological response to supplements of riboflavin and ascorbic acid in Nigerian young adults. Eur.J Haematol. 1990;44:209-212. View abstract.
  559. Hunt, J. R., Mullen, L. M., Lykken, G. I., Gallagher, S. K., and Nielsen, F. H. Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am.J Clin.Nutr 1990;51:649-655. View abstract.
  560. Mao, X. and Yao, G. Effect of vitamin C supplementations on iron deficiency anemia in Chinese children. Biomed.Environ Sci. 1992;5:125-129. View abstract.
  561. DeMaio, S. J., King, S. B., III, Lembo, N. J., Roubin, G. S., Hearn, J. A., Bhagavan, H. N., and Sgoutas, D. S. Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary angioplasty (PTCA). J Am.Coll.Nutr 1992;11:68-73. View abstract.
  562. Zureik, M., Galan, P., Bertrais, S., Mennen, L., Czernichow, S., Blacher, J., Ducimetiere, P., and Hercberg, S. Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arterioscler.Thromb.Vasc.Biol. 2004;24:1485-1491. View abstract.
  563. Hodis, H. N., Mack, W. J., LaBree, L., Mahrer, P. R., Sevanian, A., Liu, C. R., Liu, C. H., Hwang, J., Selzer, R. H., and Azen, S. P. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation 9-17-2002;106:1453-1459. View abstract.
  564. Reinken, L. and Kurz, R. [Activity studies of an iron-vitamin B6 preparation for euteral treatment of iron deficiency anemia]. Int J Vitam.Nutr Res. 1975;45:411-418. View abstract.
  565. Fang, J. C., Kinlay, S., Beltrame, J., Hikiti, H., Wainstein, M., Behrendt, D., Suh, J., Frei, B., Mudge, G. H., Selwyn, A. P., and Ganz, P. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial. Lancet 3-30-2002;359:1108-1113. View abstract.
  566. van Stuijvenberg, M. E., Kvalsvig, J. D., Faber, M., Kruger, M., Kenoyer, D. G., and Benade, A. J. Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. Am.J.Clin.Nutr. 1999;69:497-503. View abstract.
  567. Barel AO, Delune M, Clarys P, and Gabard B. Treatment of photodamaged facial skin with topical tretinoin: a blinded, vehiclecontrolled half-side study. Nouvelles Dermatologiques 1995;14:585-591.
  568. von, Herbay A., Stahl, W., Niederau, C., and Sies, H. Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study. Free Radic.Res 1997;27:599-605. View abstract.
  569. Moon, T. E., Levine, N., Cartmel, B., Bangert, J. L., Rodney, S., Dong, Q., Peng, Y. M., and Alberts, D. S. Effect of retinol in preventing squamous cell skin cancer in moderate-risk subjects: a randomized, double-blind, controlled trial. Southwest Skin Cancer Prevention Study Group. Cancer Epidemiol Biomarkers Prev. 1997;6:949-956. View abstract.
  570. Olsen, E. A., Katz, H. I., Levine, N., Nigra, T. P., Pochi, P. E., Savin, R. C., Shupack, J., Weinstein, G. D., Lufrano, L., and Perry, B. H. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol 1997;37(2 Pt 1):217-226. View abstract.
  571. Shatrugna, V., Raman, L., Uma, K., and Sujatha, T. Interaction between vitamin A and iron: effects of supplements in pregnancy. Int J Vitam.Nutr Res. 1997;67:145-148. View abstract.
  572. Yu, S. Y., Zhu, Y. J., and Li, W. G. Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol Trace Elem.Res 1997;56:117-124. View abstract.
  573. Hogarth, M. B., Marshall, P., Lovat, L. B., Palmer, A. J., Frost, C. G., Fletcher, A. E., Nicholl, C. G., and Bulpitt, C. J. Nutritional supplementation in elderly medical in-patients: a double-blind placebo-controlled trial. Age Ageing 1996;25:453-457. View abstract.
  574. Verhoeven, D. T., Assen, N., Goldbohm, R. A., Dorant, E., van, 't, V, Sturmans, F., Hermus, R. J., and Van den Brandt, P. A. Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. Br.J Cancer 1997;75:149-155. View abstract.
  575. Kushi, L. H., Fee, R. M., Sellers, T. A., Zheng, W., and Folsom, A. R. Intake of vitamins A, C, and E and postmenopausal breast cancer. The Iowa Women's Health Study. Am J Epidemiol 7-15-1996;144:165-174. View abstract.
  576. Chawla, P. K. and Puri, R. Impact of nutritional supplements on hematological profile of pregnant women. Indian Pediatr. 1995;32:876-880. View abstract.
  577. Negri, E., La, Vecchia C., Franceschi, S., D'Avanzo, B., Talamini, R., Parpinel, M., Ferraroni, M., Filiberti, R., Montella, M., Falcini, F., Conti, E., and Decarli, A. Intake of selected micronutrients and the risk of breast cancer. Int J Cancer 1-17-1996;65:140-144. View abstract.
  578. Andreano, J. M., Bergfeld, W. F., and Medendorp, S. V. Tretinoin emollient cream 0.01% for the treatment of photoaged skin. Cleve.Clin J Med 1993;60:49-55. View abstract.
  579. Butcher, G. P., Rhodes, J. M., Walker, R., Krasner, N., and Jackson, M. J. The effect of antioxidant supplementation on a serum marker of free radical activity and abnormal serum biochemistry in alcoholic patients admitted for detoxification. J Hepatol. 1993;19:105-109. View abstract.
  580. Lowe, P. M., Woods, J., Lewis, A., Davies, A., and Cooper, A. J. Topical tretinoin improves the appearance of photo damaged skin. Australas.J Dermatol 1994;35:1-9. View abstract.
  581. de la Maza, M. P., Petermann, M., Bunout, D., and Hirsch, S. Effects of long-term vitamin E supplementation in alcoholic cirrhotics. J Am Coll Nutr 1995;14:192-196. View abstract.
  582. Pike, J. and Chandra, R. K. Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int J Vitam Nutr Res 1995;65:117-121. View abstract.
  583. Meyskens, F. L., Jr., Kopecky, K. J., Appelbaum, F. R., Balcerzak, S. P., Samlowski, W., and Hynes, H. Effects of vitamin A on survival in patients with chronic myelogenous leukemia: a SWOG randomized trial. Leuk.Res 1995;19:605-612. View abstract.
  584. Griffiths, C. E., Kang, S., Ellis, C. N., Kim, K. J., Finkel, L. J., Ortiz-Ferrer, L. C., White, G. M., Hamilton, T. A., and Voorhees, J. J. Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams. Arch Dermatol 1995;131:1037-1044. View abstract.
  585. Hopkins, R., Bird, H. A., Jones, H., Hill, J., Surrall, K. E., Astbury, C., Miller, A., and Wright, V. A double-blind controlled trial of etretinate (Tigason) and ibuprofen in psoriatic arthritis. Ann Rheum Dis 1985;44:189-193. View abstract.
  586. Worner, T. M., Gordon, G. G., Leo, M. A., and Lieber, C. S. Vitamin A treatment of sexual dysfunction in male alcoholics. Am J Clin Nutr 1988;48:1431-1435. View abstract.
  587. Muhilal, Permeisih, D., Idjradinata, Y. R., Muherdiyantiningsih, and Karyadi, D. Vitamin A-fortified monosodium glutamate and health, growth, and survival of children: a controlled field trial. Am J Clin Nutr 1988;48:1271-1276. View abstract.
  588. Bloem, M. W., Wedel, M., Egger, R. J., Speek, A. J., Schrijver, J., Saowakontha, S., and Schreurs, W. H. Iron metabolism and vitamin A deficiency in children in northeast Thailand. Am.J Clin.Nutr 1989;50:332-338. View abstract.
  589. Leyden, J. J., Grove, G. L., Grove, M. J., Thorne, E. G., and Lufrano, L. Treatment of photodamaged facial skin with topical tretinoin. J Am Acad Dermatol 1989;21(3 Pt 2):638-644. View abstract.
  590. Iscovich, J. M., Iscovich, R. B., Howe, G., Shiboski, S., and Kaldor, J. M. A case-control study of diet and breast cancer in Argentina. Int J Cancer 11-15-1989;44:770-776. View abstract.
  591. Bloem, M. W., Wedel, M., van Agtmaal, E. J., Speek, A. J., Saowakontha, S., and Schreurs, W. H. Vitamin A intervention: short-term effects of a single, oral, massive dose on iron metabolism. Am.J Clin.Nutr 1990;51:76-79. View abstract.
  592. Panth, M., Shatrugna, V., Yasodhara, P., and Sivakumar, B. Effect of vitamin A supplementation on haemoglobin and vitamin A levels during pregnancy. Br J Nutr 1990;64:351-358. View abstract.
  593. Kerscher, M. and Buntrock, H. [Anti-aging creams. What really helps?]. Hautarzt 2011;62:607-613. View abstract.
  594. Rumbold, A., Middleton, P., Pan, N., and Crowther, C. A. Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev 2011;:CD004073. View abstract.
  595. Weinstein, G. D., Nigra, T. P., Pochi, P. E., Savin, R. C., Allan, A., Benik, K., Jeffes, E., Lufrano, L., and Thorne, E. G. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol 1991;127:659-665. View abstract.
  596. Richardson, S., Gerber, M., and Cenee, S. The role of fat, animal protein and some vitamin consumption in breast cancer: a case control study in southern France. Int J Cancer 4-22-1991;48:1-9. View abstract.
  597. Penn, N. D., Purkins, L., Kelleher, J., Heatley, R. V., Mascie-Taylor, B. H., and Belfield, P. W. The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing 1991;20:169-174. View abstract.
  598. Gabbay, E., Zigmond, E., Pappo, O., Hemed, N., Rowe, M., Zabrecky, G., Cohen, R., and Ilan, Y. Antioxidant therapy for chronic hepatitis C after failure of interferon: results of phase II randomized, double-blind placebo controlled clinical trial. World J Gastroenterol 10-28-2007;13:5317-5323. View abstract.
  599. Canter, P. H., Wider, B., and Ernst, E. The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials. Rheumatology.(Oxford) 2007;46:1223-1233. View abstract.
  600. Rafal, E. S., Griffiths, C. E., Ditre, C. M., Finkel, L. J., Hamilton, T. A., Ellis, C. N., and Voorhees, J. J. Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. N Engl.J Med 2-6-1992;326:368-374. View abstract.
  601. Hino, K., Murakami, Y., Nagai, A., Kitase, A., Hara, Y., Furutani, T., Ren, F., Yamaguchi, Y., Yutoku, K., Yamashita, S., Okuda, M., Okita, M., and Okita, K. Alpha-tocopherol [corrected] and ascorbic acid attenuates the ribavirin [corrected] induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients. J Gastroenterol Hepatol. 2006;21:1269-1275. View abstract.
  602. van den Broek, N. R., White, S. A., Flowers, C., Cook, J. D., Letsky, E. A., Tanumihardjo, S. A., Mhango, C., Molyneux, M., and Neilson, J. P. Randomised trial of vitamin A supplementation in pregnant women in rural Malawi found to be anaemic on screening by HemoCue. BJOG. 2006;113:569-576. View abstract.
  603. Hernandez-Guerra, M., Garcia-Pagan, J. C., Turnes, J., Bellot, P., Deulofeu, R., Abraldes, J. G., and Bosch, J. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension. Hepatology 2006;43:485-491. View abstract.
  604. Avenell, A., Campbell, M. K., Cook, J. A., Hannaford, P. C., Kilonzo, M. M., McNeill, G., Milne, A. C., Ramsay, C. R., Seymour, D. G., Stephen, A. I., and Vale, L. D. Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial. BMJ 8-6-2005;331:324-329. View abstract.
  605. Rumbold, A., Middleton, P., and Crowther, C. A. Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev 2005;:CD004073. View abstract.
  606. Samuel, M., Brooke, R. C., Hollis, S., and Griffiths, C. E. Interventions for photodamaged skin. Cochrane Database Syst Rev 2005;:CD001782. View abstract.
  607. Saeian, K., Bajaj, J. S., Franco, J., Knox, J. F., Daniel, J., Peine, C., McKee, D., Varma, R. R., and Ho, S. High-dose vitamin E supplementation does not diminish ribavirin-associated haemolysis in hepatitis C treatment with combination standard alpha-interferon and ribavirin. Aliment.Pharmacol.Ther 11-15-2004;20:1189-1193. View abstract.
  608. Olsen, E. A., Katz, H. I., Levine, N., Shupack, J., Billys, M. M., Prawer, S., Gold, J., Stiller, M., Lufrano, L., and Thorne, E. G. Tretinoin emollient cream: a new therapy for photodamaged skin. J Am Acad Dermatol 1992;26(2 Pt 1):215-224. View abstract.
  609. Takagi, H., Kakizaki, S., Sohara, N., Sato, K., Tsukioka, G., Tago, Y., Konaka, K., Kabeya, K., Kaneko, M., Takayama, H., Hashimoto, Y., Yamada, T., Takahashi, H., Shimojo, H., Nagamine, T., and Mori, M. Pilot clinical trial of the use of alpha-tocopherol for the prevention of hepatocellular carcinoma in patients with liver cirrhosis. Int J Vitam Nutr Res 2003;73:411-415. View abstract.
  610. Murphy, S., West, K. P., Jr., Greenough, W. B., III, Cherot, E., Katz, J., and Clement, L. Impact of vitamin A supplementation on the incidence of infection in elderly nursing-home residents: a randomized controlled trial. Age Ageing 1992;21:435-439. View abstract.
  611. Mezey, E., Potter, J. J., Rennie-Tankersley, L., Caballeria, J., and Pares, A. A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J Hepatol. 2004;40:40-46. View abstract.
  612. Mahmud, Z. and Ali, S. M. Role of vitamin A and E in spondylosis. Bangladesh Med Res Counc.Bull 1992;18:47-59. View abstract.
  613. Graham, S., Zielezny, M., Marshall, J., Priore, R., Freudenheim, J., Brasure, J., Haughey, B., Nasca, P., and Zdeb, M. Diet in the epidemiology of postmenopausal breast cancer in the New York State Cohort. Am J Epidemiol 12-1-1992;136:1327-1337. View abstract.
  614. Gueguen, S., Pirollet, P., Leroy, P., Guilland, J. C., Arnaud, J., Paille, F., Siest, G., Visvikis, S., Hercberg, S., and Herbeth, B. Changes in serum retinol, alpha-tocopherol, vitamin C, carotenoids, xinc and selenium after micronutrient supplementation during alcohol rehabilitation. J.Am.Coll.Nutr. 2003;22:303-310. View abstract.
