What is it?
Belladonna is a plant. The leaf and root are used to make medicine.
The name “belladonna” means “beautiful lady,” and was chosen because of a risky practice in Italy. The belladonna berry juice was used historically in Italy to enlarge the pupils of women, giving them a striking appearance. This was not a good idea, because belladonna can be poisonous.
Though widely regarded as unsafe, belladonna is used as a sedative, to stop bronchial spasms in asthma and whooping cough, and as a cold and hay fever remedy. It is also used for Parkinson's disease, colic, motion sickness, and as a painkiller.
Belladonna is used in ointments that are applied to the skin for joint pain (rheumatism), leg pain caused by a disc in the backbone pushing on the sciatic nerve (sciatica), and nerve pain (neuralgia). Belladonna is also used in plasters (medicine-filled gauze applied to the skin) for treating psychiatric disorders, a behavior disorder called hyperkinesis, excessive sweating (hyperhidrosis), and bronchial asthma.
Rectally, belladonna is used in hemorrhoid suppositories.
How effective is it?
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for BELLADONNA are as follows:
Insufficient evidence to rate effectiveness for...
- Irritable bowel syndrome (IBS). Early research suggests that taking belladonna along with the drug phenobarbital by mouth for one month does not improve symptoms of irritable bowel syndrome.
- Whooping cough.
- Hay fever.
- Parkinson's disease.
- Motion sickness.
- Arthritis-like pain.
- Nerve problems.
- Spasms and colic-like pain in the stomach and bile ducts.
- Other conditions.
More evidence is needed to rate the effectiveness of belladonna for these uses.
Belladonna has chemicals that can block functions of the body's nervous system. Some of the bodily functions regulated by the nervous system include salivation, sweating, pupil size, urination, digestive functions, and others.
Belladonna is LIKELY UNSAFE when taken by mouth. It contains chemicals that can be toxic.
Side effects can include dry mouth, enlarged pupils, blurred vision, red dry skin, fever, fast heartbeat, inability to urinate or sweat, hallucinations, spasms, mental problems, convulsions, and coma.
Special precautions & warnings:
Pregnancy and breast-feeding: Belladonna is LIKELY UNSAFE when taken by mouth during pregnancy. Belladonna contains potentially toxic chemicals and has been linked to reports of serious side effects. Belladonna is also LIKELY UNSAFE during breast-feeding. It can reduce milk production and also passes into breast milk.
Congestive heart failure (CHF): Belladonna might cause rapid heartbeat (tachycardia) and might make CHF worse.
Constipation: Belladonna might make constipation worse.
Down syndrome: People with Down syndrome might be extra-sensitive to the potentially toxic chemicals in belladonna and their harmful effects.
Esophageal reflux: Belladonna might make esophageal reflux worse.
Fever: Belladonna might increase the risk of overheating in people with fever.
Stomach ulcers: Belladonna might make stomach ulcers worse.
Gastrointestinal (GI) tract infections: Belladonna might slow emptying of the intestine, causing retention of bacteria and viruses that can cause infection.
Gastrointestinal (GI) tract blockage: Belladonna might make obstructive GI tract diseases (including atony, paralytic ileus, and stenosis) worse.
Hiatal hernia: Belladonna might make hiatal hernia worse.
High blood pressure: Taking large amounts of belladona can increase blood pressure. This might make blood pressure become too high in people with high blood pressure.
Narrow-angle glaucoma: Belladonna might make narrow-angle glaucoma worse.
Psychiatric disorders. Taking larga mounts of belladonna might worsen psychiatric disorders.
Rapid heartbeat (tachycardia): Belladonna might make rapid heartbeat worse.
Ulcerative colitis: Belladonna might promote complications of ulcerative colitis.
Difficulty urinating (urinary retention): Belladonna might make this urinary retention worse.
Be cautious with this combination.
Belladonna contains hyoscyamine (atropine). Atropine can reduce the effects of cisapride. Taking belladonna with cisapride might reduce the effects of cisapride.
Drying medications (Anticholinergic drugs)
Belladonna contains chemicals that cause a drying effect. It also affects the brain and heart. Drying medications called anticholinergic drugs can also cause these effects. Taking belladonna and drying medications together might cause side effects including dry skin, dizziness, low blood pressure, fast heart beat, and other serious side effects.
Some of these drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
The appropriate dose of belladonna depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for belladonna. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Atropa belladonna, Atropa acuminata, Baccifère, Belladona, Belladone, Belle-Dame, Belle-Galante, Bouton Noir, Cerise du Diable, Cerise Enragée, Cerise d’Espagne, Deadly Nightshade, Devil's Cherries, Devil's Herb, Divale, Dwale, Dwayberry, Grande Morelle, Great Morel, Guigne de la Côte, Herbe à la Mort, Herbe du Diable, Indian Belladonna, Morelle Furieuse, Naughty Man's Cherries, Poison Black Cherries, Suchi.
To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.methodology (http://www.nlm.nih.gov/medlineplus/druginfo/natural/methodology.html).
To see all references for the Belladonna page, please go to http://www.nlm.nih.gov/medlineplus/druginfo/natural/531.html.
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- Pan, S. Y. and Han, Y. F. Comparison of the inhibitory efficacy of four belladonna drugs on gastrointestinal movement and cognitive function in food-deprived mice. Pharmacology 2004;72:177-183. View abstract.
- Southgate, H. J., Egerton, M., and Dauncey, E. A. Lessons to be learned: a case study approach. Unseasonal severe poisoning of two adults by deadly nightside (Atropa belladonna). Journal of the Royal Society of Health 2000;120:127-130. View abstract.
- Corazziari, E., Bontempo, I., and Anzini, F. Effects of cisapride on distal esophageal motility in humans. Dig Dis Sci 1989;34:1600-1605. View abstract.
- Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. [Serious plant poisonings in Switzerland 1966-1994. Case analysis from the Swiss Toxicology Information Center]. Schweiz Med Wochenschr 1996;126:1085-98. View abstract.
- McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
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Last reviewed - 11/12/2014
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