  615. Kumwenda, N., Miotti, P. G., Taha, T. E., Broadhead, R., Biggar, R. J., Jackson, J. B., Melikian, G., and Semba, R. D. Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Clin Infect.Dis 9-1-2002;35:618-624. View abstract.
  616. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 7-6-2002;360:7-22. View abstract.
  617. Schmidt, M. K., Muslimatun, S., West, C. E., Schultink, W., and Hautvast, J. G. Vitamin A and iron supplementation of Indonesian pregnant women benefits vitamin A status of their infants. Br J Nutr 2001;86:607-615. View abstract.
  618. Kang, S., Leyden, J. J., Lowe, N. J., Ortonne, J. P., Phillips, T. J., Weinstein, G. D., Bhawan, J., Lew-Kaya, D. A., Matsumoto, R. M., Sefton, J., Walker, P. S., and Gibson, J. R. Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks. Arch Dermatol 2001;137:1597-1604. View abstract.
  619. Nyirady, J., Bergfeld, W., Ellis, C., Levine, N., Savin, R., Shavin, J., Voorhees, J. J., Weiss, J., and Grossman, R. Tretinoin cream 0.02% for the treatment of photodamaged facial skin: a review of 2 double-blind clinical studies. Cutis 2001;68:135-142. View abstract.
  620. Andreone, P., Fiorino, S., Cursaro, C., Gramenzi, A., Margotti, M., Di, Giammarino L., Biselli, M., Miniero, R., Gasbarrini, G., and Bernardi, M. Vitamin E as treatment for chronic hepatitis B: results of a randomized controlled pilot trial. Antiviral Res 2001;49:75-81. View abstract.
  621. Sefton, J., Kligman, A. M., Kopper, S. C., Lue, J. C., and Gibson, J. R. Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel. J Am Acad Dermatol 2000;43:656-663. View abstract.
  622. Ideo, G., Bellobuono, A., Tempini, S., Mondazzi, L., Airoldi, A., Benetti, G., Bissoli, F., Cestari, C., Colombo, E., Del, Poggio P., Fracassetti, O., Lazzaroni, S., Marelli, A., Paris, B., Prada, A., Rainer, E., and Roffi, L. Antioxidant drugs combined with alpha-interferon in chronic hepatitis C not responsive to alpha-interferon alone: a randomized, multicentre study. Eur J Gastroenterol Hepatol. 1999;11:1203-1207. View abstract.
  623. Look, M. P., Gerard, A., Rao, G. S., Sudhop, T., Fischer, H. P., Sauerbruch, T., and Spengler, U. Interferon/antioxidant combination therapy for chronic hepatitis C--a controlled pilot trial. Antiviral Res 1999;43:113-122. View abstract.
  624. Smith, J. C., Makdani, D., Hegar, A., Rao, D., and Douglass, L. W. Vitamin A and zinc supplementation of preschool children. J Am.Coll.Nutr 1999;18:213-222. View abstract.
  625. Kolsteren, P., Rahman, S. R., Hilderbrand, K., and Diniz, A. Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh. Eur.J Clin.Nutr 1999;53:102-106. View abstract.
  626. Heinle, K., Adam, A., Gradl, M., Wiseman, M., and Adam, O. [Selenium concentration in erythrocytes of patients with rheumatoid arthritis. Clinical and laboratory chemistry infection markers during administration of selenium]. Med Klin 9-15-1997;92 Suppl 3:29-31. View abstract.
  627. Han, L. and Zhou, S. M. Selenium supplement in the prevention of pregnancy induced hypertension. Chin Med J (Engl) 1994;107:870-871. View abstract.
  628. Van, Gossum A. and Neve, J. Low selenium status in alcoholic cirrhosis is correlated with aminopyrine breath test. Preliminary effects of selenium supplementation. Biol.Trace Elem.Res. 1995;47(1-3):201-207. View abstract.
  629. Portal, B., Richard, M. J., Coudray, C., Arnaud, J., and Favier, A. Effect of double-blind cross-over selenium supplementation on lipid peroxidation markers in cystic fibrosis patients. Clin.Chim.Acta 1-31-1995;234(1-2):137-146. View abstract.
  630. Hill, J. and Bird, H. A. Failure of selenium-ace to improve osteoarthritis. Br.J Rheumatol. 1990;29:211-213. View abstract.
  631. Burney, P., Potts, J., Makowska, J., Kowalski, M., Phillips, J., Gnatiuc, L., Shaheen, S., Joos, G., Van, Cauwenberge P., van, Zele T., Verbruggen, K., van, Durme Y., Derudder, I., Wohrl, S., Godnic-Cvar, J., Salameh, B., Skadhauge, L., Thomsen, G., Zuberbier, T., Bergmann, K. C., Heinzerling, L., Renz, H., Al-Fakhri, N., Kosche, B., Hildenberg, A., Papadopoulos, N. G., Xepapadaki, P., Zannikos, K., Gjomarkaj, M., Bruno, A., Pace, E., Bonini, S., Bresciani, M., Gramiccioni, C., Fokkens, W., Weersink, E. J., Carlsen, K. H., Bakkeheim, E., Loureiro, C., Villanueva, C. M., Sanjuas, C., Zock, J. P., Lundback, B., and Janson, C. A case-control study of the relation between plasma selenium and asthma in European populations: a GAL2EN project. Allergy 2008;63:865-871. View abstract.
  632. Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. Am.J Clin.Nutr. 1991;53:1222-1229. View abstract.
  633. Yu, S. Y., Zhu, Y. J., Li, W. G., Huang, Q. S., Huang, C. Z., Zhang, Q. N., and Hou, C. A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China. Biol.Trace Elem.Res. 1991;29:289-294. View abstract.
  634. Groenbaek, K., Friis, H., Hansen, M., Ring-Larsen, H., and Krarup, H. B. The effect of antioxidant supplementation on hepatitis C viral load, transaminases and oxidative status: a randomized trial among chronic hepatitis C virus-infected patients. Eur J Gastroenterol Hepatol 2006;18:985-989. View abstract.
  635. Peretz, A., Neve, J., Duchateau, J., and Famaey, J. P. Adjuvant treatment of recent onset rheumatoid arthritis by selenium supplementation: preliminary observations. Br.J Rheumatol. 1992;31:281-282. View abstract.
  636. Weijl, N. I., Elsendoorn, T. J., Lentjes, E. G., Hopman, G. D., Wipkink-Bakker, A., Zwinderman, A. H., Cleton, F. J., and Osanto, S. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur.J Cancer 2004;40:1713-1723. View abstract.
  637. Allsup, S. J., Shenkin, A., Gosney, M. A., Taylor, S., Taylor, W., Hammond, M., and Zambon, M. C. Can a short period of micronutrient supplementation in older institutionalized people improve response to influenza vaccine? A randomized, controlled trial. J Am.Geriatr.Soc. 2004;52:20-24. View abstract.
  638. Powers, H. J., Bates, C. J., Lamb, W. H., Singh, J., Gelman, W., and Webb, E. Effects of a multivitamin and iron supplement on running performance in Gambian children. Hum.Nutr Clin.Nutr 1985;39:427-437. View abstract.
  639. Munoz, N., Wahrendorf, J., Bang, L. J., Crespi, M., Thurnham, D. I., Day, N. E., Ji, Z. H., Grassi, A., Yan, L. W., Lin, L. G., and . No effect of riboflavine, retinol, and zinc on prevalence of precancerous lesions of oesophagus. Randomised double-blind intervention study in high-risk population of China. Lancet 7-20-1985;2:111-114. View abstract.
  640. Suboticanec, K., Stavljenic, A., Schalch, W., and Buzina, R. Effects of pyridoxine and riboflavin supplementation on physical fitness in young adolescents. Int J Vitam.Nutr Res. 1990;60:81-88. View abstract.
  641. Merchant, A. T., Msamanga, G., Villamor, E., Saathoff, E., O'brien, M., Hertzmark, E., Hunter, D. J., and Fawzi, W. W. Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension. J Nutr 2005;135:1776-1781. View abstract.
  642. Law, M. R. and Morris, J. K. By how much does fruit and vegetable consumption reduce the risk of ischaemic heart disease? Eur J Clin Nutr 1998;52:549-556. View abstract.
  643. Fehily, A. M., Yarnell, J. W., Sweetnam, P. M., and Elwood, P. C. Diet and incident ischaemic heart disease: the Caerphilly Study. Br J Nutr 1993;69:303-314. View abstract.
  644. Pandey, D. K., Shekelle, R., Selwyn, B. J., Tangney, C., and Stamler, J. Dietary vitamin C and beta-carotene and risk of death in middle-aged men. The Western Electric Study. Am J Epidemiol. 12-15-1995;142:1269-1278. View abstract.
  645. McCarty, M. F. Scavenging of peroxynitrite-derived radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetable intakes. Med Hypotheses 2008;70:170-181. View abstract.
  646. Fraser, G. E., Sabate, J., Beeson, W. L., and Strahan, T. M. A possible protective effect of nut consumption on risk of coronary heart disease. The Adventist Health Study. Arch Intern Med 1992;152:1416-1424. View abstract.
  647. Miedema, I., Feskens, E. J., Heederik, D., and Kromhout, D. Dietary determinants of long-term incidence of chronic nonspecific lung diseases. The Zutphen Study. Am J Epidemiol 7-1-1993;138:37-45. View abstract.
  648. Huang, S. L. and Pan, W. H. Dietary fats and asthma in teenagers: analyses of the first Nutrition and Health Survey in Taiwan (NAHSIT). Clin.Exp.Allergy 2001;31:1875-1880. View abstract.
  649. Rumiris, D., Purwosunu, Y., Wibowo, N., Farina, A., and Sekizawa, A. Lower rate of preeclampsia after antioxidant supplementation in pregnant women with low antioxidant status. Hypertens.Pregnancy. 2006;25:241-253. View abstract.
  650. Lamm, D. L., Riggs, D. R., Shriver, J. S., vanGilder, P. F., Rach, J. F., and DeHaven, J. I. Megadose vitamins in bladder cancer: a double-blind clinical trial. J Urol 1994;151:21-26. View abstract.
  651. Taylor, P. R., Li, B., Dawsey, S. M., Li, J. Y., Yang, C. S., Guo, W., and Blot, W. J. Prevention of esophageal cancer: the nutrition intervention trials in Linxian, China. Linxian Nutrition Intervention Trials Study Group. Cancer Res 4-1-1994;54(7 Suppl):2029s-2031s. View abstract.
  652. Blot, W. J., Li, J. Y., Taylor, P. R., Guo, W., Dawsey, S. M., and Li, B. The Linxian trials: mortality rates by vitamin-mineral intervention group. Am J Clin Nutr 1995;62(6 Suppl):1424S-1426S. View abstract.
  653. Poulter, J. M., White, W. F., and Dickerson, J. W. Ascorbic acid supplementation and five year survival rates in women with early breast cancer. Acta Vitaminol.Enzymol. 1984;6:175-182. View abstract.
  654. Virtamo, J., Edwards, B. K., Virtanen, M., Taylor, P. R., Malila, N., Albanes, D., Huttunen, J. K., Hartman, A. M., Hietanen, P., Maenpaa, H., Koss, L., Nordling, S., and Heinonen, O. P. Effects of supplemental alpha-tocopherol and beta-carotene on urinary tract cancer: incidence and mortality in a controlled trial (Finland). Cancer Causes Control 2000;11:933-939. View abstract.
  655. Albanes, D., Malila, N., Taylor, P. R., Huttunen, J. K., Virtamo, J., Edwards, B. K., Rautalahti, M., Hartman, A. M., Barrett, M. J., Pietinen, P., Hartman, T. J., Sipponen, P., Lewin, K., Teerenhovi, L., Hietanen, P., Tangrea, J. A., Virtanen, M., and Heinonen, O. P. Effects of supplemental alpha-tocopherol and beta-carotene on colorectal cancer: results from a controlled trial (Finland). Cancer Causes Control 2000;11:197-205. View abstract.
  656. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat.Rev. 2007;33:407-418. View abstract.
  657. Soutar, A., Seaton, A., and Brown, K. Bronchial reactivity and dietary antioxidants. Thorax 1997;52:166-170. View abstract.
  658. Stewart, S., Prince, M., Bassendine, M., Hudson, M., James, O., Jones, D., Record, C., and Day, C. P. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J Hepatol. 2007;47:277-283. View abstract.
  659. Jarvinen, R., Knekt, P., Seppanen, R., and Teppo, L. Diet and breast cancer risk in a cohort of Finnish women. Cancer Lett. 3-19-1997;114(1-2):251-253. View abstract.
  660. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81:257-262. View abstract.
  661. Richer, S., Stiles, W., and Thomas, C. Molecular medicine in ophthalmic care. Optometry. 2009;80:695-701. View abstract.
  662. Richer, S., Devenport, J., and Lang, J. C. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. Optometry. 2007;78:213-219. View abstract.
  663. Moeller, S. M., Parekh, N., Tinker, L., Ritenbaugh, C., Blodi, B., Wallace, R. B., and Mares, J. A. Associations between intermediate age-related macular degeneration and lutein and zeaxanthin in the Carotenoids in Age-related Eye Disease Study (CAREDS): ancillary study of the Women's Health Initiative. Arch.Ophthalmol. 2006;124:1151-1162. View abstract.
  664. Flood, V., Rochtchina, E., Wang, J. J., Mitchell, P., and Smith, W. Lutein and zeaxanthin dietary intake and age related macular degeneration. Br.J.Ophthalmol. 2006;90:927-928. View abstract.
  665. Garcia, O. P., Diaz, M., Rosado, J. L., and Allen, L. H. Ascorbic acid from lime juice does not improve the iron status of iron-deficient women in rural Mexico. Am.J.Clin.Nutr. 2003;78:267-273. View abstract.
  666. Rossignol, D. A. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann.Clin Psychiatry 2009;21:213-236. View abstract.
  667. Socha, P., Horvath, A., Vajro, P., Dziechciarz, P., Dhawan, A., and Szajewska, H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. J Pediatr.Gastroenterol.Nutr. 2009;48:587-596. View abstract.
  668. Thu, B. D., Schultink, W., Dillon, D., Gross, R., Leswara, N. D., and Khoi, H. H. Effect of daily and weekly micronutrient supplementation on micronutrient deficiencies and growth in young Vietnamese children. Am J Clin Nutr 1999;69:80-86. View abstract.
  669. Fawzi, W. W., Msamanga, G. I., Spiegelman, D., Urassa, E. J., McGrath, N., Mwakagile, D., Antelman, G., Mbise, R., Herrera, G., Kapiga, S., Willett, W., and Hunter, D. J. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 5-16-1998;351:1477-1482. View abstract.
  670. Angeles-Agdeppa, I., Schultink, W., Sastroamidjojo, S., Gross, R., and Karyadi, D. Weekly micronutrient supplementation to build iron stores in female Indonesian adolescents. Am.J.Clin.Nutr. 1997;66:177-183. View abstract.
  671. Liu, D. S., Bates, C. J., Yin, T. A., Wang, X. B., and Lu, C. Q. Nutritional efficacy of a fortified weaning rusk in a rural area near Beijing. Am J Clin Nutr 1993;57:506-511. View abstract.
  672. Angeles, I. T., Schultink, W. J., Matulessi, P., Gross, R., and Sastroamidjojo, S. Decreased rate of stunting among anemic Indonesian preschool children through iron supplementation. Am J Clin Nutr 1993;58:339-342. View abstract.
  673. Suharno, D., West, C. E., Muhilal, Karyadi, D., and Hautvast, J. G. Supplementation with vitamin A and iron for nutritional anaemia in pregnant women in West Java, Indonesia. Lancet 11-27-1993;342:1325-1328. View abstract.
  674. Charoenlarp, P., Pholpothi, T., Chatpunyaporn, P., and Schelp, F. P. The effect of riboflavin on the hematologic changes in iron supplementation of schoolchildren. Southeast Asian J.Trop.Med.Public Health 1980;11:97-103. View abstract.
  675. Powers, H. J., Bates, C. J., Prentice, A. M., Lamb, W. H., Jepson, M., and Bowman, H. The relative effectiveness of iron and iron with riboflavin in correcting a microcytic anaemia in men and children in rural Gambia. Hum.Nutr.Clin.Nutr. 1983;37:413-425. View abstract.
  676. Bradfield, R. B., Jensen, M. V., Gonzales, L., and Garrayar, C. Effect of low-level iron and vitamin supplementation on a tropical anemia. Am.J.Clin.Nutr. 1968;21:57-67. View abstract.
  677. Powers, H. J., Bates, C. J., and Lamb, W. H. Haematological response to supplements of iron and riboflavin to pregnant and lactating women in rural Gambia. Hum.Nutr.Clin.Nutr. 1985;39:117-129. View abstract.
  678. Mejia, L. A. and Chew, F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. Am.J.Clin.Nutr. 1988;48:595-600. View abstract.
  679. Roberfroid, D., Huybregts, L., Lanou, H., Henry, M. C., Meda, N., Menten, J., and Kolsteren, P. Effects of maternal multiple micronutrient supplementation on fetal growth: a double-blind randomized controlled trial in rural Burkina Faso. Am J Clin Nutr 2008;88:1330-1340. View abstract.
  680. Shankar, A. H., Jahari, A. B., Sebayang, S. K., Aditiawarman, Apriatni, M., Harefa, B., Muadz, H., Soesbandoro, S. D., Tjiong, R., Fachry, A., Shankar, A. V., Atmarita, Prihatini, S., and Sofia, G. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. Lancet 1-19-2008;371:215-227. View abstract.
  681. Fawzi, W. W., Msamanga, G. I., Urassa, W., Hertzmark, E., Petraro, P., Willett, W. C., and Spiegelman, D. Vitamins and perinatal outcomes among HIV-negative women in Tanzania. N.Engl J Med 4-5-2007;356:1423-1431. View abstract.
  682. Osrin, D., Vaidya, A., Shrestha, Y., Baniya, R. B., Manandhar, D. S., Adhikari, R. K., Filteau, S., Tomkins, A., and Costello, A. M. Effects of antenatal multiple micronutrient supplementation on birthweight and gestational duration in Nepal: double-blind, randomised controlled trial. Lancet 3-12-2005;365:955-962. View abstract.
  683. Christian, P., West, K. P., Khatry, S. K., LeClerq, S. C., Pradhan, E. K., Katz, J., Shrestha, S. R., and Sommer, A. Effects of maternal micronutrient supplementation on fetal loss and infant mortality: a cluster-randomized trial in Nepal. Am J Clin Nutr 2003;78:1194-1202. View abstract.
  684. Kligler, B., Homel, P., Blank, A. E., Kenney, J., Levenson, H., and Merrell, W. Randomized trial of the effect of an integrative medicine approach to the management of asthma in adults on disease-related quality of life and pulmonary function. Altern.Ther.Health Med. 2011;17:10-15. View abstract.
  685. Levi, F., Franceschi, S., Negri, E., and La Vecchia, C. Dietary factors and the risk of endometrial cancer. Cancer 6-1-1993;71:3575-3581. View abstract.
  686. Shu, X. O., Zheng, W., Potischman, N., Brinton, L. A., Hatch, M. C., Gao, Y. T., and Fraumeni, J. F., Jr. A population-based case-control study of dietary factors and endometrial cancer in Shanghai, People's Republic of China. Am J Epidemiol. 1-15-1993;137:155-165. View abstract.
  687. Levi, F., La Vecchia, C., Gulie, C., and Negri, E. Dietary factors and breast cancer risk in Vaud, Switzerland. Nutr Cancer 1993;19:327-335. View abstract.
  688. Nahas, R. and Balla, A. Complementary and alternative medicine for prevention and treatment of the common cold. Can.Fam.Physician 2011;57:31-36. View abstract.
  689. Li, H., Li, H. Q., Wang, Y., Xu, H. X., Fan, W. T., Wang, M. L., Sun, P. H., and Xie, X. Y. An intervention study to prevent gastric cancer by micro-selenium and large dose of allitridum. Chin Med.J.(Engl.) 2004;117:1155-1160. View abstract.
  690. Mackey, A. D. and Picciano, M. F. Maternal folate status during extended lactation and the effect of supplemental folic acid. Am.J Clin.Nutr 1999;69:285-292. View abstract.
  691. Ponz de, Leon M. and Roncucci, L. Chemoprevention of colorectal tumors: role of lactulose and of other agents. Scand J Gastroenterol Suppl 1997;222:72-75. View abstract.
  692. Worthington-White, D. A., Behnke, M., and Gross, S. Premature infants require additional folate and vitamin B-12 to reduce the severity of the anemia of prematurity. Am.J Clin.Nutr 1994;60:930-935. View abstract.
  693. Czeizel, A. E., Dudas, I., and Metneki, J. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Final report. Arch Gynecol.Obstet 1994;255:131-139. View abstract.
  694. Jackson, R. T. and Latham, M. C. Anemia of pregnancy in Liberia, West Africa: a therapeutic trial. Am.J Clin.Nutr 1982;35:710-714. View abstract.
  695. Areekul, S., Subcharoen, A., Cheeramakara, C., Srisukawat, K., and Limsuwan, S. Studies on the effect of folic acid supplement on folate and vitamin B12 status in children. Southeast Asian J Trop.Med Public Health 1980;11:81-86. View abstract.
  696. Rush, D., Stein, Z., and Susser, M. A randomized controlled trial of prenatal nutritional supplementation in New York City. Pediatrics 1980;65:683-697. View abstract.
  697. Srisupandit, S., Pootrakul, P., Areekul, S., Neungton, S., Mokkaves, J., Kiriwat, O., and Kanokpongsukdi, S. A prophylactic supplementation of iron and folate in pregnancy. Southeast Asian J Trop Med Public Health 1983;14:317-323. View abstract.
  698. Fleming, A. F., Hendrickse, J. P., and Allan, N. C. The prevention of megaloblastic anaemia in pregnancy in Nigeria. J Obstet.Gynaecol.Br Commonw. 1968;75:425-432. View abstract.
  699. Osifo, B. O. The effect of folic acid and iron in the prevention of nutritional anaemias in pregnancy in Nigeria. Br J Nutr 1970;24:689-694. View abstract.
  700. Iyengar, L. and Apte, S. V. Prophylaxis of anemia in pregnancy. Am.J Clin.Nutr 1970;23:725-730. View abstract.
  701. Burland, W. L., Simpson, K., and Lord, J. Response of low birthweight infant to treatment with folic acid. Arch.Dis.Child 1971;46:189-194. View abstract.
  702. Roberts, P. M., Arrowsmith, D. E., Lloyd, A. V., and Monk-Jones, M. E. Effect of folic acid treatment on premature infants. Arch.Dis.Child 1972;47:631-634. View abstract.
  703. Stevens, D., Burman, D., Strelling, M. K., and Morris, A. Folic acid supplementation in low birth weight infants. Pediatrics 1979;64:333-335. View abstract.
  704. Kendall, A. C., Jones, E. E., Wilson, C. I., Shinton, N. K., and Elwood, P. C. Folic acid in low birthweight infants. Arch.Dis.Child 1974;49:736-738. View abstract.
  705. Basu, R. N., Sood, S. K., Ramachandran, K., Mathur, M., and Ramalingaswami, V. Etiopathogenesis of nutritional anemia in pregnancy: a therapeutic approach. Am.J Clin.Nutr 1973;26:591-594. View abstract.
  706. Fleming, A. F., Martin, J. D., Hahnel, R., and Westlake, A. J. Effects of iron and folic acid antenatal supplements on maternal haematology and fetal wellbeing. Med.J.Aust. 9-21-1974;2:429-436. View abstract.
  707. Fleming, A. F., Ghatoura, G. B., Harrison, K. A., Briggs, N. D., and Dunn, D. T. The prevention of anaemia in pregnancy in primigravidae in the guinea savanna of Nigeria. Ann Trop Med Parasitol. 1986;80:211-233. View abstract.
  708. Charoenlarp, P., Dhanamitta, S., Kaewvichit, R., Silprasert, A., Suwanaradd, C., Na-Nakorn, S., Prawatmuang, P., Vatanavicharn, S., Nutcharas, U., Pootrakul, P., and . A WHO collaborative study on iron supplementation in Burma and in Thailand. Am.J.Clin.Nutr. 1988;47:280-297. View abstract.
  709. Perez, L., Heim, L., Sherzai, A., Jaceldo-Siegl, K., and Sherzai, A. Nutrition and vascular dementia. J.Nutr.Health Aging 2012;16:319-324. View abstract.
  710. Lazzeroni, M., Gandini, S., Puntoni, M., Bonanni, B., Gennari, A., and Decensi, A. The science behind vitamins and natural compounds for breast cancer prevention. Getting the most prevention out of it. Breast 2011;20 Suppl 3:S36-S41. View abstract.
  711. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 7-20-1991;338:131-137. View abstract.
  712. Potena, L., Grigioni, F., Magnani, G., Ortolani, P., Coccolo, F., Sassi, S., Kessels, K., Marrozzini, C., Marzocchi, A., Carigi, S., Musuraca, A. C., Russo, A., Magelli, C., and Branzi, A. Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study. Am.J Transplant. 2005;5:2258-2264. View abstract.
  713. Till, U., Rohl, P., Jentsch, A., Till, H., Muller, A., Bellstedt, K., Plonne, D., Fink, H. S., Vollandt, R., Sliwka, U., Herrmann, F. H., Petermann, H., and Riezler, R. Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12. Atherosclerosis 2005;181:131-135. View abstract.
  714. Kirke, P. N., Daly, L. E., and Elwood, J. H. A randomised trial of low dose folic acid to prevent neural tube defects. The Irish Vitamin Study Group. Arch Dis.Child 1992;67:1442-1446. View abstract.
  715. Spence, J. D., Blake, C., Landry, A., and Fenster, A. Measurement of carotid plaque and effect of vitamin therapy for total homocysteine. Clin.Chem.Lab Med 2003;41:1498-1504. View abstract.
  716. Batu, A. T., Toe, T., Pe, H., and Nyunt, K. K. A prophylactic trial of iron and folic acid supplements in pregnant Burmese women. Isr.J.Med.Sci. 1976;12:1410-1417. View abstract.
  717. Marcucci, R., Zanazzi, M., Bertoni, E., Rosati, A., Fedi, S., Lenti, M., Prisco, D., Castellani, S., Abbate, R., and Salvadori, M. Vitamin supplementation reduces the progression of atherosclerosis in hyperhomocysteinemic renal-transplant recipients. Transplantation 5-15-2003;75:1551-1555. View abstract.
  718. The nutrition of expectant and nursing mothers in relation to maternal and infant mortality and morbidity. J Obstet.Gynaecol.Br Emp. 1946;53:498-509. View abstract.
  719. Iyengar, L. and Rajalakshmi, K. Effect of folic acid supplement on birth weights of infants. Am.J Obstet.Gynecol. 6-1-1975;122:332-336. View abstract.
  720. Colman, N., Larsen, J. V., Barker, M., Barker, E. A., Green, R., and Metz, J. Prevention of folate deficiency by food fortification. III. Effect in pregnant subjects of varying amounts of added folic acid. Am.J Clin.Nutr 1975;28:465-470. View abstract.
  721. Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India. Indian J Med Res 2000;112:206-211. View abstract.
  722. Sood, S. K., Ramachandran, K., Mathur, M., Gupta, K., Ramalingaswamy, V., Swarnabai, C., Ponniah, J., Mathan, V. I., and Baker, S. J. W.H.O. sponsored collaborative studies on nutritional anaemia in India. 1. The effects of supplemental oral iron administration to pregnant women. Q.J.Med. 1975;44:241-258. View abstract.
  723. Tee, E. S., Kandiah, M., Awin, N., Chong, S. M., Satgunasingam, N., Kamarudin, L., Milani, S., Dugdale, A. E., and Viteri, F. E. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls. Am.J.Clin.Nutr. 1999;69:1249-1256. View abstract.
  724. Arroll, B. Non-antibiotic treatments for upper-respiratory tract infections (common cold). Respir.Med 2005;99:1477-1484. View abstract.
  725. Yaffe, K., Clemons, T. E., McBee, W. L., and Lindblad, A. S. Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial. Neurology 11-9-2004;63:1705-1707. View abstract.
  726. Sieswerda, E., van Dalen, E. C., Postma, A., Cheuk, D. K., Caron, H. N., and Kremer, L. C. Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer. Cochrane Database Syst.Rev. 2011;:CD008011. View abstract.
  727. Witte, K. K., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H. D., Anker, S. D., Clark, A. L., and Cleland, J. G. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005;26:2238-2244. View abstract.
  728. van Dalen, E. C., Caron, H. N., Dickinson, H. O., and Kremer, L. C. Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane.Database.Syst.Rev 2005;:CD003917. View abstract.
  729. Sherman, L., Glennon, J. A., Brech, W. J., Klomberg, G. H., and Gordon, E. S. Failure of trivalent chromium to improve hyperglycemia in diabetes mellitus. Metabolism 1968;17:439-442. View abstract.
  730. Huang, J., Frohlich, J., and Ignaszewski, A. P. The impact of dietary changes and dietary supplements on lipid profile. Can J Cardiol 2011;27:488-505. View abstract.
  731. Mann, J. I., Appleby, P. N., Key, T. J., and Thorogood, M. Dietary determinants of ischaemic heart disease in health conscious individuals. Heart 1997;78:450-455. View abstract.
  732. Kato, I., Akhmedkhanov, A., Koenig, K., Toniolo, P. G., Shore, R. E., and Riboli, E. Prospective study of diet and female colorectal cancer: the New York University Women's Health Study. Nutr Cancer 1997;28:276-281. View abstract.
  733. Tzonou, A., Lipworth, L., Kalandidi, A., Trichopoulou, A., Gamatsi, I., Hsieh, C. C., Notara, V., and Trichopoulos, D. Dietary factors and the risk of endometrial cancer: a case--control study in Greece. Br.J Cancer 1996;73:1284-1290. View abstract.
  734. Negri, E., La, Vecchia C., Franceschi, S., Levi, F., and Parazzini, F. Intake of selected micronutrients and the risk of endometrial carcinoma. Cancer 3-1-1996;77:917-923. View abstract.
  735. Barbone, F., Austin, H., and Partridge, E. E. Diet and endometrial cancer: a case-control study. Am J Epidemiol. 2-15-1993;137:393-403. View abstract.
  736. Salazar-Martinez, E., Lazcano-Ponce, E., Sanchez-Zamorano, L. M., Gonzalez-Lira, G., Escudero-DE Los, Rios P., and Hernandez-Avila, M. Dietary factors and endometrial cancer risk. Results of a case-control study in Mexico. Int.J Gynecol.Cancer 2005;15:938-945. View abstract.
  737. Terry, P., Vainio, H., Wolk, A., and Weiderpass, E. Dietary factors in relation to endometrial cancer: a nationwide case-control study in Sweden. Nutr Cancer 2002;42:25-32. View abstract.
  738. Hellenbrand, W., Boeing, H., Robra, B. P., Seidler, A., Vieregge, P., Nischan, P., Joerg, J., Oertel, W. H., Schneider, E., and Ulm, G. Diet and Parkinson's disease. II: A possible role for the past intake of specific nutrients. Results from a self-administered food-frequency questionnaire in a case-control study. Neurology 1996;47:644-650. View abstract.
  739. Paganini-Hill, A. Risk factors for parkinson's disease: the leisure world cohort study. Neuroepidemiology 2001;20:118-124. View abstract.
  740. Boyle, P., Diehm, C., and Robertson, C. Meta-analysis of clinical trials of Cyclo 3 Fort in the treatment of chronic venous insufficiency. Int Angiol. 2003;22:250-262. View abstract.
  741. Matthan, N. R., Giovanni, A., Schaefer, E. J., Brown, B. G., and Lichtenstein, A. H. Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL. J Lipid Res 2003;44:800-806. View abstract.
  742. Richer, S. Multicenter ophthalmic and nutritional age-related macular degeneration study--part 2: antioxidant intervention and conclusions. J.Am.Optom.Assoc. 1996;67:30-49. View abstract.
  743. Li, J. Y., Taylor, P. R., Li, B., Dawsey, S., Wang, G. Q., Ershow, A. G., Guo, W., Liu, S. F., Yang, C. S., Shen, Q., and . Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. J.Natl.Cancer Inst. 9-15-1993;85:1492-1498. View abstract.
  744. Homnick, D. N., Spillers, C. R., Cox, S. R., Cox, J. H., Yelton, L. A., DeLoof, M. J., Oliver, L. K., and Ringer, T. V. Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis. J.Pediatr. 1995;127:491-494. View abstract.
  745. Hennekens, C. H. and Eberlein, K. A randomized trial of aspirin and beta-carotene among U.S. physicians. Prev.Med. 1985;14:165-168. View abstract.
  746. Evans, J. R. and Lawrenson, J. G. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane.Database.Syst.Rev. 2012;11:CD000254. View abstract.
  747. Cortes-Jofre, M., Rueda, J. R., Corsini-Munoz, G., Fonseca-Cortes, C., Caraballoso, M., and Bonfill, Cosp, X. Drugs for preventing lung cancer in healthy people. Cochrane.Database.Syst.Rev. 2012;10:CD002141. View abstract.
  748. Mathew, M. C., Ervin, A. M., Tao, J., and Davis, R. M. Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract. Cochrane.Database.Syst.Rev. 2012;6:CD004567. View abstract.
  749. Evans, J. R. and Lawrenson, J. G. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane.Database.Syst.Rev. 2012;6:CD000253. View abstract.
  750. Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., and Gluud, C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane.Database.Syst.Rev. 2012;3:CD007176. View abstract.
  751. Knekt, P., Aromaa, A., Maatela, J., Aaran, R. K., Nikkari, T., Hakama, M., Hakulinen, T., Peto, R., and Teppo, L. Serum vitamin A and subsequent risk of cancer: cancer incidence follow-up of the Finnish Mobile Clinic Health Examination Survey. Am.J.Epidemiol. 1990;132:857-870. View abstract.
  752. Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., and . A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group. N.Engl.J.Med. 9-20-1990;323:789-795. View abstract.
  753. Fulan, H., Changxing, J., Baina, W. Y., Wencui, Z., Chunqing, L., Fan, W., Dandan, L., Dianjun, S., Tong, W., Da, P., and Yashuang, Z. Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression. Cancer Causes Control 2011;22:1383-1396. View abstract.
  754. Myung, S. K., Ju, W., Kim, S. C., and Kim, H. Vitamin or antioxidant intake (or serum level) and risk of cervical neoplasm: a meta-analysis. BJOG. 2011;118:1285-1291. View abstract.
  755. Bjelakovic, G., Gluud, L. L., Nikolova, D., Bjelakovic, M., Nagorni, A., and Gluud, C. Antioxidant supplements for liver diseases. Cochrane.Database.Syst.Rev. 2011;:CD007749. View abstract.
  756. Stratton, J. and Godwin, M. The effect of supplemental vitamins and minerals on the development of prostate cancer: a systematic review and meta-analysis. Fam.Pract. 2011;28:243-252. View abstract.
  757. Nurmatov, U., Devereux, G., and Sheikh, A. Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis. J.Allergy Clin.Immunol. 2011;127:724-733. View abstract.
  758. Shamseer, L., Adams, D., Brown, N., Johnson, J. A., and Vohra, S. Antioxidant micronutrients for lung disease in cystic fibrosis. Cochrane.Database.Syst.Rev. 2010;:CD007020. View abstract.
  759. Tsiligianni, I. G. and van der Molen, T. A systematic review of the role of vitamin insufficiencies and supplementation in COPD. Respir.Res. 2010;11:171. View abstract.
  760. Park, Y., Spiegelman, D., Hunter, D. J., Albanes, D., Bergkvist, L., Buring, J. E., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Harnack, L., Kato, I., Krogh, V., Leitzmann, M. F., Limburg, P. J., Marshall, J. R., McCullough, M. L., Miller, A. B., Rohan, T. E., Schatzkin, A., Shore, R., Sieri, S., Stampfer, M. J., Virtamo, J., Weijenberg, M., Willett, W. C., Wolk, A., Zhang, S. M., and Smith-Warner, S. A. Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer: a pooled analysis of prospective cohort studies. Cancer Causes Control 2010;21:1745-1757. View abstract.
  761. Jiang, L., Yang, K. H., Tian, J. H., Guan, Q. L., Yao, N., Cao, N., Mi, D. H., Wu, J., Ma, B., and Yang, S. H. Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr.Cancer 2010;62:719-727. View abstract.
  762. Cooper, K., Squires, H., Carroll, C., Papaioannou, D., Booth, A., Logan, R. F., Maguire, C., Hind, D., and Tappenden, P. Chemoprevention of colorectal cancer: systematic review and economic evaluation. Health Technol.Assess. 2010;14:1-206. View abstract.
  763. Bjelakovic, G., Gluud, L. L., Nikolova, D., Bjelakovic, M., Nagorni, A., and Gluud, C. Meta-analysis: antioxidant supplements for liver diseases - the Cochrane Hepato-Biliary Group. Aliment.Pharmacol.Ther. 2010;32:356-367. View abstract.
  764. Papaioannou, D., Cooper, K. L., Carroll, C., Hind, D., Squires, H., Tappenden, P., and Logan, R. F. Antioxidants in the chemoprevention of colorectal cancer and colorectal adenomas in the general population: a systematic review and meta-analysis. Colorectal Dis. 2011;13:1085-1099. View abstract.
  765. Mente, A., de, Koning L., Shannon, H. S., and Anand, S. S. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch.Intern.Med. 4-13-2009;169:659-669. View abstract.
  766. Minder, E. I., Schneider-Yin, X., Steurer, J., and Bachmann, L. M. A systematic review of treatment options for dermal photosensitivity in erythropoietic protoporphyria. Cell Mol.Biol.(Noisy.-le-grand) 2009;55:84-97. View abstract.
  767. Bjelakovic, G., Nikolova, D., Simonetti, R. G., and Gluud, C. Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements. Aliment.Pharmacol.Ther. 9-15-2008;28:689-703. View abstract.
  768. Lin, J., Cook, N. R., Albert, C., Zaharris, E., Gaziano, J. M., Van, Denburgh M., Buring, J. E., and Manson, J. E. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J.Natl.Cancer Inst. 1-7-2009;101:14-23. View abstract.
  769. Bandera, E. V., Gifkins, D. M., Moore, D. F., McCullough, M. L., and Kushi, L. H. Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis. Cancer Causes Control 2009;20:699-711. View abstract.
  770. Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., and Gluud, C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane.Database.Syst.Rev. 2008;:CD007176. View abstract.
  771. Evans, J. Antioxidant supplements to prevent or slow down the progression of AMD: a systematic review and meta-analysis. Eye (Lond) 2008;22:751-760. View abstract.
  772. Gao, J., Gao, X., Li, W., Zhu, Y., and Thompson, P. J. Observational studies on the effect of dietary antioxidants on asthma: a meta-analysis. Respirology. 2008;13:528-536. View abstract.
  773. Ye, Z. and Song, H. Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies. Eur.J.Cardiovasc.Prev.Rehabil. 2008;15:26-34. View abstract.
  774. Chong, E. W., Wong, T. Y., Kreis, A. J., Simpson, J. A., and Guymer, R. H. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 10-13-2007;335:755. View abstract.
  775. Cook, N. R., Albert, C. M., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women's Antioxidant Cardiovascular Study. Arch.Intern.Med. 8-13-2007;167:1610-1618. View abstract.
  776. Kubo, A. and Corley, D. A. Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma. Am.J.Gastroenterol. 2007;102:2323-2330. View abstract.
  777. Plummer, M., Vivas, J., Lopez, G., Bravo, J. C., Peraza, S., Carillo, E., Cano, E., Castro, D., Andrade, O., Sanchez, V., Garcia, R., Buiatti, E., Aebischer, C., Franceschi, S., Oliver, W., and Munoz, N. Chemoprevention of precancerous gastric lesions with antioxidant vitamin supplementation: a randomized trial in a high-risk population. J.Natl.Cancer Inst. 1-17-2007;99:137-146. View abstract.
  778. Bleys, J., Miller, E. R., III, Pastor-Barriuso, R., Appel, L. J., and Guallar, E. Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials. Am.J Clin.Nutr 2006;84:880-887. View abstract.
  779. Huang, H. Y., Caballero, B., Chang, S., Alberg, A. J., Semba, R. D., Schneyer, C. R., Wilson, R. F., Cheng, T. Y., Vassy, J., Prokopowicz, G., Barnes, G. J., and Bass, E. B. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Ann.Intern.Med. 9-5-2006;145:372-385. View abstract.
  780. Coulter, I. D., Hardy, M. L., Morton, S. C., Hilton, L. G., Tu, W., Valentine, D., and Shekelle, P. G. Antioxidants vitamin C and vitamin e for the prevention and treatment of cancer. J Gen.Intern Med 2006;21:735-744. View abstract.
  781. Evans, J. R. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane.Database.Syst.Rev 2006;:CD000254. View abstract.
  782. Cho, E., Hunter, D. J., Spiegelman, D., Albanes, D., Beeson, W. L., van den Brandt, P. A., Colditz, G. A., Feskanich, D., Folsom, A. R., Fraser, G. E., Freudenheim, J. L., Giovannucci, E., Goldbohm, R. A., Graham, S., Miller, A. B., Rohan, T. E., Sellers, T. A., Virtamo, J., Willett, W. C., and Smith-Warner, S. A. Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies. Int.J.Cancer 2-15-2006;118:970-978. View abstract.
  783. Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Meyskens, F. L., Jr., Omenn, G. S., Valanis, B., and Williams, J. H., Jr. The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. J.Natl.Cancer Inst. 12-1-2004;96:1743-1750. View abstract.
  784. Chandra, R. K. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 11-7-1992;340:1124-1127. View abstract.
  785. Sasazuki, S., Sasaki, S., Tsubono, Y., Okubo, S., Hayashi, M., Kakizoe, T., and Tsugane, S. The effect of 5-year vitamin C supplementation on serum pepsinogen level and Helicobacter pylori infection. Cancer Sci. 2003;94:378-382. View abstract.
  786. Baron, J. A., Cole, B. F., Mott, L., Haile, R., Grau, M., Church, T. R., Beck, G. J., and Greenberg, E. R. Neoplastic and antineoplastic effects of beta-carotene on colorectal adenoma recurrence: results of a randomized trial. J.Natl.Cancer Inst. 5-21-2003;95:717-722. View abstract.
  787. Zhu, S., Mason, J., Shi, Y., Hu, Y., Li, R., Wahg, M., Zhou, Y., Jin, G., Xie, Y., Wu, G., Xia, D., Qian, Z., Sohg, H., Zhang, L., Russell, R., and Xiao, S. The effect of folic acid on the development of stomach and other gastrointestinal cancers. Chin Med.J.(Engl.) 2003;116:15-19. View abstract.
  788. Christen, W. G., Manson, J. E., Glynn, R. J., Gaziano, J. M., Sperduto, R. D., Buring, J. E., and Hennekens, C. H. A randomized trial of beta carotene and age-related cataract in US physicians. Arch.Ophthalmol. 2003;121:372-378. View abstract.
  789. Wood, L. G., Fitzgerald, D. A., Lee, A. K., and Garg, M. L. Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function. Am.J.Clin.Nutr. 2003;77:150-159. View abstract.
  790. Prince, M. I., Mitchison, H. C., Ashley, D., Burke, D. A., Edwards, N., Bramble, M. G., James, O. F., and Jones, D. E. Oral antioxidant supplementation for fatigue associated with primary biliary cirrhosis: results of a multicentre, randomized, placebo-controlled, cross-over trial. Aliment.Pharmacol.Ther. 2003;17:137-143. View abstract.
  791. No author. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 7-6-2002;360:23-33. View abstract.
  792. Malila, N., Virtamo, J., Virtanen, M., Pietinen, P., Albanes, D., and Teppo, L. Dietary and serum alpha-tocopherol, beta-carotene and retinol, and risk for colorectal cancer in male smokers. Eur.J.Clin.Nutr. 2002;56:615-621. View abstract.
  793. Tauler, P., Aguilo, A., Fuentespina, E., Tur, J. A., and Pons, A. Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Pflugers Arch. 2002;443(5-6):791-797. View abstract.
  794. Kockar, C., Ozturk, M., and Bavbek, N. Helicobacter pylori eradication with beta carotene, ascorbic acid and allicin. Acta Medica.(Hradec.Kralove) 2001;44:97-100. View abstract.
  795. You, W. C., Chang, Y. S., Heinrich, J., Ma, J. L., Liu, W. D., Zhang, L., Brown, L. M., Yang, C. S., Gail, M. H., Fraumeni, J. F., Jr., and Xu, G. W. An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity. Eur.J.Cancer Prev. 2001;10:257-263. View abstract.
  796. Jacobson, J. S., Begg, M. D., Wang, L. W., Wang, Q., Agarwal, M., Norkus, E., Singh, V. N., Young, T. L., Yang, D., and Santella, R. M. Effects of a 6-month vitamin intervention on DNA damage in heavy smokers. Cancer Epidemiol.Biomarkers Prev. 2000;9:1303-1311. View abstract.
  797. Renner, S., Rath, R., Rust, P., Lehr, S., Frischer, T., Elmadfa, I., and Eichler, I. Effects of beta-carotene supplementation for six months on clinical and laboratory parameters in patients with cystic fibrosis. Thorax 2001;56:48-52. View abstract.
  798. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern.Ther.Health Med. 2010;16:32-40. View abstract.
  799. Houwing, R. H., Rozendaal, M., Wouters-Wesseling, W., Beulens, J. W., Buskens, E., and Haalboom, J. R. A randomised, double-blind assessment of the effect of nutritional supplementation on the prevention of pressure ulcers in hip-fracture patients. Clin.Nutr. 2003;22:401-405. View abstract.
  800. Kahler, W., Kuklinski, B., Ruhlmann, C., and Plotz, C. [Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation]. Z Gesamte Inn.Med 1993;48:223-232. View abstract.
  801. Bartlett, H. E. and Eperjesi, F. Nutritional supplementation for type 2 diabetes: a systematic review. Ophthalmic Physiol Opt. 2008;28:503-523. View abstract.
  802. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30:628-639. View abstract.
  803. Konrad G, Katz A. Are medication restrictions before FOBT necessary?: practical advice based on a systematic review of the literature. Can Fam Physician. 2012;58:939-48. View abstract.
  804. Rabeneck L, Zwaal C, Goodman JH, et al. Cancer Care Ontario guaiac fecal occult blood test (FOBT) laboratory standards: evidentiary base and recommendations. Clin Biochem. 2008;41(16-17):1289-305. View abstract.
  805. Konturek PC, Kania J, Hahn EG, et al. Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol. 2006;57 Suppl 5:125-36. View abstract.
  806. Fidler MC, Davidsson L, Zeder C, et al. Iron absorption from ferrous fumarate in adult women is influenced by ascorbic acid but not by Na2EDTA. Br J Nutr. 2003;90:1081-5. View abstract.
  807. Jacob RA, Skala JH, Omaye ST, et al. Effect of varying ascorbic acid intakes on copper absorption and ceruloplasmin levels of young men. J Nutr. 1987;117:2109-15. View abstract.
  808. Juraschek SP, Miller ER 3rd, Gelber AC. Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trials. Arthritis Care Res (Hoboken). 2011;63:1295-306. View abstract.
  809. Huang HY, Appel LJ, Choi MJ, et al. The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial. Arthritis Rheum. 2005;52:1843-7. View abstract.
  810. de Assis SA, Vellosa JC, Brunetti IL, et al. Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil. Int J Food Sci Nutr. 2009;60:439-48. View abstract.
  811. Fairweather-Tait S, Hickson K, McGaw B, et al. Orange juice enhances aluminium absorption from antacid preparation. Eur J Clin Nutr. 1994;48:71-3. View abstract.
  812. Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database Syst Rev. 2013;8:CD005532. View abstract.
  813. Hemilä H, Koivula T. Vitamin C for preventing and treating tetanus. Cochrane Database Syst Rev. 2013;11:CD006665. View abstract.
  814. Hollinshead MB, Spillert CR, Flynn EJ, Lazaro EJ. Pharmacologic doses of ascorbic acid prolong the effects of pentobarbital anesthesia. Res Commun Chem Pathol Pharmacol. 1990;68:379-82. View abstract.
  815. Thankachan P, Walczyk T, Muthayya S, et al. Iron absorption in young Indian women: the interaction of iron status with the influence of tea and ascorbic acid. Am J Clin Nutr. 2008;87:881-6. View abstract.
  816. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009;169:384-90. View abstract.
  817. Gao X, Curhan G, Forman JP, et al. Vitamin C intake and serum uric acid concentration in men. J Rheumatol 2008;35:1853-8. View abstract.
  818. Stein HB, Hasan A, Fox IH. Ascorbic acid-induced uricosuria. A consequence of megavitamin therapy. Ann Intern Med 1976;84:385-8.. View abstract.
  819. Sutton JL, Basu TK, Dickerson JW. Effect of large doses of ascorbic acid in man on some nitrogenous components of urine. Hum Nutr Appl Nutr 1983;37:136-40. View abstract.
  820. Berger L, Gerson CD, Yu TF. The effect of ascorbic acid on uric acid excretion with a commentary on the renal handling of ascorbic acid. Am J Med 1977;62:71-6. View abstract.
  821. Mitch WE, Johnson MW, Kirschenbaum JM, Lopez RE. Effect of large doses of ascorbic acid on the uric acid excretion by normal subjects. Clin Pharmacol Ther 1981;29:318-21. View abstract.
  822. Choi HK, Goa X, Curhan G. Vitamin C intake and the risk of gout in men. Arch Intern Med 2009;169:502-7. View abstract.
  823. Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate total cancer in men: the physicians' health study II randomised controlled trial. JAMA 2009;301:52-62. View abstract.
  824. Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. View abstract.
  825. Heaney ML, Gardner JR, Karasavvas N, et al. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res 2008;68:8031-8. View abstract.
  826. Zollinger PE, Tuinebreijer WE, Breederveld RS, Kreis RW. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am 2007;89:1424-31. View abstract.
  827. Rumbold A, Duley L, Crowther C, Haslam R. Antioxidants for preventing pre-eclampsia. Cochrane Database Syst Rev 2008;:CD004227. View abstract.
  828. Baird IM, Hughes RE, Wilson HK, et al. The effects of ascorbic acid and flavonoids on the occurrence of symptoms normally associated with the common cold. Am J Clin Nutr 1979;32:1686-90. View abstract.
  829. Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007;297:842-57. View abstract.
  830. Fortner BR Jr, Danziger RE, Rabinowitz PS, Nelson HS. The effect of ascorbic acid on cutaneous and nasal response to histamine and allergen. J Allergy Clin Immunol 1982;69:484-8. View abstract.
  831. Bucca C, Rolla G, Oliva A, Farina JC. Effect of vitamin C on histamine bronchial responsiveness of patients with allergic rhinitis. Ann Allergy 1990;65:311-4. View abstract.
  832. Podoshin L, Gertner R, Fradis M. Treatment of perennial allergic rhinitis with ascorbic acid solution. Ear Nose Throat J 1991;70:54-55. View abstract.
  833. Kompauer I, Heinrich J, Wolfram G, Linseisen J. Association of carotenoids, tocopherols, and vitamin C in plasma with allergic rhinitis and allergic sensitization in adults. Public Health Nutr 2006;9:472-9. View abstract.
  834. Devereux G, Turner SW, Craig LC, et al. Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. Am J Respir Crit Care Med 2006;174:499-507. View abstract.
  835. You WC, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006;98:974-83. View abstract.
  836. Joshi K, Lad S, Kale M, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids 2006;74:17-21. View abstract.
  837. Linde K, Barrett B, Wolkart K, et al. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev 2006;:CD000530. View abstract.
  838. van Leeuwen R, Boekhoorn S, Vingerling JR, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 2005;294:3101-7. View abstract.
  839. Black PN, Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the Third National Health and Nutrition Examination Survey. Chest 2005;128:3792-8. View abstract.
  840. Meyer F, Galan P, Douville P, et al. Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial. Int J Cancer 2005;116:182-6. View abstract.
  841. Kirsh VA, Hayes RB, Mayne ST, et al. Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer risk. J Natl Cancer Inst 2006;98:245-54. View abstract.
  842. Hercberg S, Galan P, Preziosi P, et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 2004;164:2335-42. View abstract.
  843. Knekt P, Ritz J, Pereira MA, et al. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Am J Clin Nutr 2004;80:1508-20. View abstract.
  844. Dammann HG, Saleki M, Torz M, et al. Effects of battered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric mucosa in healthy subjects. Aliment Pharmacol Ther 2004;19:367-74. View abstract.
  845. Igarashi M. Augmentative effect of ascorbic acid upon induction of human ovulation in clomiphene-ineffective anovulatory women. Int J Fertil 1977;22:168-73. View abstract.
  846. Cross JM, MacAllister RJ, Woolfson RG. Vitamin C in renal failure--pro- or antioxidant? Kidney Int 2003;64:1531-2. View abstract.
  847. Wilson CW. Vitamin C and fertility. Lancet 1973;2:859-60. View abstract.
  848. Hemila H. Vitamin C and SARS coronavirus. J Antimicrob Chemother 2003;52:1049-50. View abstract.
  849. Chen WT, Yan HC, Yu FC. Vitamin C improves vascular resistance in patients with chronic renal failure. Kidney Int 2003;64:2325-6. View abstract.
  850. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. View abstract.
  851. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. View abstract.
  852. Kim MK, Sasaki S, Sasazuki S, et al. Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects. Br J Nutr 2004;91:81-90. View abstract.
  853. Block G, Jensen C, Dietrich M, et al. Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation. J Am Coll Nutr 2004;23:141-7. View abstract.
  854. Antoniades C, Tousoulis D, Tountas C, et al. Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. Diabet Med 2004;21;552-8. View abstract.
  855. Raschke T, Koop U, Dusing HJ, et al. Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy. Skin Pharmacol Physiol 2004;17:200-6. View abstract.
  856. Cho E, Seddon JM, Rosner B, et al. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol 2004;122:883-92. View abstract.
  857. Cesari M, Pahor M, Bartali B, et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr 2004;79:289-94. View abstract.
  858. Adams LA, Angulo P. Vitamins E and C for the treatment of NASH: duplication of results but lack of demonstration of efficacy. Am J Gastroenterol 2003;98:2348-50. View abstract.
  859. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. View abstract.
  860. Uusitupa MI, Kumpulainen JT, Voutilainen E, et al. Effect of inorganic chromium supplementation on glucose tolerance, insulin response, and serum lipids in noninsulin-dependent diabetics. Am J Clin Nutr 1983;38:404-10. View abstract.
  861. Paolisso G, Sgambato S, Gambardella A, et al. Daily magnesium supplements improve glucose handling in elderly subjects. Am J Clin Nutr 1992;55:1161-7. View abstract.
  862. Duffield-Lillico AJ, Dalkin BL, Reid ME, et al. Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int 2003;91:608-12. View abstract.
  863. Corrada M, Kawas C. Reduced risk of Alzheimer's disease with high folate Intake: The Baltimore Longitudinal Study of Aging. Alzheimers Dement 2005;1:11-18. View abstract.
  864. Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. View abstract.
  865. Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: The Women's Health Study: A randomized controlled trial. JAMA 2005;294:56-65. View abstract.
  866. Wluka AE, Stuckey S, Brand C, Cicuttini FM. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: A 2 year double blind randomized placebo controlled study. J Rheumatol 2002;29:2585-91. View abstract.
  867. Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005;352:2379-88. View abstract.
  868. Lonn E, Bosch J, Yusuf S, et al. HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-47. View abstract.
  869. Cook NR, Le IM, Manson JE, et al. Effects of beta-carotene supplementation on cancer incidence by baseline characteristics in the Physicians' Health Study (United States). Cancer Causes Control 2000;11:617-26. View abstract.
  870. Taylor EN, Stampfer MJ, Curhan GC. Dietary factors and the risk of incident kidney stones in men: new insights after 14 years of follow-up. J Am Soc Nephrol 2004;15:3225-32. View abstract.
  871. Stralsjo L, Alklint C, Olsson ME, Sjoholm I. Total folate content and retention in rosehips (Rosa ssp.) after drying. J Agric Food Chem 2003;51:4291-5. View abstract.
  872. Pino JA, Marbot R. Volatile flavor constituents of acerola (Malpighia emarginata DC.) fruit. J Agric Food Chem 2001;49:5880-2. View abstract.
  873. Lee DH, Folsom AR, Harnack L, et al. Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? Am J Clin Nutr 2004;80:1194-200. View abstract.
  874. Spargias K, Alexopoulos E, Kyrzopoulos S, et al. Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. Circulation 2004;110:2837-42. View abstract.
  875. Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:60520-53. View abstract.
  876. Bjelakovic G, Nikolova D, Simonetti RG, Gluud C. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004;364:1219-28. View abstract.
  877. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. View abstract.
  878. Kris-Etherton PM, Lichtenstein AH, Howard BV, et al. AHA Science Advisory: Antioxidant vitamin supplements and cardiovascular disease. Circulation 2004;110:637-41. View abstract.
  879. Henmi H, Endo T, Kitajima Y, et al. Effects of ascorbic acid supplementation on serum progesteron levels in patients with luteal phase defect. Fertil Steril 2003;80:459-61. View abstract.
  880. Kennedy DD, Tucker KL, Ladas ED, et al. Low antioxidant vitamin intakes are associated with increases in adverse effects of chemotherapy in children with acute lymphoblastic leukemia. Am J Clin Nutr 2004;79:1029-36. View abstract.
  881. Peters EM, Anderson R, Nieman DC, et al. Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. Int J Sports Med. 2001;22:537-43. View abstract.
  882. Rivers JM, Devine MM. Plasma ascorbic acid concentrations and oral contraceptives. Am J Clin Nutr 1972;25:684-9. View abstract.
  883. McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am J Clin Nutr 1973;26:191-6. View abstract.
  884. Richer S, Stiles W, Statkute L, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). Optometry 2004;75:216-30. View abstract.
  885. Sandstrom B. Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 2001;85:S181-5. View abstract.
  886. Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol 1974;28:53-6. View abstract.
  887. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol 1975;31:544-7. View abstract.
  888. Kelly G. The interaction of cigarette smoking and antioxidants. Part III: ascorbic acid. Altern Med Rev 2003;8:43-54. View abstract.
  889. Harris ED, Percival SS. A role for ascorbic acid in copper transport. Am J Clin Nutr 1991;54:1193s-7s. View abstract.
  890. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. View abstract.
  891. Weininger J, King JC. Effect of oral contraceptives on ascorbic acid status of young women consuming a constant diet. Nutr Rep Int 1977;15:255-64. View abstract.
  892. Johansson U, Akesson B. Interaction between ascorbic acid and acetylsalicylic acid and their effects on nutritional status in man. Int J Vitam Nutr Res 1985;55:197-204. View abstract.
  893. Basu TK. Vitamin C-aspirin interactions. Int J Vitam Nutr Res Suppl 1982;23:83-90. View abstract.
  894. Kaugars GE, Riley WT, Brandt RB, et al. The prevalence of oral lesions in smokeless tobacco users and an evaluation of risk factors. Cancer 1992;70:2579-85. View abstract.
  895. Giraud DW, Martin HD, Driskell JA. Plasma and dietary vitamin C and E levels of tobacco chewers, smokers, and nonusers. J Am Diet Assoc 1995;95:798-800. View abstract.
  896. Zandi PP, Anthony JC, Khachaturian AS, et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 2004;61:82-8. View abstract.
  897. Age-Related Eye Disease Study Research Group. Potential public health impact of age-related eye disease study results: AREDS report no. 11. Arch Ophthalmol 2003;121:1621-4. View abstract.
  898. Virtamo J, Pietinen P, Huttunen JK, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA 2003;290:476-85.. View abstract.
  899. Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. View abstract.
  900. Vihtamaki T, Parantainen J, Koivisto AM, et al. Oral ascorbic acid increases plasma oestradiol during postmenopausal hormone replacement therapy. Maturitas 2002;42:129-35. View abstract.
  901. Dysken MW, Cumming RJ, Channon RA, Davis JM. Drug interaction between ascorbic acid and fluphenazine. JAMA 1979;241:2008. View abstract.
  902. Slater GJ, Jenkins D. Beta-hydroxy-beta-methylbutyrate (HMB) supplementation and the promotion of muscle growth and strength. Sports Med 2000;30:105-16.. View abstract.
  903. Enstrom JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 1992;3:194-202.. View abstract.
  904. Ness AR, Powles JW, Khaw KT. Vitamin C and cardiovascular disease: a systematic review. J Cardiovasc Risk 1996;3:513-521.. View abstract.
  905. Tardif JC. Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. N Engl J Med 1997;337:365-372.. View abstract.
  906. Waters DD, Alderman EL, Hsia J, et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: A randomized controlled trial. JAMA 2002;288:2432-40.. View abstract.
  907. Chylack LT, Brown NP, Bron A, et al. The Roche European American Cataract Trial (REACT): A randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract. Ophthalmic Epidemiol 2002;9:49-80.. View abstract.
  908. Wu K, Helzlsouer KJ, Alberg AJ, et al. A prospective study of plasma ascorbic acid concentrations and breast cancer (United States). Cancer Causes Control 2000;11:279-83.. View abstract.
  909. Michels KB, Holmberg L, Bergkvist L, et al. Dietary antioxidant vitamins, retinol, and breast cancer incidence in a cohort of Swedish women. Int J Cancer 2001;91:563-7.. View abstract.
  910. Gandini S, Merzenich H, Robertson C, Boyle P. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Eur J Cancer 2000;36:636-46.. View abstract.
  911. Freudenheim JL, Marshall JR, Vena JE, et al. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J Natl Cancer Inst 1996;88:340-8.. View abstract.
  912. You WC, Zhang L, Gail MH, et al. Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors. J Natl Cancer Inst 2000;92:1607-12.. View abstract.
  913. Negri E, Franceschi S, Bosetti C, et al. Selected micronutrients and oral and pharyngeal cancer. Int J Cancer 2000;86:122-7.. View abstract.
  914. Byers T, Guerrero N. Epidemiologic evidence for vitamin C and vitamin E in cancer prevention. Am J Clin Nutr 1995;62:1385S-92S.. View abstract.
  915. Hodis HN, Mack WJ, LaBree L, et al. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis. JAMA 1995;273:1849-54.. View abstract.
  916. Ramirez J, Flowers NC. Leukocyte ascorbic acid and its relationship to coronary artery disease in man. Am J Clin Nutr 1980;33:2079-87.. View abstract.
  917. Kritchevsky SB, Shimakawa T, Tell GS, et al. Dietary antioxidants and carotid artery wall thickness. The ARIC Study. Atherosclerosis Risk in Communities Study. Circulation 1995;92:2142-50.. View abstract.
  918. Nyyssonen K, Parviainen MT, Salonen R, et al. Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland. BMJ 1997;314:634-8.. View abstract.
  919. Sahyoun NR, Jacques PF, Russell RM. Carotenoids, vitamins C and E, and mortality in an elderly population. Am J Epidemiol 1996;144:501-11.. View abstract.
  920. Sutter AI, Lemiengre M, Campbell H, Mackinnon HF. Antihistamines for the common cold. Cochrane Database Syst Rev 2003;:CD001267.. View abstract.
  921. Graat JM, Schouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA 2002;288:715-21. View abstract.
  922. Melchart D, Linde K, Fischer P, Kaesmayr J. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev 2000;2:CD000530.. View abstract.
  923. Takkouche B, Regueira-Mendez C, Garcia-Closas R, et al. Intake of vitamin C and zinc and risk of common cold: a cohort study. Epidemiology 2002;13:38-44.. View abstract.
  924. Johnston CS, Solomon RE, Corte C. Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults. J Am Coll Nutr 1996;15:586-591. View abstract.
  925. Offenbacher EG. Promotion of chromium absorption by ascorbic acid. Trace Elements Electrolytes 1994;11:178-81.
  926. Wilson CW, Greene M. The relationship of aspirin to ascorbic acid metabolism during the common cold. J Clin Pharmacol 1978;18:21-8. View abstract.
  927. Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet 1971;1:937-8. View abstract.
  928. Loh HS, Wilson CW. The interactions of aspirin and ascorbic acid in normal men. J Clin Pharmacol 1975;15:36-45.
  929. Hansten PD, Hayton WL. Effect of antacid and ascorbic acid on serum salicylate concentration. J Clin Pharmacol 1980;20:326-31. View abstract.
  930. Mc Leod DC, Nahata MC. Inefficacy of ascorbic acid as a urinary acidifier (letter). N Engl J Med 1977;296:1413. View abstract.
  931. Kuo SM, Lin CP. 17Beta-estradiol inhibition of ascorbic acid accumulation in human intestinal Caco-2 cells. Eur J Pharmacol 1998;361:253-9. View abstract.
  932. Hudiburgh NK, Milner AN. Influence of oral contraceptives on ascorbic acid and triglyceride status. J Am Diet Assoc 1979;75:19-22. View abstract.
  933. Rivers JM. Oral contraceptives and ascorbic acid. Am J Clin Nutr 1975;28:550-4. View abstract.
  934. Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature 1972;238:277.
  935. Mowat C, Carswell A, Wirz A, McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22. View abstract.
  936. Partridge NA, Regnier FE, White JL, Hem SL. Influence of dietary constituents on intestinal absorption of aluminum. Kidney Int 1989;35:1413-7. View abstract.
  937. Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. View abstract.
  938. Domingo JL, Gomez M, Llobet JM, Richart C. Effect of ascorbic acid on gastrointestinal aluminum absorption (letter). Lancet 1991;338:1467. View abstract.
  939. Thorp VJ. Effect of oral contraceptive agents on vitamin and mineral requirements. J Am Diet Assoc 1980;76:581-4.. View abstract.
  940. Salonen RM, Nyyssonen K, Kaikkonen J, et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation 2003;107:947-53.. View abstract.
  941. Hamilton IM, Gilmore WS, Benzie IF, et al. Interactions between vitamins C and E in human subjects. Br J Nutr 2000;84:261-7. View abstract.
  942. Gaede P, Poulsen HE, Parving HH, Pedersen O. Double-blind, randomised study of the effect of combined treatment with vitamin C and E on albuminuria in Type 2 diabetic patients. Diabet Med 2001;18:756-60.. View abstract.
  943. Pace A, Savarese A, Picardo M, et al. Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. J Clin Oncol 2003;21:927-31.. View abstract.
  944. Yoshinaga M, Ohtani A, Harada N, et al. Vitamin C inhibits corpus gastritis in Helicobacter pylori-infected patients during acid-suppressive therapy. J Gastroenterol Hepatol 2001;16:1206-10.. View abstract.
  945. Zullo A, Rinaldi V, Hassan C, et al. Ascorbic acid and intestinal metaplasia in the stomach: a prospective, randomized study. Aliment Pharmacol Ther 2000;14:1303-9.. View abstract.
  946. Osganian SK, Stampfer MJ, Rimm E, et al. Vitamin C and risk of coronary heart disease in women. J Am Coll Cardiol 2003;42:246-52.. View abstract.
  947. Pohle T, Brzozowski T, Becker JC, et al. Role of reactive oxygen metabolites in aspirin-induced gastric damage in humans: gastroprotection by vitamin C. Aliment Pharmacol Ther 2001;15:677-87.. View abstract.
  948. Traxer O, Huet B, Poindexter J, et al. Effect of ascorbic acid consumption on urinary stone risk factors. J Urol 2003;170:397-401.. View abstract.
  949. Nishiguchi S, Shiomi S, Enomoto M, et al. Does ascorbic acid prevent retinopathy during interferon therapy in patients with chronic hepatitis C? J Gastroenterol 2001;36:486-91.. View abstract.
  950. Block G, Mangels AR, Norkus EP, et al. Ascorbic acid status and subsequent diastolic and systolic blood pressure. Hypertension 2001;37:261-7.. View abstract.
  951. Brody S, Preut R, Schommer K, Schurmeyer TH. A randomized controlled trial of high dose ascorbic acid for reduction of blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology 2002;159:319-24.. View abstract.
  952. Engler MM, Engler MB, Malloy MJ, et al. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation 2003;108:1059-63.. View abstract.
  953. Cho E, Hung S, Willet W, et al. Prospective study of dietary fat and the risk of age-related macular degeneration. Am J Clin Nutr 2001;73:209-18.. View abstract.
  954. Mossad SB. Effect of zincum gluconicum nasal gel on the duration and symptom severity of the common cold in otherwise healthy adults. QJM 2003;96:35-43. View abstract.
  955. Luchsinger JA, Tang M, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 2003;60:203-8.. View abstract.
  956. Klipstein-Grobusch K, den Breeijen JH, Grobbee DE, et al. Dietary antioxidants and peripheral arterial disease: the Rotterdam study. Am J Epidemiol 2001;154:145-9.. View abstract.
  957. Kershner J, Hawke W. Megavitamins and learning disorders: a controlled double-blind experiment. J Nutr 1979;109:819-26.. View abstract.
  958. Arnold LE, Christopher J, Huestis RD, Smeltzer DJ. Megavitamins for minimal brain dysfunction. A placebo-controlled study. JAMA 1978;240:2642-43.. View abstract.
  959. Haslam RH, Dalby JT, Rademaker AW. Effects of megavitamin therapy on children with attention deficit disorders. Pediatrics 1984;74:103-11.. View abstract.
  960. Jacobs EJ, Henion AK, Briggs PJ, et al. Vitamin C and vitamin E supplement use and bladder cancer mortality in a large cohort of US men and women. Am J Epidemiol 2002;156:1002-10.. View abstract.
  961. Mayne ST, Risch HA, Dubrow R, et al. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 2001;10:1055-62.. View abstract.
  962. Bachleitner-Hofmann T, Gisslinger B, Grumbeck E, Gisslinger H. Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia? Br J Haematol 2001;112:783-6.. View abstract.
  963. Hemila H. Vitamin C supplementation and common cold symptoms: problems with inaccurate reviews. Nutrition 1996;12:804-9.. View abstract.
  964. Hemila H. Vitamin C supplementation and the common cold--was Linus Pauling right or wrong? Int J Vitam Nutr Res 1997;67:329-35.. View abstract.
  965. Hemila H. Vitamin C supplementation and common cold symptoms: factors affecting the magnitude of the benefit. Med Hypotheses 1999;52:171-8. View abstract.
  966. Audera C, Patulny RV, Sander BH, Douglas RM. Mega-dose vitamin C in treatment of the common cold: a randomized controlled trial. Med J Aust 2001;175:359-62.. View abstract.
  967. Carr AB, Einstein R, Lai LY, et al. Vitamin C and the common cold: using identical twins as controls. Med J Aust 1981;2:411-2.. View abstract.
  968. Hemila H. Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Int J Sports Med 1996;17:379-83.. View abstract.
  969. Batterham M, Gold J, Naidoo D, et al. A preliminary open label dose comparison using an antioxidant regimen to determine the effect on viral load and oxidative stress in men with HIV/AIDS. Eur J Clin Nutr 2001;55:107-14.. View abstract.
  970. Simon JA, Hudes ES. Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults. Am J Epidemiol 2001;154:427-33.. View abstract.
  971. Evans AT, Husain S, Durairaj L, et al. Azithromycin for acute bronchitis: a randomised, double-blind, controlled trial. Lancet 2002;359:1648-54.. View abstract.
  972. Prasad KN, Cole WC, Kumar B, Che Prasad K. Pros and cons of antioxidant use during radiation therapy. Cancer Treat Rev 2002;28:79-91.. View abstract.
  973. Kennedy M, Bruninga K, Mutlu EA, et al. Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E and C. Am J Gastroenterol 2001;96:1080-4.. View abstract.
  974. Laurin D, Foley DJ, Masaki KH, et al. Vitamin E and C supplements and risk of dementia. JAMA 2002;288:2266-8. View abstract.
  975. Flood V, Smith W, Wang JJ, et al. Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study. Ophthalmology 2002;109:2272-8.. View abstract.
  976. Mullan BA, Young IS, Fee H, McCance DR. Ascorbic acid reduces blood pressure and arterial stiffness in type 2 diabetes. Hypertension 2002;40:804-9.. View abstract.
  977. Kim MK, Sasaki S, Sasazuki S, et al. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension 2002;40:797-803.. View abstract.
  978. Natali A, Sironi AM, Toschi E, et al. Effect of vitamin C on forearm blood flow and glucose metabolism in essential hypertension. Arterioscler Thromb Vasc Biol 2000;20:2401-6.. View abstract.
  979. Hirashima O, Kawano H, Motoyama T, et al. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol 2000;35:1860-6.. View abstract.
  980. Raitakari OT, Adams MR, McCredie RJ, et al. Oral vitamin C and endothelial function in smokers: short-term improvement, but no sustained beneficial effect. J Am Coll Cardiol 2000;35:1616-21.. View abstract.
  981. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002;360:23-33.. View abstract.
  982. Rossig L, Hoffmann J, Hugel B, et al. Vitamin C inhibits endothelial cell apoptosis in congestive heart failure. Circulation 2001;104:2182-7.. View abstract.
  983. Lonn E. Do antioxidant vitamins protect against atherosclerosis? The proof is still lacking. J Am Coll Cardiol 2001;38:1795-8. View abstract.
  984. McQuillan BM, Hung J, Beilby JP, et al. Antioxidant vitamins and the risk of carotid atherosclerosis. The Perth Carotid Ultrasound Disease Assessment study (CUDAS). J Am Coll Cardiol 2001;38:1788-94.. View abstract.
  985. Langlois M, Duprez D, Delanghe J, et al. Serum vitamin C concentration is low in peripheral arterial disease and is associated with inflammation and severity of atherosclerosis. Circulation 2001;103:1863-8.. View abstract.
  986. Carr AC, Zhu BZ, Frei B. Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E). Circ Res 2000;87:349-54. View abstract.
  987. Johnston CS, Bowling DL. Stability of ascorbic acid in commercially available orange juices. J Am Diet Assoc 2002;102:525-9.. View abstract.
  988. Johnston CS, Thompson LL. Vitamin C status of an outpatient population. J Am Coll Nutr 1998;17:366-70. View abstract.
  989. Padayatty SJ, Levine M. New insights into the physiology and pharmacology of vitamin C. CMAJ 2001;164:353-5. View abstract.
  990. Kuo SM, Lin CP, Morehouse HF Jr. Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life Sci 2001;68:1751-60.. View abstract.
  991. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA 1972;221:1166. View abstract.
  992. Hume R, Johnstone JM, Weyers E. Interaction of ascorbic acid and warfarin. JAMA 1972;219:1479. View abstract.
  993. Rosenthal G. Interaction of ascorbic acid and warfarin. JAMA 1971;215:1671. View abstract.
  994. Fawzi WW, Msamanga GI, Hunter D, et al. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002;16:1935-44.. View abstract.
  995. Peretz A, Siderova V, Neve J. Selenium supplementation in rheumatoid arthritis investigated in a double blind, placebo-controlled trial. Scand J Rheumatol 2001;30:208-12.. View abstract.
  996. Duffield-Lillico AJ, Reid ME, et al. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev 2002;11:630-9.. View abstract.
  997. Lynch SR. Interaction of iron with other nutrients. Nutr Rev 1997;55:102-10.. View abstract.
  998. Hallberg L, Hulthen L. Prediction of dietary iron absorption: an algorithm for calculating absorption and bioavailability of dietary iron. Am J Clin Nutr 2000;71:1147-60.. View abstract.
  999. Cook JD, Reddy MB. Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr 2001;73:93-8.. View abstract.
  1000. Fleming DJ, Jacques PF, Dallal GE, et al. Dietary determinants of iron stores in a free-living elderly population: The Framingham Heart Study. Am J Clin Nutr 1998;67:722-33.. View abstract.
  1001. Cook JD. Food iron availability: back to the basics. Am J Clin Nutr 1998;67:593-4. View abstract.
  1002. Mydlik M, Derzsiova K, Zemberova E. Influence of water and sodium diuresis and furosemide on urinary excretion of vitamin B6, oxalic acid and vitamin C in chronic renal failure. Miner Electrolyte Metab 1999;25:352-6.. View abstract.
  1003. Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr 2000;3:125-50.. View abstract.
  1004. Herbert V, Jacob E. Destruction of vitamin B12 by ascorbic acid. JAMA 1974;230:241-2. View abstract.
  1005. Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer 2000;88:737-48.. View abstract.
  1006. Fairfield KM, Hankinson SE, Rosner BA, et al. Risk of ovarian carcinoma and consumption of vitamins A, C, and E and specific carotenoids: a prospective analysis. Cancer 2001;92:2318-26.. View abstract.
  1007. Girodon F, Lombard M, Galan P, et al. Effect of micronutrient supplementation on infection in institutionalized elderly subjects: a controlled trial. Ann Nutr Metab 1997;41:98-107. View abstract.
  1008. Belongia EA, Berg R, Liu K. A randomized trial of zinc nasal spray for the treatment of upper respiratory illness in adults. Am J Med 2001;111:103-8. View abstract.
  1009. Mullins RJ, Heddle R. Adverse reactions associated with echinacea: the Australian experience. Ann Allergy Asthma Immunol 2002;88:42-51. View abstract.
  1010. Schnyder G, Roffi M, Pin R, et al. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med 2001;345:1593-600. View abstract.
  1011. Title LM, Cummings PM, Giddens K, et al. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol 2000;36:758-65. View abstract.
  1012. Watkins ML, Erickson JD, Thun MJ, et al. Multivitamin use and mortality in a large prospective study. Am J Epidemiol 2000;152:149-62.. View abstract.
  1013. Keli SO, Hertog MG, Feskens EJ, Kromhout D. Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 1996;156:637-42. View abstract.
  1014. Knekt P, Reunanen A, Jarvinen R, et al. Antioxidant vitamin intake and coronary mortality in a longitudinal population study. Am J Epidemiol 1994;139:1180-9. View abstract.
  1015. Gey KF, Stahelin HB, Eichholzer M. Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel Prospective Study. Clin Investig 1993;71:3-6. View abstract.
  1016. Joshipura KJ, Ascherio A, Manson JE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999;282:1233-39.. View abstract.
  1017. Yochum LA, Folsom AR, Kushi LH. Intake of antioxidant vitamins and risk of death from stroke in postmenopausal women. Am J Clin Nutr 2000;72:476-83.. View abstract.
  1018. Brown BG, Zhao XQ, Chait A. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. View abstract.
  1019. Klipstein-Grobusch K, Geleijnse JM, den Breeijen JH, et al. Dietary antioxidants and risk of myocardial infarction in the elderly: the Rotterdam Study. Am J Clin Nutr 1999;69:261-6. View abstract.
  1020. Goodman MT, Wilkens LR, Hankin JH, et al. Association of soy and fiber consumption with the risk of endometrial cancer. Am J Epidemiol 1997;146:294-306. View abstract.
  1021. Lee HP, Gourley L, Duffy SW, et al. Dietary effects on breast-cancer risk in Singapore. Lancet 1991;337:1197-200. View abstract.
  1022. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol 2001;119:1439-52. View abstract.
  1023. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report no. 8. Arch Ophthalmol 2001;119:1417-36. View abstract.
  1024. Gorton HC, Jarvis K. The effectiveness of vitamin C in preventing and relieving the symptoms of virus-induced respiratory infections. J Manipulative Physiol Ther 1999;22:530-3. View abstract.
  1025. Hemila H. Vitamin C intake and susceptibility to the common cold. Br J Nutr 1997;77:59-72. View abstract.
  1026. Gorman JF. The vitamin C controversy. Postgrad Med 1980;67:64,69. View abstract.
  1027. Lee SH, Oe T, Blair IA. Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins. Science 2001;292:2083-4. View abstract.
  1028. Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Diabetes 1997;46:1786-91. View abstract.
  1029. Douglas RM, Miles HB, Moore BW, et al. Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults. Antimicrob Agents Chemother 1987;31:1263-5. View abstract.
  1030. Stur M, Tittl M, Reitner A, Meisinger V. Oral zinc and the second eye in age-related macular degeneration. Invest Ophthalmol Vis Sci 1996;37:1225-35. View abstract.
  1031. Newsome DA, Swartz M, Leone NC, et al. Oral zinc in macular degeneration. Arch Ophthalmol 1988;106:192-8. View abstract.
  1032. VandenLangenberg GM, Mares-Perlman JA, Klein R, et al. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am J Epidemiol 1998;148:204-14. View abstract.
  1033. Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized, controlled trial. MIN. VIT. AOX. geriatric network. Arch Intern Med 1999;159:748-54. View abstract.
  1034. Jackson JL, Lesho E, Peterson C. Zinc and the common cold: a meta-analysis revisited. J Nutr 2000;130:1512S-5S. View abstract.
  1035. Marshall I. Zinc for the common cold. Cochrane Database Syst Rev 2000;:CD001364. View abstract.
  1036. Hirt M, Nobel S, Barron E. Zinc nasal gel for the treatment of common cold symptoms: A double-blind, placebo-controlled trial. Ear Nose Throat J 2000;79:778-82.. View abstract.
  1037. Douglas RM, Chalker EB, Treacy B. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2000;:CD000980. View abstract.
  1038. Houston JB, Levy G. Drug biotransformation interactions in man VI: Acetaminophen and ascorbic acid. J Pharm Sci 1976;65:1218-21. View abstract.
  1039. Cellex-C product information for professionals. Cellex-C. Available at: www.cellex-c.com/pro_side/navigator.html (Accessed 14 June 2000).
  1040. Traikovich SS. Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg 1999;125:1091-8. View abstract.
  1041. Katz J, West KP Jr, Khatry SK, et al. Maternal low-dose vitamin A or {beta}-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized, cluster trial in Nepal. Am J Clin Nutr 2000;71:1570-6. View abstract.
  1042. Israel RJ, Sonis ST. Topical dehydroascorbic acid (DHA) reduces moderate to severe mucositis in the hamster acute radiation model. 36th Am Soc Clin Oncol Ann Mtg Prog Proceedings/Abstracts: Abstract 2367.
  1043. Kligman AM. Topical treatments for photoaged skin. Separating the reality from the hype. Postgrad Med 1997;102:115-26. View abstract.
  1044. Keller KL, Fenske NA. Uses of vitamins A, C, and E and related compounds in dermatology: A review. J Am Acad Dermatol 1998;39:611-25. View abstract.
  1045. Troisi RJ, Willett WC, Weiss ST, et al. A prospective study of diet and adult-onset asthma. Am J Respir Crit Care Med 1995;151:1401-8. View abstract.
  1046. Schwartz J, Weiss ST. Relationship between dietary vitamin C intake and pulmonary function in the First National Health and Nutrition Examination Survey (NHANES I). Am J Clin Nutr 1994;59:110-4. View abstract.
  1047. Forastiere F, Pistelli R, Sestini P, et al. Consumption of fresh fruit rich in vitamin C and wheezing symptoms in children. Thorax 2000;55:283-8. View abstract.
  1048. McAlindon TE, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 1996;39:648-56. View abstract.
  1049. Sherman DL, Keaney JF, Biegelsen ES, et al. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension 2000;35:936-41. View abstract.
  1050. Loria CM, Klag MJ, Caulfield LE, Whelton PK. Vitamin C status and mortality in US adults. Am J Clin Nutr 2000;72:139-45. View abstract.
  1051. Simon JA, Hudes ES. Serum ascorbic acid and gallbladder disease prevalence among US adults. Arch Intern Med 2000;160:931-6. View abstract.
  1052. Riemersma RA, Carruthers KF, Elton RA, Fox KA. Vitamin C and the risk of acute myocardial infarction. Am J Clin Nutr 2000;71:1181-6. View abstract.
  1053. Lykkesfeldt J, Christen S, Wallock LM, et al. Ascorbate is depleted by smoking and replaced by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr 2000;71:530-6. View abstract.
  1054. Mainous AG, Hueston WJ, Connor MK. Serum vitamin C levels and use of health care resources for wheezing episodes. Arch Fam Med 2000;9:241-5. View abstract.
  1055. Brand C, Snaddon J, Bailey M, Cicuttini F. Vitamin E is ineffective for symptomatic relief of knee osteoarthritis: a six month double blind, randomised, placebo controlled study. Ann Rheum Dis 2001;60:946-9. View abstract.
  1056. Heartwire. Antioxidants get a vote of confidence in cardiac transplant patients. Available at: http://www.theheart.org/viewEntityDispatcherAction.do?primaryKey=174806 (Accessed 13 December 2001).
  1057. Ohnishi ST, Ohnishi T, Ogunmola GB. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition 2000;16:330-8. View abstract.
  1058. Taylor JA, Weber W, Standish L, et al. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. JAMA 2003;290:2824-30.. View abstract.
  1059. Rimm EB, Ascherio A, Giovannucci E, et al. Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA 1996;275:447-51. View abstract.
  1060. Pietinen P, Rimm EB, Korhonen P, et al. Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. The alpha-tocopherol, beta-carotene cancer prevention study. Circulation 1996;94:2720-7. View abstract.
  1061. Sperduto RD, Hu TS, Milton RC, et al. The Linxian cataract studies. Two nutrition intervention trials. Arch Ophthalmol 1993;111:1246-53. View abstract.
  1062. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  1063. Creagan ET, Moertel CG, O'Fallon JR, et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 1979;301:687-90. View abstract.
  1064. Moertel CG, Fleming TR, Creagan ET, et al. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 1985;312:137-41. View abstract.
  1065. Agus DB, Vera JC, Golde DW. Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res 1999;59:4555-8. View abstract.
  1066. Vera JC, Rivas CI, Zhang RH, Golde DW. Colony-stimulating factors signal for increased transport of vitamin C in human host defense cells. Blood 1998;91:2536-46. View abstract.
  1067. Spielholz C, Golde DW, Houghton AN, et al. Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res 1997;57:2529-37. View abstract.
  1068. Vera JC, Rivas CI, Zhang RH, et al. Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood 1994;84:1628-34. View abstract.
  1069. Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 1993;57:650-6. View abstract.
  1070. Edmonds SE, Winyard PG, Guo R, et al. Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial. Ann Rheum Dis 1997;56:649-55. View abstract.
  1071. Gulmezoglu AM, Hofmeyr GJ, Oosthuisen MM. Antioxidants in the treatment of severe pre-eclampsia: an explanatory randomised controlled trial. Br J Obstet Gynaecol 1997;104:689-96. View abstract.
  1072. Eberlein-Konig B, Placzek M, Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). J Am Acad Dermatol 1998;38:45-8. View abstract.
  1073. Fuchs J, Kern H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med 1998;25:1006-12. View abstract.
  1074. Dreher F, Denig N, Gabard B, et al. Effect of topical antioxidants on UV-induced erythema formation when administered after exposure. Dermatol 1999;198:52-5. View abstract.
  1075. Dreher F, Gabard B, Schwindt DA, Maibach HI. Topical melatonin in combination with vitamins E and C protects skin from ultraviolet-induced erythema: a human study in vivo. Br J Dermatol 1998;139:332-9. View abstract.
  1076. de Rijk MC, Breteler MM, den Breeijen JH, et al. Dietary antioxidants and Parkinson disease. The Rotterdam Study. Arch Neurol 1997;54:762-5. View abstract.
  1077. Sisto T, Paajanen H, Metsa-Ketela T, et al. Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting. Ann Thorac Surg 1995;59:1519-23. View abstract.
  1078. Wang GQ, Dawsey SM, Li JY, et al. Effects of vitamin/mineral supplementation on the prevalence of histological dysplasia and early cancer of the esophagus and stomach: results from the General Population Trial in Linxian, China. Cancer Epidemiol Biomarkers Prev 1994;3:161-6. View abstract.
  1079. Dawsey SM, Wang GQ, Taylor PR, et al. Effects of vitamin/mineral supplementation on the prevalence of histological dysplasia and early cancer of the esophagus and stomach: results from the Dysplasia Trial in Linxian, China. Cancer Epidemiol Biomarkers Prev 1994;3:167-72. View abstract.
  1080. Teikari JM, Laatikainen L, Virtamo J, et al. Six-year supplementation with alpha-tocopherol and beta-carotene and age-related maculopathy. Acta Ophthalmol Scand 1998;76:224-9. View abstract.
  1081. Rohan TE, Howe GR, Friedenreich CM, et al. Dietary fiber, vitamins A, C, and E, and risk of breast cancer: a cohort study. Cancer Causes Control 1993;4:29-37. View abstract.
  1082. Hunter DJ, Manson JE, Colditz GA, et al. A prospective study of the intake of vitamins C, E, and A and the risk of breast cancer. N Engl J Med 1993;329:234-40. View abstract.
  1083. Zipursky A, Brown EJ, Watts J, et al. Oral vitamin E supplementation for the prevention of anemia in premature infants: a controlled trial. Pediatrics 1987;79:61-8. View abstract.
  1084. Masaki KH, Losonczy KG, Izmirlian G, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000;54:1265-72. View abstract.
  1085. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  1086. Mares-Perlman JA, Lyle BJ, Klein R, et al. Vitamin supplement use and incident cataracts in a population-based study. Arch Ophthalmol 2000;118:1556-63. View abstract.
  1087. Rautalahti MT, Virtamo JR, Taylor PR, et al. The effects of supplementation with alpha-tocopherol and beta-carotene on the incidence and mortality of carcinoma of the pancreas in a randomized, controlled trial. Cancer 1999;86:37-42. View abstract.
  1088. Heinonen OP, Albanes D, Virtamo J, et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 1998;90:440-6. View abstract.
  1089. McKeown-Eyssen G, Holloway C, Jazmaji V, et al. A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps. Cancer Res 1988;48:4701-5. View abstract.
  1090. Greenberg ER, Baron JA, Tosteson TD, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. N Engl J Med 1994;331:141-7. View abstract.
  1091. Roncucci L, Di Donato P, Carati L, et al. Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Colorectal Cancer Study Group of the Univ of Modena and the Health Care Dist 16. Dis Colon Rectum 1993;36:227-34. View abstract.
  1092. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. View abstract.
  1093. Losonczy KG, Harris TB, Havlik RJ. Vitamin E and vitamin C supplement use and risk of all-cause and coronary heart disease mortality in older persons:epidemiologic studies of the elderly. Am J Clin Nutr 1996;64:190-6. View abstract.
  1094. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6. View abstract.
  1095. Kushi LH, Folsom AR, Prineas RJ, et al. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med 1996;334:1156-62. View abstract.
  1096. Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med 1993;328:1450-6. View abstract.
  1097. Khaw KT, Bingham S, Welch A, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 2001;357:657-63. View abstract.
  1098. Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet 2001;357:89-95. View abstract.
  1099. Lonn E, Yusuf S, Dzavik V, et al. Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE). Circulation 2001;103:919-25. View abstract.
  1100. Stampfer MJ, Hennekens CH, Manson JE, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med 1993;328:1444-9. View abstract.
  1101. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. View abstract.
  1102. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14. View abstract.
  1103. Butland BK, Fehily AM, Elwood PC. Diet and lung function decline in a cohort of 2512 middle aged men. Thorax 2000;55:102-8. View abstract.
  1104. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. View abstract.
  1105. Cheng Y, Willett WC, Schwartz J, et al. Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol 1998;147:1162-74. View abstract.
  1106. Dawson EB, Evans DR, Harris WA, et al. The effect of ascorbic acid supplementation on the blood lead levels of smokers. J Am Coll Nutr 1999;18:166-70. View abstract.
  1107. Simon JA, Hudes ES. Relationship of ascorbic acid to blood lead levels. JAMA 1999;281:2289-93. View abstract.
  1108. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  1109. Levine M, Rumsey SC, Daruwala R, et al. Criteria and recommendations for vitamin C intake. JAMA 1999;281:1415-23. View abstract.
  1110. Mark SD, Wang W, Fraumeni JF Jr, et al. Do nutritional supplements lower the risk of stroke or hypertension? Epidemiology 1998;9:9-15. View abstract.
  1111. Clark LC, Combs GF Jr, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. JAMA 1996;276:1957-63. View abstract.
  1112. Blot WJ, Li JY, Taylor PR. Nutritional intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993;85:1483-92. View abstract.
  1113. Hennekens CH, Buring JE, Manson JE, et al. Lack of effect of long-term supplementation with beta-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996;334:1145-9. View abstract.
  1114. Green A, Williams G, Neale R, et al. Daily sunscreen applications and beta-carotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomized controlled trial. Lancet 1999;354:723-9. View abstract.
  1115. Albanes D, Heinonen OP, Taylor PR, et al. Alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of baseline characteristics and study compliance. J Natl Cancer Inst 1996;88:1560-70. View abstract.
  1116. Correa P, Fontham ETH, Bravo JC, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. J Natl Cancer Inst 2000;92:1881-8. View abstract.
  1117. Hornig B, Arakawa N, Kohler C, Drexler H. Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation 1998;97:363-8. View abstract.
  1118. Mak S, Newton GE. Vitamin C augments the inotropic response to dobutamine in humans with normal left ventricular function. Circulation 2001;103:826-30. View abstract.
  1119. Chen R, Tunstall-Pedoe H, Bolton-Smith C, et al. Association of dietary antioxidants and waist circumference with pulmonary function and airway obstruction. Am J Epidemiol 2001:153:157-63. View abstract.
  1120. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. View abstract.
  1121. Zollinger PE, Tuinebreijer WE, Kreis RW, Breederveld RS. Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomized trial. Lancet 1999;354:2025-8. View abstract.
  1122. Duffy SJ, Gokce N, Holbrook M, et al. Treatment of hypertension with ascorbic acid. Lancet 1999;354:2048-9. View abstract.
  1123. Hemila H. Vitamin C, the placebo effect, and the common cold: a case study of how preconceptions influence the analysis of results. J Clin Epidemiol 1996;49:1079-84. View abstract.
  1124. Hemila H, Herman ZS. Vitamin C and the common cold: a retrospective analysis of Chalmers' review. J Am Coll Nutr 1995;14:116-23. View abstract.
  1125. Hemila H. Does vitamin C alleviate the symptoms of the common cold?- a review of current evidence. Scand J Infect Dis 1994;26:1-6. View abstract.
  1126. Davies JE, Hughes RE, Jones E, et al. Metabolism of ascorbic acid (vitamin C) in subjects infected with common cold viruses. Biochem Med 1979;21:78-85. View abstract.
  1127. Coulehan JL. Ascorbic acid and the common cold: reviewing the evidence. Postgrad Med 1979;66:153-60. View abstract.
  1128. Anderson TW. Vitamin C and the common cold. J Med Soc N J 1979;76:765-6. View abstract.
  1129. Pitt HA, Costrini AM. Vitamin C prophylaxis in marine recruits. JAMA 1979;241:908-11.. View abstract.
  1130. Martin NG, Carr AB, Oakeshott JG, Clark P. Co-twin control studies: vitamin C and the common cold. Prog Clin Biol Res 1982;103:365-73. View abstract.
  1131. Vilter RW. Nutritional aspects of ascorbic acid: uses and abuses. West J Med 1980;133:485-92. View abstract.
  1132. Kasa RM. Vitamin C: from scurvy to the common cold. Am J Med Technol 1983;49:23-6. View abstract.
  1133. Leibovitz B, Siegel BV. Ascorbic acid and the immune response. Adv Exp Med Biol 1981;135:1-25. View abstract.
  1134. Daniel TA, Nawarskas JJ. Vitamin C in the prevention of nitrate tolerance. Ann Pharmacother 2000;34:1193-7. View abstract.
  1135. Slivka A, Kang JO, Cohen G. Ascorbic acid. N Engl J Med 1986;315:708-9. View abstract.
  1136. Alster TS, West TB. Effect of topical vitamin C on postoperative carbon dioxide laser resurfacing erythema. Dermatol Surg 1998;24:331-4. View abstract.
  1137. Gale CR, Martyn CN, Winter PD, Cooper C. Vitamin C and risk of death from stroke and coronary heart disease in cohort of elderly people. BMJ 1995;310:1563-6. View abstract.
  1138. Yokoyama T, Date C, Kokubo Y, et al. Serum vitamin C concentration was inversely associated with subsequent 20-year incidence of stroke in a Japanese rural community : the shibata study. Stroke 2000;31:2287-94. View abstract.
  1139. Kaufmann PA, Gnecchi-Ruscone T, di Terlizzi M, et al. Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function. Circulation 2000;102:1233-8. View abstract.
  1140. Lee NA, Reasner CA. Beneficial effect of chromium supplementation on serum triglyceride levels in NIDDM. Diabetes Care 1994;17:1449-52. View abstract.
  1141. Salonen JT, Nyyssonen K, Salonen R, et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med 2000;248:377-86. View abstract.
  1142. Ascherio A, Rimm EB, Hernan MA, et al. Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States. Ann Intern Med 1999;130:963-70. View abstract.
  1143. Lee IM, Cook NR, Manson JE, et al. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst 1999;91:2102-6. View abstract.
  1144. Zhang S, Hunter DJ, Forman MR, et al. Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. J Natl Cancer Inst 1999;91:547-56. View abstract.
  1145. Cohen HA, Neuman I, Nahum H. Blocking effect of vitamin C in exercise-induced asthma. Arch Pediatr Adolesc Med 1997;151:103-9. View abstract.
  1146. Watanabe H, Masaaki K, Ohtsuka S, et al. Randomized, double-blind, placebo-controlled study of the preventative effect of supplemental oral vitamin C on attenuation of development of nitrate tolerance. J Am Coll Cardiol 1998;31:1323-9. View abstract.
  1147. Tribble DL. AHA Science Advisory. Antioxidant consumption and risk of coronary heart disease: emphasis on vitamin C, vitamin E, and beta-carotene: A statement for healthcare professionals from the American Heart Association. Circulation 1999;99:591-5. View abstract.
  1148. Slattery ML, West DW, Robison LM. Fluid intake and bladder cancer in Utah. Int J Cancer 1988;42:17-22. View abstract.
  1149. Pannelli F, La Rosa F, Saltalamacchia G, et al. Tobacco smoking, coffee, cocoa and tea consumption in relation to mortality from urinary bladder cancer in Italy. Eur J Epidemiol 1989;5:392-7. View abstract.
  1150. Dwyer JH, Merz NB, Shirocre AM, et al. Progression of early atherosclerosis and intake of vitamin C and vitamin E from supplements and food. The Los Angeles Atherosclerosis Study. 41st Annual Conference on Cardiovascular Disease Epidemiology and Prevention - Abstract P77. Circulation 2001;103:1365d.
  1151. Lima M, Cruz T, Pousada JC, et al. The effect of magnesium supplementation in increasing doses on the control of type 2 diabetes. Diabetes Care 1998;21:682-6. View abstract.
  1152. Piacquadio D, Dobry M, Hunt S, et al. Short contact 70% glycolic acid peels as a treatment for photodamaged skin. A pilot study. Dermatol Surg 1996;22:449-52. View abstract.
  1153. Stiller MJ, Bartolone J, Stern R, et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind, vehicle-controlled clinical trial. Arch Dermatol 1996;132:631-6. View abstract.
  1154. Halperin EC, Gaspar L, George S, et al. A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis. Int J Radiat Oncol Biol Phys 1993;26:413-6. View abstract.
  1155. Finley EB, Cerklewski FL. Influence of ascorbic acid supplementation on copper status in young adult men. Am J Clin Nutr 1983;37:553-6. View abstract.
  1156. Kalayci O, Besler T, Kilinc K, et al. Serum levels of antioxidant vitamins (alpha tocopherol, beta carotene, and ascorbic acid) in children with bronchial asthma. Turk J Pediatr 2000;42:17-21. View abstract.
  1157. Powell CV, Nash AA, Powers HJ, Primhak RA. Antioxidant status in asthma. Pediatr Pulmonol 1994;18:34-8. View abstract.
  1158. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8. View abstract.
  1159. Young DS. Effects of Drugs on Clinical Laboratory Tests 4th ed. Washington: AACC Press, 1995.
  1160. Sano M, Ernesto C, Thomas R, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. View abstract.
  1161. Morris M, Beckett L, Scherr P, et al. Vitamin E and vitamin C supplement use and risk of incident Alzheimer's disease. Alzheimer Dis Assoc Disord 1998;12:121-6. View abstract.
  1162. Morris JC, Beeley L, Ballantine N. Interaction of ethinyloestradiol with ascorbic acid in man [letter]. Br Med J (Clin Res Ed) 1981;283:503. View abstract.
  1163. Back DJ, Breckenridge AM, MacIver M, et al. Interaction of ethinyloestradiol with ascorbic acid in man. Br Med J (Clin Res Ed) 1981;282:1516. View abstract.
  1164. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  1165. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  1166. Monographs on the medicinal uses of plant drugs. Exeter, UK: European Scientific Co-op Phytother, 1997.
Last reviewed - 03/17/2015